PRIMA1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	PRIMA1
Entrez Gene ID	145270
Full Name	proline rich membrane anchor 1
Synonyms	PRIMA
General protein information	Preferred Names proline rich membrane anchor 1 Names proline-rich membrane anchor 1 acetylcholinesterase membrane anchor precursor PRiMA
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 14 Map Location: 14q32.12
Summary	The product of this gene functions to organize acetylcholinesterase (AChE) into tetramers, and to anchor AChE at neural cell membranes. [provided by RefSeq, Nov 2008].
Disorder MIM:	613851

mRNA and Protein(s)

mRNA	Protein	Name
XM_011536456.2	XP_011534758.1	proline-rich membrane anchor 1 isoform X1
NM_178013.4	NP_821092.1	proline-rich membrane anchor 1 precursor
NM_178013.3	NP_821092.1	proline-rich membrane anchor 1 precursor
XM_024449482.1	XP_024305250.1	proline-rich membrane anchor 1 isoform X2

Pathways from BioSystems

Homologies

Xenopus tropicalis (tropical clawed frog)	prima1	XP_002933274.1
Bos taurus (cattle)	PRIMA1	NP_001070955.1
Pan troglodytes (chimpanzee)	PRIMA1	XP_003952611.1
Mus musculus (house mouse)	Prima1	NP_579942.2
Gallus gallus (chicken)	PRIMA1	NP_001138964.1
Homo sapiens (human)	PRIMA1	NP_821092.1
Canis lupus familiaris (dog)	PRIMA1	XP_854468.1
Rattus norvegicus (Norway rat)	Prima1	NP_001102191.2

Gene Ontology
Bibliography

Related articles in PubMed

Colorectal adenoma and cancer detection based on altered methylation pattern of SFRP1, SFRP2, SDC2, and PRIMA1 in plasma samples.
Bart?k BK, Kalm?r A, P?terfia B, Patai ?V, Galamb O, Valcz G, Spis?k S, Wichmann B, Nagy ZB, T?th K, Tulassay Z, Igaz P, Moln?r B
Epigenetics12(9)751-763(2017 Sep)

PRIMA-1 targets the vulnerability of multiple myeloma of deregulated protein homeostasis through the perturbation of ER stress via p73 demethylation.
Teoh PJ, Bi C, Sintosebastian C, Tay LS, Fonseca R, Chng WJ
Oncotarget7(38)61806-61819(2016 Sep)

Silencing of CD24 Enhances the PRIMA-1-Induced Restoration of Mutant p53 in Prostate Cancer Cells.
Zhang W, Yi B, Wang C, Chen D, Bae S, Wei S, Guo RJ, Lu C, Nguyen LL, Yang WH, Lillard JW, Zhang X, Wang L, Liu R
Clinical cancer research : an official journal of the American Association for Cancer Research22(10)2545-54(2016 May)

Aberrant DNA Methylation of rDNA and PRIMA1 in Borderline Personality Disorder.
Teschler S, Gotthardt J, Dammann G, Dammann RH
International journal of molecular sciences17(1)(2016 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Silencing of CD24 enhanced restoration of PRIMA-1-induced mutant p53 in endogenous TP53(P223L/V274F) DU145 cells.
Title: Silencing of CD24 Enhances the PRIMA-1-Induced Restoration of Mutant p53 in Prostate Cancer Cells.

The results suggest that aberrant methylation of rDNA and PRIMA1 is associated with the pathogenesis of Borderline Personality Disorder.
Title: Aberrant DNA Methylation of rDNA and PRIMA1 in Borderline Personality Disorder.

Hypermethylation of the selected markers (MAL, PRIMA1, PTGDR and SFRP1) can result in reduced gene expression and may contribute to the formation of colorectal cancer.
Title: DNA hypermethylation and decreased mRNA expression of MAL, PRIMA1, PTGDR and SFRP1 in colorectal adenoma and cancer.

