NOC2L cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	NOC2L
Entrez Gene ID	26155
Full Name	NOC2 like nucleolar associated transcriptional repressor
Synonyms	NET15,NET7,NIR,PPP1R112
General protein information	Preferred Names NOC2 like nucleolar associated transcriptional repressor Names nucleolar complex protein 2 homolog NOC2-like protein NOC2L nucleolar associated transcriptional repressor novel INHAT (inhibitor of histone acetyltransferase) repressor novel INHAT repressor nucleolar complex associated 2 homolog protein NOC2 homolog protein phosphatase 1, regulatory subunit 12
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 1 Map Location: 1p36.33
Summary	Histone modification by histone acetyltransferases (HAT) and histone deacetylases (HDAC) can control major aspects of transcriptional regulation. NOC2L represents a novel HDAC-independent inhibitor of histone acetyltransferase (INHAT) (Hublitz et al., 2005 [PubMed 16322561]).[supplied by OMIM, Mar 2008].
Disorder MIM:	610770

mRNA and Protein(s)

mRNA	Protein	Name
NM_015658.3	NP_056473.2	nucleolar complex protein 2 homolog
NM_015658.4	NP_056473.3	nucleolar complex protein 2 homolog

Pathways from BioSystems

Homologies

Homo sapiens (human)	NOC2L	NP_056473.2
Bos taurus (cattle)	NOC2L	NP_001029498.1
Eremothecium gossypii	AGOS_ADL277W	NP_983819.1
Neurospora crassa	NCU02066	XP_964593.1
Arabidopsis thaliana (thale cress)	AT2G18220	NP_179414.2
Xenopus tropicalis (tropical clawed frog)	noc2l	XP_002936424.2
	NOC2L	XP_001089937.2
Gallus gallus (chicken)	NOC2L	NP_001026047.1
Drosophila melanogaster (fruit fly)	CG9246	NP_610095.1
Caenorhabditis elegans (roundworm)	pro-2	NP_496224.1
Saccharomyces cerevisiae (baker's yeast)	NOC2	NP_014849.3
Magnaporthe oryzae (rice blast fungus)	MGG_08867	XP_003713893.1
Danio rerio (zebrafish)	noc2l	NP_001003830.1
Oryza sativa (rice)	Os10g0495500	NP_001064951.2
Pan troglodytes (chimpanzee)	LOC100608665	XP_003318995.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP010536	XP_001237567.2
Schizosaccharomyces pombe (fission yeast)	SPAC1142.04	NP_594268.1
Canis lupus familiaris (dog)	NOC2L	XP_546728.3
Mus musculus (house mouse)	Noc2l	NP_067278.2
Rattus norvegicus (Norway rat)	Noc2l	NP_001029069.1
Kluyveromyces lactis	KLLA0F01122g	XP_455130.1

Gene Ontology
Bibliography

Related articles in PubMed

Insights into RNA biology from an atlas of mammalian mRNA-binding proteins.
Castello A, Fischer B, Eichelbaum K, Horos R, Beckmann BM, Strein C, Davey NE, Humphreys DT, Preiss T, Steinmetz LM, Krijgsveld J, Hentze MW
Cell149(6)1393-406(2012 Jun)

The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.
Baltz AG, Munschauer M, Schwanh?usser B, Vasile A, Murakawa Y, Schueler M, Youngs N, Penfold-Brown D, Drew K, Milek M, Wyler E, Bonneau R, Selbach M, Dieterich C, Landthaler M
Molecular cell46(5)674-90(2012 Jun)

Transcriptional repressor NIR functions in the ribosome RNA processing of both 40S and 60S subunits.
Wu J, Zhang Y, Wang Y, Kong R, Hu L, Schuele R, Du X, Ke Y
PloS one7(2)e31692(2012)

Comparison of an expanded ataxia interactome with patient medical records reveals a relationship between macular degeneration and ataxia.
Kahle JJ, Gulbahce N, Shaw CA, Lim J, Hill DE, Barab?si AL, Zoghbi HY
Human molecular genetics20(3)510-27(2011 Feb)

Aurora B interacts with NIR-p53, leading to p53 phosphorylation in its DNA-binding domain and subsequent functional suppression.
Wu L, Ma CA, Zhao Y, Jain A
The Journal of biological chemistry286(3)2236-44(2011 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

A transcriptional repressor NIR functions in the rRNA biogenesis of both the 40S and 60S subunits.
Title: Transcriptional repressor NIR functions in the ribosome RNA processing of both 40S and 60S subunits.

