XAB2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	XAB2
Entrez Gene ID	56949
Full Name	XPA binding protein 2
Synonyms	HCNP,HCRN,NTC90,SYF1
General protein information	Preferred Names XPA binding protein 2 Names pre-mRNA-splicing factor SYF1 SYF1 homolog, RNA splicing factor SYF1 pre-mRNA-splicing factor crn-related protein kim1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 19 Map Location: 19p13.2
Disorder MIM:	610850

mRNA and Protein(s)

mRNA	Protein	Name
NM_020196.3	NP_064581.2	pre-mRNA-splicing factor SYF1
NM_020196.2	NP_064581.2	pre-mRNA-splicing factor SYF1

Pathways from BioSystems

Homologies

Drosophila melanogaster (fruit fly)	CG6197	NP_610891.1
Oryza sativa (rice)	Os07g0644300	NP_001060448.1
Xenopus tropicalis (tropical clawed frog)	xab2	NP_001135604.1
Bos taurus (cattle)	XAB2	NP_001069387.1
Schizosaccharomyces pombe (fission yeast)	cwf3	NP_596612.1
Magnaporthe oryzae (rice blast fungus)	MGG_07087	XP_003715277.1
Neurospora crassa	NCU08036	XP_962706.1
Homo sapiens (human)	XAB2	NP_064581.2
Canis lupus familiaris (dog)	XAB2	XP_542113.3
Rattus norvegicus (Norway rat)	Xab2	NP_620809.1
Arabidopsis thaliana (thale cress)	AT5G28740	NP_198226.1
Pan troglodytes (chimpanzee)	XAB2	XP_003316095.2
Danio rerio (zebrafish)	xab2	NP_001038248.1
	XAB2	XP_001090436.2
Mus musculus (house mouse)	Xab2	NP_080432.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP012369	XP_320187.4
Caenorhabditis elegans (roundworm)	C50F2.3	NP_491250.1

Gene Ontology
Bibliography

Related articles in PubMed

Architecture of the human interactome defines protein communities and disease networks.
Huttlin EL, Bruckner RJ, Paulo JA, Cannon JR, Ting L, Baltier K, Colby G, Gebreab F, Gygi MP, Parzen H, Szpyt J, Tam S, Zarraga G, Pontano-Vaites L, Swarup S, White AE, Schweppe DK, Rad R, Erickson BK, Obar RA, Guruharsha KG, Li K, Artavanis-Tsakonas S, Gygi SP, Harper JW
Nature545(7655)505-509(2017 05)

Cryo-EM structure of a human spliceosome activated for step 2 of splicing.
Bertram K, Agafonov DE, Liu WT, Dybkov O, Will CL, Hartmuth K, Urlaub H, Kastner B, Stark H, L?hrmann R
Nature542(7641)318-323(2017 02)

XAB2 functions in mitotic cell cycle progression via transcriptional regulation of CENPE.
Hou S, Li N, Zhang Q, Li H, Wei X, Hao T, Li Y, Azam S, Liu C, Cheng W, Jin B, Liu Q, Li M, Lei H
Cell death & disease7(10)e2409(2016 Oct)

Tetratricopeptide repeat factor XAB2 mediates the end resection step of homologous recombination.
Onyango DO, Howard SM, Neherin K, Yanez DA, Stark JM
Nucleic acids research44(12)5702-16(2016 07)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

these results support a novel function of XAB2 in mitotic cell cycle regulation, which is partially mediated by transcription regulation on CENPE.
Title: XAB2 functions in mitotic cell cycle progression via transcriptional regulation of CENPE.

we suggest that the XAB2 complex mediates DNA damage response events important for the end resection step of homologous recombination , and speculate that its adjacent-localization relative to double-strand break marked by gH2AX is important for this function
Title: Tetratricopeptide repeat factor XAB2 mediates the end resection step of homologous recombination.

Study identifies XAB2 tagSNPs (rs794078 and rs4134816) significantly associated with the risk of non-small cell lung cancer (NSCLC) in Chinese population, which supports XAB2 playing significant role in the development of NSCLC.
Title: XAB2 tagSNPs contribute to non-small cell lung cancer susceptibility in Chinese population.

Results of protein-protein interaction between human Dbr1 and factors found in the Intron Large complex identify Xab2 and a novel protein CWF19L1 as specific interactors of DBR1.
Title: Identification of the specific interactors of the human lariat RNA debranching enzyme 1 protein.

Hematopoietic myeloid cell differentiation diminishes nucleotide excision repair and XAB2 expression.
Title: Hematopoietic myeloid cell differentiation diminishes nucleotide excision repair.

