NOL11 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	NOL11
Entrez Gene ID	25926
Full Name	nucleolar protein 11
General protein information	Preferred Names nucleolar protein 11 Names nucleolar protein 11
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 17 Map Location: 17q24.2
Disorder MIM:	615366

mRNA and Protein(s)

mRNA	Protein	Name
NM_015462.4	NP_056277.2	nucleolar protein 11 isoform 1
NM_015462.5	NP_056277.2	nucleolar protein 11 isoform 1
NM_001303272.1	NP_001290201.1	nucleolar protein 11 isoform 2

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	NOL11	XP_001164856.1
Mus musculus (house mouse)	Nol11	NP_001154801.1
Bos taurus (cattle)	NOL11	NP_001029697.1
Gallus gallus (chicken)	NOL11	NP_001006210.1
Homo sapiens (human)	NOL11	NP_056277.2
	NOL11	XP_001116852.2
Rattus norvegicus (Norway rat)	Nol11	XP_006247721.1
Gallus gallus (chicken)	LOC100859426	XP_003642386.1
Canis lupus familiaris (dog)	NOL11	XP_853495.1
Danio rerio (zebrafish)	nol11	NP_001025234.1

Gene Ontology
Bibliography

Related articles in PubMed

Architecture of the human interactome defines protein communities and disease networks.
Huttlin EL, Bruckner RJ, Paulo JA, Cannon JR, Ting L, Baltier K, Colby G, Gebreab F, Gygi MP, Parzen H, Szpyt J, Tam S, Zarraga G, Pontano-Vaites L, Swarup S, White AE, Schweppe DK, Rad R, Erickson BK, Obar RA, Guruharsha KG, Li K, Artavanis-Tsakonas S, Gygi SP, Harper JW
Nature545(7655)505-509(2017 05)

GABRA1 and STXBP1: novel genetic causes of Dravet syndrome.
Carvill GL, Weckhuysen S, McMahon JM, Hartmann C, M?ller RS, Hjalgrim H, Cook J, Geraghty E, O'Roak BJ, Petrou S, Clarke A, Gill D, Sadleir LG, Muhle H, von Spiczak S, Nikanorova M, Hodgson BL, Gazina EV, Suls A, Shendure J, Dibbens LM, De Jonghe P, Helbig I, Berkovic SF, Scheffer IE, Mefford HC
Neurology82(14)1245-53(2014 Apr)

Insights into RNA biology from an atlas of mammalian mRNA-binding proteins.
Castello A, Fischer B, Eichelbaum K, Horos R, Beckmann BM, Strein C, Davey NE, Humphreys DT, Preiss T, Steinmetz LM, Krijgsveld J, Hentze MW
Cell149(6)1393-406(2012 Jun)

The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.
Baltz AG, Munschauer M, Schwanh?usser B, Vasile A, Murakawa Y, Schueler M, Youngs N, Penfold-Brown D, Drew K, Milek M, Wyler E, Bonneau R, Selbach M, Dieterich C, Landthaler M
Molecular cell46(5)674-90(2012 Jun)

NOL11, implicated in the pathogenesis of North American Indian childhood cirrhosis, is required for pre-rRNA transcription and processing.
Freed EF, Prieto JL, McCann KL, McStay B, Baserga SJ
PLoS genetics8(8)e1002892(2012)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

NOL11 is a novel protein required for the early stages of ribosome biogenesis in humans and is implicated in the pathogenesis of North American Indian childhood cirrhosis.
Title: NOL11, implicated in the pathogenesis of North American Indian childhood cirrhosis, is required for pre-rRNA transcription and processing.

The following NOL11 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the NOL11 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu66640	NM_001303272.1 Latest version!	Homo sapiens nucleolar protein 11 (NOL11), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00
OHu66639	NM_015462.5 Latest version!	Homo sapiens nucleolar protein 11 (NOL11), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$510.30 $729.00
View Old Accession Versions >>
OHu66639	NM_015462.4	Homo sapiens nucleolar protein 11 (NOL11), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$510.30 $729.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

