ALX3 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	ALX3
Entrez Gene ID	257
Full Name	ALX homeobox 3
Synonyms	FND,FND1
General protein information	Preferred Names ALX homeobox 3 Names homeobox protein aristaless-like 3 aristaless-like homeobox 3 frontonasal dysplasia proline-rich transcription factor ALX3
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 1 Map Location: 1p13.3
Summary	This gene encodes a nuclear protein with a homeobox DNA-binding domain that functions as a transcriptional regulator involved in cell-type differentiation and development. Preferential methylation of this gene's promoter is associated with advanced-stage neuroblastoma tumors. [provided by RefSeq, Jul 2008].
Disorder MIM:	606014
Disorder Html:	Frontonasal dysplasia 1, 136760 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_006492.2	NP_006483.2	homeobox protein aristaless-like 3
NM_006492.3	NP_006483.2	homeobox protein aristaless-like 3

Pathways from BioSystems

Homologies

	ALX3	XP_001099295.1
Canis lupus familiaris (dog)	ALX3	XP_005621859.1
Bos taurus (cattle)	ALX3	NP_001179482.1
Gallus gallus (chicken)	ALX3	XP_003642783.2
Homo sapiens (human)	ALX3	NP_006483.2
Pan troglodytes (chimpanzee)	ALX3	XP_524801.2
Mus musculus (house mouse)	Alx3	NP_031467.1
Rattus norvegicus (Norway rat)	Alx3	NP_001007013.1
Danio rerio (zebrafish)	LOC566955	XP_005167168.1

Gene Ontology
Bibliography

Related articles in PubMed

Exome sequencing revealed a novel nonsense variant in ALX3 gene underlying frontorhiny.
Ullah A, Umair M, E-Kalsoom U, Shahzad S, Basit S, Ahmad W
Journal of human genetics63(1)97-100(2018 Jan)

An atlas of genetic influences on human blood metabolites.
Shin SY, Fauman EB, Petersen AK, Krumsiek J, Santos R, Huang J, Arnold M, Erte I, Forgetta V, Yang TP, Walter K, Menni C, Chen L, Vasquez L, Valdes AM, Hyde CL, Wang V, Ziemek D, Roberts P, Xi L, Grundberg E, , Waldenberger M, Richards JB, Mohney RP, Milburn MV, John SL, Trimmer J, Theis FJ, Overington JP, Suhre K, Brosnan MJ, Gieger C, Kastenm?ller G, Spector TD, Soranzo N
Nature genetics46(6)543-550(2014 Jun)

Exclusion of mutations in TGIF, ALX3, and ALX4 genes in patients with the syndrome of frontonasal dysgenesis, callosal agenesis, basal encephalocele, and eye anomalies.
Ribeiro-Bicudo LA, Quiezi RG, Guion-Almeida ML, Legnaro C, Richieri-Costa A
American journal of medical genetics. Part A158A(5)1233-5(2012 May)

Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
Fox CS, Liu Y, White CC, Feitosa M, Smith AV, Heard-Costa N, Lohman K, , , , Johnson AD, Foster MC, Greenawalt DM, Griffin P, Ding J, Newman AB, Tylavsky F, Miljkovic I, Kritchevsky SB, Launer L, Garcia M, Eiriksdottir G, Carr JJ, Gudnason V, Harris TB, Cupples LA, Borecki IB
PLoS genetics8(5)e1002695(2012)

Clinical and genetic characterization of frontorhiny: report of 3 novel cases and discussion of the surgical management.
Pham NS, Rafii A, Liu J, Boyadjiev SA, Tollefson TT
Archives of facial plastic surgery13(6)415-20(2011 Nov-Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Exclusion of mutations in ALX3 gene in patients with the syndrome of frontonasal dysgenesis, callosal agenesis, basal encephalocele, and eye anomalies
Title: Exclusion of mutations in TGIF, ALX3, and ALX4 genes in patients with the syndrome of frontonasal dysgenesis, callosal agenesis, basal encephalocele, and eye anomalies.

We report a novel Y214X mutation in ALX3 in frontorhiny.
Title: Clinical and genetic characterization of frontorhiny: report of 3 novel cases and discussion of the surgical management.

