| Gene Symbol | LRP6 |
| Entrez Gene ID | 4040 |
| Full Name | LDL receptor related protein 6 |
| Synonyms | ADCAD2,STHAG7 |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Homo sapiens(Human) |
| Genome | |
| Summary | This gene encodes a member of the low density lipoprotein (LDL) receptor gene family. LDL receptors are transmembrane cell surface proteins involved in receptor-mediated endocytosis of lipoprotein and protein ligands. The protein encoded by this gene functions as a receptor or, with Frizzled, a co-receptor for Wnt and thereby transmits the canonical Wnt/beta-catenin signaling cascade. Through its interaction with the Wnt/beta-catenin signaling cascade this gene plays a role in the regulation of cell differentiation, proliferation, and migration and the development of many cancer types. This protein undergoes gamma-secretase dependent RIP- (regulated intramembrane proteolysis) processing but the precise locations of the cleavage sites have not been determined.[provided by RefSeq, Dec 2009]. |
| Disorder MIM: | |
| Disorder Html: | {Coronary artery disease, autosomal dominant, 2}, 610947 (3); Tooth agenesis, selective, 7, 616724 (3) |









































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