The autophagic potential of PRIMA-1 could be modulated in a different way by the presence of wild type or mutant p53.
Title: PRIMA-1 induces autophagy in cancer cells carrying mutant or wild type p53.

By using site-directed mutagenesis, the asparagine-43 was identified to be the N-linked glycosylation site of PRiMA. Abolishing glycosylation on mouse PRiMA appeared not to affect its assembly with AChE(T).
Title: N-linked glycosylation of proline-rich membrane anchor (PRiMA) is not required for assembly and trafficking of globular tetrameric acetylcholinesterase.

The following PRIMA1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PRIMA1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu103862	XM_024449482.1 Latest version!	Homo sapiens proline rich membrane anchor 1 (PRIMA1), transcript variant X3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
OHu18069	NM_178013.4 Latest version!	Homo sapiens proline rich membrane anchor 1 (PRIMA1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$69.30 $99.00
OHu18069	XM_011536456.2 Latest version!	Homo sapiens proline rich membrane anchor 1 (PRIMA1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$69.30 $99.00
View Old Accession Versions >>
OHu18069	NM_178013.3	Homo sapiens proline rich membrane anchor 1 (PRIMA1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

PRIMA1 ( XM_024449482.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_024305250.1 Homo sapiens proline rich membrane anchor 1 (PRIMA1), transcript variant X3, mRNA.

Price & Availability↑

CloneID	OHu103862
Clone ID Related Accession (Same CDS sequence)	XM_024449482.1
Accession Version	XM_024449482.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 372bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	proline-rich membrane anchor 1 isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000014.9) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCTCCTCC GGGACTTGGT GCTGCGCCGT GGCTGCTGCT GGTCCTCGCT GCTGCTGCAC 
TGCGCGCTCC ACCCGCTCTG GGGCTTCGTG CAGGTGACGC ATGGTGAGCC CCAGAAGTCC 
TGCTCCAAAG TGACTGACAG CTGCCGACAC GTCTGCCAGT GCCGGCCCCC TCCCCCGCTG 
CCCCCGCCGC CCCCACCCCC GCCACCTCCC AGACTCCTCT CCGCCCCAGC TCCCAACTCT 
ACCTCTTGCC CCACTGAGGA AAGCTGGTGG TCGGGGCTGG TGATCATCAT TGCCGTATGC 
TGTGCCTCCC TGGTGTTTCT GACTGTGCTT GTCATCATTT GCTACAAAGC CATAAAAAGC 
CTCGAGTCCT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_024305250.1
CDS	109..480
Translation	MLLRDLVLRRGCCWSSLLLHCALHPLWGFVQVTHGEPQKSCSKVTDSCRHVCQCRPPPPLPPPPPPPPPPRLLSAPAPNSTSCPTEESWWSGLVIIIAVCCASLVFLTVLVIICYKAIKSLES

Target ORF information:

RefSeq Version	XM_024449482.1
Organism	Homo sapiens(human)
Definition	Homo sapiens proline rich membrane anchor 1 (PRIMA1), transcript variant X3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_024449482.1

ORF Insert Sequence:

ATGCTCCTCC GGGACTTGGT GCTGCGCCGT GGCTGCTGCT GGTCCTCGCT GCTGCTGCAC 
TGCGCGCTCC ACCCGCTCTG GGGCTTCGTG CAGGTGACGC ATGGTGAGCC CCAGAAGTCC 
TGCTCCAAAG TGACTGACAG CTGCCGACAC GTCTGCCAGT GCCGGCCCCC TCCCCCGCTG 
CCCCCGCCGC CCCCACCCCC GCCACCTCCC AGACTCCTCT CCGCCCCAGC TCCCAACTCT 
ACCTCTTGCC CCACTGAGGA AAGCTGGTGG TCGGGGCTGG TGATCATCAT TGCCGTATGC 
TGTGCCTCCC TGGTGTTTCT GACTGTGCTT GTCATCATTT GCTACAAAGC CATAAAAAGC 
CTCGAGTCCT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PRIMA1 ( NM_178013.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_821092.1 Homo sapiens proline rich membrane anchor 1 (PRIMA1), mRNA.