Observational study of gene-disease association. (HuGE Navigator)
Title: Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia.

ALX3 is essential for normal facial development in humans and that deficiency causes a clinically recognizable phenotype, which we term frontorhiny.
Title: Frontorhiny, a distinctive presentation of frontonasal dysplasia caused by recessive mutations in the ALX3 homeobox gene.

Chromatin immunoprecipitation assays indicated that Alx3 in mouse pancreatic islets occupies the promoter of the mouse insulin genes.
Title: The homeoprotein Alx3 expressed in pancreatic beta-cells regulates insulin gene transcription by interacting with the basic helix-loop-helix protein E47.

The following ALX3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ALX3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu19546	NM_006492.3 Latest version!	Homo sapiens ALX homeobox 3 (ALX3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$223.30 $319.00
View Old Accession Versions >>
OHu19546	NM_006492.2	Homo sapiens ALX homeobox 3 (ALX3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$223.30 $319.00
Hide Old Accession Versions >>

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

ALX3 ( NM_006492.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_006483.2 Homo sapiens ALX homeobox 3 (ALX3), mRNA.

Price & Availability↑

CloneID	OHu19546
Clone ID Related Accession (Same CDS sequence)	NM_006492.2 , NM_006492.3
Accession Version	NM_006492.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1032bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	homeobox protein aristaless-like 3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC113428.1. This sequence is a reference standard in the RefSeqGene project. On Aug 25, 2006 this sequence version replaced NM_006492.1. ##Evidence-Data-START## Transcript exon combination :: BC113428.1, BC112007.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1968189 [ECO:0000350] ##Evidence-Data-END##

ATGGACCCCG AGCACTGCGC GCCTTTCCGC GTGGGGCCTG CACCCGGCCC CTATGTGGCC 
TCGGGGGACG AGCCTCCGGG CCCGCAGGGA ACCCCCGCCG CTGCGCCTCA CCTGCACCCC 
GCGCCGCCCC GCGGCCCGCG GCTGACCCGC TTTCCGGCCT GCGGGCCCCT GGAGCCCTAC 
CTCCCAGAGC CGGCCAAGCC GCCCGCCAAG TACCTGCAGG ACCTCGGGCC CGGCCCGGCC 
CTCAACGGCG GCCACTTCTA CGAGGGCCCC GCGGAAGCTG AGGAGAAGAC CTCCAAAGCT 
GCCAGCTTCC CCCAGCTGCC CTTGGACTGC CGAGGGGGCC CCAGAGACGG GCCCTCTAAC 
TTGCAAGGCT CCCCAGGCCC CTGCCTGGCC AGCCTGCATC TTCCTCTTTC CCCGGGACTC 
CCTGACTCCA TGGAGTTGGC CAAGAACAAG AGCAAGAAGC GTCGTAACCG CACGACCTTC 
AGCACATTCC AGCTGGAGGA GCTGGAGAAG GTCTTCCAGA AAACCCACTA TCCTGATGTG 
TATGCCCGGG AGCAGCTGGC CCTGCGCACA GACCTGACTG AGGCCCGGGT ACAGGTCTGG 
TTCCAGAACC GCAGAGCCAA GTGGCGGAAG CGCGAGCGTT ATGGGAAGAT CCAGGAGGGG 
CGGAACCCCT TCACGGCTGC CTATGACATC TCTGTGCTGC CCCGTACTGA CAGCCACCCT 
CAGCTGCAGA ACTCCCTGTG GGCCAGTCCA GGATCTGGGA GCCCTGGAGG CCCCTGCCTT 
GTGTCTCCAG AGGGCATCCC CTCCCCATGC ATGTCTCCAT ATTCCCACCC CCATGGGAGT 
GTGGCTGGCT TCATGGGGGT GCCAGCCCCT TCTGCGGCTC ACCCTGGCAT CTACTCCATC 
CATGGCTTTC CCCCCACCCT GGGGGGCCAC AGCTTTGAGC CTTCCTCAGA TGGTGACTAT 
AAGTCTCCAA GCCTCGTCTC GCTCAGGGTA AAGCCCAAGG AGCCACCCGG CCTTCTGAAC 
TGGACCACGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006483.2
CDS	89..1120
Translation	MDPEHCAPFRVGPAPGPYVASGDEPPGPQGTPAAAPHLHPAPPRGPRLTRFPACGPLEPYLPEPAKPPAKYLQDLGPGPALNGGHFYEGPAEAEEKTSKAASFPQLPLDCRGGPRDGPSNLQGSPGPCLASLHLPLSPGLPDSMELAKNKSKKRRNRTTFSTFQLEELEKVFQKTHYPDVYAREQLALRTDLTEARVQVWFQNRRAKWRKRERYGKIQEGRNPFTAAYDISVLPRTDSHPQLQNSLWASPGSGSPGGPCLVSPEGIPSPCMSPYSHPHGSVAGFMGVPAPSAAHPGIYSIHGFPPTLGGHSFEPSSDGDYKSPSLVSLRVKPKEPPGLLNWTT

