HSPA14 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	HSPA14
Entrez Gene ID	51182
Full Name	heat shock protein family A (Hsp70) member 14
Synonyms	HSP70-4,HSP70L1
General protein information	Preferred Names heat shock protein family A (Hsp70) member 14 Names heat shock 70 kDa protein 14 HSP70-like protein 1 heat shock 70kDa protein 14 isoform 1 variant 3 heat shock protein HSP60 heat shock protein hsp70-related protein
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 10 Map Location: 10p13
Disorder MIM:	610369

mRNA and Protein(s)

mRNA	Protein	Name
NM_016299.3	NP_057383.2	heat shock 70 kDa protein 14 isoform 1
NM_001278205.1	NP_001265134.1	heat shock 70 kDa protein 14 isoform 3
NM_016299.4	NP_057383.2	heat shock 70 kDa protein 14 isoform 1

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Hspa14	NP_001004257.1
Canis lupus familiaris (dog)	HSPA14	XP_535180.2
Mus musculus (house mouse)	Hspa14	NP_056580.2
Pan troglodytes (chimpanzee)	HSPA14	NP_001233301.1
	HSPA14	XP_001088421.1
Bos taurus (cattle)	HSPA14	NP_001039853.1
Homo sapiens (human)	HSPA14	NP_057383.2
Danio rerio (zebrafish)	hspa14	NP_001038541.1
Xenopus tropicalis (tropical clawed frog)	hspa14	NP_001015780.1
Gallus gallus (chicken)	HSPA14	XP_416996.3

Gene Ontology
Bibliography

Related articles in PubMed

Toll-like receptor 4 (TLR4) is essential for Hsp70-like protein 1 (HSP70L1) to activate dendritic cells and induce Th1 response.
Fang H, Wu Y, Huang X, Wang W, Ang B, Cao X, Wan T
The Journal of biological chemistry286(35)30393-400(2011 Sep)

The diverse members of the mammalian HSP70 machine show distinct chaperone-like activities.
Hageman J, van Waarde MA, Zylicz A, Walerych D, Kampinga HH
The Biochemical journal435(1)127-42(2011 Apr)

Induction of HSPA4 and HSPA14 by NBS1 overexpression contributes to NBS1-induced in vitro metastatic and transformation activity.
Wu CY, Lin CT, Wu MZ, Wu KJ
Journal of biomedical science181(2011 Jan)

Genetic variation and antioxidant response gene expression in the bronchial airway epithelium of smokers at risk for lung cancer.
Wang X, Chorley BN, Pittman GS, Kleeberger SR, Brothers J 2nd, Liu G, Spira A, Bell DA
PloS one5(8)e11934(2010 Aug)

Defining the membrane proteome of NK cells.
Ghosh D, Lippert D, Krokhin O, Cortens JP, Wilkins JA
Journal of mass spectrometry : JMS45(1)1-25(2010 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

TLR4 is a key receptor mediating the interaction of Hsp70L1 with DCs and subsequently enhancing the induction of Th1 immune response by Hsp70L1/antigen fusion protein
Title: Toll-like receptor 4 (TLR4) is essential for Hsp70-like protein 1 (HSP70L1) to activate dendritic cells and induce Th1 response.

a novel pathway (NBS1-HSF4b-HSPA4/HSPA14 axis) to induce migration, invasion, and transformation, suggesting the activation of multiple signaling events induced by NBS1 overexpression
Title: Induction of HSPA4 and HSPA14 by NBS1 overexpression contributes to NBS1-induced in vitro metastatic and transformation activity.

Observational study of gene-disease association. (HuGE Navigator)
Title: Genetic variation and antioxidant response gene expression in the bronchial airway epithelium of smokers at risk for lung cancer.

Observational study of gene-disease association. (HuGE Navigator)
Title: Racial disparity in pathophysiologic pathways of preterm birth based on genetic variants.

Observational study of gene-disease association. (HuGE Navigator)
Title: Spontaneous preterm birth in African Americans is associated with infection and inflammatory response gene variants.

