SGPP2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	SGPP2
Entrez Gene ID	130367
Full Name	sphingosine-1-phosphate phosphatase 2
Synonyms	SPP2,SPPase2
General protein information	Preferred Names sphingosine-1-phosphate phosphatase 2 Names sphingosine-1-phosphate phosphatase 2 sphingosine 1-phosphate phosphohydrolase 2 sphingosine-1-phosphatase 2 sphingosine-1-phosphate phosphotase 2
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 2 Map Location: 2q36.1
Summary	The protein encoded by this gene is a transmembrane protein that degrades the bioactive signaling molecule sphingosine 1-phosphate. The encoded protein is induced during inflammatory responses and has been shown to be downregulated by the microRNA-31 tumor suppressor. Alternative splice variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2016].
Disorder MIM:	612827

mRNA and Protein(s)

mRNA	Protein	Name
NM_001320833.2	NP_001307762.1	sphingosine-1-phosphate phosphatase 2 isoform b
NM_152386.4	NP_689599.2	sphingosine-1-phosphate phosphatase 2 isoform a
XM_017003355.1	XP_016858844.1	sphingosine-1-phosphate phosphatase 2 isoform X1
NM_001320833.1	NP_001307762.1	sphingosine-1-phosphate phosphatase 2 isoform b
NM_001320834.2	NP_001307763.1	sphingosine-1-phosphate phosphatase 2 isoform b
NM_001320834.1	NP_001307763.1	sphingosine-1-phosphate phosphatase 2 isoform b
NM_152386.3	NP_689599.2	sphingosine-1-phosphate phosphatase 2 isoform a

Pathways from BioSystems

Homologies

	SGPP2	XP_001107876.1
Bos taurus (cattle)	SGPP2	XP_003585820.1
Mus musculus (house mouse)	Sgpp2	NP_001004173.1
Pan troglodytes (chimpanzee)	SGPP2	XP_526109.2
Homo sapiens (human)	SGPP2	NP_689599.2
Rattus norvegicus (Norway rat)	Sgpp2	NP_001178740.1
Gallus gallus (chicken)	SGPP2	XP_422628.3
Danio rerio (zebrafish)	LOC100330698	XP_002664750.1
Xenopus tropicalis (tropical clawed frog)	sgpp2	XP_002936648.1

Gene Ontology
Bibliography

Related articles in PubMed

Sphingosine-1-phosphate Phosphatase 2 Regulates Pancreatic Islet ?-Cell Endoplasmic Reticulum Stress and Proliferation.
Taguchi Y, Allende ML, Mizukami H, Cook EK, Gavrilova O, Tuymetova G, Clarke BA, Chen W, Olivera A, Proia RL
The Journal of biological chemistry291(23)12029-38(2016 Jun)

Tumor suppressor microRNA-31 inhibits gastric carcinogenesis by targeting Smad4 and SGPP2.
Ruoming W, Zhen Y, Tengteng Z, Jisheng H
Cancer gene therapy22(12)564-72(2015 Dec)

Vitamin D-responsive SGPP2 variants associated with lung cell expression and lung function.
Reardon BJ, Hansen JG, Crystal RG, Houston DK, Kritchevsky SB, Harris T, Lohman K, Liu Y, O'Connor GT, Wilk JB, Mezey J, Gao C, Cassano PA
BMC medical genetics14122(2013 Nov)

Sphingosine pathway deregulation in endometriotic tissues.
Santulli P, Marcellin L, No?l JC, Borghese B, Fayt I, Vaiman D, Chapron C, M?hats C
Fertility and sterility97(4)904-11(2012 Apr)

Sphingosine 1-phosphate phosphatase 2 is induced during inflammatory responses.
Mechtcheriakova D, Wlachos A, Sobanov J, Kopp T, Reuschel R, Bornancin F, Cai R, Zemann B, Urtz N, Stingl G, Zlabinger G, Woisetschl?ger M, Baumruker T, Billich A
Cellular signalling19(4)748-60(2007 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

SGPP2, a sphingosine-1-phosphate phosphatase, is a novel vitamin D-responsive gene associated with lung function.
Title: Vitamin D-responsive SGPP2 variants associated with lung cell expression and lung function.

This study provides detailed insights into the regulation of SPP2 gene expression and suggests that SPP2 might be a novel player in pro-inflammatory signalling.
Title: Sphingosine 1-phosphate phosphatase 2 is induced during inflammatory responses.

characterization of SPP2, another member of the SPP family that may play a role in attenuating intracellular S1P signaling.
Title: Identification and characterization of a novel human sphingosine-1-phosphate phosphohydrolase, hSPP2.