Aurora B interacts with NIR-p53, leading to p53 phosphorylation in its DNA-binding domain and subsequent functional suppression.
Title: Aurora B interacts with NIR-p53, leading to p53 phosphorylation in its DNA-binding domain and subsequent functional suppression.

Upon recruitment by p53, NIR represses transcription of both p53-dependent reporters and endogenous target genes
Title: NIR is a novel INHAT repressor that modulates the transcriptional activity of p53.

The following NOC2L gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the NOC2L cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu28002	NM_015658.3 Latest version!	Homo sapiens NOC2 like nucleolar associated transcriptional repressor (NOC2L), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu107370	NM_015658.4 Latest version!	Homo sapiens NOC2 like nucleolar associated transcriptional repressor (NOC2L), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$391.30 $559.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

NOC2L ( NM_015658.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_056473.2 Homo sapiens NOC2 like nucleolar associated transcriptional repressor (NOC2L), mRNA.

Price & Availability↑

CloneID	OHu28002
Clone ID Related Accession (Same CDS sequence)	NM_015658.3
Accession Version	NM_015658.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2250bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	nucleolar complex protein 2 homolog
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DA002961.1, BC003555.1, AW749585.1, AK225239.1 and BX645732.1. On Sep 27, 2007 this sequence version replaced NM_015658.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK225239.1, SRR1803616.91424.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCAGCTG CGGGGAGCCG CAAGAGGCGC CTGGCGGAGC TGACGGTGGA CGAGTTCCTA 
GCTTCGGGCT TTGACTCCGA GTCCGAATCC GAGTCCGAAA ATTCTCCACA AGCGGAGACA 
CGGGAAGCAC GCGAGGCTGC CCGGAGTCCG GATAAGCCGG GCGGGAGCCC CTCGGCCAGC 
CGGCGTAAAG GCCGTGCCTC TGAGCACAAA GACCAGCTCT CTCGGCTGAA GGACAGAGAC 
CCCGAGTTCT ACAAGTTCCT GCAGGAGAAT GACCAGAGCC TGCTAAACTT CAGCGACTCG 
GACAGCTCTG AGGAGGAAGA GGGGCCGTTC CACTCCCTGC CAGATGTGCT GGAGGAAGCC 
AGTGAGGAGG AGGATGGAGC GGAGGAAGGA GAAGATGGGG ACAGAGTCCC CAGAGGGCTG 
AAGGGGAAGA AGAATTCTGT TCCTGTGACC GTCGCCATGG TTGAGAGATG GAAGCAGGCA 
GCAAAGCAAC GCCTCACTCC AAAGCTGTTC CATGAAGTGG TACAGGCGTT CCGAGCAGCT 
GTGGCCACCA CCCGAGGGGA CCAGGAAAGT GCTGAGGCCA ACAAATTCCA GGTCACGGAC 
AGTGCTGCAT TCAATGCTCT GGTTACCTTC TGCATCAGAG ACCTCATTGG CTGTCTCCAG 
AAGCTGCTGT TTGGAAAGGT GGCAAAGGAT AGCAGCAGGA TGCTGCAGCC GTCCAGCAGC 
