B4GALNT3 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	B4GALNT3
Entrez Gene ID	283358
Full Name	beta-1,4-N-acetyl-galactosaminyltransferase 3
General protein information	Preferred Names beta-1,4-N-acetyl-galactosaminyltransferase 3 Names beta-1,4-N-acetylgalactosaminyltransferase 3 B4GalNAcT3 Beta4GalNAc-T3 N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N- acetylgalactosaminyltransferase N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase 2 NGalNAc-T2 beta-1,4-N-acetyl-galactosaminyl transferase 3 beta-1,4-N-acetylgalactosaminyltransferase III beta4GalNAcT3
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 12 Map Location: 12p13.33
Summary	B4GALNT3 transfers N-acetylgalactosamine (GalNAc) onto glucosyl residues to form N,N-prime-diacetyllactosediamine (LacdiNAc, or LDN), a unique terminal structure of cell surface N-glycans (Ikehara et al., 2006 [PubMed 16728562]).[supplied by OMIM, Aug 2008].
Disorder MIM:	612220

mRNA and Protein(s)

mRNA	Protein	Name
NM_173593.3	NP_775864.3	beta-1,4-N-acetylgalactosaminyltransferase 3
NM_173593.4	NP_775864.3	beta-1,4-N-acetylgalactosaminyltransferase 3

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	B4GALNT3	XP_508918.2
Homo sapiens (human)	B4GALNT3	NP_775864.3
Gallus gallus (chicken)	B4GALNT3	XP_416381.4
Danio rerio (zebrafish)	b4galnt3b	XP_001342883.4
	B4GALNT3	XP_001094974.1
Bos taurus (cattle)	B4GALNT3	NP_001193624.1
Mus musculus (house mouse)	B4galnt3	NP_942585.1
Rattus norvegicus (Norway rat)	B4galnt3	NP_001178905.1
Canis lupus familiaris (dog)	B4GALNT3	XP_543878.2
Xenopus tropicalis (tropical clawed frog)	b4galnt3	XP_004912790.1

Gene Ontology
Bibliography

Related articles in PubMed

New somatic mutations and WNK1-B4GALNT3 gene fusion in papillary thyroid carcinoma.
Costa V, Esposito R, Ziviello C, Sepe R, Bim LV, Cacciola NA, Decaussin-Petrucci M, Pallante P, Fusco A, Ciccodicola A
Oncotarget6(13)11242-51(2015 May)

?1, 4-N-acetylgalactosaminyltransferase III modulates cancer stemness through EGFR signaling pathway in colon cancer cells.
Che MI, Huang J, Hung JS, Lin YC, Huang MJ, Lai HS, Hsu WM, Liang JT, Huang MC
Oncotarget5(11)3673-84(2014 Jun)

Molecular basis for protein-specific transfer of N-acetylgalactosamine to N-linked glycans by the glycosyltransferases ?1,4-N-acetylgalactosaminyl transferase 3 (?4GalNAc-T3) and ?4GalNAc-T4.
Fiete D, Beranek M, Baenziger JU
The Journal of biological chemistry287(34)29194-203(2012 Aug)

Peptide-specific transfer of N-acetylgalactosamine to O-linked glycans by the glycosyltransferases ?1,4-N-acetylgalactosaminyl transferase 3 (?4GalNAc-T3) and ?4GalNAc-T4.
Fiete D, Beranek M, Baenziger JU
The Journal of biological chemistry287(34)29204-12(2012 Aug)

Genome-wide association study identifies GPC5 as a novel genetic locus protective against sudden cardiac arrest.
Arking DE, Reinier K, Post W, Jui J, Hilton G, O'Connor A, Prineas RJ, Boerwinkle E, Psaty BM, Tomaselli GF, Rea T, Sotoodehnia N, Siscovick DS, Burke GL, Marban E, Spooner PM, Chakravarti A, Chugh SS
PloS one5(3)e9879(2010 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Identify a new chimeric transcript generated by the fusion of WNK1 and B4GALNT3 genes, correlated with B4GALNT3 overexpression papillary thyroid carcinoma.
Title: New somatic mutations and WNK1-B4GALNT3 gene fusion in papillary thyroid carcinoma.

Data suggest B4GALNT3 regulates cancer stemness and the invasive properties of colon cancer cells through modifying EGFR glycosylation and signaling.
Title: ?1, 4-N-acetylgalactosaminyltransferase III modulates cancer stemness through EGFR signaling pathway in colon cancer cells.

Molecular basis for protein-specific transfer of N-acetylgalactosamine to N-linked glycans by the glycosyltransferases beta1,4-N-acetylgalactosaminyl transferase 3 (beta4GalNAc-T3) and beta4GalNAc-T4.
Title: Molecular basis for protein-specific transfer of N-acetylgalactosamine to N-linked glycans by the glycosyltransferases ?1,4-N-acetylgalactosaminyl transferase 3 (?4GalNAc-T3) and ?4GalNAc-T4.

Peptide-specific transfer of N-acetylgalactosamine to O-linked glycans by the glycosyltransferases beta1,4-N-acetylgalactosaminyl transferase 3 (beta4GalNAc-T3) and beta4GalNAc-T4.
Title: Peptide-specific transfer of N-acetylgalactosamine to O-linked glycans by the glycosyltransferases ?1,4-N-acetylgalactosaminyl transferase 3 (?4GalNAc-T3) and ?4GalNAc-T4.

Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.

