KCTD6 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	KCTD6
Entrez Gene ID	200845
Full Name	potassium channel tetramerization domain containing 6
Synonyms	KCASH3
General protein information	Preferred Names potassium channel tetramerization domain containing 6 Names BTB/POZ domain-containing protein KCTD6 potassium channel tetramerisation domain containing 6 potassium channel tetramerization domain-containing protein 6
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 3 Map Location: 3p14.3

mRNA and Protein(s)

mRNA	Protein	Name
NM_153331.3	NP_699162.3	BTB/POZ domain-containing protein KCTD6
NM_001128214.2	NP_001121686.1	BTB/POZ domain-containing protein KCTD6
XM_005264937.2	XP_005264994.1	BTB/POZ domain-containing protein KCTD6 isoform X1
NM_001128214.1	NP_001121686.1	BTB/POZ domain-containing protein KCTD6

Pathways from BioSystems

Homologies

Homo sapiens (human)	KCTD6	NP_001121686.1
	LOC701810	XP_001096089.1
Rattus norvegicus (Norway rat)	Kctd6	NP_001100723.1
Xenopus tropicalis (tropical clawed frog)	kctd6	NP_001135600.1
Gallus gallus (chicken)	KCTD6	XP_414405.1
Danio rerio (zebrafish)	kctd6a	NP_001074463.1
Bos taurus (cattle)	KCTD6	NP_001094694.1
Pan troglodytes (chimpanzee)	KCTD6	XP_001174242.1
Mus musculus (house mouse)	Kctd6	NP_082058.1
Canis lupus familiaris (dog)	KCTD6	XP_005632440.1

Gene Ontology
Bibliography

Related articles in PubMed

The BTB domains of the potassium channel tetramerization domain proteins prevalently assume pentameric states.
Smaldone G, Pirone L, Pedone E, Marlovits T, Vitagliano L, Ciccarelli L
FEBS letters590(11)1663-71(2016 Jun)

Widespread macromolecular interaction perturbations in human genetic disorders.
Sahni N, Yi S, Taipale M, Fuxman Bass JI, Coulombe-Huntington J, Yang F, Peng J, Weile J, Karras GI, Wang Y, Kov?cs IA, Kamburov A, Krykbaeva I, Lam MH, Tucker G, Khurana V, Sharma A, Liu YY, Yachie N, Zhong Q, Shen Y, Palagi A, San-Miguel A, Fan C, Balcha D, Dricot A, Jordan DM, Walsh JM, Shah AA, Yang X, Stoyanova AK, Leighton A, Calderwood MA, Jacob Y, Cusick ME, Salehi-Ashtiani K, Whitesell LJ, Sunyaev S, Berger B, Barab?si AL, Charloteaux B, Hill DE, Hao T, Roth FP, Xia Y, Walhout AJM, Lindquist S, Vidal M
Cell161(3)647-660(2015 Apr)

Thermal and chemical stability of two homologous POZ/BTB domains of KCTD proteins characterized by a different oligomeric organization.
Pirone L, Esposito C, Correale S, Graziano G, Di Gaetano S, Vitagliano L, Pedone E
BioMed research international2013162674(2013)

Obscurin and KCTD6 regulate cullin-dependent small ankyrin-1 (sAnk1.5) protein turnover.
Lange S, Perera S, Teh P, Chen J
Molecular biology of the cell23(13)2490-504(2012 Jul)

Identification and characterization of KCASH2 and KCASH3, 2 novel Cullin3 adaptors suppressing histone deacetylase and Hedgehog activity in medulloblastoma.
De Smaele E, Di Marcotullio L, Moretti M, Pelloni M, Occhione MA, Infante P, Cucchi D, Greco A, Pietrosanti L, Todorovic J, Coni S, Canettieri G, Ferretti E, Bei R, Maroder M, Screpanti I, Gulino A
Neoplasia (New York, N.Y.)13(4)374-85(2011 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

A biophysical characterization of the POZ/BTB of KCTD6, is reported.
Title: Thermal and chemical stability of two homologous POZ/BTB domains of KCTD proteins characterized by a different oligomeric organization.

Obscurin and KCTD6 regulate cullin-dependent small ankyrin-1 (sAnk1.5) protein turnover
Title: Obscurin and KCTD6 regulate cullin-dependent small ankyrin-1 (sAnk1.5) protein turnover.

