IRF6 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	IRF6
Entrez Gene ID	3664
Full Name	interferon regulatory factor 6
Synonyms	LPS,OFC6,PIT,PPS,PPS1,VWS,VWS1
General protein information	Preferred Names interferon regulatory factor 6 Names interferon regulatory factor 6
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 1 Map Location: 1q32.2
Summary	This gene encodes a member of the interferon regulatory transcription factor (IRF) family. Family members share a highly-conserved N-terminal helix-turn-helix DNA-binding domain and a less conserved C-terminal protein-binding domain. The encoded protein may be a transcriptional activator. Mutations in this gene can cause van der Woude syndrome and popliteal pterygium syndrome. Mutations in this gene are also associated with non-syndromic orofacial cleft type 6. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2011].
Disorder MIM:	607199
Disorder Html:	van der Woude syndrome, 119300 (3); Popliteal pterygium syndrome 1, 119500 (3); {Orofacial cleft 6}, 608864 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_006147.4	NP_006138.1	interferon regulatory factor 6 isoform 1
NM_006147.3	NP_006138.1	interferon regulatory factor 6 isoform 1
NM_001206696.1	NP_001193625.1	interferon regulatory factor 6 isoform 2

Pathways from BioSystems

Homologies

	IRF6	XP_001110321.1
Bos taurus (cattle)	IRF6	NP_001070402.1
Gallus gallus (chicken)	IRF6	XP_417990.4
Homo sapiens (human)	IRF6	NP_006138.1
Canis lupus familiaris (dog)	IRF6	XP_005622392.1
Mus musculus (house mouse)	Irf6	NP_058547.2
Xenopus tropicalis (tropical clawed frog)	irf6	NP_001025493.1
Danio rerio (zebrafish)	irf6	NP_956892.1
Pan troglodytes (chimpanzee)	IRF6	XP_514168.2
Rattus norvegicus (Norway rat)	Irf6	NP_001102329.1

Gene Ontology
Bibliography

Related articles in PubMed

Rapid functional analysis of computationally complex rare human IRF6 gene variants using a novel zebrafish model.
Li EB, Truong D, Hallett SA, Mukherjee K, Schutte BC, Liao EC
PLoS genetics13(9)e1007009(2017 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The data presented suggest an important role for cytoplasmic IRF6 in regulating the availability or localization of the NME1/2 complex and thus the dynamic behavior of epithelia during lip/palate development.
Title: Disrupted IRF6-NME1/2 Complexes as a Cause of Cleft Lip/Palate.

Here, we demonstrate the protein functions of human IRF6 missense gene variants could be rapidly assessed in detail by their abilities to rescue the irf6 -/- phenotype in zebrafish through variant mRNA microinjections at the one-cell stage.
Title: Rapid functional analysis of computationally complex rare human IRF6 gene variants using a novel zebrafish model.

Here, the authors have established that IRF6 promotes the differentiation of oral keratinocytes in response to Porphyromonas gingivalis.
Title: Interferon Regulatory Factor 6 Promotes Keratinocyte Differentiation in Response to Porphyromonas gingivalis.

mutations in syndromic orofacial clefting patients
Title: Novel IRF6 Mutations Detected in Orofacial Cleft Patients by Targeted Massively Parallel Sequencing.

IRF6 is aberrantly silenced by DNA methylation of the 5' IRF6 CGI in melanoma
Title: Silencing of interferon regulatory factor gene 6 in melanoma.

The following IRF6 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the IRF6 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu22533	NM_006147.4 Latest version!	Homo sapiens interferon regulatory factor 6 (IRF6), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
OHu23202	NM_001206696.1 Latest version!	Homo sapiens interferon regulatory factor 6 (IRF6), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
View Old Accession Versions >>
OHu22533	NM_006147.3	Homo sapiens interferon regulatory factor 6 (IRF6), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

