ALG14 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	ALG14
Entrez Gene ID	199857
Full Name	ALG14, UDP-N-acetylglucosaminyltransferase subunit
Synonyms	CMS15
General protein information	Preferred Names ALG14, UDP-N-acetylglucosaminyltransferase subunit Names UDP-N-acetylglucosamine transferase subunit ALG14 homolog
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 1 Map Location: 1p21.3
Summary	This gene is a member of the glycosyltransferase 1 family. The encoded protein and ALG13 are thought to be subunits of UDP-GlcNAc transferase, which catalyzes the first two committed steps in endoplasmic reticulum N-linked glycosylation. Mutations in this gene have been linked to congenital myasthenic syndrome (CMSWTA). Alternatively spliced transcript variants have been identified. [provided by RefSeq, Mar 2015].
Disorder MIM:	612866
Disorder Html:	?Myasthenic syndrome, congenital, 15, without tubular aggregates, 616227 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_144988.4	NP_659425.1	UDP-N-acetylglucosamine transferase subunit ALG14 homolog isoform 1
NM_001305242.2	NP_001292171.1	UDP-N-acetylglucosamine transferase subunit ALG14 homolog isoform 2
NM_144988.3	NP_659425.1	UDP-N-acetylglucosamine transferase subunit ALG14 homolog isoform 1
XM_005270582.3	XP_005270639.1	UDP-N-acetylglucosamine transferase subunit ALG14 homolog isoform X1
XM_011540897.2	XP_011539199.1	UDP-N-acetylglucosamine transferase subunit ALG14 homolog isoform X2
NM_001305242.1	NP_001292171.1	UDP-N-acetylglucosamine transferase subunit ALG14 homolog isoform 2
XM_005270582.4	XP_005270639.1	UDP-N-acetylglucosamine transferase subunit ALG14 homolog isoform X1

Pathways from BioSystems

Homologies

Drosophila melanogaster (fruit fly)	CG6308	NP_573031.1
Pan troglodytes (chimpanzee)	ALG14	XP_003308289.1
Rattus norvegicus (Norway rat)	Alg14	NP_001014198.1
	LOC709630	XP_001103820.1
Mus musculus (house mouse)	Alg14	NP_077140.1
Gallus gallus (chicken)	ALG14	XP_430156.3
Danio rerio (zebrafish)	alg14	NP_001006092.1
Arabidopsis thaliana (thale cress)	AT4G18230	NP_193557.2
Homo sapiens (human)	ALG14	NP_659425.1
Schizosaccharomyces pombe (fission yeast)	alg14	NP_593363.1
Canis lupus familiaris (dog)	ALG14	XP_005621948.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP003461	XP_311747.5
Xenopus tropicalis (tropical clawed frog)	alg14	XP_002933844.1

Gene Ontology
Bibliography

Related articles in PubMed

Early and lethal neurodegeneration with myasthenic and myopathic features: A new
Schorling DC, Rost S, Lefeber DJ, Brady L, M?ller CR, Korinthenberg R, Tarnopolsky M, B?nnemann CG, Rodenburg RJ, Bugiani M, Beytia M, Kr?ger M, van der Knaap M, Kirschner J
Neurology89(7)657-664(2017 Aug)

Congenital myasthenic syndromes due to mutations in ALG2 and ALG14.
Cossins J, Belaya K, Hicks D, Salih MA, Finlayson S, Carboni N, Liu WW, Maxwell S, Zoltowska K, Farsani GT, Laval S, Seidhamed MZ, , Donnelly P, Bentley D, McGowan SJ, M?ller J, Palace J, Lochm?ller H, Beeson D
Brain : a journal of neurology136(Pt 3)944-56(2013 Mar)

Membrane topology of the Alg14 endoplasmic reticulum UDP-GlcNAc transferase subunit.
Averbeck N, Keppler-Ross S, Dean N
The Journal of biological chemistry282(40)29081-8(2007 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

New ALG14 congenital disorder of glycosylation with early and lethal neurodegeneration with myasthenic and myopathic features.
Title: Early and lethal neurodegeneration with myasthenic and myopathic features: A new

We identify ALG14 and ALG2 as novel genes in which mutations cause a congenital myasthenic syndrome
Title: Congenital myasthenic syndromes due to mutations in ALG2 and ALG14.

