RTN2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	RTN2
Entrez Gene ID	6253
Full Name	reticulon 2
Synonyms	NSP2,NSPL1,NSPLI,SPG12
General protein information	Preferred Names reticulon 2 Names reticulon-2 NSP-like protein 1 NSP-like protein I neuroendocrine-specific protein-like I
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 19 Map Location: 19q13.32
Summary	This gene belongs to the family of reticulon encoding genes. Reticulons are necessary for proper generation of tubular endoplasmic reticulum and likely play a role in intracellular vesicular transport. Alternatively spliced transcript variants encoding different isoforms have been identified. Mutations at this locus have been associated with autosomal dominant spastic paraplegia-12. [provided by RefSeq, Apr 2012].
Disorder MIM:	603183
Disorder Html:	Spastic paraplegia 12, autosomal dominant, 604805 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_005619.4	NP_005610.1	reticulon-2 isoform A
NM_005619.5	NP_005610.1	reticulon-2 isoform A
NM_206900.2	NP_996783.1	reticulon-2 isoform B
NM_206901.3	NP_996784.1	reticulon-2 isoform C
NM_206901.2	NP_996784.1	reticulon-2 isoform C
NM_206900.3	NP_996783.1	reticulon-2 isoform B

Pathways from BioSystems

Homologies

Homo sapiens (human)	RTN2	NP_005610.1
Canis lupus familiaris (dog)	RTN2	XP_852420.4
Mus musculus (house mouse)	Rtn2	NP_038676.1
Rattus norvegicus (Norway rat)	Rtn2	NP_963856.1
Bos taurus (cattle)	RTN2	NP_001106731.1
Xenopus tropicalis (tropical clawed frog)	rtn2	NP_001107739.1

Gene Ontology
Bibliography

Related articles in PubMed

Identification and characterization of TMEM33 as a reticulon-binding protein.
Urade T, Yamamoto Y, Zhang X, Ku Y, Sakisaka T
The Kobe journal of medical sciences60(3)E57-65(2014 Nov)

Mutations in the ER-shaping protein reticulon 2 cause the axon-degenerative disorder hereditary spastic paraplegia type 12.
Montenegro G, Rebelo AP, Connell J, Allison R, Babalini C, D'Aloia M, Montieri P, Sch?le R, Ishiura H, Price J, Strickland A, Gonzalez MA, Baumbach-Reardon L, Deconinck T, Huang J, Bernardi G, Vance JM, Rogers MT, Tsuji S, De Jonghe P, Pericak-Vance MA, Sch?ls L, Orlacchio A, Reid E, Z?chner S
The Journal of clinical investigation122(2)538-44(2012 Feb)

Functional role of neuroendocrine-specific protein-like 1 in membrane translocation of GLUT4.
Ikemoto T, Hosoya T, Takata K, Aoyama H, Hiramatsu T, Onoe H, Suzuki M, Endo M
Diabetes58(12)2802-12(2009 Dec)

Reticulon RTN2B regulates trafficking and function of neuronal glutamate transporter EAAC1.
Liu Y, Vidensky S, Ruggiero AM, Maier S, Sitte HH, Rothstein JD
The Journal of biological chemistry283(10)6561-71(2008 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Results implicate reticulon 2 in axonopathy, show that this protein participates in a network of interactions among hereditary spastic paraplegia proteins involved in endoplasmic reticulum shaping.
Title: Mutations in the ER-shaping protein reticulon 2 cause the axon-degenerative disorder hereditary spastic paraplegia type 12.

sk-NSPl1 is a novel dantrolene receptor that plays an important role in membrane translocation of GLUT4 induced by contraction/exercise. The 23-kDa sk-NSPl1 may also be involved in the regulation of glucose levels in the whole body.
Title: Functional role of neuroendocrine-specific protein-like 1 in membrane translocation of GLUT4.

RTN2B functions as a positive regulator in the delivery of EAAC1 from the ER to the cell surface.
Title: Reticulon RTN2B regulates trafficking and function of neuronal glutamate transporter EAAC1.

Discusses cloning of mouse neuroendocrine-specific protein-like 1, in addition to partial cloning of the human ortholog. Also studies expression of both the mouse and human genes.
Title: Molecular cloning of a novel mouse gene with predominant muscle and neural expression.

The following RTN2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the RTN2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu03055	NM_206900.3 Latest version!	Homo sapiens reticulon 2 (RTN2), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$279.30 $399.00
OHu03056	NM_206901.3 Latest version!	Homo sapiens reticulon 2 (RTN2), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00
OHu20336	NM_005619.5 Latest version!	Homo sapiens reticulon 2 (RTN2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$265.30 $379.00
View Old Accession Versions >>
OHu20336	NM_005619.4	Homo sapiens reticulon 2 (RTN2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$265.30 $379.00
OHu03056	NM_206901.2	Homo sapiens reticulon 2 (RTN2), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00
OHu03055	NM_206900.2	Homo sapiens reticulon 2 (RTN2), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$279.30 $399.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

