MAN2A1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	MAN2A1
Entrez Gene ID	4124
Full Name	mannosidase alpha class 2A member 1
Synonyms	AMan II,GOLIM7,MANA2,MANII
General protein information	Preferred Names mannosidase alpha class 2A member 1 Names alpha-mannosidase 2 Golgi alpha-mannosidase II golgi integral membrane protein 7 mannosidase, alpha type II mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 5 Map Location: 5q21.3
Summary	This gene encodes a glycosyl hydrolase that localizes to the Golgi and catalyzes the final hydrolytic step in the asparagine-linked oligosaccharide (N-glycan) maturation pathway. Mutations in the mouse homolog of this gene have been shown to cause a systemic autoimmune disease similar to human systemic lupus erythematosus. [provided by RefSeq, Dec 2013].
Disorder MIM:	154582

mRNA and Protein(s)

mRNA	Protein	Name
NM_002372.3	NP_002363.2	alpha-mannosidase 2
XM_011543395.2	XP_011541697.1	alpha-mannosidase 2 isoform X2
XM_017009472.1	XP_016864961.1	alpha-mannosidase 2 isoform X1
XM_024446048.1	XP_024301816.1	alpha-mannosidase 2 isoform X2
XM_011543395.3	XP_011541697.1	alpha-mannosidase 2 isoform X3

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	MAN2A1	XP_517864.2
Canis lupus familiaris (dog)	MAN2A1	XP_545995.3
Rattus norvegicus (Norway rat)	Man2a1	NP_037111.2
Xenopus tropicalis (tropical clawed frog)	man2a1	NP_001163963.1
Homo sapiens (human)	MAN2A1	NP_002363.2
Gallus gallus (chicken)	MAN2A1	XP_003643094.1
	MAN2A1	XP_002804520.1
Bos taurus (cattle)	MAN2A1	NP_001192815.1
Mus musculus (house mouse)	Man2a1	NP_032575.2

Gene Ontology
Bibliography

Related articles in PubMed

MAN2A1-FER Fusion Gene Is Expressed by Human Liver and Other Tumor Types and Has Oncogenic Activity in Mice.
Chen ZH, Yu YP, Tao J, Liu S, Tseng G, Nalesnik M, Hamilton R, Bhargava R, Nelson JB, Pennathur A, Monga SP, Luketich JD, Michalopoulos GK, Luo JH
Gastroenterology153(4)1120-1132.e15(2017 Oct)

Using DFT methodology for more reliable predictive models: Design of inhibitors of Golgi ?-Mannosidase II.
Bobovsk? A, Tvaro?ka I, K??a J
Journal of molecular graphics & modelling6647-57(2016 May)

Biological insights from 108 schizophrenia-associated genetic loci.

Nature511(7510)421-7(2014 Jul)

C4orf41 and TTC-15 are mammalian TRAPP components with a role at an early stage in ER-to-Golgi trafficking.
Scrivens PJ, Noueihed B, Shahrzad N, Hul S, Brunet S, Sacher M
Molecular biology of the cell22(12)2083-93(2011 Jun)

Variants in KCNQ1, AP3S1, MAN2A1, and ALDH7A1 and the risk of type 2 diabetes in the Chinese Northern Han population: a case-control study and meta-analysis.
Zhou JB, Yang JK, Zhao L, Xin Z
Medical science monitor : international medical journal of experimental and clinical research16(6)BR179-83(2010 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Many human tumor types and cancer cell lines express the MAN2A1-FER fusion, which increases proliferation and invasiveness of cancer cell lines and has liver oncogenic activity in mice.
Title: MAN2A1-FER Fusion Gene Is Expressed by Human Liver and Other Tumor Types and Has Oncogenic Activity in Mice.

he QSAR models with the fragmented QM-DFT descriptors may find a useful application in structure-based drug design where pure empirical and force field methods reached their limits and where quantum mechanics effects are critical for ligand-receptor interactions. The optimized models will apply in lead optimization processes for GMII drug developments.
Title: Using DFT methodology for more reliable predictive models: Design of inhibitors of Golgi ?-Mannosidase II.

Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
Title: Genome-wide association study of childhood acute lymphoblastic leukemia in Korea.

Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.

Observational study and meta-analysis of gene-disease association. (HuGE Navigator)
Title: Variants in KCNQ1, AP3S1, MAN2A1, and ALDH7A1 and the risk of type 2 diabetes in the Chinese Northern Han population: a case-control study and meta-analysis.

The following MAN2A1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MAN2A1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu58846	XM_011543395.3 Latest version!	Homo sapiens mannosidase alpha class 2A member 1 (MAN2A1), transcript variant X3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$475.30 $679.00
OHu105666	XM_024446048.1 Latest version!	Homo sapiens mannosidase alpha class 2A member 1 (MAN2A1), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$475.30 $679.00
OHu10839	NM_002372.3 Latest version!	Homo sapiens mannosidase alpha class 2A member 1 (MAN2A1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	20	$559.30 $799.00
OHu58845	XM_017009472.1 Latest version!	Homo sapiens mannosidase alpha class 2A member 1 (MAN2A1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	20	$559.30 $799.00
View Old Accession Versions >>
OHu58846	XM_011543395.2	Homo sapiens mannosidase alpha class 2A member 1 (MAN2A1), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$475.30 $679.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

MAN2A1 ( XM_011543395.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_011541697.1 Homo sapiens mannosidase alpha class 2A member 1 (MAN2A1), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OHu58846
Clone ID Related Accession (Same CDS sequence)	XM_011543395.2 , XM_011543395.3
Accession Version	XM_011543395.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2655bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-05
Organism	Homo sapiens(human)
Product	alpha-mannosidase 2 isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000005.10) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011543395.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAAGTTAA GCCGCCAGTT CACCGTGTTC GGCAGTGCGA TCTTCTGTGT GGTGATTTTC 
TCGCTCTACC TGATGCTGGA CCGGGGTCAC TTAGACTACC CCAGGAACCC GCGCCGCGAG 
GGCTCCTTCC CTCAGGGCCA GCTCTCAATG TTGCAAGAAA AAATAGACCA TTTGGAGCGT 
TTGCTAGCTG AGAATAATGA GATCATCTCA AATATTAGAG ACTCAGTCAT CAATTTGAGT 
GAGTCTGTGG AGGATGGTCC GAAAAGTTCA CAAAGCAATT TCAGCCAAGG TGCTGGCTCA 
CATCTTCTGC CCTCACAATT ATCCCTCTCA GTTGACACTG CAGACTGTCT GTTTGCTTCA 
CAAAGTGGAA GTCACAATTC AGATGTGCAG ATGTTGGATG TTTACAGTCT AATTTCTTTT 
GACAATCCAG ATGGTGGAGT TTGGAAGCAA GGATTTGACA TTACTTATGA ATCTAATGAA 
TGGGACACTG AACCCCTTCA AGTCTTTGTG GTGCCTCATT CCCATAACGA CCCAGGTTGG 
TTGAAGACTT TCAATGACTA CTTTAGAGAC AAGACTCAGT ATATTTTTAA TAACATGGTC 
CTAAAGCTGA AAGAAGACTC ACGGAGGAAG TTTATTTGGT CTGAGATCTC TTACCTTTCA 
AAGTGGTGGG ATATTATAGA TATTCAGAAG AAGGATGCTG TTAAAAGTTT AATAGAAAAT 
GGTCAGCTTG AAATTGTGAC AGGTGGCTGG GTTATGCCTG ATGAAGCTAC TCCACATTAT 
TTTGCCTTAA TTGATCAACT AATTGAAGGA CATCAGTGGC TGGAAAATAA TATAGGAGTG 
AAACCTCGGT CCGGCTGGGC TATTGATCCC TTTGGACACT CACCAACAAT GGCTTATCTT 
CTAAACCGTG CTGGACTTTC TCACATGCTT ATCCAGAGAG TTCATTATGC AGTTAAAAAA 
CACTTTGCAC TGCATAAAAC ATTGGAGTTT TTTTGGAGAC AGAATTGGGA TCTGGGATCT 
GTCACAGATA TTTTATGCCA CATGATGCCC TTCTACAGCT ATGACATCCC TCACACTTGT 
GGACCTGATC CTAAAATATG CTGCCAGTTT GATTTTAAAC GTCTTCCTGG AGGCAGATTT 
GGTTGTCCCT GGGGAGTCCC CCCAGAAACA ATACATCCTG GAAATGTCCA AAGCAGGGCT 
CGGATGCTAC TAGATCAGTA CCGAAAGAAG TCAAAGCTTT TTCGTACCAA AGTTCTCCTG 
GCTCCACTAG GAGATGATTT CCGCTACTGT GAATACACGG AATGGGATTT ACAGTTTAAG 
AATTATCAGC AGCTTTTTGA TTATATGAAT TCTCAGTCCA AGTTTAAAGT TAAGATACAG 
TTTGGAACTT TATCAGATTT TTTTGATGCG CTGGATAAAG CAGATGAAAC TCAGAGAGAC 
AAGGGCCAAT CGATGTTCCC TGTTTTAAGT GGAGATTTTT TCACTTATGC CGATCGAGAT 
GATCATTACT GGAGTGGCTA TTTTACATCC AGACCCTTTT ACAAACGAAT GGACAGAATC 
ATGGAATCTC ATTTAAGGGC TGCTGAAATT CTTTACTATT TCGCCCTGAG ACAAGCTCAC 
AAATACAAGA TAAATAAATT TCTCTCATCA TCACTTTACA CGGCACTGAC AGAAGCCAGA 
AGGAATTTGG GACTGTTTCA ACATCATGAT GCTATCACAG GAACTGCAAA AGACTGGGTG 
GTTGTGGATT ATGGTACCAG ACTTTTTCAT TCGTTAATGG TTTTGGAGAA GATAATTGGA 
AATTCTGCAT TTCTTCTTAT TTTGAAGGAC AAACTCACAT ACGACTCTTA CTCTCCTGAT 
ACCTTCCTGG AGATGGATTT GAAACAAAAA TCACAAGATT CTCTGCCACA AAAAAATATA 
ATAAGGCTGA GTGCGGAGCC AAGGTACCTT GTGGTCTATA ATCCTTTAGA ACAAGACCGA 
ATCTCGTTGG TCTCAGTCTA TGTGAGTTCC CCGACAGTGC AAGTGTTCTC TGCTTCAGGA 
AAACCTGTGG AAGTTCAAGT CAGCGCAGTT TGGGATACAG CAAATACTAT TTCAGAAACA 
GCCTATGAGA TCTCTTTTCG AGCACATATA CCGCCATTGG GACTGAAAGT GTATAAGATT 
TTGGAATCAG CAAGTTCAAA TTCACATTTA GCTGATTATG TCTTGTATAA GAATAAAGTA 
GAAGATAGCG GAATTTTCAC CATAAAGAAT ATGATAAATA CTGAAGAAGG TATAACACTA 
GAGAACTCCT TTGTTTTACT TCGGTTTGAT CAAACTGGAC TTATGAAGCA AATGATGACT 
AAAGAAGATG GTAAACACCA TGAAGTAAAT GTGCAATTTT CATGGTATGG AACCACAATT 
AAAAGAGACA AAAGTGGTGC CTACCTCTTC TTACCTGATG GTAATGCCAA GCCTTATGTT 
TACACAACAC CGCCCTTTGT CAGAGTGACA CATGGAAGGA TTTATTCGGA AGTGACTTGC 
TTTTTTGACC ATGTTACTCA TAGAGTCCGA CTATACCACA TACAGGGCAT GAAAGAGAAG 
GTTATTTTAA GGGACTGCAA GCACATTCTG GTTACACAGA TTCAGAACTC AGAGGTTATC 
TTTGGGGCTG TTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011541697.1
CDS	492..3146
Translation	MKLSRQFTVFGSAIFCVVIFSLYLMLDRGHLDYPRNPRREGSFPQGQLSMLQEKIDHLERLLAENNEIISNIRDSVINLSESVEDGPKSSQSNFSQGAGSHLLPSQLSLSVDTADCLFASQSGSHNSDVQMLDVYSLISFDNPDGGVWKQGFDITYESNEWDTEPLQVFVVPHSHNDPGWLKTFNDYFRDKTQYIFNNMVLKLKEDSRRKFIWSEISYLSKWWDIIDIQKKDAVKSLIENGQLEIVTGGWVMPDEATPHYFALIDQLIEGHQWLENNIGVKPRSGWAIDPFGHSPTMAYLLNRAGLSHMLIQRVHYAVKKHFALHKTLEFFWRQNWDLGSVTDILCHMMPFYSYDIPHTCGPDPKICCQFDFKRLPGGRFGCPWGVPPETIHPGNVQSRARMLLDQYRKKSKLFRTKVLLAPLGDDFRYCEYTEWDLQFKNYQQLFDYMNSQSKFKVKIQFGTLSDFFDALDKADETQRDKGQSMFPVLSGDFFTYADRDDHYWSGYFTSRPFYKRMDRIMESHLRAAEILYYFALRQAHKYKINKFLSSSLYTALTEARRNLGLFQHHDAITGTAKDWVVVDYGTRLFHSLMVLEKIIGNSAFLLILKDKLTYDSYSPDTFLEMDLKQKSQDSLPQKNIIRLSAEPRYLVVYNPLEQDRISLVSVYVSSPTVQVFSASGKPVEVQVSAVWDTANTISETAYEISFRAHIPPLGLKVYKILESASSNSHLADYVLYKNKVEDSGIFTIKNMINTEEGITLENSFVLLRFDQTGLMKQMMTKEDGKHHEVNVQFSWYGTTIKRDKSGAYLFLPDGNAKPYVYTTPPFVRVTHGRIYSEVTCFFDHVTHRVRLYHIQGMKEKVILRDCKHILVTQIQNSEVIFGAV