Target ORF information:

RefSeq Version	NM_006492.2
Organism	Homo sapiens(human)
Definition	Homo sapiens ALX homeobox 3 (ALX3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006492.2

ORF Insert Sequence:

ATGGACCCCG AGCACTGCGC GCCTTTCCGC GTGGGGCCTG CACCCGGCCC CTATGTGGCC 
TCGGGGGACG AGCCTCCGGG CCCGCAGGGA ACCCCCGCCG CTGCGCCTCA CCTGCACCCC 
GCGCCGCCCC GCGGCCCGCG GCTGACCCGC TTTCCGGCCT GCGGGCCCCT GGAGCCCTAC 
CTCCCAGAGC CGGCCAAGCC GCCCGCCAAG TACCTGCAGG ACCTCGGGCC CGGCCCGGCC 
CTCAACGGCG GCCACTTCTA CGAGGGCCCC GCGGAAGCTG AGGAGAAGAC CTCCAAAGCT 
GCCAGCTTCC CCCAGCTGCC CTTGGACTGC CGAGGGGGCC CCAGAGACGG GCCCTCTAAC 
TTGCAAGGCT CCCCAGGCCC CTGCCTGGCC AGCCTGCATC TTCCTCTTTC CCCGGGACTC 
CCTGACTCCA TGGAGTTGGC CAAGAACAAG AGCAAGAAGC GTCGTAACCG CACGACCTTC 
AGCACATTCC AGCTGGAGGA GCTGGAGAAG GTCTTCCAGA AAACCCACTA TCCTGATGTG 
TATGCCCGGG AGCAGCTGGC CCTGCGCACA GACCTGACTG AGGCCCGGGT ACAGGTCTGG 
TTCCAGAACC GCAGAGCCAA GTGGCGGAAG CGCGAGCGTT ATGGGAAGAT CCAGGAGGGG 
CGGAACCCCT TCACGGCTGC CTATGACATC TCTGTGCTGC CCCGTACTGA CAGCCACCCT 
CAGCTGCAGA ACTCCCTGTG GGCCAGTCCA GGATCTGGGA GCCCTGGAGG CCCCTGCCTT 
GTGTCTCCAG AGGGCATCCC CTCCCCATGC ATGTCTCCAT ATTCCCACCC CCATGGGAGT 
GTGGCTGGCT TCATGGGGGT GCCAGCCCCT TCTGCGGCTC ACCCTGGCAT CTACTCCATC 
CATGGCTTTC CCCCCACCCT GGGGGGCCAC AGCTTTGAGC CTTCCTCAGA TGGTGACTAT 
AAGTCTCCAA GCCTCGTCTC GCTCAGGGTA AAGCCCAAGG AGCCACCCGG CCTTCTGAAC 
TGGACCACGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ALX3 ( NM_006492.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_006483.2 Homo sapiens ALX homeobox 3 (ALX3), mRNA.