IRF6 ( NM_006147.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_006138.1 Homo sapiens interferon regulatory factor 6 (IRF6), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu22533
Clone ID Related Accession (Same CDS sequence)	NM_006147.4 , NM_006147.3
Accession Version	NM_006147.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1404bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-31
Organism	Homo sapiens(human)
Product	interferon regulatory factor 6 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA016081.1, BC014852.1 and AL022398.1. This sequence is a reference standard in the RefSeqGene project. On Nov 23, 2018 this sequence version replaced NM_006147.3. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803611.57364.1, SRR1660807.95660.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000367021.8/ ENSP00000355988.3 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCCCTCC ACCCCCGCAG AGTCCGGCTA AAGCCCTGGC TGGTGGCCCA GGTGGATAGT 
GGCCTCTACC CTGGGCTCAT CTGGCTACAC AGGGACTCTA AACGCTTCCA GATTCCCTGG 
AAACATGCCA CCCGGCATAG CCCTCAACAA GAAGAGGAAA ATACCATTTT TAAGGCCTGG 
GCTGTAGAGA CAGGGAAGTA CCAGGAAGGG GTGGATGACC CTGACCCAGC TAAATGGAAG 
GCCCAGCTGC GCTGTGCTCT CAATAAGAGC AGAGAATTCA ACCTGATGTA TGATGGCACC 
AAGGAGGTGC CCATGAACCC AGTGAAGATA TATCAAGTGT GTGACATCCC TCAGCCCCAG 
GGCTCGATCA TTAACCCAGG ATCCACAGGG TCTGCTCCCT GGGATGAGAA GGATAATGAT 
GTGGATGAAG AAGATGAGGA AGATGAGCTG GATCAGTCGC AGCACCATGT TCCCATCCAG 
GACACCTTCC CCTTCCTGAA CATCAATGGT TCTCCCATGG CGCCAGCCAG TGTGGGCAAT 
TGCAGTGTGG GCAACTGCAG CCCGGAGGCA GTGTGGCCCA AAACTGAACC CCTGGAGATG 
GAAGTACCCC AGGCACCTAT ACAGCCCTTC TATAGCTCTC CAGAACTGTG GATCAGCTCT 
CTCCCAATGA CTGACCTGGA CATCAAGTTT CAGTACCGTG GGAAGGAGTA CGGGCAGACC 
ATGACCGTGA GCAACCCTCA GGGCTGCCGA CTCTTCTATG GGGACCTGGG TCCCATGCCT 
GACCAGGAGG AGCTCTTTGG TCCCGTCAGC CTGGAGCAGG TCAAATTCCC AGGTCCTGAG 
CATATTACCA ATGAGAAGCA GAAGCTGTTC ACTAGCAAGC TGCTGGACGT CATGGACAGA 
GGACTGATCC TGGAGGTCAG CGGTCATGCC ATTTATGCCA TCAGGCTGTG CCAGTGCAAG 
GTGTACTGGT CTGGGCCATG TGCCCCATCA CTTGTTGCTC CCAACCTGAT TGAGAGACAA 
AAGAAGGTCA AGCTATTTTG TCTGGAAACA TTCCTTAGCG ATCTCATTGC CCACCAGAAA 
GGACAGATAG AGAAGCAGCC ACCGTTTGAG ATCTACTTAT GCTTTGGGGA AGAATGGCCA 
GATGGGAAAC CATTGGAAAG GAAACTCATC TTGGTTCAGG TCATTCCAGT AGTGGCTCGG 
ATGATCTACG AGATGTTTTC TGGTGATTTC ACACGATCCT TTGATAGTGG CAGTGTCCGC 
CTGCAGATCT CAACCCCAGA CATCAAGGAT AACATCGTTG CTCAGCTGAA GCAGCTGTAC 
CGCATCCTTC AAACCCAGGA GAGCTGGCAG CCCATGCAGC CCACCCCCAG CATGCAACTG 
CCCCCTGCCC TGCCTCCCCA GTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006138.1
CDS	272..1675
Translation	MALHPRRVRLKPWLVAQVDSGLYPGLIWLHRDSKRFQIPWKHATRHSPQQEEENTIFKAWAVETGKYQEGVDDPDPAKWKAQLRCALNKSREFNLMYDGTKEVPMNPVKIYQVCDIPQPQGSIINPGSTGSAPWDEKDNDVDEEDEEDELDQSQHHVPIQDTFPFLNINGSPMAPASVGNCSVGNCSPEAVWPKTEPLEMEVPQAPIQPFYSSPELWISSLPMTDLDIKFQYRGKEYGQTMTVSNPQGCRLFYGDLGPMPDQEELFGPVSLEQVKFPGPEHITNEKQKLFTSKLLDVMDRGLILEVSGHAIYAIRLCQCKVYWSGPCAPSLVAPNLIERQKKVKLFCLETFLSDLIAHQKGQIEKQPPFEIYLCFGEEWPDGKPLERKLILVQVIPVVARMIYEMFSGDFTRSFDSGSVRLQISTPDIKDNIVAQLKQLYRILQTQESWQPMQPTPSMQLPPALPPQ

