CALHM1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	CALHM1
Entrez Gene ID	255022
Full Name	calcium homeostasis modulator 1
Synonyms	FAM26C
General protein information	Preferred Names calcium homeostasis modulator 1 Names calcium homeostasis modulator protein 1 family with sequence similarity 26, member C
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 10 Map Location: 10q24.33
Summary	This gene encodes a calcium channel that plays a role in processing of amyloid-beta precursor protein. A polymorphism at this locus has been reported to be associated with susceptibility to late-onset Alzheimer's disease in some populations, but the pathogenicity of this polymorphism is unclear.[provided by RefSeq, Mar 2010].
Disorder MIM:	612234

mRNA and Protein(s)

mRNA	Protein	Name
NM_001001412.3	NP_001001412.3	calcium homeostasis modulator protein 1
NM_001001412.4	NP_001001412.3	calcium homeostasis modulator protein 1

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Calhm1	NP_001074740.1
Gallus gallus (chicken)	CALHM1	XP_426534.2
Danio rerio (zebrafish)	calhm1	XP_001344294.1
Danio rerio (zebrafish)	LOC101887127	XP_005160176.1
Bos taurus (cattle)	CALHM1	XP_002698508.1
Xenopus tropicalis (tropical clawed frog)	calhm1	XP_004916529.1
Homo sapiens (human)	CALHM1	NP_001001412.3
	LOC714766	XP_001113863.1
Rattus norvegicus (Norway rat)	Calhm1	NP_001102638.1
Xenopus tropicalis (tropical clawed frog)	LOC100489360	XP_002936848.1
Pan troglodytes (chimpanzee)	CALHM1	XP_521596.2
Canis lupus familiaris (dog)	CALHM1	XP_003640029.1

Gene Ontology
Bibliography

Related articles in PubMed

Blockade and knock-out of CALHM1 channels attenuate ischemic brain damage.
Cisneros-Mejorado A, Gottlieb M, Ruiz A, Chara JC, P?rez-Samart?n A, Marambaud P, Matute C
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism271678X17713587(2017 Jan)

Genetic association of CALHM1 rs2986017 polymorphism with risk of Alzheimer's disease: a meta-analysis.
Lu Y, Liu W, Tan K, Peng J, Zhu Y, Wang X
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology37(4)525-32(2016 Apr)

Calcium homeostasis modulator 1 gene P86L polymorphism and the risk for alzheimer's disease: A meta-analysis.
Mun MJ, Kim JH, Choi JY, Jang WC
Neuroscience letters6198-14(2016 Apr)

CALHM1 and its polymorphism P86L differentially control Ca??homeostasis, mitogen-activated protein kinase signaling, and cell vulnerability upon exposure to amyloid ?.
Moreno-Ortega AJ, Buendia I, Mouhid L, Egea J, Lucea S, Ruiz-Nu?o A, L?pez MG, Cano-Abad MF
Aging cell14(6)1094-102(2015 Dec)

No association between CALHM1 and risk for Alzheimer dementia in a Belgian population.
Sleegers K, Brouwers N, Bettens K, Engelborghs S, van Miegroet H, De Deyn PP, Van Broeckhoven C
Human mutation30(4)E570-4(2009 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Meta-analysis suggested that CALHM1 rs2986017 might be associated with increased Alzheimer's disease risk in Caucasian, but not Asian population
Title: Genetic association of CALHM1 rs2986017 polymorphism with risk of Alzheimer's disease: a meta-analysis.

CALHM1 polymorphism may be potential biomarker in patients with Alzheimer disease. [meta-analysis]
Title: Calcium homeostasis modulator 1 gene P86L polymorphism and the risk for alzheimer's disease: A meta-analysis.

In the presence of antibody, P86L-CALHM1 shifts the balance between neurodegeneration and neuronal survival toward the stimulation of pro-cytotoxic pathways, thus potentially contributing to its deleterious effects in Alzheimer's disease.
Title: CALHM1 and its polymorphism P86L differentially control Ca??homeostasis, mitogen-activated protein kinase signaling, and cell vulnerability upon exposure to amyloid ?.