RTN2 ( NM_206900.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_996783.1 Homo sapiens reticulon 2 (RTN2), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu03055
Clone ID Related Accession (Same CDS sequence)	NM_206900.2 , NM_206900.3
Accession Version	NM_206900.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1419bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-22
Organism	Homo sapiens(human)
Product	reticulon-2 isoform B
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BK001688.1, BC073874.1, AK291967.1 and AI971392.1. On Apr 10, 2012 this sequence version replaced NM_206900.1. Transcript Variant: This variant (2) lacks an in-frame segment of the coding region, compared to variant 1. It encodes a shorter isoform (B), that is missing an internal segment compared to isoform A. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BK001688.1, AK291967.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGGCAGG TCCTGCCGGT CTTCGCCCAC TGCAAAGAAG CTCCGTCTAC AGCCTCCTCA 
ACTCCTGATT CCACAGAAGG AGGGAACGAC GACTCTGATT TTCGAGAGCT GCACACAGCC 
CGGGAATTCT CAGAGGAGGA CGAGGAGGAG ACCACGTCGC AGGACTGGGG CACCCCCCGG 
GAGCTGACCT TCTCCTACAT CGCCTTTGAT GGTGTAGTGG GCTCCGGGGG CCGCAGGGAT 
TCAACTGCCC GCCGCCCCCG CCCCCAGGGC CGCTCAGTCT CGGAACCACG AGACCAGCAC 
CCTCAGCCCA GCCTGGGCGA CAGCTTGGAG AGCATCCCCA GCCTGAGCCA ATCCCCGGAG 
CCTGGACGAC GGGGTGATCC TGACACCGCG CCTCCATCCG AGCGCCCTCT GGAAGACCTG 
AGGCTTCGGT TGGACCATCT GGGCTGGGTG GCCCGGGGAA CGGGATCCGG GGAGGACTCT 
TCCACCAGCA GCTCCACCCC GCTGGAAGAC GAAGAACCCC AAGAACCCAA CAGATTGGAG 
ACAGGAGAAG CTGGGGAAGA ACTGGACCTA CGACTCCGAC TTGCTCAGCC CTCATCGCCC 
GAGGTCTTGA CTCCCCAGCT CAGTCCGGGC TCTGGGACAC CCCAGGCCGG TACTCCGTCC 
CCATCCCGAT CGCGAGATTC GAACTCTGGG CCCGAAGAGC CATTGCTGGA AGAGGAAGAA 
AAGCAGTGGG GGCCACTGGA GCGAGAGCCA GTAAGGGGAC AGTGCCTCGA TAGCACGGAC 
CAATTAGAAT TCACGGTGGA GCCACGCCTT CTAGTGGCGG ACCTGCTGTA CTGGAAGGAC 
ACGAGGACGT CAGGAGTGGT CTTCACAGGC CTGATGGTCT CCCTCCTCTG CCTCCTGCAC 
TTTAGCATCG TGTCCGTGGC CGCGCACTTG GCTCTGTTGC TGCTCTGCGG CACCATCTCT 
CTCAGGGTTT ACCGCAAAGT GCTGCAGGCC GTGCACCGGG GGGATGGAGC CAACCCTTTC 
CAGGCCTACC TGGATGTGGA CCTCACCCTG ACTCGGGAGC AGACGGAACG TTTGTCCCAC 
CAGATCACCT CCCGCGTGGT CTCGGCGGCC ACGCAGCTGC GGCACTTCTT CCTGGTAGAA 
GACCTCGTGG ATTCCCTCAA GCTGGCCCTC CTCTTCTACA TCTTGACCTT CGTGGGTGCC 
ATCTTCAATG GTTTGACTCT TCTCATTCTG GGAGTGATTG GTCTATTCAC CATCCCCCTG 
CTGTACCGGC AGCACCAGGC TCAGATCGAC CAATATGTGG GGTTGGTGAC CAATCAGTTG 
AGCCACATCA AAGCTAAGAT CCGAGCTAAA ATCCCAGGGA CCGGAGCCCT GGCCTCTGCA 
GCAGCCGCAG TCTCCGGATC CAAAGCCAAA GCCGAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_996783.1
CDS	231..1649
Translation	MGQVLPVFAHCKEAPSTASSTPDSTEGGNDDSDFRELHTAREFSEEDEEETTSQDWGTPRELTFSYIAFDGVVGSGGRRDSTARRPRPQGRSVSEPRDQHPQPSLGDSLESIPSLSQSPEPGRRGDPDTAPPSERPLEDLRLRLDHLGWVARGTGSGEDSSTSSSTPLEDEEPQEPNRLETGEAGEELDLRLRLAQPSSPEVLTPQLSPGSGTPQAGTPSPSRSRDSNSGPEEPLLEEEEKQWGPLEREPVRGQCLDSTDQLEFTVEPRLLVADLLYWKDTRTSGVVFTGLMVSLLCLLHFSIVSVAAHLALLLLCGTISLRVYRKVLQAVHRGDGANPFQAYLDVDLTLTREQTERLSHQITSRVVSAATQLRHFFLVEDLVDSLKLALLFYILTFVGAIFNGLTLLILGVIGLFTIPLLYRQHQAQIDQYVGLVTNQLSHIKAKIRAKIPGTGALASAAAAVSGSKAKAE

Target ORF information:

RefSeq Version	NM_206900.2
Organism	Homo sapiens(human)
Definition	Homo sapiens reticulon 2 (RTN2), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_206900.2

ORF Insert Sequence:

ATGGGGCAGG TCCTGCCGGT CTTCGCCCAC TGCAAAGAAG CTCCGTCTAC AGCCTCCTCA 
ACTCCTGATT CCACAGAAGG AGGGAACGAC GACTCTGATT TTCGAGAGCT GCACACAGCC 
CGGGAATTCT CAGAGGAGGA CGAGGAGGAG ACCACGTCGC AGGACTGGGG CACCCCCCGG 
GAGCTGACCT TCTCCTACAT CGCCTTTGAT GGTGTAGTGG GCTCCGGGGG CCGCAGGGAT 
TCAACTGCCC GCCGCCCCCG CCCCCAGGGC CGCTCAGTCT CGGAACCACG AGACCAGCAC 
CCTCAGCCCA GCCTGGGCGA CAGCTTGGAG AGCATCCCCA GCCTGAGCCA ATCCCCGGAG 
CCTGGACGAC GGGGTGATCC TGACACCGCG CCTCCATCCG AGCGCCCTCT GGAAGACCTG 
AGGCTTCGGT TGGACCATCT GGGCTGGGTG GCCCGGGGAA CGGGATCCGG GGAGGACTCT 
TCCACCAGCA GCTCCACCCC GCTGGAAGAC GAAGAACCCC AAGAACCCAA CAGATTGGAG 
ACAGGAGAAG CTGGGGAAGA ACTGGACCTA CGACTCCGAC TTGCTCAGCC CTCATCGCCC 
GAGGTCTTGA CTCCCCAGCT CAGTCCGGGC TCTGGGACAC CCCAGGCCGG TACTCCGTCC 
CCATCCCGAT CGCGAGATTC GAACTCTGGG CCCGAAGAGC CATTGCTGGA AGAGGAAGAA 
AAGCAGTGGG GGCCACTGGA GCGAGAGCCA GTAAGGGGAC AGTGCCTCGA TAGCACGGAC 
CAATTAGAAT TCACGGTGGA GCCACGCCTT CTAGTGGCGG ACCTGCTGTA CTGGAAGGAC 
ACGAGGACGT CAGGAGTGGT CTTCACAGGC CTGATGGTCT CCCTCCTCTG CCTCCTGCAC 
TTTAGCATCG TGTCCGTGGC CGCGCACTTG GCTCTGTTGC TGCTCTGCGG CACCATCTCT 
CTCAGGGTTT ACCGCAAAGT GCTGCAGGCC GTGCACCGGG GGGATGGAGC CAACCCTTTC 
CAGGCCTACC TGGATGTGGA CCTCACCCTG ACTCGGGAGC AGACGGAACG TTTGTCCCAC 
CAGATCACCT CCCGCGTGGT CTCGGCGGCC ACGCAGCTGC GGCACTTCTT CCTGGTAGAA 
GACCTCGTGG ATTCCCTCAA GCTGGCCCTC CTCTTCTACA TCTTGACCTT CGTGGGTGCC 
ATCTTCAATG GTTTGACTCT TCTCATTCTG GGAGTGATTG GTCTATTCAC CATCCCCCTG 
CTGTACCGGC AGCACCAGGC TCAGATCGAC CAATATGTGG GGTTGGTGAC CAATCAGTTG 
AGCCACATCA AAGCTAAGAT CCGAGCTAAA ATCCCAGGGA CCGGAGCCCT GGCCTCTGCA 
GCAGCCGCAG TCTCCGGATC CAAAGCCAAA GCCGAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RTN2 ( NM_206900.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_996783.1 Homo sapiens reticulon 2 (RTN2), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu03055
Clone ID Related Accession (Same CDS sequence)	NM_206900.2 , NM_206900.3
Accession Version	NM_206900.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1419bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-27
Organism	Homo sapiens(human)
Product	reticulon-2 isoform B
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BK001688.1 and BC073874.1. On Jun 1, 2019 this sequence version replaced NM_206900.2. Transcript Variant: This variant (2) lacks an in-frame segment of the coding region, compared to variant 1. It encodes a shorter isoform (B), that is missing an internal segment compared to isoform A. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BK001688.1, SRR3476690.758170.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGGCAGG TCCTGCCGGT CTTCGCCCAC TGCAAAGAAG CTCCGTCTAC AGCCTCCTCA 
ACTCCTGATT CCACAGAAGG AGGGAACGAC GACTCTGATT TTCGAGAGCT GCACACAGCC 
CGGGAATTCT CAGAGGAGGA CGAGGAGGAG ACCACGTCGC AGGACTGGGG CACCCCCCGG 
GAGCTGACCT TCTCCTACAT CGCCTTTGAT GGTGTAGTGG GCTCCGGGGG CCGCAGGGAT 
TCAACTGCCC GCCGCCCCCG CCCCCAGGGC CGCTCAGTCT CGGAACCACG AGACCAGCAC 
CCTCAGCCCA GCCTGGGCGA CAGCTTGGAG AGCATCCCCA GCCTGAGCCA ATCCCCGGAG 
CCTGGACGAC GGGGTGATCC TGACACCGCG CCTCCATCCG AGCGCCCTCT GGAAGACCTG 
AGGCTTCGGT TGGACCATCT GGGCTGGGTG GCCCGGGGAA CGGGATCCGG GGAGGACTCT 
TCCACCAGCA GCTCCACCCC GCTGGAAGAC GAAGAACCCC AAGAACCCAA CAGATTGGAG 
ACAGGAGAAG CTGGGGAAGA ACTGGACCTA CGACTCCGAC TTGCTCAGCC CTCATCGCCC 
GAGGTCTTGA CTCCCCAGCT CAGTCCGGGC TCTGGGACAC CCCAGGCCGG TACTCCGTCC 
CCATCCCGAT CGCGAGATTC GAACTCTGGG CCCGAAGAGC CATTGCTGGA AGAGGAAGAA 
AAGCAGTGGG GGCCACTGGA GCGAGAGCCA GTAAGGGGAC AGTGCCTCGA TAGCACGGAC 
CAATTAGAAT TCACGGTGGA GCCACGCCTT CTAGTGGCGG ACCTGCTGTA CTGGAAGGAC 
ACGAGGACGT CAGGAGTGGT CTTCACAGGC CTGATGGTCT CCCTCCTCTG CCTCCTGCAC 
TTTAGCATCG TGTCCGTGGC CGCGCACTTG GCTCTGTTGC TGCTCTGCGG CACCATCTCT 
CTCAGGGTTT ACCGCAAAGT GCTGCAGGCC GTGCACCGGG GGGATGGAGC CAACCCTTTC 
CAGGCCTACC TGGATGTGGA CCTCACCCTG ACTCGGGAGC AGACGGAACG TTTGTCCCAC 
CAGATCACCT CCCGCGTGGT CTCGGCGGCC ACGCAGCTGC GGCACTTCTT CCTGGTAGAA 
GACCTCGTGG ATTCCCTCAA GCTGGCCCTC CTCTTCTACA TCTTGACCTT CGTGGGTGCC 
ATCTTCAATG GTTTGACTCT TCTCATTCTG GGAGTGATTG GTCTATTCAC CATCCCCCTG 
CTGTACCGGC AGCACCAGGC TCAGATCGAC CAATATGTGG GGTTGGTGAC CAATCAGTTG 
AGCCACATCA AAGCTAAGAT CCGAGCTAAA ATCCCAGGGA CCGGAGCCCT GGCCTCTGCA 
GCAGCCGCAG TCTCCGGATC CAAAGCCAAA GCCGAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_996783.1
CDS	223..1641
Translation	MGQVLPVFAHCKEAPSTASSTPDSTEGGNDDSDFRELHTAREFSEEDEEETTSQDWGTPRELTFSYIAFDGVVGSGGRRDSTARRPRPQGRSVSEPRDQHPQPSLGDSLESIPSLSQSPEPGRRGDPDTAPPSERPLEDLRLRLDHLGWVARGTGSGEDSSTSSSTPLEDEEPQEPNRLETGEAGEELDLRLRLAQPSSPEVLTPQLSPGSGTPQAGTPSPSRSRDSNSGPEEPLLEEEEKQWGPLEREPVRGQCLDSTDQLEFTVEPRLLVADLLYWKDTRTSGVVFTGLMVSLLCLLHFSIVSVAAHLALLLLCGTISLRVYRKVLQAVHRGDGANPFQAYLDVDLTLTREQTERLSHQITSRVVSAATQLRHFFLVEDLVDSLKLALLFYILTFVGAIFNGLTLLILGVIGLFTIPLLYRQHQAQIDQYVGLVTNQLSHIKAKIRAKIPGTGALASAAAAVSGSKAKAE

Target ORF information:

RefSeq Version	NM_206900.3
Organism	Homo sapiens(human)
Definition	Homo sapiens reticulon 2 (RTN2), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_206900.3

ORF Insert Sequence:

ATGGGGCAGG TCCTGCCGGT CTTCGCCCAC TGCAAAGAAG CTCCGTCTAC AGCCTCCTCA 
ACTCCTGATT CCACAGAAGG AGGGAACGAC GACTCTGATT TTCGAGAGCT GCACACAGCC 
CGGGAATTCT CAGAGGAGGA CGAGGAGGAG ACCACGTCGC AGGACTGGGG CACCCCCCGG 
GAGCTGACCT TCTCCTACAT CGCCTTTGAT GGTGTAGTGG GCTCCGGGGG CCGCAGGGAT 
TCAACTGCCC GCCGCCCCCG CCCCCAGGGC CGCTCAGTCT CGGAACCACG AGACCAGCAC 
CCTCAGCCCA GCCTGGGCGA CAGCTTGGAG AGCATCCCCA GCCTGAGCCA ATCCCCGGAG 
CCTGGACGAC GGGGTGATCC TGACACCGCG CCTCCATCCG AGCGCCCTCT GGAAGACCTG 
AGGCTTCGGT TGGACCATCT GGGCTGGGTG GCCCGGGGAA CGGGATCCGG GGAGGACTCT 
TCCACCAGCA GCTCCACCCC GCTGGAAGAC GAAGAACCCC AAGAACCCAA CAGATTGGAG 
ACAGGAGAAG CTGGGGAAGA ACTGGACCTA CGACTCCGAC TTGCTCAGCC CTCATCGCCC 
GAGGTCTTGA CTCCCCAGCT CAGTCCGGGC TCTGGGACAC CCCAGGCCGG TACTCCGTCC 
CCATCCCGAT CGCGAGATTC GAACTCTGGG CCCGAAGAGC CATTGCTGGA AGAGGAAGAA 
AAGCAGTGGG GGCCACTGGA GCGAGAGCCA GTAAGGGGAC AGTGCCTCGA TAGCACGGAC 
CAATTAGAAT TCACGGTGGA GCCACGCCTT CTAGTGGCGG ACCTGCTGTA CTGGAAGGAC 
ACGAGGACGT CAGGAGTGGT CTTCACAGGC CTGATGGTCT CCCTCCTCTG CCTCCTGCAC 
TTTAGCATCG TGTCCGTGGC CGCGCACTTG GCTCTGTTGC TGCTCTGCGG CACCATCTCT 
CTCAGGGTTT ACCGCAAAGT GCTGCAGGCC GTGCACCGGG GGGATGGAGC CAACCCTTTC 
CAGGCCTACC TGGATGTGGA CCTCACCCTG ACTCGGGAGC AGACGGAACG TTTGTCCCAC 
CAGATCACCT CCCGCGTGGT CTCGGCGGCC ACGCAGCTGC GGCACTTCTT CCTGGTAGAA 
GACCTCGTGG ATTCCCTCAA GCTGGCCCTC CTCTTCTACA TCTTGACCTT CGTGGGTGCC 
ATCTTCAATG GTTTGACTCT TCTCATTCTG GGAGTGATTG GTCTATTCAC CATCCCCCTG 
CTGTACCGGC AGCACCAGGC TCAGATCGAC CAATATGTGG GGTTGGTGAC CAATCAGTTG 
AGCCACATCA AAGCTAAGAT CCGAGCTAAA ATCCCAGGGA CCGGAGCCCT GGCCTCTGCA 
GCAGCCGCAG TCTCCGGATC CAAAGCCAAA GCCGAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RTN2 ( NM_206901.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_996784.1 Homo sapiens reticulon 2 (RTN2), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu03056
Clone ID Related Accession (Same CDS sequence)	NM_206901.3 , NM_206901.2
Accession Version	NM_206901.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 618bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-27
Organism	Homo sapiens(human)
Product	reticulon-2 isoform C
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC138534.2, DA898294.1 and AF004224.1. On May 31, 2019 this sequence version replaced NM_206901.2. Transcript Variant: This variant (3) differs in the 5' UTR and the 5' coding region, compared to variant 1. The resulting isoform (C) has a shorter N-terminus when compared to isoform A, and is presumably transcribed from an internal promoter. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BK001686.1, AF004224.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGGAGTA AAGTGGCGGA CCTGCTGTAC TGGAAGGACA CGAGGACGTC AGGAGTGGTC 
TTCACAGGCC TGATGGTCTC CCTCCTCTGC CTCCTGCACT TTAGCATCGT GTCCGTGGCC 
GCGCACTTGG CTCTGTTGCT GCTCTGCGGC ACCATCTCTC TCAGGGTTTA CCGCAAAGTG 
CTGCAGGCCG TGCACCGGGG GGATGGAGCC AACCCTTTCC AGGCCTACCT GGATGTGGAC 
CTCACCCTGA CTCGGGAGCA GACGGAACGT TTGTCCCACC AGATCACCTC CCGCGTGGTC 
TCGGCGGCCA CGCAGCTGCG GCACTTCTTC CTGGTAGAAG ACCTCGTGGA TTCCCTCAAG 
CTGGCCCTCC TCTTCTACAT CTTGACCTTC GTGGGTGCCA TCTTCAATGG TTTGACTCTT 
CTCATTCTGG GAGTGATTGG TCTATTCACC ATCCCCCTGC TGTACCGGCA GCACCAGGCT 
CAGATCGACC AATATGTGGG GTTGGTGACC AATCAGTTGA GCCACATCAA AGCTAAGATC 
CGAGCTAAAA TCCCAGGGAC CGGAGCCCTG GCCTCTGCAG CAGCCGCAGT CTCCGGATCC 
AAAGCCAAAG CCGAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_996784.1
CDS	82..699
Translation	MGSKVADLLYWKDTRTSGVVFTGLMVSLLCLLHFSIVSVAAHLALLLLCGTISLRVYRKVLQAVHRGDGANPFQAYLDVDLTLTREQTERLSHQITSRVVSAATQLRHFFLVEDLVDSLKLALLFYILTFVGAIFNGLTLLILGVIGLFTIPLLYRQHQAQIDQYVGLVTNQLSHIKAKIRAKIPGTGALASAAAAVSGSKAKAE

Target ORF information:

RefSeq Version	NM_206901.3
Organism	Homo sapiens(human)
Definition	Homo sapiens reticulon 2 (RTN2), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_206901.3

ORF Insert Sequence:

ATGGGGAGTA AAGTGGCGGA CCTGCTGTAC TGGAAGGACA CGAGGACGTC AGGAGTGGTC 
TTCACAGGCC TGATGGTCTC CCTCCTCTGC CTCCTGCACT TTAGCATCGT GTCCGTGGCC 
GCGCACTTGG CTCTGTTGCT GCTCTGCGGC ACCATCTCTC TCAGGGTTTA CCGCAAAGTG 
CTGCAGGCCG TGCACCGGGG GGATGGAGCC AACCCTTTCC AGGCCTACCT GGATGTGGAC 
CTCACCCTGA CTCGGGAGCA GACGGAACGT TTGTCCCACC AGATCACCTC CCGCGTGGTC 
TCGGCGGCCA CGCAGCTGCG GCACTTCTTC CTGGTAGAAG ACCTCGTGGA TTCCCTCAAG 
CTGGCCCTCC TCTTCTACAT CTTGACCTTC GTGGGTGCCA TCTTCAATGG TTTGACTCTT 
CTCATTCTGG GAGTGATTGG TCTATTCACC ATCCCCCTGC TGTACCGGCA GCACCAGGCT 
CAGATCGACC AATATGTGGG GTTGGTGACC AATCAGTTGA GCCACATCAA AGCTAAGATC 
CGAGCTAAAA TCCCAGGGAC CGGAGCCCTG GCCTCTGCAG CAGCCGCAGT CTCCGGATCC 
AAAGCCAAAG CCGAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RTN2 ( NM_206901.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_996784.1 Homo sapiens reticulon 2 (RTN2), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu03056
Clone ID Related Accession (Same CDS sequence)	NM_206901.3 , NM_206901.2
Accession Version	NM_206901.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 618bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-22
Organism	Homo sapiens(human)
Product	reticulon-2 isoform C
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA898294.1, AF004224.1, AK291967.1 and AI971392.1. On Apr 10, 2012 this sequence version replaced NM_206901.1. Transcript Variant: This variant (3) differs in the 5' UTR and the 5' coding region, compared to variant 1. The resulting isoform (C) has a shorter N-terminus when compared to isoform A, and is presumably transcribed from an internal promoter. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163655.246747.1, SRR1163655.402086.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGGAGTA AAGTGGCGGA CCTGCTGTAC TGGAAGGACA CGAGGACGTC AGGAGTGGTC 
TTCACAGGCC TGATGGTCTC CCTCCTCTGC CTCCTGCACT TTAGCATCGT GTCCGTGGCC 
GCGCACTTGG CTCTGTTGCT GCTCTGCGGC ACCATCTCTC TCAGGGTTTA CCGCAAAGTG 
CTGCAGGCCG TGCACCGGGG GGATGGAGCC AACCCTTTCC AGGCCTACCT GGATGTGGAC 
CTCACCCTGA CTCGGGAGCA GACGGAACGT TTGTCCCACC AGATCACCTC CCGCGTGGTC 
TCGGCGGCCA CGCAGCTGCG GCACTTCTTC CTGGTAGAAG ACCTCGTGGA TTCCCTCAAG 
CTGGCCCTCC TCTTCTACAT CTTGACCTTC GTGGGTGCCA TCTTCAATGG TTTGACTCTT 
CTCATTCTGG GAGTGATTGG TCTATTCACC ATCCCCCTGC TGTACCGGCA GCACCAGGCT 
CAGATCGACC AATATGTGGG GTTGGTGACC AATCAGTTGA GCCACATCAA AGCTAAGATC 
CGAGCTAAAA TCCCAGGGAC CGGAGCCCTG GCCTCTGCAG CAGCCGCAGT CTCCGGATCC 
AAAGCCAAAG CCGAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_996784.1
CDS	74..691
Translation	MGSKVADLLYWKDTRTSGVVFTGLMVSLLCLLHFSIVSVAAHLALLLLCGTISLRVYRKVLQAVHRGDGANPFQAYLDVDLTLTREQTERLSHQITSRVVSAATQLRHFFLVEDLVDSLKLALLFYILTFVGAIFNGLTLLILGVIGLFTIPLLYRQHQAQIDQYVGLVTNQLSHIKAKIRAKIPGTGALASAAAAVSGSKAKAE

Target ORF information:

RefSeq Version	NM_206901.2
Organism	Homo sapiens(human)
Definition	Homo sapiens reticulon 2 (RTN2), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_206901.2

ORF Insert Sequence:

ATGGGGAGTA AAGTGGCGGA CCTGCTGTAC TGGAAGGACA CGAGGACGTC AGGAGTGGTC 
TTCACAGGCC TGATGGTCTC CCTCCTCTGC CTCCTGCACT TTAGCATCGT GTCCGTGGCC 
GCGCACTTGG CTCTGTTGCT GCTCTGCGGC ACCATCTCTC TCAGGGTTTA CCGCAAAGTG 
CTGCAGGCCG TGCACCGGGG GGATGGAGCC AACCCTTTCC AGGCCTACCT GGATGTGGAC 
CTCACCCTGA CTCGGGAGCA GACGGAACGT TTGTCCCACC AGATCACCTC CCGCGTGGTC 
TCGGCGGCCA CGCAGCTGCG GCACTTCTTC CTGGTAGAAG ACCTCGTGGA TTCCCTCAAG 
CTGGCCCTCC TCTTCTACAT CTTGACCTTC GTGGGTGCCA TCTTCAATGG TTTGACTCTT 
CTCATTCTGG GAGTGATTGG TCTATTCACC ATCCCCCTGC TGTACCGGCA GCACCAGGCT 
CAGATCGACC AATATGTGGG GTTGGTGACC AATCAGTTGA GCCACATCAA AGCTAAGATC 
CGAGCTAAAA TCCCAGGGAC CGGAGCCCTG GCCTCTGCAG CAGCCGCAGT CTCCGGATCC 
AAAGCCAAAG CCGAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RTN2 ( NM_005619.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_005610.1 Homo sapiens reticulon 2 (RTN2), transcript variant 1, mRNA.