Target ORF information:

RefSeq Version	NM_006147.4
Organism	Homo sapiens(human)
Definition	Homo sapiens interferon regulatory factor 6 (IRF6), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006147.4

ORF Insert Sequence:

ATGGCCCTCC ACCCCCGCAG AGTCCGGCTA AAGCCCTGGC TGGTGGCCCA GGTGGATAGT 
GGCCTCTACC CTGGGCTCAT CTGGCTACAC AGGGACTCTA AACGCTTCCA GATTCCCTGG 
AAACATGCCA CCCGGCATAG CCCTCAACAA GAAGAGGAAA ATACCATTTT TAAGGCCTGG 
GCTGTAGAGA CAGGGAAGTA CCAGGAAGGG GTGGATGACC CTGACCCAGC TAAATGGAAG 
GCCCAGCTGC GCTGTGCTCT CAATAAGAGC AGAGAATTCA ACCTGATGTA TGATGGCACC 
AAGGAGGTGC CCATGAACCC AGTGAAGATA TATCAAGTGT GTGACATCCC TCAGCCCCAG 
GGCTCGATCA TTAACCCAGG ATCCACAGGG TCTGCTCCCT GGGATGAGAA GGATAATGAT 
GTGGATGAAG AAGATGAGGA AGATGAGCTG GATCAGTCGC AGCACCATGT TCCCATCCAG 
GACACCTTCC CCTTCCTGAA CATCAATGGT TCTCCCATGG CGCCAGCCAG TGTGGGCAAT 
TGCAGTGTGG GCAACTGCAG CCCGGAGGCA GTGTGGCCCA AAACTGAACC CCTGGAGATG 
GAAGTACCCC AGGCACCTAT ACAGCCCTTC TATAGCTCTC CAGAACTGTG GATCAGCTCT 
CTCCCAATGA CTGACCTGGA CATCAAGTTT CAGTACCGTG GGAAGGAGTA CGGGCAGACC 
ATGACCGTGA GCAACCCTCA GGGCTGCCGA CTCTTCTATG GGGACCTGGG TCCCATGCCT 
GACCAGGAGG AGCTCTTTGG TCCCGTCAGC CTGGAGCAGG TCAAATTCCC AGGTCCTGAG 
CATATTACCA ATGAGAAGCA GAAGCTGTTC ACTAGCAAGC TGCTGGACGT CATGGACAGA 
GGACTGATCC TGGAGGTCAG CGGTCATGCC ATTTATGCCA TCAGGCTGTG CCAGTGCAAG 
GTGTACTGGT CTGGGCCATG TGCCCCATCA CTTGTTGCTC CCAACCTGAT TGAGAGACAA 
AAGAAGGTCA AGCTATTTTG TCTGGAAACA TTCCTTAGCG ATCTCATTGC CCACCAGAAA 
GGACAGATAG AGAAGCAGCC ACCGTTTGAG ATCTACTTAT GCTTTGGGGA AGAATGGCCA 
GATGGGAAAC CATTGGAAAG GAAACTCATC TTGGTTCAGG TCATTCCAGT AGTGGCTCGG 
ATGATCTACG AGATGTTTTC TGGTGATTTC ACACGATCCT TTGATAGTGG CAGTGTCCGC 
CTGCAGATCT CAACCCCAGA CATCAAGGAT AACATCGTTG CTCAGCTGAA GCAGCTGTAC 
CGCATCCTTC AAACCCAGGA GAGCTGGCAG CCCATGCAGC CCACCCCCAG CATGCAACTG 
CCCCCTGCCC TGCCTCCCCA GTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

