MSH4 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	MSH4
Entrez Gene ID	4438
Full Name	mutS homolog 4
General protein information	Preferred Names mutS homolog 4 Names mutS protein homolog 4 hMSH4
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 1 Map Location: 1p31.1
Summary	This gene encodes a member of the DNA mismatch repair mutS family. This member is a meiosis-specific protein that is not involved in DNA mismatch correction, but is required for reciprocal recombination and proper segregation of homologous chromosomes at meiosis I. This protein and MSH5 form a heterodimer which binds uniquely to a Holliday Junction and its developmental progenitor, thus provoking ADP-ATP exchange, and stabilizing the interaction between parental chromosomes during meiosis double-stranded break repair. [provided by RefSeq, Aug 2011].
Disorder MIM:	602105

mRNA and Protein(s)

mRNA	Protein	Name
NM_002440.3	NP_002431.2	mutS protein homolog 4
NM_002440.4	NP_002431.2	mutS protein homolog 4

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	MSH4	XP_524742.2
Kluyveromyces lactis	KLLA0F11022g	XP_455582.1
Canis lupus familiaris (dog)	MSH4	XP_005622187.1
Danio rerio (zebrafish)	msh4	XP_688406.1
Caenorhabditis elegans (roundworm)	him-14	NP_495451.1
Magnaporthe oryzae (rice blast fungus)	MGG_08738	XP_003719247.1
Arabidopsis thaliana (thale cress)	MSH4	NP_193469.2
Homo sapiens (human)	MSH4	NP_002431.2
	MSH4	XP_001101368.1
Gallus gallus (chicken)	MSH4	XP_004936961.1
Mus musculus (house mouse)	Msh4	NP_114076.1
Rattus norvegicus (Norway rat)	Msh4	NP_001099947.2
Saccharomyces cerevisiae (baker's yeast)	MSH4	NP_116652.1
Xenopus tropicalis (tropical clawed frog)	msh4	XP_002936134.2
Bos taurus (cattle)	MSH4	NP_001193184.1
Oryza sativa (rice)	Os07g0486000	NP_001175201.1

Gene Ontology
Bibliography

Related articles in PubMed

A homozygous donor splice-site mutation in the meiotic gene MSH4 causes primary ovarian insufficiency.
Carlosama C, Elzaiat M, Pati?o LC, Mateus HE, Veitia RA, Laissue P
Human molecular genetics26(16)3161-3166(2017 Aug)

TP53, MSH4, and LATS1 germline mutations in a family with clustering of nervous system tumors.
Kim YH, Ohta T, Oh JE, Le Calvez-Kelm F, McKay J, Voegele C, Durand G, Mittelbronn M, Kleihues P, Paulus W, Ohgaki H
The American journal of pathology184(9)2374-81(2014 Sep)

DNA damage induced MutS homologue hMSH4 acetylation.
Chu YL, Wu X, Xu J, Watts JL, Her C
International journal of molecular sciences14(10)20966-82(2013 Oct)

MutS homologue hMSH4: interaction with eIF3f and a role in NHEJ-mediated DSB repair.
Chu YL, Wu X, Xu Y, Her C
Molecular cancer1251(2013 Jun)

MutS homologue hMSH5: role in cisplatin-induced DNA damage response.
Tompkins JD, Wu X, Her C
Molecular cancer1110(2012 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Study describes the first MSH4 mutation associated with POI and increases the number of meiotic/DNA repair genes formally implicated as being responsible for this condition.
Title: A homozygous donor splice-site mutation in the meiotic gene MSH4 causes primary ovarian insufficiency.

inactivation of MSH4 in germ cells may have played a role in the acquisition of additional TP53 and LATS1 germline mutations in a Li-Fraumeni family
Title: TP53, MSH4, and LATS1 germline mutations in a family with clustering of nervous system tumors.

hMSH4 interacts with HDAC3.
Title: DNA damage induced MutS homologue hMSH4 acetylation.

Our current study has revealed a role for hMSH4 in the maintenance of genomic stability by suppressing NHEJ-mediated DSB repair.
Title: MutS homologue hMSH4: interaction with eIF3f and a role in NHEJ-mediated DSB repair.

mutation analysis of SYCP3, DNMT3L and MSH4 in patients with maturation arrest of spermatogenesis and couples with recurrent miscarriages
Title: Mutation analysis of three genes in patients with maturation arrest of spermatogenesis and couples with recurrent miscarriages.

The following MSH4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MSH4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu18512	NM_002440.4 Latest version!	Homo sapiens mutS homolog 4 (MSH4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$475.30 $679.00
View Old Accession Versions >>
OHu18512	NM_002440.3	Homo sapiens mutS homolog 4 (MSH4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$475.30 $679.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

MSH4 ( NM_002440.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_002431.2 Homo sapiens mutS homolog 4 (MSH4), mRNA.

