RPL18A cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	RPL18A
Entrez Gene ID	6142
Full Name	ribosomal protein L18a
Synonyms	L18A
General protein information	Preferred Names ribosomal protein L18a Names 60S ribosomal protein L18a large ribosomal subunit protein eL20 ribosomal protein L18a-like protein
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 19 Map Location: 19p13.11
Summary	Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a member of the L18AE family of ribosomal proteins that is a component of the 60S subunit. The encoded protein may play a role in viral replication by interacting with the hepatitis C virus internal ribosome entry site (IRES). This gene is co-transcribed with the U68 snoRNA, located within the third intron. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed throughout the genome. [provided by RefSeq, Jul 2012].
Disorder MIM:	604178

mRNA and Protein(s)

mRNA	Protein	Name
NM_000980.4	NP_000971.1	60S ribosomal protein L18a
NM_000980.3	NP_000971.1	60S ribosomal protein L18a

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	RPL18A	XP_533877.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP012284	XP_320252.4
Saccharomyces cerevisiae (baker's yeast)	RPL20A	NP_013969.3
Saccharomyces cerevisiae (baker's yeast)	RPL20B	NP_014957.2
Oryza sativa (rice)	Os01g0666900	NP_001043805.2
Oryza sativa (rice)	Os01g0752300	NP_001044264.1
Bos taurus (cattle)	RPL18A	NP_001028791.1
Danio rerio (zebrafish)	rpl18a	NP_957354.1
Arabidopsis thaliana (thale cress)	RPL18AA	NP_001077626.1
Arabidopsis thaliana (thale cress)	AT1G29965	NP_849729.1
Arabidopsis thaliana (thale cress)	AT2G34480	NP_180995.1
Homo sapiens (human)	RPL18A	NP_000971.1
Pan troglodytes (chimpanzee)	RPL18A	NP_001238961.1
Mus musculus (house mouse)	Rpl18a	NP_084027.1
Rattus norvegicus (Norway rat)	Rpl18a	NP_997675.1
Drosophila melanogaster (fruit fly)	RpL18A	NP_523774.1
Kluyveromyces lactis	KLLA0F08657g	XP_455473.2
Eremothecium gossypii	AGOS_AFR330C	NP_985877.3
Schizosaccharomyces pombe (fission yeast)	rpl2002	NP_594147.1
Magnaporthe oryzae (rice blast fungus)	MGG_03653	XP_003716235.1
Neurospora crassa	NCU08389	XP_963936.2
Arabidopsis thaliana (thale cress)	AT3G14600	NP_188078.1
	LOC719242	XP_002808227.1
Gallus gallus (chicken)	RPL18A	XP_416064.3
Schizosaccharomyces pombe (fission yeast)	rpl2001	NP_593336.1
Oryza sativa (rice)	Os05g0565000	NP_001056335.1
Xenopus tropicalis (tropical clawed frog)	rpl18a	NP_001016690.1

Gene Ontology
Bibliography

Related articles in PubMed

Architecture of the human interactome defines protein communities and disease networks.
Huttlin EL, Bruckner RJ, Paulo JA, Cannon JR, Ting L, Baltier K, Colby G, Gebreab F, Gygi MP, Parzen H, Szpyt J, Tam S, Zarraga G, Pontano-Vaites L, Swarup S, White AE, Schweppe DK, Rad R, Erickson BK, Obar RA, Guruharsha KG, Li K, Artavanis-Tsakonas S, Gygi SP, Harper JW
Nature545(7655)505-509(2017 05)

Structural snapshots of actively translating human ribosomes.
Behrmann E, Loerke J, Budkevich TV, Yamamoto K, Schmidt A, Penczek PA, Vos MR, B?rger J, Mielke T, Scheerer P, Spahn CM
Cell161(4)845-57(2015 May)

Host factors that interact with the pestivirus N-terminal protease, Npro, are components of the ribonucleoprotein complex.
Jefferson M, Donaszi-Ivanov A, Pollen S, Dalmay T, Saalbach G, Powell PP
Journal of virology88(18)10340-53(2014 Sep)

The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.
Baltz AG, Munschauer M, Schwanh?usser B, Vasile A, Murakawa Y, Schueler M, Youngs N, Penfold-Brown D, Drew K, Milek M, Wyler E, Bonneau R, Selbach M, Dieterich C, Landthaler M
Molecular cell46(5)674-90(2012 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

L18a might influence the HCV IRES mediated translation.
Title: Human ribosomal protein L18a interacts with hepatitis C virus internal ribosome entry site.