Rescuing KCASHs expression reduces the Hedgehog-dependent medulloblastoma growth, suggesting that loss of members of this novel family of native HDAC inhibitors is crucial in sustaining Hh pathway-mediated tumorigenesis.
Title: Identification and characterization of KCASH2 and KCASH3, 2 novel Cullin3 adaptors suppressing histone deacetylase and Hedgehog activity in medulloblastoma.

The following KCTD6 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the KCTD6 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu31919	NM_153331.3 Latest version!	Homo sapiens potassium channel tetramerization domain containing 6 (KCTD6), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu31919	NM_001128214.2 Latest version!	Homo sapiens potassium channel tetramerization domain containing 6 (KCTD6), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu31919	XM_005264937.2 Latest version!	Homo sapiens potassium channel tetramerization domain containing 6 (KCTD6), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu31919	NM_001128214.1	Homo sapiens potassium channel tetramerization domain containing 6 (KCTD6), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

KCTD6 ( NM_153331.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_699162.3 Homo sapiens potassium channel tetramerization domain containing 6 (KCTD6), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu31919
Clone ID Related Accession (Same CDS sequence)	NM_153331.3 , NM_001128214.2 , XM_005264937.2 , NM_001128214.1
Accession Version	NM_153331.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 714bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Homo sapiens(human)
Product	BTB/POZ domain-containing protein KCTD6
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK074934.1, BC022893.1 and AA721100.1. On Jun 10, 2008 this sequence version replaced NM_153331.2. Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein. ##Evidence-Data-START## Transcript exon combination :: AK074934.1, AK027572.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGATAATG GAGACTGGGG CTATATGATG ACTGACCCAG TCACATTAAA TGTAGGTGGA 
CACTTGTATA CAACGTCTCT CACCACATTG ACGCGTTACC CGGATTCCAT GCTTGGAGCT 
ATGTTTGGGG GGGACTTCCC CACAGCTCGA GACCCTCAAG GCAATTACTT TATTGATCGA 
GATGGACCTC TTTTCCGATA TGTCCTCAAC TTCTTAAGAA CTTCAGAATT GACCTTACCG 
TTGGATTTTA AGGAATTTGA TCTGCTTCGG AAAGAAGCAG ATTTTTACCA GATTGAGCCC 
TTGATTCAGT GTCTCAATGA TCCTAAGCCT TTGTATCCCA TGGATACTTT TGAAGAAGTT 
GTGGAGCTGT CTAGTACTCG GAAGCTTTCT AAGTACTCCA ACCCAGTGGC TGTCATCATA 
ACGCAACTAA CCATCACCAC TAAGGTCCAT TCCTTACTAG AAGGCATCTC AAATTATTTT 
ACCAAGTGGA ATAAGCACAT GATGGACACC AGAGACTGCC AGGTTTCCTT TACTTTTGGA 
CCCTGTGATT ATCACCAGGA AGTTTCTCTT AGGGTCCACC TGATGGAATA CATTACAAAA 
CAAGGTTTCA CGATCCGCAA CACCCGGGTG CATCACATGA GTGAGCGGGC CAATGAAAAC 
ACAGTGGAGC ACAACTGGAC TTTCTGTAGG CTAGCCCGGA AGACAGACGA CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_699162.3
CDS	392..1105
Translation	MDNGDWGYMMTDPVTLNVGGHLYTTSLTTLTRYPDSMLGAMFGGDFPTARDPQGNYFIDRDGPLFRYVLNFLRTSELTLPLDFKEFDLLRKEADFYQIEPLIQCLNDPKPLYPMDTFEEVVELSSTRKLSKYSNPVAVIITQLTITTKVHSLLEGISNYFTKWNKHMMDTRDCQVSFTFGPCDYHQEVSLRVHLMEYITKQGFTIRNTRVHHMSERANENTVEHNWTFCRLARKTDD

Target ORF information:

RefSeq Version	NM_153331.3
Organism	Homo sapiens(human)
Definition	Homo sapiens potassium channel tetramerization domain containing 6 (KCTD6), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_153331.3

ORF Insert Sequence:

ATGGATAATG GAGACTGGGG CTATATGATG ACTGACCCAG TCACATTAAA TGTAGGTGGA 
CACTTGTATA CAACGTCTCT CACCACATTG ACGCGTTACC CGGATTCCAT GCTTGGAGCT 
ATGTTTGGGG GGGACTTCCC CACAGCTCGA GACCCTCAAG GCAATTACTT TATTGATCGA 
GATGGACCTC TTTTCCGATA TGTCCTCAAC TTCTTAAGAA CTTCAGAATT GACCTTACCG 
TTGGATTTTA AGGAATTTGA TCTGCTTCGG AAAGAAGCAG ATTTTTACCA GATTGAGCCC 
TTGATTCAGT GTCTCAATGA TCCTAAGCCT TTGTATCCCA TGGATACTTT TGAAGAAGTT 
GTGGAGCTGT CTAGTACTCG GAAGCTTTCT AAGTACTCCA ACCCAGTGGC TGTCATCATA 
ACGCAACTAA CCATCACCAC TAAGGTCCAT TCCTTACTAG AAGGCATCTC AAATTATTTT 
ACCAAGTGGA ATAAGCACAT GATGGACACC AGAGACTGCC AGGTTTCCTT TACTTTTGGA 
CCCTGTGATT ATCACCAGGA AGTTTCTCTT AGGGTCCACC TGATGGAATA CATTACAAAA 
CAAGGTTTCA CGATCCGCAA CACCCGGGTG CATCACATGA GTGAGCGGGC CAATGAAAAC 
ACAGTGGAGC ACAACTGGAC TTTCTGTAGG CTAGCCCGGA AGACAGACGA CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

KCTD6 ( NM_001128214.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001121686.1 Homo sapiens potassium channel tetramerization domain containing 6 (KCTD6), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu31919
Clone ID Related Accession (Same CDS sequence)	NM_153331.3 , NM_001128214.2 , XM_005264937.2 , NM_001128214.1
Accession Version	NM_001128214.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 714bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-26
Organism	Homo sapiens(human)
Product	BTB/POZ domain-containing protein KCTD6
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DA359951.1, BC022893.1 and AA721100.1. On Nov 23, 2018 this sequence version replaced NM_001128214.1. Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein. ##Evidence-Data-START## Transcript exon combination :: SRR3476690.310628.1, SRR3476690.415114.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000404589.8/ ENSP00000384948.3 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGATAATG GAGACTGGGG CTATATGATG ACTGACCCAG TCACATTAAA TGTAGGTGGA 
CACTTGTATA CAACGTCTCT CACCACATTG ACGCGTTACC CGGATTCCAT GCTTGGAGCT 
ATGTTTGGGG GGGACTTCCC CACAGCTCGA GACCCTCAAG GCAATTACTT TATTGATCGA 
GATGGACCTC TTTTCCGATA TGTCCTCAAC TTCTTAAGAA CTTCAGAATT GACCTTACCG 
TTGGATTTTA AGGAATTTGA TCTGCTTCGG AAAGAAGCAG ATTTTTACCA GATTGAGCCC 
TTGATTCAGT GTCTCAATGA TCCTAAGCCT TTGTATCCCA TGGATACTTT TGAAGAAGTT 
GTGGAGCTGT CTAGTACTCG GAAGCTTTCT AAGTACTCCA ACCCAGTGGC TGTCATCATA 
ACGCAACTAA CCATCACCAC TAAGGTCCAT TCCTTACTAG AAGGCATCTC AAATTATTTT 
ACCAAGTGGA ATAAGCACAT GATGGACACC AGAGACTGCC AGGTTTCCTT TACTTTTGGA 
CCCTGTGATT ATCACCAGGA AGTTTCTCTT AGGGTCCACC TGATGGAATA CATTACAAAA 
CAAGGTTTCA CGATCCGCAA CACCCGGGTG CATCACATGA GTGAGCGGGC CAATGAAAAC 
ACAGTGGAGC ACAACTGGAC TTTCTGTAGG CTAGCCCGGA AGACAGACGA CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001121686.1
CDS	118..831
Translation	MDNGDWGYMMTDPVTLNVGGHLYTTSLTTLTRYPDSMLGAMFGGDFPTARDPQGNYFIDRDGPLFRYVLNFLRTSELTLPLDFKEFDLLRKEADFYQIEPLIQCLNDPKPLYPMDTFEEVVELSSTRKLSKYSNPVAVIITQLTITTKVHSLLEGISNYFTKWNKHMMDTRDCQVSFTFGPCDYHQEVSLRVHLMEYITKQGFTIRNTRVHHMSERANENTVEHNWTFCRLARKTDD

Target ORF information:

RefSeq Version	NM_001128214.2
Organism	Homo sapiens(human)
Definition	Homo sapiens potassium channel tetramerization domain containing 6 (KCTD6), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001128214.2

ORF Insert Sequence:

ATGGATAATG GAGACTGGGG CTATATGATG ACTGACCCAG TCACATTAAA TGTAGGTGGA 
CACTTGTATA CAACGTCTCT CACCACATTG ACGCGTTACC CGGATTCCAT GCTTGGAGCT 
ATGTTTGGGG GGGACTTCCC CACAGCTCGA GACCCTCAAG GCAATTACTT TATTGATCGA 
GATGGACCTC TTTTCCGATA TGTCCTCAAC TTCTTAAGAA CTTCAGAATT GACCTTACCG 
TTGGATTTTA AGGAATTTGA TCTGCTTCGG AAAGAAGCAG ATTTTTACCA GATTGAGCCC 
TTGATTCAGT GTCTCAATGA TCCTAAGCCT TTGTATCCCA TGGATACTTT TGAAGAAGTT 
GTGGAGCTGT CTAGTACTCG GAAGCTTTCT AAGTACTCCA ACCCAGTGGC TGTCATCATA 
ACGCAACTAA CCATCACCAC TAAGGTCCAT TCCTTACTAG AAGGCATCTC AAATTATTTT 
ACCAAGTGGA ATAAGCACAT GATGGACACC AGAGACTGCC AGGTTTCCTT TACTTTTGGA 
CCCTGTGATT ATCACCAGGA AGTTTCTCTT AGGGTCCACC TGATGGAATA CATTACAAAA 
CAAGGTTTCA CGATCCGCAA CACCCGGGTG CATCACATGA GTGAGCGGGC CAATGAAAAC 
ACAGTGGAGC ACAACTGGAC TTTCTGTAGG CTAGCCCGGA AGACAGACGA CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

KCTD6 ( NM_001128214.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001121686.1 Homo sapiens potassium channel tetramerization domain containing 6 (KCTD6), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu31919
Clone ID Related Accession (Same CDS sequence)	NM_153331.3 , NM_001128214.2 , XM_005264937.2 , NM_001128214.1
Accession Version	NM_001128214.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 714bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-31
Organism	Homo sapiens(human)
Product	BTB/POZ domain-containing protein KCTD6
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DA359951.1, BC022893.1 and AA721100.1. Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein. ##Evidence-Data-START## Transcript exon combination :: SRR1660803.346870.1, AK075297.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGATAATG GAGACTGGGG CTATATGATG ACTGACCCAG TCACATTAAA TGTAGGTGGA 
CACTTGTATA CAACGTCTCT CACCACATTG ACGCGTTACC CGGATTCCAT GCTTGGAGCT 
ATGTTTGGGG GGGACTTCCC CACAGCTCGA GACCCTCAAG GCAATTACTT TATTGATCGA 
GATGGACCTC TTTTCCGATA TGTCCTCAAC TTCTTAAGAA CTTCAGAATT GACCTTACCG 
TTGGATTTTA AGGAATTTGA TCTGCTTCGG AAAGAAGCAG ATTTTTACCA GATTGAGCCC 
TTGATTCAGT GTCTCAATGA TCCTAAGCCT TTGTATCCCA TGGATACTTT TGAAGAAGTT 
GTGGAGCTGT CTAGTACTCG GAAGCTTTCT AAGTACTCCA ACCCAGTGGC TGTCATCATA 
ACGCAACTAA CCATCACCAC TAAGGTCCAT TCCTTACTAG AAGGCATCTC AAATTATTTT 
ACCAAGTGGA ATAAGCACAT GATGGACACC AGAGACTGCC AGGTTTCCTT TACTTTTGGA 
CCCTGTGATT ATCACCAGGA AGTTTCTCTT AGGGTCCACC TGATGGAATA CATTACAAAA 
CAAGGTTTCA CGATCCGCAA CACCCGGGTG CATCACATGA GTGAGCGGGC CAATGAAAAC 
ACAGTGGAGC ACAACTGGAC TTTCTGTAGG CTAGCCCGGA AGACAGACGA CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001121686.1
CDS	118..831
Translation	MDNGDWGYMMTDPVTLNVGGHLYTTSLTTLTRYPDSMLGAMFGGDFPTARDPQGNYFIDRDGPLFRYVLNFLRTSELTLPLDFKEFDLLRKEADFYQIEPLIQCLNDPKPLYPMDTFEEVVELSSTRKLSKYSNPVAVIITQLTITTKVHSLLEGISNYFTKWNKHMMDTRDCQVSFTFGPCDYHQEVSLRVHLMEYITKQGFTIRNTRVHHMSERANENTVEHNWTFCRLARKTDD