Price & Availability↑

CloneID	OHu18512
Clone ID Related Accession (Same CDS sequence)	NM_002440.3 , NM_002440.4
Accession Version	NM_002440.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2811bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	mutS protein homolog 4
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB077677.1, AF104243.1 and BC033030.1. This sequence is a reference standard in the RefSeqGene project. On Aug 20, 2011 this sequence version replaced NM_002440.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC033030.1, U89293.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2148093 [ECO:0000348] ##Evidence-Data-END##

ATGCTGAGGC CTGAGATCTC ATCAACCTCG CCTTCTGCCC CGGCGGTTTC CCCGTCGTCG 
GGAGAAACCC GCTCACCTCA GGGTCCCCGC TACAATTTCG GACTCCAGGA GACTCCACAG 
AGCCGCCCTT CGGTCCAGGT GGTCTCTGCA TCCACCTGTC CTGGCACGTC AGGAGCTGCG 
GGCGACCGGA GCAGCAGCAG CAGCAGCCTT CCCTGCCCCG CGCCAAACTC CCGGCCAGCT 
CAAGGTTCAT ACTTTGGAAA CAAAAGAGCT TATGCAGAAA ACACAGTTGC ATCAAATTTT 
ACTTTTGGTG CAAGCTCATC TTCTGCACGA GATACTAATT ATCCTCAAAC ACTTAAAACT 
CCATTGTCTA CTGGAAATCC TCAGAGATCA GGTTATAAGA GCTGGACACC ACAAGTGGGA 
TATTCAGCTT CATCCTCATC TGCGATTTCT GCACACTCCC CATCAGTTAT TGTAGCTGTT 
GTAGAAGGGA GAGGACTTGC CAGAGGTGAA ATAGGAATGG CAAGTATTGA TTTAAAAAAC 
CCCCAAATTA TACTATCCCA GTTTGCAGAC AACACAACAT ATGCAAAGGT GATCACTAAA 
CTTAAAATTT TATCACCTTT GGAAATAATA ATGTCAAATA CTGCTTGTGC TGTGGGGAAT 
TCCACCAAGT TGTTCACTCT GATCACAGAA AATTTCAAGA ATGTTAATTT CACTACTATC 
CAAAGGAAAT ACTTCAATGA AACAAAAGGA TTAGAGTACA TTGAACAGTT ATGCATAGCA 
GAATTCAGCA CTGTCCTAAT GGAGGTTCAG TCCAAGTATT ACTGCCTTGC AGCTGTTGCA 
GCTTTGTTAA AATATGTTGA ATTTATTCAA AATTCAGTTT ATGCACCAAA ATCACTGAAG 
ATTTGTTTCC AGGGTAGTGA ACAGACAGCC ATGATAGATT CATCATCAGC CCAAAACCTT 
GAATTGTTAA TTAATAATCA AGACTATAGG AATAATCACA CTCTCTTTGG TGTTCTAAAT 
TATACTAAGA CTCCTGGAGG GAGTAGACGA CTTCGTTCTA ATATATTAGA GCCTCTAGTT 
GATATTGAAA CCATTAACAT GAGATTAGAT TGTGTTCAAG AACTACTTCA AGATGAGGAA 
CTATTTTTTG GACTTCAATC AGTTATATCA AGATTTCTTG ATACAGAGCA GCTTCTTTCT 
GTTTTAGTCC AAATTCCAAA GCAAGACACG GTCAATGCTG CTGAATCAAA GATAACAAAT 
TTAATATACT TAAAACATAC CTTGGAACTT GTGGATCCTT TAAAGATTGC TATGAAGAAC 
TGTAACACAC CTTTATTAAG AGCTTACTAT GGTTCCTTGG AAGACAAGAG GTTTGGAATC 
ATACTTGAAA AGATTAAAAC AGTAATTAAT GATGATGCAA GATACATGAA AGGATGCCTA 
AACATGAGGA CTCAGAAGTG CTATGCAGTG AGGTCTAACA TAAATGAATT TCTTGACATA 
GCAAGAAGAA CATACACAGA GATTGTAGAT GACATAGCAG GAATGATATC ACAACTTGGA 
GAAAAATATA GTCTACCTTT AAGGACAAGT TTTAGCTCTG CTCGAGGATT TTTCATCCAG 
ATGACTACAG ATTGTATAGC CCTACCTAGT GATCAACTTC CTTCAGAATT TATTAAGATT 
