TLX3 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	TLX3
Entrez Gene ID	30012
Full Name	T cell leukemia homeobox 3
Synonyms	HOX11L2,RNX
General protein information	Preferred Names T cell leukemia homeobox 3 Names T-cell leukemia homeobox protein 3 homeo box 11-like 2 homeobox protein Hox-11L2
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 5 Map Location: 5q35.1
Summary	The protein encoded by this gene is an orphan homeobox protein that encodes a DNA-binding nuclear transcription factor. A translocation [t(5;14)(q35;q32)] involving this gene is associated with T-cell acute lymphoblastic leukemia (T-ALL) in children and young adults. [provided by RefSeq, Nov 2015].
Disorder MIM:	604640

mRNA and Protein(s)

mRNA	Protein	Name
NM_021025.2	NP_066305.2	T-cell leukemia homeobox protein 3
NM_021025.4	NP_066305.2	T-cell leukemia homeobox protein 3
NM_021025.3	NP_066305.2	T-cell leukemia homeobox protein 3

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	TLX3	XP_546241.3
Bos taurus (cattle)	TLX3	NP_001180120.1
Xenopus tropicalis (tropical clawed frog)	tlx3	NP_001015902.1
	TLX3	XP_001095250.1
Danio rerio (zebrafish)	tlx3b	NP_739572.1
Mus musculus (house mouse)	Tlx3	NP_064300.2
Homo sapiens (human)	TLX3	NP_066305.2
Rattus norvegicus (Norway rat)	Tlx3	XP_573065.3

Gene Ontology
Bibliography

Related articles in PubMed

Immunophenotyping with CD135 and CD117 predicts the FLT3, IL-7R and TLX3 gene mutations in childhood T-cell acute leukemia.
Noronha EP, Andrade FG, Zampier C, de Andrade CF, Terra-Granado E, Pombo-de-Oliveira MS,
Blood cells, molecules & diseases5774-80(2016 Mar)

NKX2-5, SIL/TAL and TLX3/HOX11L2 expression in Egyptian pediatric T-cell acute lymphoblastic leukemia.
Moussa H, Sidhom I
Asia-Pacific journal of clinical oncology12(1)e1-10(2016 Mar)

Prediction of DNA binding motifs from 3D models of transcription factors; identifying TLX3 regulated genes.
Pujato M, Kieken F, Skiles AA, Tapinos N, Fiser A
Nucleic acids research42(22)13500-12(2014 Dec)

The effect of TLX3 expression on the prognosis of pediatric T cell acute lymphocytic leukemia--a systematic review.
Ma J, Hua J, Sha Y, Xie Y
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine35(9)8439-43(2014 Sep)

TLX homeodomain oncogenes mediate T cell maturation arrest in T-ALL via interaction with ETS1 and suppression of TCR? gene expression.
Dadi S, Le Noir S, Payet-Bornet D, Lhermitte L, Zacarias-Cabeza J, Bergeron J, Villar?se P, Vachez E, Dik WA, Millien C, Radford I, Verhoeyen E, Cosset FL, Petit A, Ifrah N, Dombret H, Hermine O, Spicuglia S, Langerak AW, Macintyre EA, Nadel B, Ferrier P, Asnafi V
Cancer cell21(4)563-76(2012 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Immunophenotyping with CD135 and CD117 predicts the FLT3, IL-7R and TLX3 gene mutations in childhood T-cell acute leukemia.
Title: Immunophenotyping with CD135 and CD117 predicts the FLT3, IL-7R and TLX3 gene mutations in childhood T-cell acute leukemia.

Egyptian T-cell acute lymphoblastic leukemia cases seemed to have a different genetic pattern compared to other populations, with a lower incidence of TLX3/HOX11L2 and SIL/TAL but a higher incidence of NKX2-5 expression than recorded in Western countries
Title: NKX2-5, SIL/TAL and TLX3/HOX11L2 expression in Egyptian pediatric T-cell acute lymphoblastic leukemia.