CCGCTCTGGG GGAAGCTTCG TGTGGACATC AAGGCTTACC TGGGCTCGGC CATACAGCTG 
GTGTCCTGTC TGTCGGAGAC GACGGTGTTG GCGGCCGTGC TGCGGCACAT CAGCGTGCTG 
GTGCCCTGCT TCCTGACCTT CCCCAAGCAG TGCCGCATGC TGCTCAAGAG AATGGTGGTC 
GTATGGAGCA CTGGGGAAGA GTCTCTGCGG GTGCTGGCTT TCCTGGTCCT CAGCAGAGTC 
TGCCGGCACA AGAAGGACAC TTTCCTTGGC CCCGTCCTCA AGCAAATGTA CATCACGTAT 
GTGAGGAACT GCAAGTTCAC CTCGCCTGGT GCCCTCCCCT TCATCAGTTT CATGCAGTGG 
ACCTTGACGG AGCTGCTGGC CCTGGAGCCG GGTGTGGCCT ACCAGCACGC CTTCCTCTAC 
ATCCGCCAGC TCGCCATACA CCTGCGCAAC GCCATGACCA CCCGCAAGAA GGAAACATAC 
CAGTCTGTGT ACAACTGGCA GTATGTGCAC TGCCTCTTCC TGTGGTGCCG GGTCCTGAGC 
ACTGCGGGCC CCAGCGAAGC CCTCCAGCCC TTGGTCTACC CCCTTGCCCA AGTCATCATT 
GGCTGTATCA AGCTCATCCC CACTGCCCGC TTCTACCCGC TGCGAATGCA CTGCATCCGT 
GCCCTGACGC TGCTCTCGGG GAGCTCGGGG GCCTTCATCC CGGTGCTGCC TTTCATCCTG 
GAGATGTTCC AGCAGGTCGA CTTCAACAGG AAGCCAGGGC GCATGAGCTC CAAGCCCATC 
AACTTCTCCG TGATCCTGAA GCTGTCCAAT GTCAACCTGC AGGAGAAGGC GTACCGGGAC 
GGCCTGGTGG AGCAGCTGTA CGACCTCACC CTGGAGTACC TGCACAGCCA GGCACACTGC 
ATCGGCTTCC CGGAGCTGGT GCTGCCTGTG GTCCTGCAGC TGAAGTCGTT CCTCCGGGAG 
TGCAAGGTGG CCAACTACTG CCGGCAGGTG CAGCAGCTGC TTGGGAAGGT TCAGGAGAAC 
TCGGCATACA TCTGCAGCCG CCGCCAGAGG GTTTCCTTCG GCGTCTCTGA GCAGCAGGCA 
GTGGAAGCCT GGGAGAAGCT GACCCGGGAA GAGGGGACAC CCCTGACCTT GTACTACAGC 
CACTGGCGCA AGCTGCGTGA CCGGGAGATC CAGCTGGAGA TCAGTGGCAA AGAGCGGCTG 
GAAGACCTGA ACTTCCCTGA GATCAAACGA AGGAAGATGG CTGACAGGAA GGATGAGGAC 
AGGAAGCAAT TTAAAGACCT CTTTGACCTG AACAGCTCTG AAGAGGACGA CACCGAGGGA 
TTCTCGGAGA GAGGGATACT GAGGCCCCTG AGCACTCGGC ATGGGGTGGA AGACGATGAA 
GAGGACGAGG AGGAGGGCGA GGAGGACAGC AGCAACTCGG AGGATGGAGA CCCAGACGCA 
GAGGCGGGGC TGGCCCCTGG GGAGCTGCAG CAGCTGGCCC AGGGGCCGGA GGACGAGCTG 
GAGGATCTGC AGCTCTCAGA GGACGACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_056473.2
CDS	60..2309
Translation	MAAAGSRKRRLAELTVDEFLASGFDSESESESENSPQAETREAREAARSPDKPGGSPSASRRKGRASEHKDQLSRLKDRDPEFYKFLQENDQSLLNFSDSDSSEEEEGPFHSLPDVLEEASEEEDGAEEGEDGDRVPRGLKGKKNSVPVTVAMVERWKQAAKQRLTPKLFHEVVQAFRAAVATTRGDQESAEANKFQVTDSAAFNALVTFCIRDLIGCLQKLLFGKVAKDSSRMLQPSSSPLWGKLRVDIKAYLGSAIQLVSCLSETTVLAAVLRHISVLVPCFLTFPKQCRMLLKRMVVVWSTGEESLRVLAFLVLSRVCRHKKDTFLGPVLKQMYITYVRNCKFTSPGALPFISFMQWTLTELLALEPGVAYQHAFLYIRQLAIHLRNAMTTRKKETYQSVYNWQYVHCLFLWCRVLSTAGPSEALQPLVYPLAQVIIGCIKLIPTARFYPLRMHCIRALTLLSGSSGAFIPVLPFILEMFQQVDFNRKPGRMSSKPINFSVILKLSNVNLQEKAYRDGLVEQLYDLTLEYLHSQAHCIGFPELVLPVVLQLKSFLRECKVANYCRQVQQLLGKVQENSAYICSRRQRVSFGVSEQQAVEAWEKLTREEGTPLTLYYSHWRKLRDREIQLEISGKERLEDLNFPEIKRRKMADRKDEDRKQFKDLFDLNSSEEDDTEGFSERGILRPLSTRHGVEDDEEDEEEGEEDSSNSEDGDPDAEAGLAPGELQQLAQGPEDELEDLQLSEDD

