PXMP2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	PXMP2
Entrez Gene ID	5827
Full Name	peroxisomal membrane protein 2
Synonyms	PMP22
General protein information	Preferred Names peroxisomal membrane protein 2 Names peroxisomal membrane protein 2 22 kDa peroxisomal membrane protein peroxisomal membrane protein 2, 22kDa
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 12 Map Location: 12q24.33
Disorder MIM:	617399

mRNA and Protein(s)

mRNA	Protein	Name
NM_018663.3	NP_061133.1	peroxisomal membrane protein 2
NM_018663.2	NP_061133.1	peroxisomal membrane protein 2

Pathways from BioSystems

Homologies

Bos taurus (cattle)	PXMP2	NP_001039473.1
Xenopus tropicalis (tropical clawed frog)	pxmp2	NP_001006885.1
	PXMP2	XP_001083110.1
Rattus norvegicus (Norway rat)	Pxmp2	NP_113775.1
Arabidopsis thaliana (thale cress)	AT5G19750	NP_197476.1
Homo sapiens (human)	PXMP2	NP_061133.1
Canis lupus familiaris (dog)	PXMP2	XP_005636557.1
Danio rerio (zebrafish)	pxmp2	NP_001004607.1
Mus musculus (house mouse)	Pxmp2	NP_033019.2

Gene Ontology
Bibliography

Related articles in PubMed

Architecture of the human interactome defines protein communities and disease networks.
Huttlin EL, Bruckner RJ, Paulo JA, Cannon JR, Ting L, Baltier K, Colby G, Gebreab F, Gygi MP, Parzen H, Szpyt J, Tam S, Zarraga G, Pontano-Vaites L, Swarup S, White AE, Schweppe DK, Rad R, Erickson BK, Obar RA, Guruharsha KG, Li K, Artavanis-Tsakonas S, Gygi SP, Harper JW
Nature545(7655)505-509(2017 05)

Structural basis for docking of peroxisomal membrane protein carrier Pex19p onto its receptor Pex3p.
Sato Y, Shibata H, Nakatsu T, Nakano H, Kashiwayama Y, Imanaka T, Kato H
The EMBO journal29(24)4083-93(2010 Dec)

Defining the membrane proteome of NK cells.
Ghosh D, Lippert D, Krokhin O, Cortens JP, Wilkins JA
Journal of mass spectrometry : JMS45(1)1-25(2010 Jan)

Pxmp2 is a channel-forming protein in Mammalian peroxisomal membrane.
Rokka A, Antonenkov VD, Soininen R, Immonen HL, Piril? PL, Bergmann U, Sormunen RT, Weckstr?m M, Benz R, Hiltunen JK
PloS one4(4)e5090(2009)

Characterization of the interaction between recombinant human peroxin Pex3p and Pex19p: identification of TRP-104 IN Pex3p as a critical residue for the interaction.
Sato Y, Shibata H, Nakano H, Matsuzono Y, Kashiwayama Y, Kobayashi Y, Fujiki Y, Imanaka T, Kato H
The Journal of biological chemistry283(10)6136-44(2008 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following PXMP2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PXMP2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu00667	NM_018663.3 Latest version!	Homo sapiens peroxisomal membrane protein 2 (PXMP2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu00667	NM_018663.2	Homo sapiens peroxisomal membrane protein 2 (PXMP2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

PXMP2 ( NM_018663.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_061133.1 Homo sapiens peroxisomal membrane protein 2 (PXMP2), mRNA.

