CLEC11A cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	CLEC11A
Entrez Gene ID	6320
Full Name	C-type lectin domain containing 11A
Synonyms	CLECSF3,LSLCL,P47,SCGF
General protein information	Preferred Names C-type lectin domain containing 11A Names C-type lectin domain family 11 member A C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 3 C-type lectin superfamily member 3 lymphocyte secreted C-type lectin lymphocyte secreted long form of C-type lectin osteolectin stem cell growth factor stem cell growth factor; lymphocyte secreted C-type lectin
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 19 Map Location: 19q13.33
Summary	This gene encodes a member of the C-type lectin superfamily. The encoded protein is a secreted sulfated glycoprotein and functions as a growth factor for primitive hematopoietic progenitor cells. An alternative splice variant has been described but its biological nature has not been determined. [provided by RefSeq, Jul 2008].
Disorder MIM:	604713

mRNA and Protein(s)

mRNA	Protein	Name
NM_002975.2	NP_002966.1	C-type lectin domain family 11 member A precursor
NM_002975.3	NP_002966.1	C-type lectin domain family 11 member A precursor

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	CLEC11A	XP_001173878.1
	CLEC11A	XP_001116136.1
Canis lupus familiaris (dog)	CLEC11A	XP_854623.2
Homo sapiens (human)	CLEC11A	NP_002966.1
Bos taurus (cattle)	CLEC11A	NP_001091523.1
Mus musculus (house mouse)	Clec11a	NP_033157.1
Rattus norvegicus (Norway rat)	Clec11a	NP_001012477.1

Gene Ontology
Bibliography

Related articles in PubMed

Clec11a/osteolectin is an osteogenic growth factor that promotes the maintenance of the adult skeleton.
Yue R, Shen B, Morrison SJ
eLife5(2016 12)

Exploratory study for identifying systemic biomarkers that correlate with pain response in patients with intervertebral disc disorders.
Weber KT, Satoh S, Alipui DO, Virojanapa J, Levine M, Sison C, Quraishi S, Bloom O, Chahine NO
Immunologic research63(1-3)170-80(2015 Dec)

Elevated levels of endothelial-derived microparticles, and serum CXCL9 and SCGF-? are associated with unstable asymptomatic carotid plaques.
Schiro A, Wilkinson FL, Weston R, Smyth JV, Serracino-Inglott F, Alexander MY
Scientific reports516658(2015 Nov)

Prognostic value of circulating levels of stem cell growth factor beta (SCGF beta) in patients with Chagas' disease and idiopathic dilated cardiomyopathy.
Wang Y, Khan A, Heringer-Walther S, Schultheiss HP, Moreira Mda C, Walther T
Cytokine61(3)728-31(2013 Mar)

Proteomic detection of a large amount of SCGF? in the stroma of GISTs after imatinib therapy.
Da Riva L, Bozzi F, Mondellini P, Miccich? F, Fumagalli E, Vaghi E, Tarantino E, Huber V, Gronchi A, Tamborini E, Pierotti MA, Pilotti S, Bongarzone I
Journal of translational medicine9158(2011 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Clec11a maintains the adult skeleton by promoting the differentiation of mesenchymal progenitors into mature osteoblasts.
Title: Clec11a/osteolectin is an osteogenic growth factor that promotes the maintenance of the adult skeleton.

level of expression correlates with pain response in subjects with intervertebral disc disorders
Title: Exploratory study for identifying systemic biomarkers that correlate with pain response in patients with intervertebral disc disorders.

Data show that asymptomatic patients with unstable plaques exhibited higher levels of endothelial microparticles (EMPs), CXCL9 chemokine and stem cell growth factor; lymphocyte secreted C-type lectin (SCGF-beta) compared to those with stable plaques.
Title: Elevated levels of endothelial-derived microparticles, and serum CXCL9 and SCGF-? are associated with unstable asymptomatic carotid plaques.

This is the first report of SCGF beta in heart failure patients.
Title: Prognostic value of circulating levels of stem cell growth factor beta (SCGF beta) in patients with Chagas' disease and idiopathic dilated cardiomyopathy.

These studies highlight a possible role of SCGFalpha in imatinib-induced changes of gastrointestinal stromal tumors structure, consistent with a therapeutic response.
Title: Proteomic detection of a large amount of SCGF? in the stroma of GISTs after imatinib therapy.

The following CLEC11A gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CLEC11A cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu03185	NM_002975.3 Latest version!	Homo sapiens C-type lectin domain containing 11A (CLEC11A), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$154.50-$216.30 $309.00
View Old Accession Versions >>
OHu03185	NM_002975.2	Homo sapiens C-type lectin domain containing 11A (CLEC11A), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$154.50-$216.30 $309.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CLEC11A ( NM_002975.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_002966.1 Homo sapiens C-type lectin domain containing 11A (CLEC11A), mRNA.