Target ORF information:

RefSeq Version	NM_015658.3
Organism	Homo sapiens(human)
Definition	Homo sapiens NOC2 like nucleolar associated transcriptional repressor (NOC2L), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_015658.3

ORF Insert Sequence:

ATGGCAGCTG CGGGGAGCCG CAAGAGGCGC CTGGCGGAGC TGACGGTGGA CGAGTTCCTA 
GCTTCGGGCT TTGACTCCGA GTCCGAATCC GAGTCCGAAA ATTCTCCACA AGCGGAGACA 
CGGGAAGCAC GCGAGGCTGC CCGGAGTCCG GATAAGCCGG GCGGGAGCCC CTCGGCCAGC 
CGGCGTAAAG GCCGTGCCTC TGAGCACAAA GACCAGCTCT CTCGGCTGAA GGACAGAGAC 
CCCGAGTTCT ACAAGTTCCT GCAGGAGAAT GACCAGAGCC TGCTAAACTT CAGCGACTCG 
GACAGCTCTG AGGAGGAAGA GGGGCCGTTC CACTCCCTGC CAGATGTGCT GGAGGAAGCC 
AGTGAGGAGG AGGATGGAGC GGAGGAAGGA GAAGATGGGG ACAGAGTCCC CAGAGGGCTG 
AAGGGGAAGA AGAATTCTGT TCCTGTGACC GTCGCCATGG TTGAGAGATG GAAGCAGGCA 
GCAAAGCAAC GCCTCACTCC AAAGCTGTTC CATGAAGTGG TACAGGCGTT CCGAGCAGCT 
GTGGCCACCA CCCGAGGGGA CCAGGAAAGT GCTGAGGCCA ACAAATTCCA GGTCACGGAC 
AGTGCTGCAT TCAATGCTCT GGTTACCTTC TGCATCAGAG ACCTCATTGG CTGTCTCCAG 
AAGCTGCTGT TTGGAAAGGT GGCAAAGGAT AGCAGCAGGA TGCTGCAGCC GTCCAGCAGC 
CCGCTCTGGG GGAAGCTTCG TGTGGACATC AAGGCTTACC TGGGCTCGGC CATACAGCTG 
GTGTCCTGTC TGTCGGAGAC GACGGTGTTG GCGGCCGTGC TGCGGCACAT CAGCGTGCTG 
GTGCCCTGCT TCCTGACCTT CCCCAAGCAG TGCCGCATGC TGCTCAAGAG AATGGTGGTC 
GTATGGAGCA CTGGGGAAGA GTCTCTGCGG GTGCTGGCTT TCCTGGTCCT CAGCAGAGTC 
TGCCGGCACA AGAAGGACAC TTTCCTTGGC CCCGTCCTCA AGCAAATGTA CATCACGTAT 
GTGAGGAACT GCAAGTTCAC CTCGCCTGGT GCCCTCCCCT TCATCAGTTT CATGCAGTGG 
ACCTTGACGG AGCTGCTGGC CCTGGAGCCG GGTGTGGCCT ACCAGCACGC CTTCCTCTAC 
ATCCGCCAGC TCGCCATACA CCTGCGCAAC GCCATGACCA CCCGCAAGAA GGAAACATAC 
CAGTCTGTGT ACAACTGGCA GTATGTGCAC TGCCTCTTCC TGTGGTGCCG GGTCCTGAGC 
ACTGCGGGCC CCAGCGAAGC CCTCCAGCCC TTGGTCTACC CCCTTGCCCA AGTCATCATT 
GGCTGTATCA AGCTCATCCC CACTGCCCGC TTCTACCCGC TGCGAATGCA CTGCATCCGT 
GCCCTGACGC TGCTCTCGGG GAGCTCGGGG GCCTTCATCC CGGTGCTGCC TTTCATCCTG 
GAGATGTTCC AGCAGGTCGA CTTCAACAGG AAGCCAGGGC GCATGAGCTC CAAGCCCATC 
AACTTCTCCG TGATCCTGAA GCTGTCCAAT GTCAACCTGC AGGAGAAGGC GTACCGGGAC 
GGCCTGGTGG AGCAGCTGTA CGACCTCACC CTGGAGTACC TGCACAGCCA GGCACACTGC 
ATCGGCTTCC CGGAGCTGGT GCTGCCTGTG GTCCTGCAGC TGAAGTCGTT CCTCCGGGAG 
TGCAAGGTGG CCAACTACTG CCGGCAGGTG CAGCAGCTGC TTGGGAAGGT TCAGGAGAAC 
TCGGCATACA TCTGCAGCCG CCGCCAGAGG GTTTCCTTCG GCGTCTCTGA GCAGCAGGCA 
GTGGAAGCCT GGGAGAAGCT GACCCGGGAA GAGGGGACAC CCCTGACCTT GTACTACAGC 
CACTGGCGCA AGCTGCGTGA CCGGGAGATC CAGCTGGAGA TCAGTGGCAA AGAGCGGCTG 
GAAGACCTGA ACTTCCCTGA GATCAAACGA AGGAAGATGG CTGACAGGAA GGATGAGGAC 
AGGAAGCAAT TTAAAGACCT CTTTGACCTG AACAGCTCTG AAGAGGACGA CACCGAGGGA 
TTCTCGGAGA GAGGGATACT GAGGCCCCTG AGCACTCGGC ATGGGGTGGA AGACGATGAA 
GAGGACGAGG AGGAGGGCGA GGAGGACAGC AGCAACTCGG AGGATGGAGA CCCAGACGCA 
GAGGCGGGGC TGGCCCCTGG GGAGCTGCAG CAGCTGGCCC AGGGGCCGGA GGACGAGCTG 
GAGGATCTGC AGCTCTCAGA GGACGACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