The following HSPA14 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the HSPA14 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu00591	NM_016299.4 Latest version!	Homo sapiens heat shock protein family A (Hsp70) member 14 (HSPA14), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
OHu04349	NM_001278205.1 Latest version!	Homo sapiens heat shock protein family A (Hsp70) member 14 (HSPA14), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
View Old Accession Versions >>
OHu00591	NM_016299.3	Homo sapiens heat shock protein family A (Hsp70) member 14 (HSPA14), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

HSPA14 ( NM_016299.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_057383.2 Homo sapiens heat shock protein family A (Hsp70) member 14 (HSPA14), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu00591
Clone ID Related Accession (Same CDS sequence)	NM_016299.3 , NM_016299.4
Accession Version	NM_016299.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1530bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-02
Organism	Homo sapiens(human)
Product	heat shock 70 kDa protein 14 isoform 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BP201211.1, BC119690.1 and AF112210.1. On May 16, 2013 this sequence version replaced NM_016299.2. Transcript Variant: This variant (1) encodes the longer protein (isoform 1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK225651.1, SRR1660805.62036.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCGGCCA TCGGAGTTCA CCTGGGCTGC ACCTCAGCCT GTGTGGCCGT CTATAAGGAT 
GGCCGGGCTG GTGTGGTTGC AAATGATGCC GGTGACCGAG TTACTCCAGC TGTTGTTGCT 
TACTCAGAAA ATGAAGAGAT TGTTGGATTG GCAGCAAAAC AAAGTAGAAT AAGAAATATT 
TCAAATACAG TAATGAAAGT AAAGCAGATC CTGGGCAGAA GCTCCAGTGA TCCACAAGCT 
CAGAAATACA TCGCGGAAAG TAAATGTTTA GTCATTGAAA AAAATGGGAA ATTACGATAT 
GAAATAGATA CTGGAGAAGA AACAAAATTT GTTAACCCAG AAGATGTTGC CAGACTGATA 
TTTAGTAAAA TGAAAGAAAC GGCACATTCT GTATTGGGCT CAGATGCAAA TGATGTAGTT 
ATTACTGTCC CGTTTGATTT TGGAGAAAAG CAAAAAAATG CTCTTGGAGA AGCAGCTAGA 
GCTGCTGGAT TTAATGTTTT GCGATTAATT CACGAACCGT CTGCAGCTCT TCTTGCTTAT 
GGAATTGGAC AAGACTCCCC TACTGGAAAA AGCAATATTT TGGTGTTTAA GCTTGGAGGA 
ACATCCTTAT CTCTCAGCGT CATGGAAGTT AACAGTGGAA TATATCGGGT TCTTTCAACA 
AACACTGATG ATAACATCGG TGGTGCACAT TTCACAGAAA CCTTAGCACA GTATCTAGCT 
TCTGAGTTCC AAAGATCCTT CAAACATGAT GTGAGAGGAA ATGCGCGAGC CATGATGAAA 
TTAACGAACA GTGCTGAAGT AGCGAAACAT TCTTTGTCAA CCTTGGGAAG TGCCAACTGT 
TTTCTTGACT CATTATATGA AGGTCAAGAT TTTGATTGCA ATGTGTCCAG AGCAAGATTT 
GAACTTCTTT GTTCTCCACT TTTTAATAAG TGTATAGAAG CAATCAGAGG ACTCTTAGAT 
CAAAATGGAT TTACAGCAGA TGATATCAAC AAGGTTGTCC TTTGTGGAGG GTCTTCTCGA 
ATCCCAAAGC TACAGCAACT GATTAAAGAT CTTTTCCCAG CTGTTGAGCT TCTCAATTCT 
ATCCCTCCTG ATGAAGTGAT CCCTATTGGT GCAGCTATAG AAGCAGGAAT TCTTATTGGG 
AAAGAAAACC TGTTGGTGGA AGACTCTCTT ATGATAGAGT GTTCAGCCAG AGATATTTTA 
GTTAAGGGTG TGGACGAATC AGGAGCCAGT AGATTCACAG TGCTGTTTCC ATCAGGGACT 
CCTTTGCCAG CTCGAAGACA ACACACATTG CAAGCCCCTG GAAGCATATC TTCAGTGTGC 
CTTGAACTCT ATGAGTCTGA TGGGAAGAAC TCTGCCAAAG AGGAAACCAA GTTTGCACAG 
GTTGTACTCC AGGATTTAGA TAAAAAAGAA AATGGATTAC GTGATATATT AGCTGTTCTT 
ACTATGAAAA GGGATGGATC TTTACATGTG ACATGCACAG ATCAAGAAAC TGGAAAATGT 
GAAGCAATCT CTATTGAGAT AGCATCTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_057383.2
CDS	244..1773
Translation	MAAIGVHLGCTSACVAVYKDGRAGVVANDAGDRVTPAVVAYSENEEIVGLAAKQSRIRNISNTVMKVKQILGRSSSDPQAQKYIAESKCLVIEKNGKLRYEIDTGEETKFVNPEDVARLIFSKMKETAHSVLGSDANDVVITVPFDFGEKQKNALGEAARAAGFNVLRLIHEPSAALLAYGIGQDSPTGKSNILVFKLGGTSLSLSVMEVNSGIYRVLSTNTDDNIGGAHFTETLAQYLASEFQRSFKHDVRGNARAMMKLTNSAEVAKHSLSTLGSANCFLDSLYEGQDFDCNVSRARFELLCSPLFNKCIEAIRGLLDQNGFTADDINKVVLCGGSSRIPKLQQLIKDLFPAVELLNSIPPDEVIPIGAAIEAGILIGKENLLVEDSLMIECSARDILVKGVDESGASRFTVLFPSGTPLPARRQHTLQAPGSISSVCLELYESDGKNSAKEETKFAQVVLQDLDKKENGLRDILAVLTMKRDGSLHVTCTDQETGKCEAISIEIAS

