CRCP cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	CRCP
Entrez Gene ID	27297
Full Name	CGRP receptor component
Synonyms	CGRP-RCP,CGRPRCP,RCP,RCP9
General protein information	Preferred Names CGRP receptor component Names DNA-directed RNA polymerase III subunit RPC9 CGRP-receptor component protein RNA polymerase III subunit C9 calcitonin gene-related peptide-receptor component protein
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 7 Map Location: 7q11.21
Summary	This gene encodes a membrane protein that functions as part of a receptor complex for a small neuropeptide that increases intracellular cAMP levels. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008].
Disorder MIM:	606121

mRNA and Protein(s)

mRNA	Protein	Name
NM_001040647.1	NP_001035737.1	DNA-directed RNA polymerase III subunit RPC9 isoform b
NM_014478.4	NP_055293.1	DNA-directed RNA polymerase III subunit RPC9 isoform a
NM_014478.5	NP_055293.1	DNA-directed RNA polymerase III subunit RPC9 isoform a
NM_001040648.1	NP_001035738.1	DNA-directed RNA polymerase III subunit RPC9 isoform c
NM_001142414.1	NP_001135886.1	DNA-directed RNA polymerase III subunit RPC9 isoform d

Pathways from BioSystems

Homologies

Homo sapiens (human)	CRCP	NP_055293.1
Rattus norvegicus (Norway rat)	Crcp	NP_446122.1
Canis lupus familiaris (dog)	CRCP	XP_536833.2
Danio rerio (zebrafish)	crcp	NP_001038838.1
Pan troglodytes (chimpanzee)	CRCP	NP_001229358.1
Mus musculus (house mouse)	Crcp	NP_031787.1
Gallus gallus (chicken)	CRCP	XP_415793.1
Drosophila melanogaster (fruit fly)	Rcp	NP_996493.1
Xenopus tropicalis (tropical clawed frog)	crcp	NP_001016478.1
Bos taurus (cattle)	CRCP	NP_001071338.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP007220	XP_308566.3

Gene Ontology
Bibliography

Related articles in PubMed

Receptor Activity-modifying Protein-directed G Protein Signaling Specificity for the Calcitonin Gene-related Peptide Family of Receptors.
Weston C, Winfield I, Harris M, Hodgson R, Shah A, Dowell SJ, Mobarec JC, Woodlock DA, Reynolds CA, Poyner DR, Watkins HA, Ladds G
The Journal of biological chemistry291(42)21925-21944(2016 Oct)

Immunohistochemical localization of the calcitonin gene-related peptide binding site in the primate trigeminovascular system using functional antagonist antibodies.
Miller S, Liu H, Warfvinge K, Shi L, Dovlatyan M, Xu C, Edvinsson L
Neuroscience328165-83(2016 07)

Calcitonin gene related family peptides: importance in normal placental and fetal development.
Yallampalli C, Chauhan M, Endsley J, Sathishkumar K
Advances in experimental medicine and biology814229-40(2014)

Calcitonin gene-related peptide (CGRP) and its receptor components in human and rat spinal trigeminal nucleus and spinal cord at C1-level.
Eftekhari S, Edvinsson L
BMC neuroscience12112(2011 Nov)

Genome-wide joint SNP and CNV analysis of aortic root diameter in African Americans: the HyperGEN study.
Wineinger NE, Patki A, Meyers KJ, Broeckel U, Gu CC, Rao DC, Devereux RB, Arnett DK, Tiwari HK
BMC medical genomics44(2011 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

CGRP family of receptors displays both ligand- and RAMP-dependent signaling bias among the Galphas, Galphai, and Galphaq/11 pathways.
Title: Receptor Activity-modifying Protein-directed G Protein Signaling Specificity for the Calcitonin Gene-related Peptide Family of Receptors.

data reinforce and clarify our understanding of CGRP receptor localization, and provide evidence that antagonist antibodies bind to target sites in the trigeminovascular system of primates that are involved in the pathology of migraine
Title: Immunohistochemical localization of the calcitonin gene-related peptide binding site in the primate trigeminovascular system using functional antagonist antibodies.

In this review, the influence of the CGRP family peptides in reproduction and pregnancy is explored and discussed.
Title: Calcitonin gene related family peptides: importance in normal placental and fetal development.