TCTAAAGTGA AAAATTCTTA CAGCTTTACA TCAGCAGATT TAATTAAAAT GAATGAAAGA 
TGCCAAGAAT CTTTGAGAGA AATCTATCAC ATGACTTATA TGATAGTGTG CAAACTGCTT 
AGTGAGATTT ATGAACATAT TCATTGCTTA TATAAACTAT CTGACACTGT GTCAATGCTG 
GATATGCTAC TGTCATTTGC TCATGCCTGC ACTCTTTCTG ACTATGTTCG ACCAGAATTT 
ACTGATACTT TAGCAATCAA ACAGGGATGG CATCCTATTC TTGAAAAAAT ATCTGCGGAA 
AAACCTATTG CCAACAATAC CTATGTTACA GAAGGGAGTA ATTTTTTGAT CATAACTGGA 
CCAAACATGA GTGGAAAATC CACATATTTA AAACAGATTG CTCTTTGTCA GATTATGGCC 
CAGATTGGAT CATATGTTCC AGCAGAATAT TCTTCCTTTA GAATTGCTAA ACAGATTTTT 
ACAAGAATTA GTACTGATGA TGATATCGAA ACAAATTCAT CAACATTTAT GAAAGAAATG 
AAAGAGATAG CATATATTCT ACATAATGCT AATGACAAAT CGCTCATATT AATTGATGAA 
CTTGGCAGAG GTACTAATAC GGAAGAAGGT ATTGGCATTT GTTATGCTGT TTGTGAATAT 
CTACTGAGCT TAAAGGCATT TACACTGTTT GCTACACATT TCCTGGAACT ATGCCATATT 
GATGCCCTGT ATCCTAATGT AGAAAACATG CATTTTGAAG TTCAACATGT AAAGAATACC 
TCAAGAAATA AAGAAGCAAT TTTGTATACC TACAAACTTT CTAAGGGACT CACAGAAGAG 
AAAAATTATG GATTAAAAGC TGCAGAGGTG TCATCACTTC CACCATCAAT TGTCTTGGAT 
GCCAAGGAAA TCACAACTCA AATTACGAGA CAAATTTTGC AAAACCAAAG GAGTACCCCT 
GAGATGGAAA GACAGAGAGC TGTGTACCAT CTAGCCACTA GGCTTGTTCA AACTGCTCGA 
AACTCTCAAT TGGATCCAGA CAGTTTACGA ATATATTTAA GTAACCTCAA GAAGAAGTAC 
AAAGAAGATT TTCCCAGGAC TGAACAAGTT CCAGAAAAGA CTGAAGAATA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002431.2
CDS	116..2926
Translation	MLRPEISSTSPSAPAVSPSSGETRSPQGPRYNFGLQETPQSRPSVQVVSASTCPGTSGAAGDRSSSSSSLPCPAPNSRPAQGSYFGNKRAYAENTVASNFTFGASSSSARDTNYPQTLKTPLSTGNPQRSGYKSWTPQVGYSASSSSAISAHSPSVIVAVVEGRGLARGEIGMASIDLKNPQIILSQFADNTTYAKVITKLKILSPLEIIMSNTACAVGNSTKLFTLITENFKNVNFTTIQRKYFNETKGLEYIEQLCIAEFSTVLMEVQSKYYCLAAVAALLKYVEFIQNSVYAPKSLKICFQGSEQTAMIDSSSAQNLELLINNQDYRNNHTLFGVLNYTKTPGGSRRLRSNILEPLVDIETINMRLDCVQELLQDEELFFGLQSVISRFLDTEQLLSVLVQIPKQDTVNAAESKITNLIYLKHTLELVDPLKIAMKNCNTPLLRAYYGSLEDKRFGIILEKIKTVINDDARYMKGCLNMRTQKCYAVRSNINEFLDIARRTYTEIVDDIAGMISQLGEKYSLPLRTSFSSARGFFIQMTTDCIALPSDQLPSEFIKISKVKNSYSFTSADLIKMNERCQESLREIYHMTYMIVCKLLSEIYEHIHCLYKLSDTVSMLDMLLSFAHACTLSDYVRPEFTDTLAIKQGWHPILEKISAEKPIANNTYVTEGSNFLIITGPNMSGKSTYLKQIALCQIMAQIGSYVPAEYSSFRIAKQIFTRISTDDDIETNSSTFMKEMKEIAYILHNANDKSLILIDELGRGTNTEEGIGICYAVCEYLLSLKAFTLFATHFLELCHIDALYPNVENMHFEVQHVKNTSRNKEAILYTYKLSKGLTEEKNYGLKAAEVSSLPPSIVLDAKEITTQITRQILQNQRSTPEMERQRAVYHLATRLVQTARNSQLDPDSLRIYLSNLKKKYKEDFPRTEQVPEKTEE

Target ORF information:

RefSeq Version	NM_002440.3
Organism	Homo sapiens(human)
Definition	Homo sapiens mutS homolog 4 (MSH4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002440.3

ORF Insert Sequence:

ATGCTGAGGC CTGAGATCTC ATCAACCTCG CCTTCTGCCC CGGCGGTTTC CCCGTCGTCG 
GGAGAAACCC GCTCACCTCA GGGTCCCCGC TACAATTTCG GACTCCAGGA GACTCCACAG 
AGCCGCCCTT CGGTCCAGGT GGTCTCTGCA TCCACCTGTC CTGGCACGTC AGGAGCTGCG 
GGCGACCGGA GCAGCAGCAG CAGCAGCCTT CCCTGCCCCG CGCCAAACTC CCGGCCAGCT 
CAAGGTTCAT ACTTTGGAAA CAAAAGAGCT TATGCAGAAA ACACAGTTGC ATCAAATTTT 
ACTTTTGGTG CAAGCTCATC TTCTGCACGA GATACTAATT ATCCTCAAAC ACTTAAAACT 
CCATTGTCTA CTGGAAATCC TCAGAGATCA GGTTATAAGA GCTGGACACC ACAAGTGGGA 
TATTCAGCTT CATCCTCATC TGCGATTTCT GCACACTCCC CATCAGTTAT TGTAGCTGTT 
GTAGAAGGGA GAGGACTTGC CAGAGGTGAA ATAGGAATGG CAAGTATTGA TTTAAAAAAC 
CCCCAAATTA TACTATCCCA GTTTGCAGAC AACACAACAT ATGCAAAGGT GATCACTAAA 
CTTAAAATTT TATCACCTTT GGAAATAATA ATGTCAAATA CTGCTTGTGC TGTGGGGAAT 
TCCACCAAGT TGTTCACTCT GATCACAGAA AATTTCAAGA ATGTTAATTT CACTACTATC 
CAAAGGAAAT ACTTCAATGA AACAAAAGGA TTAGAGTACA TTGAACAGTT ATGCATAGCA 
GAATTCAGCA CTGTCCTAAT GGAGGTTCAG TCCAAGTATT ACTGCCTTGC AGCTGTTGCA 
GCTTTGTTAA AATATGTTGA ATTTATTCAA AATTCAGTTT ATGCACCAAA ATCACTGAAG 
ATTTGTTTCC AGGGTAGTGA ACAGACAGCC ATGATAGATT CATCATCAGC CCAAAACCTT 
GAATTGTTAA TTAATAATCA AGACTATAGG AATAATCACA CTCTCTTTGG TGTTCTAAAT 
TATACTAAGA CTCCTGGAGG GAGTAGACGA CTTCGTTCTA ATATATTAGA GCCTCTAGTT 
GATATTGAAA CCATTAACAT GAGATTAGAT TGTGTTCAAG AACTACTTCA AGATGAGGAA 
CTATTTTTTG GACTTCAATC AGTTATATCA AGATTTCTTG ATACAGAGCA GCTTCTTTCT 
GTTTTAGTCC AAATTCCAAA GCAAGACACG GTCAATGCTG CTGAATCAAA GATAACAAAT 
TTAATATACT TAAAACATAC CTTGGAACTT GTGGATCCTT TAAAGATTGC TATGAAGAAC 
TGTAACACAC CTTTATTAAG AGCTTACTAT GGTTCCTTGG AAGACAAGAG GTTTGGAATC 
ATACTTGAAA AGATTAAAAC AGTAATTAAT GATGATGCAA GATACATGAA AGGATGCCTA 
AACATGAGGA CTCAGAAGTG CTATGCAGTG AGGTCTAACA TAAATGAATT TCTTGACATA 
GCAAGAAGAA CATACACAGA GATTGTAGAT GACATAGCAG GAATGATATC ACAACTTGGA 
GAAAAATATA GTCTACCTTT AAGGACAAGT TTTAGCTCTG CTCGAGGATT TTTCATCCAG 
ATGACTACAG ATTGTATAGC CCTACCTAGT GATCAACTTC CTTCAGAATT TATTAAGATT 
TCTAAAGTGA AAAATTCTTA CAGCTTTACA TCAGCAGATT TAATTAAAAT GAATGAAAGA 
TGCCAAGAAT CTTTGAGAGA AATCTATCAC ATGACTTATA TGATAGTGTG CAAACTGCTT 
AGTGAGATTT ATGAACATAT TCATTGCTTA TATAAACTAT CTGACACTGT GTCAATGCTG 
GATATGCTAC TGTCATTTGC TCATGCCTGC ACTCTTTCTG ACTATGTTCG ACCAGAATTT 
ACTGATACTT TAGCAATCAA ACAGGGATGG CATCCTATTC TTGAAAAAAT ATCTGCGGAA 
AAACCTATTG CCAACAATAC CTATGTTACA GAAGGGAGTA ATTTTTTGAT CATAACTGGA 
CCAAACATGA GTGGAAAATC CACATATTTA AAACAGATTG CTCTTTGTCA GATTATGGCC 
CAGATTGGAT CATATGTTCC AGCAGAATAT TCTTCCTTTA GAATTGCTAA ACAGATTTTT 
ACAAGAATTA GTACTGATGA TGATATCGAA ACAAATTCAT CAACATTTAT GAAAGAAATG 
AAAGAGATAG CATATATTCT ACATAATGCT AATGACAAAT CGCTCATATT AATTGATGAA 
CTTGGCAGAG GTACTAATAC GGAAGAAGGT ATTGGCATTT GTTATGCTGT TTGTGAATAT 
CTACTGAGCT TAAAGGCATT TACACTGTTT GCTACACATT TCCTGGAACT ATGCCATATT 
GATGCCCTGT ATCCTAATGT AGAAAACATG CATTTTGAAG TTCAACATGT AAAGAATACC 
TCAAGAAATA AAGAAGCAAT TTTGTATACC TACAAACTTT CTAAGGGACT CACAGAAGAG 
AAAAATTATG GATTAAAAGC TGCAGAGGTG TCATCACTTC CACCATCAAT TGTCTTGGAT 
GCCAAGGAAA TCACAACTCA AATTACGAGA CAAATTTTGC AAAACCAAAG GAGTACCCCT 
GAGATGGAAA GACAGAGAGC TGTGTACCAT CTAGCCACTA GGCTTGTTCA AACTGCTCGA 
AACTCTCAAT TGGATCCAGA CAGTTTACGA ATATATTTAA GTAACCTCAA GAAGAAGTAC 
AAAGAAGATT TTCCCAGGAC TGAACAAGTT CCAGAAAAGA CTGAAGAATA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MSH4 ( NM_002440.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_002431.2 Homo sapiens mutS homolog 4 (MSH4), mRNA.