NOC2L ( NM_015658.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_056473.3 Homo sapiens NOC2 like nucleolar associated transcriptional repressor (NOC2L), mRNA.

Price & Availability↑

CloneID	OHu107370
Clone ID Related Accession (Same CDS sequence)	NM_015658.4
Accession Version	NM_015658.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2250bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Homo sapiens(human)
Product	nucleolar complex protein 2 homolog
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AL645608.30. On Nov 23, 2018 this sequence version replaced NM_015658.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK225239.1, AK024284.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000327044.7/ ENSP00000317992.6 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCAGCTG CGGGGAGCCG CAAGAGGCGC CTGGCGGAGC TGACGGTGGA CGAGTTCCTA 
GCTTCGGGCT TTGACTCCGA GTCCGAATCC GAGTCCGAAA ATTCTCCACA AGCGGAGACA 
CGGGAAGCAC GCGAGGCTGC CCGGAGTCCG GATAAGCCGG GCGGGAGCCC CTCGGCCAGC 
CGGCGTAAAG GCCGTGCCTC TGAGCACAAA GACCAGCTCT CTCGGCTGAA GGACAGAGAC 
CCCGAGTTCT ACAAGTTCCT GCAGGAGAAT GACCAGAGCC TGCTAAACTT CAGCGACTCG 
GACAGCTCTG AGGAGGAAGA GGGGCCGTTC CACTCCCTGC CAGATGTGCT GGAGGAAGCC 
AGTGAGGAGG AGGATGGAGC GGAGGAAGGA GAAGATGGGG ACAGAGTCCC CAGAGGGCTG 
AAGGGGAAGA AGAATTCTGT TCCTGTGACC GTCGCCATGG TTGAGAGATG GAAGCAGGCA 
GCAAAGCAAC GCCTCACTCC AAAGCTGTTC CATGAAGTGG TACAGGCGTT CCGAGCAGCT 
GTGGCCACCA CCCGAGGGGA CCAGGAAAGT GCTGAGGCCA ACAAATTCCA GGTCACGGAC 
AGTGCTGCAT TCAATGCTCT GGTTACCTTC TGCATCAGAG ACCTCATTGG CTGTCTCCAG 
AAGCTGCTGT TTGGAAAGGT GGCAAAGGAT AGCAGCAGGA TGCTGCAGCC GTCCAGCAGC 
CCGCTCTGGG GGAAGCTTCG TGTGGACATC AAGGCTTACC TGGGCTCGGC CATACAGCTG 
GTGTCCTGTC TGTCGGAGAC GACGGTGTTG GCGGCCGTGC TGCGGCACAT CAGCGTGCTG 
GTGCCCTGCT TCCTGACCTT CCCCAAGCAG TGCCGCATGC TGCTCAAGAG AATGGTGATC 
GTATGGAGCA CTGGGGAAGA GTCTCTGCGG GTGCTGGCTT TCCTGGTCCT CAGCAGAGTC 
TGCCGGCACA AGAAGGACAC TTTCCTTGGC CCCGTCCTCA AGCAAATGTA CATCACGTAT 
GTGAGGAACT GCAAGTTCAC CTCGCCTGGT GCCCTCCCCT TCATCAGTTT CATGCAGTGG 
ACCTTGACGG AGCTGCTGGC CCTGGAGCCG GGTGTGGCCT ACCAGCACGC CTTCCTCTAC 