Studies suggest that homeobox protein TLX3 expression is not an indicator for the prognosis of pediatric T cell acute lymphocytic leukemia (T-ALL).
Title: The effect of TLX3 expression on the prognosis of pediatric T cell acute lymphocytic leukemia--a systematic review.

The cortical thymic maturation arrest in T-lineage Acute lymphoblastic leukemias (ALLs) that overexpress TLX1 or TLX3 is due to binding of TLX1/TLX3 to ETS1.
Title: TLX homeodomain oncogenes mediate T cell maturation arrest in T-ALL via interaction with ETS1 and suppression of TCR? gene expression.

these results place TLX1 and TLX3 at the top of an oncogenic transcriptional network controlling leukemia development, and identify RUNX1 as a tumor-suppressor gene in T-ALL
Title: Reverse engineering of TLX oncogenic transcriptional networks identifies RUNX1 as tumor suppressor in T-ALL.

The following TLX3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the TLX3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu03645	NM_021025.4 Latest version!	Homo sapiens T cell leukemia homeobox 3 (TLX3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$154.50-$216.30 $309.00
View Old Accession Versions >>
OHu03645	NM_021025.2	Homo sapiens T-cell leukemia homeobox 3 (TLX3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$154.50-$216.30 $309.00
OHu03645	NM_021025.3	Homo sapiens T cell leukemia homeobox 3 (TLX3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$154.50-$216.30 $309.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

TLX3 ( NM_021025.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_066305.2 Homo sapiens T-cell leukemia homeobox 3 (TLX3), mRNA.

Price & Availability↑

CloneID	OHu03645
Clone ID Related Accession (Same CDS sequence)	NM_021025.2 , NM_021025.4 , NM_021025.3
Accession Version	NM_021025.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 876bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-03-14
Organism	Homo sapiens(Human)
Product	T-cell leukemia homeobox protein 3
Comment

ATGGAGGCGC CCGCCAGCGC GCAGACCCCG CACCCGCACG AGCCCATCAG CTTCGGCATC 
GACCAGATCC TTAACAGCCC GGACCAGGAC AGCGCACCCG CCCCGCGGGG CCCCGACGGC 
GCCAGCTACC TGGGAGGGCC CCCCGGGGGC CGTCCGGGCG CCACATACCC GTCTCTGCCC 
GCCTCCTTTG CGGGCCTCGG CGCGCCCTTC GAGGACGCGG GATCTTACAG TGTGAACCTG 
AGCCTAGCGC CCGCAGGCGT GATCCGGGTG CCGGCGCACA GGCCGCTGCC CGGGGCCGTG 
CCACCGCCTC TGCCAAGCGC GCTACCCGCC ATGCCCTCCG TGCCCACGGT CTCCAGCCTT 
GGCGGTCTCA ATTTCCCCTG GATGGAGAGC AGCCGCCGCT TCGTGAAAGA CCGCTTCACA 
GCGGCGGCCG CACTCACGCC CTTCACCGTG ACCCGGCGCA TCGGCCACCC CTACCAGAAC 
CGGACGCCGC CCAAGCGTAA GAAGCCGCGC ACGTCCTTTT CCCGGGTGCA GATCTGCGAG 
CTGGAAAAGC GCTTCCATCG CCAGAAGTAC CTGGCCTCTG CCGAGAGGGC GGCGCTCGCC 
AAGTCCCTCA AAATGACGGA CGCGCAGGTC AAGACCTGGT TCCAAAACCG GAGGACCAAG 
TGGCGGCGGC AGACGGCGGA GGAGCGGGAG GCGGAGCGGC AGCAGGCGAG CCGGCTCATG 
CTGCAGCTGC AACACGACGC CTTCCAAAAG AGCCTCAACG ACTCCATCCA GCCTGACCCG 
CTCTGTCTGC ACAACTCGTC ACTCTTTGCT CTGCAGAATC TGCAGCCCTG GGAGGAGGAT 
AGTTCCAAGG TTCCCGCTGT CACCTCCCTG GTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_066305.2
Translation	MEAPASAQTPHPHEPISFGIDQILNSPDQDSAPAPRGPDGASYLGGPPGGRPGATYPSLPASFAGLGAPFEDAGSYSVNLSLAPAGVIRVPAHRPLPGAVPPPLPSALPAMPSVPTVSSLGGLNFPWMESSRRFVKDRFTAAAALTPFTVTRRIGHPYQNRTPPKRKKPRTSFSRVQICELEKRFHRQKYLASAERAALAKSLKMTDAQVKTWFQNRRTKWRRQTAEEREAERQQASRLMLQLQHDAFQKSLNDSIQPDPLCLHNSSLFALQNLQPWEEDSSKVPAVTSLV

