RAB7B cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	RAB7B
Entrez Gene ID	338382
Full Name	RAB7B, member RAS oncogene family
Synonyms	RAB7
General protein information	Preferred Names RAB7B, member RAS oncogene family Names ras-related protein Rab-7b Ras-related protein Rab-7
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 1 Map Location: 1q32.1

mRNA and Protein(s)

mRNA	Protein	Name
NM_001304839.2	NP_001291768.1	ras-related protein Rab-7b isoform b
NM_001164522.3	NP_001157994.1	ras-related protein Rab-7b isoform a
XM_006711288.3	XP_006711351.1	ras-related protein Rab-7b isoform X1
NM_001164522.2	NP_001157994.1	ras-related protein Rab-7b isoform a
XM_006711288.4	XP_006711351.1	ras-related protein Rab-7b isoform X1
NM_177403.5	NP_796377.3	ras-related protein Rab-7b isoform a
NM_001304839.1	NP_001291768.1	ras-related protein Rab-7b isoform b

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	RAB7B	XP_528612.3
Mus musculus (house mouse)	5430435G22Rik	NP_663484.1
Canis lupus familiaris (dog)	LOC488576	XP_848668.1
Bos taurus (cattle)	RAB7B	NP_001071481.1
Gallus gallus (chicken)	LOC771782	XP_004935005.1
Homo sapiens (human)	RAB7B	NP_796377.3
Rattus norvegicus (Norway rat)	Rab7b	NP_001102798.1
Xenopus tropicalis (tropical clawed frog)	rab7b	NP_001096381.1
	RAB7B	XP_001082679.1

Gene Ontology
Bibliography

Related articles in PubMed

Rab7b modulates autophagic flux by interacting with Atg4B.
Kjos I, Borg Distefano M, S?tre F, Repnik U, Holland P, Jones AT, Engedal N, Simonsen A, Bakke O, Progida C
EMBO reports18(10)1727-1739(2017 Oct)

Trichuris suis soluble products induce Rab7b expression and limit TLR4 responses in human dendritic cells.
Klaver EJ, van der Pouw Kraan TC, Laan LC, Kringel H, Cummings RD, Bouma G, Kraal G, van Die I
Genes and immunity16(6)378-87(2015 Sep)

Identification of a role for the trans-Golgi network in human papillomavirus 16 pseudovirus infection.
Day PM, Thompson CD, Schowalter RM, Lowy DR, Schiller JT
Journal of virology87(7)3862-70(2013 Apr)

Dynamics of Rab7b-dependent transport of sorting receptors.
Progida C, Nielsen MS, Koster G, Bucci C, Bakke O
Traffic (Copenhagen, Denmark)13(9)1273-85(2012 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Authors determined the effects of T. suis soluble products (SPs) on Toll-like receptor-4 (TLR4)- In addition, T. suis SPs induce Rab7b, a negative regulator of TLR4 signalling
Title: Trichuris suis soluble products induce Rab7b expression and limit TLR4 responses in human dendritic cells.

Rab9a and Rab7b are mediators of the transit of the L2 capsid protien and the pseudogenome of human papillomavirus 16 from the late endosome to the golgi complex.
Title: Identification of a role for the trans-Golgi network in human papillomavirus 16 pseudovirus infection.

Rab7b is required for sortilin transport from endosomes to the TGN.
Title: Dynamics of Rab7b-dependent transport of sorting receptors.

Rab7b may play important roles in megakaryopoiesis by activating NF-kappaB and promoting IL-6 production.
Title: Small Rab GTPase Rab7b promotes megakaryocytic differentiation by enhancing IL-6 production and STAT3-GATA-1 association.

Rab7b is required for normal lysosome function, and, in particular, it is an essential factor for retrograde transport from endosomes to the trans-Golgi network.
Title: Rab7b controls trafficking from endosomes to the TGN.