The following XAB2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the XAB2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu03244	NM_020196.3 Latest version!	Homo sapiens XPA binding protein 2 (XAB2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$429.50-$601.30 $859.00
View Old Accession Versions >>
OHu03244	NM_020196.2	Homo sapiens XPA binding protein 2 (XAB2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$429.50-$601.30 $859.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

XAB2 ( NM_020196.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_064581.2 Homo sapiens XPA binding protein 2 (XAB2), mRNA.

Price & Availability↑

CloneID	OHu03244
Clone ID Related Accession (Same CDS sequence)	NM_020196.3 , NM_020196.2
Accession Version	NM_020196.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2568bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-15
Organism	Homo sapiens(human)
Product	pre-mRNA-splicing factor SYF1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AF226051.1 and BC007208.1. On Nov 22, 2018 this sequence version replaced NM_020196.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF226051.1, AF272147.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000358368.5/ ENSP00000351137.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGTGGTGA TGGCGCGACT CTCGCGGCCC GAGCGGCCGG ACCTTGTCTT CGAGGAAGAG 
GACCTCCCCT ATGAGGAGGA AATCATGCGG AACCAATTCT CTGTCAAATG CTGGCTTCGC 
TACATCGAGT TCAAACAGGG CGCCCCGAAG CCCAGGCTCA ATCAGCTATA CGAGCGGGCA 
CTCAAGCTGC TGCCCTGCAG CTACAAACTC TGGTACCGAT ACCTGAAGGC GCGTCGGGCA 
CAGGTGAAGC ATCGCTGTGT GACCGACCCT GCCTATGAAG ATGTCAACAA CTGTCATGAG 
AGGGCCTTTG TGTTCATGCA CAAGATGCCT CGTCTGTGGC TAGATTACTG CCAGTTCCTC 
ATGGACCAGG GGCGCGTCAC ACACACCCGC CGCACCTTCG ACCGTGCCCT CCGGGCACTG 
CCCATCACGC AGCACTCTCG AATTTGGCCC CTGTATCTGC GCTTCCTGCG CTCACACCCA 
CTGCCTGAGA CAGCTGTGCG AGGCTATCGG CGCTTCCTCA AGCTGAGTCC TGAGAGTGCA 
GAGGAGTACA TTGAGTACCT CAAGTCAAGT GACCGGCTGG ATGAGGCCGC CCAGCGCCTG 
GCCACCGTGG TGAACGACGA GCGTTTCGTG TCTAAGGCCG GCAAGTCCAA CTACCAGCTG 
TGGCACGAGC TGTGCGACCT CATCTCCCAG AATCCGGACA AGGTACAGTC CCTCAATGTG 
GACGCCATCA TCCGCGGGGG CCTCACCCGC TTCACCGACC AGCTGGGCAA GCTCTGGTGT 
TCTCTCGCCG ACTACTACAT CCGCAGCGGC CATTTCGAGA AGGCTCGGGA CGTGTACGAG 
GAGGCCATCC GGACAGTGAT GACCGTGCGG GACTTCACAC AGGTGTTTGA CAGCTACGCC 
CAGTTCGAGG AGAGCATGAT CGCTGCAAAG ATGGAGACCG CCTCGGAGCT GGGGCGCGAG 
GAGGAGGATG ATGTGGACCT GGAGCTGCGC CTGGCCCGCT TCGAGCAGCT CATCAGCCGG 
CGGCCCCTGC TCCTCAACAG CGTCTTGCTG CGCCAAAACC CACACCACGT GCACGAGTGG 
CACAAGCGTG TCGCCCTGCA CCAGGGCCGC CCCCGGGAGA TCATCAACAC CTACACAGAG 