IRF6 ( NM_006147.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_006138.1 Homo sapiens interferon regulatory factor 6 (IRF6), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu22533
Clone ID Related Accession (Same CDS sequence)	NM_006147.4 , NM_006147.3
Accession Version	NM_006147.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1404bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-17
Organism	Homo sapiens(human)
Product	interferon regulatory factor 6 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA016081.1, BC014852.1 and AL022398.1. This sequence is a reference standard in the RefSeqGene project. On May 3, 2011 this sequence version replaced NM_006147.2. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660809.31184.1, SRR1803612.36376.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCCCTCC ACCCCCGCAG AGTCCGGCTA AAGCCCTGGC TGGTGGCCCA GGTGGATAGT 
GGCCTCTACC CTGGGCTCAT CTGGCTACAC AGGGACTCTA AACGCTTCCA GATTCCCTGG 
AAACATGCCA CCCGGCATAG CCCTCAACAA GAAGAGGAAA ATACCATTTT TAAGGCCTGG 
GCTGTAGAGA CAGGGAAGTA CCAGGAAGGG GTGGATGACC CTGACCCAGC TAAATGGAAG 
GCCCAGCTGC GCTGTGCTCT CAATAAGAGC AGAGAATTCA ACCTGATGTA TGATGGCACC 
AAGGAGGTGC CCATGAACCC AGTGAAGATA TATCAAGTGT GTGACATCCC TCAGCCCCAG 
GGCTCGATCA TTAACCCAGG ATCCACAGGG TCTGCTCCCT GGGATGAGAA GGATAATGAT 
GTGGATGAAG AAGATGAGGA AGATGAGCTG GATCAGTCGC AGCACCATGT TCCCATCCAG 
GACACCTTCC CCTTCCTGAA CATCAATGGT TCTCCCATGG CGCCAGCCAG TGTGGGCAAT 
TGCAGTGTGG GCAACTGCAG CCCGGAGGCA GTGTGGCCCA AAACTGAACC CCTGGAGATG 
GAAGTACCCC AGGCACCTAT ACAGCCCTTC TATAGCTCTC CAGAACTGTG GATCAGCTCT 
CTCCCAATGA CTGACCTGGA CATCAAGTTT CAGTACCGTG GGAAGGAGTA CGGGCAGACC 
ATGACCGTGA GCAACCCTCA GGGCTGCCGA CTCTTCTATG GGGACCTGGG TCCCATGCCT 
GACCAGGAGG AGCTCTTTGG TCCCGTCAGC CTGGAGCAGG TCAAATTCCC AGGTCCTGAG 
CATATTACCA ATGAGAAGCA GAAGCTGTTC ACTAGCAAGC TGCTGGACGT CATGGACAGA 
GGACTGATCC TGGAGGTCAG CGGTCATGCC ATTTATGCCA TCAGGCTGTG CCAGTGCAAG 
GTGTACTGGT CTGGGCCATG TGCCCCATCA CTTGTTGCTC CCAACCTGAT TGAGAGACAA 
AAGAAGGTCA AGCTATTTTG TCTGGAAACA TTCCTTAGCG ATCTCATTGC CCACCAGAAA 
GGACAGATAG AGAAGCAGCC ACCGTTTGAG ATCTACTTAT GCTTTGGGGA AGAATGGCCA 
GATGGGAAAC CATTGGAAAG GAAACTCATC TTGGTTCAGG TCATTCCAGT AGTGGCTCGG 
ATGATCTACG AGATGTTTTC TGGTGATTTC ACACGATCCT TTGATAGTGG CAGTGTCCGC 
CTGCAGATCT CAACCCCAGA CATCAAGGAT AACATCGTTG CTCAGCTGAA GCAGCTGTAC 
CGCATCCTTC AAACCCAGGA GAGCTGGCAG CCCATGCAGC CCACCCCCAG CATGCAACTG 
CCCCCTGCCC TGCCTCCCCA GTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006138.1
CDS	305..1708
Translation	MALHPRRVRLKPWLVAQVDSGLYPGLIWLHRDSKRFQIPWKHATRHSPQQEEENTIFKAWAVETGKYQEGVDDPDPAKWKAQLRCALNKSREFNLMYDGTKEVPMNPVKIYQVCDIPQPQGSIINPGSTGSAPWDEKDNDVDEEDEEDELDQSQHHVPIQDTFPFLNINGSPMAPASVGNCSVGNCSPEAVWPKTEPLEMEVPQAPIQPFYSSPELWISSLPMTDLDIKFQYRGKEYGQTMTVSNPQGCRLFYGDLGPMPDQEELFGPVSLEQVKFPGPEHITNEKQKLFTSKLLDVMDRGLILEVSGHAIYAIRLCQCKVYWSGPCAPSLVAPNLIERQKKVKLFCLETFLSDLIAHQKGQIEKQPPFEIYLCFGEEWPDGKPLERKLILVQVIPVVARMIYEMFSGDFTRSFDSGSVRLQISTPDIKDNIVAQLKQLYRILQTQESWQPMQPTPSMQLPPALPPQ

