SLC16A8 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	SLC16A8
Entrez Gene ID	23539
Full Name	solute carrier family 16 member 8
Synonyms	MCT3,REMP
General protein information	Preferred Names solute carrier family 16 member 8 Names monocarboxylate transporter 3 MCT 3 solute carrier 16 (monocarboxylic acid transporters), member 8 solute carrier family 16 (monocarboxylate transporter), member 8 solute carrier family 16, member 8 (monocarboxylic acid transporter 3)
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 22 Map Location: 22q13.1
Summary	SLC16A8 is a member of a family of proton-coupled monocarboxylate transporters that mediate lactate transport across cell membranes (Yoon et al., 1999 [PubMed 10493836]).[supplied by OMIM, Apr 2010].
Disorder MIM:	610409

mRNA and Protein(s)

mRNA	Protein	Name
NM_013356.2	NP_037488.2	monocarboxylate transporter 3
NM_013356.3	NP_037488.2	monocarboxylate transporter 3
XM_017028685.1	XP_016884174.1	monocarboxylate transporter 3 isoform X1

Pathways from BioSystems

Homologies

	SLC16A8	XP_001092182.1
Gallus gallus (chicken)	SLC16A8	NP_990471.1
Homo sapiens (human)	SLC16A8	NP_037488.2
Mus musculus (house mouse)	Slc16a8	NP_065262.1
Rattus norvegicus (Norway rat)	Slc16a8	NP_113932.2
Danio rerio (zebrafish)	LOC557884	XP_686130.1
Pan troglodytes (chimpanzee)	SLC16A8	XP_001163402.1
Canis lupus familiaris (dog)	SLC16A8	XP_852708.2
Bos taurus (cattle)	SLC16A8	XP_002687978.1

Gene Ontology
Bibliography

Related articles in PubMed

Serum Levels of TIMP-3, LIPC, IER3, and SLC16A8 in CFH-Negative AMD Cases.
Sharma K, Tyagi R, Singh R, Sharma SK, Anand A
Journal of cellular biochemistry118(8)2087-2095(2017 Aug)

Seven new loci associated with age-related macular degeneration.
Fritsche LG, Chen W, Schu M, Yaspan BL, Yu Y, Thorleifsson G, Zack DJ, Arakawa S, Cipriani V, Ripke S, Igo RP Jr, Buitendijk GH, Sim X, Weeks DE, Guymer RH, Merriam JE, Francis PJ, Hannum G, Agarwal A, Armbrecht AM, Audo I, Aung T, Barile GR, Benchaboune M, Bird AC, Bishop PN, Branham KE, Brooks M, Brucker AJ, Cade WH, Cain MS, Campochiaro PA, Chan CC, Cheng CY, Chew EY, Chin KA, Chowers I, Clayton DG, Cojocaru R, Conley YP, Cornes BK, Daly MJ, Dhillon B, Edwards AO, Evangelou E, Fagerness J, Ferreyra HA, Friedman JS, Geirsdottir A, George RJ, Gieger C, Gupta N, Hagstrom SA, Harding SP, Haritoglou C, Heckenlively JR, Holz FG, Hughes G, Ioannidis JP, Ishibashi T, Joseph P, Jun G, Kamatani Y, Katsanis N, N Keilhauer C, Khan JC, Kim IK, Kiyohara Y, Klein BE, Klein R, Kovach JL, Kozak I, Lee CJ, Lee KE, Lichtner P, Lotery AJ, Meitinger T, Mitchell P, Mohand-Sa?d S, Moore AT, Morgan DJ, Morrison MA, Myers CE, Naj AC, Nakamura Y, Okada Y, Orlin A, Ortube MC, Othman MI, Pappas C, Park KH, Pauer GJ, Peachey NS, Poch O, Priya RR, Reynolds R, Richardson AJ, Ripp R, Rudolph G, Ryu E, Sahel JA, Schaumberg DA, Scholl HP, Schwartz SG, Scott WK, Shahid H, Sigurdsson H, Silvestri G, Sivakumaran TA, Smith RT, Sobrin L, Souied EH, Stambolian DE, Stefansson H, Sturgill-Short GM, Takahashi A, Tosakulwong N, Truitt BJ, Tsironi EE, Uitterlinden AG, van Duijn CM, Vijaya L, Vingerling JR, Vithana EN, Webster AR, Wichmann HE, Winkler TW, Wong TY, Wright AF, Zelenika D, Zhang M, Zhao L, Zhang K, Klein ML, Hageman GS, Lathrop GM, Stefansson K, Allikmets R, Baird PN, Gorin MB, Wang JJ, Klaver CC, Seddon JM, Pericak-Vance MA, Iyengar SK, Yates JR, Swaroop A, Weber BH, Kubo M, Deangelis MM, L?veillard T, Thorsteinsdottir U, Haines JL, Farrer LA, Heid IM, Abecasis GR,
Nature genetics45(4)433-9, 439e1-2(2013 Apr)