Target ORF information:

RefSeq Version	XM_011543395.2
Organism	Homo sapiens(human)
Definition	Homo sapiens mannosidase alpha class 2A member 1 (MAN2A1), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011543395.2

ORF Insert Sequence:

ATGAAGTTAA GCCGCCAGTT CACCGTGTTC GGCAGTGCGA TCTTCTGTGT GGTGATTTTC 
TCGCTCTACC TGATGCTGGA CCGGGGTCAC TTAGACTACC CCAGGAACCC GCGCCGCGAG 
GGCTCCTTCC CTCAGGGCCA GCTCTCAATG TTGCAAGAAA AAATAGACCA TTTGGAGCGT 
TTGCTAGCTG AGAATAATGA GATCATCTCA AATATTAGAG ACTCAGTCAT CAATTTGAGT 
GAGTCTGTGG AGGATGGTCC GAAAAGTTCA CAAAGCAATT TCAGCCAAGG TGCTGGCTCA 
CATCTTCTGC CCTCACAATT ATCCCTCTCA GTTGACACTG CAGACTGTCT GTTTGCTTCA 
CAAAGTGGAA GTCACAATTC AGATGTGCAG ATGTTGGATG TTTACAGTCT AATTTCTTTT 
GACAATCCAG ATGGTGGAGT TTGGAAGCAA GGATTTGACA TTACTTATGA ATCTAATGAA 
TGGGACACTG AACCCCTTCA AGTCTTTGTG GTGCCTCATT CCCATAACGA CCCAGGTTGG 
TTGAAGACTT TCAATGACTA CTTTAGAGAC AAGACTCAGT ATATTTTTAA TAACATGGTC 
CTAAAGCTGA AAGAAGACTC ACGGAGGAAG TTTATTTGGT CTGAGATCTC TTACCTTTCA 
AAGTGGTGGG ATATTATAGA TATTCAGAAG AAGGATGCTG TTAAAAGTTT AATAGAAAAT 
GGTCAGCTTG AAATTGTGAC AGGTGGCTGG GTTATGCCTG ATGAAGCTAC TCCACATTAT 
TTTGCCTTAA TTGATCAACT AATTGAAGGA CATCAGTGGC TGGAAAATAA TATAGGAGTG 
AAACCTCGGT CCGGCTGGGC TATTGATCCC TTTGGACACT CACCAACAAT GGCTTATCTT 
CTAAACCGTG CTGGACTTTC TCACATGCTT ATCCAGAGAG TTCATTATGC AGTTAAAAAA 
CACTTTGCAC TGCATAAAAC ATTGGAGTTT TTTTGGAGAC AGAATTGGGA TCTGGGATCT 
GTCACAGATA TTTTATGCCA CATGATGCCC TTCTACAGCT ATGACATCCC TCACACTTGT 
GGACCTGATC CTAAAATATG CTGCCAGTTT GATTTTAAAC GTCTTCCTGG AGGCAGATTT 
GGTTGTCCCT GGGGAGTCCC CCCAGAAACA ATACATCCTG GAAATGTCCA AAGCAGGGCT 
CGGATGCTAC TAGATCAGTA CCGAAAGAAG TCAAAGCTTT TTCGTACCAA AGTTCTCCTG 
GCTCCACTAG GAGATGATTT CCGCTACTGT GAATACACGG AATGGGATTT ACAGTTTAAG 
AATTATCAGC AGCTTTTTGA TTATATGAAT TCTCAGTCCA AGTTTAAAGT TAAGATACAG 
TTTGGAACTT TATCAGATTT TTTTGATGCG CTGGATAAAG CAGATGAAAC TCAGAGAGAC 
AAGGGCCAAT CGATGTTCCC TGTTTTAAGT GGAGATTTTT TCACTTATGC CGATCGAGAT 
GATCATTACT GGAGTGGCTA TTTTACATCC AGACCCTTTT ACAAACGAAT GGACAGAATC 
ATGGAATCTC ATTTAAGGGC TGCTGAAATT CTTTACTATT TCGCCCTGAG ACAAGCTCAC 
AAATACAAGA TAAATAAATT TCTCTCATCA TCACTTTACA CGGCACTGAC AGAAGCCAGA 
AGGAATTTGG GACTGTTTCA ACATCATGAT GCTATCACAG GAACTGCAAA AGACTGGGTG 
GTTGTGGATT ATGGTACCAG ACTTTTTCAT TCGTTAATGG TTTTGGAGAA GATAATTGGA 
AATTCTGCAT TTCTTCTTAT TTTGAAGGAC AAACTCACAT ACGACTCTTA CTCTCCTGAT 
ACCTTCCTGG AGATGGATTT GAAACAAAAA TCACAAGATT CTCTGCCACA AAAAAATATA 
ATAAGGCTGA GTGCGGAGCC AAGGTACCTT GTGGTCTATA ATCCTTTAGA ACAAGACCGA 
ATCTCGTTGG TCTCAGTCTA TGTGAGTTCC CCGACAGTGC AAGTGTTCTC TGCTTCAGGA 
AAACCTGTGG AAGTTCAAGT CAGCGCAGTT TGGGATACAG CAAATACTAT TTCAGAAACA 
GCCTATGAGA TCTCTTTTCG AGCACATATA CCGCCATTGG GACTGAAAGT GTATAAGATT 
TTGGAATCAG CAAGTTCAAA TTCACATTTA GCTGATTATG TCTTGTATAA GAATAAAGTA 
GAAGATAGCG GAATTTTCAC CATAAAGAAT ATGATAAATA CTGAAGAAGG TATAACACTA 
GAGAACTCCT TTGTTTTACT TCGGTTTGAT CAAACTGGAC TTATGAAGCA AATGATGACT 
AAAGAAGATG GTAAACACCA TGAAGTAAAT GTGCAATTTT CATGGTATGG AACCACAATT 
AAAAGAGACA AAAGTGGTGC CTACCTCTTC TTACCTGATG GTAATGCCAA GCCTTATGTT 
TACACAACAC CGCCCTTTGT CAGAGTGACA CATGGAAGGA TTTATTCGGA AGTGACTTGC 
TTTTTTGACC ATGTTACTCA TAGAGTCCGA CTATACCACA TACAGGGCAT GAAAGAGAAG 
GTTATTTTAA GGGACTGCAA GCACATTCTG GTTACACAGA TTCAGAACTC AGAGGTTATC 
TTTGGGGCTG TTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MAN2A1 ( XM_011543395.3 ) cDNA ORF clone, Homo sapiens(human) -> XP_011541697.1 Homo sapiens mannosidase alpha class 2A member 1 (MAN2A1), transcript variant X3, mRNA.