Price & Availability↑

CloneID	OHu19546
Clone ID Related Accession (Same CDS sequence)	NM_006492.2 , NM_006492.3
Accession Version	NM_006492.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1032bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-20
Organism	Homo sapiens(human)
Product	homeobox protein aristaless-like 3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC113428.1 and AL160006.16. This sequence is a reference standard in the RefSeqGene project. On Jul 31, 2018 this sequence version replaced NM_006492.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC113428.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1968189 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000647563.2/ ENSP00000497310.1 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##

ATGGACCCCG AGCACTGCGC GCCTTTCCGC GTGGGGCCTG CACCCGGCCC CTATGTGGCC 
TCGGGGGACG AGCCTCCGGG CCCGCAGGGA ACCCCCGCCG CTGCGCCTCA CCTGCACCCC 
GCGCCGCCCC GCGGCCCGCG GCTGACCCGC TTTCCGGCCT GCGGGCCCCT GGAGCCCTAC 
CTCCCAGAGC CGGCCAAGCC GCCCGCCAAG TACCTGCAGG ACCTCGGGCC CGGCCCGGCC 
CTCAACGGCG GCCACTTCTA CGAGGGCCCC GCGGAAGCTG AGGAGAAGAC CTCCAAAGCT 
GCCAGCTTCC CCCAGCTGCC CTTGGACTGC CGAGGGGGCC CCAGAGACGG GCCCTCTAAC 
TTGCAAGGCT CCCCAGGCCC CTGCCTGGCC AGCCTGCATC TTCCTCTTTC CCCGGGACTC 
CCTGACTCCA TGGAGTTGGC CAAGAACAAG AGCAAGAAGC GTCGTAACCG CACGACCTTC 
AGCACATTCC AGCTGGAGGA GCTGGAGAAG GTCTTCCAGA AAACCCACTA TCCTGATGTG 
TATGCCCGGG AGCAGCTGGC CCTGCGCACA GACCTGACTG AGGCCCGGGT ACAGGTCTGG 
TTCCAGAACC GCAGAGCCAA GTGGCGGAAG CGCGAGCGTT ATGGGAAGAT CCAGGAGGGG 
CGGAACCCCT TCACGGCTGC CTATGACATC TCTGTGCTGC CCCGTACTGA CAGCCACCCT 
CAGCTGCAGA ACTCCCTGTG GGCCAGTCCA GGATCTGGGA GCCCTGGAGG CCCCTGCCTT 
GTGTCTCCAG AGGGCATCCC CTCCCCATGC ATGTCTCCAT ATTCCCACCC CCATGGGAGT 
GTGGCTGGCT TCATGGGGGT GCCAGCCCCT TCTGCGGCTC ACCCTGGCAT CTACTCCATC 
CATGGCTTTC CCCCCACCCT GGGGGGCCAC AGCTTTGAGC CTTCCTCAGA TGGTGACTAT 
AAGTCTCCAA GCCTCGTCTC GCTCAGGGTA AAGCCCAAGG AGCCACCCGG CCTTCTGAAC 
TGGACCACGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006483.2
CDS	61..1092
Translation	MDPEHCAPFRVGPAPGPYVASGDEPPGPQGTPAAAPHLHPAPPRGPRLTRFPACGPLEPYLPEPAKPPAKYLQDLGPGPALNGGHFYEGPAEAEEKTSKAASFPQLPLDCRGGPRDGPSNLQGSPGPCLASLHLPLSPGLPDSMELAKNKSKKRRNRTTFSTFQLEELEKVFQKTHYPDVYAREQLALRTDLTEARVQVWFQNRRAKWRKRERYGKIQEGRNPFTAAYDISVLPRTDSHPQLQNSLWASPGSGSPGGPCLVSPEGIPSPCMSPYSHPHGSVAGFMGVPAPSAAHPGIYSIHGFPPTLGGHSFEPSSDGDYKSPSLVSLRVKPKEPPGLLNWTT

Target ORF information:

RefSeq Version	NM_006492.3
Organism	Homo sapiens(human)
Definition	Homo sapiens ALX homeobox 3 (ALX3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006492.3

ORF Insert Sequence:

ATGGACCCCG AGCACTGCGC GCCTTTCCGC GTGGGGCCTG CACCCGGCCC CTATGTGGCC 
TCGGGGGACG AGCCTCCGGG CCCGCAGGGA ACCCCCGCCG CTGCGCCTCA CCTGCACCCC 
GCGCCGCCCC GCGGCCCGCG GCTGACCCGC TTTCCGGCCT GCGGGCCCCT GGAGCCCTAC 
CTCCCAGAGC CGGCCAAGCC GCCCGCCAAG TACCTGCAGG ACCTCGGGCC CGGCCCGGCC 
CTCAACGGCG GCCACTTCTA CGAGGGCCCC GCGGAAGCTG AGGAGAAGAC CTCCAAAGCT 
GCCAGCTTCC CCCAGCTGCC CTTGGACTGC CGAGGGGGCC CCAGAGACGG GCCCTCTAAC 
TTGCAAGGCT CCCCAGGCCC CTGCCTGGCC AGCCTGCATC TTCCTCTTTC CCCGGGACTC 
CCTGACTCCA TGGAGTTGGC CAAGAACAAG AGCAAGAAGC GTCGTAACCG CACGACCTTC 
AGCACATTCC AGCTGGAGGA GCTGGAGAAG GTCTTCCAGA AAACCCACTA TCCTGATGTG 
TATGCCCGGG AGCAGCTGGC CCTGCGCACA GACCTGACTG AGGCCCGGGT ACAGGTCTGG 
TTCCAGAACC GCAGAGCCAA GTGGCGGAAG CGCGAGCGTT ATGGGAAGAT CCAGGAGGGG 
CGGAACCCCT TCACGGCTGC CTATGACATC TCTGTGCTGC CCCGTACTGA CAGCCACCCT 
CAGCTGCAGA ACTCCCTGTG GGCCAGTCCA GGATCTGGGA GCCCTGGAGG CCCCTGCCTT 
GTGTCTCCAG AGGGCATCCC CTCCCCATGC ATGTCTCCAT ATTCCCACCC CCATGGGAGT 
GTGGCTGGCT TCATGGGGGT GCCAGCCCCT TCTGCGGCTC ACCCTGGCAT CTACTCCATC 
CATGGCTTTC CCCCCACCCT GGGGGGCCAC AGCTTTGAGC CTTCCTCAGA TGGTGACTAT 
AAGTCTCCAA GCCTCGTCTC GCTCAGGGTA AAGCCCAAGG AGCCACCCGG CCTTCTGAAC 
TGGACCACGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Exome sequencing revealed a novel nonsense variant in ALX3 gene underlying frontorhiny.
Journal of human genetics63(1)97-100(2018 Jan)
Ullah A,Umair M,E-Kalsoom U,Shahzad S,Basit S,Ahmad W

An atlas of genetic influences on human blood metabolites.
Nature genetics46(6)543-550(2014 Jun)
Shin SY,Fauman EB,Petersen AK,Krumsiek J,Santos R,Huang J,Arnold M,Erte I,Forgetta V,Yang TP,Walter K,Menni C,Chen L,Vasquez L,Valdes AM,Hyde CL,Wang V,Ziemek D,Roberts P,Xi L,Grundberg E,,Waldenberger M,Richards JB,Mohney RP,Milburn MV,John SL,Trimmer J,Theis FJ,Overington JP,Suhre K,Brosnan MJ,Gieger C,Kastenm?ller G,Spector TD,Soranzo N

Exclusion of mutations in TGIF, ALX3, and ALX4 genes in patients with the syndrome of frontonasal dysgenesis, callosal agenesis, basal encephalocele, and eye anomalies.
American journal of medical genetics. Part A158A(5)1233-5(2012 May)
Ribeiro-Bicudo LA,Quiezi RG,Guion-Almeida ML,Legnaro C,Richieri-Costa A

Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
PLoS genetics8(5)e1002695(2012)
Fox CS,Liu Y,White CC,Feitosa M,Smith AV,Heard-Costa N,Lohman K,,,,Johnson AD,Foster MC,Greenawalt DM,Griffin P,Ding J,Newman AB,Tylavsky F,Miljkovic I,Kritchevsky SB,Launer L,Garcia M,Eiriksdottir G,Carr JJ,Gudnason V,Harris TB,Cupples LA,Borecki IB

Clinical and genetic characterization of frontorhiny: report of 3 novel cases and discussion of the surgical management.
Archives of facial plastic surgery13(6)415-20(2011 Nov-Dec)
Pham NS,Rafii A,Liu J,Boyadjiev SA,Tollefson TT