CALHM1 p.P86L variation may not be an AD susceptibility factor in the Han Chinese population.
Title: Lack of association between CALHM1 p.P86L variation and Alzheimer's disease in the Han Chinese population.

The rare R154H variant interferes with CALHM1 control of cytosolic Ca2+ and Abeta accumulation.
Title: Effect of the CALHM1 G330D and R154H human variants on the control of cytosolic Ca2+ and A? levels.

The following CALHM1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CALHM1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu24383	NM_001001412.4 Latest version!	Homo sapiens calcium homeostasis modulator 1 (CALHM1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00
View Old Accession Versions >>
OHu24383	NM_001001412.3	Homo sapiens calcium homeostasis modulator 1 (CALHM1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$265.30 $379.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CALHM1 ( NM_001001412.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_001001412.3 Homo sapiens calcium homeostasis modulator 1 (CALHM1), mRNA.

Price & Availability↑

CloneID	OHu24383
Clone ID Related Accession (Same CDS sequence)	NM_001001412.3 , NM_001001412.4
Accession Version	NM_001001412.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1041bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-05-03
Organism	Homo sapiens(human)
Product	calcium homeostasis modulator protein 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL139339.22. This sequence is a reference standard in the RefSeqGene project. On Jul 25, 2008 this sequence version replaced NM_001001412.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC036193.1, SRR1660807.150772.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2142348, SAMEA2145743 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##

ATGATGGACA AGTTCCGGAT GATCTTCCAG TTCCTGCAGT CCAACCAGGA GTCCTTCATG 
AATGGCATCT GTGGCATCAT GGCCCTGGCC AGTGCCCAGA TGTACTCGGC CTTCGACTTC 
AACTGCCCCT GCCTGCCGGG CTACAATGCA GCCTACAGCG CGGGCATCCT GCTGGCGCCA 
CCCCTGGTGC TCTTTCTGCT TGGCCTGGTC ATGAACAACA ACGTGTCCAT GCTGGCCGAA 
GAGTGGAAGC GGCCGCTGGG CCGCCGGGCC AAGGACCCCG CTGTGTTGCG CTACATGTTC 
TGCTCCATGG CCCAGCGCGC CCTCATCGCG CCTGTCGTCT GGGTGGCCGT CACGCTACTC 
GACGGCAAAT GCTTCCTCTG TGCCTTCTGC ACTGCCGTGC CCGTGAGCGC ACTGGGCAAC 
GGCAGCCTGG CACCCGGCCT TCCTGCCCCC GAGCTCGCCC GCCTGCTGGC CCGGGTGCCC 
TGCCCTGAGA TCTACGATGG CGACTGGCTG TTGGCCCGAG AGGTGGCCGT GCGTTACCTC 
CGCTGCATCT CCCAGGCGCT GGGCTGGTCC TTCGTGCTGC TGACCACTCT GCTGGCATTC 
GTGGTGCGCT CTGTGCGGCC CTGCTTCACG CAGGCCGCCT TCCTCAAGAG CAAGTACTGG 
TCCCACTATA TCGACATCGA GCGCAAGCTC TTCGACGAGA CGTGCACGGA GCACGCCAAA 
GCCTTTGCCA AGGTCTGCAT CCAGCAGTTC TTCGAGGCCA TGAACCATGA CCTGGAGCTG 
GGTCACACCC ACGGGACACT GGCCACGGCC CCTGCTTCCG CAGCTGCCCC CACGACCCCC 
GATGGTGCGG AGGAGGAAAG GGAGAAGCTG CGTGGCATCA CGGATCAAGG CACCATGAAC 
AGGCTGCTCA CGAGCTGGCA CAAATGCAAA CCGCCTCTGC GGCTGGGCCA GGAGGAGCCA 
CCGCTGATGG GCAACGGCTG GGCTGGGGGT GGGCCCCGGC CTCCGCGTAA GGAGGTGGCC 
ACCTACTTCA GCAAAGTGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001001412.3
CDS	141..1181
Translation	MMDKFRMIFQFLQSNQESFMNGICGIMALASAQMYSAFDFNCPCLPGYNAAYSAGILLAPPLVLFLLGLVMNNNVSMLAEEWKRPLGRRAKDPAVLRYMFCSMAQRALIAPVVWVAVTLLDGKCFLCAFCTAVPVSALGNGSLAPGLPAPELARLLARVPCPEIYDGDWLLAREVAVRYLRCISQALGWSFVLLTTLLAFVVRSVRPCFTQAAFLKSKYWSHYIDIERKLFDETCTEHAKAFAKVCIQQFFEAMNHDLELGHTHGTLATAPASAAAPTTPDGAEEEREKLRGITDQGTMNRLLTSWHKCKPPLRLGQEEPPLMGNGWAGGGPRPPRKEVATYFSKV