Target ORF information:

RefSeq Version	NM_001128214.1
Organism	Homo sapiens(human)
Definition	Homo sapiens potassium channel tetramerization domain containing 6 (KCTD6), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001128214.1

ORF Insert Sequence:

ATGGATAATG GAGACTGGGG CTATATGATG ACTGACCCAG TCACATTAAA TGTAGGTGGA 
CACTTGTATA CAACGTCTCT CACCACATTG ACGCGTTACC CGGATTCCAT GCTTGGAGCT 
ATGTTTGGGG GGGACTTCCC CACAGCTCGA GACCCTCAAG GCAATTACTT TATTGATCGA 
GATGGACCTC TTTTCCGATA TGTCCTCAAC TTCTTAAGAA CTTCAGAATT GACCTTACCG 
TTGGATTTTA AGGAATTTGA TCTGCTTCGG AAAGAAGCAG ATTTTTACCA GATTGAGCCC 
TTGATTCAGT GTCTCAATGA TCCTAAGCCT TTGTATCCCA TGGATACTTT TGAAGAAGTT 
GTGGAGCTGT CTAGTACTCG GAAGCTTTCT AAGTACTCCA ACCCAGTGGC TGTCATCATA 
ACGCAACTAA CCATCACCAC TAAGGTCCAT TCCTTACTAG AAGGCATCTC AAATTATTTT 
ACCAAGTGGA ATAAGCACAT GATGGACACC AGAGACTGCC AGGTTTCCTT TACTTTTGGA 
CCCTGTGATT ATCACCAGGA AGTTTCTCTT AGGGTCCACC TGATGGAATA CATTACAAAA 
CAAGGTTTCA CGATCCGCAA CACCCGGGTG CATCACATGA GTGAGCGGGC CAATGAAAAC 
ACAGTGGAGC ACAACTGGAC TTTCTGTAGG CTAGCCCGGA AGACAGACGA CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

KCTD6 ( XM_005264937.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_005264994.1 Homo sapiens potassium channel tetramerization domain containing 6 (KCTD6), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu31919
Clone ID Related Accession (Same CDS sequence)	NM_153331.3 , NM_001128214.2 , XM_005264937.2 , NM_001128214.1
Accession Version	XM_005264937.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 714bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	BTB/POZ domain-containing protein KCTD6 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000003.12) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 12, 2015 this sequence version replaced XM_005264937.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGATAATG GAGACTGGGG CTATATGATG ACTGACCCAG TCACATTAAA TGTAGGTGGA 
CACTTGTATA CAACGTCTCT CACCACATTG ACGCGTTACC CGGATTCCAT GCTTGGAGCT 
ATGTTTGGGG GGGACTTCCC CACAGCTCGA GACCCTCAAG GCAATTACTT TATTGATCGA 
GATGGACCTC TTTTCCGATA TGTCCTCAAC TTCTTAAGAA CTTCAGAATT GACCTTACCG 
TTGGATTTTA AGGAATTTGA TCTGCTTCGG AAAGAAGCAG ATTTTTACCA GATTGAGCCC 
TTGATTCAGT GTCTCAATGA TCCTAAGCCT TTGTATCCCA TGGATACTTT TGAAGAAGTT 
GTGGAGCTGT CTAGTACTCG GAAGCTTTCT AAGTACTCCA ACCCAGTGGC TGTCATCATA 
ACGCAACTAA CCATCACCAC TAAGGTCCAT TCCTTACTAG AAGGCATCTC AAATTATTTT 
ACCAAGTGGA ATAAGCACAT GATGGACACC AGAGACTGCC AGGTTTCCTT TACTTTTGGA 
CCCTGTGATT ATCACCAGGA AGTTTCTCTT AGGGTCCACC TGATGGAATA CATTACAAAA 
CAAGGTTTCA CGATCCGCAA CACCCGGGTG CATCACATGA GTGAGCGGGC CAATGAAAAC 
ACAGTGGAGC ACAACTGGAC TTTCTGTAGG CTAGCCCGGA AGACAGACGA CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_005264994.1
CDS	1450..2163
Translation	MDNGDWGYMMTDPVTLNVGGHLYTTSLTTLTRYPDSMLGAMFGGDFPTARDPQGNYFIDRDGPLFRYVLNFLRTSELTLPLDFKEFDLLRKEADFYQIEPLIQCLNDPKPLYPMDTFEEVVELSSTRKLSKYSNPVAVIITQLTITTKVHSLLEGISNYFTKWNKHMMDTRDCQVSFTFGPCDYHQEVSLRVHLMEYITKQGFTIRNTRVHHMSERANENTVEHNWTFCRLARKTDD