Price & Availability↑

CloneID	OHu18069
Clone ID Related Accession (Same CDS sequence)	XM_011536456.2 , NM_178013.4 , NM_178013.3
Accession Version	NM_178013.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 462bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Homo sapiens(human)
Product	proline-rich membrane anchor 1 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL132642.4, AY225516.1, AL157858.5 and BU726715.1. This sequence is a reference standard in the RefSeqGene project. On Nov 22, 2018 this sequence version replaced NM_178013.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AY225516.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA2142348 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000393140.6/ ENSP00000376848.1 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGCTCCTCC GGGACTTGGT GCTGCGCCGT GGCTGCTGCT GGTCCTCGCT GCTGCTGCAC 
TGCGCGCTCC ACCCGCTCTG GGGCTTCGTG CAGGTGACGC ATGGTGAGCC CCAGAAGTCC 
TGCTCCAAAG TGACTGACAG CTGCCGACAC GTCTGCCAGT GCCGGCCCCC TCCCCCGCTG 
CCCCCGCCGC CCCCACCCCC GCCACCTCCC AGACTCCTCT CCGCCCCAGC TCCCAACTCT 
ACCTCTTGCC CCACTGAGGA AAGCTGGTGG TCGGGGCTGG TGATCATCAT TGCCGTATGC 
TGTGCCTCCC TGGTGTTTCT GACTGTGCTT GTCATCATTT GCTACAAAGC CATAAAAAGG 
AAACCACTGA GAAAAGACGA AAATGGCACC AGCGTTGCTG AGTATCCCAT GAGTGCTTCG 
CAGAGCAACA AAGGAGTAGA CGTGAACAAC GCAGTGGTGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_821092.1
CDS	108..569
Translation	MLLRDLVLRRGCCWSSLLLHCALHPLWGFVQVTHGEPQKSCSKVTDSCRHVCQCRPPPPLPPPPPPPPPPRLLSAPAPNSTSCPTEESWWSGLVIIIAVCCASLVFLTVLVIICYKAIKRKPLRKDENGTSVAEYPMSASQSNKGVDVNNAVV

Target ORF information:

RefSeq Version	NM_178013.4
Organism	Homo sapiens(human)
Definition	Homo sapiens proline rich membrane anchor 1 (PRIMA1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_178013.4

ORF Insert Sequence:

ATGCTCCTCC GGGACTTGGT GCTGCGCCGT GGCTGCTGCT GGTCCTCGCT GCTGCTGCAC 
TGCGCGCTCC ACCCGCTCTG GGGCTTCGTG CAGGTGACGC ATGGTGAGCC CCAGAAGTCC 
TGCTCCAAAG TGACTGACAG CTGCCGACAC GTCTGCCAGT GCCGGCCCCC TCCCCCGCTG 
CCCCCGCCGC CCCCACCCCC GCCACCTCCC AGACTCCTCT CCGCCCCAGC TCCCAACTCT 
ACCTCTTGCC CCACTGAGGA AAGCTGGTGG TCGGGGCTGG TGATCATCAT TGCCGTATGC 
TGTGCCTCCC TGGTGTTTCT GACTGTGCTT GTCATCATTT GCTACAAAGC CATAAAAAGG 
AAACCACTGA GAAAAGACGA AAATGGCACC AGCGTTGCTG AGTATCCCAT GAGTGCTTCG 
CAGAGCAACA AAGGAGTAGA CGTGAACAAC GCAGTGGTGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PRIMA1 ( NM_178013.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_821092.1 Homo sapiens proline rich membrane anchor 1 (PRIMA1), mRNA.