ALG13 and ALG14 form a functional endoplasmic reticulum UDP-N-acetylglucosamine transferase
Title: Alg14 recruits Alg13 to the cytoplasmic face of the endoplasmic reticulum to form a novel bipartite UDP-N-acetylglucosamine transferase required for the second step of N-linked glycosylation.

The following ALG14 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ALG14 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu16435	NM_144988.4 Latest version!	Homo sapiens ALG14 UDP-N-acetylglucosaminyltransferase subunit (ALG14), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu77587	NM_001305242.2 Latest version!	Homo sapiens ALG14 UDP-N-acetylglucosaminyltransferase subunit (ALG14), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OHu33113	XM_005270582.4 Latest version!	Homo sapiens ALG14 UDP-N-acetylglucosaminyltransferase subunit (ALG14), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OHu77586	XM_011540897.2 Latest version!	Homo sapiens ALG14 UDP-N-acetylglucosaminyltransferase subunit (ALG14), transcript variant X3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
View Old Accession Versions >>
OHu16435	NM_144988.3	Homo sapiens ALG14, UDP-N-acetylglucosaminyltransferase subunit (ALG14), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu77587	NM_001305242.1	Homo sapiens ALG14 UDP-N-acetylglucosaminyltransferase subunit (ALG14), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OHu33113	XM_005270582.3	Homo sapiens ALG14, UDP-N-acetylglucosaminyltransferase subunit (ALG14), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
Hide Old Accession Versions >>

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***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

ALG14 ( NM_144988.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_659425.1 Homo sapiens ALG14 UDP-N-acetylglucosaminyltransferase subunit (ALG14), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu16435
Clone ID Related Accession (Same CDS sequence)	NM_144988.4 , NM_144988.3
Accession Version	NM_144988.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 651bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-18
Organism	Homo sapiens(human)
Product	UDP-N-acetylglucosamine transferase subunit ALG14 homolog isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK289395.1 and AC105942.2. This sequence is a reference standard in the RefSeqGene project. On Nov 22, 2018 this sequence version replaced NM_144988.3. Transcript Variant: This variant (1) encodes the longer isoform (1). ##Evidence-Data-START## Transcript exon combination :: AK289395.1, SRR3476690.303093.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2153932 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000370205.6/ ENSP00000359224.4 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGTGTGCG TTCTCGTTCT AGCTGCGGCC GCAGGAGCTG TGGCGGTTTT CCTAATCCTG 
CGAATATGGG TAGTGCTTCG TTCCATGGAC GTTACGCCCC GGGAGTCTCT CAGTATCTTG 
GTAGTGGCTG GGTCCGGTGG GCATACCACT GAGATCCTGA GGCTGCTTGG GAGCTTGTCC 
AATGCCTACT CACCTAGACA TTATGTCATT GCTGACACTG ATGAAATGAG TGCCAATAAA 
ATAAATTCTT TTGAACTAGA TCGAGCTGAT AGAGACCCTA GTAACATGTA TACCAAATAC 
TACATTCACC GAATTCCAAG AAGCCGGGAG GTTCAGCAGT CCTGGCCCTC CACCGTTTTC 
ACCACCTTGC ACTCCATGTG GCTCTCCTTT CCCCTAATTC ACAGGGTGAA GCCAGATTTG 
GTGTTGTGTA ACGGACCAGG AACATGTGTT CCTATCTGTG TATCTGCCCT TCTCCTTGGG 
ATACTAGGAA TAAAGAAAGT GATCATTGTC TACGTTGAAA GCATCTGCCG TGTAGAAACG 
TTATCCATGT CCGGAAAGAT TCTGTTTCAT CTCTCAGATT ACTTCATTGT TCAGTGGCCG 
GCTCTGAAAG AAAAGTATCC CAAATCGGTG TACCTTGGGC GAATTGTTTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_659425.1
CDS	54..704
Translation	MVCVLVLAAAAGAVAVFLILRIWVVLRSMDVTPRESLSILVVAGSGGHTTEILRLLGSLSNAYSPRHYVIADTDEMSANKINSFELDRADRDPSNMYTKYYIHRIPRSREVQQSWPSTVFTTLHSMWLSFPLIHRVKPDLVLCNGPGTCVPICVSALLLGILGIKKVIIVYVESICRVETLSMSGKILFHLSDYFIVQWPALKEKYPKSVYLGRIV