L-type voltage-dependent calcium channel alpha subunit 1C is a novel candidate gene associated with secondary hyperparathyroidism: an application of haplotype-based analysis for multiple linked single nucleotide polymorphisms.
Yokoyama K, Urashima M, Ohkido I, Kono T, Yoshida T, Muramatsu M, Niu T, Hosoya T
Nephron. Clinical practice115(4)c237-43(2010)

Basigin (CD147) is the target for organomercurial inhibition of monocarboxylate transporter isoforms 1 and 4: the ancillary protein for the insensitive MCT2 is EMBIGIN (gp70).
Wilson MC, Meredith D, Fox JE, Manoharan C, Davies AJ, Halestrap AP
The Journal of biological chemistry280(29)27213-21(2005 Jul)

The SLC16 gene family-from monocarboxylate transporters (MCTs) to aromatic amino acid transporters and beyond.
Halestrap AP, Meredith D
Pflugers Archiv : European journal of physiology447(5)619-28(2004 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The expression level of LIPC, SLC16A8, and TIMP-3 was significantly associated with age-related macular degeneration pathology.
Title: Serum Levels of TIMP-3, LIPC, IER3, and SLC16A8 in CFH-Negative AMD Cases.

Observational study of gene-disease association. (HuGE Navigator)
Title: L-type voltage-dependent calcium channel alpha subunit 1C is a novel candidate gene associated with secondary hyperparathyroidism: an application of haplotype-based analysis for multiple linked single nucleotide polymorphisms.

The following SLC16A8 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SLC16A8 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu06468	NM_013356.3 Latest version!	Homo sapiens solute carrier family 16 member 8 (SLC16A8), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$219.50-$307.30 $439.00
OHu06468	XM_017028685.1 Latest version!	Homo sapiens solute carrier family 16 member 8 (SLC16A8), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$219.50-$307.30 $439.00
View Old Accession Versions >>
OHu06468	NM_013356.2	Homo sapiens solute carrier family 16 member 8 (SLC16A8), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$219.50-$307.30 $439.00
Hide Old Accession Versions >>

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***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

SLC16A8 ( NM_013356.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_037488.2 Homo sapiens solute carrier family 16 member 8 (SLC16A8), mRNA.

Price & Availability↑

CloneID	OHu06468
Clone ID Related Accession (Same CDS sequence)	NM_013356.2 , NM_013356.3 , XM_017028685.1
Accession Version	NM_013356.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1515bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-05-03
Organism	Homo sapiens(human)
Product	monocarboxylate transporter 3
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BM709138.1, AF132610.1, BM714896.1 and BM714916.1. On Sep 19, 2006 this sequence version replaced NM_013356.1. ##Evidence-Data-START## Transcript exon combination :: AF132610.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA2144333, SAMEA2145245 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END##