Target ORF information:

RefSeq Version	NM_016299.3
Organism	Homo sapiens(human)
Definition	Homo sapiens heat shock protein family A (Hsp70) member 14 (HSPA14), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_016299.3

ORF Insert Sequence:

ATGGCGGCCA TCGGAGTTCA CCTGGGCTGC ACCTCAGCCT GTGTGGCCGT CTATAAGGAT 
GGCCGGGCTG GTGTGGTTGC AAATGATGCC GGTGACCGAG TTACTCCAGC TGTTGTTGCT 
TACTCAGAAA ATGAAGAGAT TGTTGGATTG GCAGCAAAAC AAAGTAGAAT AAGAAATATT 
TCAAATACAG TAATGAAAGT AAAGCAGATC CTGGGCAGAA GCTCCAGTGA TCCACAAGCT 
CAGAAATACA TCGCGGAAAG TAAATGTTTA GTCATTGAAA AAAATGGGAA ATTACGATAT 
GAAATAGATA CTGGAGAAGA AACAAAATTT GTTAACCCAG AAGATGTTGC CAGACTGATA 
TTTAGTAAAA TGAAAGAAAC GGCACATTCT GTATTGGGCT CAGATGCAAA TGATGTAGTT 
ATTACTGTCC CGTTTGATTT TGGAGAAAAG CAAAAAAATG CTCTTGGAGA AGCAGCTAGA 
GCTGCTGGAT TTAATGTTTT GCGATTAATT CACGAACCGT CTGCAGCTCT TCTTGCTTAT 
GGAATTGGAC AAGACTCCCC TACTGGAAAA AGCAATATTT TGGTGTTTAA GCTTGGAGGA 
ACATCCTTAT CTCTCAGCGT CATGGAAGTT AACAGTGGAA TATATCGGGT TCTTTCAACA 
AACACTGATG ATAACATCGG TGGTGCACAT TTCACAGAAA CCTTAGCACA GTATCTAGCT 
TCTGAGTTCC AAAGATCCTT CAAACATGAT GTGAGAGGAA ATGCGCGAGC CATGATGAAA 
TTAACGAACA GTGCTGAAGT AGCGAAACAT TCTTTGTCAA CCTTGGGAAG TGCCAACTGT 
TTTCTTGACT CATTATATGA AGGTCAAGAT TTTGATTGCA ATGTGTCCAG AGCAAGATTT 
GAACTTCTTT GTTCTCCACT TTTTAATAAG TGTATAGAAG CAATCAGAGG ACTCTTAGAT 
CAAAATGGAT TTACAGCAGA TGATATCAAC AAGGTTGTCC TTTGTGGAGG GTCTTCTCGA 
ATCCCAAAGC TACAGCAACT GATTAAAGAT CTTTTCCCAG CTGTTGAGCT TCTCAATTCT 
ATCCCTCCTG ATGAAGTGAT CCCTATTGGT GCAGCTATAG AAGCAGGAAT TCTTATTGGG 
AAAGAAAACC TGTTGGTGGA AGACTCTCTT ATGATAGAGT GTTCAGCCAG AGATATTTTA 
GTTAAGGGTG TGGACGAATC AGGAGCCAGT AGATTCACAG TGCTGTTTCC ATCAGGGACT 
CCTTTGCCAG CTCGAAGACA ACACACATTG CAAGCCCCTG GAAGCATATC TTCAGTGTGC 
CTTGAACTCT ATGAGTCTGA TGGGAAGAAC TCTGCCAAAG AGGAAACCAA GTTTGCACAG 
GTTGTACTCC AGGATTTAGA TAAAAAAGAA AATGGATTAC GTGATATATT AGCTGTTCTT 
ACTATGAAAA GGGATGGATC TTTACATGTG ACATGCACAG ATCAAGAAAC TGGAAAATGT 
GAAGCAATCT CTATTGAGAT AGCATCTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HSPA14 ( NM_016299.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_057383.2 Homo sapiens heat shock protein family A (Hsp70) member 14 (HSPA14), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu00591
Clone ID Related Accession (Same CDS sequence)	NM_016299.3 , NM_016299.4
Accession Version	NM_016299.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1530bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-05-01
Organism	Homo sapiens(human)