Price & Availability↑

CloneID	OHu03185
Clone ID Related Accession (Same CDS sequence)	NM_002975.2 , NM_002975.3
Accession Version	NM_002975.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 972bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-11-29
Organism	Homo sapiens(human)
Product	C-type lectin domain family 11 member A precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF020044.1, BQ014793.1 and BU615665.1. On Oct 9, 2003 this sequence version replaced NM_002975.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF020044.1, BC005810.2 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCAGGCAG CCTGGCTTTT GGGGGCTTTG GTGGTCCCCC AGCTCTTGGG CTTTGGCCAT 
GGGGCTCGGG GAGCAGAGAG GGAGTGGGAG GGAGGCTGGG GAGGTGCCCA GGAGGAGGAG 
CGGGAGAGGG AGGCCCTGAT GCTGAAGCAT CTGCAGGAAG CCCTAGGACT GCCTGCTGGG 
AGGGGGGATG AGAATCCTGC CGGAACTGTT GAGGGAAAAG AGGACTGGGA GATGGAGGAG 
GACCAGGGGG AGGAAGAGGA GGAGGAAGCA ACGCCAACCC CATCCTCCGG CCCCAGCCCC 
TCTCCCACCC CTGAGGACAT CGTCACTTAC ATCCTGGGCC GCCTGGCCGG CCTGGACGCA 
GGCCTGCACC AGCTGCACGT CCGTCTGCAC GCGTTGGACA CCCGCGTGGT CGAGCTGACC 
CAGGGGCTGC GGCAGCTGCG GAACGCGGCA GGCGACACCC GCGATGCCGT GCAAGCCCTG 
CAGGAGGCGC AGGGTCGCGC CGAGCGCGAG CACGGCCGCT TGGAGGGCTG CCTGAAGGGG 
CTGCGCCTGG GCCACAAGTG CTTCCTGCTC TCGCGCGACT TCGAAGCTCA GGCGGCGGCG 
CAGGCGCGGT GCACGGCGCG GGGCGGGAGC CTGGCGCAGC CGGCAGACCG CCAGCAGATG 
GAGGCGCTCA CTCGGTACCT GCGCGCGGCG CTCGCTCCCT ACAACTGGCC CGTGTGGCTG 
GGCGTGCACG ATCGGCGCGC CGAGGGCCTC TACCTCTTCG AAAACGGCCA GCGCGTGTCC 
TTCTTCGCCT GGCATCGCTC ACCCCGCCCC GAGCTCGGCG CCCAGCCCAG CGCCTCGCCG 
CATCCGCTCA GCCCGGACCA GCCCAACGGT GGCACGCTCG AGAACTGCGT GGCGCAGGCC 
TCTGACGACG GCTCCTGGTG GGACCACGAC TGCCAGCGGC GTCTCTACTA CGTCTGCGAG 
TTCCCCTTCT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002966.1
CDS	179..1150
Translation	MQAAWLLGALVVPQLLGFGHGARGAEREWEGGWGGAQEEEREREALMLKHLQEALGLPAGRGDENPAGTVEGKEDWEMEEDQGEEEEEEATPTPSSGPSPSPTPEDIVTYILGRLAGLDAGLHQLHVRLHALDTRVVELTQGLRQLRNAAGDTRDAVQALQEAQGRAEREHGRLEGCLKGLRLGHKCFLLSRDFEAQAAAQARCTARGGSLAQPADRQQMEALTRYLRAALAPYNWPVWLGVHDRRAEGLYLFENGQRVSFFAWHRSPRPELGAQPSASPHPLSPDQPNGGTLENCVAQASDDGSWWDHDCQRRLYYVCEFPF

Target ORF information:

RefSeq Version	NM_002975.2
Organism	Homo sapiens(human)
Definition	Homo sapiens C-type lectin domain containing 11A (CLEC11A), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002975.2

ORF Insert Sequence:

ATGCAGGCAG CCTGGCTTTT GGGGGCTTTG GTGGTCCCCC AGCTCTTGGG CTTTGGCCAT 
GGGGCTCGGG GAGCAGAGAG GGAGTGGGAG GGAGGCTGGG GAGGTGCCCA GGAGGAGGAG 
CGGGAGAGGG AGGCCCTGAT GCTGAAGCAT CTGCAGGAAG CCCTAGGACT GCCTGCTGGG 
AGGGGGGATG AGAATCCTGC CGGAACTGTT GAGGGAAAAG AGGACTGGGA GATGGAGGAG 
GACCAGGGGG AGGAAGAGGA GGAGGAAGCA ACGCCAACCC CATCCTCCGG CCCCAGCCCC 
TCTCCCACCC CTGAGGACAT CGTCACTTAC ATCCTGGGCC GCCTGGCCGG CCTGGACGCA 
GGCCTGCACC AGCTGCACGT CCGTCTGCAC GCGTTGGACA CCCGCGTGGT CGAGCTGACC 
CAGGGGCTGC GGCAGCTGCG GAACGCGGCA GGCGACACCC GCGATGCCGT GCAAGCCCTG 
CAGGAGGCGC AGGGTCGCGC CGAGCGCGAG CACGGCCGCT TGGAGGGCTG CCTGAAGGGG 
CTGCGCCTGG GCCACAAGTG CTTCCTGCTC TCGCGCGACT TCGAAGCTCA GGCGGCGGCG 
CAGGCGCGGT GCACGGCGCG GGGCGGGAGC CTGGCGCAGC CGGCAGACCG CCAGCAGATG 
GAGGCGCTCA CTCGGTACCT GCGCGCGGCG CTCGCTCCCT ACAACTGGCC CGTGTGGCTG 
GGCGTGCACG ATCGGCGCGC CGAGGGCCTC TACCTCTTCG AAAACGGCCA GCGCGTGTCC 
TTCTTCGCCT GGCATCGCTC ACCCCGCCCC GAGCTCGGCG CCCAGCCCAG CGCCTCGCCG 
CATCCGCTCA GCCCGGACCA GCCCAACGGT GGCACGCTCG AGAACTGCGT GGCGCAGGCC 
TCTGACGACG GCTCCTGGTG GGACCACGAC TGCCAGCGGC GTCTCTACTA CGTCTGCGAG 
TTCCCCTTCT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CLEC11A ( NM_002975.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_002966.1 Homo sapiens C-type lectin domain containing 11A (CLEC11A), mRNA.

Price & Availability↑

CloneID	OHu03185
Clone ID Related Accession (Same CDS sequence)	NM_002975.2 , NM_002975.3
Accession Version	NM_002975.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 972bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-29
Organism	Homo sapiens(human)
Product	C-type lectin domain family 11 member A precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF020044.1 and BQ014793.1. On Nov 22, 2018 this sequence version replaced NM_002975.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF020044.1, SRR3476690.182083.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000250340.9/ ENSP00000250340.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGCAGGCAG CCTGGCTTTT GGGGGCTTTG GTGGTCCCCC AGCTCTTGGG CTTTGGCCAT 
GGGGCTCGGG GAGCAGAGAG GGAGTGGGAG GGAGGCTGGG GAGGTGCCCA GGAGGAGGAG 
CGGGAGAGGG AGGCCCTGAT GCTGAAGCAT CTGCAGGAAG CCCTAGGACT GCCTGCTGGG 
AGGGGGGATG AGAATCCTGC CGGAACTGTT GAGGGAAAAG AGGACTGGGA GATGGAGGAG 
GACCAGGGGG AGGAAGAGGA GGAGGAAGCA ACGCCAACCC CATCCTCCGG CCCCAGCCCC 
TCTCCCACCC CTGAGGACAT CGTCACTTAC ATCCTGGGCC GCCTGGCCGG CCTGGACGCA 
GGCCTGCACC AGCTGCACGT CCGTCTGCAC GCGTTGGACA CCCGCGTGGT CGAGCTGACC 
CAGGGGCTGC GGCAGCTGCG GAACGCGGCA GGCGACACCC GCGATGCCGT GCAAGCCCTG 
CAGGAGGCGC AGGGTCGCGC CGAGCGCGAG CACGGCCGCT TGGAGGGCTG CCTGAAGGGG 
CTGCGCCTGG GCCACAAGTG CTTCCTGCTC TCGCGCGACT TCGAAGCTCA GGCGGCGGCG 
CAGGCGCGGT GCACGGCGCG GGGCGGGAGC CTGGCGCAGC CGGCAGACCG CCAGCAGATG 
GAGGCGCTCA CTCGGTACCT GCGCGCGGCG CTCGCTCCCT ACAACTGGCC CGTGTGGCTG 
GGCGTGCACG ATCGGCGCGC CGAGGGCCTC TACCTCTTCG AAAACGGCCA GCGCGTGTCC 
TTCTTCGCCT GGCATCGCTC ACCCCGCCCC GAGCTCGGCG CCCAGCCCAG CGCCTCGCCG 
CATCCGCTCA GCCCGGACCA GCCCAACGGT GGCACGCTCG AGAACTGCGT GGCGCAGGCC 
TCTGACGACG GCTCCTGGTG GGACCACGAC TGCCAGCGGC GTCTCTACTA CGTCTGCGAG 
TTCCCCTTCT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002966.1
CDS	163..1134
Translation	MQAAWLLGALVVPQLLGFGHGARGAEREWEGGWGGAQEEEREREALMLKHLQEALGLPAGRGDENPAGTVEGKEDWEMEEDQGEEEEEEATPTPSSGPSPSPTPEDIVTYILGRLAGLDAGLHQLHVRLHALDTRVVELTQGLRQLRNAAGDTRDAVQALQEAQGRAEREHGRLEGCLKGLRLGHKCFLLSRDFEAQAAAQARCTARGGSLAQPADRQQMEALTRYLRAALAPYNWPVWLGVHDRRAEGLYLFENGQRVSFFAWHRSPRPELGAQPSASPHPLSPDQPNGGTLENCVAQASDDGSWWDHDCQRRLYYVCEFPF