Target ORF information:

RefSeq Version	NM_144988.4
Organism	Homo sapiens(human)
Definition	Homo sapiens ALG14 UDP-N-acetylglucosaminyltransferase subunit (ALG14), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_144988.4

ORF Insert Sequence:

ATGGTGTGCG TTCTCGTTCT AGCTGCGGCC GCAGGAGCTG TGGCGGTTTT CCTAATCCTG 
CGAATATGGG TAGTGCTTCG TTCCATGGAC GTTACGCCCC GGGAGTCTCT CAGTATCTTG 
GTAGTGGCTG GGTCCGGTGG GCATACCACT GAGATCCTGA GGCTGCTTGG GAGCTTGTCC 
AATGCCTACT CACCTAGACA TTATGTCATT GCTGACACTG ATGAAATGAG TGCCAATAAA 
ATAAATTCTT TTGAACTAGA TCGAGCTGAT AGAGACCCTA GTAACATGTA TACCAAATAC 
TACATTCACC GAATTCCAAG AAGCCGGGAG GTTCAGCAGT CCTGGCCCTC CACCGTTTTC 
ACCACCTTGC ACTCCATGTG GCTCTCCTTT CCCCTAATTC ACAGGGTGAA GCCAGATTTG 
GTGTTGTGTA ACGGACCAGG AACATGTGTT CCTATCTGTG TATCTGCCCT TCTCCTTGGG 
ATACTAGGAA TAAAGAAAGT GATCATTGTC TACGTTGAAA GCATCTGCCG TGTAGAAACG 
TTATCCATGT CCGGAAAGAT TCTGTTTCAT CTCTCAGATT ACTTCATTGT TCAGTGGCCG 
GCTCTGAAAG AAAAGTATCC CAAATCGGTG TACCTTGGGC GAATTGTTTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ALG14 ( NM_144988.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_659425.1 Homo sapiens ALG14, UDP-N-acetylglucosaminyltransferase subunit (ALG14), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu16435
Clone ID Related Accession (Same CDS sequence)	NM_144988.4 , NM_144988.3
Accession Version	NM_144988.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 651bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-05
Organism	Homo sapiens(human)
Product	UDP-N-acetylglucosamine transferase subunit ALG14 homolog isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK289395.1. This sequence is a reference standard in the RefSeqGene project. On Aug 27, 2008 this sequence version replaced NM_144988.2. Transcript Variant: This variant (1) encodes the longer isoform (1). ##Evidence-Data-START## Transcript exon combination :: AK289395.1, SRR1163657.279427.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2153932 [ECO:0000348] ##Evidence-Data-END##

ATGGTGTGCG TTCTCGTTCT AGCTGCGGCC GCAGGAGCTG TGGCGGTTTT CCTAATCCTG 
CGAATATGGG TAGTGCTTCG TTCCATGGAC GTTACGCCCC GGGAGTCTCT CAGTATCTTG 
GTAGTGGCTG GGTCCGGTGG GCATACCACT GAGATCCTGA GGCTGCTTGG GAGCTTGTCC 
AATGCCTACT CACCTAGACA TTATGTCATT GCTGACACTG ATGAAATGAG TGCCAATAAA 
ATAAATTCTT TTGAACTAGA TCGAGCTGAT AGAGACCCTA GTAACATGTA TACCAAATAC 
TACATTCACC GAATTCCAAG AAGCCGGGAG GTTCAGCAGT CCTGGCCCTC CACCGTTTTC 
ACCACCTTGC ACTCCATGTG GCTCTCCTTT CCCCTAATTC ACAGGGTGAA GCCAGATTTG 
GTGTTGTGTA ACGGACCAGG AACATGTGTT CCTATCTGTG TATCTGCCCT TCTCCTTGGG 
ATACTAGGAA TAAAGAAAGT GATCATTGTC TACGTTGAAA GCATCTGCCG TGTAGAAACG 
TTATCCATGT CCGGAAAGAT TCTGTTTCAT CTCTCAGATT ACTTCATTGT TCAGTGGCCG 
GCTCTGAAAG AAAAGTATCC CAAATCGGTG TACCTTGGGC GAATTGTTTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_659425.1
CDS	54..704
Translation	MVCVLVLAAAAGAVAVFLILRIWVVLRSMDVTPRESLSILVVAGSGGHTTEILRLLGSLSNAYSPRHYVIADTDEMSANKINSFELDRADRDPSNMYTKYYIHRIPRSREVQQSWPSTVFTTLHSMWLSFPLIHRVKPDLVLCNGPGTCVPICVSALLLGILGIKKVIIVYVESICRVETLSMSGKILFHLSDYFIVQWPALKEKYPKSVYLGRIV

