NR2F6 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	NR2F6
Entrez Gene ID	2063
Full Name	nuclear receptor subfamily 2 group F member 6
Synonyms	EAR-2,EAR2,ERBAL2
General protein information	Preferred Names nuclear receptor subfamily 2 group F member 6 Names nuclear receptor subfamily 2 group F member 6 ERBA-related gene-2 V-erbA-related protein 2 nuclear receptor V-erbA-related v-erb-a avian erythroblastic leukemia viral oncogene homolog-like 2
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 19 Map Location: 19p13.11
Disorder MIM:	132880

mRNA and Protein(s)

mRNA	Protein	Name
NM_005234.3	NP_005225.2	nuclear receptor subfamily 2 group F member 6

Pathways from BioSystems

Homologies

Bos taurus (cattle)	NR2F6	XP_002688591.2
Xenopus tropicalis (tropical clawed frog)	nr2f6	NP_001004841.1
Homo sapiens (human)	NR2F6	NP_005225.2
Danio rerio (zebrafish)	nr2f6b	NP_998404.1
Pan troglodytes (chimpanzee)	NR2F6	XP_001173294.1
Canis lupus familiaris (dog)	NR2F6	XP_852412.1
Rattus norvegicus (Norway rat)	Nr2f6	NP_620813.1
	NR2F6	XP_001114305.2
Mus musculus (house mouse)	Nr2f6	NP_034280.2
Danio rerio (zebrafish)	nr2f6a	NP_991120.1

Gene Ontology
Bibliography

Related articles in PubMed

Association between polymorphisms in microRNA target sites and survival in early-stage non-small cell lung cancer.
Yoo SS, Hong MJ, Lee JH, Choi JE, Lee SY, Lee J, Cha SI, Kim CH, Seok Y, Lee E, Cho S, Jheon S, Park JY
Thoracic cancer8(6)682-686(2017 Nov)

NR2F6 Expression Correlates with Pelvic Lymph Node Metastasis and Poor Prognosis in Early-Stage Cervical Cancer.
Niu C, Sun X, Zhang W, Li H, Xu L, Li J, Xu B, Zhang Y
International journal of molecular sciences17(10)(2016 Oct)

A signature motif mediating selective interactions of BCL11A with the NR2E/F subfamily of orphan nuclear receptors.
Chan CM, Fulton J, Montiel-Duarte C, Collins HM, Bharti N, Wadelin FR, Moran PM, Mongan NP, Heery DM
Nucleic acids research41(21)9663-79(2013 Nov)

The orphan nuclear receptor EAR2 is overexpressed in colorectal cancer and it regulates survivability of colon cancer cells.
Li XB, Jiao S, Sun H, Xue J, Zhao WT, Fan L, Wu GH, Fang J
Cancer letters309(2)137-44(2011 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

high NR2F6 expression predicts pelvic lymph node metastasis, tumor recurrence and poor prognosis in early-stage cervical cancer. NR2F6 might be a novel prognostic biomarker and potential therapeutic target of cervical cancer.
Title: NR2F6 Expression Correlates with Pelvic Lymph Node Metastasis and Poor Prognosis in Early-Stage Cervical Cancer.

Interaction of NSD1 with the NR2E/F subfamily including COUP-TFI, COUP-TFII, EAR2 and TLX requires a F/YSXXLXXL/Y motif. NSD1 interaction with liganded NRs is mediated by an overlapping LXXLL motif.
Title: A signature motif mediating selective interactions of BCL11A with the NR2E/F subfamily of orphan nuclear receptors.

study demonstrated that expression of EAR2 was elevated in colorectal cancer and knockdown of EAR2 reduced survivability and tumor growth of colon cancer cells
Title: The orphan nuclear receptor EAR2 is overexpressed in colorectal cancer and it regulates survivability of colon cancer cells.

Ear2 ligand binding domain is required for Rasd1 to alleviate Ear2-mediated repression of renin transcription.
Title: Rasd1 interacts with Ear2 (Nr2f6) to regulate renin transcription.