NOL11 ( NM_001303272.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001290201.1 Homo sapiens nucleolar protein 11 (NOL11), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu66640
Clone ID Related Accession (Same CDS sequence)	NM_001303272.1
Accession Version	NM_001303272.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1614bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-10
Organism	Homo sapiens(human)
Product	nucleolar protein 11 isoform 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DA772356.1, AK299483.1, AC006534.10 and AW273123.1. Transcript Variant: This variant (2) lacks an alternate exon in the 5' region and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus than isoform 1. ##Evidence-Data-START## Transcript exon combination :: AK299483.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2142586, SAMEA2149004 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTTTAACT CACGTATCTT AACCAAATAT ACACTCTTAC TTGGACAAGA CGAAAACTCT 
GTTATAAAGA GTTTTACTGC ATCTGTAGAT CGGAAATTCA TCTCTTTGAT GTCATTAAGC 
TCTGATGGTT GTATATATGA AACCTTGATA CCAATACGTC CAGCTGACCC AGAAAAAAAT 
CAGAGCTTAG TTAAATCACT GCTGCTCAAG GCTGTTGTAT CTGGTAACGC TCGAAATGGA 
GTTGCACTCA CTGCCCTGGA TCAGGATCAC GTCGCAGTCC TAGGAAGTCC ACTAGCAGCT 
TCTAAGGAAT GCCTCTCTGT ATGGAACATA AAATTTCAAA CACTACAGAC TTCAAAAGAG 
TTACCACAAG GGACCAGTGG TCAACTCTGG TATTATGGAG AACATTTGTT TATGCTACAT 
GGAAAATCTC TAACTGTGAT TCCATACAAG TGTGAAGTGT CATCATTAGC AGGTGCTCTT 
GGAAAACTCA AGCATAGTCA AGATCCAGGA ACTCATGTCG TGTCCCATTT TGTAAACTGG 
GAGACACCTC AAGGATGTGG ACTTGGGTTC CAGAACTCAG AGCAGTCAAG AAGAATTTTA 
AGGAGACGAA AAATTGAAGT GAGTTTACAG CCAGAGGTTC CACCATCCAA ACAACTTTTG 
TCAACCATAA TGAAAGATTC AGAAAAACAC ATTGAAGTAG AAGTACGGAA ATTTTTGGCT 
CTGAAGCAGA CACCTGACTT TCATACTGTC ATTGGGGACA CAGTAACAGG ACTTCTGGAA 
AGGTGTAAAG CAGAACCATC ATTTTATCCC CGGAACTGTC TGATGCAGCT TATCCAAACG 
CATGTGCTTT CTTACAGTTT GTGCCCCGAC TTAATGGAGA TTGCCTTAAA AAAGAAAGAT 
GTACAGTTGT TACAACTCTG TCTACAGCAG TTCCCTGACA TTCCTGAATC AGTCACCTGT 
GCTTGCTTAA AAATTTTCTT GAGCATTGGT GATGACAGTC TTCAAGAAAC AGATGTTAAT 
ATGGAGTCAG TTTTTGACTA TAGTATAAAT TCTGTACATG ATGAGAAAAT GGAAGAGCAA 
ACTGAAATTC TTCAAAATGG CTTCAATCCT GAAGAAGATA AATGCAATAA CTGTGATCAA 
GAGTTAAATA AAAAGCCCCA GGACGAAACA AAGGAGAGCA CTTCATGCCC TGTGGTACAA 
AAAAGAGCAG CTCTACTTAA TGCAATTCTT CATTCAGCAT ATAGCGAGAC ATTTCTTCTG 
CCTCATTTGA AAGACATCCC AGCACAGCAT ATCACGCTGT TTCTTAAGTA TTTGTATTTC 
CTGTACCTGA AGTGTAGCGA AAATGCTACT ATGACTCTTC CTGGAATACA CCCACCTACC 
TTGAACCAGA TTATGGATTG GATATGTCTA CTTCTGGATG CAAATTTTAC TGTTGTTGTA 
ATGATGCCAG AAGCAAAGAG GCTACTGATA AATCTTTACA AGCTTGTAAA ATCTCAGATA 
TCTGTTTATT CTGAGCTCAA CAAGATTGAA GTAAGTTTTC GGGAGCTACA GAAATTAAAT 
CAAGAAAAGA ATAATAGAGG ATTATATTCA ATTGAAGTGC TGGAGCTCTT CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001290201.1
CDS	604..2217
Translation	MFNSRILTKYTLLLGQDENSVIKSFTASVDRKFISLMSLSSDGCIYETLIPIRPADPEKNQSLVKSLLLKAVVSGNARNGVALTALDQDHVAVLGSPLAASKECLSVWNIKFQTLQTSKELPQGTSGQLWYYGEHLFMLHGKSLTVIPYKCEVSSLAGALGKLKHSQDPGTHVVSHFVNWETPQGCGLGFQNSEQSRRILRRRKIEVSLQPEVPPSKQLLSTIMKDSEKHIEVEVRKFLALKQTPDFHTVIGDTVTGLLERCKAEPSFYPRNCLMQLIQTHVLSYSLCPDLMEIALKKKDVQLLQLCLQQFPDIPESVTCACLKIFLSIGDDSLQETDVNMESVFDYSINSVHDEKMEEQTEILQNGFNPEEDKCNNCDQELNKKPQDETKESTSCPVVQKRAALLNAILHSAYSETFLLPHLKDIPAQHITLFLKYLYFLYLKCSENATMTLPGIHPPTLNQIMDWICLLLDANFTVVVMMPEAKRLLINLYKLVKSQISVYSELNKIEVSFRELQKLNQEKNNRGLYSIEVLELF

Target ORF information:

RefSeq Version	NM_001303272.1
Organism	Homo sapiens(human)
Definition	Homo sapiens nucleolar protein 11 (NOL11), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001303272.1

ORF Insert Sequence:

ATGTTTAACT CACGTATCTT AACCAAATAT ACACTCTTAC TTGGACAAGA CGAAAACTCT 
GTTATAAAGA GTTTTACTGC ATCTGTAGAT CGGAAATTCA TCTCTTTGAT GTCATTAAGC 
TCTGATGGTT GTATATATGA AACCTTGATA CCAATACGTC CAGCTGACCC AGAAAAAAAT 
CAGAGCTTAG TTAAATCACT GCTGCTCAAG GCTGTTGTAT CTGGTAACGC TCGAAATGGA 
GTTGCACTCA CTGCCCTGGA TCAGGATCAC GTCGCAGTCC TAGGAAGTCC ACTAGCAGCT 
TCTAAGGAAT GCCTCTCTGT ATGGAACATA AAATTTCAAA CACTACAGAC TTCAAAAGAG 
TTACCACAAG GGACCAGTGG TCAACTCTGG TATTATGGAG AACATTTGTT TATGCTACAT 
GGAAAATCTC TAACTGTGAT TCCATACAAG TGTGAAGTGT CATCATTAGC AGGTGCTCTT 
GGAAAACTCA AGCATAGTCA AGATCCAGGA ACTCATGTCG TGTCCCATTT TGTAAACTGG 
GAGACACCTC AAGGATGTGG ACTTGGGTTC CAGAACTCAG AGCAGTCAAG AAGAATTTTA 
AGGAGACGAA AAATTGAAGT GAGTTTACAG CCAGAGGTTC CACCATCCAA ACAACTTTTG 
TCAACCATAA TGAAAGATTC AGAAAAACAC ATTGAAGTAG AAGTACGGAA ATTTTTGGCT 
CTGAAGCAGA CACCTGACTT TCATACTGTC ATTGGGGACA CAGTAACAGG ACTTCTGGAA 
AGGTGTAAAG CAGAACCATC ATTTTATCCC CGGAACTGTC TGATGCAGCT TATCCAAACG 
CATGTGCTTT CTTACAGTTT GTGCCCCGAC TTAATGGAGA TTGCCTTAAA AAAGAAAGAT 
GTACAGTTGT TACAACTCTG TCTACAGCAG TTCCCTGACA TTCCTGAATC AGTCACCTGT 
GCTTGCTTAA AAATTTTCTT GAGCATTGGT GATGACAGTC TTCAAGAAAC AGATGTTAAT 
ATGGAGTCAG TTTTTGACTA TAGTATAAAT TCTGTACATG ATGAGAAAAT GGAAGAGCAA 
ACTGAAATTC TTCAAAATGG CTTCAATCCT GAAGAAGATA AATGCAATAA CTGTGATCAA 
GAGTTAAATA AAAAGCCCCA GGACGAAACA AAGGAGAGCA CTTCATGCCC TGTGGTACAA 
AAAAGAGCAG CTCTACTTAA TGCAATTCTT CATTCAGCAT ATAGCGAGAC ATTTCTTCTG 
CCTCATTTGA AAGACATCCC AGCACAGCAT ATCACGCTGT TTCTTAAGTA TTTGTATTTC 
CTGTACCTGA AGTGTAGCGA AAATGCTACT ATGACTCTTC CTGGAATACA CCCACCTACC 
TTGAACCAGA TTATGGATTG GATATGTCTA CTTCTGGATG CAAATTTTAC TGTTGTTGTA 
ATGATGCCAG AAGCAAAGAG GCTACTGATA AATCTTTACA AGCTTGTAAA ATCTCAGATA 
TCTGTTTATT CTGAGCTCAA CAAGATTGAA GTAAGTTTTC GGGAGCTACA GAAATTAAAT 
CAAGAAAAGA ATAATAGAGG ATTATATTCA ATTGAAGTGC TGGAGCTCTT CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