Target ORF information:

RefSeq Version	NM_021025.2
Organism	Homo sapiens(Human)
Definition	Homo sapiens T-cell leukemia homeobox 3 (TLX3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_021025.2

ORF Insert Sequence:

ATGGAGGCGC CCGCCAGCGC GCAGACCCCG CACCCGCACG AGCCCATCAG CTTCGGCATC 
GACCAGATCC TTAACAGCCC GGACCAGGAC AGCGCACCCG CCCCGCGGGG CCCCGACGGC 
GCCAGCTACC TGGGAGGGCC CCCCGGGGGC CGTCCGGGCG CCACATACCC GTCTCTGCCC 
GCCTCCTTTG CGGGCCTCGG CGCGCCCTTC GAGGACGCGG GATCTTACAG TGTGAACCTG 
AGCCTAGCGC CCGCAGGCGT GATCCGGGTG CCGGCGCACA GGCCGCTGCC CGGGGCCGTG 
CCACCGCCTC TGCCAAGCGC GCTACCCGCC ATGCCCTCCG TGCCCACGGT CTCCAGCCTT 
GGCGGTCTCA ATTTCCCCTG GATGGAGAGC AGCCGCCGCT TCGTGAAAGA CCGCTTCACA 
GCGGCGGCCG CACTCACGCC CTTCACCGTG ACCCGGCGCA TCGGCCACCC CTACCAGAAC 
CGGACGCCGC CCAAGCGTAA GAAGCCGCGC ACGTCCTTTT CCCGGGTGCA GATCTGCGAG 
CTGGAAAAGC GCTTCCATCG CCAGAAGTAC CTGGCCTCTG CCGAGAGGGC GGCGCTCGCC 
AAGTCCCTCA AAATGACGGA CGCGCAGGTC AAGACCTGGT TCCAAAACCG GAGGACCAAG 
TGGCGGCGGC AGACGGCGGA GGAGCGGGAG GCGGAGCGGC AGCAGGCGAG CCGGCTCATG 
CTGCAGCTGC AACACGACGC CTTCCAAAAG AGCCTCAACG ACTCCATCCA GCCTGACCCG 
CTCTGTCTGC ACAACTCGTC ACTCTTTGCT CTGCAGAATC TGCAGCCCTG GGAGGAGGAT 
AGTTCCAAGG TTCCCGCTGT CACCTCCCTG GTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TLX3 ( NM_021025.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_066305.2 Homo sapiens T cell leukemia homeobox 3 (TLX3), mRNA.