GCTGTGCAGA CGGTGGACCC CTTCAAGGCC ACAGGCAAGC CCCACACTCT GTGGGTGGCG 
TTTGCCAAGT TTTATGAGGA CAACGGACAG CTGGACGATG CCCGTGTCAT CCTGGAGAAG 
GCCACCAAGG TGAACTTCAA GCAGGTGGAT GACCTGGCAA GCGTGTGGTG TCAGTGCGGA 
GAGCTGGAGC TCCGACACGA GAACTACGAT GAGGCCTTGC GGCTGCTGCG AAAGGCCACG 
GCGCTGCCTG CCCGCCGGGC CGAGTACTTT GATGGTTCAG AGCCCGTGCA GAACCGCGTG 
TACAAGTCAC TGAAGGTCTG GTCCATGCTC GCCGACCTGG AGGAGAGCCT CGGCACCTTC 
CAGTCCACCA AGGCCGTGTA CGACCGCATC CTGGACCTGC GTATCGCAAC ACCCCAGATC 
GTCATCAACT ATGCCATGTT CCTGGAGGAG CACAAGTACT TCGAGGAGAG CTTCAAGGCG 
TACGAGCGCG GCATCTCGCT GTTCAAGTGG CCCAACGTGT CCGACATCTG GAGCACCTAC 
CTGACCAAAT TCATTGCCCG CTATGGGGGC CGCAAGCTGG AGCGGGCACG GGACCTGTTT 
GAACAGGCTC TGGACGGCTG CCCCCCAAAA TATGCCAAGA CCTTGTACCT GCTGTACGCA 
CAGCTGGAGG AGGAGTGGGG CCTGGCCCGG CATGCCATGG CCGTGTACGA GCGTGCCACC 
AGGGCCGTGG AGCCCGCCCA GCAGTATGAC ATGTTCAACA TCTACATCAA GCGGGCGGCC 
GAGATCTATG GGGTCACCCA CACCCGCGGC ATCTACCAGA AGGCCATTGA GGTGCTGTCG 
GACGAGCACG CGCGTGAGAT GTGCCTGCGG TTTGCAGACA TGGAGTGCAA GCTCGGGGAG 
ATTGACCGCG CCCGGGCCAT CTACAGCTTC TGCTCCCAGA TCTGTGACCC CCGGACGACC 
GGCGCGTTCT GGCAGACGTG GAAGGACTTT GAGGTCCGGC ATGGCAATGA GGACACCATC 
AAGGAAATGC TGCGTATCCG GCGCAGCGTG CAGGCCACGT ACAACACGCA GGTCAACTTC 
ATGGCCTCGC AGATGCTCAA GGTCTCGGGC AGTGCCACGG GCACCGTGTC TGACCTGGCC 
CCTGGGCAGA GTGGCATGGA CGACATGAAG CTGCTGGAAC AGCGGGCAGA GCAGCTGGCG 
GCTGAGGCGG AGCGTGACCA GCCCTTGCGC GCCCAGAGCA AGATCCTGTT CGTGAGGAGT 
GACGCCTCCC GGGAGGAGCT GGCAGAGCTG GCACAGCAGG TCAACCCCGA GGAGATCCAG 
CTGGGCGAGG ACGAGGACGA GGACGAGATG GACCTGGAGC CCAACGAGGT TCGGCTGGAG 
CAGCAGAGCG TGCCAGCCGC AGTGTTTGGG AGCCTGAAGG AAGACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_064581.2
CDS	19..2586
Translation	MVVMARLSRPERPDLVFEEEDLPYEEEIMRNQFSVKCWLRYIEFKQGAPKPRLNQLYERALKLLPCSYKLWYRYLKARRAQVKHRCVTDPAYEDVNNCHERAFVFMHKMPRLWLDYCQFLMDQGRVTHTRRTFDRALRALPITQHSRIWPLYLRFLRSHPLPETAVRGYRRFLKLSPESAEEYIEYLKSSDRLDEAAQRLATVVNDERFVSKAGKSNYQLWHELCDLISQNPDKVQSLNVDAIIRGGLTRFTDQLGKLWCSLADYYIRSGHFEKARDVYEEAIRTVMTVRDFTQVFDSYAQFEESMIAAKMETASELGREEEDDVDLELRLARFEQLISRRPLLLNSVLLRQNPHHVHEWHKRVALHQGRPREIINTYTEAVQTVDPFKATGKPHTLWVAFAKFYEDNGQLDDARVILEKATKVNFKQVDDLASVWCQCGELELRHENYDEALRLLRKATALPARRAEYFDGSEPVQNRVYKSLKVWSMLADLEESLGTFQSTKAVYDRILDLRIATPQIVINYAMFLEEHKYFEESFKAYERGISLFKWPNVSDIWSTYLTKFIARYGGRKLERARDLFEQALDGCPPKYAKTLYLLYAQLEEEWGLARHAMAVYERATRAVEPAQQYDMFNIYIKRAAEIYGVTHTRGIYQKAIEVLSDEHAREMCLRFADMECKLGEIDRARAIYSFCSQICDPRTTGAFWQTWKDFEVRHGNEDTIKEMLRIRRSVQATYNTQVNFMASQMLKVSGSATGTVSDLAPGQSGMDDMKLLEQRAEQLAAEAERDQPLRAQSKILFVRSDASREELAELAQQVNPEEIQLGEDEDEDEMDLEPNEVRLEQQSVPAAVFGSLKED

Target ORF information:

RefSeq Version	NM_020196.3
Organism	Homo sapiens(human)
Definition	Homo sapiens XPA binding protein 2 (XAB2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_020196.3

ORF Insert Sequence:

ATGGTGGTGA TGGCGCGACT CTCGCGGCCC GAGCGGCCGG ACCTTGTCTT CGAGGAAGAG 
GACCTCCCCT ATGAGGAGGA AATCATGCGG AACCAATTCT CTGTCAAATG CTGGCTTCGC 
TACATCGAGT TCAAACAGGG CGCCCCGAAG CCCAGGCTCA ATCAGCTATA CGAGCGGGCA 
CTCAAGCTGC TGCCCTGCAG CTACAAACTC TGGTACCGAT ACCTGAAGGC GCGTCGGGCA 
CAGGTGAAGC ATCGCTGTGT GACCGACCCT GCCTATGAAG ATGTCAACAA CTGTCATGAG 
AGGGCCTTTG TGTTCATGCA CAAGATGCCT CGTCTGTGGC TAGATTACTG CCAGTTCCTC 
ATGGACCAGG GGCGCGTCAC ACACACCCGC CGCACCTTCG ACCGTGCCCT CCGGGCACTG 
CCCATCACGC AGCACTCTCG AATTTGGCCC CTGTATCTGC GCTTCCTGCG CTCACACCCA 
CTGCCTGAGA CAGCTGTGCG AGGCTATCGG CGCTTCCTCA AGCTGAGTCC TGAGAGTGCA 
GAGGAGTACA TTGAGTACCT CAAGTCAAGT GACCGGCTGG ATGAGGCCGC CCAGCGCCTG 
GCCACCGTGG TGAACGACGA GCGTTTCGTG TCTAAGGCCG GCAAGTCCAA CTACCAGCTG 
TGGCACGAGC TGTGCGACCT CATCTCCCAG AATCCGGACA AGGTACAGTC CCTCAATGTG 
GACGCCATCA TCCGCGGGGG CCTCACCCGC TTCACCGACC AGCTGGGCAA GCTCTGGTGT 
TCTCTCGCCG ACTACTACAT CCGCAGCGGC CATTTCGAGA AGGCTCGGGA CGTGTACGAG 
GAGGCCATCC GGACAGTGAT GACCGTGCGG GACTTCACAC AGGTGTTTGA CAGCTACGCC 
CAGTTCGAGG AGAGCATGAT CGCTGCAAAG ATGGAGACCG CCTCGGAGCT GGGGCGCGAG 
GAGGAGGATG ATGTGGACCT GGAGCTGCGC CTGGCCCGCT TCGAGCAGCT CATCAGCCGG 
CGGCCCCTGC TCCTCAACAG CGTCTTGCTG CGCCAAAACC CACACCACGT GCACGAGTGG 
CACAAGCGTG TCGCCCTGCA CCAGGGCCGC CCCCGGGAGA TCATCAACAC CTACACAGAG 
GCTGTGCAGA CGGTGGACCC CTTCAAGGCC ACAGGCAAGC CCCACACTCT GTGGGTGGCG 
TTTGCCAAGT TTTATGAGGA CAACGGACAG CTGGACGATG CCCGTGTCAT CCTGGAGAAG 
GCCACCAAGG TGAACTTCAA GCAGGTGGAT GACCTGGCAA GCGTGTGGTG TCAGTGCGGA 
GAGCTGGAGC TCCGACACGA GAACTACGAT GAGGCCTTGC GGCTGCTGCG AAAGGCCACG 
GCGCTGCCTG CCCGCCGGGC CGAGTACTTT GATGGTTCAG AGCCCGTGCA GAACCGCGTG 
TACAAGTCAC TGAAGGTCTG GTCCATGCTC GCCGACCTGG AGGAGAGCCT CGGCACCTTC 
CAGTCCACCA AGGCCGTGTA CGACCGCATC CTGGACCTGC GTATCGCAAC ACCCCAGATC 
GTCATCAACT ATGCCATGTT CCTGGAGGAG CACAAGTACT TCGAGGAGAG CTTCAAGGCG 
TACGAGCGCG GCATCTCGCT GTTCAAGTGG CCCAACGTGT CCGACATCTG GAGCACCTAC 
CTGACCAAAT TCATTGCCCG CTATGGGGGC CGCAAGCTGG AGCGGGCACG GGACCTGTTT 
GAACAGGCTC TGGACGGCTG CCCCCCAAAA TATGCCAAGA CCTTGTACCT GCTGTACGCA 
CAGCTGGAGG AGGAGTGGGG CCTGGCCCGG CATGCCATGG CCGTGTACGA GCGTGCCACC 
AGGGCCGTGG AGCCCGCCCA GCAGTATGAC ATGTTCAACA TCTACATCAA GCGGGCGGCC 
GAGATCTATG GGGTCACCCA CACCCGCGGC ATCTACCAGA AGGCCATTGA GGTGCTGTCG 
GACGAGCACG CGCGTGAGAT GTGCCTGCGG TTTGCAGACA TGGAGTGCAA GCTCGGGGAG 
ATTGACCGCG CCCGGGCCAT CTACAGCTTC TGCTCCCAGA TCTGTGACCC CCGGACGACC 
GGCGCGTTCT GGCAGACGTG GAAGGACTTT GAGGTCCGGC ATGGCAATGA GGACACCATC 
AAGGAAATGC TGCGTATCCG GCGCAGCGTG CAGGCCACGT ACAACACGCA GGTCAACTTC 
ATGGCCTCGC AGATGCTCAA GGTCTCGGGC AGTGCCACGG GCACCGTGTC TGACCTGGCC 
CCTGGGCAGA GTGGCATGGA CGACATGAAG CTGCTGGAAC AGCGGGCAGA GCAGCTGGCG 
GCTGAGGCGG AGCGTGACCA GCCCTTGCGC GCCCAGAGCA AGATCCTGTT CGTGAGGAGT 
GACGCCTCCC GGGAGGAGCT GGCAGAGCTG GCACAGCAGG TCAACCCCGA GGAGATCCAG 
CTGGGCGAGG ACGAGGACGA GGACGAGATG GACCTGGAGC CCAACGAGGT TCGGCTGGAG 
CAGCAGAGCG TGCCAGCCGC AGTGTTTGGG AGCCTGAAGG AAGACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