Price & Availability↑

CloneID	OHu58846
Clone ID Related Accession (Same CDS sequence)	XM_011543395.2 , XM_011543395.3
Accession Version	XM_011543395.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2655bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	alpha-mannosidase 2 isoform X3
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000005.10) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_011543395.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAAGTTAA GCCGCCAGTT CACCGTGTTC GGCAGTGCGA TCTTCTGTGT GGTGATTTTC 
TCGCTCTACC TGATGCTGGA CCGGGGTCAC TTAGACTACC CCAGGAACCC GCGCCGCGAG 
GGCTCCTTCC CTCAGGGCCA GCTCTCAATG TTGCAAGAAA AAATAGACCA TTTGGAGCGT 
TTGCTAGCTG AGAATAATGA GATCATCTCA AATATTAGAG ACTCAGTCAT CAATTTGAGT 
GAGTCTGTGG AGGATGGTCC GAAAAGTTCA CAAAGCAATT TCAGCCAAGG TGCTGGCTCA 
CATCTTCTGC CCTCACAATT ATCCCTCTCA GTTGACACTG CAGACTGTCT GTTTGCTTCA 
CAAAGTGGAA GTCACAATTC AGATGTGCAG ATGTTGGATG TTTACAGTCT AATTTCTTTT 
GACAATCCAG ATGGTGGAGT TTGGAAGCAA GGATTTGACA TTACTTATGA ATCTAATGAA 
TGGGACACTG AACCCCTTCA AGTCTTTGTG GTGCCTCATT CCCATAACGA CCCAGGTTGG 
TTGAAGACTT TCAATGACTA CTTTAGAGAC AAGACTCAGT ATATTTTTAA TAACATGGTC 
CTAAAGCTGA AAGAAGACTC ACGGAGGAAG TTTATTTGGT CTGAGATCTC TTACCTTTCA 
AAGTGGTGGG ATATTATAGA TATTCAGAAG AAGGATGCTG TTAAAAGTTT AATAGAAAAT 
GGTCAGCTTG AAATTGTGAC AGGTGGCTGG GTTATGCCTG ATGAAGCTAC TCCACATTAT 
TTTGCCTTAA TTGATCAACT AATTGAAGGA CATCAGTGGC TGGAAAATAA TATAGGAGTG 
AAACCTCGGT CCGGCTGGGC TATTGATCCC TTTGGACACT CACCAACAAT GGCTTATCTT 
CTAAACCGTG CTGGACTTTC TCACATGCTT ATCCAGAGAG TTCATTATGC AGTTAAAAAA 
CACTTTGCAC TGCATAAAAC ATTGGAGTTT TTTTGGAGAC AGAATTGGGA TCTGGGATCT 
GTCACAGATA TTTTATGCCA CATGATGCCC TTCTACAGCT ATGACATCCC TCACACTTGT 
GGACCTGATC CTAAAATATG CTGCCAGTTT GATTTTAAAC GTCTTCCTGG AGGCAGATTT 
GGTTGTCCCT GGGGAGTCCC CCCAGAAACA ATACATCCTG GAAATGTCCA AAGCAGGGCT 
CGGATGCTAC TAGATCAGTA CCGAAAGAAG TCAAAGCTTT TTCGTACCAA AGTTCTCCTG 
GCTCCACTAG GAGATGATTT CCGCTACTGT GAATACACGG AATGGGATTT ACAGTTTAAG 
AATTATCAGC AGCTTTTTGA TTATATGAAT TCTCAGTCCA AGTTTAAAGT TAAGATACAG 
TTTGGAACTT TATCAGATTT TTTTGATGCG CTGGATAAAG CAGATGAAAC TCAGAGAGAC 
AAGGGCCAAT CGATGTTCCC TGTTTTAAGT GGAGATTTTT TCACTTATGC CGATCGAGAT 
GATCATTACT GGAGTGGCTA TTTTACATCC AGACCCTTTT ACAAACGAAT GGACAGAATC 
ATGGAATCTC ATTTAAGGGC TGCTGAAATT CTTTACTATT TCGCCCTGAG ACAAGCTCAC 
AAATACAAGA TAAATAAATT TCTCTCATCA TCACTTTACA CGGCACTGAC AGAAGCCAGA 
AGGAATTTGG GACTGTTTCA ACATCATGAT GCTATCACAG GAACTGCAAA AGACTGGGTG 
GTTGTGGATT ATGGTACCAG ACTTTTTCAT TCGTTAATGG TTTTGGAGAA GATAATTGGA 
AATTCTGCAT TTCTTCTTAT TTTGAAGGAC AAACTCACAT ACGACTCTTA CTCTCCTGAT 
ACCTTCCTGG AGATGGATTT GAAACAAAAA TCACAAGATT CTCTGCCACA AAAAAATATA 
ATAAGGCTGA GTGCGGAGCC AAGGTACCTT GTGGTCTATA ATCCTTTAGA ACAAGACCGA 
ATCTCGTTGG TCTCAGTCTA TGTGAGTTCC CCGACAGTGC AAGTGTTCTC TGCTTCAGGA 
AAACCTGTGG AAGTTCAAGT CAGCGCAGTT TGGGATACAG CAAATACTAT TTCAGAAACA 
GCCTATGAGA TCTCTTTTCG AGCACATATA CCGCCATTGG GACTGAAAGT GTATAAGATT 
TTGGAATCAG CAAGTTCAAA TTCACATTTA GCTGATTATG TCTTGTATAA GAATAAAGTA 
GAAGATAGCG GAATTTTCAC CATAAAGAAT ATGATAAATA CTGAAGAAGG TATAACACTA 
GAGAACTCCT TTGTTTTACT TCGGTTTGAT CAAACTGGAC TTATGAAGCA AATGATGACT 
AAAGAAGATG GTAAACACCA TGAAGTAAAT GTGCAATTTT CATGGTATGG AACCACAATT 
AAAAGAGACA AAAGTGGTGC CTACCTCTTC TTACCTGATG GTAATGCCAA GCCTTATGTT 
TACACAACAC CGCCCTTTGT CAGAGTGACA CATGGAAGGA TTTATTCGGA AGTGACTTGC 
TTTTTTGACC ATGTTACTCA TAGAGTCCGA CTATACCACA TACAGGGCAT GAAAGAGAAG 
GTTATTTTAA GGGACTGCAA GCACATTCTG GTTACACAGA TTCAGAACTC AGAGGTTATC 
TTTGGGGCTG TTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011541697.1
CDS	1002..3656
Translation	MKLSRQFTVFGSAIFCVVIFSLYLMLDRGHLDYPRNPRREGSFPQGQLSMLQEKIDHLERLLAENNEIISNIRDSVINLSESVEDGPKSSQSNFSQGAGSHLLPSQLSLSVDTADCLFASQSGSHNSDVQMLDVYSLISFDNPDGGVWKQGFDITYESNEWDTEPLQVFVVPHSHNDPGWLKTFNDYFRDKTQYIFNNMVLKLKEDSRRKFIWSEISYLSKWWDIIDIQKKDAVKSLIENGQLEIVTGGWVMPDEATPHYFALIDQLIEGHQWLENNIGVKPRSGWAIDPFGHSPTMAYLLNRAGLSHMLIQRVHYAVKKHFALHKTLEFFWRQNWDLGSVTDILCHMMPFYSYDIPHTCGPDPKICCQFDFKRLPGGRFGCPWGVPPETIHPGNVQSRARMLLDQYRKKSKLFRTKVLLAPLGDDFRYCEYTEWDLQFKNYQQLFDYMNSQSKFKVKIQFGTLSDFFDALDKADETQRDKGQSMFPVLSGDFFTYADRDDHYWSGYFTSRPFYKRMDRIMESHLRAAEILYYFALRQAHKYKINKFLSSSLYTALTEARRNLGLFQHHDAITGTAKDWVVVDYGTRLFHSLMVLEKIIGNSAFLLILKDKLTYDSYSPDTFLEMDLKQKSQDSLPQKNIIRLSAEPRYLVVYNPLEQDRISLVSVYVSSPTVQVFSASGKPVEVQVSAVWDTANTISETAYEISFRAHIPPLGLKVYKILESASSNSHLADYVLYKNKVEDSGIFTIKNMINTEEGITLENSFVLLRFDQTGLMKQMMTKEDGKHHEVNVQFSWYGTTIKRDKSGAYLFLPDGNAKPYVYTTPPFVRVTHGRIYSEVTCFFDHVTHRVRLYHIQGMKEKVILRDCKHILVTQIQNSEVIFGAV

Target ORF information:

RefSeq Version	XM_011543395.3
Organism	Homo sapiens(human)
Definition	Homo sapiens mannosidase alpha class 2A member 1 (MAN2A1), transcript variant X3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011543395.3

ORF Insert Sequence:

ATGAAGTTAA GCCGCCAGTT CACCGTGTTC GGCAGTGCGA TCTTCTGTGT GGTGATTTTC 
TCGCTCTACC TGATGCTGGA CCGGGGTCAC TTAGACTACC CCAGGAACCC GCGCCGCGAG 
GGCTCCTTCC CTCAGGGCCA GCTCTCAATG TTGCAAGAAA AAATAGACCA TTTGGAGCGT 
TTGCTAGCTG AGAATAATGA GATCATCTCA AATATTAGAG ACTCAGTCAT CAATTTGAGT 
GAGTCTGTGG AGGATGGTCC GAAAAGTTCA CAAAGCAATT TCAGCCAAGG TGCTGGCTCA 
CATCTTCTGC CCTCACAATT ATCCCTCTCA GTTGACACTG CAGACTGTCT GTTTGCTTCA 
CAAAGTGGAA GTCACAATTC AGATGTGCAG ATGTTGGATG TTTACAGTCT AATTTCTTTT 
GACAATCCAG ATGGTGGAGT TTGGAAGCAA GGATTTGACA TTACTTATGA ATCTAATGAA 
TGGGACACTG AACCCCTTCA AGTCTTTGTG GTGCCTCATT CCCATAACGA CCCAGGTTGG 
TTGAAGACTT TCAATGACTA CTTTAGAGAC AAGACTCAGT ATATTTTTAA TAACATGGTC 
CTAAAGCTGA AAGAAGACTC ACGGAGGAAG TTTATTTGGT CTGAGATCTC TTACCTTTCA 
AAGTGGTGGG ATATTATAGA TATTCAGAAG AAGGATGCTG TTAAAAGTTT AATAGAAAAT 
GGTCAGCTTG AAATTGTGAC AGGTGGCTGG GTTATGCCTG ATGAAGCTAC TCCACATTAT 
TTTGCCTTAA TTGATCAACT AATTGAAGGA CATCAGTGGC TGGAAAATAA TATAGGAGTG 
AAACCTCGGT CCGGCTGGGC TATTGATCCC TTTGGACACT CACCAACAAT GGCTTATCTT 
CTAAACCGTG CTGGACTTTC TCACATGCTT ATCCAGAGAG TTCATTATGC AGTTAAAAAA 
CACTTTGCAC TGCATAAAAC ATTGGAGTTT TTTTGGAGAC AGAATTGGGA TCTGGGATCT 
GTCACAGATA TTTTATGCCA CATGATGCCC TTCTACAGCT ATGACATCCC TCACACTTGT 
GGACCTGATC CTAAAATATG CTGCCAGTTT GATTTTAAAC GTCTTCCTGG AGGCAGATTT 
GGTTGTCCCT GGGGAGTCCC CCCAGAAACA ATACATCCTG GAAATGTCCA AAGCAGGGCT 
CGGATGCTAC TAGATCAGTA CCGAAAGAAG TCAAAGCTTT TTCGTACCAA AGTTCTCCTG 
GCTCCACTAG GAGATGATTT CCGCTACTGT GAATACACGG AATGGGATTT ACAGTTTAAG 
AATTATCAGC AGCTTTTTGA TTATATGAAT TCTCAGTCCA AGTTTAAAGT TAAGATACAG 
TTTGGAACTT TATCAGATTT TTTTGATGCG CTGGATAAAG CAGATGAAAC TCAGAGAGAC 
AAGGGCCAAT CGATGTTCCC TGTTTTAAGT GGAGATTTTT TCACTTATGC CGATCGAGAT 
GATCATTACT GGAGTGGCTA TTTTACATCC AGACCCTTTT ACAAACGAAT GGACAGAATC 
ATGGAATCTC ATTTAAGGGC TGCTGAAATT CTTTACTATT TCGCCCTGAG ACAAGCTCAC 
AAATACAAGA TAAATAAATT TCTCTCATCA TCACTTTACA CGGCACTGAC AGAAGCCAGA 
AGGAATTTGG GACTGTTTCA ACATCATGAT GCTATCACAG GAACTGCAAA AGACTGGGTG 
GTTGTGGATT ATGGTACCAG ACTTTTTCAT TCGTTAATGG TTTTGGAGAA GATAATTGGA 
AATTCTGCAT TTCTTCTTAT TTTGAAGGAC AAACTCACAT ACGACTCTTA CTCTCCTGAT 
ACCTTCCTGG AGATGGATTT GAAACAAAAA TCACAAGATT CTCTGCCACA AAAAAATATA 
ATAAGGCTGA GTGCGGAGCC AAGGTACCTT GTGGTCTATA ATCCTTTAGA ACAAGACCGA 
ATCTCGTTGG TCTCAGTCTA TGTGAGTTCC CCGACAGTGC AAGTGTTCTC TGCTTCAGGA 
AAACCTGTGG AAGTTCAAGT CAGCGCAGTT TGGGATACAG CAAATACTAT TTCAGAAACA 
GCCTATGAGA TCTCTTTTCG AGCACATATA CCGCCATTGG GACTGAAAGT GTATAAGATT 
TTGGAATCAG CAAGTTCAAA TTCACATTTA GCTGATTATG TCTTGTATAA GAATAAAGTA 
GAAGATAGCG GAATTTTCAC CATAAAGAAT ATGATAAATA CTGAAGAAGG TATAACACTA 
GAGAACTCCT TTGTTTTACT TCGGTTTGAT CAAACTGGAC TTATGAAGCA AATGATGACT 
AAAGAAGATG GTAAACACCA TGAAGTAAAT GTGCAATTTT CATGGTATGG AACCACAATT 
AAAAGAGACA AAAGTGGTGC CTACCTCTTC TTACCTGATG GTAATGCCAA GCCTTATGTT 
TACACAACAC CGCCCTTTGT CAGAGTGACA CATGGAAGGA TTTATTCGGA AGTGACTTGC 
TTTTTTGACC ATGTTACTCA TAGAGTCCGA CTATACCACA TACAGGGCAT GAAAGAGAAG 
GTTATTTTAA GGGACTGCAA GCACATTCTG GTTACACAGA TTCAGAACTC AGAGGTTATC 
TTTGGGGCTG TTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MAN2A1 ( XM_024446048.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_024301816.1 Homo sapiens mannosidase alpha class 2A member 1 (MAN2A1), transcript variant X2, mRNA.