ATGGGCGCTG GCGGCCCCCG GCGGGGCGAG GGCCCCCCAG ACGGCGGCTG GGGCTGGGTG 
GTGCTGGGCG CCTGCTTTGT GGTCACCGGC TTCGCCTACG GCTTCCCCAA AGCCGTGAGC 
GTCTTCTTCC GCGCGCTCAT GCGCGACTTC GACGCCGGCT ACAGCGACAC GGCCTGGGTG 
TCCTCCATCA TGCTAGCCAT GCTCTACGGC ACGGGCCCCG TGTCCAGCAT CCTCGTGACC 
CGCTTTGGCT GTCGCCCGGT GATGCTGGCG GGTGGGCTGC TGGCTTCCGC GGGCATGATC 
CTAGCTTCCT TTGCCACGCG CCTCCTGGAG CTCTACCTGA CCGCTGGGGT GCTCACAGGC 
CTGGGCCTGG CCCTCAACTT CCAGCCGTCG CTCATCATGC TGGGGCTGTA CTTCGAGCGG 
CGGCGGCCTC TGGCCAACGG GCTGGCGGCG GCGGGCAGCC CCGTGTTCCT GTCCGCGCTG 
TCGCCGCTCG GCCAGCAGCT GCTGGAGCGC TTCGGCTGGC GCGGCGGCTT CCTGCTGCTC 
GGCGGGCTCC TGCTGCACTG CTGCGCCTGC GGGGCTGTCA TGAGGCCGCC GCCCGGGCCG 
GGCCCGCGAC CGCGCAGGGA CAGCGCCGGC GACCGCGCCG GGGACGCTCC GGGCGAGGCG 
GAGGCTGACG GTGCGGGGCT GCAGCTGCGC GAGGCATCCC CCAGGGTCCG GCCCCGCCGG 
CGCCTGCTGG ACTTGGCAGT GTGCACCGAC CGCGCCTTCG CCGTGTACGC CGTCACCAAG 
TTCCTGATGG CGCTCGGGCT CTTCGTCCCC GCCATCCTGC TGGTGAACTA CGCCAAGGAC 
GCGGGCGTGC CCGACACCGA CGCCGCCTTC CTGCTGTCCA TCGTGGGCTT CGTGGACATC 
GTGGCGCGCC CGGCGTGCGG CGCCCTGGCG GGCCTGGCGC GTCTGCGGCC GCACGTCCCG 
TATCTGTTCA GCCTGGCCCT GCTGGCCAAT GGGCTCACAG ACCTGAGCAG CGCACGCGCG 
CGCTCCTACG GCGCCCTCGT CGCCTTCTGC GTCGCCTTCG GCCTCTCCTA CGGCATGGTG 
GGCGCGCTGC AGTTCGAGGT GCTCATGGCG GCTGTGGGCG CGCCCCGCTT CCCCAGTGCG 
CTGGGCCTGG TGTTGCTCGT GGAGGCCGCG GCTGTGCTCA TCGGACCGCC CTCTGCCGGC 
CGCCTGGTGG ATGTGTTGAA GAACTATGAG ATCATCTTCT ACCTGGCCGG CTCTGAGGTG 
GCCCTGGCTG GGGTCTTCAT GGCTGTCGCC ACCAACTGCT GCCTGCGTTG TGCTAAAGCT 
GCCCCGTCAG GCCCAGGCAC TGAGGGCGGA GCCAGTGACA CTGAGGACGC TGAGGCTGAA 
GGGGACTCTG AGCCCCTGCC TGTTGTTGCA GAGGAACCCG GCAACCTGGA GGCCCTGGAG 
GTGCTCAGCG CCCGGGGCGA GCCCACAGAA CCAGAAATAG AGGCGAGGCC GAGGCTGGCT 
GCCGAGTCTG TATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_037488.2
CDS	131..1645
Translation	MGAGGPRRGEGPPDGGWGWVVLGACFVVTGFAYGFPKAVSVFFRALMRDFDAGYSDTAWVSSIMLAMLYGTGPVSSILVTRFGCRPVMLAGGLLASAGMILASFATRLLELYLTAGVLTGLGLALNFQPSLIMLGLYFERRRPLANGLAAAGSPVFLSALSPLGQQLLERFGWRGGFLLLGGLLLHCCACGAVMRPPPGPGPRPRRDSAGDRAGDAPGEAEADGAGLQLREASPRVRPRRRLLDLAVCTDRAFAVYAVTKFLMALGLFVPAILLVNYAKDAGVPDTDAAFLLSIVGFVDIVARPACGALAGLARLRPHVPYLFSLALLANGLTDLSSARARSYGALVAFCVAFGLSYGMVGALQFEVLMAAVGAPRFPSALGLVLLVEAAAVLIGPPSAGRLVDVLKNYEIIFYLAGSEVALAGVFMAVATNCCLRCAKAAPSGPGTEGGASDTEDAEAEGDSEPLPVVAEEPGNLEALEVLSARGEPTEPEIEARPRLAAESV

Target ORF information:

RefSeq Version	NM_013356.2
Organism	Homo sapiens(human)
Definition	Homo sapiens solute carrier family 16 member 8 (SLC16A8), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_013356.2

ORF Insert Sequence:

ATGGGCGCTG GCGGCCCCCG GCGGGGCGAG GGCCCCCCAG ACGGCGGCTG GGGCTGGGTG 
GTGCTGGGCG CCTGCTTTGT GGTCACCGGC TTCGCCTACG GCTTCCCCAA AGCCGTGAGC 
GTCTTCTTCC GCGCGCTCAT GCGCGACTTC GACGCCGGCT ACAGCGACAC GGCCTGGGTG 
TCCTCCATCA TGCTAGCCAT GCTCTACGGC ACGGGCCCCG TGTCCAGCAT CCTCGTGACC 
CGCTTTGGCT GTCGCCCGGT GATGCTGGCG GGTGGGCTGC TGGCTTCCGC GGGCATGATC 
CTAGCTTCCT TTGCCACGCG CCTCCTGGAG CTCTACCTGA CCGCTGGGGT GCTCACAGGC 
CTGGGCCTGG CCCTCAACTT CCAGCCGTCG CTCATCATGC TGGGGCTGTA CTTCGAGCGG 
CGGCGGCCTC TGGCCAACGG GCTGGCGGCG GCGGGCAGCC CCGTGTTCCT GTCCGCGCTG 
TCGCCGCTCG GCCAGCAGCT GCTGGAGCGC TTCGGCTGGC GCGGCGGCTT CCTGCTGCTC 
GGCGGGCTCC TGCTGCACTG CTGCGCCTGC GGGGCTGTCA TGAGGCCGCC GCCCGGGCCG 
GGCCCGCGAC CGCGCAGGGA CAGCGCCGGC GACCGCGCCG GGGACGCTCC GGGCGAGGCG 
GAGGCTGACG GTGCGGGGCT GCAGCTGCGC GAGGCATCCC CCAGGGTCCG GCCCCGCCGG 
CGCCTGCTGG ACTTGGCAGT GTGCACCGAC CGCGCCTTCG CCGTGTACGC CGTCACCAAG 
TTCCTGATGG CGCTCGGGCT CTTCGTCCCC GCCATCCTGC TGGTGAACTA CGCCAAGGAC 
GCGGGCGTGC CCGACACCGA CGCCGCCTTC CTGCTGTCCA TCGTGGGCTT CGTGGACATC 
GTGGCGCGCC CGGCGTGCGG CGCCCTGGCG GGCCTGGCGC GTCTGCGGCC GCACGTCCCG 
TATCTGTTCA GCCTGGCCCT GCTGGCCAAT GGGCTCACAG ACCTGAGCAG CGCACGCGCG 
CGCTCCTACG GCGCCCTCGT CGCCTTCTGC GTCGCCTTCG GCCTCTCCTA CGGCATGGTG 
GGCGCGCTGC AGTTCGAGGT GCTCATGGCG GCTGTGGGCG CGCCCCGCTT CCCCAGTGCG 
CTGGGCCTGG TGTTGCTCGT GGAGGCCGCG GCTGTGCTCA TCGGACCGCC CTCTGCCGGC 
CGCCTGGTGG ATGTGTTGAA GAACTATGAG ATCATCTTCT ACCTGGCCGG CTCTGAGGTG 
GCCCTGGCTG GGGTCTTCAT GGCTGTCGCC ACCAACTGCT GCCTGCGTTG TGCTAAAGCT 
GCCCCGTCAG GCCCAGGCAC TGAGGGCGGA GCCAGTGACA CTGAGGACGC TGAGGCTGAA 
GGGGACTCTG AGCCCCTGCC TGTTGTTGCA GAGGAACCCG GCAACCTGGA GGCCCTGGAG 
GTGCTCAGCG CCCGGGGCGA GCCCACAGAA CCAGAAATAG AGGCGAGGCC GAGGCTGGCT 
GCCGAGTCTG TATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SLC16A8 ( NM_013356.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_037488.2 Homo sapiens solute carrier family 16 member 8 (SLC16A8), mRNA.

Price & Availability↑

CloneID	OHu06468
Clone ID Related Accession (Same CDS sequence)	NM_013356.2 , NM_013356.3 , XM_017028685.1
Accession Version	NM_013356.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1515bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-04
Organism	Homo sapiens(human)
Product	monocarboxylate transporter 3
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AL031587.3. On Nov 21, 2019 this sequence version replaced NM_013356.2. ##Evidence-Data-START## CDS exon combination :: AF132610.1 [ECO:0000331] ##Evidence-Data-END## ##RefSeq-Attributes-START## inferred exon combination :: based on alignments, homology RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END##