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CloneID	OHu20336
Clone ID Related Accession (Same CDS sequence)	NM_005619.4 , NM_005619.5
Accession Version	NM_005619.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1638bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-02
Organism	Homo sapiens(human)
Product	reticulon-2 isoform A
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BK001687.1, BC073874.1, AF004222.1, AK291967.1 and AI971392.1. This sequence is a reference standard in the RefSeqGene project. On Apr 10, 2012 this sequence version replaced NM_005619.3. Transcript Variant: This variant (1) represents the longest transcript, and encodes the longest isoform (A). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BK001687.1, BC073874.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGGCAGG TCCTGCCGGT CTTCGCCCAC TGCAAAGAAG CTCCGTCTAC AGCCTCCTCA 
ACTCCTGATT CCACAGAAGG AGGGAACGAC GACTCTGATT TTCGAGAGCT GCACACAGCC 
CGGGAATTCT CAGAGGAGGA CGAGGAGGAG ACCACGTCGC AGGACTGGGG CACCCCCCGG 
GAGCTGACCT TCTCCTACAT CGCCTTTGAT GGTGTAGTGG GCTCCGGGGG CCGCAGGGAT 
TCAACTGCCC GCCGCCCCCG CCCCCAGGGC CGCTCAGTCT CGGAACCACG AGACCAGCAC 
CCTCAGCCCA GCCTGGGCGA CAGCTTGGAG AGCATCCCCA GCCTGAGCCA ATCCCCGGAG 
CCTGGACGAC GGGGTGATCC TGACACCGCG CCTCCATCCG AGCGCCCTCT GGAAGACCTG 
AGGCTTCGGT TGGACCATCT GGGCTGGGTG GCCCGGGGAA CGGGATCCGG GGAGGACTCT 
TCCACCAGCA GCTCCACCCC GCTGGAAGAC GAAGAACCCC AAGAACCCAA CAGATTGGAG 
ACAGGAGAAG CTGGGGAAGA ACTGGACCTA CGACTCCGAC TTGCTCAGCC CTCATCGCCC 
GAGGTCTTGA CTCCCCAGCT CAGTCCGGGC TCTGGGACAC CCCAGGCCGG TACTCCGTCC 
CCATCCCGAT CGCGAGATTC GAACTCTGGG CCCGAAGAGC CATTGCTGGA AGAGGAAGAA 
AAGCAGTGGG GGCCACTGGA GCGAGAGCCA GTAAGGGGAC AGTGCCTCGA TAGCACGGAC 
CAATTAGAAT TCACGGTGGA GCCACGCCTT CTAGGAACAG CTATGGAATG GTTAAAGACA 
TCATTGCTTT TGGCTGTTTA CAAGACGGTT CCAATTTTGG AATTGTCCCC ACCTCTGTGG 
ACAGCCATTG GCTGGGTCCA AAGGGGCCCC ACCCCCCCTA CTCCTGTCCT CCGGGTTCTA 
CTGAAGTGGG CAAAATCCCC GAGAAGCAGC GGTGTCCCCA GCCTCTCACT CGGAGCCGAT 
ATGGGGAGTA AAGTGGCGGA CCTGCTGTAC TGGAAGGACA CGAGGACGTC AGGAGTGGTC 
TTCACAGGCC TGATGGTCTC CCTCCTCTGC CTCCTGCACT TTAGCATCGT GTCCGTGGCC 
GCGCACTTGG CTCTGTTGCT GCTCTGCGGC ACCATCTCTC TCAGGGTTTA CCGCAAAGTG 
CTGCAGGCCG TGCACCGGGG GGATGGAGCC AACCCTTTCC AGGCCTACCT GGATGTGGAC 
CTCACCCTGA CTCGGGAGCA GACGGAACGT TTGTCCCACC AGATCACCTC CCGCGTGGTC 
TCGGCGGCCA CGCAGCTGCG GCACTTCTTC CTGGTAGAAG ACCTCGTGGA TTCCCTCAAG 
CTGGCCCTCC TCTTCTACAT CTTGACCTTC GTGGGTGCCA TCTTCAATGG TTTGACTCTT 
CTCATTCTGG GAGTGATTGG TCTATTCACC ATCCCCCTGC TGTACCGGCA GCACCAGGCT 
CAGATCGACC AATATGTGGG GTTGGTGACC AATCAGTTGA GCCACATCAA AGCTAAGATC 
CGAGCTAAAA TCCCAGGGAC CGGAGCCCTG GCCTCTGCAG CAGCCGCAGT CTCCGGATCC 
AAAGCCAAAG CCGAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005610.1
CDS	231..1868
Translation	MGQVLPVFAHCKEAPSTASSTPDSTEGGNDDSDFRELHTAREFSEEDEEETTSQDWGTPRELTFSYIAFDGVVGSGGRRDSTARRPRPQGRSVSEPRDQHPQPSLGDSLESIPSLSQSPEPGRRGDPDTAPPSERPLEDLRLRLDHLGWVARGTGSGEDSSTSSSTPLEDEEPQEPNRLETGEAGEELDLRLRLAQPSSPEVLTPQLSPGSGTPQAGTPSPSRSRDSNSGPEEPLLEEEEKQWGPLEREPVRGQCLDSTDQLEFTVEPRLLGTAMEWLKTSLLLAVYKTVPILELSPPLWTAIGWVQRGPTPPTPVLRVLLKWAKSPRSSGVPSLSLGADMGSKVADLLYWKDTRTSGVVFTGLMVSLLCLLHFSIVSVAAHLALLLLCGTISLRVYRKVLQAVHRGDGANPFQAYLDVDLTLTREQTERLSHQITSRVVSAATQLRHFFLVEDLVDSLKLALLFYILTFVGAIFNGLTLLILGVIGLFTIPLLYRQHQAQIDQYVGLVTNQLSHIKAKIRAKIPGTGALASAAAAVSGSKAKAE

Target ORF information:

RefSeq Version	NM_005619.4
Organism	Homo sapiens(human)
Definition	Homo sapiens reticulon 2 (RTN2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005619.4

ORF Insert Sequence:

ATGGGGCAGG TCCTGCCGGT CTTCGCCCAC TGCAAAGAAG CTCCGTCTAC AGCCTCCTCA 
ACTCCTGATT CCACAGAAGG AGGGAACGAC GACTCTGATT TTCGAGAGCT GCACACAGCC 
CGGGAATTCT CAGAGGAGGA CGAGGAGGAG ACCACGTCGC AGGACTGGGG CACCCCCCGG 
GAGCTGACCT TCTCCTACAT CGCCTTTGAT GGTGTAGTGG GCTCCGGGGG CCGCAGGGAT 
TCAACTGCCC GCCGCCCCCG CCCCCAGGGC CGCTCAGTCT CGGAACCACG AGACCAGCAC 
CCTCAGCCCA GCCTGGGCGA CAGCTTGGAG AGCATCCCCA GCCTGAGCCA ATCCCCGGAG 
CCTGGACGAC GGGGTGATCC TGACACCGCG CCTCCATCCG AGCGCCCTCT GGAAGACCTG 
AGGCTTCGGT TGGACCATCT GGGCTGGGTG GCCCGGGGAA CGGGATCCGG GGAGGACTCT 
TCCACCAGCA GCTCCACCCC GCTGGAAGAC GAAGAACCCC AAGAACCCAA CAGATTGGAG 
ACAGGAGAAG CTGGGGAAGA ACTGGACCTA CGACTCCGAC TTGCTCAGCC CTCATCGCCC 
GAGGTCTTGA CTCCCCAGCT CAGTCCGGGC TCTGGGACAC CCCAGGCCGG TACTCCGTCC 
CCATCCCGAT CGCGAGATTC GAACTCTGGG CCCGAAGAGC CATTGCTGGA AGAGGAAGAA 
AAGCAGTGGG GGCCACTGGA GCGAGAGCCA GTAAGGGGAC AGTGCCTCGA TAGCACGGAC 
CAATTAGAAT TCACGGTGGA GCCACGCCTT CTAGGAACAG CTATGGAATG GTTAAAGACA 
TCATTGCTTT TGGCTGTTTA CAAGACGGTT CCAATTTTGG AATTGTCCCC ACCTCTGTGG 
ACAGCCATTG GCTGGGTCCA AAGGGGCCCC ACCCCCCCTA CTCCTGTCCT CCGGGTTCTA 
CTGAAGTGGG CAAAATCCCC GAGAAGCAGC GGTGTCCCCA GCCTCTCACT CGGAGCCGAT 
ATGGGGAGTA AAGTGGCGGA CCTGCTGTAC TGGAAGGACA CGAGGACGTC AGGAGTGGTC 
TTCACAGGCC TGATGGTCTC CCTCCTCTGC CTCCTGCACT TTAGCATCGT GTCCGTGGCC 
GCGCACTTGG CTCTGTTGCT GCTCTGCGGC ACCATCTCTC TCAGGGTTTA CCGCAAAGTG 
CTGCAGGCCG TGCACCGGGG GGATGGAGCC AACCCTTTCC AGGCCTACCT GGATGTGGAC 
CTCACCCTGA CTCGGGAGCA GACGGAACGT TTGTCCCACC AGATCACCTC CCGCGTGGTC 
TCGGCGGCCA CGCAGCTGCG GCACTTCTTC CTGGTAGAAG ACCTCGTGGA TTCCCTCAAG 
CTGGCCCTCC TCTTCTACAT CTTGACCTTC GTGGGTGCCA TCTTCAATGG TTTGACTCTT 
CTCATTCTGG GAGTGATTGG TCTATTCACC ATCCCCCTGC TGTACCGGCA GCACCAGGCT 
CAGATCGACC AATATGTGGG GTTGGTGACC AATCAGTTGA GCCACATCAA AGCTAAGATC 
CGAGCTAAAA TCCCAGGGAC CGGAGCCCTG GCCTCTGCAG CAGCCGCAGT CTCCGGATCC 
AAAGCCAAAG CCGAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RTN2 ( NM_005619.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_005610.1 Homo sapiens reticulon 2 (RTN2), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu20336
Clone ID Related Accession (Same CDS sequence)	NM_005619.4 , NM_005619.5
Accession Version	NM_005619.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1638bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-25
Organism	Homo sapiens(human)
Product	reticulon-2 isoform A
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BK001687.1, BC073874.1 and AF004222.1. This sequence is a reference standard in the RefSeqGene project. On Nov 22, 2018 this sequence version replaced NM_005619.4. Transcript Variant: This variant (1) represents the longest transcript, and encodes the longest isoform (A). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BK001687.1, BC073874.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000245923.9/ ENSP00000245923.3 RefSeq Select criteria :: based on conservation, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGGGCAGG TCCTGCCGGT CTTCGCCCAC TGCAAAGAAG CTCCGTCTAC AGCCTCCTCA 
ACTCCTGATT CCACAGAAGG AGGGAACGAC GACTCTGATT TTCGAGAGCT GCACACAGCC 
CGGGAATTCT CAGAGGAGGA CGAGGAGGAG ACCACGTCGC AGGACTGGGG CACCCCCCGG 
GAGCTGACCT TCTCCTACAT CGCCTTTGAT GGTGTAGTGG GCTCCGGGGG CCGCAGGGAT 
TCAACTGCCC GCCGCCCCCG CCCCCAGGGC CGCTCAGTCT CGGAACCACG AGACCAGCAC 
CCTCAGCCCA GCCTGGGCGA CAGCTTGGAG AGCATCCCCA GCCTGAGCCA ATCCCCGGAG 
CCTGGACGAC GGGGTGATCC TGACACCGCG CCTCCATCCG AGCGCCCTCT GGAAGACCTG 
AGGCTTCGGT TGGACCATCT GGGCTGGGTG GCCCGGGGAA CGGGATCCGG GGAGGACTCT 
TCCACCAGCA GCTCCACCCC GCTGGAAGAC GAAGAACCCC AAGAACCCAA CAGATTGGAG 
ACAGGAGAAG CTGGGGAAGA ACTGGACCTA CGACTCCGAC TTGCTCAGCC CTCATCGCCC 
GAGGTCTTGA CTCCCCAGCT CAGTCCGGGC TCTGGGACAC CCCAGGCCGG TACTCCGTCC 
CCATCCCGAT CGCGAGATTC GAACTCTGGG CCCGAAGAGC CATTGCTGGA AGAGGAAGAA 
AAGCAGTGGG GGCCACTGGA GCGAGAGCCA GTAAGGGGAC AGTGCCTCGA TAGCACGGAC 
CAATTAGAAT TCACGGTGGA GCCACGCCTT CTAGGAACAG CTATGGAATG GTTAAAGACA 
TCATTGCTTT TGGCTGTTTA CAAGACGGTT CCAATTTTGG AATTGTCCCC ACCTCTGTGG 
ACAGCCATTG GCTGGGTCCA AAGGGGCCCC ACCCCCCCTA CTCCTGTCCT CCGGGTTCTA 
CTGAAGTGGG CAAAATCCCC GAGAAGCAGC GGTGTCCCCA GCCTCTCACT CGGAGCCGAT 
ATGGGGAGTA AAGTGGCGGA CCTGCTGTAC TGGAAGGACA CGAGGACGTC AGGAGTGGTC 
TTCACAGGCC TGATGGTCTC CCTCCTCTGC CTCCTGCACT TTAGCATCGT GTCCGTGGCC 
GCGCACTTGG CTCTGTTGCT GCTCTGCGGC ACCATCTCTC TCAGGGTTTA CCGCAAAGTG 
CTGCAGGCCG TGCACCGGGG GGATGGAGCC AACCCTTTCC AGGCCTACCT GGATGTGGAC 
CTCACCCTGA CTCGGGAGCA GACGGAACGT TTGTCCCACC AGATCACCTC CCGCGTGGTC 
TCGGCGGCCA CGCAGCTGCG GCACTTCTTC CTGGTAGAAG ACCTCGTGGA TTCCCTCAAG 
CTGGCCCTCC TCTTCTACAT CTTGACCTTC GTGGGTGCCA TCTTCAATGG TTTGACTCTT 
CTCATTCTGG GAGTGATTGG TCTATTCACC ATCCCCCTGC TGTACCGGCA GCACCAGGCT 
CAGATCGACC AATATGTGGG GTTGGTGACC AATCAGTTGA GCCACATCAA AGCTAAGATC 
CGAGCTAAAA TCCCAGGGAC CGGAGCCCTG GCCTCTGCAG CAGCCGCAGT CTCCGGATCC 
AAAGCCAAAG CCGAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005610.1
CDS	223..1860
Translation	MGQVLPVFAHCKEAPSTASSTPDSTEGGNDDSDFRELHTAREFSEEDEEETTSQDWGTPRELTFSYIAFDGVVGSGGRRDSTARRPRPQGRSVSEPRDQHPQPSLGDSLESIPSLSQSPEPGRRGDPDTAPPSERPLEDLRLRLDHLGWVARGTGSGEDSSTSSSTPLEDEEPQEPNRLETGEAGEELDLRLRLAQPSSPEVLTPQLSPGSGTPQAGTPSPSRSRDSNSGPEEPLLEEEEKQWGPLEREPVRGQCLDSTDQLEFTVEPRLLGTAMEWLKTSLLLAVYKTVPILELSPPLWTAIGWVQRGPTPPTPVLRVLLKWAKSPRSSGVPSLSLGADMGSKVADLLYWKDTRTSGVVFTGLMVSLLCLLHFSIVSVAAHLALLLLCGTISLRVYRKVLQAVHRGDGANPFQAYLDVDLTLTREQTERLSHQITSRVVSAATQLRHFFLVEDLVDSLKLALLFYILTFVGAIFNGLTLLILGVIGLFTIPLLYRQHQAQIDQYVGLVTNQLSHIKAKIRAKIPGTGALASAAAAVSGSKAKAE