Price & Availability↑

CloneID	OHu18512
Clone ID Related Accession (Same CDS sequence)	NM_002440.3 , NM_002440.4
Accession Version	NM_002440.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2811bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Homo sapiens(human)
Product	mutS protein homolog 4
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB077677.1, AF104243.1, BC033030.1 and AL445464.9. This sequence is a reference standard in the RefSeqGene project. On Nov 23, 2018 this sequence version replaced NM_002440.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC033030.1, U89293.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2148093 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000263187.4/ ENSP00000263187.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGCTGAGGC CTGAGATCTC ATCAACCTCG CCTTCTGCCC CGGCGGTTTC CCCGTCGTCG 
GGAGAAACCC GCTCACCTCA GGGTCCCCGC TACAATTTCG GACTCCAGGA GACTCCACAG 
AGCCGCCCTT CGGTCCAGGT GGTCTCTGCA TCCACCTGTC CTGGCACGTC AGGAGCTGCG 
GGCGACCGGA GCAGCAGCAG CAGCAGCCTT CCCTGCCCCG CGCCAAACTC CCGGCCAGCT 
CAAGGTTCAT ACTTTGGAAA CAAAAGAGCT TATGCAGAAA ACACAGTTGC ATCAAATTTT 
ACTTTTGGTG CAAGCTCATC TTCTGCACGA GATACTAATT ATCCTCAAAC ACTTAAAACT 
CCATTGTCTA CTGGAAATCC TCAGAGATCA GGTTATAAGA GCTGGACACC ACAAGTGGGA 
TATTCAGCTT CATCCTCATC TGCGATTTCT GCACACTCCC CATCAGTTAT TGTAGCTGTT 
GTAGAAGGGA GAGGACTTGC CAGAGGTGAA ATAGGAATGG CAAGTATTGA TTTAAAAAAC 
CCCCAAATTA TACTATCCCA GTTTGCAGAC AACACAACAT ATGCAAAGGT GATCACTAAA 
CTTAAAATTT TATCACCTTT GGAAATAATA ATGTCAAATA CTGCTTGTGC TGTGGGGAAT 
TCCACCAAGT TGTTCACTCT GATCACAGAA AATTTCAAGA ATGTTAATTT CACTACTATC 
CAAAGGAAAT ACTTCAATGA AACAAAAGGA TTAGAGTACA TTGAACAGTT ATGCATAGCA 
GAATTCAGCA CTGTCCTAAT GGAGGTTCAG TCCAAGTATT ACTGCCTTGC AGCTGTTGCA 
GCTTTGTTAA AATATGTTGA ATTTATTCAA AATTCAGTTT ATGCACCAAA ATCACTGAAG 
ATTTGTTTCC AGGGTAGTGA ACAGACAGCC ATGATAGATT CATCATCAGC CCAAAACCTT 
GAATTGTTAA TTAATAATCA AGACTATAGG AATAATCACA CTCTCTTTGG TGTTCTAAAT 
TATACTAAGA CTCCTGGAGG GAGTAGACGA CTTCGTTCTA ATATATTAGA GCCTCTAGTT 
GATATTGAAA CCATTAACAT GAGATTAGAT TGTGTTCAAG AACTACTTCA AGATGAGGAA 
CTATTTTTTG GACTTCAATC AGTTATATCA AGATTTCTTG ATACAGAGCA GCTTCTTTCT 
GTTTTAGTCC AAATTCCAAA GCAAGACACG GTCAATGCTG CTGAATCAAA GATAACAAAT 
TTAATATACT TAAAACATAC CTTGGAACTT GTGGATCCTT TAAAGATTGC TATGAAGAAC 
TGTAACACAC CTTTATTAAG AGCTTACTAT GGTTCCTTGG AAGACAAGAG GTTTGGAATC 
ATACTTGAAA AGATTAAAAC AGTAATTAAT GATGATGCAA GATACATGAA AGGATGCCTA 
AACATGAGGA CTCAGAAGTG CTATGCAGTG AGGTCTAACA TAAATGAATT TCTTGACATA 