This study demonstrates the detailed expression of CGRP and its receptor components within spinal trigeminal nucleus in the brainstem and in the spinal cord at C1-level
Title: Calcitonin gene-related peptide (CGRP) and its receptor components in human and rat spinal trigeminal nucleus and spinal cord at C1-level.

Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.

The following CRCP gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CRCP cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu05011	NM_001040647.1 Latest version!	Homo sapiens CGRP receptor component (CRCP), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu30404	NM_014478.5 Latest version!	Homo sapiens CGRP receptor component (CRCP), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu05018	NM_001040648.1 Latest version!	Homo sapiens CGRP receptor component (CRCP), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OHu07517	NM_001142414.1 Latest version!	Homo sapiens CGRP receptor component (CRCP), transcript variant 4, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
View Old Accession Versions >>
OHu30404	NM_014478.4	Homo sapiens CGRP receptor component (CRCP), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CRCP ( NM_001040647.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001035737.1 Homo sapiens CGRP receptor component (CRCP), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu05011
Clone ID Related Accession (Same CDS sequence)	NM_001040647.1
Accession Version	NM_001040647.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 348bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-23
Organism	Homo sapiens(human)
Product	DNA-directed RNA polymerase III subunit RPC9 isoform b
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BI600330.1, BC040107.1, AC068533.7 and BC052570.1. Transcript Variant: This variant (2) lacks an alternate in-frame exon, compared to variant 1, resulting in a shorter protein (isoform b), compared to isoform a. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803616.57648.1, SRR1660803.263177.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAAGTGA AGGATGCCAA TTCTGCGCTT CTCAGTAACT ACGAGACGTT AAAATACATA 
TCAAAAACAC CATGCAGGCA CCAGAGTCCT GAAATTGTCA GAGAATTTCT CACAGCATTG 
AAAAGCCACA AGTTGACCAA AGCTGAGAAG CTCCAGCTGC TGAACCACCG GCCTGTGACT 
GCTGTGGAGA TCCAGCTGAT GGTGGAAGAG AGTGAAGAGC GGCTCACGGA GGAGCAGATT 
GAAGCTCTTC TCCACACCGT CACCAGCATT CTGCCTGCAG AGCCAGAGGC TGAGCAGAAG 
AAGAATACAA ACAGCAATGT GGCAATGGAC GAAGAGGACC CAGCATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001035737.1
CDS	146..493
Translation	MEVKDANSALLSNYETLKYISKTPCRHQSPEIVREFLTALKSHKLTKAEKLQLLNHRPVTAVEIQLMVEESEERLTEEQIEALLHTVTSILPAEPEAEQKKNTNSNVAMDEEDPA

Target ORF information:

RefSeq Version	NM_001040647.1
Organism	Homo sapiens(human)
Definition	Homo sapiens CGRP receptor component (CRCP), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001040647.1

ORF Insert Sequence:

ATGGAAGTGA AGGATGCCAA TTCTGCGCTT CTCAGTAACT ACGAGACGTT AAAATACATA 
TCAAAAACAC CATGCAGGCA CCAGAGTCCT GAAATTGTCA GAGAATTTCT CACAGCATTG 
AAAAGCCACA AGTTGACCAA AGCTGAGAAG CTCCAGCTGC TGAACCACCG GCCTGTGACT 
GCTGTGGAGA TCCAGCTGAT GGTGGAAGAG AGTGAAGAGC GGCTCACGGA GGAGCAGATT 
GAAGCTCTTC TCCACACCGT CACCAGCATT CTGCCTGCAG AGCCAGAGGC TGAGCAGAAG 
AAGAATACAA ACAGCAATGT GGCAATGGAC GAAGAGGACC CAGCATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CRCP ( NM_014478.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_055293.1 Homo sapiens CGRP receptor component (CRCP), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu30404
Clone ID Related Accession (Same CDS sequence)	NM_014478.4 , NM_014478.5
Accession Version	NM_014478.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 447bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	DNA-directed RNA polymerase III subunit RPC9 isoform a
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BI600330.1, BC105808.1, U51134.1, AC068533.7 and BC052570.1. On May 25, 2006 this sequence version replaced NM_014478.3. Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: DA821665.1, SRR1803616.115188.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAAGTGA AGGATGCCAA TTCTGCGCTT CTCAGTAACT ACGAGGTATT TCAGTTACTA 
ACTGATCTGA AAGAGCAGCG TAAAGAAAGT GGAAAGAATA AACACAGCTC TGGGCAACAG 
AACTTGAACA CTATCACCTA TGAAACGTTA AAATACATAT CAAAAACACC ATGCAGGCAC 
CAGAGTCCTG AAATTGTCAG AGAATTTCTC ACAGCATTGA AAAGCCACAA GTTGACCAAA 
GCTGAGAAGC TCCAGCTGCT GAACCACCGG CCTGTGACTG CTGTGGAGAT CCAGCTGATG 
GTGGAAGAGA GTGAAGAGCG GCTCACGGAG GAGCAGATTG AAGCTCTTCT CCACACCGTC 
ACCAGCATTC TGCCTGCAGA GCCAGAGGCT GAGCAGAAGA AGAATACAAA CAGCAATGTG 
GCAATGGACG AAGAGGACCC AGCATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_055293.1
CDS	146..592
Translation	MEVKDANSALLSNYEVFQLLTDLKEQRKESGKNKHSSGQQNLNTITYETLKYISKTPCRHQSPEIVREFLTALKSHKLTKAEKLQLLNHRPVTAVEIQLMVEESEERLTEEQIEALLHTVTSILPAEPEAEQKKNTNSNVAMDEEDPA

Target ORF information:

RefSeq Version	NM_014478.4
Organism	Homo sapiens(human)
Definition	Homo sapiens CGRP receptor component (CRCP), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_014478.4

ORF Insert Sequence:

ATGGAAGTGA AGGATGCCAA TTCTGCGCTT CTCAGTAACT ACGAGGTATT TCAGTTACTA 
ACTGATCTGA AAGAGCAGCG TAAAGAAAGT GGAAAGAATA AACACAGCTC TGGGCAACAG 
AACTTGAACA CTATCACCTA TGAAACGTTA AAATACATAT CAAAAACACC ATGCAGGCAC 
CAGAGTCCTG AAATTGTCAG AGAATTTCTC ACAGCATTGA AAAGCCACAA GTTGACCAAA 
GCTGAGAAGC TCCAGCTGCT GAACCACCGG CCTGTGACTG CTGTGGAGAT CCAGCTGATG 
GTGGAAGAGA GTGAAGAGCG GCTCACGGAG GAGCAGATTG AAGCTCTTCT CCACACCGTC 
ACCAGCATTC TGCCTGCAGA GCCAGAGGCT GAGCAGAAGA AGAATACAAA CAGCAATGTG 
GCAATGGACG AAGAGGACCC AGCATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CRCP ( NM_014478.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_055293.1 Homo sapiens CGRP receptor component (CRCP), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu30404
Clone ID Related Accession (Same CDS sequence)	NM_014478.4 , NM_014478.5
Accession Version	NM_014478.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 447bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-26
Organism	Homo sapiens(human)
Product	DNA-directed RNA polymerase III subunit RPC9 isoform a
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BI600330.1, BC105808.1, U51134.1, AC068533.7 and BC052570.1. On Nov 23, 2018 this sequence version replaced NM_014478.4. Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR3476690.927212.1, SRR1803616.115188.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000395326.8/ ENSP00000378736.3 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGAAGTGA AGGATGCCAA TTCTGCGCTT CTCAGTAACT ACGAGGTATT TCAGTTACTA 
ACTGATCTGA AAGAGCAGCG TAAAGAAAGT GGAAAGAATA AACACAGCTC TGGGCAACAG 
AACTTGAACA CTATCACCTA TGAAACGTTA AAATACATAT CAAAAACACC ATGCAGGCAC 
CAGAGTCCTG AAATTGTCAG AGAATTTCTC ACAGCATTGA AAAGCCACAA GTTGACCAAA 
GCTGAGAAGC TCCAGCTGCT GAACCACCGG CCTGTGACTG CTGTGGAGAT CCAGCTGATG 
GTGGAAGAGA GTGAAGAGCG GCTCACGGAG GAGCAGATTG AAGCTCTTCT CCACACCGTC 
ACCAGCATTC TGCCTGCAGA GCCAGAGGCT GAGCAGAAGA AGAATACAAA CAGCAATGTG 
GCAATGGACG AAGAGGACCC AGCATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_055293.1
CDS	117..563
Translation	MEVKDANSALLSNYEVFQLLTDLKEQRKESGKNKHSSGQQNLNTITYETLKYISKTPCRHQSPEIVREFLTALKSHKLTKAEKLQLLNHRPVTAVEIQLMVEESEERLTEEQIEALLHTVTSILPAEPEAEQKKNTNSNVAMDEEDPA