The following RPL18A gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the RPL18A cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu56042	NM_000980.4 Latest version!	Homo sapiens ribosomal protein L18a (RPL18A), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu56042	NM_000980.3	Homo sapiens ribosomal protein L18a (RPL18A), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

RPL18A ( NM_000980.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_000971.1 Homo sapiens ribosomal protein L18a (RPL18A), mRNA.

Price & Availability↑

CloneID	OHu56042
Clone ID Related Accession (Same CDS sequence)	NM_000980.4 , NM_000980.3
Accession Version	NM_000980.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 531bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-09
Organism	Homo sapiens(human)
Product	60S ribosomal protein L18a
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff in collaboration with Francesco Amaldi. The reference sequence was derived from HY050156.1, BC007512.2 and BI753938.1. On Nov 22, 2018 this sequence version replaced NM_000980.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: CD174123.1, CD173034.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000222247.10/ ENSP00000222247.4 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGAAGGCCT CGGGCACGCT ACGAGAGTAC AAGGTAGTGG GTCGCTGCCT GCCCACCCCC 
AAATGCCACA CGCCGCCCCT CTACCGCATG CGAATCTTTG CGCCTAATCA TGTCGTCGCC 
AAGTCCCGCT TCTGGTACTT TGTATCTCAG TTAAAGAAGA TGAAGAAGTC TTCAGGGGAG 
ATTGTCTACT GTGGGCAGGT GTTTGAGAAG TCCCCCCTGC GGGTGAAGAA CTTCGGGATC 
TGGCTGCGCT ATGACTCCCG GAGCGGCACC CACAACATGT ACCGGGAATA CCGGGACCTG 
ACCACCGCAG GCGCTGTCAC CCAGTGCTAC CGAGACATGG GTGCCCGGCA CCGCGCCCGA 
GCCCACTCCA TTCAGATCAT GAAGGTGGAG GAGATCGCGG CCAGCAAGTG CCGCCGGCCG 
GCTGTCAAGC AGTTCCACGA CTCCAAGATC AAGTTCCCGC TGCCCCACCG GGTCCTGCGC 
CGTCAGCACA AGCCACGCTT CACCACCAAG AGGCCCAACA CCTTCTTCTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000971.1
CDS	48..578
Translation	MKASGTLREYKVVGRCLPTPKCHTPPLYRMRIFAPNHVVAKSRFWYFVSQLKKMKKSSGEIVYCGQVFEKSPLRVKNFGIWLRYDSRSGTHNMYREYRDLTTAGAVTQCYRDMGARHRARAHSIQIMKVEEIAASKCRRPAVKQFHDSKIKFPLPHRVLRRQHKPRFTTKRPNTFF

Target ORF information:

RefSeq Version	NM_000980.4
Organism	Homo sapiens(human)
Definition	Homo sapiens ribosomal protein L18a (RPL18A), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000980.4

ORF Insert Sequence:

ATGAAGGCCT CGGGCACGCT ACGAGAGTAC AAGGTAGTGG GTCGCTGCCT GCCCACCCCC 
AAATGCCACA CGCCGCCCCT CTACCGCATG CGAATCTTTG CGCCTAATCA TGTCGTCGCC 
AAGTCCCGCT TCTGGTACTT TGTATCTCAG TTAAAGAAGA TGAAGAAGTC TTCAGGGGAG 
ATTGTCTACT GTGGGCAGGT GTTTGAGAAG TCCCCCCTGC GGGTGAAGAA CTTCGGGATC 
TGGCTGCGCT ATGACTCCCG GAGCGGCACC CACAACATGT ACCGGGAATA CCGGGACCTG 
ACCACCGCAG GCGCTGTCAC CCAGTGCTAC CGAGACATGG GTGCCCGGCA CCGCGCCCGA 
GCCCACTCCA TTCAGATCAT GAAGGTGGAG GAGATCGCGG CCAGCAAGTG CCGCCGGCCG 
GCTGTCAAGC AGTTCCACGA CTCCAAGATC AAGTTCCCGC TGCCCCACCG GGTCCTGCGC 
CGTCAGCACA AGCCACGCTT CACCACCAAG AGGCCCAACA CCTTCTTCTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RPL18A ( NM_000980.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_000971.1 Homo sapiens ribosomal protein L18a (RPL18A), mRNA.

