COX6A2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	COX6A2
Entrez Gene ID	1339
Full Name	cytochrome c oxidase subunit 6A2
Synonyms	COX6AH,COXVIAH
General protein information	Preferred Names cytochrome c oxidase subunit 6A2 Names cytochrome c oxidase subunit 6A2, mitochondrial COX VIa-M cytochrome c oxidase polypeptide VIa-heart cytochrome c oxidase subunit VIA-muscle cytochrome c oxidase subunit VIa polypeptide 2
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 16 Map Location: 16p11.2
Summary	Cytochrome c oxidase (COX), the terminal enzyme of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. It is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may be involved in the regulation and assembly of the complex. This nuclear gene encodes polypeptide 2 (heart/muscle isoform) of subunit VIa, and polypeptide 2 is present only in striated muscles. Polypeptide 1 (liver isoform) of subunit VIa is encoded by a different gene, and is found in all non-muscle tissues. These two polypeptides share 66% amino acid sequence identity. [provided by RefSeq, Jul 2008].
Disorder MIM:	602009

mRNA and Protein(s)

mRNA	Protein	Name
NM_005205.4	NP_005196.1	cytochrome c oxidase subunit 6A2, mitochondrial precursor
NM_005205.3	NP_005196.1	cytochrome c oxidase subunit 6A2, mitochondrial precursor

Pathways from BioSystems

Homologies

Bos taurus (cattle)	COX6A2	NP_776947.1
Homo sapiens (human)	COX6A2	NP_005196.1
Mus musculus (house mouse)	Cox6a2	NP_034073.2
Pan troglodytes (chimpanzee)	COX6A2	XP_001158801.1
Rattus norvegicus (Norway rat)	Cox6a2	NP_036944.2
	COX6A2	XP_001112927.1
Canis lupus familiaris (dog)	COX6A2	XP_536907.1

Gene Ontology
Bibliography

Related articles in PubMed

Structure of the human gene (COX6A2) for the heart/muscle isoform of cytochrome c oxidase subunit VIa and its chromosomal location in humans, mice, and cattle.
Bachman NJ, Riggs PK, Siddiqui N, Makris GJ, Womack JE, Lomax MI
Genomics42(1)146-51(1997 May)

Identification of 4370 expressed sequence tags from a 3'-end-specific cDNA library of human skeletal muscle by DNA sequencing and filter hybridization.
Lanfranchi G, Muraro T, Caldara F, Pacchioni B, Pallavicini A, Pandolfo D, Toppo S, Trevisan S, Scarso S, Valle G
Genome research6(1)35-42(1996 Jan)

Tissue distribution of cytochrome c oxidase isoforms in mammals. Characterization with monoclonal and polyclonal antibodies.
Taanman JW, Hall RE, Tang C, Marusich MF, Kennaway NG, Capaldi RA
Biochimica et biophysica acta1225(1)95-100(1993 Nov)

Differential expression of genes specifying two isoforms of subunit VIa of human cytochrome c oxidase.
Fabrizi GM, Sadlock J, Hirano M, Mita S, Koga Y, Rizzuto R, Zeviani M, Schon EA
Gene119(2)307-12(1992 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following COX6A2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the COX6A2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu09329	NM_005205.4 Latest version!	Homo sapiens cytochrome c oxidase subunit 6A2 (COX6A2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu09329	NM_005205.3	Homo sapiens cytochrome c oxidase subunit 6A2 (COX6A2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

COX6A2 ( NM_005205.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_005196.1 Homo sapiens cytochrome c oxidase subunit 6A2 (COX6A2), mRNA.

Price & Availability↑

CloneID	OHu09329
Clone ID Related Accession (Same CDS sequence)	NM_005205.4 , NM_005205.3
Accession Version	NM_005205.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 294bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-27
Organism	Homo sapiens(human)
Product	cytochrome c oxidase subunit 6A2, mitochondrial precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BP319904.1. On Nov 22, 2018 this sequence version replaced NM_005205.3. ##Evidence-Data-START## Transcript exon combination :: F24255.1, BP316949.2 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2155550, SAMEA2159607 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta MANE Ensembl match :: ENST00000287490.5/ ENSP00000287490.4 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCTTTGC CTCTGAGGCC CCTGACCCGG GGCTTGGCCA GCGCTGCCAA AGGAGGCCAC 
GGAGGAGCAG GAGCTCGTAC CTGGCGTCTG CTGACCTTCG TGCTGGCGCT GCCCAGCGTG 
GCCCTCTGCA CCTTCAACTC CTATCTCCAC TCGGGCCACC GCCCGCGCCC CGAGTTCCGT 
CCCTACCAAC ACCTCCGCAT CCGCACCAAG CCCTACCCCT GGGGGGACGG CAACCACACT 
CTGTTCCACA ATAGCCACGT GAACCCTCTG CCCACGGGCT ACGAACACCC CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005196.1
CDS	36..329
Translation	MALPLRPLTRGLASAAKGGHGGAGARTWRLLTFVLALPSVALCTFNSYLHSGHRPRPEFRPYQHLRIRTKPYPWGDGNHTLFHNSHVNPLPTGYEHP