ATCCGCCAGC TCGCCATACA CCTGCGCAAC GCCATGACCA CTCGCAAGAA GGAAACATAC 
CAGTCTGTGT ACAACTGGCA GTATGTGCAC TGCCTCTTCC TGTGGTGCCG GGTCCTGAGC 
ACTGCGGGCC CCAGCGAAGC CCTCCAGCCC TTGGTCTACC CCCTTGCCCA AGTCATCATT 
GGCTGTATCA AGCTCATCCC CACTGCCCGC TTCTACCCGC TGCGAATGCA CTGCATCCGT 
GCCCTGACGC TGCTCTCGGG GAGCTCGGGG GCCTTCATCC CGGTGCTGCC TTTCATCCTG 
GAGATGTTCC AGCAGGTCGA CTTCAACAGG AAGCCAGGGC GCATGAGCTC CAAGCCCATC 
AACTTCTCCG TGATCCTGAA GCTGTCCAAT GTCAACCTGC AGGAGAAGGC GTACCGGGAC 
GGCCTGGTGG AGCAGCTGTA CGACCTCACC CTGGAGTACC TGCACAGCCA GGCACACTGC 
ATCGGCTTCC CGGAGCTGGT GCTGCCTGTG GTCCTGCAGC TGAAGTCGTT CCTCCGGGAG 
TGCAAGGTGG CCAACTACTG CCGGCAGGTG CAGCAGCTGC TTGGGAAGGT TCAGGAGAAC 
TCGGCATACA TCTGCAGCCG CCGCCAGAGG GTTTCCTTCG GCGTCTCTGA GCAGCAGGCA 
GTGGAAGCCT GGGAGAAGCT GACCCGGGAA GAGGGGACAC CCCTGACCTT GTACTACAGC 
CACTGGCGCA AGCTGCGTGA CCGGGAGATC CAGCTGGAGA TCAGTGGCAA AGAGCGGCTG 
GAAGACCTGA ACTTCCCTGA GATCAAACGA AGGAAGATGG CTGACAGGAA GGATGAGGAC 
AGGAAGCAAT TTAAAGACCT CTTTGACCTG AACAGCTCTG AAGAGGACGA CACCGAGGGA 
TTCTCGGAGA GAGGGATACT GAGGCCCCTG AGCACTCGGC ATGGGGTGGA AGACGATGAA 
GAGGACGAGG AGGAGGGCGA GGAGGACAGC AGCAACTCGG AGGATGGAGA CCCAGACGCA 
GAGGCGGGGC TGGCCCCTGG GGAGCTGCAG CAGCTGGCCC AGGGGCCGGA GGACGAGCTG 
GAGGATCTGC AGCTCTCAGA GGACGACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_056473.3
CDS	17..2266
Translation	MAAAGSRKRRLAELTVDEFLASGFDSESESESENSPQAETREAREAARSPDKPGGSPSASRRKGRASEHKDQLSRLKDRDPEFYKFLQENDQSLLNFSDSDSSEEEEGPFHSLPDVLEEASEEEDGAEEGEDGDRVPRGLKGKKNSVPVTVAMVERWKQAAKQRLTPKLFHEVVQAFRAAVATTRGDQESAEANKFQVTDSAAFNALVTFCIRDLIGCLQKLLFGKVAKDSSRMLQPSSSPLWGKLRVDIKAYLGSAIQLVSCLSETTVLAAVLRHISVLVPCFLTFPKQCRMLLKRMVIVWSTGEESLRVLAFLVLSRVCRHKKDTFLGPVLKQMYITYVRNCKFTSPGALPFISFMQWTLTELLALEPGVAYQHAFLYIRQLAIHLRNAMTTRKKETYQSVYNWQYVHCLFLWCRVLSTAGPSEALQPLVYPLAQVIIGCIKLIPTARFYPLRMHCIRALTLLSGSSGAFIPVLPFILEMFQQVDFNRKPGRMSSKPINFSVILKLSNVNLQEKAYRDGLVEQLYDLTLEYLHSQAHCIGFPELVLPVVLQLKSFLRECKVANYCRQVQQLLGKVQENSAYICSRRQRVSFGVSEQQAVEAWEKLTREEGTPLTLYYSHWRKLRDREIQLEISGKERLEDLNFPEIKRRKMADRKDEDRKQFKDLFDLNSSEEDDTEGFSERGILRPLSTRHGVEDDEEDEEEGEEDSSNSEDGDPDAEAGLAPGELQQLAQGPEDELEDLQLSEDD

