BECN2 cDNA ORF clone, Homo sapiens(human)

Reactive Oxygen Species-Mediated c-Jun NH
Zhong L, Shu W, Dai W, Gao B, Xiong S
Journal of virology91(15)(2017 Aug)

BECN2 interacts with ATG14 through a metastable coiled-coil to mediate autophagy.
Su M, Li Y, Wyborny S, Neau D, Chakravarthy S, Levine B, Colbert CL, Sinha SC
Protein science : a publication of the Protein Society26(5)972-984(2017 May)

Endolysosomal trafficking of viral G protein-coupled receptor functions in innate immunity and control of viral oncogenesis.
Dong X, Cheng A, Zou Z, Yang YS, Sumpter RM Jr, Huang CL, Bhagat G, Virgin HW, Lira SA, Levine B
Proceedings of the National Academy of Sciences of the United States of America113(11)2994-9(2016 Mar)

Expression of Beclin Family Proteins Is Associated with Tumor Progression in Oral Cancer.
Liu JL, Chen FF, Chang SF, Chen CN, Lung J, Lo CH, Lee FH, Lu YC, Hung CH
PloS one10(10)e0141308(2015)

Beclin 2 functions in autophagy, degradation of G protein-coupled receptors, and metabolism.
He C, Wei Y, Sun K, Li B, Dong X, Zou Z, Liu Y, Kinch LN, Khan S, Sinha S, Xavier RJ, Grishin NV, Xiao G, Eskelinen EL, Scherer PE, Whistler JL, Levine B
Cell154(5)1085-99(2013 Aug)

Further data showed that reactive oxygen species-c-Jun activation by HBx resulted in the release of beclin-1 from its association with beclin-2 to form a complex with VPS34, thus enhancing autophagosome formation.
Title: Reactive Oxygen Species-Mediated c-Jun NH

polar BECN2 CCD interface residues result in a metastable homodimer, facilitating dissociation, but enable better interactions with polar ATG14 residues stabilizing the BECN2:ATG14 heterodimer.
Title: BECN2 interacts with ATG14 through a metastable coiled-coil to mediate autophagy.

Both transfected and endogenous beclin 2 coimmunoprecipitated with vGPCR. Beclin 2 overexpression decreased HA-vGPCR steady-state levels. It regulates vGPCR levels by a lysosomal degradation pathway.
Title: Endolysosomal trafficking of viral G protein-coupled receptor functions in innate immunity and control of viral oncogenesis.

distinct patterns of Beclin 1 and Beclin 2 were associated with aggressive clinical outcomes. Beclin 1 overexpression, as well as Beclin 2 overexpression and depletion, contributed to tumor growth.
Title: Expression of Beclin Family Proteins Is Associated with Tumor Progression in Oral Cancer.

Study identified a previously uncharacterized mammalian-specific protein, Beclin 2, which, like Beclin 1, functions in autophagy and interacts with class III PI3K complex components.[Beclin 2]
Title: Beclin 2 functions in autophagy, degradation of G protein-coupled receptors, and metabolism.