The following B4GALNT3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the B4GALNT3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu07318	NM_173593.4 Latest version!	Homo sapiens beta-1,4-N-acetyl-galactosaminyltransferase 3 (B4GALNT3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$339.50-$475.30 $679.00
View Old Accession Versions >>
OHu07318	NM_173593.3	Homo sapiens beta-1,4-N-acetyl-galactosaminyltransferase 3 (B4GALNT3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$657.30 $939.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

B4GALNT3 ( NM_173593.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_775864.3 Homo sapiens beta-1,4-N-acetyl-galactosaminyltransferase 3 (B4GALNT3), mRNA.

Price & Availability↑

CloneID	OHu07318
Clone ID Related Accession (Same CDS sequence)	NM_173593.3 , NM_173593.4
Accession Version	NM_173593.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2997bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-31
Organism	Homo sapiens(human)
Product	beta-1,4-N-acetylgalactosaminyltransferase 3
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC005844.8, AB089940.1, CN400443.1, AK093503.1, AK131277.1 and AC006205.9. On May 17, 2019 this sequence version replaced NM_173593.3. ##Evidence-Data-START## Transcript exon combination :: AB089940.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968189, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000266383.10/ ENSP00000266383.5 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##

ATGGGGAGCC CCCGGGCCGC GCGGCCCCCG CTGCTCCTGC GCCCGGTGAA GCTGCTGCGG 
AGGCGCTTCC GGCTGCTGCT GGCGCTCGCC GTGGTGTCTG TGGGGCTCTG GACTCTGTAT 
CTGGAACTGG TGGCGTCGGC CCAGGTCGGC GGGAACCCCC TGAACCGGAG GTACGGCAGC 
TGGAGAGAAC TGGCCAAGGC TCTGGCCAGC AGGAACATTC CAGCTGTGGA TCCACACCTC 
CAGTTCTACC ATCCCCAGAG GCTGAGCCTC GAGGACCACG ACATTGACCA AGGGGTGAGC 
AGTAACAGCA GCTACTTGAA GTGGAACAAG CCTGTCCCCT GGCTCTCAGA GTTCCGGGGC 
CGTGCCAACC TGCATGTGTT TGAAGACTGG TGTGGCAGCT CTATCCAGCA GCTCAGGAGG 
AACCTGCATT TCCCACTGTA CCCCCATATT CGCACAACCC TGAGGAAGCT TGCTGTGTCC 
CCCAAATGGA CCAACTATGG CCTCCGCATC TTTGGCTACC TGCACCCCTT TACTGATGGG 
AAAATCCAGT TTGCCATTGC TGCAGATGAC AACGCGGAGT TCTGGCTGAG CCTCGATGAC 
CAGGTCTCAG GCCTCCAGCT GCTGGCCAGT GTGGGCAAGA CTGGAAAGGA GTGGACCGCC 
CCGGGAGAGT TTGGGAAATT TCGGAGCCAA ATTTCCAAGC CGGTGAGCCT GTCAGCCTCC 
CACAGGTACT ACTTCGAGGT GCTGCACAAG CAGAATGAGG AGGGCACCGA CCACGTGGAA 
GTTGCATGGC GACGGAACGA CCCTGGAGCC AAGTTCACCA TCATTGACTC CCTCTCCCTG 
TCCCTCTTCA CAAATGAGAC GTTCCTACAG ATGGATGAGG TGGGCCACAT CCCACAGACA 
GCAGCCAGCC ACGTGGACTC CTCCAACGCT CTTCCCAGGG ATGAGCAGCC GCCCGCTGAC 
ATGCTTCGGC CTGACCCCCG GGACACCCTC TATCGAGTGC CTCTGATCCC CAAGTCGCAT 
CTCCGCCACG TCCTGCCTGA CTGTCCCTAC AAACCCAGCT ATCTGGTGGA TGGGCTTCCT 
CTGCAGCGCT ACCAGGGACT CCGGTTTGTT CATCTGTCTT TTGTTTACCC CAATGACTAT 
ACCCGCCTGA GCCACATGGA GACCCACAAT AAATGTTTCT ACCAGGAAAA CGCCTACTAC 
CAAGACCGGT TCAGCTTTCA GGAGTACATC AAGATTGACC AGCCTGAGAA GCAGGGGCTG 
GAGCAGCCAG GTTTTGAGGA AAACCTTCTA GAAGAGTCCC AGTATGGGGA AGTGGCAGAG 