ATGGGCGCTG GCGGCCCCCG GCGGGGCGAG GGCCCCCCAG ACGGCGGCTG GGGCTGGGTG 
GTGCTGGGCG CCTGCTTTGT GGTCACCGGC TTCGCCTACG GCTTCCCCAA AGCCGTGAGC 
GTCTTCTTCC GCGCGCTCAT GCGCGACTTC GACGCCGGCT ACAGCGACAC GGCCTGGGTG 
TCCTCCATCA TGCTAGCCAT GCTCTACGGC ACGGGCCCCG TGTCCAGCAT CCTCGTGACC 
CGCTTTGGCT GTCGCCCGGT GATGCTGGCG GGTGGGCTGC TGGCTTCCGC GGGCATGATC 
CTAGCTTCCT TTGCCACGCG CCTCCTGGAG CTCTACCTGA CCGCTGGGGT GCTCACAGGC 
CTGGGCCTGG CCCTCAACTT CCAGCCGTCG CTCATCATGC TGGGGCTGTA CTTCGAGCGG 
CGGCGGCCTC TGGCCAACGG GCTGGCGGCG GCGGGCAGCC CCGTGTTCCT GTCCGCGCTG 
TCGCCGCTCG GCCAGCAGCT GCTGGAGCGC TTCGGCTGGC GCGGCGGCTT CCTGCTGCTC 
GGCGGGCTCC TGCTGCACTG CTGCGCCTGC GGGGCTGTCA TGAGGCCGCC GCCCGGGCCG 
GGCCCGCGAC CGCGCAGGGA CAGCGCCGGC GACCGCGCCG GGGACGCTCC GGGCGAGGCG 
GAGGCTGACG GTGCGGGGCT GCAGCTGCGC GAGGCATCCC CCAGGGTCCG GCCCCGCCGG 
CGCCTGCTGG ACTTGGCAGT GTGCACCGAC CGCGCCTTCG CCGTGTACGC CGTCACCAAG 
TTCCTGATGG CGCTCGGGCT CTTCGTCCCC GCCATCCTGC TGGTGAACTA CGCCAAGGAC 
GCGGGCGTGC CCGACACCGA CGCCGCCTTC CTGCTGTCCA TCGTGGGCTT CGTGGACATC 
GTGGCGCGCC CGGCGTGCGG CGCCCTGGCG GGCCTGGCGC GTCTGCGGCC GCACGTCCCG 
TATCTGTTCA GCCTGGCCCT GCTGGCCAAT GGGCTCACAG ACCTGAGCAG CGCACGCGCG 
CGCTCCTACG GCGCCCTCGT CGCCTTCTGC GTCGCCTTCG GCCTCTCCTA CGGCATGGTG 
GGCGCGCTGC AGTTCGAGGT GCTCATGGCG GCTGTGGGCG CGCCCCGCTT CCCCAGTGCG 
CTGGGCCTGG TGTTGCTCGT GGAGGCCGCG GCTGTGCTCA TCGGACCGCC CTCTGCCGGC 
CGCCTGGTGG ATGTGTTGAA GAACTATGAG ATCATCTTCT ACCTGGCCGG CTCTGAGGTG 
GCCCTGGCTG GGGTCTTCAT GGCTGTCGCC ACCAACTGCT GCCTGCGTTG TGCTAAAGCT 
GCCCCGTCAG GCCCAGGCAC TGAGGGCGGA GCCAGTGACA CTGAGGACGC TGAGGCTGAA 
GGGGACTCTG AGCCCCTGCC TGTTGTTGCA GAGGAACCCG GCAACCTGGA GGCCCTGGAG 
GTGCTCAGCG CCCGGGGCGA GCCCACAGAA CCAGAAATAG AGGCGAGGCC GAGGCTGGCT 
GCCGAGTCTG TATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_037488.2
CDS	526..2040
Translation	MGAGGPRRGEGPPDGGWGWVVLGACFVVTGFAYGFPKAVSVFFRALMRDFDAGYSDTAWVSSIMLAMLYGTGPVSSILVTRFGCRPVMLAGGLLASAGMILASFATRLLELYLTAGVLTGLGLALNFQPSLIMLGLYFERRRPLANGLAAAGSPVFLSALSPLGQQLLERFGWRGGFLLLGGLLLHCCACGAVMRPPPGPGPRPRRDSAGDRAGDAPGEAEADGAGLQLREASPRVRPRRRLLDLAVCTDRAFAVYAVTKFLMALGLFVPAILLVNYAKDAGVPDTDAAFLLSIVGFVDIVARPACGALAGLARLRPHVPYLFSLALLANGLTDLSSARARSYGALVAFCVAFGLSYGMVGALQFEVLMAAVGAPRFPSALGLVLLVEAAAVLIGPPSAGRLVDVLKNYEIIFYLAGSEVALAGVFMAVATNCCLRCAKAAPSGPGTEGGASDTEDAEAEGDSEPLPVVAEEPGNLEALEVLSARGEPTEPEIEARPRLAAESV

Target ORF information:

RefSeq Version	NM_013356.3
Organism	Homo sapiens(human)
Definition	Homo sapiens solute carrier family 16 member 8 (SLC16A8), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_013356.3

ORF Insert Sequence:

ATGGGCGCTG GCGGCCCCCG GCGGGGCGAG GGCCCCCCAG ACGGCGGCTG GGGCTGGGTG 
GTGCTGGGCG CCTGCTTTGT GGTCACCGGC TTCGCCTACG GCTTCCCCAA AGCCGTGAGC 
GTCTTCTTCC GCGCGCTCAT GCGCGACTTC GACGCCGGCT ACAGCGACAC GGCCTGGGTG 
TCCTCCATCA TGCTAGCCAT GCTCTACGGC ACGGGCCCCG TGTCCAGCAT CCTCGTGACC 
CGCTTTGGCT GTCGCCCGGT GATGCTGGCG GGTGGGCTGC TGGCTTCCGC GGGCATGATC 
CTAGCTTCCT TTGCCACGCG CCTCCTGGAG CTCTACCTGA CCGCTGGGGT GCTCACAGGC 
CTGGGCCTGG CCCTCAACTT CCAGCCGTCG CTCATCATGC TGGGGCTGTA CTTCGAGCGG 
CGGCGGCCTC TGGCCAACGG GCTGGCGGCG GCGGGCAGCC CCGTGTTCCT GTCCGCGCTG 
TCGCCGCTCG GCCAGCAGCT GCTGGAGCGC TTCGGCTGGC GCGGCGGCTT CCTGCTGCTC 
GGCGGGCTCC TGCTGCACTG CTGCGCCTGC GGGGCTGTCA TGAGGCCGCC GCCCGGGCCG 
GGCCCGCGAC CGCGCAGGGA CAGCGCCGGC GACCGCGCCG GGGACGCTCC GGGCGAGGCG 
GAGGCTGACG GTGCGGGGCT GCAGCTGCGC GAGGCATCCC CCAGGGTCCG GCCCCGCCGG 
CGCCTGCTGG ACTTGGCAGT GTGCACCGAC CGCGCCTTCG CCGTGTACGC CGTCACCAAG 
TTCCTGATGG CGCTCGGGCT CTTCGTCCCC GCCATCCTGC TGGTGAACTA CGCCAAGGAC 
GCGGGCGTGC CCGACACCGA CGCCGCCTTC CTGCTGTCCA TCGTGGGCTT CGTGGACATC 
GTGGCGCGCC CGGCGTGCGG CGCCCTGGCG GGCCTGGCGC GTCTGCGGCC GCACGTCCCG 
TATCTGTTCA GCCTGGCCCT GCTGGCCAAT GGGCTCACAG ACCTGAGCAG CGCACGCGCG 
CGCTCCTACG GCGCCCTCGT CGCCTTCTGC GTCGCCTTCG GCCTCTCCTA CGGCATGGTG 
GGCGCGCTGC AGTTCGAGGT GCTCATGGCG GCTGTGGGCG CGCCCCGCTT CCCCAGTGCG 
CTGGGCCTGG TGTTGCTCGT GGAGGCCGCG GCTGTGCTCA TCGGACCGCC CTCTGCCGGC 
CGCCTGGTGG ATGTGTTGAA GAACTATGAG ATCATCTTCT ACCTGGCCGG CTCTGAGGTG 
GCCCTGGCTG GGGTCTTCAT GGCTGTCGCC ACCAACTGCT GCCTGCGTTG TGCTAAAGCT 
GCCCCGTCAG GCCCAGGCAC TGAGGGCGGA GCCAGTGACA CTGAGGACGC TGAGGCTGAA 
GGGGACTCTG AGCCCCTGCC TGTTGTTGCA GAGGAACCCG GCAACCTGGA GGCCCTGGAG 
GTGCTCAGCG CCCGGGGCGA GCCCACAGAA CCAGAAATAG AGGCGAGGCC GAGGCTGGCT 
GCCGAGTCTG TATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SLC16A8 ( XM_017028685.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016884174.1 Homo sapiens solute carrier family 16 member 8 (SLC16A8), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu06468
Clone ID Related Accession (Same CDS sequence)	NM_013356.2 , NM_013356.3 , XM_017028685.1
Accession Version	XM_017028685.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1515bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	monocarboxylate transporter 3 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000022.11) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGGCGCTG GCGGCCCCCG GCGGGGCGAG GGCCCCCCAG ACGGCGGCTG GGGCTGGGTG 