The following SGPP2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SGPP2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu13186	NM_152386.4 Latest version!	Homo sapiens sphingosine-1-phosphate phosphatase 2 (SGPP2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
OHu35857	NM_001320834.2 Latest version!	Homo sapiens sphingosine-1-phosphate phosphatase 2 (SGPP2), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
OHu35857	NM_001320833.2 Latest version!	Homo sapiens sphingosine-1-phosphate phosphatase 2 (SGPP2), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
OHu35857	XM_017003355.1 Latest version!	Homo sapiens sphingosine-1-phosphate phosphatase 2 (SGPP2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
View Old Accession Versions >>
OHu35857	NM_001320833.1	Homo sapiens sphingosine-1-phosphate phosphatase 2 (SGPP2), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
OHu35857	NM_001320834.1	Homo sapiens sphingosine-1-phosphate phosphatase 2 (SGPP2), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
OHu13186	NM_152386.3	Homo sapiens sphingosine-1-phosphate phosphatase 2 (SGPP2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$237.30 $339.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

SGPP2 ( NM_152386.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_689599.2 Homo sapiens sphingosine-1-phosphate phosphatase 2 (SGPP2), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu13186
Clone ID Related Accession (Same CDS sequence)	NM_152386.4 , NM_152386.3
Accession Version	NM_152386.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1200bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-05-01
Organism	Homo sapiens(human)
Product	sphingosine-1-phosphate phosphatase 2 isoform a
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK314322.1, AF542512.1, AC097461.3 and BU676534.1. On Nov 23, 2018 this sequence version replaced NM_152386.3. Transcript Variant: This variant (1) encodes the longer isoform (a). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: SRR1803616.96913.1, SRR1660805.197603.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000321276.8/ ENSP00000315137.7 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCCGAGC TGCTGCGGAG CCTGCAGGAT TCCCAGCTCG TCGCCCGCTT CCAGCGCCGC 
TGCGGGCTCT TCCCCGCTCC GGATGAAGGC CCCCGGGAGA ACGGCGCGGA CCCCACGGAG 
CGCGCGGCGC GGGTCCCCGG GGTCGAGCAT CTCCCCGCAG CCAACGGCAA GGGCGGCGAG 
GCTCCGGCCA ACGGGCTGCG CAGAGCCGCG GCGCCGGAGG CTTATGTACA GAAGTACGTC 
GTGAAGAATT ATTTCTACTA TTACCTATTC CAATTTTCAG CTGCTTTGGG CCAAGAAGTG 
TTCTACATCA CGTTTCTTCC ATTCACTCAC TGGAATATTG ACCCTTATTT ATCCAGAAGA 
TTGATCATCA TATGGGTTTT GGTGATGTAT ATTGGCCAAG TGGCCAAGGA TGTCTTGAAG 
TGGCCCCGTC CCTCCTCCCC TCCAGTTGTA AAACTGGAAA AGAGACTGAT CGCTGAATAT 
GGAATGCCAT CCACCCACGC CATGGCGGCC ACTGCCATTG CCTTCACCCT CCTTATCTCT 
ACTATGGACA GATACCAGTA TCCATTTGTG TTGGGACTGG TGATGGCCGT GGTGTTTTCC 
ACCTTGGTGT GTCTCAGCAG GCTCTACACT GGGATGCATA CGGTCCTGGA TGTGCTGGGT 
GGCGTCCTGA TCACCGCACT CCTCATCGTC CTCACCTACC CTGCCTGGAC CTTCATCGAC 
TGCCTGGACT CGGCCAGCCC CCTCTTCCCC GTGTGTGTCA TAGTTGTGCC ATTCTTCCTG 
TGTTACAATT ACCCTGTTTC TGATTACTAC AGCCCAACCC GGGCGGACAC CACCACCATT 
CTGGCTGCCG GGGCTGGAGT GACCATAGGA TTCTGGATCA ACCATTTCTT CCAGCTTGTA 
TCCAAGCCCG CTGAATCTCT CCCTGTTATT CAGAACATCC CACCACTCAC CACCTACATG 
TTAGTTTTGG GTCTGACCAA ATTTGCAGTG GGAATTGTGT TGATCCTCTT GGTTCGTCAG 
CTTGTACAAA ATCTCTCACT GCAAGTATTA TACTCATGGT TCAAGGTGGT CACCAGGAAC 
AAGGAGGCCA GGCGGAGACT GGAGATTGAA GTGCCTTACA AGTTTGTTAC CTACACATCT 
GTTGGCATCT GCGCTACAAC CTTTGTGCCG ATGCTTCACA GGTTTCTGGG ATTACCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_689599.2
CDS	61..1260
Translation	MAELLRSLQDSQLVARFQRRCGLFPAPDEGPRENGADPTERAARVPGVEHLPAANGKGGEAPANGLRRAAAPEAYVQKYVVKNYFYYYLFQFSAALGQEVFYITFLPFTHWNIDPYLSRRLIIIWVLVMYIGQVAKDVLKWPRPSSPPVVKLEKRLIAEYGMPSTHAMAATAIAFTLLISTMDRYQYPFVLGLVMAVVFSTLVCLSRLYTGMHTVLDVLGGVLITALLIVLTYPAWTFIDCLDSASPLFPVCVIVVPFFLCYNYPVSDYYSPTRADTTTILAAGAGVTIGFWINHFFQLVSKPAESLPVIQNIPPLTTYMLVLGLTKFAVGIVLILLVRQLVQNLSLQVLYSWFKVVTRNKEARRRLEIEVPYKFVTYTSVGICATTFVPMLHRFLGLP