GCAAGAAGAA CATACACAGA GATTGTAGAT GACATAGCAG GAATGATATC ACAACTTGGA 
GAAAAATATA GTCTACCTTT AAGGACAAGT TTTAGCTCTG CTCGAGGATT TTTCATCCAG 
ATGACTACAG ATTGTATAGC CCTACCTAGT GATCAACTTC CTTCAGAATT TATTAAGATT 
TCTAAAGTGA AAAATTCTTA CAGCTTTACA TCAGCAGATT TAATTAAAAT GAATGAAAGA 
TGCCAAGAAT CTTTGAGAGA AATCTATCAC ATGACTTATA TGATAGTGTG CAAACTGCTT 
AGTGAGATTT ATGAACATAT TCATTGCTTA TATAAACTAT CTGACACTGT GTCAATGCTG 
GATATGCTAC TGTCATTTGC TCATGCCTGC ACTCTTTCTG ACTATGTTCG ACCAGAATTT 
ACTGATACTT TAGCAATCAA ACAGGGATGG CATCCTATTC TTGAAAAAAT ATCTGCGGAA 
AAACCTATTG CCAACAATAC CTATGTTACA GAAGGGAGTA ATTTTTTGAT CATAACTGGA 
CCAAACATGA GTGGAAAATC CACATATTTA AAACAGATTG CTCTTTGTCA GATTATGGCC 
CAGATTGGAT CATATGTTCC AGCAGAATAT TCTTCCTTTA GAATTGCTAA ACAGATTTTT 
ACAAGAATTA GTACTGATGA TGATATCGAA ACAAATTCAT CAACATTTAT GAAAGAAATG 
AAAGAGATAG CATATATTCT ACATAATGCT AATGACAAAT CGCTCATATT AATTGATGAA 
CTTGGCAGAG GTACTAATAC GGAAGAAGGT ATTGGCATTT GTTATGCTGT TTGTGAATAT 
CTACTGAGCT TAAAGGCATT TACACTGTTT GCTACACATT TCCTGGAACT ATGCCATATT 
GATGCCCTGT ATCCTAATGT AGAAAACATG CATTTTGAAG TTCAACATGT AAAGAATACC 
TCAAGAAATA AAGAAGCAAT TTTGTATACC TACAAACTTT CTAAGGGACT CACAGAAGAG 
AAAAATTATG GATTAAAAGC TGCAGAGGTG TCATCACTTC CACCATCAAT TGTCTTGGAT 
GCCAAGGAAA TCACAACTCA AATTACGAGA CAAATTTTGC AAAACCAAAG GAGTACCCCT 
GAGATGGAAA GACAGAGAGC TGTGTACCAT CTAGCCACTA GGCTTGTTCA AACTGCTCGA 
AACTCTCAAT TGGATCCAGA CAGTTTACGA ATATATTTAA GTAACCTCAA GAAGAAGTAC 
AAAGAAGATT TTCCCAGGAC TGAACAAGTT CCAGAAAAGA CTGAAGAATA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002431.2
CDS	105..2915
Translation	MLRPEISSTSPSAPAVSPSSGETRSPQGPRYNFGLQETPQSRPSVQVVSASTCPGTSGAAGDRSSSSSSLPCPAPNSRPAQGSYFGNKRAYAENTVASNFTFGASSSSARDTNYPQTLKTPLSTGNPQRSGYKSWTPQVGYSASSSSAISAHSPSVIVAVVEGRGLARGEIGMASIDLKNPQIILSQFADNTTYAKVITKLKILSPLEIIMSNTACAVGNSTKLFTLITENFKNVNFTTIQRKYFNETKGLEYIEQLCIAEFSTVLMEVQSKYYCLAAVAALLKYVEFIQNSVYAPKSLKICFQGSEQTAMIDSSSAQNLELLINNQDYRNNHTLFGVLNYTKTPGGSRRLRSNILEPLVDIETINMRLDCVQELLQDEELFFGLQSVISRFLDTEQLLSVLVQIPKQDTVNAAESKITNLIYLKHTLELVDPLKIAMKNCNTPLLRAYYGSLEDKRFGIILEKIKTVINDDARYMKGCLNMRTQKCYAVRSNINEFLDIARRTYTEIVDDIAGMISQLGEKYSLPLRTSFSSARGFFIQMTTDCIALPSDQLPSEFIKISKVKNSYSFTSADLIKMNERCQESLREIYHMTYMIVCKLLSEIYEHIHCLYKLSDTVSMLDMLLSFAHACTLSDYVRPEFTDTLAIKQGWHPILEKISAEKPIANNTYVTEGSNFLIITGPNMSGKSTYLKQIALCQIMAQIGSYVPAEYSSFRIAKQIFTRISTDDDIETNSSTFMKEMKEIAYILHNANDKSLILIDELGRGTNTEEGIGICYAVCEYLLSLKAFTLFATHFLELCHIDALYPNVENMHFEVQHVKNTSRNKEAILYTYKLSKGLTEEKNYGLKAAEVSSLPPSIVLDAKEITTQITRQILQNQRSTPEMERQRAVYHLATRLVQTARNSQLDPDSLRIYLSNLKKKYKEDFPRTEQVPEKTEE