Price & Availability↑

CloneID	OHu18069
Clone ID Related Accession (Same CDS sequence)	XM_011536456.2 , NM_178013.4 , NM_178013.3
Accession Version	NM_178013.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 462bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	proline-rich membrane anchor 1 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AY225516.1, AL132642.4, AL157858.5 and BU726715.1. This sequence is a reference standard in the RefSeqGene project. On Nov 26, 2008 this sequence version replaced NM_178013.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AY225516.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA2142348 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCTCCTCC GGGACTTGGT GCTGCGCCGT GGCTGCTGCT GGTCCTCGCT GCTGCTGCAC 
TGCGCGCTCC ACCCGCTCTG GGGCTTCGTG CAGGTGACGC ATGGTGAGCC CCAGAAGTCC 
TGCTCCAAAG TGACTGACAG CTGCCGACAC GTCTGCCAGT GCCGGCCCCC TCCCCCGCTG 
CCCCCGCCGC CCCCACCCCC GCCACCTCCC AGACTCCTCT CCGCCCCAGC TCCCAACTCT 
ACCTCTTGCC CCACTGAGGA AAGCTGGTGG TCGGGGCTGG TGATCATCAT TGCCGTATGC 
TGTGCCTCCC TGGTGTTTCT GACTGTGCTT GTCATCATTT GCTACAAAGC CATAAAAAGG 
AAACCACTGA GAAAAGACGA AAATGGCACC AGCGTTGCTG AGTATCCCAT GAGTGCTTCG 
CAGAGCAACA AAGGAGTAGA CGTGAACAAC GCAGTGGTGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_821092.1
CDS	43..504
Translation	MLLRDLVLRRGCCWSSLLLHCALHPLWGFVQVTHGEPQKSCSKVTDSCRHVCQCRPPPPLPPPPPPPPPPRLLSAPAPNSTSCPTEESWWSGLVIIIAVCCASLVFLTVLVIICYKAIKRKPLRKDENGTSVAEYPMSASQSNKGVDVNNAVV

Target ORF information:

RefSeq Version	NM_178013.3
Organism	Homo sapiens(human)
Definition	Homo sapiens proline rich membrane anchor 1 (PRIMA1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_178013.3

ORF Insert Sequence:

ATGCTCCTCC GGGACTTGGT GCTGCGCCGT GGCTGCTGCT GGTCCTCGCT GCTGCTGCAC 
TGCGCGCTCC ACCCGCTCTG GGGCTTCGTG CAGGTGACGC ATGGTGAGCC CCAGAAGTCC 
TGCTCCAAAG TGACTGACAG CTGCCGACAC GTCTGCCAGT GCCGGCCCCC TCCCCCGCTG 
CCCCCGCCGC CCCCACCCCC GCCACCTCCC AGACTCCTCT CCGCCCCAGC TCCCAACTCT 
ACCTCTTGCC CCACTGAGGA AAGCTGGTGG TCGGGGCTGG TGATCATCAT TGCCGTATGC 
TGTGCCTCCC TGGTGTTTCT GACTGTGCTT GTCATCATTT GCTACAAAGC CATAAAAAGG 
AAACCACTGA GAAAAGACGA AAATGGCACC AGCGTTGCTG AGTATCCCAT GAGTGCTTCG 
CAGAGCAACA AAGGAGTAGA CGTGAACAAC GCAGTGGTGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PRIMA1 ( XM_011536456.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_011534758.1 Homo sapiens proline rich membrane anchor 1 (PRIMA1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu18069
Clone ID Related Accession (Same CDS sequence)	XM_011536456.2 , NM_178013.4 , NM_178013.3
Accession Version	XM_011536456.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 462bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	proline-rich membrane anchor 1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000014.9) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011536456.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCTCCTCC GGGACTTGGT GCTGCGCCGT GGCTGCTGCT GGTCCTCGCT GCTGCTGCAC 
TGCGCGCTCC ACCCGCTCTG GGGCTTCGTG CAGGTGACGC ATGGTGAGCC CCAGAAGTCC 
TGCTCCAAAG TGACTGACAG CTGCCGACAC GTCTGCCAGT GCCGGCCCCC TCCCCCGCTG 
CCCCCGCCGC CCCCACCCCC GCCACCTCCC AGACTCCTCT CCGCCCCAGC TCCCAACTCT 
ACCTCTTGCC CCACTGAGGA AAGCTGGTGG TCGGGGCTGG TGATCATCAT TGCCGTATGC 
TGTGCCTCCC TGGTGTTTCT GACTGTGCTT GTCATCATTT GCTACAAAGC CATAAAAAGG 
AAACCACTGA GAAAAGACGA AAATGGCACC AGCGTTGCTG AGTATCCCAT GAGTGCTTCG 
CAGAGCAACA AAGGAGTAGA CGTGAACAAC GCAGTGGTGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011534758.1
CDS	497..958
Translation	MLLRDLVLRRGCCWSSLLLHCALHPLWGFVQVTHGEPQKSCSKVTDSCRHVCQCRPPPPLPPPPPPPPPPRLLSAPAPNSTSCPTEESWWSGLVIIIAVCCASLVFLTVLVIICYKAIKRKPLRKDENGTSVAEYPMSASQSNKGVDVNNAVV