Price & Availability↑

CloneID	OHu56042
Clone ID Related Accession (Same CDS sequence)	NM_000980.4 , NM_000980.3
Accession Version	NM_000980.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 531bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	60S ribosomal protein L18a
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff in collaboration with Francesco Amaldi. The reference sequence was derived from HY050156.1, BC007512.2 and BI753938.1. On Jul 12, 2012 this sequence version replaced NM_000980.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163655.57097.1, SRR1163657.472839.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

ATGAAGGCCT CGGGCACGCT ACGAGAGTAC AAGGTAGTGG GTCGCTGCCT GCCCACCCCC 
AAATGCCACA CGCCGCCCCT CTACCGCATG CGAATCTTTG CGCCTAATCA TGTCGTCGCC 
AAGTCCCGCT TCTGGTACTT TGTATCTCAG TTAAAGAAGA TGAAGAAGTC TTCAGGGGAG 
ATTGTCTACT GTGGGCAGGT GTTTGAGAAG TCCCCCCTGC GGGTGAAGAA CTTCGGGATC 
TGGCTGCGCT ATGACTCCCG GAGCGGCACC CACAACATGT ACCGGGAATA CCGGGACCTG 
ACCACCGCAG GCGCTGTCAC CCAGTGCTAC CGAGACATGG GTGCCCGGCA CCGCGCCCGA 
GCCCACTCCA TTCAGATCAT GAAGGTGGAG GAGATCGCGG CCAGCAAGTG CCGCCGGCCG 
GCTGTCAAGC AGTTCCACGA CTCCAAGATC AAGTTCCCGC TGCCCCACCG GGTCCTGCGC 
CGTCAGCACA AGCCACGCTT CACCACCAAG AGGCCCAACA CCTTCTTCTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000971.1
CDS	80..610
Translation	MKASGTLREYKVVGRCLPTPKCHTPPLYRMRIFAPNHVVAKSRFWYFVSQLKKMKKSSGEIVYCGQVFEKSPLRVKNFGIWLRYDSRSGTHNMYREYRDLTTAGAVTQCYRDMGARHRARAHSIQIMKVEEIAASKCRRPAVKQFHDSKIKFPLPHRVLRRQHKPRFTTKRPNTFF

Target ORF information:

RefSeq Version	NM_000980.3
Organism	Homo sapiens(human)
Definition	Homo sapiens ribosomal protein L18a (RPL18A), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000980.3

ORF Insert Sequence:

ATGAAGGCCT CGGGCACGCT ACGAGAGTAC AAGGTAGTGG GTCGCTGCCT GCCCACCCCC 
AAATGCCACA CGCCGCCCCT CTACCGCATG CGAATCTTTG CGCCTAATCA TGTCGTCGCC 
AAGTCCCGCT TCTGGTACTT TGTATCTCAG TTAAAGAAGA TGAAGAAGTC TTCAGGGGAG 
ATTGTCTACT GTGGGCAGGT GTTTGAGAAG TCCCCCCTGC GGGTGAAGAA CTTCGGGATC 
TGGCTGCGCT ATGACTCCCG GAGCGGCACC CACAACATGT ACCGGGAATA CCGGGACCTG 
ACCACCGCAG GCGCTGTCAC CCAGTGCTAC CGAGACATGG GTGCCCGGCA CCGCGCCCGA 
GCCCACTCCA TTCAGATCAT GAAGGTGGAG GAGATCGCGG CCAGCAAGTG CCGCCGGCCG 
GCTGTCAAGC AGTTCCACGA CTCCAAGATC AAGTTCCCGC TGCCCCACCG GGTCCTGCGC 
CGTCAGCACA AGCCACGCTT CACCACCAAG AGGCCCAACA CCTTCTTCTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Architecture of the human interactome defines protein communities and disease networks.
Nature545(7655)505-509(2017 05)
Huttlin EL,Bruckner RJ,Paulo JA,Cannon JR,Ting L,Baltier K,Colby G,Gebreab F,Gygi MP,Parzen H,Szpyt J,Tam S,Zarraga G,Pontano-Vaites L,Swarup S,White AE,Schweppe DK,Rad R,Erickson BK,Obar RA,Guruharsha KG,Li K,Artavanis-Tsakonas S,Gygi SP,Harper JW

Structural snapshots of actively translating human ribosomes.
Cell161(4)845-57(2015 May)
Behrmann E,Loerke J,Budkevich TV,Yamamoto K,Schmidt A,Penczek PA,Vos MR,B?rger J,Mielke T,Scheerer P,Spahn CM

Host factors that interact with the pestivirus N-terminal protease, Npro, are components of the ribonucleoprotein complex.
Journal of virology88(18)10340-53(2014 Sep)
Jefferson M,Donaszi-Ivanov A,Pollen S,Dalmay T,Saalbach G,Powell PP

The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.
Molecular cell46(5)674-90(2012 Jun)
Baltz AG,Munschauer M,Schwanh?usser B,Vasile A,Murakawa Y,Schueler M,Youngs N,Penfold-Brown D,Drew K,Milek M,Wyler E,Bonneau R,Selbach M,Dieterich C,Landthaler M

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RPL18A cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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