Target ORF information:

RefSeq Version	NM_002440.4
Organism	Homo sapiens(human)
Definition	Homo sapiens mutS homolog 4 (MSH4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002440.4

ORF Insert Sequence:

ATGCTGAGGC CTGAGATCTC ATCAACCTCG CCTTCTGCCC CGGCGGTTTC CCCGTCGTCG 
GGAGAAACCC GCTCACCTCA GGGTCCCCGC TACAATTTCG GACTCCAGGA GACTCCACAG 
AGCCGCCCTT CGGTCCAGGT GGTCTCTGCA TCCACCTGTC CTGGCACGTC AGGAGCTGCG 
GGCGACCGGA GCAGCAGCAG CAGCAGCCTT CCCTGCCCCG CGCCAAACTC CCGGCCAGCT 
CAAGGTTCAT ACTTTGGAAA CAAAAGAGCT TATGCAGAAA ACACAGTTGC ATCAAATTTT 
ACTTTTGGTG CAAGCTCATC TTCTGCACGA GATACTAATT ATCCTCAAAC ACTTAAAACT 
CCATTGTCTA CTGGAAATCC TCAGAGATCA GGTTATAAGA GCTGGACACC ACAAGTGGGA 
TATTCAGCTT CATCCTCATC TGCGATTTCT GCACACTCCC CATCAGTTAT TGTAGCTGTT 
GTAGAAGGGA GAGGACTTGC CAGAGGTGAA ATAGGAATGG CAAGTATTGA TTTAAAAAAC 
CCCCAAATTA TACTATCCCA GTTTGCAGAC AACACAACAT ATGCAAAGGT GATCACTAAA 
CTTAAAATTT TATCACCTTT GGAAATAATA ATGTCAAATA CTGCTTGTGC TGTGGGGAAT 
TCCACCAAGT TGTTCACTCT GATCACAGAA AATTTCAAGA ATGTTAATTT CACTACTATC 
CAAAGGAAAT ACTTCAATGA AACAAAAGGA TTAGAGTACA TTGAACAGTT ATGCATAGCA 
GAATTCAGCA CTGTCCTAAT GGAGGTTCAG TCCAAGTATT ACTGCCTTGC AGCTGTTGCA 
GCTTTGTTAA AATATGTTGA ATTTATTCAA AATTCAGTTT ATGCACCAAA ATCACTGAAG 
ATTTGTTTCC AGGGTAGTGA ACAGACAGCC ATGATAGATT CATCATCAGC CCAAAACCTT 
GAATTGTTAA TTAATAATCA AGACTATAGG AATAATCACA CTCTCTTTGG TGTTCTAAAT 
TATACTAAGA CTCCTGGAGG GAGTAGACGA CTTCGTTCTA ATATATTAGA GCCTCTAGTT 
GATATTGAAA CCATTAACAT GAGATTAGAT TGTGTTCAAG AACTACTTCA AGATGAGGAA 
CTATTTTTTG GACTTCAATC AGTTATATCA AGATTTCTTG ATACAGAGCA GCTTCTTTCT 
GTTTTAGTCC AAATTCCAAA GCAAGACACG GTCAATGCTG CTGAATCAAA GATAACAAAT 
TTAATATACT TAAAACATAC CTTGGAACTT GTGGATCCTT TAAAGATTGC TATGAAGAAC 
TGTAACACAC CTTTATTAAG AGCTTACTAT GGTTCCTTGG AAGACAAGAG GTTTGGAATC 
ATACTTGAAA AGATTAAAAC AGTAATTAAT GATGATGCAA GATACATGAA AGGATGCCTA 
AACATGAGGA CTCAGAAGTG CTATGCAGTG AGGTCTAACA TAAATGAATT TCTTGACATA 
GCAAGAAGAA CATACACAGA GATTGTAGAT GACATAGCAG GAATGATATC ACAACTTGGA 
GAAAAATATA GTCTACCTTT AAGGACAAGT TTTAGCTCTG CTCGAGGATT TTTCATCCAG 
ATGACTACAG ATTGTATAGC CCTACCTAGT GATCAACTTC CTTCAGAATT TATTAAGATT 
TCTAAAGTGA AAAATTCTTA CAGCTTTACA TCAGCAGATT TAATTAAAAT GAATGAAAGA 