GTGCTGGGCG CCTGCTTTGT GGTCACCGGC TTCGCCTACG GCTTCCCCAA AGCCGTGAGC 
GTCTTCTTCC GCGCGCTCAT GCGCGACTTC GACGCCGGCT ACAGCGACAC GGCCTGGGTG 
TCCTCCATCA TGCTAGCCAT GCTCTACGGC ACGGGCCCCG TGTCCAGCAT CCTCGTGACC 
CGCTTTGGCT GTCGCCCGGT GATGCTGGCG GGTGGGCTGC TGGCTTCCGC GGGCATGATC 
CTAGCTTCCT TTGCCACGCG CCTCCTGGAG CTCTACCTGA CCGCTGGGGT GCTCACAGGC 
CTGGGCCTGG CCCTCAACTT CCAGCCGTCG CTCATCATGC TGGGGCTGTA CTTCGAGCGG 
CGGCGGCCTC TGGCCAACGG GCTGGCGGCG GCGGGCAGCC CCGTGTTCCT GTCCGCGCTG 
TCGCCGCTCG GCCAGCAGCT GCTGGAGCGC TTCGGCTGGC GCGGCGGCTT CCTGCTGCTC 
GGCGGGCTCC TGCTGCACTG CTGCGCCTGC GGGGCTGTCA TGAGGCCGCC GCCCGGGCCG 
GGCCCGCGAC CGCGCAGGGA CAGCGCCGGC GACCGCGCCG GGGACGCTCC GGGCGAGGCG 
GAGGCTGACG GTGCGGGGCT GCAGCTGCGC GAGGCATCCC CCAGGGTCCG GCCCCGCCGG 
CGCCTGCTGG ACTTGGCAGT GTGCACCGAC CGCGCCTTCG CCGTGTACGC CGTCACCAAG 
TTCCTGATGG CGCTCGGGCT CTTCGTCCCC GCCATCCTGC TGGTGAACTA CGCCAAGGAC 
GCGGGCGTGC CCGACACCGA CGCCGCCTTC CTGCTGTCCA TCGTGGGCTT CGTGGACATC 
GTGGCGCGCC CGGCGTGCGG CGCCCTGGCG GGCCTGGCGC GTCTGCGGCC GCACGTCCCG 
TATCTGTTCA GCCTGGCCCT GCTGGCCAAT GGGCTCACAG ACCTGAGCAG CGCACGCGCG 
CGCTCCTACG GCGCCCTCGT CGCCTTCTGC GTCGCCTTCG GCCTCTCCTA CGGCATGGTG 
GGCGCGCTGC AGTTCGAGGT GCTCATGGCG GCTGTGGGCG CGCCCCGCTT CCCCAGTGCG 
CTGGGCCTGG TGTTGCTCGT GGAGGCCGCG GCTGTGCTCA TCGGACCGCC CTCTGCCGGC 
CGCCTGGTGG ATGTGTTGAA GAACTATGAG ATCATCTTCT ACCTGGCCGG CTCTGAGGTG 
GCCCTGGCTG GGGTCTTCAT GGCTGTCGCC ACCAACTGCT GCCTGCGTTG TGCTAAAGCT 
GCCCCGTCAG GCCCAGGCAC TGAGGGCGGA GCCAGTGACA CTGAGGACGC TGAGGCTGAA 
GGGGACTCTG AGCCCCTGCC TGTTGTTGCA GAGGAACCCG GCAACCTGGA GGCCCTGGAG 
GTGCTCAGCG CCCGGGGCGA GCCCACAGAA CCAGAAATAG AGGCGAGGCC GAGGCTGGCT 
GCCGAGTCTG TATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016884174.1
CDS	186..1700
Translation	MGAGGPRRGEGPPDGGWGWVVLGACFVVTGFAYGFPKAVSVFFRALMRDFDAGYSDTAWVSSIMLAMLYGTGPVSSILVTRFGCRPVMLAGGLLASAGMILASFATRLLELYLTAGVLTGLGLALNFQPSLIMLGLYFERRRPLANGLAAAGSPVFLSALSPLGQQLLERFGWRGGFLLLGGLLLHCCACGAVMRPPPGPGPRPRRDSAGDRAGDAPGEAEADGAGLQLREASPRVRPRRRLLDLAVCTDRAFAVYAVTKFLMALGLFVPAILLVNYAKDAGVPDTDAAFLLSIVGFVDIVARPACGALAGLARLRPHVPYLFSLALLANGLTDLSSARARSYGALVAFCVAFGLSYGMVGALQFEVLMAAVGAPRFPSALGLVLLVEAAAVLIGPPSAGRLVDVLKNYEIIFYLAGSEVALAGVFMAVATNCCLRCAKAAPSGPGTEGGASDTEDAEAEGDSEPLPVVAEEPGNLEALEVLSARGEPTEPEIEARPRLAAESV