Target ORF information:

RefSeq Version	NM_001001412.3
Organism	Homo sapiens(human)
Definition	Homo sapiens calcium homeostasis modulator 1 (CALHM1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001001412.3

ORF Insert Sequence:

ATGATGGACA AGTTCCGGAT GATCTTCCAG TTCCTGCAGT CCAACCAGGA GTCCTTCATG 
AATGGCATCT GTGGCATCAT GGCCCTGGCC AGTGCCCAGA TGTACTCGGC CTTCGACTTC 
AACTGCCCCT GCCTGCCGGG CTACAATGCA GCCTACAGCG CGGGCATCCT GCTGGCGCCA 
CCCCTGGTGC TCTTTCTGCT TGGCCTGGTC ATGAACAACA ACGTGTCCAT GCTGGCCGAA 
GAGTGGAAGC GGCCGCTGGG CCGCCGGGCC AAGGACCCCG CTGTGTTGCG CTACATGTTC 
TGCTCCATGG CCCAGCGCGC CCTCATCGCG CCTGTCGTCT GGGTGGCCGT CACGCTACTC 
GACGGCAAAT GCTTCCTCTG TGCCTTCTGC ACTGCCGTGC CCGTGAGCGC ACTGGGCAAC 
GGCAGCCTGG CACCCGGCCT TCCTGCCCCC GAGCTCGCCC GCCTGCTGGC CCGGGTGCCC 
TGCCCTGAGA TCTACGATGG CGACTGGCTG TTGGCCCGAG AGGTGGCCGT GCGTTACCTC 
CGCTGCATCT CCCAGGCGCT GGGCTGGTCC TTCGTGCTGC TGACCACTCT GCTGGCATTC 
GTGGTGCGCT CTGTGCGGCC CTGCTTCACG CAGGCCGCCT TCCTCAAGAG CAAGTACTGG 
TCCCACTATA TCGACATCGA GCGCAAGCTC TTCGACGAGA CGTGCACGGA GCACGCCAAA 
GCCTTTGCCA AGGTCTGCAT CCAGCAGTTC TTCGAGGCCA TGAACCATGA CCTGGAGCTG 
GGTCACACCC ACGGGACACT GGCCACGGCC CCTGCTTCCG CAGCTGCCCC CACGACCCCC 
GATGGTGCGG AGGAGGAAAG GGAGAAGCTG CGTGGCATCA CGGATCAAGG CACCATGAAC 
AGGCTGCTCA CGAGCTGGCA CAAATGCAAA CCGCCTCTGC GGCTGGGCCA GGAGGAGCCA 
CCGCTGATGG GCAACGGCTG GGCTGGGGGT GGGCCCCGGC CTCCGCGTAA GGAGGTGGCC 
ACCTACTTCA GCAAAGTGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CALHM1 ( NM_001001412.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_001001412.3 Homo sapiens calcium homeostasis modulator 1 (CALHM1), mRNA.