GAGACCCCTG CCTCCAACAA CCAGAATGCC AGGATGCTTG AGGGAAGACA GACACCTGCC 
TCCACCCTGG AGCAAGATGC CACTGACTAC CGCCTCCGAA GCCTGCGGAA ACTCCTGGCT 
CAGCCCCGGG AGGGCCTGCT GGCCCCCTTC TCCAAGCGGA ACTCCACAGC GTCCTTCCCA 
GGGAGGACCA GCCACATTCC AGTGCAGCAG CCAGAGAAGA GGAAGCAAAA ACCCAGCCCT 
GAGCCCAGCC AAGATTCACC TCATTCCGAC AAGTGGCCTC CTGGGCACCC TGTGAAGAAC 
CTGCCTCAGA TGAGGGGGCC CAGGCCCAGG CCCGCTGGTG ACAGCCCCAG GAAGACTCAG 
TGGCTGAACC AGGTGGAGTC GTACATCGCA GAGCAGAGAC GGGGTGACAG GATGCGGCCT 
CAGGCCCCTG GAAGGGGCTG GCATGGGGAG GAGGAAGTGG TGGCGGCCGC AGGCCAGGAA 
GGACAAGTGG AGGGAGAGGA AGAGGGGGAA GAAGAGGAGG AGGAAGAGGA TATGAGTGAG 
GTGTTCGAGT ACGTACCTGT GTTTGACCCG GTAGTAAACT GGGACCAGAC CTTCAGTGCC 
CGGAATCTCG ACTTCCAAGC CCTGAGGACT GACTGGATCG ATCTGAGCTG TAACACATCT 
GGCAACCTGC TGCTTCCAGA GCAGGAAGCT CTGGAGGTCA CGCGAGTCTT CTTGAAGAAG 
CTCAACCAGA GGAGCCGGGG GAGGTACCAG CTACAGCGCA TTGTGAACGT GGAAAAGCGT 
CAGGACCAGC TACGTGGGGG TCGCTACCTC CTGGAGCTTG AACTGTTGGA ACAAGGCCAG 
CGCGTGGTGC GGCTCTCGGA GTATGTGTCT GCACGAGGCT GGCAGGGCAT CGATCCAGCT 
GGTGGGGAGG AGGTCGAGGC CCGGAACCTG CAAGGCCTGG TCTGGGACCC ACACAACCGT 
AGGAGACAGG TCCTGAATAC CCGGGCCCAA GAGCCCAAGC TGTGCTGGCC TCAGGGTTTC 
TCCTGGAGTC ACCGAGCCGT GGTCCACTTC GTCGTGCCTG TGAAGAACCA GGCACGCTGG 
GTACAGCAAT TCATCAAAGA CATGGAAAAC CTGTTCCAGG TCACCGGTGA CCCACACTTC 
AACATCGTCA TCACTGACTA TAGCAGTGAG GACATGGATG TTGAGATGGC ACTGAAGAGG 
TCCAAGCTGC GGAGCTACCA GTACGTGAAG CTAAGTGGAA ACTTTGAACG CTCAGCTGGA 
CTTCAGGCTG GCATAGACCT CGTGAAGGAC CCGCACAGCA TCATCTTCCT CTGTGACCTC 
CACATCCACT TCCCAGCTGG AGTCATCGAT GCCATTCGGA AGCACTGTGT GGAGGGAAAG 
ATGGCCTTTG CCCCCATGGT GATGAGGCTG CATTGTGGGG CCACCCCCCA GTGGCCTGAG 
GGCTACTGGG AGGTGAATGG GTTCGGGCTG CTTGGCATCT ACAAGTCTGA CCTGGACAGG 
ATTGGGGGCA TGAACACCAA GGAGTTCCGA GACCGCTGGG GCGGGGAAGA CTGGGAGCTG 
CTGGACAGGA TACTCCAAGC GGGCCTGGAC GTGGAGCGTC TCTCCCTCAG GAATTTCTTC 
CATCATTTCC ATTCCAAGCG AGGCATGTGG AGCCGTCGCC AGATGAAGAC GCTGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_775864.3
CDS	439..3435
Translation	MGSPRAARPPLLLRPVKLLRRRFRLLLALAVVSVGLWTLYLELVASAQVGGNPLNRRYGSWRELAKALASRNIPAVDPHLQFYHPQRLSLEDHDIDQGVSSNSSYLKWNKPVPWLSEFRGRANLHVFEDWCGSSIQQLRRNLHFPLYPHIRTTLRKLAVSPKWTNYGLRIFGYLHPFTDGKIQFAIAADDNAEFWLSLDDQVSGLQLLASVGKTGKEWTAPGEFGKFRSQISKPVSLSASHRYYFEVLHKQNEEGTDHVEVAWRRNDPGAKFTIIDSLSLSLFTNETFLQMDEVGHIPQTAASHVDSSNALPRDEQPPADMLRPDPRDTLYRVPLIPKSHLRHVLPDCPYKPSYLVDGLPLQRYQGLRFVHLSFVYPNDYTRLSHMETHNKCFYQENAYYQDRFSFQEYIKIDQPEKQGLEQPGFEENLLEESQYGEVAEETPASNNQNARMLEGRQTPASTLEQDATDYRLRSLRKLLAQPREGLLAPFSKRNSTASFPGRTSHIPVQQPEKRKQKPSPEPSQDSPHSDKWPPGHPVKNLPQMRGPRPRPAGDSPRKTQWLNQVESYIAEQRRGDRMRPQAPGRGWHGEEEVVAAAGQEGQVEGEEEGEEEEEEEDMSEVFEYVPVFDPVVNWDQTFSARNLDFQALRTDWIDLSCNTSGNLLLPEQEALEVTRVFLKKLNQRSRGRYQLQRIVNVEKRQDQLRGGRYLLELELLEQGQRVVRLSEYVSARGWQGIDPAGGEEVEARNLQGLVWDPHNRRRQVLNTRAQEPKLCWPQGFSWSHRAVVHFVVPVKNQARWVQQFIKDMENLFQVTGDPHFNIVITDYSSEDMDVEMALKRSKLRSYQYVKLSGNFERSAGLQAGIDLVKDPHSIIFLCDLHIHFPAGVIDAIRKHCVEGKMAFAPMVMRLHCGATPQWPEGYWEVNGFGLLGIYKSDLDRIGGMNTKEFRDRWGGEDWELLDRILQAGLDVERLSLRNFFHHFHSKRGMWSRRQMKTL

Target ORF information:

RefSeq Version	NM_173593.4
Organism	Homo sapiens(human)
Definition	Homo sapiens beta-1,4-N-acetyl-galactosaminyltransferase 3 (B4GALNT3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_173593.4

ORF Insert Sequence:

ATGGGGAGCC CCCGGGCCGC GCGGCCCCCG CTGCTCCTGC GCCCGGTGAA GCTGCTGCGG 
AGGCGCTTCC GGCTGCTGCT GGCGCTCGCC GTGGTGTCTG TGGGGCTCTG GACTCTGTAT 
CTGGAACTGG TGGCGTCGGC CCAGGTCGGC GGGAACCCCC TGAACCGGAG GTACGGCAGC 
TGGAGAGAAC TGGCCAAGGC TCTGGCCAGC AGGAACATTC CAGCTGTGGA TCCACACCTC 
CAGTTCTACC ATCCCCAGAG GCTGAGCCTC GAGGACCACG ACATTGACCA AGGGGTGAGC 
AGTAACAGCA GCTACTTGAA GTGGAACAAG CCTGTCCCCT GGCTCTCAGA GTTCCGGGGC 
CGTGCCAACC TGCATGTGTT TGAAGACTGG TGTGGCAGCT CTATCCAGCA GCTCAGGAGG 
AACCTGCATT TCCCACTGTA CCCCCATATT CGCACAACCC TGAGGAAGCT TGCTGTGTCC 
CCCAAATGGA CCAACTATGG CCTCCGCATC TTTGGCTACC TGCACCCCTT TACTGATGGG 
AAAATCCAGT TTGCCATTGC TGCAGATGAC AACGCGGAGT TCTGGCTGAG CCTCGATGAC 
CAGGTCTCAG GCCTCCAGCT GCTGGCCAGT GTGGGCAAGA CTGGAAAGGA GTGGACCGCC 
CCGGGAGAGT TTGGGAAATT TCGGAGCCAA ATTTCCAAGC CGGTGAGCCT GTCAGCCTCC 
CACAGGTACT ACTTCGAGGT GCTGCACAAG CAGAATGAGG AGGGCACCGA CCACGTGGAA 
GTTGCATGGC GACGGAACGA CCCTGGAGCC AAGTTCACCA TCATTGACTC CCTCTCCCTG 
TCCCTCTTCA CAAATGAGAC GTTCCTACAG ATGGATGAGG TGGGCCACAT CCCACAGACA 
GCAGCCAGCC ACGTGGACTC CTCCAACGCT CTTCCCAGGG ATGAGCAGCC GCCCGCTGAC 
ATGCTTCGGC CTGACCCCCG GGACACCCTC TATCGAGTGC CTCTGATCCC CAAGTCGCAT 
CTCCGCCACG TCCTGCCTGA CTGTCCCTAC AAACCCAGCT ATCTGGTGGA TGGGCTTCCT 
CTGCAGCGCT ACCAGGGACT CCGGTTTGTT CATCTGTCTT TTGTTTACCC CAATGACTAT 
ACCCGCCTGA GCCACATGGA GACCCACAAT AAATGTTTCT ACCAGGAAAA CGCCTACTAC 
CAAGACCGGT TCAGCTTTCA GGAGTACATC AAGATTGACC AGCCTGAGAA GCAGGGGCTG 
GAGCAGCCAG GTTTTGAGGA AAACCTTCTA GAAGAGTCCC AGTATGGGGA AGTGGCAGAG 
GAGACCCCTG CCTCCAACAA CCAGAATGCC AGGATGCTTG AGGGAAGACA GACACCTGCC 
TCCACCCTGG AGCAAGATGC CACTGACTAC CGCCTCCGAA GCCTGCGGAA ACTCCTGGCT 
CAGCCCCGGG AGGGCCTGCT GGCCCCCTTC TCCAAGCGGA ACTCCACAGC GTCCTTCCCA 
GGGAGGACCA GCCACATTCC AGTGCAGCAG CCAGAGAAGA GGAAGCAAAA ACCCAGCCCT 
GAGCCCAGCC AAGATTCACC TCATTCCGAC AAGTGGCCTC CTGGGCACCC TGTGAAGAAC 
CTGCCTCAGA TGAGGGGGCC CAGGCCCAGG CCCGCTGGTG ACAGCCCCAG GAAGACTCAG 
TGGCTGAACC AGGTGGAGTC GTACATCGCA GAGCAGAGAC GGGGTGACAG GATGCGGCCT 
CAGGCCCCTG GAAGGGGCTG GCATGGGGAG GAGGAAGTGG TGGCGGCCGC AGGCCAGGAA 
GGACAAGTGG AGGGAGAGGA AGAGGGGGAA GAAGAGGAGG AGGAAGAGGA TATGAGTGAG 
GTGTTCGAGT ACGTACCTGT GTTTGACCCG GTAGTAAACT GGGACCAGAC CTTCAGTGCC 
CGGAATCTCG ACTTCCAAGC CCTGAGGACT GACTGGATCG ATCTGAGCTG TAACACATCT 
GGCAACCTGC TGCTTCCAGA GCAGGAAGCT CTGGAGGTCA CGCGAGTCTT CTTGAAGAAG 
CTCAACCAGA GGAGCCGGGG GAGGTACCAG CTACAGCGCA TTGTGAACGT GGAAAAGCGT 
CAGGACCAGC TACGTGGGGG TCGCTACCTC CTGGAGCTTG AACTGTTGGA ACAAGGCCAG 
CGCGTGGTGC GGCTCTCGGA GTATGTGTCT GCACGAGGCT GGCAGGGCAT CGATCCAGCT 
GGTGGGGAGG AGGTCGAGGC CCGGAACCTG CAAGGCCTGG TCTGGGACCC ACACAACCGT 
AGGAGACAGG TCCTGAATAC CCGGGCCCAA GAGCCCAAGC TGTGCTGGCC TCAGGGTTTC 
TCCTGGAGTC ACCGAGCCGT GGTCCACTTC GTCGTGCCTG TGAAGAACCA GGCACGCTGG 
GTACAGCAAT TCATCAAAGA CATGGAAAAC CTGTTCCAGG TCACCGGTGA CCCACACTTC 
AACATCGTCA TCACTGACTA TAGCAGTGAG GACATGGATG TTGAGATGGC ACTGAAGAGG 
TCCAAGCTGC GGAGCTACCA GTACGTGAAG CTAAGTGGAA ACTTTGAACG CTCAGCTGGA 
CTTCAGGCTG GCATAGACCT CGTGAAGGAC CCGCACAGCA TCATCTTCCT CTGTGACCTC 
CACATCCACT TCCCAGCTGG AGTCATCGAT GCCATTCGGA AGCACTGTGT GGAGGGAAAG 
ATGGCCTTTG CCCCCATGGT GATGAGGCTG CATTGTGGGG CCACCCCCCA GTGGCCTGAG 
GGCTACTGGG AGGTGAATGG GTTCGGGCTG CTTGGCATCT ACAAGTCTGA CCTGGACAGG 
ATTGGGGGCA TGAACACCAA GGAGTTCCGA GACCGCTGGG GCGGGGAAGA CTGGGAGCTG 
CTGGACAGGA TACTCCAAGC GGGCCTGGAC GTGGAGCGTC TCTCCCTCAG GAATTTCTTC 
CATCATTTCC ATTCCAAGCG AGGCATGTGG AGCCGTCGCC AGATGAAGAC GCTGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