NOL11 ( NM_015462.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_056277.2 Homo sapiens nucleolar protein 11 (NOL11), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu66639
Clone ID Related Accession (Same CDS sequence)	NM_015462.4 , NM_015462.5
Accession Version	NM_015462.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2160bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-02
Organism	Homo sapiens(human)
Product	nucleolar protein 11 isoform 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DA772356.1, AK023702.1, AK299483.1 and AW273123.1. On Dec 25, 2014 this sequence version replaced NM_015462.3. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). ##Evidence-Data-START## Transcript exon combination :: SRR1660803.81448.1, SRR1660809.103578.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCAGCGC TGGAGGAAGA ATTCACGTTG TCTTCGGTAG TCCTGAGCGC CGGGCCTGAA 
GGACTCCTAG GCGTGGAGCA GAGCGACAAA ACAGACCAGT TTCTAGTGAC AGACAGCGGC 
AGGACAGTCA TCCTCTATAA GGTTTCTGAT CAGAAACCCT TGGGGAGCTG GTCAGTGAAA 
CAAGGTCAAA TTATAACATG TCCAGCTGTG TGCAACTTTC AAACTGGAGA GTATGTTGTT 
GTACACGATA ATAAGGTTTT AAGAATATGG AATAATGAAG ATGTAAACCT GGATAAAGTA 
TTTAAAGCTA CATTGTCAGC AGAAGTATAT AGGATACTTT CAGTGCAAGG GACAGAACCC 
TTGGTGCTCT TCAAGGAAGG TGCTGTTCGT GGTTTAGAGG CCTTGCTTGC AGACCCCCAG 
CAGAAAATTG AAACTGTTAT CTCTGATGAA GAAGTGATTA AATGGACAAA GTTTTTCGTA 
GTATTCAGAC ATCCTGTTTT AATTTTTATT ACTGAAAAAC ATGGAAATTA CTTTGCTTAC 
GTGCAAATGT TTAACTCACG TATCTTAACC AAATATACAC TCTTACTTGG ACAAGACGAA 
AACTCTGTTA TAAAGAGTTT TACTGCATCT GTAGATCGGA AATTCATCTC TTTGATGTCA 
TTAAGCTCTG ATGGTTGTAT ATATGAAACC TTGATACCAA TACGTCCAGC TGACCCAGAA 
AAAAATCAGA GCTTAGTTAA ATCACTGCTG CTCAAGGCTG TTGTATCTGG TAACGCTCGA 
AATGGAGTTG CACTCACTGC CCTGGATCAG GATCACGTCG CAGTCCTAGG AAGTCCACTA 
GCAGCTTCTA AGGAATGCCT CTCTGTATGG AACATAAAAT TTCAAACACT ACAGACTTCA 
AAAGAGTTAC CACAAGGGAC CAGTGGTCAA CTCTGGTATT ATGGAGAACA TTTGTTTATG 
CTACATGGAA AATCTCTAAC TGTGATTCCA TACAAGTGTG AAGTGTCATC ATTAGCAGGT 
GCTCTTGGAA AACTCAAGCA TAGTCAAGAT CCAGGAACTC ATGTCGTGTC CCATTTTGTA 
AACTGGGAGA CACCTCAAGG ATGTGGACTT GGGTTCCAGA ACTCAGAGCA GTCAAGAAGA 
ATTTTAAGGA GACGAAAAAT TGAAGTGAGT TTACAGCCAG AGGTTCCACC ATCCAAACAA 
CTTTTGTCAA CCATAATGAA AGATTCAGAA AAACACATTG AAGTAGAAGT ACGGAAATTT 
TTGGCTCTGA AGCAGACACC TGACTTTCAT ACTGTCATTG GGGACACAGT AACAGGACTT 
CTGGAAAGGT GTAAAGCAGA ACCATCATTT TATCCCCGGA ACTGTCTGAT GCAGCTTATC 
CAAACGCATG TGCTTTCTTA CAGTTTGTGC CCCGACTTAA TGGAGATTGC CTTAAAAAAG 
AAAGATGTAC AGTTGTTACA ACTCTGTCTA CAGCAGTTCC CTGACATTCC TGAATCAGTC 
ACCTGTGCTT GCTTAAAAAT TTTCTTGAGC ATTGGTGATG ACAGTCTTCA AGAAACAGAT 
GTTAATATGG AGTCAGTTTT TGACTATAGT ATAAATTCTG TACATGATGA GAAAATGGAA 
GAGCAAACTG AAATTCTTCA AAATGGCTTC AATCCTGAAG AAGATAAATG CAATAACTGT 
GATCAAGAGT TAAATAAAAA GCCCCAGGAC GAAACAAAGG AGAGCACTTC ATGCCCTGTG 
GTACAAAAAA GAGCAGCTCT ACTTAATGCA ATTCTTCATT CAGCATATAG CGAGACATTT 
CTTCTGCCTC ATTTGAAAGA CATCCCAGCA CAGCATATCA CGCTGTTTCT TAAGTATTTG 
TATTTCCTGT ACCTGAAGTG TAGCGAAAAT GCTACTATGA CTCTTCCTGG AATACACCCA 
CCTACCTTGA ACCAGATTAT GGATTGGATA TGTCTACTTC TGGATGCAAA TTTTACTGTT 
GTTGTAATGA TGCCAGAAGC AAAGAGGCTA CTGATAAATC TTTACAAGCT TGTAAAATCT 
CAGATATCTG TTTATTCTGA GCTCAACAAG ATTGAAGTAA GTTTTCGGGA GCTACAGAAA 
TTAAATCAAG AAAAGAATAA TAGAGGATTA TATTCAATTG AAGTGCTGGA GCTCTTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_056277.2
CDS	116..2275
Translation	MAALEEEFTLSSVVLSAGPEGLLGVEQSDKTDQFLVTDSGRTVILYKVSDQKPLGSWSVKQGQIITCPAVCNFQTGEYVVVHDNKVLRIWNNEDVNLDKVFKATLSAEVYRILSVQGTEPLVLFKEGAVRGLEALLADPQQKIETVISDEEVIKWTKFFVVFRHPVLIFITEKHGNYFAYVQMFNSRILTKYTLLLGQDENSVIKSFTASVDRKFISLMSLSSDGCIYETLIPIRPADPEKNQSLVKSLLLKAVVSGNARNGVALTALDQDHVAVLGSPLAASKECLSVWNIKFQTLQTSKELPQGTSGQLWYYGEHLFMLHGKSLTVIPYKCEVSSLAGALGKLKHSQDPGTHVVSHFVNWETPQGCGLGFQNSEQSRRILRRRKIEVSLQPEVPPSKQLLSTIMKDSEKHIEVEVRKFLALKQTPDFHTVIGDTVTGLLERCKAEPSFYPRNCLMQLIQTHVLSYSLCPDLMEIALKKKDVQLLQLCLQQFPDIPESVTCACLKIFLSIGDDSLQETDVNMESVFDYSINSVHDEKMEEQTEILQNGFNPEEDKCNNCDQELNKKPQDETKESTSCPVVQKRAALLNAILHSAYSETFLLPHLKDIPAQHITLFLKYLYFLYLKCSENATMTLPGIHPPTLNQIMDWICLLLDANFTVVVMMPEAKRLLINLYKLVKSQISVYSELNKIEVSFRELQKLNQEKNNRGLYSIEVLELF