Target ORF information:

RefSeq Version	XM_005264937.2
Organism	Homo sapiens(human)
Definition	Homo sapiens potassium channel tetramerization domain containing 6 (KCTD6), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_005264937.2

ORF Insert Sequence:

ATGGATAATG GAGACTGGGG CTATATGATG ACTGACCCAG TCACATTAAA TGTAGGTGGA 
CACTTGTATA CAACGTCTCT CACCACATTG ACGCGTTACC CGGATTCCAT GCTTGGAGCT 
ATGTTTGGGG GGGACTTCCC CACAGCTCGA GACCCTCAAG GCAATTACTT TATTGATCGA 
GATGGACCTC TTTTCCGATA TGTCCTCAAC TTCTTAAGAA CTTCAGAATT GACCTTACCG 
TTGGATTTTA AGGAATTTGA TCTGCTTCGG AAAGAAGCAG ATTTTTACCA GATTGAGCCC 
TTGATTCAGT GTCTCAATGA TCCTAAGCCT TTGTATCCCA TGGATACTTT TGAAGAAGTT 
GTGGAGCTGT CTAGTACTCG GAAGCTTTCT AAGTACTCCA ACCCAGTGGC TGTCATCATA 
ACGCAACTAA CCATCACCAC TAAGGTCCAT TCCTTACTAG AAGGCATCTC AAATTATTTT 
ACCAAGTGGA ATAAGCACAT GATGGACACC AGAGACTGCC AGGTTTCCTT TACTTTTGGA 
CCCTGTGATT ATCACCAGGA AGTTTCTCTT AGGGTCCACC TGATGGAATA CATTACAAAA 
CAAGGTTTCA CGATCCGCAA CACCCGGGTG CATCACATGA GTGAGCGGGC CAATGAAAAC 
ACAGTGGAGC ACAACTGGAC TTTCTGTAGG CTAGCCCGGA AGACAGACGA CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The BTB domains of the potassium channel tetramerization domain proteins prevalently assume pentameric states.
FEBS letters590(11)1663-71(2016 Jun)
Smaldone G,Pirone L,Pedone E,Marlovits T,Vitagliano L,Ciccarelli L

Widespread macromolecular interaction perturbations in human genetic disorders.
Cell161(3)647-660(2015 Apr)
Sahni N,Yi S,Taipale M,Fuxman Bass JI,Coulombe-Huntington J,Yang F,Peng J,Weile J,Karras GI,Wang Y,Kov?cs IA,Kamburov A,Krykbaeva I,Lam MH,Tucker G,Khurana V,Sharma A,Liu YY,Yachie N,Zhong Q,Shen Y,Palagi A,San-Miguel A,Fan C,Balcha D,Dricot A,Jordan DM,Walsh JM,Shah AA,Yang X,Stoyanova AK,Leighton A,Calderwood MA,Jacob Y,Cusick ME,Salehi-Ashtiani K,Whitesell LJ,Sunyaev S,Berger B,Barab?si AL,Charloteaux B,Hill DE,Hao T,Roth FP,Xia Y,Walhout AJM,Lindquist S,Vidal M

Thermal and chemical stability of two homologous POZ/BTB domains of KCTD proteins characterized by a different oligomeric organization.
BioMed research international2013162674(2013)
Pirone L,Esposito C,Correale S,Graziano G,Di Gaetano S,Vitagliano L,Pedone E

Obscurin and KCTD6 regulate cullin-dependent small ankyrin-1 (sAnk1.5) protein turnover.
Molecular biology of the cell23(13)2490-504(2012 Jul)
Lange S,Perera S,Teh P,Chen J

Identification and characterization of KCASH2 and KCASH3, 2 novel Cullin3 adaptors suppressing histone deacetylase and Hedgehog activity in medulloblastoma.
Neoplasia (New York, N.Y.)13(4)374-85(2011 Apr)
De Smaele E,Di Marcotullio L,Moretti M,Pelloni M,Occhione MA,Infante P,Cucchi D,Greco A,Pietrosanti L,Todorovic J,Coni S,Canettieri G,Ferretti E,Bei R,Maroder M,Screpanti I,Gulino A

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KCTD6 cDNA ORF clone, Homo sapiens(human)

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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