Target ORF information:

RefSeq Version	NM_005205.4
Organism	Homo sapiens(human)
Definition	Homo sapiens cytochrome c oxidase subunit 6A2 (COX6A2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005205.4

ORF Insert Sequence:

ATGGCTTTGC CTCTGAGGCC CCTGACCCGG GGCTTGGCCA GCGCTGCCAA AGGAGGCCAC 
GGAGGAGCAG GAGCTCGTAC CTGGCGTCTG CTGACCTTCG TGCTGGCGCT GCCCAGCGTG 
GCCCTCTGCA CCTTCAACTC CTATCTCCAC TCGGGCCACC GCCCGCGCCC CGAGTTCCGT 
CCCTACCAAC ACCTCCGCAT CCGCACCAAG CCCTACCCCT GGGGGGACGG CAACCACACT 
CTGTTCCACA ATAGCCACGT GAACCCTCTG CCCACGGGCT ACGAACACCC CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

COX6A2 ( NM_005205.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_005196.1 Homo sapiens cytochrome c oxidase subunit 6A2 (COX6A2), mRNA.

Price & Availability↑

CloneID	OHu09329
Clone ID Related Accession (Same CDS sequence)	NM_005205.4 , NM_005205.3
Accession Version	NM_005205.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 294bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	cytochrome c oxidase subunit 6A2, mitochondrial precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BP319904.1. On Mar 4, 2011 this sequence version replaced NM_005205.2. ##Evidence-Data-START## Transcript exon combination :: BP319904.1, BM673956.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2155550, SAMEA2159607 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCTTTGC CTCTGAGGCC CCTGACCCGG GGCTTGGCCA GCGCTGCCAA AGGAGGCCAC 
GGAGGAGCAG GAGCTCGTAC CTGGCGTCTG CTGACCTTCG TGCTGGCGCT GCCCAGCGTG 
GCCCTCTGCA CCTTCAACTC CTATCTCCAC TCGGGCCACC GCCCGCGCCC CGAGTTCCGT 
CCCTACCAAC ACCTCCGCAT CCGCACCAAG CCCTACCCCT GGGGGGACGG CAACCACACT 
CTGTTCCACA ATAGCCACGT GAACCCTCTG CCCACGGGCT ACGAACACCC CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005196.1
CDS	104..397
Translation	MALPLRPLTRGLASAAKGGHGGAGARTWRLLTFVLALPSVALCTFNSYLHSGHRPRPEFRPYQHLRIRTKPYPWGDGNHTLFHNSHVNPLPTGYEHP

Target ORF information:

RefSeq Version	NM_005205.3
Organism	Homo sapiens(human)
Definition	Homo sapiens cytochrome c oxidase subunit 6A2 (COX6A2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005205.3

ORF Insert Sequence:

ATGGCTTTGC CTCTGAGGCC CCTGACCCGG GGCTTGGCCA GCGCTGCCAA AGGAGGCCAC 
GGAGGAGCAG GAGCTCGTAC CTGGCGTCTG CTGACCTTCG TGCTGGCGCT GCCCAGCGTG 
GCCCTCTGCA CCTTCAACTC CTATCTCCAC TCGGGCCACC GCCCGCGCCC CGAGTTCCGT 
CCCTACCAAC ACCTCCGCAT CCGCACCAAG CCCTACCCCT GGGGGGACGG CAACCACACT 
CTGTTCCACA ATAGCCACGT GAACCCTCTG CCCACGGGCT ACGAACACCC CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Structure of the human gene (COX6A2) for the heart/muscle isoform of cytochrome c oxidase subunit VIa and its chromosomal location in humans, mice, and cattle.
Genomics42(1)146-51(1997 May)
Bachman NJ,Riggs PK,Siddiqui N,Makris GJ,Womack JE,Lomax MI

Identification of 4370 expressed sequence tags from a 3'-end-specific cDNA library of human skeletal muscle by DNA sequencing and filter hybridization.
Genome research6(1)35-42(1996 Jan)
Lanfranchi G,Muraro T,Caldara F,Pacchioni B,Pallavicini A,Pandolfo D,Toppo S,Trevisan S,Scarso S,Valle G

Tissue distribution of cytochrome c oxidase isoforms in mammals. Characterization with monoclonal and polyclonal antibodies.
Biochimica et biophysica acta1225(1)95-100(1993 Nov)
Taanman JW,Hall RE,Tang C,Marusich MF,Kennaway NG,Capaldi RA

Differential expression of genes specifying two isoforms of subunit VIa of human cytochrome c oxidase.
Gene119(2)307-12(1992 Oct)
Fabrizi GM,Sadlock J,Hirano M,Mita S,Koga Y,Rizzuto R,Zeviani M,Schon EA