Target ORF information:

RefSeq Version	NM_015658.4
Organism	Homo sapiens(human)
Definition	Homo sapiens NOC2 like nucleolar associated transcriptional repressor (NOC2L), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_015658.4

ORF Insert Sequence:

ATGGCAGCTG CGGGGAGCCG CAAGAGGCGC CTGGCGGAGC TGACGGTGGA CGAGTTCCTA 
GCTTCGGGCT TTGACTCCGA GTCCGAATCC GAGTCCGAAA ATTCTCCACA AGCGGAGACA 
CGGGAAGCAC GCGAGGCTGC CCGGAGTCCG GATAAGCCGG GCGGGAGCCC CTCGGCCAGC 
CGGCGTAAAG GCCGTGCCTC TGAGCACAAA GACCAGCTCT CTCGGCTGAA GGACAGAGAC 
CCCGAGTTCT ACAAGTTCCT GCAGGAGAAT GACCAGAGCC TGCTAAACTT CAGCGACTCG 
GACAGCTCTG AGGAGGAAGA GGGGCCGTTC CACTCCCTGC CAGATGTGCT GGAGGAAGCC 
AGTGAGGAGG AGGATGGAGC GGAGGAAGGA GAAGATGGGG ACAGAGTCCC CAGAGGGCTG 
AAGGGGAAGA AGAATTCTGT TCCTGTGACC GTCGCCATGG TTGAGAGATG GAAGCAGGCA 
GCAAAGCAAC GCCTCACTCC AAAGCTGTTC CATGAAGTGG TACAGGCGTT CCGAGCAGCT 
GTGGCCACCA CCCGAGGGGA CCAGGAAAGT GCTGAGGCCA ACAAATTCCA GGTCACGGAC 
AGTGCTGCAT TCAATGCTCT GGTTACCTTC TGCATCAGAG ACCTCATTGG CTGTCTCCAG 
AAGCTGCTGT TTGGAAAGGT GGCAAAGGAT AGCAGCAGGA TGCTGCAGCC GTCCAGCAGC 
CCGCTCTGGG GGAAGCTTCG TGTGGACATC AAGGCTTACC TGGGCTCGGC CATACAGCTG 
GTGTCCTGTC TGTCGGAGAC GACGGTGTTG GCGGCCGTGC TGCGGCACAT CAGCGTGCTG 
GTGCCCTGCT TCCTGACCTT CCCCAAGCAG TGCCGCATGC TGCTCAAGAG AATGGTGATC 
GTATGGAGCA CTGGGGAAGA GTCTCTGCGG GTGCTGGCTT TCCTGGTCCT CAGCAGAGTC 
TGCCGGCACA AGAAGGACAC TTTCCTTGGC CCCGTCCTCA AGCAAATGTA CATCACGTAT 
GTGAGGAACT GCAAGTTCAC CTCGCCTGGT GCCCTCCCCT TCATCAGTTT CATGCAGTGG 
ACCTTGACGG AGCTGCTGGC CCTGGAGCCG GGTGTGGCCT ACCAGCACGC CTTCCTCTAC 
ATCCGCCAGC TCGCCATACA CCTGCGCAAC GCCATGACCA CTCGCAAGAA GGAAACATAC 
CAGTCTGTGT ACAACTGGCA GTATGTGCAC TGCCTCTTCC TGTGGTGCCG GGTCCTGAGC 
ACTGCGGGCC CCAGCGAAGC CCTCCAGCCC TTGGTCTACC CCCTTGCCCA AGTCATCATT 
GGCTGTATCA AGCTCATCCC CACTGCCCGC TTCTACCCGC TGCGAATGCA CTGCATCCGT 
GCCCTGACGC TGCTCTCGGG GAGCTCGGGG GCCTTCATCC CGGTGCTGCC TTTCATCCTG 
GAGATGTTCC AGCAGGTCGA CTTCAACAGG AAGCCAGGGC GCATGAGCTC CAAGCCCATC 
AACTTCTCCG TGATCCTGAA GCTGTCCAAT GTCAACCTGC AGGAGAAGGC GTACCGGGAC 
