DEFB107A cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	DEFB107A
Entrez Gene ID	245910
Full Name	defensin beta 107A
Synonyms	BD-7,DEFB-7,DEFB107
General protein information	Preferred Names defensin beta 107A Names beta-defensin 107 beta-defensin 7 defensin, beta 7
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 8 Map Location: 8p23.1
Summary	Defensins form a family of antimicrobial and cytotoxic peptides made by neutrophils. Defensins are short, processed peptide molecules that are classified by structure into three groups: alpha-defensins, beta-defensins and theta-defensins. All beta-defensin genes are densely clustered in four to five syntenic chromosomal regions. Chromosome 8p23 contains at least two copies of the duplicated beta-defensin cluster. This duplication results in two identical copies of defensin, beta 107, DEFB107A and DEFB107B, in tail-to-tail orientation. This gene, DEFB107A, represents the more centromeric copy. [provided by RefSeq, Oct 2014].

mRNA and Protein(s)

mRNA	Protein	Name
NM_001037668.1	NP_001032757.2	beta-defensin 107 precursor

Pathways from BioSystems

Homologies

Homo sapiens (human)	DEFB107A	NP_001032757.2
Homo sapiens (human)	DEFB107B	NP_001035795.1

Gene Ontology
Bibliography

Related articles in PubMed

Narrowing down the distal border of the copy number variable beta-defensin gene cluster on human 8p23.
Taudien S, Huse K, Groth M, Platzer M
BMC research notes793(2014 Feb)

Copy number variation of the beta defensin gene cluster on chromosome 8p influences the bacterial microbiota within the nasopharynx of otitis-prone children.
Jones EA, Kananurak A, Bevins CL, Hollox EJ, Bakaletz LO
PloS one9(5)e98269(2014)

Cross-species analysis of the mammalian beta-defensin gene family: presence of syntenic gene clusters and preferential expression in the male reproductive tract.
Patil AA, Cai Y, Sang Y, Blecha F, Zhang G
Physiological genomics23(1)5-17(2005 Sep)

Polymorphic segmental duplications at 8p23.1 challenge the determination of individual defensin gene repertoires and the assembly of a contiguous human reference sequence.
Taudien S, Galgoczy P, Huse K, Reichwald K, Schilhabel M, Szafranski K, Shimizu A, Asakawa S, Frankish A, Loncarevic IF, Shimizu N, Siddiqui R, Platzer M
BMC genomics5(1)92(2004 Dec)

Evidence for duplication of the human defensin gene DEFB4 in chromosomal region 8p22-23 and implications for the analysis of SNP allele distribution.
Boniotto M, Ventura M, Eskdale J, Crovella S, Gallagher G
Genetic testing8(3)325-7(2004)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data indicate the copy number variation (CNV) of beta-defensin gene cluster for six indels between ~1 kb distal of DEFB108P and 10 kb proximal of DEFB107.
Title: Narrowing down the distal border of the copy number variable beta-defensin gene cluster on human 8p23.

This protein is thought to have antimicrobial activity.
Title: Cross-species analysis of the mammalian beta-defensin gene family: presence of syntenic gene clusters and preferential expression in the male reproductive tract.

The following DEFB107A gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the DEFB107A cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu30204	NM_001037668.1 Latest version!	Homo sapiens defensin beta 107A (DEFB107A), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

DEFB107A ( NM_001037668.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001032757.2 Homo sapiens defensin beta 107A (DEFB107A), mRNA.

Price & Availability↑

CloneID	OHu30204
Clone ID Related Accession (Same CDS sequence)	NM_001037668.1
Accession Version	NM_001037668.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 213bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-06-29
Organism	Homo sapiens(human)
Product	beta-defensin 107 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DQ119826.1. ##Evidence-Data-START## Transcript exon combination :: DQ119826.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000335021.2/ ENSP00000334681.2 Protein has antimicrobial activity :: PMID: 16033865 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##

ATGCCTGGAG CCATGAAAAT ATTTGTCTTT ATTTTGGCTG CTCTCATTCT TCTTGCTCAA 
ATTTTCCAAG CCAGGACAGC AATTCATAGA GCACTAATTA GTAAGAGAAT GGAAGGTCAC 
TGTGAAGCCG AATGTCTTAC CTTTGAAGTA AAGATTGGGG GCTGTAGAGC TGAATTAGCA 
CCATTTTGCT GCAAAAACAG AAAGAAACAT TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001032757.2
CDS	89..301
Translation	MPGAMKIFVFILAALILLAQIFQARTAIHRALISKRMEGHCEAECLTFEVKIGGCRAELAPFCCKNRKKH

Target ORF information:

RefSeq Version	NM_001037668.1
Organism	Homo sapiens(human)
Definition	Homo sapiens defensin beta 107A (DEFB107A), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001037668.1

ORF Insert Sequence:

ATGCCTGGAG CCATGAAAAT ATTTGTCTTT ATTTTGGCTG CTCTCATTCT TCTTGCTCAA 
ATTTTCCAAG CCAGGACAGC AATTCATAGA GCACTAATTA GTAAGAGAAT GGAAGGTCAC 
TGTGAAGCCG AATGTCTTAC CTTTGAAGTA AAGATTGGGG GCTGTAGAGC TGAATTAGCA 
CCATTTTGCT GCAAAAACAG AAAGAAACAT TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Narrowing down the distal border of the copy number variable beta-defensin gene cluster on human 8p23.
BMC research notes793(2014 Feb)
Taudien S,Huse K,Groth M,Platzer M

Copy number variation of the beta defensin gene cluster on chromosome 8p influences the bacterial microbiota within the nasopharynx of otitis-prone children.
PloS one9(5)e98269(2014)
Jones EA,Kananurak A,Bevins CL,Hollox EJ,Bakaletz LO

Cross-species analysis of the mammalian beta-defensin gene family: presence of syntenic gene clusters and preferential expression in the male reproductive tract.
Physiological genomics23(1)5-17(2005 Sep)
Patil AA,Cai Y,Sang Y,Blecha F,Zhang G

Polymorphic segmental duplications at 8p23.1 challenge the determination of individual defensin gene repertoires and the assembly of a contiguous human reference sequence.
BMC genomics5(1)92(2004 Dec)
Taudien S,Galgoczy P,Huse K,Reichwald K,Schilhabel M,Szafranski K,Shimizu A,Asakawa S,Frankish A,Loncarevic IF,Shimizu N,Siddiqui R,Platzer M

Evidence for duplication of the human defensin gene DEFB4 in chromosomal region 8p22-23 and implications for the analysis of SNP allele distribution.
Genetic testing8(3)325-7(2004)
Boniotto M,Ventura M,Eskdale J,Crovella S,Gallagher G