Target ORF information:

RefSeq Version	NM_006147.3
Organism	Homo sapiens(human)
Definition	Homo sapiens interferon regulatory factor 6 (IRF6), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006147.3

ORF Insert Sequence:

ATGGCCCTCC ACCCCCGCAG AGTCCGGCTA AAGCCCTGGC TGGTGGCCCA GGTGGATAGT 
GGCCTCTACC CTGGGCTCAT CTGGCTACAC AGGGACTCTA AACGCTTCCA GATTCCCTGG 
AAACATGCCA CCCGGCATAG CCCTCAACAA GAAGAGGAAA ATACCATTTT TAAGGCCTGG 
GCTGTAGAGA CAGGGAAGTA CCAGGAAGGG GTGGATGACC CTGACCCAGC TAAATGGAAG 
GCCCAGCTGC GCTGTGCTCT CAATAAGAGC AGAGAATTCA ACCTGATGTA TGATGGCACC 
AAGGAGGTGC CCATGAACCC AGTGAAGATA TATCAAGTGT GTGACATCCC TCAGCCCCAG 
GGCTCGATCA TTAACCCAGG ATCCACAGGG TCTGCTCCCT GGGATGAGAA GGATAATGAT 
GTGGATGAAG AAGATGAGGA AGATGAGCTG GATCAGTCGC AGCACCATGT TCCCATCCAG 
GACACCTTCC CCTTCCTGAA CATCAATGGT TCTCCCATGG CGCCAGCCAG TGTGGGCAAT 
TGCAGTGTGG GCAACTGCAG CCCGGAGGCA GTGTGGCCCA AAACTGAACC CCTGGAGATG 
GAAGTACCCC AGGCACCTAT ACAGCCCTTC TATAGCTCTC CAGAACTGTG GATCAGCTCT 
CTCCCAATGA CTGACCTGGA CATCAAGTTT CAGTACCGTG GGAAGGAGTA CGGGCAGACC 
ATGACCGTGA GCAACCCTCA GGGCTGCCGA CTCTTCTATG GGGACCTGGG TCCCATGCCT 
GACCAGGAGG AGCTCTTTGG TCCCGTCAGC CTGGAGCAGG TCAAATTCCC AGGTCCTGAG 
CATATTACCA ATGAGAAGCA GAAGCTGTTC ACTAGCAAGC TGCTGGACGT CATGGACAGA 
GGACTGATCC TGGAGGTCAG CGGTCATGCC ATTTATGCCA TCAGGCTGTG CCAGTGCAAG 
GTGTACTGGT CTGGGCCATG TGCCCCATCA CTTGTTGCTC CCAACCTGAT TGAGAGACAA 
AAGAAGGTCA AGCTATTTTG TCTGGAAACA TTCCTTAGCG ATCTCATTGC CCACCAGAAA 
GGACAGATAG AGAAGCAGCC ACCGTTTGAG ATCTACTTAT GCTTTGGGGA AGAATGGCCA 
GATGGGAAAC CATTGGAAAG GAAACTCATC TTGGTTCAGG TCATTCCAGT AGTGGCTCGG 
ATGATCTACG AGATGTTTTC TGGTGATTTC ACACGATCCT TTGATAGTGG CAGTGTCCGC 
CTGCAGATCT CAACCCCAGA CATCAAGGAT AACATCGTTG CTCAGCTGAA GCAGCTGTAC 
CGCATCCTTC AAACCCAGGA GAGCTGGCAG CCCATGCAGC CCACCCCCAG CATGCAACTG 
CCCCCTGCCC TGCCTCCCCA GTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