Price & Availability↑

CloneID	OHu00667
Clone ID Related Accession (Same CDS sequence)	NM_018663.3 , NM_018663.2
Accession Version	NM_018663.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 588bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-31
Organism	Homo sapiens(human)
Product	peroxisomal membrane protein 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC135586.8, AF250136.1 and BC073997.1. On Nov 23, 2018 this sequence version replaced NM_018663.2. ##Evidence-Data-START## Transcript exon combination :: SRR1163658.498838.1, SRR1163657.33268.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000317479.8/ ENSP00000321271.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCGCCGG CCGCGTCCAG GCTGCGGGCC GAAGCCGGGC TCGGGGCGCT GCCGCGGCGG 
GCGCTCGCCC AGTACCTGCT CTTCCTGCGG CTCTACCCGG TGCTCACCAA GGCGGCCACC 
AGTGGCATTT TGTCAGCACT TGGGAACTTC CTGGCCCAGA TGATTGAGAA GAAGCGGAAA 
AAAGAAAACT CTAGAAGTCT GGATGTCGGT GGGCCTCTGA GATATGCCGT TTACGGGTTC 
TTCTTCACAG GGCCGCTGAG TCACTTCTTC TACTTCTTCA TGGAACATTG GATCCCTCCT 
GAGGTCCCCC TGGCAGGGCT CAGGAGGCTT CTCCTGGACC GCCTCGTCTT TGCACCGGCC 
TTCCTCATGT TGTTCTTCCT CATCATGAAC TTTCTGGAGG GGAAAGACGC CTCAGCCTTC 
GCCGCCAAGA TGAGGGGGGG CTTCTGGCCG GCGCTGAGGA TGAACTGGCG GGTGTGGACG 
CCACTACAGT TCATCAACAT CAACTACGTC CCTCTGAAGT TCCGGGTGCT CTTCGCCAAC 
CTGGCAGCTC TGTTCTGGTA TGCCTACCTG GCCTCCTTGG GGAAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_061133.1
CDS	85..672
Translation	MAPAASRLRAEAGLGALPRRALAQYLLFLRLYPVLTKAATSGILSALGNFLAQMIEKKRKKENSRSLDVGGPLRYAVYGFFFTGPLSHFFYFFMEHWIPPEVPLAGLRRLLLDRLVFAPAFLMLFFLIMNFLEGKDASAFAAKMRGGFWPALRMNWRVWTPLQFININYVPLKFRVLFANLAALFWYAYLASLGK

Target ORF information:

RefSeq Version	NM_018663.3
Organism	Homo sapiens(human)
Definition	Homo sapiens peroxisomal membrane protein 2 (PXMP2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_018663.3

ORF Insert Sequence:

ATGGCGCCGG CCGCGTCCAG GCTGCGGGCC GAAGCCGGGC TCGGGGCGCT GCCGCGGCGG 
GCGCTCGCCC AGTACCTGCT CTTCCTGCGG CTCTACCCGG TGCTCACCAA GGCGGCCACC 
AGTGGCATTT TGTCAGCACT TGGGAACTTC CTGGCCCAGA TGATTGAGAA GAAGCGGAAA 
AAAGAAAACT CTAGAAGTCT GGATGTCGGT GGGCCTCTGA GATATGCCGT TTACGGGTTC 
TTCTTCACAG GGCCGCTGAG TCACTTCTTC TACTTCTTCA TGGAACATTG GATCCCTCCT 
GAGGTCCCCC TGGCAGGGCT CAGGAGGCTT CTCCTGGACC GCCTCGTCTT TGCACCGGCC 
TTCCTCATGT TGTTCTTCCT CATCATGAAC TTTCTGGAGG GGAAAGACGC CTCAGCCTTC 
GCCGCCAAGA TGAGGGGGGG CTTCTGGCCG GCGCTGAGGA TGAACTGGCG GGTGTGGACG 
CCACTACAGT TCATCAACAT CAACTACGTC CCTCTGAAGT TCCGGGTGCT CTTCGCCAAC 
CTGGCAGCTC TGTTCTGGTA TGCCTACCTG GCCTCCTTGG GGAAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PXMP2 ( NM_018663.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_061133.1 Homo sapiens peroxisomal membrane protein 2 (PXMP2), mRNA.

Price & Availability↑

CloneID	OHu00667
Clone ID Related Accession (Same CDS sequence)	NM_018663.3 , NM_018663.2
Accession Version	NM_018663.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 588bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-02
Organism	Homo sapiens(human)
Product	peroxisomal membrane protein 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AF250136.1 and BC073997.1. On Sep 27, 2013 this sequence version replaced NM_018663.1. ##Evidence-Data-START## Transcript exon combination :: AF250136.1, SRR1163657.195310.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END##