Product	heat shock 70 kDa protein 14 isoform 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BP201211.1, BC119690.1 and AF112210.1. On Nov 23, 2018 this sequence version replaced NM_016299.3. Transcript Variant: This variant (1) encodes the longer protein (isoform 1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR3476690.312741.1, SRR1660809.169459.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000378372.8/ ENSP00000367623.3 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCGGCCA TCGGAGTTCA CCTGGGCTGC ACCTCAGCCT GTGTGGCCGT CTATAAGGAT 
GGCCGGGCTG GTGTGGTTGC AAATGATGCC GGTGACCGAG TTACTCCAGC TGTTGTTGCT 
TACTCAGAAA ATGAAGAGAT TGTTGGATTG GCAGCAAAAC AAAGTAGAAT AAGAAATATT 
TCAAATACAG TAATGAAAGT AAAGCAGATC CTGGGCAGAA GCTCCAGTGA TCCACAAGCT 
CAGAAATACA TCGCGGAAAG TAAATGTTTA GTCATTGAAA AAAATGGGAA ATTACGATAT 
GAAATAGATA CTGGAGAAGA AACAAAATTT GTTAACCCAG AAGATGTTGC CAGACTGATA 
TTTAGTAAAA TGAAAGAAAC GGCACATTCT GTATTGGGCT CAGATGCAAA TGATGTAGTT 
ATTACTGTCC CGTTTGATTT TGGAGAAAAG CAAAAAAATG CTCTTGGAGA AGCAGCTAGA 
GCTGCTGGAT TTAATGTTTT GCGATTAATT CACGAACCGT CTGCAGCTCT TCTTGCTTAT 
GGAATTGGAC AAGACTCCCC TACTGGAAAA AGCAATATTT TGGTGTTTAA GCTTGGAGGA 
ACATCCTTAT CTCTCAGCGT CATGGAAGTT AACAGTGGAA TATATCGGGT TCTTTCAACA 
AACACTGATG ATAACATCGG TGGTGCACAT TTCACAGAAA CCTTAGCACA GTATCTAGCT 
TCTGAGTTCC AAAGATCCTT CAAACATGAT GTGAGAGGAA ATGCGCGAGC CATGATGAAA 
TTAACGAACA GTGCTGAAGT AGCGAAACAT TCTTTGTCAA CCTTGGGAAG TGCCAACTGT 
TTTCTTGACT CATTATATGA AGGTCAAGAT TTTGATTGCA ATGTGTCCAG AGCAAGATTT 
GAACTTCTTT GTTCTCCACT TTTTAATAAG TGTATAGAAG CAATCAGAGG ACTCTTAGAT 
CAAAATGGAT TTACAGCAGA TGATATCAAC AAGGTTGTCC TTTGTGGAGG GTCTTCTCGA 
ATCCCAAAGC TACAGCAACT GATTAAAGAT CTTTTCCCAG CTGTTGAGCT TCTCAATTCT 
ATCCCTCCTG ATGAAGTGAT CCCTATTGGT GCAGCTATAG AAGCAGGAAT TCTTATTGGG 
AAAGAAAACC TGTTGGTGGA AGACTCTCTT ATGATAGAGT GTTCAGCCAG AGATATTTTA 
GTTAAGGGTG TGGACGAATC AGGAGCCAGT AGATTCACAG TGCTGTTTCC ATCAGGGACT 
CCTTTGCCAG CTCGAAGACA ACACACATTG CAAGCCCCTG GAAGCATATC TTCAGTGTGC 
CTTGAACTCT ATGAGTCTGA TGGGAAGAAC TCTGCCAAAG AGGAAACCAA GTTTGCACAG 
GTTGTACTCC AGGATTTAGA TAAAAAAGAA AATGGATTAC GTGATATATT AGCTGTTCTT 
ACTATGAAAA GGGATGGATC TTTACATGTG ACATGCACAG ATCAAGAAAC TGGAAAATGT 
GAAGCAATCT CTATTGAGAT AGCATCTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_057383.2
CDS	98..1627
Translation	MAAIGVHLGCTSACVAVYKDGRAGVVANDAGDRVTPAVVAYSENEEIVGLAAKQSRIRNISNTVMKVKQILGRSSSDPQAQKYIAESKCLVIEKNGKLRYEIDTGEETKFVNPEDVARLIFSKMKETAHSVLGSDANDVVITVPFDFGEKQKNALGEAARAAGFNVLRLIHEPSAALLAYGIGQDSPTGKSNILVFKLGGTSLSLSVMEVNSGIYRVLSTNTDDNIGGAHFTETLAQYLASEFQRSFKHDVRGNARAMMKLTNSAEVAKHSLSTLGSANCFLDSLYEGQDFDCNVSRARFELLCSPLFNKCIEAIRGLLDQNGFTADDINKVVLCGGSSRIPKLQQLIKDLFPAVELLNSIPPDEVIPIGAAIEAGILIGKENLLVEDSLMIECSARDILVKGVDESGASRFTVLFPSGTPLPARRQHTLQAPGSISSVCLELYESDGKNSAKEETKFAQVVLQDLDKKENGLRDILAVLTMKRDGSLHVTCTDQETGKCEAISIEIAS

