CAMK2N1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	CAMK2N1
Entrez Gene ID	55450
Full Name	calcium/calmodulin dependent protein kinase II inhibitor 1
Synonyms	PRO1489
General protein information	Preferred Names calcium/calmodulin dependent protein kinase II inhibitor 1 Names calcium/calmodulin-dependent protein kinase II inhibitor 1 CaMKIINalpha caMKII inhibitory protein alpha caMKIIN-alpha
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 1 Map Location: 1p36.12
Disorder MIM:	614986

mRNA and Protein(s)

mRNA	Protein	Name
NM_018584.6	NP_061054.2	calcium/calmodulin-dependent protein kinase II inhibitor 1
NM_018584.5	NP_061054.2	calcium/calmodulin-dependent protein kinase II inhibitor 1

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	CAMK2N1	XP_001160942.1
Mus musculus (house mouse)	Camk2n1	NP_079727.1
Bos taurus (cattle)	CAMK2N1	NP_001107992.1
Rattus norvegicus (Norway rat)	Camk2n1	NP_775459.1
Homo sapiens (human)	CAMK2N1	NP_061054.2
	CAMK2N1	XP_001095951.1

Gene Ontology
Bibliography

Related articles in PubMed

Human gingiva transcriptome during wound healing.
Wang Y, Tatakis DN
Journal of clinical periodontology44(4)394-402(2017 Apr)

RUNX3 and CAMK2N1 hypermethylation as prognostic marker for epithelial ovarian cancer.
H?fner N, Steinbach D, Jansen L, Diebolder H, D?rst M, Runnebaum IB
International journal of cancer138(1)217-28(2016 Jan)

CAMK2N1 inhibits prostate cancer progression through androgen receptor-dependent signaling.
Wang T, Guo S, Liu Z, Wu L, Li M, Yang J, Chen R, Liu X, Xu H, Cai S, Chen H, Li W, Xu S, Wang L, Hu Z, Zhuang Q, Wang L, Wu K, Liu J, Ye Z, Ji JY, Wang C, Chen K
Oncotarget5(21)10293-306(2014 Nov)

The tumor suppressive role of CAMK2N1 in castration-resistant prostate cancer.
Wang T, Liu Z, Guo S, Wu L, Li M, Yang J, Chen R, Xu H, Cai S, Chen H, Li W, Wang L, Hu Z, Zhuang Q, Xu S, Wang L, Liu J, Ye Z, Ji JY, Wang C, Chen K
Oncotarget5(11)3611-21(2014 Jun)

A novel endogenous human CaMKII inhibitory protein suppresses tumor growth by inducing cell cycle arrest via p27 stabilization.
Wang C, Li N, Liu X, Zheng Y, Cao X
The Journal of biological chemistry283(17)11565-74(2008 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

CAMK2N1 expression is significantly downregulated in human masticatory mucosa during wound healing
Title: Human gingiva transcriptome during wound healing.

Hypermethylation of RUNX3/CAMK2N1 is associated with poor clinical outcome in Type II EOC, also after macroscopic complete resection.
Title: RUNX3 and CAMK2N1 hypermethylation as prognostic marker for epithelial ovarian cancer.

contributes to prostate cancer growth and survival through androgen receptor-dependent signaling
Title: CAMK2N1 inhibits prostate cancer progression through androgen receptor-dependent signaling.

Analyses suggest that CAMK2N1 plays a tumor suppressive role in prostate cancer cells. Reduced CAMK2N1 expression correlates to human prostate cancer progression and predicts poor clinical outcome.
Title: The tumor suppressive role of CAMK2N1 in castration-resistant prostate cancer.

hCaMKIINalpha suppresses tumor growth by inducing cell cycle arrest via p27 stabilization
Title: A novel endogenous human CaMKII inhibitory protein suppresses tumor growth by inducing cell cycle arrest via p27 stabilization.

The following CAMK2N1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CAMK2N1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu25982	NM_018584.6 Latest version!	Homo sapiens calcium/calmodulin dependent protein kinase II inhibitor 1 (CAMK2N1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu25982	NM_018584.5	Homo sapiens calcium/calmodulin dependent protein kinase II inhibitor 1 (CAMK2N1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CAMK2N1 ( NM_018584.6 ) cDNA ORF clone, Homo sapiens(human) -> NP_061054.2 Homo sapiens calcium/calmodulin dependent protein kinase II inhibitor 1 (CAMK2N1), mRNA.

Price & Availability↑

CloneID	OHu25982
Clone ID Related Accession (Same CDS sequence)	NM_018584.6 , NM_018584.5
Accession Version	NM_018584.6 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 237bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-26
Organism	Homo sapiens(human)
Product	calcium/calmodulin-dependent protein kinase II inhibitor 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DB475389.1, AY204901.1, AL391357.20 and BI820748.1. On Nov 23, 2018 this sequence version replaced NM_018584.5. ##Evidence-Data-START## Transcript exon combination :: SRR3476690.822171.1, ERR279868.2182.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA1968832 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000375078.4/ ENSP00000364219.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGTCGGAGG TGCTGCCCTA CGGCGACGAG AAGCTGAGCC CCTACGGCGA CGGCGGCGAC 
GTGGGCCAGA TCTTCTCCTG CCGCCTGCAG GACACCAACA ACTTCTTCGG CGCCGGGCAG 
AACAAGCGGC CGCCCAAGCT GGGCCAGATC GGCCGGAGCA AGCGGGTTGT TATTGAAGAT 
GATAGGATTG ATGACGTGCT GAAAAATATG ACCGACAAGG CACCTCCTGG TGTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_061054.2
CDS	832..1068
Translation	MSEVLPYGDEKLSPYGDGGDVGQIFSCRLQDTNNFFGAGQNKRPPKLGQIGRSKRVVIEDDRIDDVLKNMTDKAPPGV