Target ORF information:

RefSeq Version	XM_011536456.2
Organism	Homo sapiens(human)
Definition	Homo sapiens proline rich membrane anchor 1 (PRIMA1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011536456.2

ORF Insert Sequence:

ATGCTCCTCC GGGACTTGGT GCTGCGCCGT GGCTGCTGCT GGTCCTCGCT GCTGCTGCAC 
TGCGCGCTCC ACCCGCTCTG GGGCTTCGTG CAGGTGACGC ATGGTGAGCC CCAGAAGTCC 
TGCTCCAAAG TGACTGACAG CTGCCGACAC GTCTGCCAGT GCCGGCCCCC TCCCCCGCTG 
CCCCCGCCGC CCCCACCCCC GCCACCTCCC AGACTCCTCT CCGCCCCAGC TCCCAACTCT 
ACCTCTTGCC CCACTGAGGA AAGCTGGTGG TCGGGGCTGG TGATCATCAT TGCCGTATGC 
TGTGCCTCCC TGGTGTTTCT GACTGTGCTT GTCATCATTT GCTACAAAGC CATAAAAAGG 
AAACCACTGA GAAAAGACGA AAATGGCACC AGCGTTGCTG AGTATCCCAT GAGTGCTTCG 
CAGAGCAACA AAGGAGTAGA CGTGAACAAC GCAGTGGTGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Colorectal adenoma and cancer detection based on altered methylation pattern of SFRP1, SFRP2, SDC2, and PRIMA1 in plasma samples.
Epigenetics12(9)751-763(2017 Sep)
Bart?k BK,Kalm?r A,P?terfia B,Patai ?V,Galamb O,Valcz G,Spis?k S,Wichmann B,Nagy ZB,T?th K,Tulassay Z,Igaz P,Moln?r B

PRIMA-1 targets the vulnerability of multiple myeloma of deregulated protein homeostasis through the perturbation of ER stress via p73 demethylation.
Oncotarget7(38)61806-61819(2016 Sep)
Teoh PJ,Bi C,Sintosebastian C,Tay LS,Fonseca R,Chng WJ

Silencing of CD24 Enhances the PRIMA-1-Induced Restoration of Mutant p53 in Prostate Cancer Cells.
Clinical cancer research : an official journal of the American Association for Cancer Research22(10)2545-54(2016 May)
Zhang W,Yi B,Wang C,Chen D,Bae S,Wei S,Guo RJ,Lu C,Nguyen LL,Yang WH,Lillard JW,Zhang X,Wang L,Liu R

Aberrant DNA Methylation of rDNA and PRIMA1 in Borderline Personality Disorder.
International journal of molecular sciences17(1)(2016 Jan)
Teschler S,Gotthardt J,Dammann G,Dammann RH

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PRIMA1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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Services & Products

見積依頼

Eメール

電話

FAX

オンラインフォーム