Target ORF information:

RefSeq Version	NM_016299.4
Organism	Homo sapiens(human)
Definition	Homo sapiens heat shock protein family A (Hsp70) member 14 (HSPA14), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_016299.4

ORF Insert Sequence:

ATGGCGGCCA TCGGAGTTCA CCTGGGCTGC ACCTCAGCCT GTGTGGCCGT CTATAAGGAT 
GGCCGGGCTG GTGTGGTTGC AAATGATGCC GGTGACCGAG TTACTCCAGC TGTTGTTGCT 
TACTCAGAAA ATGAAGAGAT TGTTGGATTG GCAGCAAAAC AAAGTAGAAT AAGAAATATT 
TCAAATACAG TAATGAAAGT AAAGCAGATC CTGGGCAGAA GCTCCAGTGA TCCACAAGCT 
CAGAAATACA TCGCGGAAAG TAAATGTTTA GTCATTGAAA AAAATGGGAA ATTACGATAT 
GAAATAGATA CTGGAGAAGA AACAAAATTT GTTAACCCAG AAGATGTTGC CAGACTGATA 
TTTAGTAAAA TGAAAGAAAC GGCACATTCT GTATTGGGCT CAGATGCAAA TGATGTAGTT 
ATTACTGTCC CGTTTGATTT TGGAGAAAAG CAAAAAAATG CTCTTGGAGA AGCAGCTAGA 
GCTGCTGGAT TTAATGTTTT GCGATTAATT CACGAACCGT CTGCAGCTCT TCTTGCTTAT 
GGAATTGGAC AAGACTCCCC TACTGGAAAA AGCAATATTT TGGTGTTTAA GCTTGGAGGA 
ACATCCTTAT CTCTCAGCGT CATGGAAGTT AACAGTGGAA TATATCGGGT TCTTTCAACA 
AACACTGATG ATAACATCGG TGGTGCACAT TTCACAGAAA CCTTAGCACA GTATCTAGCT 
TCTGAGTTCC AAAGATCCTT CAAACATGAT GTGAGAGGAA ATGCGCGAGC CATGATGAAA 
TTAACGAACA GTGCTGAAGT AGCGAAACAT TCTTTGTCAA CCTTGGGAAG TGCCAACTGT 
TTTCTTGACT CATTATATGA AGGTCAAGAT TTTGATTGCA ATGTGTCCAG AGCAAGATTT 
GAACTTCTTT GTTCTCCACT TTTTAATAAG TGTATAGAAG CAATCAGAGG ACTCTTAGAT 
CAAAATGGAT TTACAGCAGA TGATATCAAC AAGGTTGTCC TTTGTGGAGG GTCTTCTCGA 
ATCCCAAAGC TACAGCAACT GATTAAAGAT CTTTTCCCAG CTGTTGAGCT TCTCAATTCT 
ATCCCTCCTG ATGAAGTGAT CCCTATTGGT GCAGCTATAG AAGCAGGAAT TCTTATTGGG 
AAAGAAAACC TGTTGGTGGA AGACTCTCTT ATGATAGAGT GTTCAGCCAG AGATATTTTA 
GTTAAGGGTG TGGACGAATC AGGAGCCAGT AGATTCACAG TGCTGTTTCC ATCAGGGACT 
CCTTTGCCAG CTCGAAGACA ACACACATTG CAAGCCCCTG GAAGCATATC TTCAGTGTGC 
CTTGAACTCT ATGAGTCTGA TGGGAAGAAC TCTGCCAAAG AGGAAACCAA GTTTGCACAG 