Price & Availability↑

CloneID	OHu03645
Clone ID Related Accession (Same CDS sequence)	NM_021025.2 , NM_021025.4 , NM_021025.3
Accession Version	NM_021025.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 876bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-25
Organism	Homo sapiens(human)
Product	T-cell leukemia homeobox protein 3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC091980.4 and BC017291.2. On Nov 22, 2018 this sequence version replaced NM_021025.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC017291.2, BG828093.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN03465403 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000296921.6/ ENSP00000296921.5 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGAGGCGC CCGCCAGCGC GCAGACCCCG CACCCGCACG AGCCCATCAG CTTCGGCATC 
GACCAGATCC TTAACAGCCC GGACCAGGAC AGCGCACCCG CCCCGCGGGG CCCCGACGGC 
GCCAGCTACC TGGGAGGGCC CCCCGGGGGC CGTCCGGGCG CCACATACCC GTCTCTGCCC 
GCCTCCTTTG CGGGCCTCGG CGCGCCCTTC GAGGACGCGG GATCTTACAG TGTGAACCTG 
AGCCTAGCGC CCGCAGGCGT GATCCGGGTG CCGGCGCACA GGCCGCTGCC CGGGGCCGTG 
CCACCGCCTC TGCCAAGCGC GCTACCCGCC ATGCCCTCCG TGCCCACGGT CTCCAGCCTT 
GGCGGTCTCA ATTTCCCCTG GATGGAGAGC AGCCGCCGCT TCGTGAAAGA CCGCTTCACA 
GCGGCGGCCG CACTCACGCC CTTCACCGTG ACCCGGCGCA TCGGCCACCC CTACCAGAAC 
CGGACGCCGC CCAAGCGTAA GAAGCCGCGC ACGTCCTTTT CCCGGGTGCA GATCTGCGAG 
CTGGAAAAGC GCTTCCATCG CCAGAAGTAC CTGGCCTCTG CCGAGAGGGC GGCGCTCGCC 
AAGTCCCTCA AAATGACGGA CGCGCAGGTC AAGACCTGGT TCCAAAACCG GAGGACCAAG 
TGGCGGCGGC AGACGGCGGA GGAGCGGGAG GCGGAGCGGC AGCAGGCGAG CCGGCTCATG 
CTGCAGCTGC AACACGACGC CTTCCAAAAG AGCCTCAACG ACTCCATCCA GCCTGACCCG 
CTCTGTCTGC ACAACTCGTC ACTCTTTGCT CTGCAGAATC TGCAGCCCTG GGAGGAGGAT 
AGTTCCAAGG TTCCCGCTGT CACCTCCCTG GTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_066305.2
CDS	119..994
Translation	MEAPASAQTPHPHEPISFGIDQILNSPDQDSAPAPRGPDGASYLGGPPGGRPGATYPSLPASFAGLGAPFEDAGSYSVNLSLAPAGVIRVPAHRPLPGAVPPPLPSALPAMPSVPTVSSLGGLNFPWMESSRRFVKDRFTAAAALTPFTVTRRIGHPYQNRTPPKRKKPRTSFSRVQICELEKRFHRQKYLASAERAALAKSLKMTDAQVKTWFQNRRTKWRRQTAEEREAERQQASRLMLQLQHDAFQKSLNDSIQPDPLCLHNSSLFALQNLQPWEEDSSKVPAVTSLV

Target ORF information:

RefSeq Version	NM_021025.4
Organism	Homo sapiens(human)
Definition	Homo sapiens T cell leukemia homeobox 3 (TLX3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_021025.4

ORF Insert Sequence:

ATGGAGGCGC CCGCCAGCGC GCAGACCCCG CACCCGCACG AGCCCATCAG CTTCGGCATC 
GACCAGATCC TTAACAGCCC GGACCAGGAC AGCGCACCCG CCCCGCGGGG CCCCGACGGC 
GCCAGCTACC TGGGAGGGCC CCCCGGGGGC CGTCCGGGCG CCACATACCC GTCTCTGCCC 
GCCTCCTTTG CGGGCCTCGG CGCGCCCTTC GAGGACGCGG GATCTTACAG TGTGAACCTG 
AGCCTAGCGC CCGCAGGCGT GATCCGGGTG CCGGCGCACA GGCCGCTGCC CGGGGCCGTG 
CCACCGCCTC TGCCAAGCGC GCTACCCGCC ATGCCCTCCG TGCCCACGGT CTCCAGCCTT 
GGCGGTCTCA ATTTCCCCTG GATGGAGAGC AGCCGCCGCT TCGTGAAAGA CCGCTTCACA 
GCGGCGGCCG CACTCACGCC CTTCACCGTG ACCCGGCGCA TCGGCCACCC CTACCAGAAC 
CGGACGCCGC CCAAGCGTAA GAAGCCGCGC ACGTCCTTTT CCCGGGTGCA GATCTGCGAG 
CTGGAAAAGC GCTTCCATCG CCAGAAGTAC CTGGCCTCTG CCGAGAGGGC GGCGCTCGCC 
AAGTCCCTCA AAATGACGGA CGCGCAGGTC AAGACCTGGT TCCAAAACCG GAGGACCAAG 
TGGCGGCGGC AGACGGCGGA GGAGCGGGAG GCGGAGCGGC AGCAGGCGAG CCGGCTCATG 
CTGCAGCTGC AACACGACGC CTTCCAAAAG AGCCTCAACG ACTCCATCCA GCCTGACCCG 
CTCTGTCTGC ACAACTCGTC ACTCTTTGCT CTGCAGAATC TGCAGCCCTG GGAGGAGGAT 
AGTTCCAAGG TTCCCGCTGT CACCTCCCTG GTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TLX3 ( NM_021025.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_066305.2 Homo sapiens T cell leukemia homeobox 3 (TLX3), mRNA.