The following RAB7B gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the RAB7B cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu03583	NM_001164522.3 Latest version!	Homo sapiens RAB7B, member RAS oncogene family (RAB7B), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu03583	NM_177403.5 Latest version!	Homo sapiens RAB7B, member RAS oncogene family (RAB7B), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu79181	NM_001304839.2 Latest version!	Homo sapiens RAB7B, member RAS oncogene family (RAB7B), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OHu34332	XM_006711288.4 Latest version!	Homo sapiens RAB7B, member RAS oncogene family (RAB7B), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
View Old Accession Versions >>
OHu03583	NM_001164522.2	Homo sapiens RAB7B, member RAS oncogene family (RAB7B), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu34332	XM_006711288.3	Homo sapiens RAB7B, member RAS oncogene family (RAB7B), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OHu79181	NM_001304839.1	Homo sapiens RAB7B, member RAS oncogene family (RAB7B), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

RAB7B ( NM_001164522.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_001157994.1 Homo sapiens RAB7B, member RAS oncogene family (RAB7B), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu03583
Clone ID Related Accession (Same CDS sequence)	NM_001164522.3 , NM_001164522.2 , NM_177403.5
Accession Version	NM_001164522.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 600bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-29
Organism	Homo sapiens(human)
Product	ras-related protein Rab-7b isoform a
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AUXG01000006.1. On Nov 22, 2018 this sequence version replaced NM_001164522.2. Transcript Variant: This variant (2) represents use of an alternate promoter and 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same isoform (a). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: SRR1660807.211542.1, SRR1803614.119416.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000617070.5/ ENSP00000482499.1 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGAATCCCC GGAAGAAGGT GGACCTGAAA CTCATTATCG TCGGAGCCAT TGGTGTGGGA 
AAGACCTCCC TCCTTCACCA ATATGTGCAC AAGACGTTTT ATGAGGAATA CCAGACCACA 
CTGGGGGCCA GCATCCTCTC CAAGATTATC ATATTGGGTG ACACAACTTT GAAGTTACAG 
ATCTGGGACA CGGGCGGTCA GGAGCGGTTC CGCTCCATGG TGTCCACGTT CTACAAGGGC 
TCCGATGGCT GCATCCTAGC TTTTGATGTC ACCGACCTGG AGTCTTTTGA AGCCCTGGAT 
ATCTGGCGGG GTGATGTCCT GGCCAAGATT GTCCCCATGG AGCAGTCCTA CCCCATGGTG 
TTGTTGGGGA ACAAGATCGA TCTGGCAGAC CGGAAGGTAC CCCAGGAAGT AGCTCAAGGC 
TGGTGTAGAG AGAAAGATAT TCCTTACTTT GAAGTCAGTG CCAAGAATGA CATCAATGTG 
GTGCAAGCGT TTGAGATGCT GGCCAGTAGG GCTCTGTCGA GGTACCAGAG CATCTTAGAA 
AATCACCTCA CAGAATCCAT CAAGCTCTCG CCAGACCAGT CAAGGAGCAG ATGCTGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001157994.1
CDS	160..759
Translation	MNPRKKVDLKLIIVGAIGVGKTSLLHQYVHKTFYEEYQTTLGASILSKIIILGDTTLKLQIWDTGGQERFRSMVSTFYKGSDGCILAFDVTDLESFEALDIWRGDVLAKIVPMEQSYPMVLLGNKIDLADRKVPQEVAQGWCREKDIPYFEVSAKNDINVVQAFEMLASRALSRYQSILENHLTESIKLSPDQSRSRCC

Target ORF information:

RefSeq Version	NM_001164522.3
Organism	Homo sapiens(human)
Definition	Homo sapiens RAB7B, member RAS oncogene family (RAB7B), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001164522.3

ORF Insert Sequence:

ATGAATCCCC GGAAGAAGGT GGACCTGAAA CTCATTATCG TCGGAGCCAT TGGTGTGGGA 
AAGACCTCCC TCCTTCACCA ATATGTGCAC AAGACGTTTT ATGAGGAATA CCAGACCACA 
CTGGGGGCCA GCATCCTCTC CAAGATTATC ATATTGGGTG ACACAACTTT GAAGTTACAG 
ATCTGGGACA CGGGCGGTCA GGAGCGGTTC CGCTCCATGG TGTCCACGTT CTACAAGGGC 
TCCGATGGCT GCATCCTAGC TTTTGATGTC ACCGACCTGG AGTCTTTTGA AGCCCTGGAT 
ATCTGGCGGG GTGATGTCCT GGCCAAGATT GTCCCCATGG AGCAGTCCTA CCCCATGGTG 
TTGTTGGGGA ACAAGATCGA TCTGGCAGAC CGGAAGGTAC CCCAGGAAGT AGCTCAAGGC 
TGGTGTAGAG AGAAAGATAT TCCTTACTTT GAAGTCAGTG CCAAGAATGA CATCAATGTG 
GTGCAAGCGT TTGAGATGCT GGCCAGTAGG GCTCTGTCGA GGTACCAGAG CATCTTAGAA 
AATCACCTCA CAGAATCCAT CAAGCTCTCG CCAGACCAGT CAAGGAGCAG ATGCTGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RAB7B ( NM_001164522.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001157994.1 Homo sapiens RAB7B, member RAS oncogene family (RAB7B), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu03583
Clone ID Related Accession (Same CDS sequence)	NM_001164522.3 , NM_001164522.2 , NM_177403.5
Accession Version	NM_001164522.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 600bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-27
Organism	Homo sapiens(human)
Product	ras-related protein Rab-7b isoform a
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DA966224.1, BC017092.1, AK127140.1, AUXG01000006.1 and AI264357.1. On Feb 11, 2015 this sequence version replaced NM_001164522.1. Transcript Variant: This variant (2) represents use of an alternate promoter and 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same isoform (a). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: SRR1660807.211542.1, SRR1660805.126048.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAATCCCC GGAAGAAGGT GGACCTGAAA CTCATTATCG TCGGAGCCAT TGGTGTGGGA 
AAGACCTCCC TCCTTCACCA ATATGTGCAC AAGACGTTTT ATGAGGAATA CCAGACCACA 
CTGGGGGCCA GCATCCTCTC CAAGATTATC ATATTGGGTG ACACAACTTT GAAGTTACAG 
ATCTGGGACA CGGGCGGTCA GGAGCGGTTC CGCTCCATGG TGTCCACGTT CTACAAGGGC 
TCCGATGGCT GCATCCTAGC TTTTGATGTC ACCGACCTGG AGTCTTTTGA AGCCCTGGAT 
ATCTGGCGGG GTGATGTCCT GGCCAAGATT GTCCCCATGG AGCAGTCCTA CCCCATGGTG 
TTGTTGGGGA ACAAGATCGA TCTGGCAGAC CGGAAGGTAC CCCAGGAAGT AGCTCAAGGC 
TGGTGTAGAG AGAAAGATAT TCCTTACTTT GAAGTCAGTG CCAAGAATGA CATCAATGTG 
GTGCAAGCGT TTGAGATGCT GGCCAGTAGG GCTCTGTCGA GGTACCAGAG CATCTTAGAA 
AATCACCTCA CAGAATCCAT CAAGCTCTCG CCAGACCAGT CAAGGAGCAG ATGCTGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001157994.1
CDS	231..830
Translation	MNPRKKVDLKLIIVGAIGVGKTSLLHQYVHKTFYEEYQTTLGASILSKIIILGDTTLKLQIWDTGGQERFRSMVSTFYKGSDGCILAFDVTDLESFEALDIWRGDVLAKIVPMEQSYPMVLLGNKIDLADRKVPQEVAQGWCREKDIPYFEVSAKNDINVVQAFEMLASRALSRYQSILENHLTESIKLSPDQSRSRCC

Target ORF information:

RefSeq Version	NM_001164522.2
Organism	Homo sapiens(human)
Definition	Homo sapiens RAB7B, member RAS oncogene family (RAB7B), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001164522.2

ORF Insert Sequence:

ATGAATCCCC GGAAGAAGGT GGACCTGAAA CTCATTATCG TCGGAGCCAT TGGTGTGGGA 
AAGACCTCCC TCCTTCACCA ATATGTGCAC AAGACGTTTT ATGAGGAATA CCAGACCACA 
CTGGGGGCCA GCATCCTCTC CAAGATTATC ATATTGGGTG ACACAACTTT GAAGTTACAG 
ATCTGGGACA CGGGCGGTCA GGAGCGGTTC CGCTCCATGG TGTCCACGTT CTACAAGGGC 
TCCGATGGCT GCATCCTAGC TTTTGATGTC ACCGACCTGG AGTCTTTTGA AGCCCTGGAT 
ATCTGGCGGG GTGATGTCCT GGCCAAGATT GTCCCCATGG AGCAGTCCTA CCCCATGGTG 
TTGTTGGGGA ACAAGATCGA TCTGGCAGAC CGGAAGGTAC CCCAGGAAGT AGCTCAAGGC 
TGGTGTAGAG AGAAAGATAT TCCTTACTTT GAAGTCAGTG CCAAGAATGA CATCAATGTG 
GTGCAAGCGT TTGAGATGCT GGCCAGTAGG GCTCTGTCGA GGTACCAGAG CATCTTAGAA 
AATCACCTCA CAGAATCCAT CAAGCTCTCG CCAGACCAGT CAAGGAGCAG ATGCTGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RAB7B ( NM_177403.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_796377.3 Homo sapiens RAB7B, member RAS oncogene family (RAB7B), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu03583
Clone ID Related Accession (Same CDS sequence)	NM_001164522.3 , NM_001164522.2 , NM_177403.5
Accession Version	NM_177403.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 600bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Homo sapiens(human)
Product	ras-related protein Rab-7b isoform a
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BI757251.1, AK127140.1, AUXG01000006.1 and AI264357.1. On Feb 11, 2015 this sequence version replaced NM_177403.4. Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Both variants 1 and 2 encode the same isoform (a). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: BI757251.1, SRR1803616.63336.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAATCCCC GGAAGAAGGT GGACCTGAAA CTCATTATCG TCGGAGCCAT TGGTGTGGGA 
AAGACCTCCC TCCTTCACCA ATATGTGCAC AAGACGTTTT ATGAGGAATA CCAGACCACA 
CTGGGGGCCA GCATCCTCTC CAAGATTATC ATATTGGGTG ACACAACTTT GAAGTTACAG 
ATCTGGGACA CGGGCGGTCA GGAGCGGTTC CGCTCCATGG TGTCCACGTT CTACAAGGGC 
TCCGATGGCT GCATCCTAGC TTTTGATGTC ACCGACCTGG AGTCTTTTGA AGCCCTGGAT 
ATCTGGCGGG GTGATGTCCT GGCCAAGATT GTCCCCATGG AGCAGTCCTA CCCCATGGTG 
TTGTTGGGGA ACAAGATCGA TCTGGCAGAC CGGAAGGTAC CCCAGGAAGT AGCTCAAGGC 
TGGTGTAGAG AGAAAGATAT TCCTTACTTT GAAGTCAGTG CCAAGAATGA CATCAATGTG 
GTGCAAGCGT TTGAGATGCT GGCCAGTAGG GCTCTGTCGA GGTACCAGAG CATCTTAGAA 
AATCACCTCA CAGAATCCAT CAAGCTCTCG CCAGACCAGT CAAGGAGCAG ATGCTGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_796377.3
CDS	305..904
Translation	MNPRKKVDLKLIIVGAIGVGKTSLLHQYVHKTFYEEYQTTLGASILSKIIILGDTTLKLQIWDTGGQERFRSMVSTFYKGSDGCILAFDVTDLESFEALDIWRGDVLAKIVPMEQSYPMVLLGNKIDLADRKVPQEVAQGWCREKDIPYFEVSAKNDINVVQAFEMLASRALSRYQSILENHLTESIKLSPDQSRSRCC

Target ORF information:

RefSeq Version	NM_177403.5
Organism	Homo sapiens(human)
Definition	Homo sapiens RAB7B, member RAS oncogene family (RAB7B), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_177403.5

ORF Insert Sequence:

ATGAATCCCC GGAAGAAGGT GGACCTGAAA CTCATTATCG TCGGAGCCAT TGGTGTGGGA 
AAGACCTCCC TCCTTCACCA ATATGTGCAC AAGACGTTTT ATGAGGAATA CCAGACCACA 
CTGGGGGCCA GCATCCTCTC CAAGATTATC ATATTGGGTG ACACAACTTT GAAGTTACAG 
ATCTGGGACA CGGGCGGTCA GGAGCGGTTC CGCTCCATGG TGTCCACGTT CTACAAGGGC 
TCCGATGGCT GCATCCTAGC TTTTGATGTC ACCGACCTGG AGTCTTTTGA AGCCCTGGAT 
ATCTGGCGGG GTGATGTCCT GGCCAAGATT GTCCCCATGG AGCAGTCCTA CCCCATGGTG 
TTGTTGGGGA ACAAGATCGA TCTGGCAGAC CGGAAGGTAC CCCAGGAAGT AGCTCAAGGC 
TGGTGTAGAG AGAAAGATAT TCCTTACTTT GAAGTCAGTG CCAAGAATGA CATCAATGTG 
GTGCAAGCGT TTGAGATGCT GGCCAGTAGG GCTCTGTCGA GGTACCAGAG CATCTTAGAA 
AATCACCTCA CAGAATCCAT CAAGCTCTCG CCAGACCAGT CAAGGAGCAG ATGCTGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RAB7B ( NM_001304839.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001291768.1 Homo sapiens RAB7B, member RAS oncogene family (RAB7B), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu79181
Clone ID Related Accession (Same CDS sequence)	NM_001304839.2 , NM_001304839.1
Accession Version	NM_001304839.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 474bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-09
Organism	Homo sapiens(human)
Product	ras-related protein Rab-7b isoform b
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AUXG01000006.1. On May 31, 2019 this sequence version replaced NM_001304839.1. Transcript Variant: This variant (3) differs in the 5' UTR and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: SRR1803611.31838.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAATCCCC GGAAGAAGGT GGACCTGAAA CTCATTATCG TCGGAGCCAT TGGTGTGGGA 
AAGACCTCCC TCCTTCACCA ATATGTGCAC AAGACGTTTT ATGAGGAATA CCAGACCACA 
CTGGGGGCCA GCATCCTCTC CAAGATTATC ATATTGGGTG ACACAACTTT GAAGTTACAG 
ATCTGGGACA CGGGCGGTCA GGAGCGGTTC CGCTCCATGG TGTCCACGTT CTACAAGGGC 
TCCGATGGCT GCATCCTAGC TTTTGATGTC ACCGACCTGG AGTCTTTTGA AGCCCTGGAT 
ATCTGGCGGG GTGATGTCCT GGCCAAGATT GTCCCCATGG AGCAGTCCTA CCCCATGGTG 
TTGTTGGGGA ACAAGATCGA TCTGGCAGAC CGGAAGTACC AGAGCATCTT AGAAAATCAC 
CTCACAGAAT CCATCAAGCT CTCGCCAGAC CAGTCAAGGA GCAGATGCTG CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001291768.1
CDS	160..633
Translation	MNPRKKVDLKLIIVGAIGVGKTSLLHQYVHKTFYEEYQTTLGASILSKIIILGDTTLKLQIWDTGGQERFRSMVSTFYKGSDGCILAFDVTDLESFEALDIWRGDVLAKIVPMEQSYPMVLLGNKIDLADRKYQSILENHLTESIKLSPDQSRSRCC

Target ORF information:

RefSeq Version	NM_001304839.2
Organism	Homo sapiens(human)
Definition	Homo sapiens RAB7B, member RAS oncogene family (RAB7B), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001304839.2

ORF Insert Sequence:

ATGAATCCCC GGAAGAAGGT GGACCTGAAA CTCATTATCG TCGGAGCCAT TGGTGTGGGA 
AAGACCTCCC TCCTTCACCA ATATGTGCAC AAGACGTTTT ATGAGGAATA CCAGACCACA 
CTGGGGGCCA GCATCCTCTC CAAGATTATC ATATTGGGTG ACACAACTTT GAAGTTACAG 
ATCTGGGACA CGGGCGGTCA GGAGCGGTTC CGCTCCATGG TGTCCACGTT CTACAAGGGC 
TCCGATGGCT GCATCCTAGC TTTTGATGTC ACCGACCTGG AGTCTTTTGA AGCCCTGGAT 
ATCTGGCGGG GTGATGTCCT GGCCAAGATT GTCCCCATGG AGCAGTCCTA CCCCATGGTG 
TTGTTGGGGA ACAAGATCGA TCTGGCAGAC CGGAAGTACC AGAGCATCTT AGAAAATCAC 
CTCACAGAAT CCATCAAGCT CTCGCCAGAC CAGTCAAGGA GCAGATGCTG CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RAB7B ( NM_001304839.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001291768.1 Homo sapiens RAB7B, member RAS oncogene family (RAB7B), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu79181
Clone ID Related Accession (Same CDS sequence)	NM_001304839.2 , NM_001304839.1
Accession Version	NM_001304839.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 474bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-24
Organism	Homo sapiens(human)
Product	ras-related protein Rab-7b isoform b
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DA966224.1, AK122657.1, AK127140.1, AUXG01000006.1 and AI264357.1. Transcript Variant: This variant (3) differs in the 5' UTR and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: SRR1803611.31838.1, AK122657.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAATCCCC GGAAGAAGGT GGACCTGAAA CTCATTATCG TCGGAGCCAT TGGTGTGGGA 
AAGACCTCCC TCCTTCACCA ATATGTGCAC AAGACGTTTT ATGAGGAATA CCAGACCACA 
CTGGGGGCCA GCATCCTCTC CAAGATTATC ATATTGGGTG ACACAACTTT GAAGTTACAG 
ATCTGGGACA CGGGCGGTCA GGAGCGGTTC CGCTCCATGG TGTCCACGTT CTACAAGGGC 
TCCGATGGCT GCATCCTAGC TTTTGATGTC ACCGACCTGG AGTCTTTTGA AGCCCTGGAT 
ATCTGGCGGG GTGATGTCCT GGCCAAGATT GTCCCCATGG AGCAGTCCTA CCCCATGGTG 
TTGTTGGGGA ACAAGATCGA TCTGGCAGAC CGGAAGTACC AGAGCATCTT AGAAAATCAC 
CTCACAGAAT CCATCAAGCT CTCGCCAGAC CAGTCAAGGA GCAGATGCTG CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001291768.1
CDS	231..704
Translation	MNPRKKVDLKLIIVGAIGVGKTSLLHQYVHKTFYEEYQTTLGASILSKIIILGDTTLKLQIWDTGGQERFRSMVSTFYKGSDGCILAFDVTDLESFEALDIWRGDVLAKIVPMEQSYPMVLLGNKIDLADRKYQSILENHLTESIKLSPDQSRSRCC

Target ORF information:

RefSeq Version	NM_001304839.1
Organism	Homo sapiens(human)
Definition	Homo sapiens RAB7B, member RAS oncogene family (RAB7B), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001304839.1

ORF Insert Sequence:

ATGAATCCCC GGAAGAAGGT GGACCTGAAA CTCATTATCG TCGGAGCCAT TGGTGTGGGA 
AAGACCTCCC TCCTTCACCA ATATGTGCAC AAGACGTTTT ATGAGGAATA CCAGACCACA 
CTGGGGGCCA GCATCCTCTC CAAGATTATC ATATTGGGTG ACACAACTTT GAAGTTACAG 
ATCTGGGACA CGGGCGGTCA GGAGCGGTTC CGCTCCATGG TGTCCACGTT CTACAAGGGC 
TCCGATGGCT GCATCCTAGC TTTTGATGTC ACCGACCTGG AGTCTTTTGA AGCCCTGGAT 
ATCTGGCGGG GTGATGTCCT GGCCAAGATT GTCCCCATGG AGCAGTCCTA CCCCATGGTG 
TTGTTGGGGA ACAAGATCGA TCTGGCAGAC CGGAAGTACC AGAGCATCTT AGAAAATCAC 
CTCACAGAAT CCATCAAGCT CTCGCCAGAC CAGTCAAGGA GCAGATGCTG CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RAB7B ( XM_006711288.3 ) cDNA ORF clone, Homo sapiens(human) -> XP_006711351.1 Homo sapiens RAB7B, member RAS oncogene family (RAB7B), transcript variant X1, mRNA.

