BCL2L15 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	BCL2L15
Entrez Gene ID	440603
Full Name	BCL2 like 15
Synonyms	Bfk,C1orf178
General protein information	Preferred Names BCL2 like 15 Names bcl-2-like protein 15 bcl2-L-15 pro-apoptotic Bcl-2 protein
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 1 Map Location: 1p13.2

mRNA and Protein(s)

mRNA	Protein	Name
NM_001010922.3	NP_001010922.1	bcl-2-like protein 15
NM_001010922.2	NP_001010922.1	bcl-2-like protein 15

Pathways from BioSystems

Homologies

Homo sapiens (human)	BCL2L15	NP_001010922.1
	BCL2L15	XP_001110407.1
Pan troglodytes (chimpanzee)	BCL2L15	XP_003949563.1
Bos taurus (cattle)	BCL2L15	NP_001068885.1
Mus musculus (house mouse)	Bcl2l15	NP_001136431.1
Rattus norvegicus (Norway rat)	Bcl2l15	NP_001099929.1
Gallus gallus (chicken)	BCL2L15	XP_001233931.1
Canis lupus familiaris (dog)	BCL2L15	XP_848250.2

Gene Ontology
Bibliography

Related articles in PubMed

Large-scale genotyping identifies 41 new loci associated with breast cancer risk.
Michailidou K, Hall P, Gonzalez-Neira A, Ghoussaini M, Dennis J, Milne RL, Schmidt MK, Chang-Claude J, Bojesen SE, Bolla MK, Wang Q, Dicks E, Lee A, Turnbull C, Rahman N, , Fletcher O, Peto J, Gibson L, Dos Santos Silva I, Nevanlinna H, Muranen TA, Aittom?ki K, Blomqvist C, Czene K, Irwanto A, Liu J, Waisfisz Q, Meijers-Heijboer H, Adank M, , van der Luijt RB, Hein R, Dahmen N, Beckman L, Meindl A, Schmutzler RK, M?ller-Myhsok B, Lichtner P, Hopper JL, Southey MC, Makalic E, Schmidt DF, Uitterlinden AG, Hofman A, Hunter DJ, Chanock SJ, Vincent D, Bacot F, Tessier DC, Canisius S, Wessels LF, Haiman CA, Shah M, Luben R, Brown J, Luccarini C, Schoof N, Humphreys K, Li J, Nordestgaard BG, Nielsen SF, Flyger H, Couch FJ, Wang X, Vachon C, Stevens KN, Lambrechts D, Moisse M, Paridaens R, Christiaens MR, Rudolph A, Nickels S, Flesch-Janys D, Johnson N, Aitken Z, Aaltonen K, Heikkinen T, Broeks A, Veer LJ, van der Schoot CE, Gu?nel P, Truong T, Laurent-Puig P, Menegaux F, Marme F, Schneeweiss A, Sohn C, Burwinkel B, Zamora MP, Perez JI, Pita G, Alonso MR, Cox A, Brock IW, Cross SS, Reed MW, Sawyer EJ, Tomlinson I, Kerin MJ, Miller N, Henderson BE, Schumacher F, Le Marchand L, Andrulis IL, Knight JA, Glendon G, Mulligan AM, , , Lindblom A, Margolin S, Hooning MJ, Hollestelle A, van den Ouweland AM, Jager A, Bui QM, Stone J, Dite GS, Apicella C, Tsimiklis H, Giles GG, Severi G, Baglietto L, Fasching PA, Haeberle L, Ekici AB, Beckmann MW, Brenner H, M?ller H, Arndt V, Stegmaier C, Swerdlow A, Ashworth A, Orr N, Jones M, Figueroa J, Lissowska J, Brinton L, Goldberg MS, Labr?che F, Dumont M, Winqvist R, Pylk?s K, Jukkola-Vuorinen A, Grip M, Brauch H, Hamann U, Br?ning T, , Radice P, Peterlongo P, Manoukian S, Bonanni B, Devilee P, Tollenaar RA, Seynaeve C, van Asperen CJ, Jakubowska A, Lubinski J, Jaworska K, Durda K, Mannermaa A, Kataja V, Kosma VM, Hartikainen JM, Bogdanova NV, Antonenkova NN, D?rk T, Kristensen VN, Anton-Culver H, Slager S, Toland AE, Edge S, Fostira F, Kang D, Yoo KY, Noh DY, Matsuo K, Ito H, Iwata H, Sueta A, Wu AH, Tseng CC, Van Den Berg D, Stram DO, Shu XO, Lu W, Gao YT, Cai H, Teo SH, Yip CH, Phuah SY, Cornes BK, Hartman M, Miao H, Lim WY, Sng JH, Muir K, Lophatananon A, Stewart-Brown S, Siriwanarangsan P, Shen CY, Hsiung CN, Wu PE, Ding SL, Sangrajrang S, Gaborieau V, Brennan P, McKay J, Blot WJ, Signorello LB, Cai Q, Zheng W, Deming-Halverson S, Shrubsole M, Long J, Simard J, Garcia-Closas M, Pharoah PD, Chenevix-Trench G, Dunning AM, Benitez J, Easton DF
Nature genetics45(4)353-61, 361e1-2(2013 Apr)