TGCCAAGAAT CTTTGAGAGA AATCTATCAC ATGACTTATA TGATAGTGTG CAAACTGCTT 
AGTGAGATTT ATGAACATAT TCATTGCTTA TATAAACTAT CTGACACTGT GTCAATGCTG 
GATATGCTAC TGTCATTTGC TCATGCCTGC ACTCTTTCTG ACTATGTTCG ACCAGAATTT 
ACTGATACTT TAGCAATCAA ACAGGGATGG CATCCTATTC TTGAAAAAAT ATCTGCGGAA 
AAACCTATTG CCAACAATAC CTATGTTACA GAAGGGAGTA ATTTTTTGAT CATAACTGGA 
CCAAACATGA GTGGAAAATC CACATATTTA AAACAGATTG CTCTTTGTCA GATTATGGCC 
CAGATTGGAT CATATGTTCC AGCAGAATAT TCTTCCTTTA GAATTGCTAA ACAGATTTTT 
ACAAGAATTA GTACTGATGA TGATATCGAA ACAAATTCAT CAACATTTAT GAAAGAAATG 
AAAGAGATAG CATATATTCT ACATAATGCT AATGACAAAT CGCTCATATT AATTGATGAA 
CTTGGCAGAG GTACTAATAC GGAAGAAGGT ATTGGCATTT GTTATGCTGT TTGTGAATAT 
CTACTGAGCT TAAAGGCATT TACACTGTTT GCTACACATT TCCTGGAACT ATGCCATATT 
GATGCCCTGT ATCCTAATGT AGAAAACATG CATTTTGAAG TTCAACATGT AAAGAATACC 
TCAAGAAATA AAGAAGCAAT TTTGTATACC TACAAACTTT CTAAGGGACT CACAGAAGAG 
AAAAATTATG GATTAAAAGC TGCAGAGGTG TCATCACTTC CACCATCAAT TGTCTTGGAT 
GCCAAGGAAA TCACAACTCA AATTACGAGA CAAATTTTGC AAAACCAAAG GAGTACCCCT 
GAGATGGAAA GACAGAGAGC TGTGTACCAT CTAGCCACTA GGCTTGTTCA AACTGCTCGA 
AACTCTCAAT TGGATCCAGA CAGTTTACGA ATATATTTAA GTAACCTCAA GAAGAAGTAC 
AAAGAAGATT TTCCCAGGAC TGAACAAGTT CCAGAAAAGA CTGAAGAATA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

A homozygous donor splice-site mutation in the meiotic gene MSH4 causes primary ovarian insufficiency.
Human molecular genetics26(16)3161-3166(2017 Aug)
Carlosama C,Elzaiat M,Pati?o LC,Mateus HE,Veitia RA,Laissue P

TP53, MSH4, and LATS1 germline mutations in a family with clustering of nervous system tumors.
The American journal of pathology184(9)2374-81(2014 Sep)
Kim YH,Ohta T,Oh JE,Le Calvez-Kelm F,McKay J,Voegele C,Durand G,Mittelbronn M,Kleihues P,Paulus W,Ohgaki H

DNA damage induced MutS homologue hMSH4 acetylation.
International journal of molecular sciences14(10)20966-82(2013 Oct)
Chu YL,Wu X,Xu J,Watts JL,Her C

MutS homologue hMSH4: interaction with eIF3f and a role in NHEJ-mediated DSB repair.
Molecular cancer1251(2013 Jun)
Chu YL,Wu X,Xu Y,Her C

MutS homologue hMSH5: role in cisplatin-induced DNA damage response.
Molecular cancer1110(2012 Mar)
Tompkins JD,Wu X,Her C