GGCCTGGTGG AGCAGCTGTA CGACCTCACC CTGGAGTACC TGCACAGCCA GGCACACTGC 
ATCGGCTTCC CGGAGCTGGT GCTGCCTGTG GTCCTGCAGC TGAAGTCGTT CCTCCGGGAG 
TGCAAGGTGG CCAACTACTG CCGGCAGGTG CAGCAGCTGC TTGGGAAGGT TCAGGAGAAC 
TCGGCATACA TCTGCAGCCG CCGCCAGAGG GTTTCCTTCG GCGTCTCTGA GCAGCAGGCA 
GTGGAAGCCT GGGAGAAGCT GACCCGGGAA GAGGGGACAC CCCTGACCTT GTACTACAGC 
CACTGGCGCA AGCTGCGTGA CCGGGAGATC CAGCTGGAGA TCAGTGGCAA AGAGCGGCTG 
GAAGACCTGA ACTTCCCTGA GATCAAACGA AGGAAGATGG CTGACAGGAA GGATGAGGAC 
AGGAAGCAAT TTAAAGACCT CTTTGACCTG AACAGCTCTG AAGAGGACGA CACCGAGGGA 
TTCTCGGAGA GAGGGATACT GAGGCCCCTG AGCACTCGGC ATGGGGTGGA AGACGATGAA 
GAGGACGAGG AGGAGGGCGA GGAGGACAGC AGCAACTCGG AGGATGGAGA CCCAGACGCA 
GAGGCGGGGC TGGCCCCTGG GGAGCTGCAG CAGCTGGCCC AGGGGCCGGA GGACGAGCTG 
GAGGATCTGC AGCTCTCAGA GGACGACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Insights into RNA biology from an atlas of mammalian mRNA-binding proteins.
Cell149(6)1393-406(2012 Jun)
Castello A,Fischer B,Eichelbaum K,Horos R,Beckmann BM,Strein C,Davey NE,Humphreys DT,Preiss T,Steinmetz LM,Krijgsveld J,Hentze MW

The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.
Molecular cell46(5)674-90(2012 Jun)
Baltz AG,Munschauer M,Schwanh?usser B,Vasile A,Murakawa Y,Schueler M,Youngs N,Penfold-Brown D,Drew K,Milek M,Wyler E,Bonneau R,Selbach M,Dieterich C,Landthaler M

Transcriptional repressor NIR functions in the ribosome RNA processing of both 40S and 60S subunits.
PloS one7(2)e31692(2012)
Wu J,Zhang Y,Wang Y,Kong R,Hu L,Schuele R,Du X,Ke Y

Comparison of an expanded ataxia interactome with patient medical records reveals a relationship between macular degeneration and ataxia.
Human molecular genetics20(3)510-27(2011 Feb)
Kahle JJ,Gulbahce N,Shaw CA,Lim J,Hill DE,Barab?si AL,Zoghbi HY

Aurora B interacts with NIR-p53, leading to p53 phosphorylation in its DNA-binding domain and subsequent functional suppression.
The Journal of biological chemistry286(3)2236-44(2011 Jan)
Wu L,Ma CA,Zhao Y,Jain A