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CloneID	OHu105666
Clone ID Related Accession (Same CDS sequence)	XM_024446048.1
Accession Version	XM_024446048.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2841bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	alpha-mannosidase 2 isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000005.10) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGTCCTAA AGCTGAAAGA AGACTCACGG AGGAAGTTTA TTTGGTCTGA GATCTCTTAC 
CTTTCAAAGT GGTGGGATAT TATAGATATT CAGAAGAAGG ATGCTGTTAA AAGTTTAATA 
GAAAATGGTC AGCTTGAAAT TGTGACAGGT GGCTGGGTTA TGCCTGATGA AGCTACTCCA 
CATTATTTTG CCTTAATTGA TCAACTAATT GAAGGACATC AGTGGCTGGA AAATAATATA 
GGAGTGAAAC CTCGGTCCGG CTGGGCTATT GATCCCTTTG GACACTCACC AACAATGGCT 
TATCTTCTAA ACCGTGCTGG ACTTTCTCAC ATGCTTATCC AGAGAGTTCA TTATGCAGTT 
AAAAAACACT TTGCACTGCA TAAAACATTG GAGTTTTTTT GGAGACAGAA TTGGGATCTG 
GGATCTGTCA CAGATATTTT ATGCCACATG ATGCCCTTCT ACAGCTATGA CATCCCTCAC 
ACTTGTGGAC CTGATCCTAA AATATGCTGC CAGTTTGATT TTAAACGTCT TCCTGGAGGC 
AGATTTGGTT GTCCCTGGGG AGTCCCCCCA GAAACAATAC ATCCTGGAAA TGTCCAAAGC 
AGGGCTCGGA TGCTACTAGA TCAGTACCGA AAGAAGTCAA AGCTTTTTCG TACCAAAGTT 
CTCCTGGCTC CACTAGGAGA TGATTTCCGC TACTGTGAAT ACACGGAATG GGATTTACAG 
TTTAAGAATT ATCAGCAGCT TTTTGATTAT ATGAATTCTC AGTCCAAGTT TAAAGTTAAG 
ATACAGTTTG GAACTTTATC AGATTTTTTT GATGCGCTGG ATAAAGCAGA TGAAACTCAG 
AGAGACAAGG GCCAATCGAT GTTCCCTGTT TTAAGTGGAG ATTTTTTCAC TTATGCCGAT 
CGAGATGATC ATTACTGGAG TGGCTATTTT ACATCCAGAC CCTTTTACAA ACGAATGGAC 
AGAATCATGG AATCTCATTT AAGGGCTGCT GAAATTCTTT ACTATTTCGC CCTGAGACAA 
GCTCACAAAT ACAAGATAAA TAAATTTCTC TCATCATCAC TTTACACGGC ACTGACAGAA 
GCCAGAAGGA ATTTGGGACT GTTTCAACAT CATGATGCTA TCACAGGAAC TGCAAAAGAC 
TGGGTGGTTG TGGATTATGG TACCAGACTT TTTCATTCGT TAATGGTTTT GGAGAAGATA 
ATTGGAAATT CTGCATTTCT TCTTATTTTG AAGGACAAAC TCACATACGA CTCTTACTCT 
CCTGATACCT TCCTGGAGAT GGATTTGAAA CAAAAATCAC AAGATTCTCT GCCACAAAAA 
AATATAATAA GGCTGAGTGC GGAGCCAAGG TACCTTGTGG TCTATAATCC TTTAGAACAA 
GACCGAATCT CGTTGGTCTC AGTCTATGTG AGTTCCCCGA CAGTGCAAGT GTTCTCTGCT 
TCAGGAAAAC CTGTGGAAGT TCAAGTCAGC GCAGTTTGGG ATACAGCAAA TACTATTTCA 
GAAACAGCCT ATGAGATCTC TTTTCGAGCA CATATACCGC CATTGGGACT GAAAGTGTAT 
AAGATTTTGG AATCAGCAAG TTCAAATTCA CATTTAGCTG ATTATGTCTT GTATAAGAAT 
AAAGTAGAAG ATAGCGGAAT TTTCACCATA AAGAATATGA TAAATACTGA AGAAGGTATA 
ACACTAGAGA ACTCCTTTGT TTTACTTCGG TTTGATCAAA CTGGACTTAT GAAGCAAATG 
ATGACTAAAG AAGATGGTAA ACACCATGAA GTAAATGTGC AATTTTCATG GTATGGAACC 
ACAATTAAAA GAGACAAAAG TGGTGCCTAC CTCTTCTTAC CTGATGGTAA TGCCAAGCCT 
TATGTTTACA CAACACCGCC CTTTGTCAGA GTGACACATG GAAGGATTTA TTCGGAAGTG 
ACTTGCTTTT TTGACCATGT TACTCATAGA GTCCGACTAT ACCACATACA GGGAATAGAA 
GGACAGTCTG TGGAAGTTTC CAATATTGTG GACATCCGAA AAGTATATAA CCGTGAGATT 
GCAATGAAAA TTTCTTCTGA TATAAAAAGC CAAAATAGAT TTTATACTGA CCTAAATGGG 
TACCAGATTC AACCTAGAAT GACACTGAGC AAATTGCCTC TTCAAGCAAA TGTCTATCCC 
ATGACCACAA TGGCCTATAT CCAGGATGCC AAACATCGTT TGACACTGCT CTCTGCTCAG 
TCATTAGGGG TTTCGAGTTT GAATAGTGGT CAGATTGAAG TTATCATGGA TCGAAGACTC 
ATGCAAGATG ATAATCGTGG CCTTGAGCAA GGTATCCAGG ATAACAAGAT TACAGCTAAT 
CTATTTCGAA TACTACTAGA AAAAAGAAGT GCTGTTAATA CGGAAGAAGA AAAGAAGTCG 
GTCAGTTATC CTTCTCTCCT TAGCCACATA ACTTCTTCTC TCATGAATCA TCCAGTCATT 
CCAATGGCAA ATAAGTTCTC CTCACCTACC CTTGAGCTGC AAGGTGAATT CTCTCCATTA 
CAGTCATCTT TGCCTTGTGA CATTCATCTG GTTAATTTGA GAACAATACA GTCAAAGGTG 
GGCAATGGGC ACTCCAATGA GGCAGCCTTG ATCCTCCACA GAAAAGGGTT TGATTGTCGG 
TTCTCTAGCA AAGGCACAGG GCTGTTTTGT TCTACTACTC AGGGAAAGAT ATTGGTACAG 
AAACTTTTAA ACAAGTTTAT TGTCGAAAGT CTCACACCTT CATCACTATC CTTGATGCAT 
TCACCTCCCG GCACTCAGAA TATAAGTGAG ATCAACTTGA GTCCAATGGA AATCAGCACA 
TTCCGAATCC AGTTGAGGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_024301816.1
CDS	1556..4396
Translation	MVLKLKEDSRRKFIWSEISYLSKWWDIIDIQKKDAVKSLIENGQLEIVTGGWVMPDEATPHYFALIDQLIEGHQWLENNIGVKPRSGWAIDPFGHSPTMAYLLNRAGLSHMLIQRVHYAVKKHFALHKTLEFFWRQNWDLGSVTDILCHMMPFYSYDIPHTCGPDPKICCQFDFKRLPGGRFGCPWGVPPETIHPGNVQSRARMLLDQYRKKSKLFRTKVLLAPLGDDFRYCEYTEWDLQFKNYQQLFDYMNSQSKFKVKIQFGTLSDFFDALDKADETQRDKGQSMFPVLSGDFFTYADRDDHYWSGYFTSRPFYKRMDRIMESHLRAAEILYYFALRQAHKYKINKFLSSSLYTALTEARRNLGLFQHHDAITGTAKDWVVVDYGTRLFHSLMVLEKIIGNSAFLLILKDKLTYDSYSPDTFLEMDLKQKSQDSLPQKNIIRLSAEPRYLVVYNPLEQDRISLVSVYVSSPTVQVFSASGKPVEVQVSAVWDTANTISETAYEISFRAHIPPLGLKVYKILESASSNSHLADYVLYKNKVEDSGIFTIKNMINTEEGITLENSFVLLRFDQTGLMKQMMTKEDGKHHEVNVQFSWYGTTIKRDKSGAYLFLPDGNAKPYVYTTPPFVRVTHGRIYSEVTCFFDHVTHRVRLYHIQGIEGQSVEVSNIVDIRKVYNREIAMKISSDIKSQNRFYTDLNGYQIQPRMTLSKLPLQANVYPMTTMAYIQDAKHRLTLLSAQSLGVSSLNSGQIEVIMDRRLMQDDNRGLEQGIQDNKITANLFRILLEKRSAVNTEEEKKSVSYPSLLSHITSSLMNHPVIPMANKFSSPTLELQGEFSPLQSSLPCDIHLVNLRTIQSKVGNGHSNEAALILHRKGFDCRFSSKGTGLFCSTTQGKILVQKLLNKFIVESLTPSSLSLMHSPPGTQNISEINLSPMEISTFRIQLR

Target ORF information:

RefSeq Version	XM_024446048.1
Organism	Homo sapiens(human)
Definition	Homo sapiens mannosidase alpha class 2A member 1 (MAN2A1), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_024446048.1

ORF Insert Sequence:

ATGGTCCTAA AGCTGAAAGA AGACTCACGG AGGAAGTTTA TTTGGTCTGA GATCTCTTAC 
CTTTCAAAGT GGTGGGATAT TATAGATATT CAGAAGAAGG ATGCTGTTAA AAGTTTAATA 
GAAAATGGTC AGCTTGAAAT TGTGACAGGT GGCTGGGTTA TGCCTGATGA AGCTACTCCA 
CATTATTTTG CCTTAATTGA TCAACTAATT GAAGGACATC AGTGGCTGGA AAATAATATA 
GGAGTGAAAC CTCGGTCCGG CTGGGCTATT GATCCCTTTG GACACTCACC AACAATGGCT 
TATCTTCTAA ACCGTGCTGG ACTTTCTCAC ATGCTTATCC AGAGAGTTCA TTATGCAGTT 
AAAAAACACT TTGCACTGCA TAAAACATTG GAGTTTTTTT GGAGACAGAA TTGGGATCTG 
GGATCTGTCA CAGATATTTT ATGCCACATG ATGCCCTTCT ACAGCTATGA CATCCCTCAC 
ACTTGTGGAC CTGATCCTAA AATATGCTGC CAGTTTGATT TTAAACGTCT TCCTGGAGGC 
AGATTTGGTT GTCCCTGGGG AGTCCCCCCA GAAACAATAC ATCCTGGAAA TGTCCAAAGC 
AGGGCTCGGA TGCTACTAGA TCAGTACCGA AAGAAGTCAA AGCTTTTTCG TACCAAAGTT 
CTCCTGGCTC CACTAGGAGA TGATTTCCGC TACTGTGAAT ACACGGAATG GGATTTACAG 
TTTAAGAATT ATCAGCAGCT TTTTGATTAT ATGAATTCTC AGTCCAAGTT TAAAGTTAAG 
ATACAGTTTG GAACTTTATC AGATTTTTTT GATGCGCTGG ATAAAGCAGA TGAAACTCAG 
AGAGACAAGG GCCAATCGAT GTTCCCTGTT TTAAGTGGAG ATTTTTTCAC TTATGCCGAT 
CGAGATGATC ATTACTGGAG TGGCTATTTT ACATCCAGAC CCTTTTACAA ACGAATGGAC 
AGAATCATGG AATCTCATTT AAGGGCTGCT GAAATTCTTT ACTATTTCGC CCTGAGACAA 
GCTCACAAAT ACAAGATAAA TAAATTTCTC TCATCATCAC TTTACACGGC ACTGACAGAA 
GCCAGAAGGA ATTTGGGACT GTTTCAACAT CATGATGCTA TCACAGGAAC TGCAAAAGAC 
TGGGTGGTTG TGGATTATGG TACCAGACTT TTTCATTCGT TAATGGTTTT GGAGAAGATA 
ATTGGAAATT CTGCATTTCT TCTTATTTTG AAGGACAAAC TCACATACGA CTCTTACTCT 
CCTGATACCT TCCTGGAGAT GGATTTGAAA CAAAAATCAC AAGATTCTCT GCCACAAAAA 
AATATAATAA GGCTGAGTGC GGAGCCAAGG TACCTTGTGG TCTATAATCC TTTAGAACAA 
GACCGAATCT CGTTGGTCTC AGTCTATGTG AGTTCCCCGA CAGTGCAAGT GTTCTCTGCT 
TCAGGAAAAC CTGTGGAAGT TCAAGTCAGC GCAGTTTGGG ATACAGCAAA TACTATTTCA 
GAAACAGCCT ATGAGATCTC TTTTCGAGCA CATATACCGC CATTGGGACT GAAAGTGTAT 
AAGATTTTGG AATCAGCAAG TTCAAATTCA CATTTAGCTG ATTATGTCTT GTATAAGAAT 
AAAGTAGAAG ATAGCGGAAT TTTCACCATA AAGAATATGA TAAATACTGA AGAAGGTATA 
ACACTAGAGA ACTCCTTTGT TTTACTTCGG TTTGATCAAA CTGGACTTAT GAAGCAAATG 
ATGACTAAAG AAGATGGTAA ACACCATGAA GTAAATGTGC AATTTTCATG GTATGGAACC 
ACAATTAAAA GAGACAAAAG TGGTGCCTAC CTCTTCTTAC CTGATGGTAA TGCCAAGCCT 
TATGTTTACA CAACACCGCC CTTTGTCAGA GTGACACATG GAAGGATTTA TTCGGAAGTG 
ACTTGCTTTT TTGACCATGT TACTCATAGA GTCCGACTAT ACCACATACA GGGAATAGAA 
GGACAGTCTG TGGAAGTTTC CAATATTGTG GACATCCGAA AAGTATATAA CCGTGAGATT 
GCAATGAAAA TTTCTTCTGA TATAAAAAGC CAAAATAGAT TTTATACTGA CCTAAATGGG 
TACCAGATTC AACCTAGAAT GACACTGAGC AAATTGCCTC TTCAAGCAAA TGTCTATCCC 
ATGACCACAA TGGCCTATAT CCAGGATGCC AAACATCGTT TGACACTGCT CTCTGCTCAG 
TCATTAGGGG TTTCGAGTTT GAATAGTGGT CAGATTGAAG TTATCATGGA TCGAAGACTC 
ATGCAAGATG ATAATCGTGG CCTTGAGCAA GGTATCCAGG ATAACAAGAT TACAGCTAAT 
CTATTTCGAA TACTACTAGA AAAAAGAAGT GCTGTTAATA CGGAAGAAGA AAAGAAGTCG 
GTCAGTTATC CTTCTCTCCT TAGCCACATA ACTTCTTCTC TCATGAATCA TCCAGTCATT 
CCAATGGCAA ATAAGTTCTC CTCACCTACC CTTGAGCTGC AAGGTGAATT CTCTCCATTA 
CAGTCATCTT TGCCTTGTGA CATTCATCTG GTTAATTTGA GAACAATACA GTCAAAGGTG 
GGCAATGGGC ACTCCAATGA GGCAGCCTTG ATCCTCCACA GAAAAGGGTT TGATTGTCGG 
TTCTCTAGCA AAGGCACAGG GCTGTTTTGT TCTACTACTC AGGGAAAGAT ATTGGTACAG 
AAACTTTTAA ACAAGTTTAT TGTCGAAAGT CTCACACCTT CATCACTATC CTTGATGCAT 
TCACCTCCCG GCACTCAGAA TATAAGTGAG ATCAACTTGA GTCCAATGGA AATCAGCACA 
TTCCGAATCC AGTTGAGGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MAN2A1 ( NM_002372.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_002363.2 Homo sapiens mannosidase alpha class 2A member 1 (MAN2A1), mRNA.