B4GALNT3 ( NM_173593.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_775864.3 Homo sapiens beta-1,4-N-acetyl-galactosaminyltransferase 3 (B4GALNT3), mRNA.

Price & Availability↑

CloneID	OHu07318
Clone ID Related Accession (Same CDS sequence)	NM_173593.3 , NM_173593.4
Accession Version	NM_173593.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2997bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-06-22
Organism	Homo sapiens(human)
Product	beta-1,4-N-acetylgalactosaminyltransferase 3
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AB089940.1, CN400443.1, AK093503.1 and AK131277.1. On Jul 20, 2005 this sequence version replaced NM_173593.2. ##Evidence-Data-START## Transcript exon combination :: AB089940.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968189, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END##

ATGGGGAGCC CCCGGGCCGC GCGGCCCCCG CTGCTCCTGC GCCCGGTGAA GCTGCTGCGG 
AGGCGCTTCC GGCTGCTGCT GGCGCTCGCC GTGGTGTCTG TGGGGCTCTG GACTCTGTAT 
CTGGAACTGG TGGCGTCGGC CCAGGTCGGC GGGAACCCCC TGAACCGGAG GTACGGCAGC 
TGGAGAGAAC TGGCCAAGGC TCTGGCCAGC AGGAACATTC CAGCTGTGGA TCCACACCTC 
CAGTTCTACC ATCCCCAGAG GCTGAGCCTC GAGGACCACG ACATTGACCA AGGGGTGAGC 
AGTAACAGCA GCTACTTGAA GTGGAACAAG CCTGTCCCCT GGCTCTCAGA GTTCCGGGGC 
CGTGCCAACC TGCATGTGTT TGAAGACTGG TGTGGCAGCT CTATCCAGCA GCTCAGGAGG 
AACCTGCATT TCCCACTGTA CCCCCATATT CGCACAACCC TGAGGAAGCT TGCTGTGTCC 
CCCAAATGGA CCAACTATGG CCTCCGCATC TTTGGCTACC TGCACCCCTT TACTGATGGG 
AAAATCCAGT TTGCCATTGC TGCAGATGAC AACGCGGAGT TCTGGCTGAG CCTCGATGAC 
CAGGTCTCAG GCCTCCAGCT GCTGGCCAGT GTGGGCAAGA CTGGAAAGGA GTGGACCGCC 
CCGGGAGAGT TTGGGAAATT TCGGAGCCAA ATTTCCAAGC CGGTGAGCCT GTCAGCCTCC 
CACAGGTACT ACTTCGAGGT GCTGCACAAG CAGAATGAGG AGGGCACCGA CCACGTGGAA 
GTTGCATGGC GACGGAACGA CCCTGGAGCC AAGTTCACCA TCATTGACTC CCTCTCCCTG 
TCCCTCTTCA CAAATGAGAC GTTCCTACAG ATGGATGAGG TGGGCCACAT CCCACAGACA 
GCAGCCAGCC ACGTGGACTC CTCCAACGCT CTTCCCAGGG ATGAGCAGCC GCCCGCTGAC 
ATGCTTCGGC CTGACCCCCG GGACACCCTC TATCGAGTGC CTCTGATCCC CAAGTCGCAT 
CTCCGCCACG TCCTGCCTGA CTGTCCCTAC AAACCCAGCT ATCTGGTGGA TGGGCTTCCT 
CTGCAGCGCT ACCAGGGACT CCGGTTTGTT CATCTGTCTT TTGTTTACCC CAATGACTAT 
ACCCGCCTGA GCCACATGGA GACCCACAAT AAATGTTTCT ACCAGGAAAA CGCCTACTAC 
CAAGACCGGT TCAGCTTTCA GGAGTACATC AAGATTGACC AGCCTGAGAA GCAGGGGCTG 
GAGCAGCCAG GTTTTGAGGA AAACCTTCTA GAAGAGTCCC AGTATGGGGA AGTGGCAGAG 
GAGACCCCTG CCTCCAACAA CCAGAATGCC AGGATGCTTG AGGGAAGACA GACACCTGCC 
TCCACCCTGG AGCAAGATGC CACTGACTAC CGCCTCCGAA GCCTGCGGAA ACTCCTGGCT 
CAGCCCCGGG AGGGCCTGCT GGCCCCCTTC TCCAAGCGGA ACTCCACAGC GTCCTTCCCA 
GGGAGGACCA GCCACATTCC AGTGCAGCAG CCAGAGAAGA GGAAGCAAAA ACCCAGCCCT 
GAGCCCAGCC AAGATTCACC TCATTCCGAC AAGTGGCCTC CTGGGCACCC TGTGAAGAAC 