XAB2 ( NM_020196.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_064581.2 Homo sapiens XPA binding protein 2 (XAB2), mRNA.

Price & Availability↑

CloneID	OHu03244
Clone ID Related Accession (Same CDS sequence)	NM_020196.3 , NM_020196.2
Accession Version	NM_020196.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2568bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-30
Organism	Homo sapiens(human)
Product	pre-mRNA-splicing factor SYF1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AF226051.1 and BC007208.1. On Nov 15, 2004 this sequence version replaced NM_020196.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF226051.1, AF272147.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGTGGTGA TGGCGCGACT CTCGCGGCCC GAGCGGCCGG ACCTTGTCTT CGAGGAAGAG 
GACCTCCCCT ATGAGGAGGA AATCATGCGG AACCAATTCT CTGTCAAATG CTGGCTTCGC 
TACATCGAGT TCAAACAGGG CGCCCCGAAG CCCAGGCTCA ATCAGCTATA CGAGCGGGCA 
CTCAAGCTGC TGCCCTGCAG CTACAAACTC TGGTACCGAT ACCTGAAGGC GCGTCGGGCA 
CAGGTGAAGC ATCGCTGTGT GACCGACCCT GCCTATGAAG ATGTCAACAA CTGTCATGAG 
AGGGCCTTTG TGTTCATGCA CAAGATGCCT CGTCTGTGGC TAGATTACTG CCAGTTCCTC 
ATGGACCAGG GGCGCGTCAC ACACACCCGC CGCACCTTCG ACCGTGCCCT CCGGGCACTG 
CCCATCACGC AGCACTCTCG AATTTGGCCC CTGTATCTGC GCTTCCTGCG CTCACACCCA 
CTGCCTGAGA CAGCTGTGCG AGGCTATCGG CGCTTCCTCA AGCTGAGTCC TGAGAGTGCA 
GAGGAGTACA TTGAGTACCT CAAGTCAAGT GACCGGCTGG ATGAGGCCGC CCAGCGCCTG 
GCCACCGTGG TGAACGACGA GCGTTTCGTG TCTAAGGCCG GCAAGTCCAA CTACCAGCTG 
TGGCACGAGC TGTGCGACCT CATCTCCCAG AATCCGGACA AGGTACAGTC CCTCAATGTG 
GACGCCATCA TCCGCGGGGG CCTCACCCGC TTCACCGACC AGCTGGGCAA GCTCTGGTGT 
TCTCTCGCCG ACTACTACAT CCGCAGCGGC CATTTCGAGA AGGCTCGGGA CGTGTACGAG 
GAGGCCATCC GGACAGTGAT GACCGTGCGG GACTTCACAC AGGTGTTTGA CAGCTACGCC 
CAGTTCGAGG AGAGCATGAT CGCTGCAAAG ATGGAGACCG CCTCGGAGCT GGGGCGCGAG 
GAGGAGGATG ATGTGGACCT GGAGCTGCGC CTGGCCCGCT TCGAGCAGCT CATCAGCCGG 
CGGCCCCTGC TCCTCAACAG CGTCTTGCTG CGCCAAAACC CACACCACGT GCACGAGTGG 
CACAAGCGTG TCGCCCTGCA CCAGGGCCGC CCCCGGGAGA TCATCAACAC CTACACAGAG 
GCTGTGCAGA CGGTGGACCC CTTCAAGGCC ACAGGCAAGC CCCACACTCT GTGGGTGGCG 
TTTGCCAAGT TTTATGAGGA CAACGGACAG CTGGACGATG CCCGTGTCAT CCTGGAGAAG 
GCCACCAAGG TGAACTTCAA GCAGGTGGAT GACCTGGCAA GCGTGTGGTG TCAGTGCGGA 
GAGCTGGAGC TCCGACACGA GAACTACGAT GAGGCCTTGC GGCTGCTGCG AAAGGCCACG 