Bfk, a novel member of the bcl2 gene family, is highly expressed in principal cells of the mouse epididymis and demonstrates a predominant nuclear localization.
Pujianto DA, Damdimopoulos AE, Sipil? P, Jalkanen J, Huhtaniemi I, Poutanen M
Endocrinology148(7)3196-204(2007 Jul)

Differential expression of apoptosis-related proteins in various cellular components of ameloblastomas.
Luo HY, Yu SF, Li TJ
International journal of oral and maxillofacial surgery35(8)750-5(2006 Aug)

Expression of pro-apoptotic Bfk isoforms reduces during malignant transformation in the human gastrointestinal tract.
Dempsey CE, Dive C, Fletcher DJ, Barnes FA, Lobo A, Bingle CD, Whyte MK, Renshaw SA
FEBS letters579(17)3646-50(2005 Jul)

Bfk: a novel weakly proapoptotic member of the Bcl-2 protein family with a BH3 and a BH2 region.
Coultas L, Pellegrini M, Visvader JE, Lindeman GJ, Chen L, Adams JM, Huang DC, Strasser A
Cell death and differentiation10(2)185-92(2003 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

In the transition from normal tissue to tumour, pro-apoptotic Bfk isoform expression is substantially reduced in up to 80% of tumours isolated from the human gastrointestinal tract compared to tumours from outside the gastrointestinal tract.
Title: Expression of pro-apoptotic Bfk isoforms reduces during malignant transformation in the human gastrointestinal tract.

The following BCL2L15 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the BCL2L15 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu16197	NM_001010922.3 Latest version!	Homo sapiens BCL2 like 15 (BCL2L15), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu16197	NM_001010922.2	Homo sapiens BCL2 like 15 (BCL2L15), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

BCL2L15 ( NM_001010922.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_001010922.1 Homo sapiens BCL2 like 15 (BCL2L15), mRNA.