Target ORF information:

RefSeq Version	NM_144988.3
Organism	Homo sapiens(human)
Definition	Homo sapiens ALG14, UDP-N-acetylglucosaminyltransferase subunit (ALG14), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_144988.3

ORF Insert Sequence:

ATGGTGTGCG TTCTCGTTCT AGCTGCGGCC GCAGGAGCTG TGGCGGTTTT CCTAATCCTG 
CGAATATGGG TAGTGCTTCG TTCCATGGAC GTTACGCCCC GGGAGTCTCT CAGTATCTTG 
GTAGTGGCTG GGTCCGGTGG GCATACCACT GAGATCCTGA GGCTGCTTGG GAGCTTGTCC 
AATGCCTACT CACCTAGACA TTATGTCATT GCTGACACTG ATGAAATGAG TGCCAATAAA 
ATAAATTCTT TTGAACTAGA TCGAGCTGAT AGAGACCCTA GTAACATGTA TACCAAATAC 
TACATTCACC GAATTCCAAG AAGCCGGGAG GTTCAGCAGT CCTGGCCCTC CACCGTTTTC 
ACCACCTTGC ACTCCATGTG GCTCTCCTTT CCCCTAATTC ACAGGGTGAA GCCAGATTTG 
GTGTTGTGTA ACGGACCAGG AACATGTGTT CCTATCTGTG TATCTGCCCT TCTCCTTGGG 
ATACTAGGAA TAAAGAAAGT GATCATTGTC TACGTTGAAA GCATCTGCCG TGTAGAAACG 
TTATCCATGT CCGGAAAGAT TCTGTTTCAT CTCTCAGATT ACTTCATTGT TCAGTGGCCG 
GCTCTGAAAG AAAAGTATCC CAAATCGGTG TACCTTGGGC GAATTGTTTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ALG14 ( NM_001305242.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001292171.1 Homo sapiens ALG14 UDP-N-acetylglucosaminyltransferase subunit (ALG14), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu77587
Clone ID Related Accession (Same CDS sequence)	NM_001305242.2 , NM_001305242.1
Accession Version	NM_001305242.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 468bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-18
Organism	Homo sapiens(human)
Product	UDP-N-acetylglucosamine transferase subunit ALG14 homolog isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK289395.1, AW242346.1 and AC105942.2. On May 31, 2019 this sequence version replaced NM_001305242.1. Transcript Variant: This variant (2) contains an alternate exon in the central coding region, which results in a frameshift and an early stop codon, compared to variant 1. The encoded isoform (2) has a shorter and distinct C-terminus, compared to isoform 1. ##Evidence-Data-START## Transcript exon combination :: AW242346.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2154361, SAMN03465405 [ECO:0000348] ##Evidence-Data-END##

ATGGTGTGCG TTCTCGTTCT AGCTGCGGCC GCAGGAGCTG TGGCGGTTTT CCTAATCCTG 
CGAATATGGG TAGTGCTTCG TTCCATGGAC GTTACGCCCC GGGAGTCTCT CAGTATCTTG 
GTAGTGGCTG GGTCCGGTGG GCATACCACT GAGATCCTGA GGCTGCTTGG GAGCTTGTCC 
AATGCCTACT CACCTAGACA TTATGTCATT GCTGACACTG ATGAAATGAG TGCCAATAAA 
ATAAATTCTT TTGAACTAGA TCGAGCTGAT AGAGACCCTA GTAACATGGA CTTTTCAGTC 
GTGTGGCATT CACTAAATAA TAAAGTATAC CAAATACTAC ATTCACCGAA TTCCAAGAAG 
CCGGGAGGTT CAGCAGTCCT GGCCCTCCAC CGTTTTCACC ACCTTGCACT CCATGTGGCT 
CTCCTTTCCC CTAATTCACA GGGTGAAGCC AGATTTGGTG TTGTGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001292171.1
CDS	54..521
Translation	MVCVLVLAAAAGAVAVFLILRIWVVLRSMDVTPRESLSILVVAGSGGHTTEILRLLGSLSNAYSPRHYVIADTDEMSANKINSFELDRADRDPSNMDFSVVWHSLNNKVYQILHSPNSKKPGGSAVLALHRFHHLALHVALLSPNSQGEARFGVV