IRF6 ( NM_001206696.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001193625.1 Homo sapiens interferon regulatory factor 6 (IRF6), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu23202
Clone ID Related Accession (Same CDS sequence)	NM_001206696.1
Accession Version	NM_001206696.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1119bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-01
Organism	Homo sapiens(human)
Product	interferon regulatory factor 6 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA016081.1, AK296960.1 and AL022398.1. Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus, compared to isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660809.46447.1, AK296960.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTATGATG GCACCAAGGA GGTGCCCATG AACCCAGTGA AGATATATCA AGTGTGTGAC 
ATCCCTCAGC CCCAGGGCTC GATCATTAAC CCAGGATCCA CAGGGTCTGC TCCCTGGGAT 
GAGAAGGATA ATGATGTGGA TGAAGAAGAT GAGGAAGATG AGCTGGATCA GTCGCAGCAC 
CATGTTCCCA TCCAGGACAC CTTCCCCTTC CTGAACATCA ATGGTTCTCC CATGGCGCCA 
GCCAGTGTGG GCAATTGCAG TGTGGGCAAC TGCAGCCCGG AGGCAGTGTG GCCCAAAACT 
GAACCCCTGG AGATGGAAGT ACCCCAGGCA CCTATACAGC CCTTCTATAG CTCTCCAGAA 
CTGTGGATCA GCTCTCTCCC AATGACTGAC CTGGACATCA AGTTTCAGTA CCGTGGGAAG 
GAGTACGGGC AGACCATGAC CGTGAGCAAC CCTCAGGGCT GCCGACTCTT CTATGGGGAC 
CTGGGTCCCA TGCCTGACCA GGAGGAGCTC TTTGGTCCCG TCAGCCTGGA GCAGGTCAAA 
TTCCCAGGTC CTGAGCATAT TACCAATGAG AAGCAGAAGC TGTTCACTAG CAAGCTGCTG 
GACGTCATGG ACAGAGGACT GATCCTGGAG GTCAGCGGTC ATGCCATTTA TGCCATCAGG 
CTGTGCCAGT GCAAGGTGTA CTGGTCTGGG CCATGTGCCC CATCACTTGT TGCTCCCAAC 
CTGATTGAGA GACAAAAGAA GGTCAAGCTA TTTTGTCTGG AAACATTCCT TAGCGATCTC 
ATTGCCCACC AGAAAGGACA GATAGAGAAG CAGCCACCGT TTGAGATCTA CTTATGCTTT 
GGGGAAGAAT GGCCAGATGG GAAACCATTG GAAAGGAAAC TCATCTTGGT TCAGGTCATT 
CCAGTAGTGG CTCGGATGAT CTACGAGATG TTTTCTGGTG ATTTCACACG ATCCTTTGAT 
AGTGGCAGTG TCCGCCTGCA GATCTCAACC CCAGACATCA AGGATAACAT CGTTGCTCAG 
CTGAAGCAGC TGTACCGCAT CCTTCAAACC CAGGAGAGCT GGCAGCCCAT GCAGCCCACC 
CCCAGCATGC AACTGCCCCC TGCCCTGCCT CCCCAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001193625.1
CDS	341..1459
Translation	MYDGTKEVPMNPVKIYQVCDIPQPQGSIINPGSTGSAPWDEKDNDVDEEDEEDELDQSQHHVPIQDTFPFLNINGSPMAPASVGNCSVGNCSPEAVWPKTEPLEMEVPQAPIQPFYSSPELWISSLPMTDLDIKFQYRGKEYGQTMTVSNPQGCRLFYGDLGPMPDQEELFGPVSLEQVKFPGPEHITNEKQKLFTSKLLDVMDRGLILEVSGHAIYAIRLCQCKVYWSGPCAPSLVAPNLIERQKKVKLFCLETFLSDLIAHQKGQIEKQPPFEIYLCFGEEWPDGKPLERKLILVQVIPVVARMIYEMFSGDFTRSFDSGSVRLQISTPDIKDNIVAQLKQLYRILQTQESWQPMQPTPSMQLPPALPPQ