CTGCCTCAGA TGAGGGGGCC CAGGCCCAGG CCCGCTGGTG ACAGCCCCAG GAAGACTCAG 
TGGCTGAACC AGGTGGAGTC GTACATCGCA GAGCAGAGAC GGGGTGACAG GATGCGGCCT 
CAGGCCCCTG GAAGGGGCTG GCATGGGGAG GAGGAAGTGG TGGCGGCCGC AGGCCAGGAA 
GGACAAGTGG AGGGAGAGGA AGAGGGGGAA GAAGAGGAGG AGGAAGAGGA TATGAGTGAG 
GTGTTCGAGT ACGTACCTGT GTTTGACCCG GTAGTAAACT GGGACCAGAC CTTCAGTGCC 
CGGAATCTCG ACTTCCAAGC CCTGAGGACT GACTGGATCG ATCTGAGCTG TAACACATCT 
GGCAACCTGC TGCTTCCAGA GCAGGAAGCT CTGGAGGTCA CGCGAGTCTT CTTGAAGAAG 
CTCAACCAGA GGAGCCGGGG GAGGTACCAG CTACAGCGCA TTGTGAACGT GGAAAAGCGT 
CAGGACCAGC TACGTGGGGG TCGCTACCTC CTGGAGCTTG AACTGTTGGA ACAAGGCCAG 
CGCGTGGTGC GGCTCTCGGA GTATGTGTCT GCACGAGGCT GGCAGGGCAT CGATCCAGCT 
GGTGGGGAGG AGGTCGAGGC CCGGAACCTG CAAGGCCTGG TCTGGGACCC ACACAACCGT 
AGGAGACAGG TCCTGAATAC CCGGGCCCAA GAGCCCAAGC TGTGCTGGCC TCAGGGTTTC 
TCCTGGAGTC ACCGAGCCGT GGTCCACTTC GTCGTGCCTG TGAAGAACCA GGCACGCTGG 
GTACAGCAAT TCATCAAAGA CATGGAAAAC CTGTTCCAGG TCACCGGTGA CCCACACTTC 
AACATCGTCA TCACTGACTA TAGCAGTGAG GACATGGATG TTGAGATGGC ACTGAAGAGG 
TCCAAGCTGC GGAGCTACCA GTACGTGAAG CTAAGTGGAA ACTTTGAACG CTCAGCTGGA 
CTTCAGGCTG GCATAGACCT CGTGAAGGAC CCGCACAGCA TCATCTTCCT CTGTGACCTC 
CACATCCACT TCCCAGCTGG AGTCATCGAT GCCATTCGGA AGCACTGTGT GGAGGGAAAG 
ATGGCCTTTG CCCCCATGGT GATGAGGCTG CATTGTGGGG CCACCCCCCA GTGGCCTGAG 
GGCTACTGGG AGGTGAATGG GTTCGGGCTG CTTGGCATCT ACAAGTCTGA CCTGGACAGG 
ATTGGGGGCA TGAACACCAA GGAGTTCCGA GACCGCTGGG GCGGGGAAGA CTGGGAGCTG 
CTGGACAGGA TACTCCAAGC GGGCCTGGAC GTGGAGCGTC TCTCCCTCAG GAATTTCTTC 
CATCATTTCC ATTCCAAGCG AGGCATGTGG AGCCGTCGCC AGATGAAGAC GCTGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_775864.3
CDS	1..2997
Translation	MGSPRAARPPLLLRPVKLLRRRFRLLLALAVVSVGLWTLYLELVASAQVGGNPLNRRYGSWRELAKALASRNIPAVDPHLQFYHPQRLSLEDHDIDQGVSSNSSYLKWNKPVPWLSEFRGRANLHVFEDWCGSSIQQLRRNLHFPLYPHIRTTLRKLAVSPKWTNYGLRIFGYLHPFTDGKIQFAIAADDNAEFWLSLDDQVSGLQLLASVGKTGKEWTAPGEFGKFRSQISKPVSLSASHRYYFEVLHKQNEEGTDHVEVAWRRNDPGAKFTIIDSLSLSLFTNETFLQMDEVGHIPQTAASHVDSSNALPRDEQPPADMLRPDPRDTLYRVPLIPKSHLRHVLPDCPYKPSYLVDGLPLQRYQGLRFVHLSFVYPNDYTRLSHMETHNKCFYQENAYYQDRFSFQEYIKIDQPEKQGLEQPGFEENLLEESQYGEVAEETPASNNQNARMLEGRQTPASTLEQDATDYRLRSLRKLLAQPREGLLAPFSKRNSTASFPGRTSHIPVQQPEKRKQKPSPEPSQDSPHSDKWPPGHPVKNLPQMRGPRPRPAGDSPRKTQWLNQVESYIAEQRRGDRMRPQAPGRGWHGEEEVVAAAGQEGQVEGEEEGEEEEEEEDMSEVFEYVPVFDPVVNWDQTFSARNLDFQALRTDWIDLSCNTSGNLLLPEQEALEVTRVFLKKLNQRSRGRYQLQRIVNVEKRQDQLRGGRYLLELELLEQGQRVVRLSEYVSARGWQGIDPAGGEEVEARNLQGLVWDPHNRRRQVLNTRAQEPKLCWPQGFSWSHRAVVHFVVPVKNQARWVQQFIKDMENLFQVTGDPHFNIVITDYSSEDMDVEMALKRSKLRSYQYVKLSGNFERSAGLQAGIDLVKDPHSIIFLCDLHIHFPAGVIDAIRKHCVEGKMAFAPMVMRLHCGATPQWPEGYWEVNGFGLLGIYKSDLDRIGGMNTKEFRDRWGGEDWELLDRILQAGLDVERLSLRNFFHHFHSKRGMWSRRQMKTL

