FKBP14 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	FKBP14
Entrez Gene ID	55033
Full Name	FK506 binding protein 14
Synonyms	EDSKMH,EDSKSCL2,FKBP22,IPBP12
General protein information	Preferred Names FK506 binding protein 14 Names peptidyl-prolyl cis-trans isomerase FKBP14 22 kDa FK506-binding protein 22 kDa FKBP FK506 binding protein 14, 22 kDa FKBP-22 PPIase FKBP14 rotamase
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 7 Map Location: 7p14.3
Summary	The protein encoded by this gene is a member of the FK506-binding protein family of peptidyl-prolyl cis-trans isomerases. The encoded protein is found in the lumen of the endoplasmic reticulum, where it is thought to accelerate protein folding. Defects in this gene are a cause of a type of Ehlers-Danlos syndrome (EDS). Both a protein-coding variant and noncoding variants are transcribed from this gene. [provided by RefSeq, Mar 2012].
Disorder MIM:	614505
Disorder Html:	Ehlers-Danlos syndrome with progressive kyphoscoliosis, myopathy, and hearing loss, 614557 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_017946.3	NP_060416.1	peptidyl-prolyl cis-trans isomerase FKBP14 precursor
NM_017946.4	NP_060416.1	peptidyl-prolyl cis-trans isomerase FKBP14 precursor

Pathways from BioSystems

Homologies

	FKBP14	XP_001086633.1
Canis lupus familiaris (dog)	FKBP14	XP_005628731.1
Gallus gallus (chicken)	FKBP14	XP_418735.1
Drosophila melanogaster (fruit fly)	Fkbp13	NP_001246448.1
Xenopus tropicalis (tropical clawed frog)	fkbp14	NP_001005108.1
Homo sapiens (human)	FKBP14	NP_060416.1
Danio rerio (zebrafish)	fkbp14	NP_001003471.1
Bos taurus (cattle)	FKBP14	NP_001069859.2
Rattus norvegicus (Norway rat)	Fkbp14	NP_001013228.1
Pan troglodytes (chimpanzee)	FKBP14	XP_519022.2
Mus musculus (house mouse)	Fkbp14	NP_705801.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP008822	XP_314956.4

Gene Ontology
Bibliography

Related articles in PubMed

Inhibitory effects of FKBP14 on human cervical cancer cells.
Sun LY, Tao JZ, Yan B, Lin JS
Molecular medicine reports16(4)4265-4272(2017 Oct)

Ziploc-ing the structure 2.0: Endoplasmic reticulum-resident peptidyl prolyl isomerases show different activities toward hydroxyproline.
Ishikawa Y, Mizuno K, B?chinger HP
The Journal of biological chemistry292(22)9273-9282(2017 06)

Ehlers-Danlos syndrome related to FKBP14 mutations: detailed cutaneous phenotype.
Bursztejn AC, Baumann M, Lipsker D
Clinical and experimental dermatology42(1)64-67(2017 Jan)

RNAi-Mediated Downregulation of FKBP14 Suppresses the Growth of Human Ovarian Cancer Cells.
Lu M, Miao Y, Qi L, Bai M, Zhang J, Feng Y
Oncology research23(6)267-274(2016 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

observed changes in activity of six rER-resident PPIases, cyclophilin B (encoded by the PPIB gene), FKBP13 (FKBP2), FKBP19 (FKBP11), FKBP22 (FKBP14), FKBP23 (FKBP7), and FKBP65 (FKBP10), due to posttranslational modifications of proline residues in the substrate.
Title: Ziploc-ing the structure 2.0: Endoplasmic reticulum-resident peptidyl prolyl isomerases show different activities toward hydroxyproline.

this report describes a potentially life-threatening vascular complication in early pediatric age and atlantoaxial instability, suggesting the need for FKBP14-related EDS patients of tailored follow-up that includes cardiovascular monitoring, that is, cerebral, thoracic and abdominal MRA, and cervical dynamic radiograph.
Title: Further delineation of FKBP14-related Ehlers-Danlos syndrome: A patient with early vascular complications and non-progressive kyphoscoliosis, and literature review.

FKBP14 may act as an oncogene in osteosarcoma via suppressing apoptosis and promoting invasion and adhesion in osteosarcoma carcinogenesis
Title: FKBP14 overexpression contributes to osteosarcoma carcinogenesis and indicates poor survival outcome.

Reduced expression of FKBP14 markedly impaired the proliferative ability of ovarian cancer cells. Additionally, ovarian cancer cells infected with FKBP14 shRNA lentivirus tended to arrest in the G0/G1 phase and undergo apoptosis.
Title: RNAi-Mediated Downregulation of FKBP14 Suppresses the Growth of Human Ovarian Cancer Cells.

FKBP14 expression was elevated in ovarian cancer tissues when compared with matched normal tissues. Lentiviral shRNA mediated knockdown of FKBP14 and suppressed the growth of ovarian cancer cells via arresting the cell cycle in the G0/G1 phase and stimulating cell apoptosis. Moreover, cell apoptosis induced by FKBP14 RNAi was mediated by enhancing the ratio of Bax/Bcl-2.
Title: RNAi-Mediated Downregulation of FKBP14 Suppresses the Growth of Human Ovarian Cancer Cells.