Target ORF information:

RefSeq Version	NM_001305242.2
Organism	Homo sapiens(human)
Definition	Homo sapiens ALG14 UDP-N-acetylglucosaminyltransferase subunit (ALG14), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001305242.2

ORF Insert Sequence:

ATGGTGTGCG TTCTCGTTCT AGCTGCGGCC GCAGGAGCTG TGGCGGTTTT CCTAATCCTG 
CGAATATGGG TAGTGCTTCG TTCCATGGAC GTTACGCCCC GGGAGTCTCT CAGTATCTTG 
GTAGTGGCTG GGTCCGGTGG GCATACCACT GAGATCCTGA GGCTGCTTGG GAGCTTGTCC 
AATGCCTACT CACCTAGACA TTATGTCATT GCTGACACTG ATGAAATGAG TGCCAATAAA 
ATAAATTCTT TTGAACTAGA TCGAGCTGAT AGAGACCCTA GTAACATGGA CTTTTCAGTC 
GTGTGGCATT CACTAAATAA TAAAGTATAC CAAATACTAC ATTCACCGAA TTCCAAGAAG 
CCGGGAGGTT CAGCAGTCCT GGCCCTCCAC CGTTTTCACC ACCTTGCACT CCATGTGGCT 
CTCCTTTCCC CTAATTCACA GGGTGAAGCC AGATTTGGTG TTGTGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ALG14 ( NM_001305242.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001292171.1 Homo sapiens ALG14 UDP-N-acetylglucosaminyltransferase subunit (ALG14), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu77587
Clone ID Related Accession (Same CDS sequence)	NM_001305242.2 , NM_001305242.1
Accession Version	NM_001305242.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 468bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-24
Organism	Homo sapiens(human)
Product	UDP-N-acetylglucosamine transferase subunit ALG14 homolog isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK289395.1 and AW242346.1. Transcript Variant: This variant (2) contains an alternate exon in the central coding region, which results in a frameshift and an early stop codon, compared to variant 1. The encoded isoform (2) has a shorter and distinct C-terminus, compared to isoform 1. ##Evidence-Data-START## Transcript exon combination :: AW242346.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2154361, SAMN03465405 [ECO:0000348] ##Evidence-Data-END##

ATGGTGTGCG TTCTCGTTCT AGCTGCGGCC GCAGGAGCTG TGGCGGTTTT CCTAATCCTG 
CGAATATGGG TAGTGCTTCG TTCCATGGAC GTTACGCCCC GGGAGTCTCT CAGTATCTTG 
GTAGTGGCTG GGTCCGGTGG GCATACCACT GAGATCCTGA GGCTGCTTGG GAGCTTGTCC 
AATGCCTACT CACCTAGACA TTATGTCATT GCTGACACTG ATGAAATGAG TGCCAATAAA 
ATAAATTCTT TTGAACTAGA TCGAGCTGAT AGAGACCCTA GTAACATGGA CTTTTCAGTC 
GTGTGGCATT CACTAAATAA TAAAGTATAC CAAATACTAC ATTCACCGAA TTCCAAGAAG 
CCGGGAGGTT CAGCAGTCCT GGCCCTCCAC CGTTTTCACC ACCTTGCACT CCATGTGGCT 
CTCCTTTCCC CTAATTCACA GGGTGAAGCC AGATTTGGTG TTGTGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001292171.1
CDS	54..521
Translation	MVCVLVLAAAAGAVAVFLILRIWVVLRSMDVTPRESLSILVVAGSGGHTTEILRLLGSLSNAYSPRHYVIADTDEMSANKINSFELDRADRDPSNMDFSVVWHSLNNKVYQILHSPNSKKPGGSAVLALHRFHHLALHVALLSPNSQGEARFGVV