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CloneID	OHu10839
Clone ID Related Accession (Same CDS sequence)	NM_002372.3
Accession Version	NM_002372.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3435bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-04
Organism	Homo sapiens(human)
Product	alpha-mannosidase 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC012603.7, BC111062.1, U31520.1, D63998.1, AC011366.6 and AL833486.1. On Dec 19, 2013 this sequence version replaced NM_002372.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: D63998.1, SRR1803617.70937.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGAAGTTAA GCCGCCAGTT CACCGTGTTC GGCAGTGCGA TCTTCTGTGT GGTGATTTTC 
TCGCTCTACC TGATGCTGGA CCGGGGTCAC TTAGACTACC CCAGGAACCC GCGCCGCGAG 
GGCTCCTTCC CTCAGGGCCA GCTCTCAATG TTGCAAGAAA AAATAGACCA TTTGGAGCGT 
TTGCTAGCTG AGAATAATGA GATCATCTCA AATATTAGAG ACTCAGTCAT CAATTTGAGT 
GAGTCTGTGG AGGATGGTCC GAAAAGTTCA CAAAGCAATT TCAGCCAAGG TGCTGGCTCA 
CATCTTCTGC CCTCACAATT ATCCCTCTCA GTTGACACTG CAGACTGTCT GTTTGCTTCA 
CAAAGTGGAA GTCACAATTC AGATGTGCAG ATGTTGGATG TTTACAGTCT AATTTCTTTT 
GACAATCCAG ATGGTGGAGT TTGGAAGCAA GGATTTGACA TTACTTATGA ATCTAATGAA 
TGGGACACTG AACCCCTTCA AGTCTTTGTG GTGCCTCATT CCCATAACGA CCCAGGTTGG 
TTGAAGACTT TCAATGACTA CTTTAGAGAC AAGACTCAGT ATATTTTTAA TAACATGGTC 
CTAAAGCTGA AAGAAGACTC ACGGAGGAAG TTTATTTGGT CTGAGATCTC TTACCTTTCA 
AAGTGGTGGG ATATTATAGA TATTCAGAAG AAGGATGCTG TTAAAAGTTT AATAGAAAAT 
GGTCAGCTTG AAATTGTGAC AGGTGGCTGG GTTATGCCTG ATGAAGCTAC TCCACATTAT 
TTTGCCTTAA TTGATCAACT AATTGAAGGA CATCAGTGGC TGGAAAATAA TATAGGAGTG 
AAACCTCGGT CCGGCTGGGC TATTGATCCC TTTGGACACT CACCAACAAT GGCTTATCTT 
CTAAACCGTG CTGGACTTTC TCACATGCTT ATCCAGAGAG TTCATTATGC AGTTAAAAAA 
CACTTTGCAC TGCATAAAAC ATTGGAGTTT TTTTGGAGAC AGAATTGGGA TCTGGGATCT 
GTCACAGATA TTTTATGCCA CATGATGCCC TTCTACAGCT ATGACATCCC TCACACTTGT 
GGACCTGATC CTAAAATATG CTGCCAGTTT GATTTTAAAC GTCTTCCTGG AGGCAGATTT 
GGTTGTCCCT GGGGAGTCCC CCCAGAAACA ATACATCCTG GAAATGTCCA AAGCAGGGCT 
CGGATGCTAC TAGATCAGTA CCGAAAGAAG TCAAAGCTTT TTCGTACCAA AGTTCTCCTG 
GCTCCACTAG GAGATGATTT CCGCTACTGT GAATACACGG AATGGGATTT ACAGTTTAAG 
AATTATCAGC AGCTTTTTGA TTATATGAAT TCTCAGTCCA AGTTTAAAGT TAAGATACAG 
TTTGGAACTT TATCAGATTT TTTTGATGCG CTGGATAAAG CAGATGAAAC TCAGAGAGAC 
AAGGGCCAAT CGATGTTCCC TGTTTTAAGT GGAGATTTTT TCACTTATGC CGATCGAGAT 
GATCATTACT GGAGTGGCTA TTTTACATCC AGACCCTTTT ACAAACGAAT GGACAGAATC 
ATGGAATCTC ATTTAAGGGC TGCTGAAATT CTTTACTATT TCGCCCTGAG ACAAGCTCAC 
AAATACAAGA TAAATAAATT TCTCTCATCA TCACTTTACA CGGCACTGAC AGAAGCCAGA 
AGGAATTTGG GACTGTTTCA ACATCATGAT GCTATCACAG GAACTGCAAA AGACTGGGTG 
GTTGTGGATT ATGGTACCAG ACTTTTTCAT TCGTTAATGG TTTTGGAGAA GATAATTGGA 
AATTCTGCAT TTCTTCTTAT TTTGAAGGAC AAACTCACAT ACGACTCTTA CTCTCCTGAT 
ACCTTCCTGG AGATGGATTT GAAACAAAAA TCACAAGATT CTCTGCCACA AAAAAATATA 
ATAAGGCTGA GTGCGGAGCC AAGGTACCTT GTGGTCTATA ATCCTTTAGA ACAAGACCGA 
ATCTCGTTGG TCTCAGTCTA TGTGAGTTCC CCGACAGTGC AAGTGTTCTC TGCTTCAGGA 
AAACCTGTGG AAGTTCAAGT CAGCGCAGTT TGGGATACAG CAAATACTAT TTCAGAAACA 
GCCTATGAGA TCTCTTTTCG AGCACATATA CCGCCATTGG GACTGAAAGT GTATAAGATT 
TTGGAATCAG CAAGTTCAAA TTCACATTTA GCTGATTATG TCTTGTATAA GAATAAAGTA 
GAAGATAGCG GAATTTTCAC CATAAAGAAT ATGATAAATA CTGAAGAAGG TATAACACTA 
GAGAACTCCT TTGTTTTACT TCGGTTTGAT CAAACTGGAC TTATGAAGCA AATGATGACT 
AAAGAAGATG GTAAACACCA TGAAGTAAAT GTGCAATTTT CATGGTATGG AACCACAATT 
AAAAGAGACA AAAGTGGTGC CTACCTCTTC TTACCTGATG GTAATGCCAA GCCTTATGTT 
TACACAACAC CGCCCTTTGT CAGAGTGACA CATGGAAGGA TTTATTCGGA AGTGACTTGC 
TTTTTTGACC ATGTTACTCA TAGAGTCCGA CTATACCACA TACAGGGAAT AGAAGGACAG 
TCTGTGGAAG TTTCCAATAT TGTGGACATC CGAAAAGTAT ATAACCGTGA GATTGCAATG 
AAAATTTCTT CTGATATAAA AAGCCAAAAT AGATTTTATA CTGACCTAAA TGGGTACCAG 
ATTCAACCTA GAATGACACT GAGCAAATTG CCTCTTCAAG CAAATGTCTA TCCCATGACC 
ACAATGGCCT ATATCCAGGA TGCCAAACAT CGTTTGACAC TGCTCTCTGC TCAGTCATTA 
GGGGTTTCGA GTTTGAATAG TGGTCAGATT GAAGTTATCA TGGATCGAAG ACTCATGCAA 
GATGATAATC GTGGCCTTGA GCAAGGTATC CAGGATAACA AGATTACAGC TAATCTATTT 
CGAATACTAC TAGAAAAAAG AAGTGCTGTT AATACGGAAG AAGAAAAGAA GTCGGTCAGT 
TATCCTTCTC TCCTTAGCCA CATAACTTCT TCTCTCATGA ATCATCCAGT CATTCCAATG 
GCAAATAAGT TCTCCTCACC TACCCTTGAG CTGCAAGGTG AATTCTCTCC ATTACAGTCA 
TCTTTGCCTT GTGACATTCA TCTGGTTAAT TTGAGAACAA TACAGTCAAA GGTGGGCAAT 
GGGCACTCCA ATGAGGCAGC CTTGATCCTC CACAGAAAAG GGTTTGATTG TCGGTTCTCT 
AGCAAAGGCA CAGGGCTGTT TTGTTCTACT ACTCAGGGAA AGATATTGGT ACAGAAACTT 
TTAAACAAGT TTATTGTCGA AAGTCTCACA CCTTCATCAC TATCCTTGAT GCATTCACCT 
CCCGGCACTC AGAATATAAG TGAGATCAAC TTGAGTCCAA TGGAAATCAG CACATTCCGA 
ATCCAGTTGA GGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002363.2
CDS	1053..4487
Translation	MKLSRQFTVFGSAIFCVVIFSLYLMLDRGHLDYPRNPRREGSFPQGQLSMLQEKIDHLERLLAENNEIISNIRDSVINLSESVEDGPKSSQSNFSQGAGSHLLPSQLSLSVDTADCLFASQSGSHNSDVQMLDVYSLISFDNPDGGVWKQGFDITYESNEWDTEPLQVFVVPHSHNDPGWLKTFNDYFRDKTQYIFNNMVLKLKEDSRRKFIWSEISYLSKWWDIIDIQKKDAVKSLIENGQLEIVTGGWVMPDEATPHYFALIDQLIEGHQWLENNIGVKPRSGWAIDPFGHSPTMAYLLNRAGLSHMLIQRVHYAVKKHFALHKTLEFFWRQNWDLGSVTDILCHMMPFYSYDIPHTCGPDPKICCQFDFKRLPGGRFGCPWGVPPETIHPGNVQSRARMLLDQYRKKSKLFRTKVLLAPLGDDFRYCEYTEWDLQFKNYQQLFDYMNSQSKFKVKIQFGTLSDFFDALDKADETQRDKGQSMFPVLSGDFFTYADRDDHYWSGYFTSRPFYKRMDRIMESHLRAAEILYYFALRQAHKYKINKFLSSSLYTALTEARRNLGLFQHHDAITGTAKDWVVVDYGTRLFHSLMVLEKIIGNSAFLLILKDKLTYDSYSPDTFLEMDLKQKSQDSLPQKNIIRLSAEPRYLVVYNPLEQDRISLVSVYVSSPTVQVFSASGKPVEVQVSAVWDTANTISETAYEISFRAHIPPLGLKVYKILESASSNSHLADYVLYKNKVEDSGIFTIKNMINTEEGITLENSFVLLRFDQTGLMKQMMTKEDGKHHEVNVQFSWYGTTIKRDKSGAYLFLPDGNAKPYVYTTPPFVRVTHGRIYSEVTCFFDHVTHRVRLYHIQGIEGQSVEVSNIVDIRKVYNREIAMKISSDIKSQNRFYTDLNGYQIQPRMTLSKLPLQANVYPMTTMAYIQDAKHRLTLLSAQSLGVSSLNSGQIEVIMDRRLMQDDNRGLEQGIQDNKITANLFRILLEKRSAVNTEEEKKSVSYPSLLSHITSSLMNHPVIPMANKFSSPTLELQGEFSPLQSSLPCDIHLVNLRTIQSKVGNGHSNEAALILHRKGFDCRFSSKGTGLFCSTTQGKILVQKLLNKFIVESLTPSSLSLMHSPPGTQNISEINLSPMEISTFRIQLR

Target ORF information:

RefSeq Version	NM_002372.3
Organism	Homo sapiens(human)
Definition	Homo sapiens mannosidase alpha class 2A member 1 (MAN2A1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002372.3

ORF Insert Sequence:

ATGAAGTTAA GCCGCCAGTT CACCGTGTTC GGCAGTGCGA TCTTCTGTGT GGTGATTTTC 
TCGCTCTACC TGATGCTGGA CCGGGGTCAC TTAGACTACC CCAGGAACCC GCGCCGCGAG 
GGCTCCTTCC CTCAGGGCCA GCTCTCAATG TTGCAAGAAA AAATAGACCA TTTGGAGCGT 
TTGCTAGCTG AGAATAATGA GATCATCTCA AATATTAGAG ACTCAGTCAT CAATTTGAGT 
GAGTCTGTGG AGGATGGTCC GAAAAGTTCA CAAAGCAATT TCAGCCAAGG TGCTGGCTCA 
CATCTTCTGC CCTCACAATT ATCCCTCTCA GTTGACACTG CAGACTGTCT GTTTGCTTCA 
CAAAGTGGAA GTCACAATTC AGATGTGCAG ATGTTGGATG TTTACAGTCT AATTTCTTTT 
GACAATCCAG ATGGTGGAGT TTGGAAGCAA GGATTTGACA TTACTTATGA ATCTAATGAA 
TGGGACACTG AACCCCTTCA AGTCTTTGTG GTGCCTCATT CCCATAACGA CCCAGGTTGG 
TTGAAGACTT TCAATGACTA CTTTAGAGAC AAGACTCAGT ATATTTTTAA TAACATGGTC 
CTAAAGCTGA AAGAAGACTC ACGGAGGAAG TTTATTTGGT CTGAGATCTC TTACCTTTCA 
AAGTGGTGGG ATATTATAGA TATTCAGAAG AAGGATGCTG TTAAAAGTTT AATAGAAAAT 
GGTCAGCTTG AAATTGTGAC AGGTGGCTGG GTTATGCCTG ATGAAGCTAC TCCACATTAT 
TTTGCCTTAA TTGATCAACT AATTGAAGGA CATCAGTGGC TGGAAAATAA TATAGGAGTG 
AAACCTCGGT CCGGCTGGGC TATTGATCCC TTTGGACACT CACCAACAAT GGCTTATCTT 
CTAAACCGTG CTGGACTTTC TCACATGCTT ATCCAGAGAG TTCATTATGC AGTTAAAAAA 
CACTTTGCAC TGCATAAAAC ATTGGAGTTT TTTTGGAGAC AGAATTGGGA TCTGGGATCT 
GTCACAGATA TTTTATGCCA CATGATGCCC TTCTACAGCT ATGACATCCC TCACACTTGT 
GGACCTGATC CTAAAATATG CTGCCAGTTT GATTTTAAAC GTCTTCCTGG AGGCAGATTT 
GGTTGTCCCT GGGGAGTCCC CCCAGAAACA ATACATCCTG GAAATGTCCA AAGCAGGGCT 
CGGATGCTAC TAGATCAGTA CCGAAAGAAG TCAAAGCTTT TTCGTACCAA AGTTCTCCTG 
GCTCCACTAG GAGATGATTT CCGCTACTGT GAATACACGG AATGGGATTT ACAGTTTAAG 
AATTATCAGC AGCTTTTTGA TTATATGAAT TCTCAGTCCA AGTTTAAAGT TAAGATACAG 
TTTGGAACTT TATCAGATTT TTTTGATGCG CTGGATAAAG CAGATGAAAC TCAGAGAGAC 
AAGGGCCAAT CGATGTTCCC TGTTTTAAGT GGAGATTTTT TCACTTATGC CGATCGAGAT 
GATCATTACT GGAGTGGCTA TTTTACATCC AGACCCTTTT ACAAACGAAT GGACAGAATC 
ATGGAATCTC ATTTAAGGGC TGCTGAAATT CTTTACTATT TCGCCCTGAG ACAAGCTCAC 
AAATACAAGA TAAATAAATT TCTCTCATCA TCACTTTACA CGGCACTGAC AGAAGCCAGA 
AGGAATTTGG GACTGTTTCA ACATCATGAT GCTATCACAG GAACTGCAAA AGACTGGGTG 
GTTGTGGATT ATGGTACCAG ACTTTTTCAT TCGTTAATGG TTTTGGAGAA GATAATTGGA 
AATTCTGCAT TTCTTCTTAT TTTGAAGGAC AAACTCACAT ACGACTCTTA CTCTCCTGAT 
ACCTTCCTGG AGATGGATTT GAAACAAAAA TCACAAGATT CTCTGCCACA AAAAAATATA 
ATAAGGCTGA GTGCGGAGCC AAGGTACCTT GTGGTCTATA ATCCTTTAGA ACAAGACCGA 
ATCTCGTTGG TCTCAGTCTA TGTGAGTTCC CCGACAGTGC AAGTGTTCTC TGCTTCAGGA 
AAACCTGTGG AAGTTCAAGT CAGCGCAGTT TGGGATACAG CAAATACTAT TTCAGAAACA 
GCCTATGAGA TCTCTTTTCG AGCACATATA CCGCCATTGG GACTGAAAGT GTATAAGATT 
TTGGAATCAG CAAGTTCAAA TTCACATTTA GCTGATTATG TCTTGTATAA GAATAAAGTA 
GAAGATAGCG GAATTTTCAC CATAAAGAAT ATGATAAATA CTGAAGAAGG TATAACACTA 
GAGAACTCCT TTGTTTTACT TCGGTTTGAT CAAACTGGAC TTATGAAGCA AATGATGACT 
AAAGAAGATG GTAAACACCA TGAAGTAAAT GTGCAATTTT CATGGTATGG AACCACAATT 
AAAAGAGACA AAAGTGGTGC CTACCTCTTC TTACCTGATG GTAATGCCAA GCCTTATGTT 
TACACAACAC CGCCCTTTGT CAGAGTGACA CATGGAAGGA TTTATTCGGA AGTGACTTGC 
TTTTTTGACC ATGTTACTCA TAGAGTCCGA CTATACCACA TACAGGGAAT AGAAGGACAG 
TCTGTGGAAG TTTCCAATAT TGTGGACATC CGAAAAGTAT ATAACCGTGA GATTGCAATG 
AAAATTTCTT CTGATATAAA AAGCCAAAAT AGATTTTATA CTGACCTAAA TGGGTACCAG 
ATTCAACCTA GAATGACACT GAGCAAATTG CCTCTTCAAG CAAATGTCTA TCCCATGACC 
ACAATGGCCT ATATCCAGGA TGCCAAACAT CGTTTGACAC TGCTCTCTGC TCAGTCATTA 
GGGGTTTCGA GTTTGAATAG TGGTCAGATT GAAGTTATCA TGGATCGAAG ACTCATGCAA 
GATGATAATC GTGGCCTTGA GCAAGGTATC CAGGATAACA AGATTACAGC TAATCTATTT 
CGAATACTAC TAGAAAAAAG AAGTGCTGTT AATACGGAAG AAGAAAAGAA GTCGGTCAGT 
TATCCTTCTC TCCTTAGCCA CATAACTTCT TCTCTCATGA ATCATCCAGT CATTCCAATG 
GCAAATAAGT TCTCCTCACC TACCCTTGAG CTGCAAGGTG AATTCTCTCC ATTACAGTCA 
TCTTTGCCTT GTGACATTCA TCTGGTTAAT TTGAGAACAA TACAGTCAAA GGTGGGCAAT 
GGGCACTCCA ATGAGGCAGC CTTGATCCTC CACAGAAAAG GGTTTGATTG TCGGTTCTCT 
AGCAAAGGCA CAGGGCTGTT TTGTTCTACT ACTCAGGGAA AGATATTGGT ACAGAAACTT 
TTAAACAAGT TTATTGTCGA AAGTCTCACA CCTTCATCAC TATCCTTGAT GCATTCACCT 
CCCGGCACTC AGAATATAAG TGAGATCAAC TTGAGTCCAA TGGAAATCAG CACATTCCGA 
ATCCAGTTGA GGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MAN2A1 ( XM_017009472.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016864961.1 Homo sapiens mannosidase alpha class 2A member 1 (MAN2A1), transcript variant X1, mRNA.