Target ORF information:

RefSeq Version	NM_014478.5
Organism	Homo sapiens(human)
Definition	Homo sapiens CGRP receptor component (CRCP), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_014478.5

ORF Insert Sequence:

ATGGAAGTGA AGGATGCCAA TTCTGCGCTT CTCAGTAACT ACGAGGTATT TCAGTTACTA 
ACTGATCTGA AAGAGCAGCG TAAAGAAAGT GGAAAGAATA AACACAGCTC TGGGCAACAG 
AACTTGAACA CTATCACCTA TGAAACGTTA AAATACATAT CAAAAACACC ATGCAGGCAC 
CAGAGTCCTG AAATTGTCAG AGAATTTCTC ACAGCATTGA AAAGCCACAA GTTGACCAAA 
GCTGAGAAGC TCCAGCTGCT GAACCACCGG CCTGTGACTG CTGTGGAGAT CCAGCTGATG 
GTGGAAGAGA GTGAAGAGCG GCTCACGGAG GAGCAGATTG AAGCTCTTCT CCACACCGTC 
ACCAGCATTC TGCCTGCAGA GCCAGAGGCT GAGCAGAAGA AGAATACAAA CAGCAATGTG 
GCAATGGACG AAGAGGACCC AGCATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CRCP ( NM_001040648.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001035738.1 Homo sapiens CGRP receptor component (CRCP), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu05018
Clone ID Related Accession (Same CDS sequence)	NM_001040648.1
Accession Version	NM_001040648.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 216bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-22
Organism	Homo sapiens(human)
Product	DNA-directed RNA polymerase III subunit RPC9 isoform c
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BI600330.1, DB472426.1, AC068533.7 and BC052570.1. Transcript Variant: This variant (3) lacks three consecutive exons but maintains the reading frame, compared to variant 1, resulting in a much shorter protein (isoform c), compared to isoform a. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803612.62126.1, SRR1660803.85796.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968189, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAAGTAG CTGAGAAGCT CCAGCTGCTG AACCACCGGC CTGTGACTGC TGTGGAGATC 
CAGCTGATGG TGGAAGAGAG TGAAGAGCGG CTCACGGAGG AGCAGATTGA AGCTCTTCTC 
CACACCGTCA CCAGCATTCT GCCTGCAGAG CCAGAGGCTG AGCAGAAGAA GAATACAAAC 
AGCAATGTGG CAATGGACGA AGAGGACCCA GCATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001035738.1
CDS	146..361
Translation	MEVAEKLQLLNHRPVTAVEIQLMVEESEERLTEEQIEALLHTVTSILPAEPEAEQKKNTNSNVAMDEEDPA

Target ORF information:

RefSeq Version	NM_001040648.1
Organism	Homo sapiens(human)
Definition	Homo sapiens CGRP receptor component (CRCP), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001040648.1

ORF Insert Sequence:

ATGGAAGTAG CTGAGAAGCT CCAGCTGCTG AACCACCGGC CTGTGACTGC TGTGGAGATC 
CAGCTGATGG TGGAAGAGAG TGAAGAGCGG CTCACGGAGG AGCAGATTGA AGCTCTTCTC 
CACACCGTCA CCAGCATTCT GCCTGCAGAG CCAGAGGCTG AGCAGAAGAA GAATACAAAC 
AGCAATGTGG CAATGGACGA AGAGGACCCA GCATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CRCP ( NM_001142414.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001135886.1 Homo sapiens CGRP receptor component (CRCP), transcript variant 4, mRNA.