GCGCTGCCTG CCCGCCGGGC CGAGTACTTT GATGGTTCAG AGCCCGTGCA GAACCGCGTG 
TACAAGTCAC TGAAGGTCTG GTCCATGCTC GCCGACCTGG AGGAGAGCCT CGGCACCTTC 
CAGTCCACCA AGGCCGTGTA CGACCGCATC CTGGACCTGC GTATCGCAAC ACCCCAGATC 
GTCATCAACT ATGCCATGTT CCTGGAGGAG CACAAGTACT TCGAGGAGAG CTTCAAGGCG 
TACGAGCGCG GCATCTCGCT GTTCAAGTGG CCCAACGTGT CCGACATCTG GAGCACCTAC 
CTGACCAAAT TCATTGCCCG CTATGGGGGC CGCAAGCTGG AGCGGGCACG GGACCTGTTT 
GAACAGGCTC TGGACGGCTG CCCCCCAAAA TATGCCAAGA CCTTGTACCT GCTGTACGCA 
CAGCTGGAGG AGGAGTGGGG CCTGGCCCGG CATGCCATGG CCGTGTACGA GCGTGCCACC 
AGGGCCGTGG AGCCCGCCCA GCAGTATGAC ATGTTCAACA TCTACATCAA GCGGGCGGCC 
GAGATCTATG GGGTCACCCA CACCCGCGGC ATCTACCAGA AGGCCATTGA GGTGCTGTCG 
GACGAGCACG CGCGTGAGAT GTGCCTGCGG TTTGCAGACA TGGAGTGCAA GCTCGGGGAG 
ATTGACCGCG CCCGGGCCAT CTACAGCTTC TGCTCCCAGA TCTGTGACCC CCGGACGACC 
GGCGCGTTCT GGCAGACGTG GAAGGACTTT GAGGTCCGGC ATGGCAATGA GGACACCATC 
AAGGAAATGC TGCGTATCCG GCGCAGCGTG CAGGCCACGT ACAACACGCA GGTCAACTTC 
ATGGCCTCGC AGATGCTCAA GGTCTCGGGC AGTGCCACGG GCACCGTGTC TGACCTGGCC 
CCTGGGCAGA GTGGCATGGA CGACATGAAG CTGCTGGAAC AGCGGGCAGA GCAGCTGGCG 
GCTGAGGCGG AGCGTGACCA GCCCTTGCGC GCCCAGAGCA AGATCCTGTT CGTGAGGAGT 
GACGCCTCCC GGGAGGAGCT GGCAGAGCTG GCACAGCAGG TCAACCCCGA GGAGATCCAG 
CTGGGCGAGG ACGAGGACGA GGACGAGATG GACCTGGAGC CCAACGAGGT TCGGCTGGAG 
CAGCAGAGCG TGCCAGCCGC AGTGTTTGGG AGCCTGAAGG AAGACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_064581.2
CDS	27..2594
Translation	MVVMARLSRPERPDLVFEEEDLPYEEEIMRNQFSVKCWLRYIEFKQGAPKPRLNQLYERALKLLPCSYKLWYRYLKARRAQVKHRCVTDPAYEDVNNCHERAFVFMHKMPRLWLDYCQFLMDQGRVTHTRRTFDRALRALPITQHSRIWPLYLRFLRSHPLPETAVRGYRRFLKLSPESAEEYIEYLKSSDRLDEAAQRLATVVNDERFVSKAGKSNYQLWHELCDLISQNPDKVQSLNVDAIIRGGLTRFTDQLGKLWCSLADYYIRSGHFEKARDVYEEAIRTVMTVRDFTQVFDSYAQFEESMIAAKMETASELGREEEDDVDLELRLARFEQLISRRPLLLNSVLLRQNPHHVHEWHKRVALHQGRPREIINTYTEAVQTVDPFKATGKPHTLWVAFAKFYEDNGQLDDARVILEKATKVNFKQVDDLASVWCQCGELELRHENYDEALRLLRKATALPARRAEYFDGSEPVQNRVYKSLKVWSMLADLEESLGTFQSTKAVYDRILDLRIATPQIVINYAMFLEEHKYFEESFKAYERGISLFKWPNVSDIWSTYLTKFIARYGGRKLERARDLFEQALDGCPPKYAKTLYLLYAQLEEEWGLARHAMAVYERATRAVEPAQQYDMFNIYIKRAAEIYGVTHTRGIYQKAIEVLSDEHAREMCLRFADMECKLGEIDRARAIYSFCSQICDPRTTGAFWQTWKDFEVRHGNEDTIKEMLRIRRSVQATYNTQVNFMASQMLKVSGSATGTVSDLAPGQSGMDDMKLLEQRAEQLAAEAERDQPLRAQSKILFVRSDASREELAELAQQVNPEEIQLGEDEDEDEMDLEPNEVRLEQQSVPAAVFGSLKED