Price & Availability↑

CloneID	OHu03645
Clone ID Related Accession (Same CDS sequence)	NM_021025.2 , NM_021025.4 , NM_021025.3
Accession Version	NM_021025.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 876bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-12
Organism	Homo sapiens(human)
Product	T-cell leukemia homeobox protein 3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC017291.2 and AC091980.4. On Nov 13, 2015 this sequence version replaced NM_021025.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC017291.2, BG828093.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN03465403 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAGGCGC CCGCCAGCGC GCAGACCCCG CACCCGCACG AGCCCATCAG CTTCGGCATC 
GACCAGATCC TTAACAGCCC GGACCAGGAC AGCGCACCCG CCCCGCGGGG CCCCGACGGC 
GCCAGCTACC TGGGAGGGCC CCCCGGGGGC CGTCCGGGCG CCACATACCC GTCTCTGCCC 
GCCTCCTTTG CGGGCCTCGG CGCGCCCTTC GAGGACGCGG GATCTTACAG TGTGAACCTG 
AGCCTAGCGC CCGCAGGCGT GATCCGGGTG CCGGCGCACA GGCCGCTGCC CGGGGCCGTG 
CCACCGCCTC TGCCAAGCGC GCTACCCGCC ATGCCCTCCG TGCCCACGGT CTCCAGCCTT 
GGCGGTCTCA ATTTCCCCTG GATGGAGAGC AGCCGCCGCT TCGTGAAAGA CCGCTTCACA 
GCGGCGGCCG CACTCACGCC CTTCACCGTG ACCCGGCGCA TCGGCCACCC CTACCAGAAC 
CGGACGCCGC CCAAGCGTAA GAAGCCGCGC ACGTCCTTTT CCCGGGTGCA GATCTGCGAG 
CTGGAAAAGC GCTTCCATCG CCAGAAGTAC CTGGCCTCTG CCGAGAGGGC GGCGCTCGCC 
AAGTCCCTCA AAATGACGGA CGCGCAGGTC AAGACCTGGT TCCAAAACCG GAGGACCAAG 
TGGCGGCGGC AGACGGCGGA GGAGCGGGAG GCGGAGCGGC AGCAGGCGAG CCGGCTCATG 
CTGCAGCTGC AACACGACGC CTTCCAAAAG AGCCTCAACG ACTCCATCCA GCCTGACCCG 
CTCTGTCTGC ACAACTCGTC ACTCTTTGCT CTGCAGAATC TGCAGCCCTG GGAGGAGGAT 
AGTTCCAAGG TTCCCGCTGT CACCTCCCTG GTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_066305.2
CDS	83..958
Translation	MEAPASAQTPHPHEPISFGIDQILNSPDQDSAPAPRGPDGASYLGGPPGGRPGATYPSLPASFAGLGAPFEDAGSYSVNLSLAPAGVIRVPAHRPLPGAVPPPLPSALPAMPSVPTVSSLGGLNFPWMESSRRFVKDRFTAAAALTPFTVTRRIGHPYQNRTPPKRKKPRTSFSRVQICELEKRFHRQKYLASAERAALAKSLKMTDAQVKTWFQNRRTKWRRQTAEEREAERQQASRLMLQLQHDAFQKSLNDSIQPDPLCLHNSSLFALQNLQPWEEDSSKVPAVTSLV

Target ORF information:

RefSeq Version	NM_021025.3
Organism	Homo sapiens(human)
Definition	Homo sapiens T cell leukemia homeobox 3 (TLX3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_021025.3

ORF Insert Sequence:

ATGGAGGCGC CCGCCAGCGC GCAGACCCCG CACCCGCACG AGCCCATCAG CTTCGGCATC 
GACCAGATCC TTAACAGCCC GGACCAGGAC AGCGCACCCG CCCCGCGGGG CCCCGACGGC 
GCCAGCTACC TGGGAGGGCC CCCCGGGGGC CGTCCGGGCG CCACATACCC GTCTCTGCCC 
GCCTCCTTTG CGGGCCTCGG CGCGCCCTTC GAGGACGCGG GATCTTACAG TGTGAACCTG 
AGCCTAGCGC CCGCAGGCGT GATCCGGGTG CCGGCGCACA GGCCGCTGCC CGGGGCCGTG 
CCACCGCCTC TGCCAAGCGC GCTACCCGCC ATGCCCTCCG TGCCCACGGT CTCCAGCCTT 
GGCGGTCTCA ATTTCCCCTG GATGGAGAGC AGCCGCCGCT TCGTGAAAGA CCGCTTCACA 
GCGGCGGCCG CACTCACGCC CTTCACCGTG ACCCGGCGCA TCGGCCACCC CTACCAGAAC 
CGGACGCCGC CCAAGCGTAA GAAGCCGCGC ACGTCCTTTT CCCGGGTGCA GATCTGCGAG 
CTGGAAAAGC GCTTCCATCG CCAGAAGTAC CTGGCCTCTG CCGAGAGGGC GGCGCTCGCC 
AAGTCCCTCA AAATGACGGA CGCGCAGGTC AAGACCTGGT TCCAAAACCG GAGGACCAAG 
TGGCGGCGGC AGACGGCGGA GGAGCGGGAG GCGGAGCGGC AGCAGGCGAG CCGGCTCATG 
CTGCAGCTGC AACACGACGC CTTCCAAAAG AGCCTCAACG ACTCCATCCA GCCTGACCCG 
CTCTGTCTGC ACAACTCGTC ACTCTTTGCT CTGCAGAATC TGCAGCCCTG GGAGGAGGAT 
AGTTCCAAGG TTCCCGCTGT CACCTCCCTG GTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Immunophenotyping with CD135 and CD117 predicts the FLT3, IL-7R and TLX3 gene mutations in childhood T-cell acute leukemia.
Blood cells, molecules & diseases5774-80(2016 Mar)
Noronha EP,Andrade FG,Zampier C,de Andrade CF,Terra-Granado E,Pombo-de-Oliveira MS,

NKX2-5, SIL/TAL and TLX3/HOX11L2 expression in Egyptian pediatric T-cell acute lymphoblastic leukemia.
Asia-Pacific journal of clinical oncology12(1)e1-10(2016 Mar)
Moussa H,Sidhom I

Prediction of DNA binding motifs from 3D models of transcription factors; identifying TLX3 regulated genes.
Nucleic acids research42(22)13500-12(2014 Dec)
Pujato M,Kieken F,Skiles AA,Tapinos N,Fiser A

The effect of TLX3 expression on the prognosis of pediatric T cell acute lymphocytic leukemia--a systematic review.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine35(9)8439-43(2014 Sep)
Ma J,Hua J,Sha Y,Xie Y

TLX homeodomain oncogenes mediate T cell maturation arrest in T-ALL via interaction with ETS1 and suppression of TCR? gene expression.
Cancer cell21(4)563-76(2012 Apr)
Dadi S,Le Noir S,Payet-Bornet D,Lhermitte L,Zacarias-Cabeza J,Bergeron J,Villar?se P,Vachez E,Dik WA,Millien C,Radford I,Verhoeyen E,Cosset FL,Petit A,Ifrah N,Dombret H,Hermine O,Spicuglia S,Langerak AW,Macintyre EA,Nadel B,Ferrier P,Asnafi V

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TLX3 cDNA ORF clone, Homo sapiens(human)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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