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CloneID	OHu34332
Clone ID Related Accession (Same CDS sequence)	XM_006711288.3 , XM_006711288.4
Accession Version	XM_006711288.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 570bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-05
Organism	Homo sapiens(human)
Product	ras-related protein Rab-7b isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000001.11) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_006711288.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAATCCCC GGAAGAAGGT GGACCTGAAA CTCATTATCG TCGGAGCCAT TGGTGTGGGA 
AAGACCTCCC TCCTTCACCA ATATGTGCAC AAGACGTTTT ATGAGGAATA CCAGACCACA 
CTGGGGGCCA GCATCCTCTC CAAGATTATC ATATTGGGTG ACACAACTTT GAAGTTACAG 
ATCTGGGACA CGGGCGGTCA GGAGCGGTTC CGCTCCATGG TGTCCACGTT CTACAAGGGC 
TCCGATGGCT GCATCCTAGC TTTTGATGTC ACCGACCTGG AGTCTTTTGA AGCCCTGGAT 
ATCTGGCGGG GTGATGTCCT GGCCAAGATT GTCCCCATGG AGCAGTCCTA CCCCATGGTG 
TTGTTGGGGA ACAAGATCGA TCTGGCAGAC CGGAAGGTAC CCCAGGAAGT AGCTCAAGGC 
TGGTGTAGAG AGAAAGATAT TCCTTACTTT GAAGTCAGTG CCAAGAATGA CATCAATGTG 
GTGCAAGCGT TTGAGATGCT GGCCAGTAGG GCTCTGTCGA GGCCCTCACT GTCTCGGGAA 
AGGAAAAGCA GAGAGGTGTC CCTCTCTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006711351.1
CDS	228..797
Translation	MNPRKKVDLKLIIVGAIGVGKTSLLHQYVHKTFYEEYQTTLGASILSKIIILGDTTLKLQIWDTGGQERFRSMVSTFYKGSDGCILAFDVTDLESFEALDIWRGDVLAKIVPMEQSYPMVLLGNKIDLADRKVPQEVAQGWCREKDIPYFEVSAKNDINVVQAFEMLASRALSRPSLSRERKSREVSLS

Target ORF information:

RefSeq Version	XM_006711288.3
Organism	Homo sapiens(human)
Definition	Homo sapiens RAB7B, member RAS oncogene family (RAB7B), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006711288.3

ORF Insert Sequence:

ATGAATCCCC GGAAGAAGGT GGACCTGAAA CTCATTATCG TCGGAGCCAT TGGTGTGGGA 
AAGACCTCCC TCCTTCACCA ATATGTGCAC AAGACGTTTT ATGAGGAATA CCAGACCACA 
CTGGGGGCCA GCATCCTCTC CAAGATTATC ATATTGGGTG ACACAACTTT GAAGTTACAG 
ATCTGGGACA CGGGCGGTCA GGAGCGGTTC CGCTCCATGG TGTCCACGTT CTACAAGGGC 
TCCGATGGCT GCATCCTAGC TTTTGATGTC ACCGACCTGG AGTCTTTTGA AGCCCTGGAT 
ATCTGGCGGG GTGATGTCCT GGCCAAGATT GTCCCCATGG AGCAGTCCTA CCCCATGGTG 
TTGTTGGGGA ACAAGATCGA TCTGGCAGAC CGGAAGGTAC CCCAGGAAGT AGCTCAAGGC 
TGGTGTAGAG AGAAAGATAT TCCTTACTTT GAAGTCAGTG CCAAGAATGA CATCAATGTG 
GTGCAAGCGT TTGAGATGCT GGCCAGTAGG GCTCTGTCGA GGCCCTCACT GTCTCGGGAA 
AGGAAAAGCA GAGAGGTGTC CCTCTCTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RAB7B ( XM_006711288.4 ) cDNA ORF clone, Homo sapiens(human) -> XP_006711351.1 Homo sapiens RAB7B, member RAS oncogene family (RAB7B), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu34332
Clone ID Related Accession (Same CDS sequence)	XM_006711288.3 , XM_006711288.4
Accession Version	XM_006711288.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 570bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	ras-related protein Rab-7b isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000001.11) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_006711288.3. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAATCCCC GGAAGAAGGT GGACCTGAAA CTCATTATCG TCGGAGCCAT TGGTGTGGGA 
AAGACCTCCC TCCTTCACCA ATATGTGCAC AAGACGTTTT ATGAGGAATA CCAGACCACA 
CTGGGGGCCA GCATCCTCTC CAAGATTATC ATATTGGGTG ACACAACTTT GAAGTTACAG 
ATCTGGGACA CGGGCGGTCA GGAGCGGTTC CGCTCCATGG TGTCCACGTT CTACAAGGGC 
TCCGATGGCT GCATCCTAGC TTTTGATGTC ACCGACCTGG AGTCTTTTGA AGCCCTGGAT 
ATCTGGCGGG GTGATGTCCT GGCCAAGATT GTCCCCATGG AGCAGTCCTA CCCCATGGTG 
TTGTTGGGGA ACAAGATCGA TCTGGCAGAC CGGAAGGTAC CCCAGGAAGT AGCTCAAGGC 
TGGTGTAGAG AGAAAGATAT TCCTTACTTT GAAGTCAGTG CCAAGAATGA CATCAATGTG 
GTGCAAGCGT TTGAGATGCT GGCCAGTAGG GCTCTGTCGA GGCCCTCACT GTCTCGGGAA 
AGGAAAAGCA GAGAGGTGTC CCTCTCTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006711351.1
CDS	235..804
Translation	MNPRKKVDLKLIIVGAIGVGKTSLLHQYVHKTFYEEYQTTLGASILSKIIILGDTTLKLQIWDTGGQERFRSMVSTFYKGSDGCILAFDVTDLESFEALDIWRGDVLAKIVPMEQSYPMVLLGNKIDLADRKVPQEVAQGWCREKDIPYFEVSAKNDINVVQAFEMLASRALSRPSLSRERKSREVSLS