The following NR2F6 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the NR2F6 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu04840	NM_005234.3 Latest version!	Homo sapiens nuclear receptor subfamily 2 group F member 6 (NR2F6), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

NR2F6 ( NM_005234.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_005225.2 Homo sapiens nuclear receptor subfamily 2 group F member 6 (NR2F6), mRNA.

Price & Availability↑

CloneID	OHu04840
Clone ID Related Accession (Same CDS sequence)	NM_005234.3
Accession Version	NM_005234.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1215bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-26
Organism	Homo sapiens(human)
Product	nuclear receptor subfamily 2 group F member 6
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC002669.2. On Apr 20, 2004 this sequence version replaced NM_005234.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC002669.2, ERR279853.518.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA2153427 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##

ATGGCCATGG TGACCGGCGG CTGGGGCGGC CCCGGCGGCG ACACGAACGG CGTGGACAAG 
GCGGGCGGCT ACCCGCGCGC GGCCGAGGAC GACTCGGCCT CGCCCCCCGG TGCCGCCAGC 
GACGCCGAGC CGGGCGACGA GGAGCGGCCG GGGCTGCAGG TGGACTGCGT GGTGTGCGGG 
GACAAGTCGA GCGGCAAGCA TTACGGTGTC TTCACCTGCG AGGGCTGCAA GAGCTTTTTC 
AAGCGAAGCA TCCGCCGCAA CCTCAGCTAC ACCTGCCGGT CCAACCGTGA CTGCCAGATC 
GACCAGCACC ACCGGAACCA GTGCCAGTAC TGCCGTCTCA AGAAGTGCTT CCGGGTGGGC 
ATGAGGAAGG AGGCGGTGCA GCGCGGCCGC ATCCCGCACT CGCTGCCTGG TGCCGTGGCC 
GCCTCCTCGG GCAGCCCCCC GGGCTCGGCG CTGGCGGCAG TGGCGAGCGG CGGAGACCTC 
TTCCCGGGGC AGCCGGTGTC CGAACTGATC GCGCAGCTGC TGCGCGCTGA GCCCTACCCT 
GCGGCGGCCG GACGCTTCGG CGCAGGGGGC GGCGCGGCGG GCGCGGTGCT GGGCATCGAC 
AACGTGTGCG AGCTGGCGGC GCGGCTGCTC TTCAGCACCG TGGAGTGGGC GCGCCACGCG 
CCCTTCTTCC CCGAGCTGCC GGTGGCCGAC CAGGTGGCGC TGCTGCGCCT GAGCTGGAGC 
GAGCTCTTCG TGCTGAACGC GGCGCAGGCG GCGCTGCCCC TGCACACGGC GCCGCTACTG 
GCCGCCGCCG GCCTCCACGC CGCGCCTATG GCCGCCGAGC GCGCCGTGGC TTTCATGGAC 
CAGGTGCGCG CCTTCCAGGA GCAGGTGGAC AAGCTGGGCC GCCTGCAGGT CGACTCGGCC 
GAGTATGGCT GCCTCAAGGC CATCGCGCTC TTCACGCCCG ACGCCTGTGG CCTCTCAGAC 
CCGGCCCACG TTGAGAGCCT GCAGGAGAAG GCGCAGGTGG CCCTCACCGA GTATGTGCGG 
GCGCAGTACC CGTCCCAGCC CCAGCGCTTC GGGCGCCTGC TGCTGCGGCT CCCCGCCCTG 
CGCGCGGTCC CTGCCTCCCT CATCTCCCAG CTGTTCTTCA TGCGCCTGGT GGGGAAGACG 
CCCATTGAGA CACTGATCAG AGACATGCTG CTGTCGGGGA GTACCTTCAA CTGGCCCTAC 
GGCTCGGGCC AGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005225.2
CDS	123..1337
Translation	MAMVTGGWGGPGGDTNGVDKAGGYPRAAEDDSASPPGAASDAEPGDEERPGLQVDCVVCGDKSSGKHYGVFTCEGCKSFFKRSIRRNLSYTCRSNRDCQIDQHHRNQCQYCRLKKCFRVGMRKEAVQRGRIPHSLPGAVAASSGSPPGSALAAVASGGDLFPGQPVSELIAQLLRAEPYPAAAGRFGAGGGAAGAVLGIDNVCELAARLLFSTVEWARHAPFFPELPVADQVALLRLSWSELFVLNAAQAALPLHTAPLLAAAGLHAAPMAAERAVAFMDQVRAFQEQVDKLGRLQVDSAEYGCLKAIALFTPDACGLSDPAHVESLQEKAQVALTEYVRAQYPSQPQRFGRLLLRLPALRAVPASLISQLFFMRLVGKTPIETLIRDMLLSGSTFNWPYGSGQ