Target ORF information:

RefSeq Version	NM_015462.4
Organism	Homo sapiens(human)
Definition	Homo sapiens nucleolar protein 11 (NOL11), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_015462.4

ORF Insert Sequence:

ATGGCAGCGC TGGAGGAAGA ATTCACGTTG TCTTCGGTAG TCCTGAGCGC CGGGCCTGAA 
GGACTCCTAG GCGTGGAGCA GAGCGACAAA ACAGACCAGT TTCTAGTGAC AGACAGCGGC 
AGGACAGTCA TCCTCTATAA GGTTTCTGAT CAGAAACCCT TGGGGAGCTG GTCAGTGAAA 
CAAGGTCAAA TTATAACATG TCCAGCTGTG TGCAACTTTC AAACTGGAGA GTATGTTGTT 
GTACACGATA ATAAGGTTTT AAGAATATGG AATAATGAAG ATGTAAACCT GGATAAAGTA 
TTTAAAGCTA CATTGTCAGC AGAAGTATAT AGGATACTTT CAGTGCAAGG GACAGAACCC 
TTGGTGCTCT TCAAGGAAGG TGCTGTTCGT GGTTTAGAGG CCTTGCTTGC AGACCCCCAG 
CAGAAAATTG AAACTGTTAT CTCTGATGAA GAAGTGATTA AATGGACAAA GTTTTTCGTA 
GTATTCAGAC ATCCTGTTTT AATTTTTATT ACTGAAAAAC ATGGAAATTA CTTTGCTTAC 
GTGCAAATGT TTAACTCACG TATCTTAACC AAATATACAC TCTTACTTGG ACAAGACGAA 
AACTCTGTTA TAAAGAGTTT TACTGCATCT GTAGATCGGA AATTCATCTC TTTGATGTCA 
TTAAGCTCTG ATGGTTGTAT ATATGAAACC TTGATACCAA TACGTCCAGC TGACCCAGAA 
AAAAATCAGA GCTTAGTTAA ATCACTGCTG CTCAAGGCTG TTGTATCTGG TAACGCTCGA 
AATGGAGTTG CACTCACTGC CCTGGATCAG GATCACGTCG CAGTCCTAGG AAGTCCACTA 
GCAGCTTCTA AGGAATGCCT CTCTGTATGG AACATAAAAT TTCAAACACT ACAGACTTCA 
AAAGAGTTAC CACAAGGGAC CAGTGGTCAA CTCTGGTATT ATGGAGAACA TTTGTTTATG 
CTACATGGAA AATCTCTAAC TGTGATTCCA TACAAGTGTG AAGTGTCATC ATTAGCAGGT 
GCTCTTGGAA AACTCAAGCA TAGTCAAGAT CCAGGAACTC ATGTCGTGTC CCATTTTGTA 
AACTGGGAGA CACCTCAAGG ATGTGGACTT GGGTTCCAGA ACTCAGAGCA GTCAAGAAGA 
ATTTTAAGGA GACGAAAAAT TGAAGTGAGT TTACAGCCAG AGGTTCCACC ATCCAAACAA 
CTTTTGTCAA CCATAATGAA AGATTCAGAA AAACACATTG AAGTAGAAGT ACGGAAATTT 
TTGGCTCTGA AGCAGACACC TGACTTTCAT ACTGTCATTG GGGACACAGT AACAGGACTT 
CTGGAAAGGT GTAAAGCAGA ACCATCATTT TATCCCCGGA ACTGTCTGAT GCAGCTTATC 
CAAACGCATG TGCTTTCTTA CAGTTTGTGC CCCGACTTAA TGGAGATTGC CTTAAAAAAG 
AAAGATGTAC AGTTGTTACA ACTCTGTCTA CAGCAGTTCC CTGACATTCC TGAATCAGTC 
ACCTGTGCTT GCTTAAAAAT TTTCTTGAGC ATTGGTGATG ACAGTCTTCA AGAAACAGAT 
GTTAATATGG AGTCAGTTTT TGACTATAGT ATAAATTCTG TACATGATGA GAAAATGGAA 
GAGCAAACTG AAATTCTTCA AAATGGCTTC AATCCTGAAG AAGATAAATG CAATAACTGT 
GATCAAGAGT TAAATAAAAA GCCCCAGGAC GAAACAAAGG AGAGCACTTC ATGCCCTGTG 
GTACAAAAAA GAGCAGCTCT ACTTAATGCA ATTCTTCATT CAGCATATAG CGAGACATTT 
CTTCTGCCTC ATTTGAAAGA CATCCCAGCA CAGCATATCA CGCTGTTTCT TAAGTATTTG 
TATTTCCTGT ACCTGAAGTG TAGCGAAAAT GCTACTATGA CTCTTCCTGG AATACACCCA 
CCTACCTTGA ACCAGATTAT GGATTGGATA TGTCTACTTC TGGATGCAAA TTTTACTGTT 
GTTGTAATGA TGCCAGAAGC AAAGAGGCTA CTGATAAATC TTTACAAGCT TGTAAAATCT 
CAGATATCTG TTTATTCTGA GCTCAACAAG ATTGAAGTAA GTTTTCGGGA GCTACAGAAA 
TTAAATCAAG AAAAGAATAA TAGAGGATTA TATTCAATTG AAGTGCTGGA GCTCTTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