Target ORF information:

RefSeq Version	XM_006711288.4
Organism	Homo sapiens(human)
Definition	Homo sapiens RAB7B, member RAS oncogene family (RAB7B), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006711288.4

ORF Insert Sequence:

ATGAATCCCC GGAAGAAGGT GGACCTGAAA CTCATTATCG TCGGAGCCAT TGGTGTGGGA 
AAGACCTCCC TCCTTCACCA ATATGTGCAC AAGACGTTTT ATGAGGAATA CCAGACCACA 
CTGGGGGCCA GCATCCTCTC CAAGATTATC ATATTGGGTG ACACAACTTT GAAGTTACAG 
ATCTGGGACA CGGGCGGTCA GGAGCGGTTC CGCTCCATGG TGTCCACGTT CTACAAGGGC 
TCCGATGGCT GCATCCTAGC TTTTGATGTC ACCGACCTGG AGTCTTTTGA AGCCCTGGAT 
ATCTGGCGGG GTGATGTCCT GGCCAAGATT GTCCCCATGG AGCAGTCCTA CCCCATGGTG 
TTGTTGGGGA ACAAGATCGA TCTGGCAGAC CGGAAGGTAC CCCAGGAAGT AGCTCAAGGC 
TGGTGTAGAG AGAAAGATAT TCCTTACTTT GAAGTCAGTG CCAAGAATGA CATCAATGTG 
GTGCAAGCGT TTGAGATGCT GGCCAGTAGG GCTCTGTCGA GGCCCTCACT GTCTCGGGAA 
AGGAAAAGCA GAGAGGTGTC CCTCTCTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Rab7b modulates autophagic flux by interacting with Atg4B.
EMBO reports18(10)1727-1739(2017 Oct)
Kjos I,Borg Distefano M,S?tre F,Repnik U,Holland P,Jones AT,Engedal N,Simonsen A,Bakke O,Progida C

Trichuris suis soluble products induce Rab7b expression and limit TLR4 responses in human dendritic cells.
Genes and immunity16(6)378-87(2015 Sep)
Klaver EJ,van der Pouw Kraan TC,Laan LC,Kringel H,Cummings RD,Bouma G,Kraal G,van Die I

Identification of a role for the trans-Golgi network in human papillomavirus 16 pseudovirus infection.
Journal of virology87(7)3862-70(2013 Apr)
Day PM,Thompson CD,Schowalter RM,Lowy DR,Schiller JT

Dynamics of Rab7b-dependent transport of sorting receptors.
Traffic (Copenhagen, Denmark)13(9)1273-85(2012 Sep)
Progida C,Nielsen MS,Koster G,Bucci C,Bakke O

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RAB7B cDNA ORF clone, Homo sapiens(human)

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gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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