Target ORF information:

RefSeq Version	NM_152386.4
Organism	Homo sapiens(human)
Definition	Homo sapiens sphingosine-1-phosphate phosphatase 2 (SGPP2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_152386.4

ORF Insert Sequence:

ATGGCCGAGC TGCTGCGGAG CCTGCAGGAT TCCCAGCTCG TCGCCCGCTT CCAGCGCCGC 
TGCGGGCTCT TCCCCGCTCC GGATGAAGGC CCCCGGGAGA ACGGCGCGGA CCCCACGGAG 
CGCGCGGCGC GGGTCCCCGG GGTCGAGCAT CTCCCCGCAG CCAACGGCAA GGGCGGCGAG 
GCTCCGGCCA ACGGGCTGCG CAGAGCCGCG GCGCCGGAGG CTTATGTACA GAAGTACGTC 
GTGAAGAATT ATTTCTACTA TTACCTATTC CAATTTTCAG CTGCTTTGGG CCAAGAAGTG 
TTCTACATCA CGTTTCTTCC ATTCACTCAC TGGAATATTG ACCCTTATTT ATCCAGAAGA 
TTGATCATCA TATGGGTTTT GGTGATGTAT ATTGGCCAAG TGGCCAAGGA TGTCTTGAAG 
TGGCCCCGTC CCTCCTCCCC TCCAGTTGTA AAACTGGAAA AGAGACTGAT CGCTGAATAT 
GGAATGCCAT CCACCCACGC CATGGCGGCC ACTGCCATTG CCTTCACCCT CCTTATCTCT 
ACTATGGACA GATACCAGTA TCCATTTGTG TTGGGACTGG TGATGGCCGT GGTGTTTTCC 
ACCTTGGTGT GTCTCAGCAG GCTCTACACT GGGATGCATA CGGTCCTGGA TGTGCTGGGT 
GGCGTCCTGA TCACCGCACT CCTCATCGTC CTCACCTACC CTGCCTGGAC CTTCATCGAC 
TGCCTGGACT CGGCCAGCCC CCTCTTCCCC GTGTGTGTCA TAGTTGTGCC ATTCTTCCTG 
TGTTACAATT ACCCTGTTTC TGATTACTAC AGCCCAACCC GGGCGGACAC CACCACCATT 
CTGGCTGCCG GGGCTGGAGT GACCATAGGA TTCTGGATCA ACCATTTCTT CCAGCTTGTA 
TCCAAGCCCG CTGAATCTCT CCCTGTTATT CAGAACATCC CACCACTCAC CACCTACATG 
TTAGTTTTGG GTCTGACCAA ATTTGCAGTG GGAATTGTGT TGATCCTCTT GGTTCGTCAG 
CTTGTACAAA ATCTCTCACT GCAAGTATTA TACTCATGGT TCAAGGTGGT CACCAGGAAC 
AAGGAGGCCA GGCGGAGACT GGAGATTGAA GTGCCTTACA AGTTTGTTAC CTACACATCT 
GTTGGCATCT GCGCTACAAC CTTTGTGCCG ATGCTTCACA GGTTTCTGGG ATTACCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SGPP2 ( NM_001320833.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001307762.1 Homo sapiens sphingosine-1-phosphate phosphatase 2 (SGPP2), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu35857
Clone ID Related Accession (Same CDS sequence)	NM_001320833.2 , XM_017003355.1 , NM_001320833.1 , NM_001320834.2 , NM_001320834.1
Accession Version	NM_001320833.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 816bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-05-30