Target ORF information:

RefSeq Version	NM_001305242.1
Organism	Homo sapiens(human)
Definition	Homo sapiens ALG14 UDP-N-acetylglucosaminyltransferase subunit (ALG14), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001305242.1

ORF Insert Sequence:

ATGGTGTGCG TTCTCGTTCT AGCTGCGGCC GCAGGAGCTG TGGCGGTTTT CCTAATCCTG 
CGAATATGGG TAGTGCTTCG TTCCATGGAC GTTACGCCCC GGGAGTCTCT CAGTATCTTG 
GTAGTGGCTG GGTCCGGTGG GCATACCACT GAGATCCTGA GGCTGCTTGG GAGCTTGTCC 
AATGCCTACT CACCTAGACA TTATGTCATT GCTGACACTG ATGAAATGAG TGCCAATAAA 
ATAAATTCTT TTGAACTAGA TCGAGCTGAT AGAGACCCTA GTAACATGGA CTTTTCAGTC 
GTGTGGCATT CACTAAATAA TAAAGTATAC CAAATACTAC ATTCACCGAA TTCCAAGAAG 
CCGGGAGGTT CAGCAGTCCT GGCCCTCCAC CGTTTTCACC ACCTTGCACT CCATGTGGCT 
CTCCTTTCCC CTAATTCACA GGGTGAAGCC AGATTTGGTG TTGTGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ALG14 ( XM_005270582.3 ) cDNA ORF clone, Homo sapiens(human) -> XP_005270639.1 Homo sapiens ALG14, UDP-N-acetylglucosaminyltransferase subunit (ALG14), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu33113
Clone ID Related Accession (Same CDS sequence)	XM_005270582.3 , XM_005270582.4
Accession Version	XM_005270582.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 468bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-05
Organism	Homo sapiens(human)
Product	UDP-N-acetylglucosamine transferase subunit ALG14 homolog isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000001.11) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_005270582.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGTGTGCG TTCTCGTTCT AGCTGCGGCC GCAGGAGCTG TGGCGGTTTT CCTAATCCTG 
CGAATATGGG TAGTGCTTCG TTCCATGGAC GTTACGCCCC GGGAGTCTCT CAGTATCTTG 
GTAGTGGCTG GGTCCGGTGG GCATACCACT GAGATCCTGA GGCTGCTTGG GAGCTTGTCC 
AATGCCTACT CACCTAGACA TTATGTCATT GCTGACACTG ATGAAATGAG TGCCAATAAA 
ATAAATTCTT TTGAACTAGA TCGAGCTGAT AGAGACCCTA GTAACATGTA TACCAAATAC 
TACATTCACC GAATTCCAAG AAGCCGGGAG GTTCAGCAGT CCTGGCCCTC CACCGTTTTC 
ACCACCTTGC ACTCCATGTG GCTCTCCTTT CCCCTAATTC ACAGGGTGAA GCCAGATTTG 
TTGCATGGTG AAATTACCAG CTGTGCCACT GACACATTGG CTGAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_005270639.1
CDS	76..543
Translation	MVCVLVLAAAAGAVAVFLILRIWVVLRSMDVTPRESLSILVVAGSGGHTTEILRLLGSLSNAYSPRHYVIADTDEMSANKINSFELDRADRDPSNMYTKYYIHRIPRSREVQQSWPSTVFTTLHSMWLSFPLIHRVKPDLLHGEITSCATDTLAE

Target ORF information:

RefSeq Version	XM_005270582.3
Organism	Homo sapiens(human)
Definition	Homo sapiens ALG14, UDP-N-acetylglucosaminyltransferase subunit (ALG14), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_005270582.3

ORF Insert Sequence:

ATGGTGTGCG TTCTCGTTCT AGCTGCGGCC GCAGGAGCTG TGGCGGTTTT CCTAATCCTG 
CGAATATGGG TAGTGCTTCG TTCCATGGAC GTTACGCCCC GGGAGTCTCT CAGTATCTTG 
GTAGTGGCTG GGTCCGGTGG GCATACCACT GAGATCCTGA GGCTGCTTGG GAGCTTGTCC 
AATGCCTACT CACCTAGACA TTATGTCATT GCTGACACTG ATGAAATGAG TGCCAATAAA 
ATAAATTCTT TTGAACTAGA TCGAGCTGAT AGAGACCCTA GTAACATGTA TACCAAATAC 
TACATTCACC GAATTCCAAG AAGCCGGGAG GTTCAGCAGT CCTGGCCCTC CACCGTTTTC 
ACCACCTTGC ACTCCATGTG GCTCTCCTTT CCCCTAATTC ACAGGGTGAA GCCAGATTTG 
TTGCATGGTG AAATTACCAG CTGTGCCACT GACACATTGG CTGAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ALG14 ( XM_005270582.4 ) cDNA ORF clone, Homo sapiens(human) -> XP_005270639.1 Homo sapiens ALG14 UDP-N-acetylglucosaminyltransferase subunit (ALG14), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu33113
Clone ID Related Accession (Same CDS sequence)	XM_005270582.3 , XM_005270582.4
Accession Version	XM_005270582.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 468bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	UDP-N-acetylglucosamine transferase subunit ALG14 homolog isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000001.11) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_005270582.3. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGTGTGCG TTCTCGTTCT AGCTGCGGCC GCAGGAGCTG TGGCGGTTTT CCTAATCCTG 
CGAATATGGG TAGTGCTTCG TTCCATGGAC GTTACGCCCC GGGAGTCTCT CAGTATCTTG 
GTAGTGGCTG GGTCCGGTGG GCATACCACT GAGATCCTGA GGCTGCTTGG GAGCTTGTCC 
AATGCCTACT CACCTAGACA TTATGTCATT GCTGACACTG ATGAAATGAG TGCCAATAAA 
ATAAATTCTT TTGAACTAGA TCGAGCTGAT AGAGACCCTA GTAACATGTA TACCAAATAC 
TACATTCACC GAATTCCAAG AAGCCGGGAG GTTCAGCAGT CCTGGCCCTC CACCGTTTTC 
ACCACCTTGC ACTCCATGTG GCTCTCCTTT CCCCTAATTC ACAGGGTGAA GCCAGATTTG 
TTGCATGGTG AAATTACCAG CTGTGCCACT GACACATTGG CTGAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_005270639.1
CDS	77..544
Translation	MVCVLVLAAAAGAVAVFLILRIWVVLRSMDVTPRESLSILVVAGSGGHTTEILRLLGSLSNAYSPRHYVIADTDEMSANKINSFELDRADRDPSNMYTKYYIHRIPRSREVQQSWPSTVFTTLHSMWLSFPLIHRVKPDLLHGEITSCATDTLAE

Target ORF information:

RefSeq Version	XM_005270582.4
Organism	Homo sapiens(human)
Definition	Homo sapiens ALG14 UDP-N-acetylglucosaminyltransferase subunit (ALG14), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_005270582.4

ORF Insert Sequence:

ATGGTGTGCG TTCTCGTTCT AGCTGCGGCC GCAGGAGCTG TGGCGGTTTT CCTAATCCTG 
CGAATATGGG TAGTGCTTCG TTCCATGGAC GTTACGCCCC GGGAGTCTCT CAGTATCTTG 
GTAGTGGCTG GGTCCGGTGG GCATACCACT GAGATCCTGA GGCTGCTTGG GAGCTTGTCC 
AATGCCTACT CACCTAGACA TTATGTCATT GCTGACACTG ATGAAATGAG TGCCAATAAA 
ATAAATTCTT TTGAACTAGA TCGAGCTGAT AGAGACCCTA GTAACATGTA TACCAAATAC 
TACATTCACC GAATTCCAAG AAGCCGGGAG GTTCAGCAGT CCTGGCCCTC CACCGTTTTC 
ACCACCTTGC ACTCCATGTG GCTCTCCTTT CCCCTAATTC ACAGGGTGAA GCCAGATTTG 
TTGCATGGTG AAATTACCAG CTGTGCCACT GACACATTGG CTGAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ALG14 ( XM_011540897.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_011539199.1 Homo sapiens ALG14 UDP-N-acetylglucosaminyltransferase subunit (ALG14), transcript variant X3, mRNA.