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CloneID	OHu58845
Clone ID Related Accession (Same CDS sequence)	XM_017009472.1
Accession Version	XM_017009472.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3288bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	alpha-mannosidase 2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000005.10) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTTGCAAG AAAAAATAGA CCATTTGGAG CGTTTGCTAG CTGAGAATAA TGAGATCATC 
TCAAATATTA GAGACTCAGT CATCAATTTG AGTGAGTCTG TGGAGGATGG TCCGAAAAGT 
TCACAAAGCA ATTTCAGCCA AGGTGCTGGC TCACATCTTC TGCCCTCACA ATTATCCCTC 
TCAGTTGACA CTGCAGACTG TCTGTTTGCT TCACAAAGTG GAAGTCACAA TTCAGATGTG 
CAGATGTTGG ATGTTTACAG TCTAATTTCT TTTGACAATC CAGATGGTGG AGTTTGGAAG 
CAAGGATTTG ACATTACTTA TGAATCTAAT GAATGGGACA CTGAACCCCT TCAAGTCTTT 
GTGGTGCCTC ATTCCCATAA CGACCCAGGT TGGTTGAAGA CTTTCAATGA CTACTTTAGA 
GACAAGACTC AGTATATTTT TAATAACATG GTCCTAAAGC TGAAAGAAGA CTCACGGAGG 
AAGTTTATTT GGTCTGAGAT CTCTTACCTT TCAAAGTGGT GGGATATTAT AGATATTCAG 
AAGAAGGATG CTGTTAAAAG TTTAATAGAA AATGGTCAGC TTGAAATTGT GACAGGTGGC 
TGGGTTATGC CTGATGAAGC TACTCCACAT TATTTTGCCT TAATTGATCA ACTAATTGAA 
GGACATCAGT GGCTGGAAAA TAATATAGGA GTGAAACCTC GGTCCGGCTG GGCTATTGAT 
CCCTTTGGAC ACTCACCAAC AATGGCTTAT CTTCTAAACC GTGCTGGACT TTCTCACATG 
CTTATCCAGA GAGTTCATTA TGCAGTTAAA AAACACTTTG CACTGCATAA AACATTGGAG 
TTTTTTTGGA GACAGAATTG GGATCTGGGA TCTGTCACAG ATATTTTATG CCACATGATG 
CCCTTCTACA GCTATGACAT CCCTCACACT TGTGGACCTG ATCCTAAAAT ATGCTGCCAG 
TTTGATTTTA AACGTCTTCC TGGAGGCAGA TTTGGTTGTC CCTGGGGAGT CCCCCCAGAA 
ACAATACATC CTGGAAATGT CCAAAGCAGG GCTCGGATGC TACTAGATCA GTACCGAAAG 
AAGTCAAAGC TTTTTCGTAC CAAAGTTCTC CTGGCTCCAC TAGGAGATGA TTTCCGCTAC 
TGTGAATACA CGGAATGGGA TTTACAGTTT AAGAATTATC AGCAGCTTTT TGATTATATG 
AATTCTCAGT CCAAGTTTAA AGTTAAGATA CAGTTTGGAA CTTTATCAGA TTTTTTTGAT 
GCGCTGGATA AAGCAGATGA AACTCAGAGA GACAAGGGCC AATCGATGTT CCCTGTTTTA 
AGTGGAGATT TTTTCACTTA TGCCGATCGA GATGATCATT ACTGGAGTGG CTATTTTACA 
TCCAGACCCT TTTACAAACG AATGGACAGA ATCATGGAAT CTCATTTAAG GGCTGCTGAA 
ATTCTTTACT ATTTCGCCCT GAGACAAGCT CACAAATACA AGATAAATAA ATTTCTCTCA 
TCATCACTTT ACACGGCACT GACAGAAGCC AGAAGGAATT TGGGACTGTT TCAACATCAT 
GATGCTATCA CAGGAACTGC AAAAGACTGG GTGGTTGTGG ATTATGGTAC CAGACTTTTT 
CATTCGTTAA TGGTTTTGGA GAAGATAATT GGAAATTCTG CATTTCTTCT TATTTTGAAG 
GACAAACTCA CATACGACTC TTACTCTCCT GATACCTTCC TGGAGATGGA TTTGAAACAA 
AAATCACAAG ATTCTCTGCC ACAAAAAAAT ATAATAAGGC TGAGTGCGGA GCCAAGGTAC 
CTTGTGGTCT ATAATCCTTT AGAACAAGAC CGAATCTCGT TGGTCTCAGT CTATGTGAGT 
TCCCCGACAG TGCAAGTGTT CTCTGCTTCA GGAAAACCTG TGGAAGTTCA AGTCAGCGCA 
GTTTGGGATA CAGCAAATAC TATTTCAGAA ACAGCCTATG AGATCTCTTT TCGAGCACAT 
ATACCGCCAT TGGGACTGAA AGTGTATAAG ATTTTGGAAT CAGCAAGTTC AAATTCACAT 
TTAGCTGATT ATGTCTTGTA TAAGAATAAA GTAGAAGATA GCGGAATTTT CACCATAAAG 
AATATGATAA ATACTGAAGA AGGTATAACA CTAGAGAACT CCTTTGTTTT ACTTCGGTTT 
GATCAAACTG GACTTATGAA GCAAATGATG ACTAAAGAAG ATGGTAAACA CCATGAAGTA 
AATGTGCAAT TTTCATGGTA TGGAACCACA ATTAAAAGAG ACAAAAGTGG TGCCTACCTC 
TTCTTACCTG ATGGTAATGC CAAGCCTTAT GTTTACACAA CACCGCCCTT TGTCAGAGTG 
ACACATGGAA GGATTTATTC GGAAGTGACT TGCTTTTTTG ACCATGTTAC TCATAGAGTC 
CGACTATACC ACATACAGGG AATAGAAGGA CAGTCTGTGG AAGTTTCCAA TATTGTGGAC 
ATCCGAAAAG TATATAACCG TGAGATTGCA ATGAAAATTT CTTCTGATAT AAAAAGCCAA 
AATAGATTTT ATACTGACCT AAATGGGTAC CAGATTCAAC CTAGAATGAC ACTGAGCAAA 
TTGCCTCTTC AAGCAAATGT CTATCCCATG ACCACAATGG CCTATATCCA GGATGCCAAA 
CATCGTTTGA CACTGCTCTC TGCTCAGTCA TTAGGGGTTT CGAGTTTGAA TAGTGGTCAG 
ATTGAAGTTA TCATGGATCG AAGACTCATG CAAGATGATA ATCGTGGCCT TGAGCAAGGT 
ATCCAGGATA ACAAGATTAC AGCTAATCTA TTTCGAATAC TACTAGAAAA AAGAAGTGCT 
GTTAATACGG AAGAAGAAAA GAAGTCGGTC AGTTATCCTT CTCTCCTTAG CCACATAACT 
TCTTCTCTCA TGAATCATCC AGTCATTCCA ATGGCAAATA AGTTCTCCTC ACCTACCCTT 
GAGCTGCAAG GTGAATTCTC TCCATTACAG TCATCTTTGC CTTGTGACAT TCATCTGGTT 
AATTTGAGAA CAATACAGTC AAAGGTGGGC AATGGGCACT CCAATGAGGC AGCCTTGATC 
CTCCACAGAA AAGGGTTTGA TTGTCGGTTC TCTAGCAAAG GCACAGGGCT GTTTTGTTCT 
ACTACTCAGG GAAAGATATT GGTACAGAAA CTTTTAAACA AGTTTATTGT CGAAAGTCTC 
ACACCTTCAT CACTATCCTT GATGCATTCA CCTCCCGGCA CTCAGAATAT AAGTGAGATC 
AACTTGAGTC CAATGGAAAT CAGCACATTC CGAATCCAGT TGAGGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016864961.1
CDS	121..3408
Translation	MLQEKIDHLERLLAENNEIISNIRDSVINLSESVEDGPKSSQSNFSQGAGSHLLPSQLSLSVDTADCLFASQSGSHNSDVQMLDVYSLISFDNPDGGVWKQGFDITYESNEWDTEPLQVFVVPHSHNDPGWLKTFNDYFRDKTQYIFNNMVLKLKEDSRRKFIWSEISYLSKWWDIIDIQKKDAVKSLIENGQLEIVTGGWVMPDEATPHYFALIDQLIEGHQWLENNIGVKPRSGWAIDPFGHSPTMAYLLNRAGLSHMLIQRVHYAVKKHFALHKTLEFFWRQNWDLGSVTDILCHMMPFYSYDIPHTCGPDPKICCQFDFKRLPGGRFGCPWGVPPETIHPGNVQSRARMLLDQYRKKSKLFRTKVLLAPLGDDFRYCEYTEWDLQFKNYQQLFDYMNSQSKFKVKIQFGTLSDFFDALDKADETQRDKGQSMFPVLSGDFFTYADRDDHYWSGYFTSRPFYKRMDRIMESHLRAAEILYYFALRQAHKYKINKFLSSSLYTALTEARRNLGLFQHHDAITGTAKDWVVVDYGTRLFHSLMVLEKIIGNSAFLLILKDKLTYDSYSPDTFLEMDLKQKSQDSLPQKNIIRLSAEPRYLVVYNPLEQDRISLVSVYVSSPTVQVFSASGKPVEVQVSAVWDTANTISETAYEISFRAHIPPLGLKVYKILESASSNSHLADYVLYKNKVEDSGIFTIKNMINTEEGITLENSFVLLRFDQTGLMKQMMTKEDGKHHEVNVQFSWYGTTIKRDKSGAYLFLPDGNAKPYVYTTPPFVRVTHGRIYSEVTCFFDHVTHRVRLYHIQGIEGQSVEVSNIVDIRKVYNREIAMKISSDIKSQNRFYTDLNGYQIQPRMTLSKLPLQANVYPMTTMAYIQDAKHRLTLLSAQSLGVSSLNSGQIEVIMDRRLMQDDNRGLEQGIQDNKITANLFRILLEKRSAVNTEEEKKSVSYPSLLSHITSSLMNHPVIPMANKFSSPTLELQGEFSPLQSSLPCDIHLVNLRTIQSKVGNGHSNEAALILHRKGFDCRFSSKGTGLFCSTTQGKILVQKLLNKFIVESLTPSSLSLMHSPPGTQNISEINLSPMEISTFRIQLR