Organism	Homo sapiens(human)
Product	sphingosine-1-phosphate phosphatase 2 isoform b
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK314322.1, BC114513.1, AC097461.3 and BU676534.1. On May 31, 2019 this sequence version replaced NM_001320833.1. Transcript Variant: This variant (2) contains an alternate exon in the 5' end compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2 and 3 both encode the same isoform (b). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: BC114513.1 [ECO:0000332] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTATATTG GCCAAGTGGC CAAGGATGTC TTGAAGTGGC CCCGTCCCTC CTCCCCTCCA 
GTTGTAAAAC TGGAAAAGAG ACTGATCGCT GAATATGGAA TGCCATCCAC CCACGCCATG 
GCGGCCACTG CCATTGCCTT CACCCTCCTT ATCTCTACTA TGGACAGATA CCAGTATCCA 
TTTGTGTTGG GACTGGTGAT GGCCGTGGTG TTTTCCACCT TGGTGTGTCT CAGCAGGCTC 
TACACTGGGA TGCATACGGT CCTGGATGTG CTGGGTGGCG TCCTGATCAC CGCACTCCTC 
ATCGTCCTCA CCTACCCTGC CTGGACCTTC ATCGACTGCC TGGACTCGGC CAGCCCCCTC 
TTCCCCGTGT GTGTCATAGT TGTGCCATTC TTCCTGTGTT ACAATTACCC TGTTTCTGAT 
TACTACAGCC CAACCCGGGC GGACACCACC ACCATTCTGG CTGCCGGGGC TGGAGTGACC 
ATAGGATTCT GGATCAACCA TTTCTTCCAG CTTGTATCCA AGCCCGCTGA ATCTCTCCCT 
GTTATTCAGA ACATCCCACC ACTCACCACC TACATGTTAG TTTTGGGTCT GACCAAATTT 
GCAGTGGGAA TTGTGTTGAT CCTCTTGGTT CGTCAGCTTG TACAAAATCT CTCACTGCAA 
GTATTATACT CATGGTTCAA GGTGGTCACC AGGAACAAGG AGGCCAGGCG GAGACTGGAG 
ATTGAAGTGC CTTACAAGTT TGTTACCTAC ACATCTGTTG GCATCTGCGC TACAACCTTT 
GTGCCGATGC TTCACAGGTT TCTGGGATTA CCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001307762.1
CDS	588..1403
Translation	MYIGQVAKDVLKWPRPSSPPVVKLEKRLIAEYGMPSTHAMAATAIAFTLLISTMDRYQYPFVLGLVMAVVFSTLVCLSRLYTGMHTVLDVLGGVLITALLIVLTYPAWTFIDCLDSASPLFPVCVIVVPFFLCYNYPVSDYYSPTRADTTTILAAGAGVTIGFWINHFFQLVSKPAESLPVIQNIPPLTTYMLVLGLTKFAVGIVLILLVRQLVQNLSLQVLYSWFKVVTRNKEARRRLEIEVPYKFVTYTSVGICATTFVPMLHRFLGLP

Target ORF information:

RefSeq Version	NM_001320833.2
Organism	Homo sapiens(human)
Definition	Homo sapiens sphingosine-1-phosphate phosphatase 2 (SGPP2), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001320833.2

ORF Insert Sequence:

ATGTATATTG GCCAAGTGGC CAAGGATGTC TTGAAGTGGC CCCGTCCCTC CTCCCCTCCA 
GTTGTAAAAC TGGAAAAGAG ACTGATCGCT GAATATGGAA TGCCATCCAC CCACGCCATG 
GCGGCCACTG CCATTGCCTT CACCCTCCTT ATCTCTACTA TGGACAGATA CCAGTATCCA 
TTTGTGTTGG GACTGGTGAT GGCCGTGGTG TTTTCCACCT TGGTGTGTCT CAGCAGGCTC 
TACACTGGGA TGCATACGGT CCTGGATGTG CTGGGTGGCG TCCTGATCAC CGCACTCCTC 
ATCGTCCTCA CCTACCCTGC CTGGACCTTC ATCGACTGCC TGGACTCGGC CAGCCCCCTC 
TTCCCCGTGT GTGTCATAGT TGTGCCATTC TTCCTGTGTT ACAATTACCC TGTTTCTGAT 
TACTACAGCC CAACCCGGGC GGACACCACC ACCATTCTGG CTGCCGGGGC TGGAGTGACC 
ATAGGATTCT GGATCAACCA TTTCTTCCAG CTTGTATCCA AGCCCGCTGA ATCTCTCCCT 
GTTATTCAGA ACATCCCACC ACTCACCACC TACATGTTAG TTTTGGGTCT GACCAAATTT 
GCAGTGGGAA TTGTGTTGAT CCTCTTGGTT CGTCAGCTTG TACAAAATCT CTCACTGCAA 
GTATTATACT CATGGTTCAA GGTGGTCACC AGGAACAAGG AGGCCAGGCG GAGACTGGAG 
ATTGAAGTGC CTTACAAGTT TGTTACCTAC ACATCTGTTG GCATCTGCGC TACAACCTTT 
GTGCCGATGC TTCACAGGTT TCTGGGATTA CCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SGPP2 ( NM_001320833.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001307762.1 Homo sapiens sphingosine-1-phosphate phosphatase 2 (SGPP2), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu35857
Clone ID Related Accession (Same CDS sequence)	NM_001320833.2 , XM_017003355.1 , NM_001320833.1 , NM_001320834.2 , NM_001320834.1
Accession Version	NM_001320833.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 816bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-06-30
Organism	Homo sapiens(human)
Product	sphingosine-1-phosphate phosphatase 2 isoform b
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK314322.1, BC114513.1, AC097461.3 and BU676534.1. Transcript Variant: This variant (2) contains an alternate exon in the 5' end compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2 and 3 both encode the same isoform (b). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: BC114513.1 [ECO:0000332] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTATATTG GCCAAGTGGC CAAGGATGTC TTGAAGTGGC CCCGTCCCTC CTCCCCTCCA 
GTTGTAAAAC TGGAAAAGAG ACTGATCGCT GAATATGGAA TGCCATCCAC CCACGCCATG 
GCGGCCACTG CCATTGCCTT CACCCTCCTT ATCTCTACTA TGGACAGATA CCAGTATCCA 
TTTGTGTTGG GACTGGTGAT GGCCGTGGTG TTTTCCACCT TGGTGTGTCT CAGCAGGCTC 
TACACTGGGA TGCATACGGT CCTGGATGTG CTGGGTGGCG TCCTGATCAC CGCACTCCTC 
ATCGTCCTCA CCTACCCTGC CTGGACCTTC ATCGACTGCC TGGACTCGGC CAGCCCCCTC 
TTCCCCGTGT GTGTCATAGT TGTGCCATTC TTCCTGTGTT ACAATTACCC TGTTTCTGAT 
TACTACAGCC CAACCCGGGC GGACACCACC ACCATTCTGG CTGCCGGGGC TGGAGTGACC 
ATAGGATTCT GGATCAACCA TTTCTTCCAG CTTGTATCCA AGCCCGCTGA ATCTCTCCCT 
GTTATTCAGA ACATCCCACC ACTCACCACC TACATGTTAG TTTTGGGTCT GACCAAATTT 
GCAGTGGGAA TTGTGTTGAT CCTCTTGGTT CGTCAGCTTG TACAAAATCT CTCACTGCAA 
GTATTATACT CATGGTTCAA GGTGGTCACC AGGAACAAGG AGGCCAGGCG GAGACTGGAG 
ATTGAAGTGC CTTACAAGTT TGTTACCTAC ACATCTGTTG GCATCTGCGC TACAACCTTT 
GTGCCGATGC TTCACAGGTT TCTGGGATTA CCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001307762.1
CDS	624..1439
Translation	MYIGQVAKDVLKWPRPSSPPVVKLEKRLIAEYGMPSTHAMAATAIAFTLLISTMDRYQYPFVLGLVMAVVFSTLVCLSRLYTGMHTVLDVLGGVLITALLIVLTYPAWTFIDCLDSASPLFPVCVIVVPFFLCYNYPVSDYYSPTRADTTTILAAGAGVTIGFWINHFFQLVSKPAESLPVIQNIPPLTTYMLVLGLTKFAVGIVLILLVRQLVQNLSLQVLYSWFKVVTRNKEARRRLEIEVPYKFVTYTSVGICATTFVPMLHRFLGLP

Target ORF information:

RefSeq Version	NM_001320833.1
Organism	Homo sapiens(human)
Definition	Homo sapiens sphingosine-1-phosphate phosphatase 2 (SGPP2), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001320833.1