Price & Availability↑

CloneID	OHu77586
Clone ID Related Accession (Same CDS sequence)	XM_011540897.2
Accession Version	XM_011540897.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 465bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	UDP-N-acetylglucosamine transferase subunit ALG14 homolog isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000001.11) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011540897.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGTGTGCG TTCTCGTTCT AGCTGCGGCC GCAGGAGCTG TGGCGGTTTT CCTAATCCTG 
CGAATATGGG TAGTGCTTCG TTCCATGGAC GTTACGCCCC GGGAGTCTCT CAGTATCTTG 
GTAGTGGCTG GGTCCGGTGG GCATACCACT GAGATCCTGA GGCTGCTTGG GAGCTTGTCC 
AATGCCTACT CACCTAGACA TTATGTCATT GCTGACACTG ATGAAATGAG TGCCAATAAA 
ATAAATTCTT TTGAACTAGA TCGAGCTGAT AGAGACCCTA GTAACATGTA TACCAAATAC 
TACATTCACC GAATTCCAAG AAGCCGGGAG GTTCAGCAGT CCTGGCCCTC CACCGTTTTC 
ACCACCTTGC ACTCCATGTG GCTCTCCTTT CCCCTAATTC ACAGGGTGAA GCCAGATTTG 
GTCCACAGAG CAGTCAGAGA AGAGCAACAC ATGCCTGTCC GATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011539199.1
CDS	76..540
Translation	MVCVLVLAAAAGAVAVFLILRIWVVLRSMDVTPRESLSILVVAGSGGHTTEILRLLGSLSNAYSPRHYVIADTDEMSANKINSFELDRADRDPSNMYTKYYIHRIPRSREVQQSWPSTVFTTLHSMWLSFPLIHRVKPDLVHRAVREEQHMPVR

Target ORF information:

RefSeq Version	XM_011540897.2
Organism	Homo sapiens(human)
Definition	Homo sapiens ALG14 UDP-N-acetylglucosaminyltransferase subunit (ALG14), transcript variant X3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011540897.2

ORF Insert Sequence:

ATGGTGTGCG TTCTCGTTCT AGCTGCGGCC GCAGGAGCTG TGGCGGTTTT CCTAATCCTG 
CGAATATGGG TAGTGCTTCG TTCCATGGAC GTTACGCCCC GGGAGTCTCT CAGTATCTTG 
GTAGTGGCTG GGTCCGGTGG GCATACCACT GAGATCCTGA GGCTGCTTGG GAGCTTGTCC 
AATGCCTACT CACCTAGACA TTATGTCATT GCTGACACTG ATGAAATGAG TGCCAATAAA 
ATAAATTCTT TTGAACTAGA TCGAGCTGAT AGAGACCCTA GTAACATGTA TACCAAATAC 
TACATTCACC GAATTCCAAG AAGCCGGGAG GTTCAGCAGT CCTGGCCCTC CACCGTTTTC 
ACCACCTTGC ACTCCATGTG GCTCTCCTTT CCCCTAATTC ACAGGGTGAA GCCAGATTTG 
GTCCACAGAG CAGTCAGAGA AGAGCAACAC ATGCCTGTCC GATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Early and lethal neurodegeneration with myasthenic and myopathic features: A new
Neurology89(7)657-664(2017 Aug)
Schorling DC,Rost S,Lefeber DJ,Brady L,M?ller CR,Korinthenberg R,Tarnopolsky M,B?nnemann CG,Rodenburg RJ,Bugiani M,Beytia M,Kr?ger M,van der Knaap M,Kirschner J

Congenital myasthenic syndromes due to mutations in ALG2 and ALG14.
Brain : a journal of neurology136(Pt 3)944-56(2013 Mar)
Cossins J,Belaya K,Hicks D,Salih MA,Finlayson S,Carboni N,Liu WW,Maxwell S,Zoltowska K,Farsani GT,Laval S,Seidhamed MZ,,Donnelly P,Bentley D,McGowan SJ,M?ller J,Palace J,Lochm?ller H,Beeson D

Membrane topology of the Alg14 endoplasmic reticulum UDP-GlcNAc transferase subunit.
The Journal of biological chemistry282(40)29081-8(2007 Oct)
Averbeck N,Keppler-Ross S,Dean N

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ALG14 cDNA ORF clone, Homo sapiens(human)

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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