Target ORF information:

RefSeq Version	NM_020196.2
Organism	Homo sapiens(human)
Definition	Homo sapiens XPA binding protein 2 (XAB2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_020196.2

ORF Insert Sequence:

ATGGTGGTGA TGGCGCGACT CTCGCGGCCC GAGCGGCCGG ACCTTGTCTT CGAGGAAGAG 
GACCTCCCCT ATGAGGAGGA AATCATGCGG AACCAATTCT CTGTCAAATG CTGGCTTCGC 
TACATCGAGT TCAAACAGGG CGCCCCGAAG CCCAGGCTCA ATCAGCTATA CGAGCGGGCA 
CTCAAGCTGC TGCCCTGCAG CTACAAACTC TGGTACCGAT ACCTGAAGGC GCGTCGGGCA 
CAGGTGAAGC ATCGCTGTGT GACCGACCCT GCCTATGAAG ATGTCAACAA CTGTCATGAG 
AGGGCCTTTG TGTTCATGCA CAAGATGCCT CGTCTGTGGC TAGATTACTG CCAGTTCCTC 
ATGGACCAGG GGCGCGTCAC ACACACCCGC CGCACCTTCG ACCGTGCCCT CCGGGCACTG 
CCCATCACGC AGCACTCTCG AATTTGGCCC CTGTATCTGC GCTTCCTGCG CTCACACCCA 
CTGCCTGAGA CAGCTGTGCG AGGCTATCGG CGCTTCCTCA AGCTGAGTCC TGAGAGTGCA 
GAGGAGTACA TTGAGTACCT CAAGTCAAGT GACCGGCTGG ATGAGGCCGC CCAGCGCCTG 
GCCACCGTGG TGAACGACGA GCGTTTCGTG TCTAAGGCCG GCAAGTCCAA CTACCAGCTG 
TGGCACGAGC TGTGCGACCT CATCTCCCAG AATCCGGACA AGGTACAGTC CCTCAATGTG 
GACGCCATCA TCCGCGGGGG CCTCACCCGC TTCACCGACC AGCTGGGCAA GCTCTGGTGT 
TCTCTCGCCG ACTACTACAT CCGCAGCGGC CATTTCGAGA AGGCTCGGGA CGTGTACGAG 
GAGGCCATCC GGACAGTGAT GACCGTGCGG GACTTCACAC AGGTGTTTGA CAGCTACGCC 
CAGTTCGAGG AGAGCATGAT CGCTGCAAAG ATGGAGACCG CCTCGGAGCT GGGGCGCGAG 
GAGGAGGATG ATGTGGACCT GGAGCTGCGC CTGGCCCGCT TCGAGCAGCT CATCAGCCGG 
CGGCCCCTGC TCCTCAACAG CGTCTTGCTG CGCCAAAACC CACACCACGT GCACGAGTGG 
CACAAGCGTG TCGCCCTGCA CCAGGGCCGC CCCCGGGAGA TCATCAACAC CTACACAGAG 
GCTGTGCAGA CGGTGGACCC CTTCAAGGCC ACAGGCAAGC CCCACACTCT GTGGGTGGCG 
TTTGCCAAGT TTTATGAGGA CAACGGACAG CTGGACGATG CCCGTGTCAT CCTGGAGAAG 
GCCACCAAGG TGAACTTCAA GCAGGTGGAT GACCTGGCAA GCGTGTGGTG TCAGTGCGGA 
GAGCTGGAGC TCCGACACGA GAACTACGAT GAGGCCTTGC GGCTGCTGCG AAAGGCCACG 
GCGCTGCCTG CCCGCCGGGC CGAGTACTTT GATGGTTCAG AGCCCGTGCA GAACCGCGTG 
TACAAGTCAC TGAAGGTCTG GTCCATGCTC GCCGACCTGG AGGAGAGCCT CGGCACCTTC 
CAGTCCACCA AGGCCGTGTA CGACCGCATC CTGGACCTGC GTATCGCAAC ACCCCAGATC 
GTCATCAACT ATGCCATGTT CCTGGAGGAG CACAAGTACT TCGAGGAGAG CTTCAAGGCG 
TACGAGCGCG GCATCTCGCT GTTCAAGTGG CCCAACGTGT CCGACATCTG GAGCACCTAC 
CTGACCAAAT TCATTGCCCG CTATGGGGGC CGCAAGCTGG AGCGGGCACG GGACCTGTTT 