ORF Insert Sequence:

ATGTATATTG GCCAAGTGGC CAAGGATGTC TTGAAGTGGC CCCGTCCCTC CTCCCCTCCA 
GTTGTAAAAC TGGAAAAGAG ACTGATCGCT GAATATGGAA TGCCATCCAC CCACGCCATG 
GCGGCCACTG CCATTGCCTT CACCCTCCTT ATCTCTACTA TGGACAGATA CCAGTATCCA 
TTTGTGTTGG GACTGGTGAT GGCCGTGGTG TTTTCCACCT TGGTGTGTCT CAGCAGGCTC 
TACACTGGGA TGCATACGGT CCTGGATGTG CTGGGTGGCG TCCTGATCAC CGCACTCCTC 
ATCGTCCTCA CCTACCCTGC CTGGACCTTC ATCGACTGCC TGGACTCGGC CAGCCCCCTC 
TTCCCCGTGT GTGTCATAGT TGTGCCATTC TTCCTGTGTT ACAATTACCC TGTTTCTGAT 
TACTACAGCC CAACCCGGGC GGACACCACC ACCATTCTGG CTGCCGGGGC TGGAGTGACC 
ATAGGATTCT GGATCAACCA TTTCTTCCAG CTTGTATCCA AGCCCGCTGA ATCTCTCCCT 
GTTATTCAGA ACATCCCACC ACTCACCACC TACATGTTAG TTTTGGGTCT GACCAAATTT 
GCAGTGGGAA TTGTGTTGAT CCTCTTGGTT CGTCAGCTTG TACAAAATCT CTCACTGCAA 
GTATTATACT CATGGTTCAA GGTGGTCACC AGGAACAAGG AGGCCAGGCG GAGACTGGAG 
ATTGAAGTGC CTTACAAGTT TGTTACCTAC ACATCTGTTG GCATCTGCGC TACAACCTTT 
GTGCCGATGC TTCACAGGTT TCTGGGATTA CCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SGPP2 ( NM_001320834.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001307763.1 Homo sapiens sphingosine-1-phosphate phosphatase 2 (SGPP2), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu35857
Clone ID Related Accession (Same CDS sequence)	NM_001320833.2 , XM_017003355.1 , NM_001320833.1 , NM_001320834.2 , NM_001320834.1
Accession Version	NM_001320834.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 816bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-05-30
Organism	Homo sapiens(human)
Product	sphingosine-1-phosphate phosphatase 2 isoform b
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC112718.3, AK096323.1, AC097461.3 and BU676534.1. On May 31, 2019 this sequence version replaced NM_001320834.1. Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2 and 3 both encode the same isoform (b). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: SRR1803613.214643.1, AK096323.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTATATTG GCCAAGTGGC CAAGGATGTC TTGAAGTGGC CCCGTCCCTC CTCCCCTCCA 
GTTGTAAAAC TGGAAAAGAG ACTGATCGCT GAATATGGAA TGCCATCCAC CCACGCCATG 
GCGGCCACTG CCATTGCCTT CACCCTCCTT ATCTCTACTA TGGACAGATA CCAGTATCCA 
TTTGTGTTGG GACTGGTGAT GGCCGTGGTG TTTTCCACCT TGGTGTGTCT CAGCAGGCTC 
TACACTGGGA TGCATACGGT CCTGGATGTG CTGGGTGGCG TCCTGATCAC CGCACTCCTC 
ATCGTCCTCA CCTACCCTGC CTGGACCTTC ATCGACTGCC TGGACTCGGC CAGCCCCCTC 
TTCCCCGTGT GTGTCATAGT TGTGCCATTC TTCCTGTGTT ACAATTACCC TGTTTCTGAT 
TACTACAGCC CAACCCGGGC GGACACCACC ACCATTCTGG CTGCCGGGGC TGGAGTGACC 
ATAGGATTCT GGATCAACCA TTTCTTCCAG CTTGTATCCA AGCCCGCTGA ATCTCTCCCT 
GTTATTCAGA ACATCCCACC ACTCACCACC TACATGTTAG TTTTGGGTCT GACCAAATTT 
GCAGTGGGAA TTGTGTTGAT CCTCTTGGTT CGTCAGCTTG TACAAAATCT CTCACTGCAA 
GTATTATACT CATGGTTCAA GGTGGTCACC AGGAACAAGG AGGCCAGGCG GAGACTGGAG 
ATTGAAGTGC CTTACAAGTT TGTTACCTAC ACATCTGTTG GCATCTGCGC TACAACCTTT 
GTGCCGATGC TTCACAGGTT TCTGGGATTA CCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001307763.1
CDS	257..1072
Translation	MYIGQVAKDVLKWPRPSSPPVVKLEKRLIAEYGMPSTHAMAATAIAFTLLISTMDRYQYPFVLGLVMAVVFSTLVCLSRLYTGMHTVLDVLGGVLITALLIVLTYPAWTFIDCLDSASPLFPVCVIVVPFFLCYNYPVSDYYSPTRADTTTILAAGAGVTIGFWINHFFQLVSKPAESLPVIQNIPPLTTYMLVLGLTKFAVGIVLILLVRQLVQNLSLQVLYSWFKVVTRNKEARRRLEIEVPYKFVTYTSVGICATTFVPMLHRFLGLP