NOL11 ( NM_015462.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_056277.2 Homo sapiens nucleolar protein 11 (NOL11), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu66639
Clone ID Related Accession (Same CDS sequence)	NM_015462.4 , NM_015462.5
Accession Version	NM_015462.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2160bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-09
Organism	Homo sapiens(human)
Product	nucleolar protein 11 isoform 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DA772356.1, AK023702.1, AK299483.1, AW273123.1 and AC006534.10. On Nov 23, 2018 this sequence version replaced NM_015462.4. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). ##Evidence-Data-START## Transcript exon combination :: SRR1803613.20070.1, SRR1803613.1671.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000253247.9/ ENSP00000253247.4 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCAGCGC TGGAGGAAGA ATTCACGTTG TCTTCGGTAG TCCTGAGCGC CGGGCCTGAA 
GGACTCCTAG GCGTGGAGCA GAGCGACAAA ACAGACCAGT TTCTAGTGAC AGACAGCGGC 
AGGACAGTCA TCCTCTATAA GGTTTCTGAT CAGAAACCCT TGGGGAGCTG GTCAGTGAAA 
CAAGGTCAAA TTATAACATG TCCAGCTGTG TGCAACTTTC AAACTGGAGA GTATGTTGTT 
GTACACGATA ATAAGGTTTT AAGAATATGG AATAATGAAG ATGTAAACCT GGATAAAGTA 
TTTAAAGCTA CATTGTCAGC AGAAGTATAT AGGATACTTT CAGTGCAAGG GACAGAACCC 
TTGGTGCTCT TCAAGGAAGG TGCTGTTCGT GGTTTAGAGG CCTTGCTTGC AGACCCCCAG 
CAGAAAATTG AAACTGTTAT CTCTGATGAA GAAGTGATTA AATGGACAAA GTTTTTCGTA 
GTATTCAGAC ATCCTGTTTT AATTTTTATT ACTGAAAAAC ATGGAAATTA CTTTGCTTAC 
GTGCAAATGT TTAACTCACG TATCTTAACC AAATATACAC TCTTACTTGG ACAAGACGAA 
AACTCTGTTA TAAAGAGTTT TACTGCATCT GTAGATCGGA AATTCATCTC TTTGATGTCA 
TTAAGCTCTG ATGGTTGTAT ATATGAAACC TTGATACCAA TACGTCCAGC TGACCCAGAA 
AAAAATCAGA GCTTAGTTAA ATCACTGCTG CTCAAGGCTG TTGTATCTGG TAACGCTCGA 
AATGGAGTTG CACTCACTGC CCTGGATCAG GATCACGTCG CAGTCCTAGG AAGTCCACTA 
GCAGCTTCTA AGGAATGCCT CTCTGTATGG AACATAAAAT TTCAAACACT ACAGACTTCA 
AAAGAGTTAC CACAAGGGAC CAGTGGTCAA CTCTGGTATT ATGGAGAACA TTTGTTTATG 
CTACATGGAA AATCTCTAAC TGTGATTCCA TACAAGTGTG AAGTGTCATC ATTAGCAGGT 