Target ORF information:

RefSeq Version	XM_017009472.1
Organism	Homo sapiens(human)
Definition	Homo sapiens mannosidase alpha class 2A member 1 (MAN2A1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017009472.1

ORF Insert Sequence:

ATGTTGCAAG AAAAAATAGA CCATTTGGAG CGTTTGCTAG CTGAGAATAA TGAGATCATC 
TCAAATATTA GAGACTCAGT CATCAATTTG AGTGAGTCTG TGGAGGATGG TCCGAAAAGT 
TCACAAAGCA ATTTCAGCCA AGGTGCTGGC TCACATCTTC TGCCCTCACA ATTATCCCTC 
TCAGTTGACA CTGCAGACTG TCTGTTTGCT TCACAAAGTG GAAGTCACAA TTCAGATGTG 
CAGATGTTGG ATGTTTACAG TCTAATTTCT TTTGACAATC CAGATGGTGG AGTTTGGAAG 
CAAGGATTTG ACATTACTTA TGAATCTAAT GAATGGGACA CTGAACCCCT TCAAGTCTTT 
GTGGTGCCTC ATTCCCATAA CGACCCAGGT TGGTTGAAGA CTTTCAATGA CTACTTTAGA 
GACAAGACTC AGTATATTTT TAATAACATG GTCCTAAAGC TGAAAGAAGA CTCACGGAGG 
AAGTTTATTT GGTCTGAGAT CTCTTACCTT TCAAAGTGGT GGGATATTAT AGATATTCAG 
AAGAAGGATG CTGTTAAAAG TTTAATAGAA AATGGTCAGC TTGAAATTGT GACAGGTGGC 
TGGGTTATGC CTGATGAAGC TACTCCACAT TATTTTGCCT TAATTGATCA ACTAATTGAA 
GGACATCAGT GGCTGGAAAA TAATATAGGA GTGAAACCTC GGTCCGGCTG GGCTATTGAT 
CCCTTTGGAC ACTCACCAAC AATGGCTTAT CTTCTAAACC GTGCTGGACT TTCTCACATG 
CTTATCCAGA GAGTTCATTA TGCAGTTAAA AAACACTTTG CACTGCATAA AACATTGGAG 
TTTTTTTGGA GACAGAATTG GGATCTGGGA TCTGTCACAG ATATTTTATG CCACATGATG 
CCCTTCTACA GCTATGACAT CCCTCACACT TGTGGACCTG ATCCTAAAAT ATGCTGCCAG 
TTTGATTTTA AACGTCTTCC TGGAGGCAGA TTTGGTTGTC CCTGGGGAGT CCCCCCAGAA 
ACAATACATC CTGGAAATGT CCAAAGCAGG GCTCGGATGC TACTAGATCA GTACCGAAAG 
AAGTCAAAGC TTTTTCGTAC CAAAGTTCTC CTGGCTCCAC TAGGAGATGA TTTCCGCTAC 
TGTGAATACA CGGAATGGGA TTTACAGTTT AAGAATTATC AGCAGCTTTT TGATTATATG 
AATTCTCAGT CCAAGTTTAA AGTTAAGATA CAGTTTGGAA CTTTATCAGA TTTTTTTGAT 
GCGCTGGATA AAGCAGATGA AACTCAGAGA GACAAGGGCC AATCGATGTT CCCTGTTTTA 
AGTGGAGATT TTTTCACTTA TGCCGATCGA GATGATCATT ACTGGAGTGG CTATTTTACA 
TCCAGACCCT TTTACAAACG AATGGACAGA ATCATGGAAT CTCATTTAAG GGCTGCTGAA 
ATTCTTTACT ATTTCGCCCT GAGACAAGCT CACAAATACA AGATAAATAA ATTTCTCTCA 
TCATCACTTT ACACGGCACT GACAGAAGCC AGAAGGAATT TGGGACTGTT TCAACATCAT 
GATGCTATCA CAGGAACTGC AAAAGACTGG GTGGTTGTGG ATTATGGTAC CAGACTTTTT 
CATTCGTTAA TGGTTTTGGA GAAGATAATT GGAAATTCTG CATTTCTTCT TATTTTGAAG 
GACAAACTCA CATACGACTC TTACTCTCCT GATACCTTCC TGGAGATGGA TTTGAAACAA 
AAATCACAAG ATTCTCTGCC ACAAAAAAAT ATAATAAGGC TGAGTGCGGA GCCAAGGTAC 
CTTGTGGTCT ATAATCCTTT AGAACAAGAC CGAATCTCGT TGGTCTCAGT CTATGTGAGT 
TCCCCGACAG TGCAAGTGTT CTCTGCTTCA GGAAAACCTG TGGAAGTTCA AGTCAGCGCA 
GTTTGGGATA CAGCAAATAC TATTTCAGAA ACAGCCTATG AGATCTCTTT TCGAGCACAT 
ATACCGCCAT TGGGACTGAA AGTGTATAAG ATTTTGGAAT CAGCAAGTTC AAATTCACAT 
TTAGCTGATT ATGTCTTGTA TAAGAATAAA GTAGAAGATA GCGGAATTTT CACCATAAAG 
AATATGATAA ATACTGAAGA AGGTATAACA CTAGAGAACT CCTTTGTTTT ACTTCGGTTT 
GATCAAACTG GACTTATGAA GCAAATGATG ACTAAAGAAG ATGGTAAACA CCATGAAGTA 
AATGTGCAAT TTTCATGGTA TGGAACCACA ATTAAAAGAG ACAAAAGTGG TGCCTACCTC 
TTCTTACCTG ATGGTAATGC CAAGCCTTAT GTTTACACAA CACCGCCCTT TGTCAGAGTG 
ACACATGGAA GGATTTATTC GGAAGTGACT TGCTTTTTTG ACCATGTTAC TCATAGAGTC 
CGACTATACC ACATACAGGG AATAGAAGGA CAGTCTGTGG AAGTTTCCAA TATTGTGGAC 
ATCCGAAAAG TATATAACCG TGAGATTGCA ATGAAAATTT CTTCTGATAT AAAAAGCCAA 
AATAGATTTT ATACTGACCT AAATGGGTAC CAGATTCAAC CTAGAATGAC ACTGAGCAAA 
TTGCCTCTTC AAGCAAATGT CTATCCCATG ACCACAATGG CCTATATCCA GGATGCCAAA 
CATCGTTTGA CACTGCTCTC TGCTCAGTCA TTAGGGGTTT CGAGTTTGAA TAGTGGTCAG 
ATTGAAGTTA TCATGGATCG AAGACTCATG CAAGATGATA ATCGTGGCCT TGAGCAAGGT 
ATCCAGGATA ACAAGATTAC AGCTAATCTA TTTCGAATAC TACTAGAAAA AAGAAGTGCT 
GTTAATACGG AAGAAGAAAA GAAGTCGGTC AGTTATCCTT CTCTCCTTAG CCACATAACT 
TCTTCTCTCA TGAATCATCC AGTCATTCCA ATGGCAAATA AGTTCTCCTC ACCTACCCTT 
GAGCTGCAAG GTGAATTCTC TCCATTACAG TCATCTTTGC CTTGTGACAT TCATCTGGTT 
AATTTGAGAA CAATACAGTC AAAGGTGGGC AATGGGCACT CCAATGAGGC AGCCTTGATC 
CTCCACAGAA AAGGGTTTGA TTGTCGGTTC TCTAGCAAAG GCACAGGGCT GTTTTGTTCT 
ACTACTCAGG GAAAGATATT GGTACAGAAA CTTTTAAACA AGTTTATTGT CGAAAGTCTC 
ACACCTTCAT CACTATCCTT GATGCATTCA CCTCCCGGCA CTCAGAATAT AAGTGAGATC 
AACTTGAGTC CAATGGAAAT CAGCACATTC CGAATCCAGT TGAGGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

MAN2A1-FER Fusion Gene Is Expressed by Human Liver and Other Tumor Types and Has Oncogenic Activity in Mice.
Gastroenterology153(4)1120-1132.e15(2017 Oct)
Chen ZH,Yu YP,Tao J,Liu S,Tseng G,Nalesnik M,Hamilton R,Bhargava R,Nelson JB,Pennathur A,Monga SP,Luketich JD,Michalopoulos GK,Luo JH

Using DFT methodology for more reliable predictive models: Design of inhibitors of Golgi ?-Mannosidase II.
Journal of molecular graphics & modelling6647-57(2016 May)
Bobovsk? A,Tvaro?ka I,K??a J

Biological insights from 108 schizophrenia-associated genetic loci.
Nature511(7510)421-7(2014 Jul)

C4orf41 and TTC-15 are mammalian TRAPP components with a role at an early stage in ER-to-Golgi trafficking.
Molecular biology of the cell22(12)2083-93(2011 Jun)
Scrivens PJ,Noueihed B,Shahrzad N,Hul S,Brunet S,Sacher M

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