Price & Availability↑

CloneID	OHu16197
Clone ID Related Accession (Same CDS sequence)	NM_001010922.3 , NM_001010922.2
Accession Version	NM_001010922.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 492bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-30
Organism	Homo sapiens(human)
Product	bcl-2-like protein 15
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AL137856.24, AI821052.1, AY265861.1 and BX116361.1. On Nov 22, 2018 this sequence version replaced NM_001010922.2. ##Evidence-Data-START## Transcript exon combination :: AK289439.1, BM829833.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2142586, SAMEA2154405 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000393316.8/ ENSP00000376992.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGAAGAGCT CCCAAACTTT TGAGGAACAA ACGGAATGCA TTGTGAACAC TCTACTCATG 
GACTTCTTGA GCCCAACATT GCAGGTTGCC AGCCGGAACC TATGCTGTGT AGATGAAGTA 
GATTCAGGAG AGCCTTGTTC TTTTGATGTG GCTATCATTG CTGGTCGCCT TCGGATGTTG 
GGTGACCAGT TCAACGGAGA ATTGGAAGCT TCTGCCAAAA ACGTCATTGC AGAAACCATT 
AAGGGACAGA CAGGAGCTAT ACTCCAGGAC ACTGTGGAAT CTCTCAGCAA GACCTGGTGT 
GCTCAGGATT CCAGCTTAGC TTATGAGAGA GCTTTTCTGG CAGTGTCAGT GAAACTTCTT 
GAGTACATGG CTCACATTGC TCCTGAAGTA GTGGGACAGG TGGCTATCCC CATGACGGGT 
ATGATCAATG GGAACCAAGC CATCCGGGAG TTCATCCAGG GCCAGGGAGG TTGGGAAAAT 
CTGGAGAGCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001010922.1
CDS	207..698
Translation	MKSSQTFEEQTECIVNTLLMDFLSPTLQVASRNLCCVDEVDSGEPCSFDVAIIAGRLRMLGDQFNGELEASAKNVIAETIKGQTGAILQDTVESLSKTWCAQDSSLAYERAFLAVSVKLLEYMAHIAPEVVGQVAIPMTGMINGNQAIREFIQGQGGWENLES

Target ORF information:

RefSeq Version	NM_001010922.3
Organism	Homo sapiens(human)
Definition	Homo sapiens BCL2 like 15 (BCL2L15), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001010922.3

ORF Insert Sequence:

ATGAAGAGCT CCCAAACTTT TGAGGAACAA ACGGAATGCA TTGTGAACAC TCTACTCATG 
GACTTCTTGA GCCCAACATT GCAGGTTGCC AGCCGGAACC TATGCTGTGT AGATGAAGTA 
GATTCAGGAG AGCCTTGTTC TTTTGATGTG GCTATCATTG CTGGTCGCCT TCGGATGTTG 
GGTGACCAGT TCAACGGAGA ATTGGAAGCT TCTGCCAAAA ACGTCATTGC AGAAACCATT 
AAGGGACAGA CAGGAGCTAT ACTCCAGGAC ACTGTGGAAT CTCTCAGCAA GACCTGGTGT 
GCTCAGGATT CCAGCTTAGC TTATGAGAGA GCTTTTCTGG CAGTGTCAGT GAAACTTCTT 
GAGTACATGG CTCACATTGC TCCTGAAGTA GTGGGACAGG TGGCTATCCC CATGACGGGT 
ATGATCAATG GGAACCAAGC CATCCGGGAG TTCATCCAGG GCCAGGGAGG TTGGGAAAAT 
CTGGAGAGCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

BCL2L15 ( NM_001010922.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001010922.1 Homo sapiens BCL2 like 15 (BCL2L15), mRNA.