GCTCTTGGAA AACTCAAGCA TAGTCAAGAT CCAGGAACTC ATGTCGTGTC CCATTTTGTA 
AACTGGGAGA CACCTCAAGG ATGTGGACTT GGGTTCCAGA ACTCAGAGCA GTCAAGAAGA 
ATTTTAAGGA GACGAAAAAT TGAAGTGAGT TTACAGCCAG AGGTTCCACC ATCCAAACAA 
CTTTTGTCAA CCATAATGAA AGATTCAGAA AAACACATTG AAGTAGAAGT ACGGAAATTT 
TTGGCTCTGA AGCAGACACC TGACTTTCAT ACTGTCATTG GGGACACAGT AACAGGACTT 
CTGGAAAGGT GTAAAGCAGA ACCATCATTT TATCCCCGGA ACTGTCTGAT GCAGCTTATC 
CAAACGCATG TGCTTTCTTA CAGTTTGTGC CCCGACTTAA TGGAGATTGC CTTAAAAAAG 
AAAGATGTAC AGTTGTTACA ACTCTGTCTA CAGCAGTTCC CTGACATTCC TGAATCAGTC 
ACCTGTGCTT GCTTAAAAAT TTTCTTGAGC ATTGGTGATG ACAGTCTTCA AGAAACAGAT 
GTTAATATGG AGTCAGTTTT TGACTATAGT ATAAATTCTG TACATGATGA GAAAATGGAA 
GAGCAAACTG AAATTCTTCA AAATGGCTTC AATCCTGAAG AAGATAAATG CAATAACTGT 
GATCAAGAGT TAAATAAAAA GCCCCAGGAC GAAACAAAGG AGAGCACTTC ATGCCCTGTG 
GTACAAAAAA GAGCAGCTCT ACTTAATGCA ATTCTTCATT CAGCATATAG CGAGACATTT 
CTTCTGCCTC ATTTGAAAGA CATCCCAGCA CAGCATATCA CGCTGTTTCT TAAGTATTTG 
TATTTCCTGT ACCTGAAGTG TAGCGAAAAT GCTACTATGA CTCTTCCTGG AATACACCCA 
CCTACCTTGA ACCAGATTAT GGATTGGATA TGTCTACTTC TGGATGCAAA TTTTACTGTT 
GTTGTAATGA TGCCAGAAGC AAAGAGGCTA CTGATAAATC TTTACAAGCT TGTAAAATCT 
CAGATATCTG TTTATTCTGA GCTCAACAAG ATTGAAGTAA GTTTTCGGGA GCTACAGAAA 
TTAAATCAAG AAAAGAATAA TAGAGGATTA TATTCAATTG AAGTGCTGGA GCTCTTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_056277.2
CDS	13..2172
Translation	MAALEEEFTLSSVVLSAGPEGLLGVEQSDKTDQFLVTDSGRTVILYKVSDQKPLGSWSVKQGQIITCPAVCNFQTGEYVVVHDNKVLRIWNNEDVNLDKVFKATLSAEVYRILSVQGTEPLVLFKEGAVRGLEALLADPQQKIETVISDEEVIKWTKFFVVFRHPVLIFITEKHGNYFAYVQMFNSRILTKYTLLLGQDENSVIKSFTASVDRKFISLMSLSSDGCIYETLIPIRPADPEKNQSLVKSLLLKAVVSGNARNGVALTALDQDHVAVLGSPLAASKECLSVWNIKFQTLQTSKELPQGTSGQLWYYGEHLFMLHGKSLTVIPYKCEVSSLAGALGKLKHSQDPGTHVVSHFVNWETPQGCGLGFQNSEQSRRILRRRKIEVSLQPEVPPSKQLLSTIMKDSEKHIEVEVRKFLALKQTPDFHTVIGDTVTGLLERCKAEPSFYPRNCLMQLIQTHVLSYSLCPDLMEIALKKKDVQLLQLCLQQFPDIPESVTCACLKIFLSIGDDSLQETDVNMESVFDYSINSVHDEKMEEQTEILQNGFNPEEDKCNNCDQELNKKPQDETKESTSCPVVQKRAALLNAILHSAYSETFLLPHLKDIPAQHITLFLKYLYFLYLKCSENATMTLPGIHPPTLNQIMDWICLLLDANFTVVVMMPEAKRLLINLYKLVKSQISVYSELNKIEVSFRELQKLNQEKNNRGLYSIEVLELF