Target ORF information:

RefSeq Version	NM_005619.5
Organism	Homo sapiens(human)
Definition	Homo sapiens reticulon 2 (RTN2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005619.5

ORF Insert Sequence:

ATGGGGCAGG TCCTGCCGGT CTTCGCCCAC TGCAAAGAAG CTCCGTCTAC AGCCTCCTCA 
ACTCCTGATT CCACAGAAGG AGGGAACGAC GACTCTGATT TTCGAGAGCT GCACACAGCC 
CGGGAATTCT CAGAGGAGGA CGAGGAGGAG ACCACGTCGC AGGACTGGGG CACCCCCCGG 
GAGCTGACCT TCTCCTACAT CGCCTTTGAT GGTGTAGTGG GCTCCGGGGG CCGCAGGGAT 
TCAACTGCCC GCCGCCCCCG CCCCCAGGGC CGCTCAGTCT CGGAACCACG AGACCAGCAC 
CCTCAGCCCA GCCTGGGCGA CAGCTTGGAG AGCATCCCCA GCCTGAGCCA ATCCCCGGAG 
CCTGGACGAC GGGGTGATCC TGACACCGCG CCTCCATCCG AGCGCCCTCT GGAAGACCTG 
AGGCTTCGGT TGGACCATCT GGGCTGGGTG GCCCGGGGAA CGGGATCCGG GGAGGACTCT 
TCCACCAGCA GCTCCACCCC GCTGGAAGAC GAAGAACCCC AAGAACCCAA CAGATTGGAG 
ACAGGAGAAG CTGGGGAAGA ACTGGACCTA CGACTCCGAC TTGCTCAGCC CTCATCGCCC 
GAGGTCTTGA CTCCCCAGCT CAGTCCGGGC TCTGGGACAC CCCAGGCCGG TACTCCGTCC 
CCATCCCGAT CGCGAGATTC GAACTCTGGG CCCGAAGAGC CATTGCTGGA AGAGGAAGAA 
AAGCAGTGGG GGCCACTGGA GCGAGAGCCA GTAAGGGGAC AGTGCCTCGA TAGCACGGAC 
CAATTAGAAT TCACGGTGGA GCCACGCCTT CTAGGAACAG CTATGGAATG GTTAAAGACA 
TCATTGCTTT TGGCTGTTTA CAAGACGGTT CCAATTTTGG AATTGTCCCC ACCTCTGTGG 
ACAGCCATTG GCTGGGTCCA AAGGGGCCCC ACCCCCCCTA CTCCTGTCCT CCGGGTTCTA 
CTGAAGTGGG CAAAATCCCC GAGAAGCAGC GGTGTCCCCA GCCTCTCACT CGGAGCCGAT 
ATGGGGAGTA AAGTGGCGGA CCTGCTGTAC TGGAAGGACA CGAGGACGTC AGGAGTGGTC 
TTCACAGGCC TGATGGTCTC CCTCCTCTGC CTCCTGCACT TTAGCATCGT GTCCGTGGCC 
GCGCACTTGG CTCTGTTGCT GCTCTGCGGC ACCATCTCTC TCAGGGTTTA CCGCAAAGTG 
CTGCAGGCCG TGCACCGGGG GGATGGAGCC AACCCTTTCC AGGCCTACCT GGATGTGGAC 
CTCACCCTGA CTCGGGAGCA GACGGAACGT TTGTCCCACC AGATCACCTC CCGCGTGGTC 
TCGGCGGCCA CGCAGCTGCG GCACTTCTTC CTGGTAGAAG ACCTCGTGGA TTCCCTCAAG 
CTGGCCCTCC TCTTCTACAT CTTGACCTTC GTGGGTGCCA TCTTCAATGG TTTGACTCTT 
CTCATTCTGG GAGTGATTGG TCTATTCACC ATCCCCCTGC TGTACCGGCA GCACCAGGCT 
CAGATCGACC AATATGTGGG GTTGGTGACC AATCAGTTGA GCCACATCAA AGCTAAGATC 
CGAGCTAAAA TCCCAGGGAC CGGAGCCCTG GCCTCTGCAG CAGCCGCAGT CTCCGGATCC 
AAAGCCAAAG CCGAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Identification and characterization of TMEM33 as a reticulon-binding protein.
The Kobe journal of medical sciences60(3)E57-65(2014 Nov)
Urade T,Yamamoto Y,Zhang X,Ku Y,Sakisaka T

Mutations in the ER-shaping protein reticulon 2 cause the axon-degenerative disorder hereditary spastic paraplegia type 12.
The Journal of clinical investigation122(2)538-44(2012 Feb)
Montenegro G,Rebelo AP,Connell J,Allison R,Babalini C,D'Aloia M,Montieri P,Sch?le R,Ishiura H,Price J,Strickland A,Gonzalez MA,Baumbach-Reardon L,Deconinck T,Huang J,Bernardi G,Vance JM,Rogers MT,Tsuji S,De Jonghe P,Pericak-Vance MA,Sch?ls L,Orlacchio A,Reid E,Z?chner S

Functional role of neuroendocrine-specific protein-like 1 in membrane translocation of GLUT4.
Diabetes58(12)2802-12(2009 Dec)
Ikemoto T,Hosoya T,Takata K,Aoyama H,Hiramatsu T,Onoe H,Suzuki M,Endo M

Reticulon RTN2B regulates trafficking and function of neuronal glutamate transporter EAAC1.
The Journal of biological chemistry283(10)6561-71(2008 Mar)
Liu Y,Vidensky S,Ruggiero AM,Maier S,Sitte HH,Rothstein JD

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RTN2 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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