The following FKBP14 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the FKBP14 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu23753	NM_017946.4 Latest version!	Homo sapiens FKBP prolyl isomerase 14 (FKBP14), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu23753	NM_017946.3	Homo sapiens FKBP prolyl isomerase 14 (FKBP14), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

FKBP14 ( NM_017946.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_060416.1 Homo sapiens FKBP prolyl isomerase 14 (FKBP14), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu23753
Clone ID Related Accession (Same CDS sequence)	NM_017946.3 , NM_017946.4
Accession Version	NM_017946.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 636bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-06-02
Organism	Homo sapiens(human)
Product	peptidyl-prolyl cis-trans isomerase FKBP14 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA166879.1, AK000738.1, AC007285.3 and CR748502.1. This sequence is a reference standard in the RefSeqGene project. On Mar 28, 2012 this sequence version replaced NM_017946.2. Transcript Variant: This variant (1) represents the protein-coding transcript. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660807.67470.1, SRR1803614.187862.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2467148, SAMN03267755 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGAGGCTTT TCTTGTGGAA CGCGGTCTTG ACTCTGTTCG TCACTTCTTT GATTGGGGCT 
TTGATCCCTG AACCAGAAGT GAAAATTGAA GTTCTCCAGA AGCCATTCAT CTGCCATCGC 
AAGACCAAAG GAGGGGATTT GATGTTGGTC CACTATGAAG GCTACTTAGA AAAGGACGGC 
TCCTTATTTC ACTCCACTCA CAAACATAAC AATGGTCAGC CCATTTGGTT TACCCTGGGC 
ATCCTGGAGG CTCTCAAAGG TTGGGACCAG GGCTTGAAAG GAATGTGTGT AGGAGAGAAG 
AGAAAGCTCA TCATTCCTCC TGCTCTGGGC TATGGAAAAG AAGGAAAAGG TAAAATTCCC 
CCAGAAAGTA CACTGATATT TAATATTGAT CTCCTGGAGA TTCGAAATGG ACCAAGATCC 
CATGAATCAT TCCAAGAAAT GGATCTTAAT GATGACTGGA AACTCTCTAA AGATGAGGTT 
AAAGCATATT TAAAGAAGGA GTTTGAAAAA CATGGTGCGG TGGTGAATGA AAGTCATCAT 
GATGCTTTGG TGGAGGATAT TTTTGATAAA GAAGATGAAG ACAAAGATGG GTTTATATCT 
GCCAGAGAAT TTACATATAA ACACGATGAG TTATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_060416.1
CDS	294..929
Translation	MRLFLWNAVLTLFVTSLIGALIPEPEVKIEVLQKPFICHRKTKGGDLMLVHYEGYLEKDGSLFHSTHKHNNGQPIWFTLGILEALKGWDQGLKGMCVGEKRKLIIPPALGYGKEGKGKIPPESTLIFNIDLLEIRNGPRSHESFQEMDLNDDWKLSKDEVKAYLKKEFEKHGAVVNESHHDALVEDIFDKEDEDKDGFISAREFTYKHDEL

Target ORF information:

RefSeq Version	NM_017946.3
Organism	Homo sapiens(human)
Definition	Homo sapiens FKBP prolyl isomerase 14 (FKBP14), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_017946.3

ORF Insert Sequence:

ATGAGGCTTT TCTTGTGGAA CGCGGTCTTG ACTCTGTTCG TCACTTCTTT GATTGGGGCT 
TTGATCCCTG AACCAGAAGT GAAAATTGAA GTTCTCCAGA AGCCATTCAT CTGCCATCGC 
AAGACCAAAG GAGGGGATTT GATGTTGGTC CACTATGAAG GCTACTTAGA AAAGGACGGC 
TCCTTATTTC ACTCCACTCA CAAACATAAC AATGGTCAGC CCATTTGGTT TACCCTGGGC 
ATCCTGGAGG CTCTCAAAGG TTGGGACCAG GGCTTGAAAG GAATGTGTGT AGGAGAGAAG 
AGAAAGCTCA TCATTCCTCC TGCTCTGGGC TATGGAAAAG AAGGAAAAGG TAAAATTCCC 
CCAGAAAGTA CACTGATATT TAATATTGAT CTCCTGGAGA TTCGAAATGG ACCAAGATCC 
CATGAATCAT TCCAAGAAAT GGATCTTAAT GATGACTGGA AACTCTCTAA AGATGAGGTT 
AAAGCATATT TAAAGAAGGA GTTTGAAAAA CATGGTGCGG TGGTGAATGA AAGTCATCAT 
GATGCTTTGG TGGAGGATAT TTTTGATAAA GAAGATGAAG ACAAAGATGG GTTTATATCT 
GCCAGAGAAT TTACATATAA ACACGATGAG TTATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