Target ORF information:

RefSeq Version	NM_173593.3
Organism	Homo sapiens(human)
Definition	Homo sapiens beta-1,4-N-acetyl-galactosaminyltransferase 3 (B4GALNT3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_173593.3

ORF Insert Sequence:

ATGGGGAGCC CCCGGGCCGC GCGGCCCCCG CTGCTCCTGC GCCCGGTGAA GCTGCTGCGG 
AGGCGCTTCC GGCTGCTGCT GGCGCTCGCC GTGGTGTCTG TGGGGCTCTG GACTCTGTAT 
CTGGAACTGG TGGCGTCGGC CCAGGTCGGC GGGAACCCCC TGAACCGGAG GTACGGCAGC 
TGGAGAGAAC TGGCCAAGGC TCTGGCCAGC AGGAACATTC CAGCTGTGGA TCCACACCTC 
CAGTTCTACC ATCCCCAGAG GCTGAGCCTC GAGGACCACG ACATTGACCA AGGGGTGAGC 
AGTAACAGCA GCTACTTGAA GTGGAACAAG CCTGTCCCCT GGCTCTCAGA GTTCCGGGGC 
CGTGCCAACC TGCATGTGTT TGAAGACTGG TGTGGCAGCT CTATCCAGCA GCTCAGGAGG 
AACCTGCATT TCCCACTGTA CCCCCATATT CGCACAACCC TGAGGAAGCT TGCTGTGTCC 
CCCAAATGGA CCAACTATGG CCTCCGCATC TTTGGCTACC TGCACCCCTT TACTGATGGG 
AAAATCCAGT TTGCCATTGC TGCAGATGAC AACGCGGAGT TCTGGCTGAG CCTCGATGAC 
CAGGTCTCAG GCCTCCAGCT GCTGGCCAGT GTGGGCAAGA CTGGAAAGGA GTGGACCGCC 
CCGGGAGAGT TTGGGAAATT TCGGAGCCAA ATTTCCAAGC CGGTGAGCCT GTCAGCCTCC 
CACAGGTACT ACTTCGAGGT GCTGCACAAG CAGAATGAGG AGGGCACCGA CCACGTGGAA 
GTTGCATGGC GACGGAACGA CCCTGGAGCC AAGTTCACCA TCATTGACTC CCTCTCCCTG 
TCCCTCTTCA CAAATGAGAC GTTCCTACAG ATGGATGAGG TGGGCCACAT CCCACAGACA 
GCAGCCAGCC ACGTGGACTC CTCCAACGCT CTTCCCAGGG ATGAGCAGCC GCCCGCTGAC 
ATGCTTCGGC CTGACCCCCG GGACACCCTC TATCGAGTGC CTCTGATCCC CAAGTCGCAT 
CTCCGCCACG TCCTGCCTGA CTGTCCCTAC AAACCCAGCT ATCTGGTGGA TGGGCTTCCT 
CTGCAGCGCT ACCAGGGACT CCGGTTTGTT CATCTGTCTT TTGTTTACCC CAATGACTAT 
ACCCGCCTGA GCCACATGGA GACCCACAAT AAATGTTTCT ACCAGGAAAA CGCCTACTAC 
CAAGACCGGT TCAGCTTTCA GGAGTACATC AAGATTGACC AGCCTGAGAA GCAGGGGCTG 
GAGCAGCCAG GTTTTGAGGA AAACCTTCTA GAAGAGTCCC AGTATGGGGA AGTGGCAGAG 
GAGACCCCTG CCTCCAACAA CCAGAATGCC AGGATGCTTG AGGGAAGACA GACACCTGCC 
TCCACCCTGG AGCAAGATGC CACTGACTAC CGCCTCCGAA GCCTGCGGAA ACTCCTGGCT 
CAGCCCCGGG AGGGCCTGCT GGCCCCCTTC TCCAAGCGGA ACTCCACAGC GTCCTTCCCA 
GGGAGGACCA GCCACATTCC AGTGCAGCAG CCAGAGAAGA GGAAGCAAAA ACCCAGCCCT 
GAGCCCAGCC AAGATTCACC TCATTCCGAC AAGTGGCCTC CTGGGCACCC TGTGAAGAAC 
CTGCCTCAGA TGAGGGGGCC CAGGCCCAGG CCCGCTGGTG ACAGCCCCAG GAAGACTCAG 
TGGCTGAACC AGGTGGAGTC GTACATCGCA GAGCAGAGAC GGGGTGACAG GATGCGGCCT 
CAGGCCCCTG GAAGGGGCTG GCATGGGGAG GAGGAAGTGG TGGCGGCCGC AGGCCAGGAA 
GGACAAGTGG AGGGAGAGGA AGAGGGGGAA GAAGAGGAGG AGGAAGAGGA TATGAGTGAG 
GTGTTCGAGT ACGTACCTGT GTTTGACCCG GTAGTAAACT GGGACCAGAC CTTCAGTGCC 
CGGAATCTCG ACTTCCAAGC CCTGAGGACT GACTGGATCG ATCTGAGCTG TAACACATCT 
GGCAACCTGC TGCTTCCAGA GCAGGAAGCT CTGGAGGTCA CGCGAGTCTT CTTGAAGAAG 
CTCAACCAGA GGAGCCGGGG GAGGTACCAG CTACAGCGCA TTGTGAACGT GGAAAAGCGT 
CAGGACCAGC TACGTGGGGG TCGCTACCTC CTGGAGCTTG AACTGTTGGA ACAAGGCCAG 
CGCGTGGTGC GGCTCTCGGA GTATGTGTCT GCACGAGGCT GGCAGGGCAT CGATCCAGCT 
GGTGGGGAGG AGGTCGAGGC CCGGAACCTG CAAGGCCTGG TCTGGGACCC ACACAACCGT 
AGGAGACAGG TCCTGAATAC CCGGGCCCAA GAGCCCAAGC TGTGCTGGCC TCAGGGTTTC 
TCCTGGAGTC ACCGAGCCGT GGTCCACTTC GTCGTGCCTG TGAAGAACCA GGCACGCTGG 
GTACAGCAAT TCATCAAAGA CATGGAAAAC CTGTTCCAGG TCACCGGTGA CCCACACTTC 
AACATCGTCA TCACTGACTA TAGCAGTGAG GACATGGATG TTGAGATGGC ACTGAAGAGG 
TCCAAGCTGC GGAGCTACCA GTACGTGAAG CTAAGTGGAA ACTTTGAACG CTCAGCTGGA 
CTTCAGGCTG GCATAGACCT CGTGAAGGAC CCGCACAGCA TCATCTTCCT CTGTGACCTC 
CACATCCACT TCCCAGCTGG AGTCATCGAT GCCATTCGGA AGCACTGTGT GGAGGGAAAG 
ATGGCCTTTG CCCCCATGGT GATGAGGCTG CATTGTGGGG CCACCCCCCA GTGGCCTGAG 
GGCTACTGGG AGGTGAATGG GTTCGGGCTG CTTGGCATCT ACAAGTCTGA CCTGGACAGG 
ATTGGGGGCA TGAACACCAA GGAGTTCCGA GACCGCTGGG GCGGGGAAGA CTGGGAGCTG 
CTGGACAGGA TACTCCAAGC GGGCCTGGAC GTGGAGCGTC TCTCCCTCAG GAATTTCTTC 
CATCATTTCC ATTCCAAGCG AGGCATGTGG AGCCGTCGCC AGATGAAGAC GCTGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