Target ORF information:

RefSeq Version	NM_001206696.1
Organism	Homo sapiens(human)
Definition	Homo sapiens interferon regulatory factor 6 (IRF6), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001206696.1

ORF Insert Sequence:

ATGTATGATG GCACCAAGGA GGTGCCCATG AACCCAGTGA AGATATATCA AGTGTGTGAC 
ATCCCTCAGC CCCAGGGCTC GATCATTAAC CCAGGATCCA CAGGGTCTGC TCCCTGGGAT 
GAGAAGGATA ATGATGTGGA TGAAGAAGAT GAGGAAGATG AGCTGGATCA GTCGCAGCAC 
CATGTTCCCA TCCAGGACAC CTTCCCCTTC CTGAACATCA ATGGTTCTCC CATGGCGCCA 
GCCAGTGTGG GCAATTGCAG TGTGGGCAAC TGCAGCCCGG AGGCAGTGTG GCCCAAAACT 
GAACCCCTGG AGATGGAAGT ACCCCAGGCA CCTATACAGC CCTTCTATAG CTCTCCAGAA 
CTGTGGATCA GCTCTCTCCC AATGACTGAC CTGGACATCA AGTTTCAGTA CCGTGGGAAG 
GAGTACGGGC AGACCATGAC CGTGAGCAAC CCTCAGGGCT GCCGACTCTT CTATGGGGAC 
CTGGGTCCCA TGCCTGACCA GGAGGAGCTC TTTGGTCCCG TCAGCCTGGA GCAGGTCAAA 
TTCCCAGGTC CTGAGCATAT TACCAATGAG AAGCAGAAGC TGTTCACTAG CAAGCTGCTG 
GACGTCATGG ACAGAGGACT GATCCTGGAG GTCAGCGGTC ATGCCATTTA TGCCATCAGG 
CTGTGCCAGT GCAAGGTGTA CTGGTCTGGG CCATGTGCCC CATCACTTGT TGCTCCCAAC 
CTGATTGAGA GACAAAAGAA GGTCAAGCTA TTTTGTCTGG AAACATTCCT TAGCGATCTC 
ATTGCCCACC AGAAAGGACA GATAGAGAAG CAGCCACCGT TTGAGATCTA CTTATGCTTT 
GGGGAAGAAT GGCCAGATGG GAAACCATTG GAAAGGAAAC TCATCTTGGT TCAGGTCATT 
CCAGTAGTGG CTCGGATGAT CTACGAGATG TTTTCTGGTG ATTTCACACG ATCCTTTGAT 
AGTGGCAGTG TCCGCCTGCA GATCTCAACC CCAGACATCA AGGATAACAT CGTTGCTCAG 
CTGAAGCAGC TGTACCGCAT CCTTCAAACC CAGGAGAGCT GGCAGCCCAT GCAGCCCACC 
CCCAGCATGC AACTGCCCCC TGCCCTGCCT CCCCAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Rapid functional analysis of computationally complex rare human IRF6 gene variants using a novel zebrafish model.
PLoS genetics13(9)e1007009(2017 Sep)
Li EB,Truong D,Hallett SA,Mukherjee K,Schutte BC,Liao EC

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IRF6 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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