Target ORF information:

RefSeq Version	NM_015462.5
Organism	Homo sapiens(human)
Definition	Homo sapiens nucleolar protein 11 (NOL11), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_015462.5

ORF Insert Sequence:

ATGGCAGCGC TGGAGGAAGA ATTCACGTTG TCTTCGGTAG TCCTGAGCGC CGGGCCTGAA 
GGACTCCTAG GCGTGGAGCA GAGCGACAAA ACAGACCAGT TTCTAGTGAC AGACAGCGGC 
AGGACAGTCA TCCTCTATAA GGTTTCTGAT CAGAAACCCT TGGGGAGCTG GTCAGTGAAA 
CAAGGTCAAA TTATAACATG TCCAGCTGTG TGCAACTTTC AAACTGGAGA GTATGTTGTT 
GTACACGATA ATAAGGTTTT AAGAATATGG AATAATGAAG ATGTAAACCT GGATAAAGTA 
TTTAAAGCTA CATTGTCAGC AGAAGTATAT AGGATACTTT CAGTGCAAGG GACAGAACCC 
TTGGTGCTCT TCAAGGAAGG TGCTGTTCGT GGTTTAGAGG CCTTGCTTGC AGACCCCCAG 
CAGAAAATTG AAACTGTTAT CTCTGATGAA GAAGTGATTA AATGGACAAA GTTTTTCGTA 
GTATTCAGAC ATCCTGTTTT AATTTTTATT ACTGAAAAAC ATGGAAATTA CTTTGCTTAC 
GTGCAAATGT TTAACTCACG TATCTTAACC AAATATACAC TCTTACTTGG ACAAGACGAA 
AACTCTGTTA TAAAGAGTTT TACTGCATCT GTAGATCGGA AATTCATCTC TTTGATGTCA 
TTAAGCTCTG ATGGTTGTAT ATATGAAACC TTGATACCAA TACGTCCAGC TGACCCAGAA 
AAAAATCAGA GCTTAGTTAA ATCACTGCTG CTCAAGGCTG TTGTATCTGG TAACGCTCGA 
AATGGAGTTG CACTCACTGC CCTGGATCAG GATCACGTCG CAGTCCTAGG AAGTCCACTA 
GCAGCTTCTA AGGAATGCCT CTCTGTATGG AACATAAAAT TTCAAACACT ACAGACTTCA 
AAAGAGTTAC CACAAGGGAC CAGTGGTCAA CTCTGGTATT ATGGAGAACA TTTGTTTATG 
CTACATGGAA AATCTCTAAC TGTGATTCCA TACAAGTGTG AAGTGTCATC ATTAGCAGGT 
GCTCTTGGAA AACTCAAGCA TAGTCAAGAT CCAGGAACTC ATGTCGTGTC CCATTTTGTA 
AACTGGGAGA CACCTCAAGG ATGTGGACTT GGGTTCCAGA ACTCAGAGCA GTCAAGAAGA 
ATTTTAAGGA GACGAAAAAT TGAAGTGAGT TTACAGCCAG AGGTTCCACC ATCCAAACAA 
CTTTTGTCAA CCATAATGAA AGATTCAGAA AAACACATTG AAGTAGAAGT ACGGAAATTT 
TTGGCTCTGA AGCAGACACC TGACTTTCAT ACTGTCATTG GGGACACAGT AACAGGACTT 
CTGGAAAGGT GTAAAGCAGA ACCATCATTT TATCCCCGGA ACTGTCTGAT GCAGCTTATC 
CAAACGCATG TGCTTTCTTA CAGTTTGTGC CCCGACTTAA TGGAGATTGC CTTAAAAAAG 
AAAGATGTAC AGTTGTTACA ACTCTGTCTA CAGCAGTTCC CTGACATTCC TGAATCAGTC 
ACCTGTGCTT GCTTAAAAAT TTTCTTGAGC ATTGGTGATG ACAGTCTTCA AGAAACAGAT 
GTTAATATGG AGTCAGTTTT TGACTATAGT ATAAATTCTG TACATGATGA GAAAATGGAA 
GAGCAAACTG AAATTCTTCA AAATGGCTTC AATCCTGAAG AAGATAAATG CAATAACTGT 
GATCAAGAGT TAAATAAAAA GCCCCAGGAC GAAACAAAGG AGAGCACTTC ATGCCCTGTG 
GTACAAAAAA GAGCAGCTCT ACTTAATGCA ATTCTTCATT CAGCATATAG CGAGACATTT 
CTTCTGCCTC ATTTGAAAGA CATCCCAGCA CAGCATATCA CGCTGTTTCT TAAGTATTTG 
TATTTCCTGT ACCTGAAGTG TAGCGAAAAT GCTACTATGA CTCTTCCTGG AATACACCCA 
CCTACCTTGA ACCAGATTAT GGATTGGATA TGTCTACTTC TGGATGCAAA TTTTACTGTT 
GTTGTAATGA TGCCAGAAGC AAAGAGGCTA CTGATAAATC TTTACAAGCT TGTAAAATCT 
CAGATATCTG TTTATTCTGA GCTCAACAAG ATTGAAGTAA GTTTTCGGGA GCTACAGAAA 
TTAAATCAAG AAAAGAATAA TAGAGGATTA TATTCAATTG AAGTGCTGGA GCTCTTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Architecture of the human interactome defines protein communities and disease networks.
Nature545(7655)505-509(2017 05)
Huttlin EL,Bruckner RJ,Paulo JA,Cannon JR,Ting L,Baltier K,Colby G,Gebreab F,Gygi MP,Parzen H,Szpyt J,Tam S,Zarraga G,Pontano-Vaites L,Swarup S,White AE,Schweppe DK,Rad R,Erickson BK,Obar RA,Guruharsha KG,Li K,Artavanis-Tsakonas S,Gygi SP,Harper JW

GABRA1 and STXBP1: novel genetic causes of Dravet syndrome.
Neurology82(14)1245-53(2014 Apr)
Carvill GL,Weckhuysen S,McMahon JM,Hartmann C,M?ller RS,Hjalgrim H,Cook J,Geraghty E,O'Roak BJ,Petrou S,Clarke A,Gill D,Sadleir LG,Muhle H,von Spiczak S,Nikanorova M,Hodgson BL,Gazina EV,Suls A,Shendure J,Dibbens LM,De Jonghe P,Helbig I,Berkovic SF,Scheffer IE,Mefford HC

Insights into RNA biology from an atlas of mammalian mRNA-binding proteins.
Cell149(6)1393-406(2012 Jun)
Castello A,Fischer B,Eichelbaum K,Horos R,Beckmann BM,Strein C,Davey NE,Humphreys DT,Preiss T,Steinmetz LM,Krijgsveld J,Hentze MW

The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.
Molecular cell46(5)674-90(2012 Jun)
Baltz AG,Munschauer M,Schwanh?usser B,Vasile A,Murakawa Y,Schueler M,Youngs N,Penfold-Brown D,Drew K,Milek M,Wyler E,Bonneau R,Selbach M,Dieterich C,Landthaler M

NOL11, implicated in the pathogenesis of North American Indian childhood cirrhosis, is required for pre-rRNA transcription and processing.
PLoS genetics8(8)e1002892(2012)
Freed EF,Prieto JL,McCann KL,McStay B,Baserga SJ

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NOL11 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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見積依頼

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FAX

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