ATGGCGCCGG CCGCGTCCAG GCTGCGGGCC GAAGCCGGGC TCGGGGCGCT GCCGCGGCGG 
GCGCTCGCCC AGTACCTGCT CTTCCTGCGG CTCTACCCGG TGCTCACCAA GGCGGCCACC 
AGTGGCATTT TGTCAGCACT TGGGAACTTC CTGGCCCAGA TGATTGAGAA GAAGCGGAAA 
AAAGAAAACT CTAGAAGTCT GGATGTCGGT GGGCCTCTGA GATATGCCGT TTACGGGTTC 
TTCTTCACAG GGCCGCTGAG TCACTTCTTC TACTTCTTCA TGGAACATTG GATCCCTCCT 
GAGGTCCCCC TGGCAGGGCT CAGGAGGCTT CTCCTGGACC GCCTCGTCTT TGCACCGGCC 
TTCCTCATGT TGTTCTTCCT CATCATGAAC TTTCTGGAGG GGAAAGACGC CTCAGCCTTC 
GCCGCCAAGA TGAGGGGGGG CTTCTGGCCG GCGCTGAGGA TGAACTGGCG GGTGTGGACG 
CCACTACAGT TCATCAACAT CAACTACGTC CCTCTGAAGT TCCGGGTGCT CTTCGCCAAC 
CTGGCAGCTC TGTTCTGGTA TGCCTACCTG GCCTCCTTGG GGAAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_061133.1
CDS	66..653
Translation	MAPAASRLRAEAGLGALPRRALAQYLLFLRLYPVLTKAATSGILSALGNFLAQMIEKKRKKENSRSLDVGGPLRYAVYGFFFTGPLSHFFYFFMEHWIPPEVPLAGLRRLLLDRLVFAPAFLMLFFLIMNFLEGKDASAFAAKMRGGFWPALRMNWRVWTPLQFININYVPLKFRVLFANLAALFWYAYLASLGK

Target ORF information:

RefSeq Version	NM_018663.2
Organism	Homo sapiens(human)
Definition	Homo sapiens peroxisomal membrane protein 2 (PXMP2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_018663.2

ORF Insert Sequence:

ATGGCGCCGG CCGCGTCCAG GCTGCGGGCC GAAGCCGGGC TCGGGGCGCT GCCGCGGCGG 
GCGCTCGCCC AGTACCTGCT CTTCCTGCGG CTCTACCCGG TGCTCACCAA GGCGGCCACC 
AGTGGCATTT TGTCAGCACT TGGGAACTTC CTGGCCCAGA TGATTGAGAA GAAGCGGAAA 
AAAGAAAACT CTAGAAGTCT GGATGTCGGT GGGCCTCTGA GATATGCCGT TTACGGGTTC 
TTCTTCACAG GGCCGCTGAG TCACTTCTTC TACTTCTTCA TGGAACATTG GATCCCTCCT 
GAGGTCCCCC TGGCAGGGCT CAGGAGGCTT CTCCTGGACC GCCTCGTCTT TGCACCGGCC 
TTCCTCATGT TGTTCTTCCT CATCATGAAC TTTCTGGAGG GGAAAGACGC CTCAGCCTTC 
GCCGCCAAGA TGAGGGGGGG CTTCTGGCCG GCGCTGAGGA TGAACTGGCG GGTGTGGACG 
CCACTACAGT TCATCAACAT CAACTACGTC CCTCTGAAGT TCCGGGTGCT CTTCGCCAAC 
CTGGCAGCTC TGTTCTGGTA TGCCTACCTG GCCTCCTTGG GGAAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Architecture of the human interactome defines protein communities and disease networks.
Nature545(7655)505-509(2017 05)
Huttlin EL,Bruckner RJ,Paulo JA,Cannon JR,Ting L,Baltier K,Colby G,Gebreab F,Gygi MP,Parzen H,Szpyt J,Tam S,Zarraga G,Pontano-Vaites L,Swarup S,White AE,Schweppe DK,Rad R,Erickson BK,Obar RA,Guruharsha KG,Li K,Artavanis-Tsakonas S,Gygi SP,Harper JW

Structural basis for docking of peroxisomal membrane protein carrier Pex19p onto its receptor Pex3p.
The EMBO journal29(24)4083-93(2010 Dec)
Sato Y,Shibata H,Nakatsu T,Nakano H,Kashiwayama Y,Imanaka T,Kato H

Defining the membrane proteome of NK cells.
Journal of mass spectrometry : JMS45(1)1-25(2010 Jan)
Ghosh D,Lippert D,Krokhin O,Cortens JP,Wilkins JA

Pxmp2 is a channel-forming protein in Mammalian peroxisomal membrane.
PloS one4(4)e5090(2009)
Rokka A,Antonenkov VD,Soininen R,Immonen HL,Piril? PL,Bergmann U,Sormunen RT,Weckstr?m M,Benz R,Hiltunen JK

Characterization of the interaction between recombinant human peroxin Pex3p and Pex19p: identification of TRP-104 IN Pex3p as a critical residue for the interaction.
The Journal of biological chemistry283(10)6136-44(2008 Mar)
Sato Y,Shibata H,Nakano H,Matsuzono Y,Kashiwayama Y,Kobayashi Y,Fujiki Y,Imanaka T,Kato H