GAACAGGCTC TGGACGGCTG CCCCCCAAAA TATGCCAAGA CCTTGTACCT GCTGTACGCA 
CAGCTGGAGG AGGAGTGGGG CCTGGCCCGG CATGCCATGG CCGTGTACGA GCGTGCCACC 
AGGGCCGTGG AGCCCGCCCA GCAGTATGAC ATGTTCAACA TCTACATCAA GCGGGCGGCC 
GAGATCTATG GGGTCACCCA CACCCGCGGC ATCTACCAGA AGGCCATTGA GGTGCTGTCG 
GACGAGCACG CGCGTGAGAT GTGCCTGCGG TTTGCAGACA TGGAGTGCAA GCTCGGGGAG 
ATTGACCGCG CCCGGGCCAT CTACAGCTTC TGCTCCCAGA TCTGTGACCC CCGGACGACC 
GGCGCGTTCT GGCAGACGTG GAAGGACTTT GAGGTCCGGC ATGGCAATGA GGACACCATC 
AAGGAAATGC TGCGTATCCG GCGCAGCGTG CAGGCCACGT ACAACACGCA GGTCAACTTC 
ATGGCCTCGC AGATGCTCAA GGTCTCGGGC AGTGCCACGG GCACCGTGTC TGACCTGGCC 
CCTGGGCAGA GTGGCATGGA CGACATGAAG CTGCTGGAAC AGCGGGCAGA GCAGCTGGCG 
GCTGAGGCGG AGCGTGACCA GCCCTTGCGC GCCCAGAGCA AGATCCTGTT CGTGAGGAGT 
GACGCCTCCC GGGAGGAGCT GGCAGAGCTG GCACAGCAGG TCAACCCCGA GGAGATCCAG 
CTGGGCGAGG ACGAGGACGA GGACGAGATG GACCTGGAGC CCAACGAGGT TCGGCTGGAG 
CAGCAGAGCG TGCCAGCCGC AGTGTTTGGG AGCCTGAAGG AAGACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Architecture of the human interactome defines protein communities and disease networks.
Nature545(7655)505-509(2017 05)
Huttlin EL,Bruckner RJ,Paulo JA,Cannon JR,Ting L,Baltier K,Colby G,Gebreab F,Gygi MP,Parzen H,Szpyt J,Tam S,Zarraga G,Pontano-Vaites L,Swarup S,White AE,Schweppe DK,Rad R,Erickson BK,Obar RA,Guruharsha KG,Li K,Artavanis-Tsakonas S,Gygi SP,Harper JW

Cryo-EM structure of a human spliceosome activated for step 2 of splicing.
Nature542(7641)318-323(2017 02)
Bertram K,Agafonov DE,Liu WT,Dybkov O,Will CL,Hartmuth K,Urlaub H,Kastner B,Stark H,L?hrmann R

XAB2 functions in mitotic cell cycle progression via transcriptional regulation of CENPE.
Cell death & disease7(10)e2409(2016 Oct)
Hou S,Li N,Zhang Q,Li H,Wei X,Hao T,Li Y,Azam S,Liu C,Cheng W,Jin B,Liu Q,Li M,Lei H

Tetratricopeptide repeat factor XAB2 mediates the end resection step of homologous recombination.
Nucleic acids research44(12)5702-16(2016 07)
Onyango DO,Howard SM,Neherin K,Yanez DA,Stark JM

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XAB2 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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