Target ORF information:

RefSeq Version	NM_002975.3
Organism	Homo sapiens(human)
Definition	Homo sapiens C-type lectin domain containing 11A (CLEC11A), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002975.3

ORF Insert Sequence:

ATGCAGGCAG CCTGGCTTTT GGGGGCTTTG GTGGTCCCCC AGCTCTTGGG CTTTGGCCAT 
GGGGCTCGGG GAGCAGAGAG GGAGTGGGAG GGAGGCTGGG GAGGTGCCCA GGAGGAGGAG 
CGGGAGAGGG AGGCCCTGAT GCTGAAGCAT CTGCAGGAAG CCCTAGGACT GCCTGCTGGG 
AGGGGGGATG AGAATCCTGC CGGAACTGTT GAGGGAAAAG AGGACTGGGA GATGGAGGAG 
GACCAGGGGG AGGAAGAGGA GGAGGAAGCA ACGCCAACCC CATCCTCCGG CCCCAGCCCC 
TCTCCCACCC CTGAGGACAT CGTCACTTAC ATCCTGGGCC GCCTGGCCGG CCTGGACGCA 
GGCCTGCACC AGCTGCACGT CCGTCTGCAC GCGTTGGACA CCCGCGTGGT CGAGCTGACC 
CAGGGGCTGC GGCAGCTGCG GAACGCGGCA GGCGACACCC GCGATGCCGT GCAAGCCCTG 
CAGGAGGCGC AGGGTCGCGC CGAGCGCGAG CACGGCCGCT TGGAGGGCTG CCTGAAGGGG 
CTGCGCCTGG GCCACAAGTG CTTCCTGCTC TCGCGCGACT TCGAAGCTCA GGCGGCGGCG 
CAGGCGCGGT GCACGGCGCG GGGCGGGAGC CTGGCGCAGC CGGCAGACCG CCAGCAGATG 
GAGGCGCTCA CTCGGTACCT GCGCGCGGCG CTCGCTCCCT ACAACTGGCC CGTGTGGCTG 
GGCGTGCACG ATCGGCGCGC CGAGGGCCTC TACCTCTTCG AAAACGGCCA GCGCGTGTCC 
TTCTTCGCCT GGCATCGCTC ACCCCGCCCC GAGCTCGGCG CCCAGCCCAG CGCCTCGCCG 
CATCCGCTCA GCCCGGACCA GCCCAACGGT GGCACGCTCG AGAACTGCGT GGCGCAGGCC 
TCTGACGACG GCTCCTGGTG GGACCACGAC TGCCAGCGGC GTCTCTACTA CGTCTGCGAG 
TTCCCCTTCT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Clec11a/osteolectin is an osteogenic growth factor that promotes the maintenance of the adult skeleton.
eLife5(2016 12)
Yue R,Shen B,Morrison SJ

Exploratory study for identifying systemic biomarkers that correlate with pain response in patients with intervertebral disc disorders.
Immunologic research63(1-3)170-80(2015 Dec)
Weber KT,Satoh S,Alipui DO,Virojanapa J,Levine M,Sison C,Quraishi S,Bloom O,Chahine NO

Elevated levels of endothelial-derived microparticles, and serum CXCL9 and SCGF-? are associated with unstable asymptomatic carotid plaques.
Scientific reports516658(2015 Nov)
Schiro A,Wilkinson FL,Weston R,Smyth JV,Serracino-Inglott F,Alexander MY

Prognostic value of circulating levels of stem cell growth factor beta (SCGF beta) in patients with Chagas' disease and idiopathic dilated cardiomyopathy.
Cytokine61(3)728-31(2013 Mar)
Wang Y,Khan A,Heringer-Walther S,Schultheiss HP,Moreira Mda C,Walther T

Proteomic detection of a large amount of SCGF? in the stroma of GISTs after imatinib therapy.
Journal of translational medicine9158(2011 Sep)
Da Riva L,Bozzi F,Mondellini P,Miccich? F,Fumagalli E,Vaghi E,Tarantino E,Huber V,Gronchi A,Tamborini E,Pierotti MA,Pilotti S,Bongarzone I

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CLEC11A cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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