New somatic mutations and WNK1-B4GALNT3 gene fusion in papillary thyroid carcinoma.
Oncotarget6(13)11242-51(2015 May)
Costa V,Esposito R,Ziviello C,Sepe R,Bim LV,Cacciola NA,Decaussin-Petrucci M,Pallante P,Fusco A,Ciccodicola A

?1, 4-N-acetylgalactosaminyltransferase III modulates cancer stemness through EGFR signaling pathway in colon cancer cells.
Oncotarget5(11)3673-84(2014 Jun)
Che MI,Huang J,Hung JS,Lin YC,Huang MJ,Lai HS,Hsu WM,Liang JT,Huang MC

Molecular basis for protein-specific transfer of N-acetylgalactosamine to N-linked glycans by the glycosyltransferases ?1,4-N-acetylgalactosaminyl transferase 3 (?4GalNAc-T3) and ?4GalNAc-T4.
The Journal of biological chemistry287(34)29194-203(2012 Aug)
Fiete D,Beranek M,Baenziger JU

Peptide-specific transfer of N-acetylgalactosamine to O-linked glycans by the glycosyltransferases ?1,4-N-acetylgalactosaminyl transferase 3 (?4GalNAc-T3) and ?4GalNAc-T4.
The Journal of biological chemistry287(34)29204-12(2012 Aug)
Fiete D,Beranek M,Baenziger JU

Genome-wide association study identifies GPC5 as a novel genetic locus protective against sudden cardiac arrest.
PloS one5(3)e9879(2010 Mar)
Arking DE,Reinier K,Post W,Jui J,Hilton G,O'Connor A,Prineas RJ,Boerwinkle E,Psaty BM,Tomaselli GF,Rea T,Sotoodehnia N,Siscovick DS,Burke GL,Marban E,Spooner PM,Chakravarti A,Chugh SS

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B4GALNT3 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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