Target ORF information:

RefSeq Version	NM_005234.3
Organism	Homo sapiens(human)
Definition	Homo sapiens nuclear receptor subfamily 2 group F member 6 (NR2F6), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005234.3

ORF Insert Sequence:

ATGGCCATGG TGACCGGCGG CTGGGGCGGC CCCGGCGGCG ACACGAACGG CGTGGACAAG 
GCGGGCGGCT ACCCGCGCGC GGCCGAGGAC GACTCGGCCT CGCCCCCCGG TGCCGCCAGC 
GACGCCGAGC CGGGCGACGA GGAGCGGCCG GGGCTGCAGG TGGACTGCGT GGTGTGCGGG 
GACAAGTCGA GCGGCAAGCA TTACGGTGTC TTCACCTGCG AGGGCTGCAA GAGCTTTTTC 
AAGCGAAGCA TCCGCCGCAA CCTCAGCTAC ACCTGCCGGT CCAACCGTGA CTGCCAGATC 
GACCAGCACC ACCGGAACCA GTGCCAGTAC TGCCGTCTCA AGAAGTGCTT CCGGGTGGGC 
ATGAGGAAGG AGGCGGTGCA GCGCGGCCGC ATCCCGCACT CGCTGCCTGG TGCCGTGGCC 
GCCTCCTCGG GCAGCCCCCC GGGCTCGGCG CTGGCGGCAG TGGCGAGCGG CGGAGACCTC 
TTCCCGGGGC AGCCGGTGTC CGAACTGATC GCGCAGCTGC TGCGCGCTGA GCCCTACCCT 
GCGGCGGCCG GACGCTTCGG CGCAGGGGGC GGCGCGGCGG GCGCGGTGCT GGGCATCGAC 
AACGTGTGCG AGCTGGCGGC GCGGCTGCTC TTCAGCACCG TGGAGTGGGC GCGCCACGCG 
CCCTTCTTCC CCGAGCTGCC GGTGGCCGAC CAGGTGGCGC TGCTGCGCCT GAGCTGGAGC 
GAGCTCTTCG TGCTGAACGC GGCGCAGGCG GCGCTGCCCC TGCACACGGC GCCGCTACTG 
GCCGCCGCCG GCCTCCACGC CGCGCCTATG GCCGCCGAGC GCGCCGTGGC TTTCATGGAC 
CAGGTGCGCG CCTTCCAGGA GCAGGTGGAC AAGCTGGGCC GCCTGCAGGT CGACTCGGCC 
GAGTATGGCT GCCTCAAGGC CATCGCGCTC TTCACGCCCG ACGCCTGTGG CCTCTCAGAC 
CCGGCCCACG TTGAGAGCCT GCAGGAGAAG GCGCAGGTGG CCCTCACCGA GTATGTGCGG 
GCGCAGTACC CGTCCCAGCC CCAGCGCTTC GGGCGCCTGC TGCTGCGGCT CCCCGCCCTG 
CGCGCGGTCC CTGCCTCCCT CATCTCCCAG CTGTTCTTCA TGCGCCTGGT GGGGAAGACG 
CCCATTGAGA CACTGATCAG AGACATGCTG CTGTCGGGGA GTACCTTCAA CTGGCCCTAC 
GGCTCGGGCC AGTGA