GTTGTACTCC AGGATTTAGA TAAAAAAGAA AATGGATTAC GTGATATATT AGCTGTTCTT 
ACTATGAAAA GGGATGGATC TTTACATGTG ACATGCACAG ATCAAGAAAC TGGAAAATGT 
GAAGCAATCT CTATTGAGAT AGCATCTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HSPA14 ( NM_001278205.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001265134.1 Homo sapiens heat shock protein family A (Hsp70) member 14 (HSPA14), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu04349
Clone ID Related Accession (Same CDS sequence)	NM_001278205.1
Accession Version	NM_001278205.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 432bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-06-24
Organism	Homo sapiens(human)
Product	heat shock 70 kDa protein 14 isoform 3
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BP201211.1, BC038845.1 and BC026226.1. Transcript Variant: This variant (3) contains an alternate 3' exon in place of the last several exons compared to variant 1. The resulting isoform (3) has a shorter and distinct C-terminus compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC038845.1, SRR1163655.403984.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCGGCCA TCGGAGTTCA CCTGGGCTGC ACCTCAGCCT GTGTGGCCGT CTATAAGGAT 
GGCCGGGCTG GTGTGGTTGC AAATGATGCC GGTGACCGAG TTACTCCAGC TGTTGTTGCT 
TACTCAGAAA ATGAAGAGAT TGTTGGATTG GCAGCAAAAC AAAGTAGAAT AAGAAATATT 
TCAAATACAG TAATGAAAGT AAAGCAGATC CTGGGCAGAA GGGTGCTCTC AAGGGACCCC 
CAGCTACAGC AGCTCCCACA GCCTTTTCAG AGGTGCAGTT GCTCCCTGTC AGAGCAGCCC 
CATGGCCAGA CTGGGTGTGT CCGGGGAGCC CAGCCCCTGC ACCAGCACCA ACCGCAGCAC 
TCCTGGGGTA GCCTCCACAC CGCAGACTCC AGTCTCCTCT TCGAGAGCTG GTTTTGTTTC 
TGGTGGGGAT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001265134.1
CDS	244..675
Translation	MAAIGVHLGCTSACVAVYKDGRAGVVANDAGDRVTPAVVAYSENEEIVGLAAKQSRIRNISNTVMKVKQILGRRVLSRDPQLQQLPQPFQRCSCSLSEQPHGQTGCVRGAQPLHQHQPQHSWGSLHTADSSLLFESWFCFWWG