FKBP14 ( NM_017946.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_060416.1 Homo sapiens FKBP prolyl isomerase 14 (FKBP14), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu23753
Clone ID Related Accession (Same CDS sequence)	NM_017946.3 , NM_017946.4
Accession Version	NM_017946.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 636bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-14
Organism	Homo sapiens(human)
Product	peptidyl-prolyl cis-trans isomerase FKBP14 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA166879.1, AK000738.1, AC007285.3 and CR748502.1. On Aug 31, 2019 this sequence version replaced NM_017946.3. Transcript Variant: This variant (1) represents the protein-coding transcript. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK000738.1, AY358643.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGAGGCTTT TCTTGTGGAA CGCGGTCTTG ACTCTGTTCG TCACTTCTTT GATTGGGGCT 
TTGATCCCTG AACCAGAAGT GAAAATTGAA GTTCTCCAGA AGCCATTCAT CTGCCATCGC 
AAGACCAAAG GAGGGGATTT GATGTTGGTC CACTATGAAG GCTACTTAGA AAAGGACGGC 
TCCTTATTTC ACTCCACTCA CAAACATAAC AATGGTCAGC CCATTTGGTT TACCCTGGGC 
ATCCTGGAGG CTCTCAAAGG TTGGGACCAG GGCTTGAAAG GAATGTGTGT AGGAGAGAAG 
AGAAAGCTCA TCATTCCTCC TGCTCTGGGC TATGGAAAAG AAGGAAAAGG TAAAATTCCC 
CCAGAAAGTA CACTGATATT TAATATTGAT CTCCTGGAGA TTCGAAATGG ACCAAGATCC 
CATGAATCAT TCCAAGAAAT GGATCTTAAT GATGACTGGA AACTCTCTAA AGATGAGGTT 
AAAGCATATT TAAAGAAGGA GTTTGAAAAA CATGGTGCGG TGGTGAATGA AAGTCATCAT 
GATGCTTTGG TGGAGGATAT TTTTGATAAA GAAGATGAAG ACAAAGATGG GTTTATATCT 
GCCAGAGAAT TTACATATAA ACACGATGAG TTATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_060416.1
CDS	195..830
Translation	MRLFLWNAVLTLFVTSLIGALIPEPEVKIEVLQKPFICHRKTKGGDLMLVHYEGYLEKDGSLFHSTHKHNNGQPIWFTLGILEALKGWDQGLKGMCVGEKRKLIIPPALGYGKEGKGKIPPESTLIFNIDLLEIRNGPRSHESFQEMDLNDDWKLSKDEVKAYLKKEFEKHGAVVNESHHDALVEDIFDKEDEDKDGFISAREFTYKHDEL

Target ORF information:

RefSeq Version	NM_017946.4
Organism	Homo sapiens(human)
Definition	Homo sapiens FKBP prolyl isomerase 14 (FKBP14), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_017946.4

ORF Insert Sequence:

ATGAGGCTTT TCTTGTGGAA CGCGGTCTTG ACTCTGTTCG TCACTTCTTT GATTGGGGCT 
TTGATCCCTG AACCAGAAGT GAAAATTGAA GTTCTCCAGA AGCCATTCAT CTGCCATCGC 
AAGACCAAAG GAGGGGATTT GATGTTGGTC CACTATGAAG GCTACTTAGA AAAGGACGGC 
TCCTTATTTC ACTCCACTCA CAAACATAAC AATGGTCAGC CCATTTGGTT TACCCTGGGC 
ATCCTGGAGG CTCTCAAAGG TTGGGACCAG GGCTTGAAAG GAATGTGTGT AGGAGAGAAG 
AGAAAGCTCA TCATTCCTCC TGCTCTGGGC TATGGAAAAG AAGGAAAAGG TAAAATTCCC 
CCAGAAAGTA CACTGATATT TAATATTGAT CTCCTGGAGA TTCGAAATGG ACCAAGATCC 
CATGAATCAT TCCAAGAAAT GGATCTTAAT GATGACTGGA AACTCTCTAA AGATGAGGTT 
AAAGCATATT TAAAGAAGGA GTTTGAAAAA CATGGTGCGG TGGTGAATGA AAGTCATCAT 
GATGCTTTGG TGGAGGATAT TTTTGATAAA GAAGATGAAG ACAAAGATGG GTTTATATCT 
GCCAGAGAAT TTACATATAA ACACGATGAG TTATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Inhibitory effects of FKBP14 on human cervical cancer cells.
Molecular medicine reports16(4)4265-4272(2017 Oct)
Sun LY,Tao JZ,Yan B,Lin JS

Ziploc-ing the structure 2.0: Endoplasmic reticulum-resident peptidyl prolyl isomerases show different activities toward hydroxyproline.
The Journal of biological chemistry292(22)9273-9282(2017 06)
Ishikawa Y,Mizuno K,B?chinger HP

Ehlers-Danlos syndrome related to FKBP14 mutations: detailed cutaneous phenotype.
Clinical and experimental dermatology42(1)64-67(2017 Jan)
Bursztejn AC,Baumann M,Lipsker D

RNAi-Mediated Downregulation of FKBP14 Suppresses the Growth of Human Ovarian Cancer Cells.
Oncology research23(6)267-274(2016 May)
Lu M,Miao Y,Qi L,Bai M,Zhang J,Feng Y