Target ORF information:

RefSeq Version	NM_018584.6
Organism	Homo sapiens(human)
Definition	Homo sapiens calcium/calmodulin dependent protein kinase II inhibitor 1 (CAMK2N1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_018584.6

ORF Insert Sequence:

ATGTCGGAGG TGCTGCCCTA CGGCGACGAG AAGCTGAGCC CCTACGGCGA CGGCGGCGAC 
GTGGGCCAGA TCTTCTCCTG CCGCCTGCAG GACACCAACA ACTTCTTCGG CGCCGGGCAG 
AACAAGCGGC CGCCCAAGCT GGGCCAGATC GGCCGGAGCA AGCGGGTTGT TATTGAAGAT 
GATAGGATTG ATGACGTGCT GAAAAATATG ACCGACAAGG CACCTCCTGG TGTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CAMK2N1 ( NM_018584.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_061054.2 Homo sapiens calcium/calmodulin dependent protein kinase II inhibitor 1 (CAMK2N1), mRNA.

Price & Availability↑

CloneID	OHu25982
Clone ID Related Accession (Same CDS sequence)	NM_018584.6 , NM_018584.5
Accession Version	NM_018584.5	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 237bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	calcium/calmodulin-dependent protein kinase II inhibitor 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DB475389.1, AY204901.1, AL391357.20 and BI820748.1. On Sep 28, 2006 this sequence version replaced NM_018584.4. ##Evidence-Data-START## Transcript exon combination :: ERR279868.2182.1, ERR279867.2566.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA1968832 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTCGGAGG TGCTGCCCTA CGGCGACGAG AAGCTGAGCC CCTACGGCGA CGGCGGCGAC 
GTGGGCCAGA TCTTCTCCTG CCGCCTGCAG GACACCAACA ACTTCTTCGG CGCCGGGCAG 
AACAAGCGGC CGCCCAAGCT GGGCCAGATC GGCCGGAGCA AGCGGGTTGT TATTGAAGAT 
GATAGGATTG ATGACGTGCT GAAAAATATG ACCGACAAGG CACCTCCTGG TGTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_061054.2
CDS	857..1093
Translation	MSEVLPYGDEKLSPYGDGGDVGQIFSCRLQDTNNFFGAGQNKRPPKLGQIGRSKRVVIEDDRIDDVLKNMTDKAPPGV

Target ORF information:

RefSeq Version	NM_018584.5
Organism	Homo sapiens(human)
Definition	Homo sapiens calcium/calmodulin dependent protein kinase II inhibitor 1 (CAMK2N1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_018584.5

ORF Insert Sequence:

ATGTCGGAGG TGCTGCCCTA CGGCGACGAG AAGCTGAGCC CCTACGGCGA CGGCGGCGAC 
GTGGGCCAGA TCTTCTCCTG CCGCCTGCAG GACACCAACA ACTTCTTCGG CGCCGGGCAG 
AACAAGCGGC CGCCCAAGCT GGGCCAGATC GGCCGGAGCA AGCGGGTTGT TATTGAAGAT 
GATAGGATTG ATGACGTGCT GAAAAATATG ACCGACAAGG CACCTCCTGG TGTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Human gingiva transcriptome during wound healing.
Journal of clinical periodontology44(4)394-402(2017 Apr)
Wang Y,Tatakis DN

RUNX3 and CAMK2N1 hypermethylation as prognostic marker for epithelial ovarian cancer.
International journal of cancer138(1)217-28(2016 Jan)
H?fner N,Steinbach D,Jansen L,Diebolder H,D?rst M,Runnebaum IB

CAMK2N1 inhibits prostate cancer progression through androgen receptor-dependent signaling.
Oncotarget5(21)10293-306(2014 Nov)
Wang T,Guo S,Liu Z,Wu L,Li M,Yang J,Chen R,Liu X,Xu H,Cai S,Chen H,Li W,Xu S,Wang L,Hu Z,Zhuang Q,Wang L,Wu K,Liu J,Ye Z,Ji JY,Wang C,Chen K

The tumor suppressive role of CAMK2N1 in castration-resistant prostate cancer.
Oncotarget5(11)3611-21(2014 Jun)
Wang T,Liu Z,Guo S,Wu L,Li M,Yang J,Chen R,Xu H,Cai S,Chen H,Li W,Wang L,Hu Z,Zhuang Q,Xu S,Wang L,Liu J,Ye Z,Ji JY,Wang C,Chen K

A novel endogenous human CaMKII inhibitory protein suppresses tumor growth by inducing cell cycle arrest via p27 stabilization.
The Journal of biological chemistry283(17)11565-74(2008 Apr)
Wang C,Li N,Liu X,Zheng Y,Cao X