Target ORF information:

RefSeq Version	NM_001278205.1
Organism	Homo sapiens(human)
Definition	Homo sapiens heat shock protein family A (Hsp70) member 14 (HSPA14), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001278205.1

ORF Insert Sequence:

ATGGCGGCCA TCGGAGTTCA CCTGGGCTGC ACCTCAGCCT GTGTGGCCGT CTATAAGGAT 
GGCCGGGCTG GTGTGGTTGC AAATGATGCC GGTGACCGAG TTACTCCAGC TGTTGTTGCT 
TACTCAGAAA ATGAAGAGAT TGTTGGATTG GCAGCAAAAC AAAGTAGAAT AAGAAATATT 
TCAAATACAG TAATGAAAGT AAAGCAGATC CTGGGCAGAA GGGTGCTCTC AAGGGACCCC 
CAGCTACAGC AGCTCCCACA GCCTTTTCAG AGGTGCAGTT GCTCCCTGTC AGAGCAGCCC 
CATGGCCAGA CTGGGTGTGT CCGGGGAGCC CAGCCCCTGC ACCAGCACCA ACCGCAGCAC 
TCCTGGGGTA GCCTCCACAC CGCAGACTCC AGTCTCCTCT TCGAGAGCTG GTTTTGTTTC 
TGGTGGGGAT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Toll-like receptor 4 (TLR4) is essential for Hsp70-like protein 1 (HSP70L1) to activate dendritic cells and induce Th1 response.
The Journal of biological chemistry286(35)30393-400(2011 Sep)
Fang H,Wu Y,Huang X,Wang W,Ang B,Cao X,Wan T

The diverse members of the mammalian HSP70 machine show distinct chaperone-like activities.
The Biochemical journal435(1)127-42(2011 Apr)
Hageman J,van Waarde MA,Zylicz A,Walerych D,Kampinga HH

Induction of HSPA4 and HSPA14 by NBS1 overexpression contributes to NBS1-induced in vitro metastatic and transformation activity.
Journal of biomedical science181(2011 Jan)
Wu CY,Lin CT,Wu MZ,Wu KJ

Genetic variation and antioxidant response gene expression in the bronchial airway epithelium of smokers at risk for lung cancer.
PloS one5(8)e11934(2010 Aug)
Wang X,Chorley BN,Pittman GS,Kleeberger SR,Brothers J 2nd,Liu G,Spira A,Bell DA

Defining the membrane proteome of NK cells.
Journal of mass spectrometry : JMS45(1)1-25(2010 Jan)
Ghosh D,Lippert D,Krokhin O,Cortens JP,Wilkins JA