Price & Availability↑

CloneID	OHu16197
Clone ID Related Accession (Same CDS sequence)	NM_001010922.3 , NM_001010922.2
Accession Version	NM_001010922.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 492bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	bcl-2-like protein 15
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AI821052.1, AY265861.1, AL137856.24 and BX116361.1. On Jan 12, 2007 this sequence version replaced NM_001010922.1. ##Evidence-Data-START## Transcript exon combination :: AK289439.1, BM829833.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2142586, SAMEA2154405 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAAGAGCT CCCAAACTTT TGAGGAACAA ACGGAATGCA TTGTGAACAC TCTACTCATG 
GACTTCTTGA GCCCAACATT GCAGGTTGCC AGCCGGAACC TATGCTGTGT AGATGAAGTA 
GATTCAGGAG AGCCTTGTTC TTTTGATGTG GCTATCATTG CTGGTCGCCT TCGGATGTTG 
GGTGACCAGT TCAACGGAGA ATTGGAAGCT TCTGCCAAAA ACGTCATTGC AGAAACCATT 
AAGGGACAGA CAGGAGCTAT ACTCCAGGAC ACTGTGGAAT CTCTCAGCAA GACCTGGTGT 
GCTCAGGATT CCAGCTTAGC TTATGAGAGA GCTTTTCTGG CAGTGTCAGT GAAACTTCTT 
GAGTACATGG CTCACATTGC TCCTGAAGTA GTGGGACAGG TGGCTATCCC CATGACGGGT 
ATGATCAATG GGAACCAAGC CATCCGGGAG TTCATCCAGG GCCAGGGAGG TTGGGAAAAT 
CTGGAGAGCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001010922.1
CDS	173..664
Translation	MKSSQTFEEQTECIVNTLLMDFLSPTLQVASRNLCCVDEVDSGEPCSFDVAIIAGRLRMLGDQFNGELEASAKNVIAETIKGQTGAILQDTVESLSKTWCAQDSSLAYERAFLAVSVKLLEYMAHIAPEVVGQVAIPMTGMINGNQAIREFIQGQGGWENLES

Target ORF information:

RefSeq Version	NM_001010922.2
Organism	Homo sapiens(human)
Definition	Homo sapiens BCL2 like 15 (BCL2L15), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001010922.2

ORF Insert Sequence:

ATGAAGAGCT CCCAAACTTT TGAGGAACAA ACGGAATGCA TTGTGAACAC TCTACTCATG 
GACTTCTTGA GCCCAACATT GCAGGTTGCC AGCCGGAACC TATGCTGTGT AGATGAAGTA 
GATTCAGGAG AGCCTTGTTC TTTTGATGTG GCTATCATTG CTGGTCGCCT TCGGATGTTG 
GGTGACCAGT TCAACGGAGA ATTGGAAGCT TCTGCCAAAA ACGTCATTGC AGAAACCATT 
AAGGGACAGA CAGGAGCTAT ACTCCAGGAC ACTGTGGAAT CTCTCAGCAA GACCTGGTGT 
GCTCAGGATT CCAGCTTAGC TTATGAGAGA GCTTTTCTGG CAGTGTCAGT GAAACTTCTT 
GAGTACATGG CTCACATTGC TCCTGAAGTA GTGGGACAGG TGGCTATCCC CATGACGGGT 
ATGATCAATG GGAACCAAGC CATCCGGGAG TTCATCCAGG GCCAGGGAGG TTGGGAAAAT 
CTGGAGAGCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Large-scale genotyping identifies 41 new loci associated with breast cancer risk.
Nature genetics45(4)353-61, 361e1-2(2013 Apr)
Michailidou K,Hall P,Gonzalez-Neira A,Ghoussaini M,Dennis J,Milne RL,Schmidt MK,Chang-Claude J,Bojesen SE,Bolla MK,Wang Q,Dicks E,Lee A,Turnbull C,Rahman N,,Fletcher O,Peto J,Gibson L,Dos Santos Silva I,Nevanlinna H,Muranen TA,Aittom?ki K,Blomqvist C,Czene K,Irwanto A,Liu J,Waisfisz Q,Meijers-Heijboer H,Adank M,,van der Luijt RB,Hein R,Dahmen N,Beckman L,Meindl A,Schmutzler RK,M?ller-Myhsok B,Lichtner P,Hopper JL,Southey MC,Makalic E,Schmidt DF,Uitterlinden AG,Hofman A,Hunter DJ,Chanock SJ,Vincent D,Bacot F,Tessier DC,Canisius S,Wessels LF,Haiman CA,Shah M,Luben R,Brown J,Luccarini C,Schoof N,Humphreys K,Li J,Nordestgaard BG,Nielsen SF,Flyger H,Couch FJ,Wang X,Vachon C,Stevens KN,Lambrechts D,Moisse M,Paridaens R,Christiaens MR,Rudolph A,Nickels S,Flesch-Janys D,Johnson N,Aitken Z,Aaltonen K,Heikkinen T,Broeks A,Veer LJ,van der Schoot CE,Gu?nel P,Truong T,Laurent-Puig P,Menegaux F,Marme F,Schneeweiss A,Sohn C,Burwinkel B,Zamora MP,Perez JI,Pita G,Alonso MR,Cox A,Brock IW,Cross SS,Reed MW,Sawyer EJ,Tomlinson I,Kerin MJ,Miller N,Henderson BE,Schumacher F,Le Marchand L,Andrulis IL,Knight JA,Glendon G,Mulligan AM,,,Lindblom A,Margolin S,Hooning MJ,Hollestelle A,van den Ouweland AM,Jager A,Bui QM,Stone J,Dite GS,Apicella C,Tsimiklis H,Giles GG,Severi G,Baglietto L,Fasching PA,Haeberle L,Ekici AB,Beckmann MW,Brenner H,M?ller H,Arndt V,Stegmaier C,Swerdlow A,Ashworth A,Orr N,Jones M,Figueroa J,Lissowska J,Brinton L,Goldberg MS,Labr?che F,Dumont M,Winqvist R,Pylk?s K,Jukkola-Vuorinen A,Grip M,Brauch H,Hamann U,Br?ning T,,Radice P,Peterlongo P,Manoukian S,Bonanni B,Devilee P,Tollenaar RA,Seynaeve C,van Asperen CJ,Jakubowska A,Lubinski J,Jaworska K,Durda K,Mannermaa A,Kataja V,Kosma VM,Hartikainen JM,Bogdanova NV,Antonenkova NN,D?rk T,Kristensen VN,Anton-Culver H,Slager S,Toland AE,Edge S,Fostira F,Kang D,Yoo KY,Noh DY,Matsuo K,Ito H,Iwata H,Sueta A,Wu AH,Tseng CC,Van Den Berg D,Stram DO,Shu XO,Lu W,Gao YT,Cai H,Teo SH,Yip CH,Phuah SY,Cornes BK,Hartman M,Miao H,Lim WY,Sng JH,Muir K,Lophatananon A,Stewart-Brown S,Siriwanarangsan P,Shen CY,Hsiung CN,Wu PE,Ding SL,Sangrajrang S,Gaborieau V,Brennan P,McKay J,Blot WJ,Signorello LB,Cai Q,Zheng W,Deming-Halverson S,Shrubsole M,Long J,Simard J,Garcia-Closas M,Pharoah PD,Chenevix-Trench G,Dunning AM,Benitez J,Easton DF

Bfk, a novel member of the bcl2 gene family, is highly expressed in principal cells of the mouse epididymis and demonstrates a predominant nuclear localization.
Endocrinology148(7)3196-204(2007 Jul)
Pujianto DA,Damdimopoulos AE,Sipil? P,Jalkanen J,Huhtaniemi I,Poutanen M

Differential expression of apoptosis-related proteins in various cellular components of ameloblastomas.
International journal of oral and maxillofacial surgery35(8)750-5(2006 Aug)
Luo HY,Yu SF,Li TJ

Expression of pro-apoptotic Bfk isoforms reduces during malignant transformation in the human gastrointestinal tract.
FEBS letters579(17)3646-50(2005 Jul)
Dempsey CE,Dive C,Fletcher DJ,Barnes FA,Lobo A,Bingle CD,Whyte MK,Renshaw SA

Bfk: a novel weakly proapoptotic member of the Bcl-2 protein family with a BH3 and a BH2 region.
Cell death and differentiation10(2)185-92(2003 Feb)
Coultas L,Pellegrini M,Visvader JE,Lindeman GJ,Chen L,Adams JM,Huang DC,Strasser A