Target ORF information:

RefSeq Version	XM_017028685.1
Organism	Homo sapiens(human)
Definition	Homo sapiens solute carrier family 16 member 8 (SLC16A8), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017028685.1

ORF Insert Sequence:

ATGGGCGCTG GCGGCCCCCG GCGGGGCGAG GGCCCCCCAG ACGGCGGCTG GGGCTGGGTG 
GTGCTGGGCG CCTGCTTTGT GGTCACCGGC TTCGCCTACG GCTTCCCCAA AGCCGTGAGC 
GTCTTCTTCC GCGCGCTCAT GCGCGACTTC GACGCCGGCT ACAGCGACAC GGCCTGGGTG 
TCCTCCATCA TGCTAGCCAT GCTCTACGGC ACGGGCCCCG TGTCCAGCAT CCTCGTGACC 
CGCTTTGGCT GTCGCCCGGT GATGCTGGCG GGTGGGCTGC TGGCTTCCGC GGGCATGATC 
CTAGCTTCCT TTGCCACGCG CCTCCTGGAG CTCTACCTGA CCGCTGGGGT GCTCACAGGC 
CTGGGCCTGG CCCTCAACTT CCAGCCGTCG CTCATCATGC TGGGGCTGTA CTTCGAGCGG 
CGGCGGCCTC TGGCCAACGG GCTGGCGGCG GCGGGCAGCC CCGTGTTCCT GTCCGCGCTG 
TCGCCGCTCG GCCAGCAGCT GCTGGAGCGC TTCGGCTGGC GCGGCGGCTT CCTGCTGCTC 
GGCGGGCTCC TGCTGCACTG CTGCGCCTGC GGGGCTGTCA TGAGGCCGCC GCCCGGGCCG 
GGCCCGCGAC CGCGCAGGGA CAGCGCCGGC GACCGCGCCG GGGACGCTCC GGGCGAGGCG 
GAGGCTGACG GTGCGGGGCT GCAGCTGCGC GAGGCATCCC CCAGGGTCCG GCCCCGCCGG 
CGCCTGCTGG ACTTGGCAGT GTGCACCGAC CGCGCCTTCG CCGTGTACGC CGTCACCAAG 
TTCCTGATGG CGCTCGGGCT CTTCGTCCCC GCCATCCTGC TGGTGAACTA CGCCAAGGAC 
GCGGGCGTGC CCGACACCGA CGCCGCCTTC CTGCTGTCCA TCGTGGGCTT CGTGGACATC 
GTGGCGCGCC CGGCGTGCGG CGCCCTGGCG GGCCTGGCGC GTCTGCGGCC GCACGTCCCG 
TATCTGTTCA GCCTGGCCCT GCTGGCCAAT GGGCTCACAG ACCTGAGCAG CGCACGCGCG 
CGCTCCTACG GCGCCCTCGT CGCCTTCTGC GTCGCCTTCG GCCTCTCCTA CGGCATGGTG 
GGCGCGCTGC AGTTCGAGGT GCTCATGGCG GCTGTGGGCG CGCCCCGCTT CCCCAGTGCG 
CTGGGCCTGG TGTTGCTCGT GGAGGCCGCG GCTGTGCTCA TCGGACCGCC CTCTGCCGGC 
CGCCTGGTGG ATGTGTTGAA GAACTATGAG ATCATCTTCT ACCTGGCCGG CTCTGAGGTG 
GCCCTGGCTG GGGTCTTCAT GGCTGTCGCC ACCAACTGCT GCCTGCGTTG TGCTAAAGCT 
GCCCCGTCAG GCCCAGGCAC TGAGGGCGGA GCCAGTGACA CTGAGGACGC TGAGGCTGAA 
GGGGACTCTG AGCCCCTGCC TGTTGTTGCA GAGGAACCCG GCAACCTGGA GGCCCTGGAG 
GTGCTCAGCG CCCGGGGCGA GCCCACAGAA CCAGAAATAG AGGCGAGGCC GAGGCTGGCT 
GCCGAGTCTG TATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Serum Levels of TIMP-3, LIPC, IER3, and SLC16A8 in CFH-Negative AMD Cases.
Journal of cellular biochemistry118(8)2087-2095(2017 Aug)
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Seven new loci associated with age-related macular degeneration.
Nature genetics45(4)433-9, 439e1-2(2013 Apr)
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L-type voltage-dependent calcium channel alpha subunit 1C is a novel candidate gene associated with secondary hyperparathyroidism: an application of haplotype-based analysis for multiple linked single nucleotide polymorphisms.
Nephron. Clinical practice115(4)c237-43(2010)
Yokoyama K,Urashima M,Ohkido I,Kono T,Yoshida T,Muramatsu M,Niu T,Hosoya T

Basigin (CD147) is the target for organomercurial inhibition of monocarboxylate transporter isoforms 1 and 4: the ancillary protein for the insensitive MCT2 is EMBIGIN (gp70).
The Journal of biological chemistry280(29)27213-21(2005 Jul)
Wilson MC,Meredith D,Fox JE,Manoharan C,Davies AJ,Halestrap AP

The SLC16 gene family-from monocarboxylate transporters (MCTs) to aromatic amino acid transporters and beyond.
Pflugers Archiv : European journal of physiology447(5)619-28(2004 Feb)
Halestrap AP,Meredith D