Target ORF information:

RefSeq Version	NM_001320834.2
Organism	Homo sapiens(human)
Definition	Homo sapiens sphingosine-1-phosphate phosphatase 2 (SGPP2), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001320834.2

ORF Insert Sequence:

ATGTATATTG GCCAAGTGGC CAAGGATGTC TTGAAGTGGC CCCGTCCCTC CTCCCCTCCA 
GTTGTAAAAC TGGAAAAGAG ACTGATCGCT GAATATGGAA TGCCATCCAC CCACGCCATG 
GCGGCCACTG CCATTGCCTT CACCCTCCTT ATCTCTACTA TGGACAGATA CCAGTATCCA 
TTTGTGTTGG GACTGGTGAT GGCCGTGGTG TTTTCCACCT TGGTGTGTCT CAGCAGGCTC 
TACACTGGGA TGCATACGGT CCTGGATGTG CTGGGTGGCG TCCTGATCAC CGCACTCCTC 
ATCGTCCTCA CCTACCCTGC CTGGACCTTC ATCGACTGCC TGGACTCGGC CAGCCCCCTC 
TTCCCCGTGT GTGTCATAGT TGTGCCATTC TTCCTGTGTT ACAATTACCC TGTTTCTGAT 
TACTACAGCC CAACCCGGGC GGACACCACC ACCATTCTGG CTGCCGGGGC TGGAGTGACC 
ATAGGATTCT GGATCAACCA TTTCTTCCAG CTTGTATCCA AGCCCGCTGA ATCTCTCCCT 
GTTATTCAGA ACATCCCACC ACTCACCACC TACATGTTAG TTTTGGGTCT GACCAAATTT 
GCAGTGGGAA TTGTGTTGAT CCTCTTGGTT CGTCAGCTTG TACAAAATCT CTCACTGCAA 
GTATTATACT CATGGTTCAA GGTGGTCACC AGGAACAAGG AGGCCAGGCG GAGACTGGAG 
ATTGAAGTGC CTTACAAGTT TGTTACCTAC ACATCTGTTG GCATCTGCGC TACAACCTTT 
GTGCCGATGC TTCACAGGTT TCTGGGATTA CCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SGPP2 ( NM_001320834.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001307763.1 Homo sapiens sphingosine-1-phosphate phosphatase 2 (SGPP2), transcript variant 3, mRNA.