Price & Availability↑

CloneID	OHu07517
Clone ID Related Accession (Same CDS sequence)	NM_001142414.1
Accession Version	NM_001142414.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 426bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-23
Organism	Homo sapiens(human)
Product	DNA-directed RNA polymerase III subunit RPC9 isoform d
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA821665.1, AK303737.1 and AC068533.7. Transcript Variant: This variant (4) lacks an internal segment in the 5' region, which results in an upstream AUG start codon, and also lacks an exon in the middle region, as compared to variant 1. The reading frame is not affected, and the resulting isoform (d) is shorter and has a distinct N-terminus, as compared to isoform a. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK303737.1, DC354568.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968189, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END##

ATGCAGCGCG GCGATCCCGG CGAGCACCTT GGCGCGCGGA GCTGGCACCT TGGCGCTGTT 
GGTGGCGGCG GAGACAGCTG TGAAGTGAAG GATGCCAATT CTGCGCTTCT CAGTAACTAC 
GAGACGTTAA AATACATATC AAAAACACCA TGCAGGCACC AGAGTCCTGA AATTGTCAGA 
GAATTTCTCA CAGCATTGAA AAGCCACAAG TTGACCAAAG CTGAGAAGCT CCAGCTGCTG 
AACCACCGGC CTGTGACTGC TGTGGAGATC CAGCTGATGG TGGAAGAGAG TGAAGAGCGG 
CTCACGGAGG AGCAGATTGA AGCTCTTCTC CACACCGTCA CCAGCATTCT GCCTGCAGAG 
CCAGAGGCTG AGCAGAAGAA GAATACAAAC AGCAATGTGG CAATGGACGA AGAGGACCCA 
GCATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001135886.1
CDS	12..437
Translation	MQRGDPGEHLGARSWHLGAVGGGGDSCEVKDANSALLSNYETLKYISKTPCRHQSPEIVREFLTALKSHKLTKAEKLQLLNHRPVTAVEIQLMVEESEERLTEEQIEALLHTVTSILPAEPEAEQKKNTNSNVAMDEEDPA

Target ORF information:

RefSeq Version	NM_001142414.1
Organism	Homo sapiens(human)
Definition	Homo sapiens CGRP receptor component (CRCP), transcript variant 4, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001142414.1

ORF Insert Sequence:

ATGCAGCGCG GCGATCCCGG CGAGCACCTT GGCGCGCGGA GCTGGCACCT TGGCGCTGTT 
GGTGGCGGCG GAGACAGCTG TGAAGTGAAG GATGCCAATT CTGCGCTTCT CAGTAACTAC 
GAGACGTTAA AATACATATC AAAAACACCA TGCAGGCACC AGAGTCCTGA AATTGTCAGA 
GAATTTCTCA CAGCATTGAA AAGCCACAAG TTGACCAAAG CTGAGAAGCT CCAGCTGCTG 
AACCACCGGC CTGTGACTGC TGTGGAGATC CAGCTGATGG TGGAAGAGAG TGAAGAGCGG 
CTCACGGAGG AGCAGATTGA AGCTCTTCTC CACACCGTCA CCAGCATTCT GCCTGCAGAG 
CCAGAGGCTG AGCAGAAGAA GAATACAAAC AGCAATGTGG CAATGGACGA AGAGGACCCA 
GCATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Receptor Activity-modifying Protein-directed G Protein Signaling Specificity for the Calcitonin Gene-related Peptide Family of Receptors.
The Journal of biological chemistry291(42)21925-21944(2016 Oct)
Weston C,Winfield I,Harris M,Hodgson R,Shah A,Dowell SJ,Mobarec JC,Woodlock DA,Reynolds CA,Poyner DR,Watkins HA,Ladds G

Immunohistochemical localization of the calcitonin gene-related peptide binding site in the primate trigeminovascular system using functional antagonist antibodies.
Neuroscience328165-83(2016 07)
Miller S,Liu H,Warfvinge K,Shi L,Dovlatyan M,Xu C,Edvinsson L

Calcitonin gene related family peptides: importance in normal placental and fetal development.
Advances in experimental medicine and biology814229-40(2014)
Yallampalli C,Chauhan M,Endsley J,Sathishkumar K

Calcitonin gene-related peptide (CGRP) and its receptor components in human and rat spinal trigeminal nucleus and spinal cord at C1-level.
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CRCP cDNA ORF clone, Homo sapiens(human)

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Clones

gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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