Price & Availability↑

CloneID	OHu24383
Clone ID Related Accession (Same CDS sequence)	NM_001001412.3 , NM_001001412.4
Accession Version	NM_001001412.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1041bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-19
Organism	Homo sapiens(human)
Product	calcium homeostasis modulator protein 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL139339.22. On Nov 27, 2019 this sequence version replaced NM_001001412.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC036208.1, SRR1803616.270283.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGATGGACA AGTTCCGGAT GATCTTCCAG TTCCTGCAGT CCAACCAGGA GTCCTTCATG 
AATGGCATCT GTGGCATCAT GGCCCTGGCC AGTGCCCAGA TGTACTCGGC CTTCGACTTC 
AACTGCCCCT GCCTGCCGGG CTACAATGCA GCCTACAGCG CGGGCATCCT GCTGGCGCCA 
CCCCTGGTGC TCTTTCTGCT TGGCCTGGTC ATGAACAACA ACGTGTCCAT GCTGGCCGAA 
GAGTGGAAGC GGCCGCTGGG CCGCCGGGCC AAGGACCCCG CTGTGTTGCG CTACATGTTC 
TGCTCCATGG CCCAGCGCGC CCTCATCGCG CCTGTCGTCT GGGTGGCCGT CACGCTACTC 
GACGGCAAAT GCTTCCTCTG TGCCTTCTGC ACTGCCGTGC CCGTGAGCGC ACTGGGCAAC 
GGCAGCCTGG CACCCGGCCT TCCTGCCCCC GAGCTCGCCC GCCTGCTGGC CCGGGTGCCC 
TGCCCTGAGA TCTACGATGG CGACTGGCTG TTGGCCCGAG AGGTGGCCGT GCGTTACCTC 
CGCTGCATCT CCCAGGCGCT GGGCTGGTCC TTCGTGCTGC TGACCACTCT GCTGGCATTC 
GTGGTGCGCT CTGTGCGGCC CTGCTTCACG CAGGCCGCCT TCCTCAAGAG CAAGTACTGG 
TCCCACTATA TCGACATCGA GCGCAAGCTC TTCGACGAGA CGTGCACGGA GCACGCCAAA 
GCCTTTGCCA AGGTCTGCAT CCAGCAGTTC TTCGAGGCCA TGAACCATGA CCTGGAGCTG 
GGTCACACCC ACGGGACACT GGCCACGGCC CCTGCTTCCG CAGCTGCCCC CACGACCCCC 
GATGGTGCGG AGGAGGAAAG GGAGAAGCTG CGTGGCATCA CGGATCAAGG CACCATGAAC 
AGGCTGCTCA CGAGCTGGCA CAAATGCAAA CCGCCTCTGC GGCTGGGCCA GGAGGAGCCA 
CCGCTGATGG GCAACGGCTG GGCTGGGGGT GGGCCCCGGC CTCCGCGTAA GGAGGTGGCC 
ACCTACTTCA GCAAAGTGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001001412.3
CDS	150..1190
Translation	MMDKFRMIFQFLQSNQESFMNGICGIMALASAQMYSAFDFNCPCLPGYNAAYSAGILLAPPLVLFLLGLVMNNNVSMLAEEWKRPLGRRAKDPAVLRYMFCSMAQRALIAPVVWVAVTLLDGKCFLCAFCTAVPVSALGNGSLAPGLPAPELARLLARVPCPEIYDGDWLLAREVAVRYLRCISQALGWSFVLLTTLLAFVVRSVRPCFTQAAFLKSKYWSHYIDIERKLFDETCTEHAKAFAKVCIQQFFEAMNHDLELGHTHGTLATAPASAAAPTTPDGAEEEREKLRGITDQGTMNRLLTSWHKCKPPLRLGQEEPPLMGNGWAGGGPRPPRKEVATYFSKV

Target ORF information:

RefSeq Version	NM_001001412.4
Organism	Homo sapiens(human)
Definition	Homo sapiens calcium homeostasis modulator 1 (CALHM1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001001412.4

ORF Insert Sequence:

ATGATGGACA AGTTCCGGAT GATCTTCCAG TTCCTGCAGT CCAACCAGGA GTCCTTCATG 
AATGGCATCT GTGGCATCAT GGCCCTGGCC AGTGCCCAGA TGTACTCGGC CTTCGACTTC 
AACTGCCCCT GCCTGCCGGG CTACAATGCA GCCTACAGCG CGGGCATCCT GCTGGCGCCA 
CCCCTGGTGC TCTTTCTGCT TGGCCTGGTC ATGAACAACA ACGTGTCCAT GCTGGCCGAA 
GAGTGGAAGC GGCCGCTGGG CCGCCGGGCC AAGGACCCCG CTGTGTTGCG CTACATGTTC 
TGCTCCATGG CCCAGCGCGC CCTCATCGCG CCTGTCGTCT GGGTGGCCGT CACGCTACTC 
GACGGCAAAT GCTTCCTCTG TGCCTTCTGC ACTGCCGTGC CCGTGAGCGC ACTGGGCAAC 
GGCAGCCTGG CACCCGGCCT TCCTGCCCCC GAGCTCGCCC GCCTGCTGGC CCGGGTGCCC 
TGCCCTGAGA TCTACGATGG CGACTGGCTG TTGGCCCGAG AGGTGGCCGT GCGTTACCTC 
CGCTGCATCT CCCAGGCGCT GGGCTGGTCC TTCGTGCTGC TGACCACTCT GCTGGCATTC 
GTGGTGCGCT CTGTGCGGCC CTGCTTCACG CAGGCCGCCT TCCTCAAGAG CAAGTACTGG 
TCCCACTATA TCGACATCGA GCGCAAGCTC TTCGACGAGA CGTGCACGGA GCACGCCAAA 
GCCTTTGCCA AGGTCTGCAT CCAGCAGTTC TTCGAGGCCA TGAACCATGA CCTGGAGCTG 
GGTCACACCC ACGGGACACT GGCCACGGCC CCTGCTTCCG CAGCTGCCCC CACGACCCCC 
GATGGTGCGG AGGAGGAAAG GGAGAAGCTG CGTGGCATCA CGGATCAAGG CACCATGAAC 
AGGCTGCTCA CGAGCTGGCA CAAATGCAAA CCGCCTCTGC GGCTGGGCCA GGAGGAGCCA 
CCGCTGATGG GCAACGGCTG GGCTGGGGGT GGGCCCCGGC CTCCGCGTAA GGAGGTGGCC 
ACCTACTTCA GCAAAGTGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Blockade and knock-out of CALHM1 channels attenuate ischemic brain damage.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism271678X17713587(2017 Jan)
Cisneros-Mejorado A,Gottlieb M,Ruiz A,Chara JC,P?rez-Samart?n A,Marambaud P,Matute C

Genetic association of CALHM1 rs2986017 polymorphism with risk of Alzheimer's disease: a meta-analysis.
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology37(4)525-32(2016 Apr)
Lu Y,Liu W,Tan K,Peng J,Zhu Y,Wang X

Calcium homeostasis modulator 1 gene P86L polymorphism and the risk for alzheimer's disease: A meta-analysis.
Neuroscience letters6198-14(2016 Apr)
Mun MJ,Kim JH,Choi JY,Jang WC

CALHM1 and its polymorphism P86L differentially control Ca??homeostasis, mitogen-activated protein kinase signaling, and cell vulnerability upon exposure to amyloid ?.
Aging cell14(6)1094-102(2015 Dec)
Moreno-Ortega AJ,Buendia I,Mouhid L,Egea J,Lucea S,Ruiz-Nu?o A,L?pez MG,Cano-Abad MF

No association between CALHM1 and risk for Alzheimer dementia in a Belgian population.
Human mutation30(4)E570-4(2009 Apr)
Sleegers K,Brouwers N,Bettens K,Engelborghs S,van Miegroet H,De Deyn PP,Van Broeckhoven C