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CloneID	OHu35857
Clone ID Related Accession (Same CDS sequence)	NM_001320833.2 , XM_017003355.1 , NM_001320833.1 , NM_001320834.2 , NM_001320834.1
Accession Version	NM_001320834.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 816bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-06-30
Organism	Homo sapiens(human)
Product	sphingosine-1-phosphate phosphatase 2 isoform b
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK096323.1, AC097461.3 and BU676534.1. On Mar 9, 2016 this sequence version replaced XM_005246297.2. Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2 and 3 both encode the same isoform (b). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: SRR1803613.214643.1, AK096323.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTATATTG GCCAAGTGGC CAAGGATGTC TTGAAGTGGC CCCGTCCCTC CTCCCCTCCA 
GTTGTAAAAC TGGAAAAGAG ACTGATCGCT GAATATGGAA TGCCATCCAC CCACGCCATG 
GCGGCCACTG CCATTGCCTT CACCCTCCTT ATCTCTACTA TGGACAGATA CCAGTATCCA 
TTTGTGTTGG GACTGGTGAT GGCCGTGGTG TTTTCCACCT TGGTGTGTCT CAGCAGGCTC 
TACACTGGGA TGCATACGGT CCTGGATGTG CTGGGTGGCG TCCTGATCAC CGCACTCCTC 
ATCGTCCTCA CCTACCCTGC CTGGACCTTC ATCGACTGCC TGGACTCGGC CAGCCCCCTC 
TTCCCCGTGT GTGTCATAGT TGTGCCATTC TTCCTGTGTT ACAATTACCC TGTTTCTGAT 
TACTACAGCC CAACCCGGGC GGACACCACC ACCATTCTGG CTGCCGGGGC TGGAGTGACC 
ATAGGATTCT GGATCAACCA TTTCTTCCAG CTTGTATCCA AGCCCGCTGA ATCTCTCCCT 
GTTATTCAGA ACATCCCACC ACTCACCACC TACATGTTAG TTTTGGGTCT GACCAAATTT 
GCAGTGGGAA TTGTGTTGAT CCTCTTGGTT CGTCAGCTTG TACAAAATCT CTCACTGCAA 
GTATTATACT CATGGTTCAA GGTGGTCACC AGGAACAAGG AGGCCAGGCG GAGACTGGAG 
ATTGAAGTGC CTTACAAGTT TGTTACCTAC ACATCTGTTG GCATCTGCGC TACAACCTTT 
GTGCCGATGC TTCACAGGTT TCTGGGATTA CCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001307763.1
CDS	193..1008
Translation	MYIGQVAKDVLKWPRPSSPPVVKLEKRLIAEYGMPSTHAMAATAIAFTLLISTMDRYQYPFVLGLVMAVVFSTLVCLSRLYTGMHTVLDVLGGVLITALLIVLTYPAWTFIDCLDSASPLFPVCVIVVPFFLCYNYPVSDYYSPTRADTTTILAAGAGVTIGFWINHFFQLVSKPAESLPVIQNIPPLTTYMLVLGLTKFAVGIVLILLVRQLVQNLSLQVLYSWFKVVTRNKEARRRLEIEVPYKFVTYTSVGICATTFVPMLHRFLGLP

Target ORF information:

RefSeq Version	NM_001320834.1
Organism	Homo sapiens(human)
Definition	Homo sapiens sphingosine-1-phosphate phosphatase 2 (SGPP2), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001320834.1

ORF Insert Sequence:

ATGTATATTG GCCAAGTGGC CAAGGATGTC TTGAAGTGGC CCCGTCCCTC CTCCCCTCCA 
GTTGTAAAAC TGGAAAAGAG ACTGATCGCT GAATATGGAA TGCCATCCAC CCACGCCATG 
GCGGCCACTG CCATTGCCTT CACCCTCCTT ATCTCTACTA TGGACAGATA CCAGTATCCA 
TTTGTGTTGG GACTGGTGAT GGCCGTGGTG TTTTCCACCT TGGTGTGTCT CAGCAGGCTC 
TACACTGGGA TGCATACGGT CCTGGATGTG CTGGGTGGCG TCCTGATCAC CGCACTCCTC 
ATCGTCCTCA CCTACCCTGC CTGGACCTTC ATCGACTGCC TGGACTCGGC CAGCCCCCTC 
TTCCCCGTGT GTGTCATAGT TGTGCCATTC TTCCTGTGTT ACAATTACCC TGTTTCTGAT 
TACTACAGCC CAACCCGGGC GGACACCACC ACCATTCTGG CTGCCGGGGC TGGAGTGACC 
ATAGGATTCT GGATCAACCA TTTCTTCCAG CTTGTATCCA AGCCCGCTGA ATCTCTCCCT 
GTTATTCAGA ACATCCCACC ACTCACCACC TACATGTTAG TTTTGGGTCT GACCAAATTT 
GCAGTGGGAA TTGTGTTGAT CCTCTTGGTT CGTCAGCTTG TACAAAATCT CTCACTGCAA 
GTATTATACT CATGGTTCAA GGTGGTCACC AGGAACAAGG AGGCCAGGCG GAGACTGGAG 
ATTGAAGTGC CTTACAAGTT TGTTACCTAC ACATCTGTTG GCATCTGCGC TACAACCTTT 
GTGCCGATGC TTCACAGGTT TCTGGGATTA CCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SGPP2 ( XM_017003355.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016858844.1 Homo sapiens sphingosine-1-phosphate phosphatase 2 (SGPP2), transcript variant X1, mRNA.

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CloneID	OHu35857
Clone ID Related Accession (Same CDS sequence)	NM_001320833.2 , XM_017003355.1 , NM_001320833.1 , NM_001320834.2 , NM_001320834.1
Accession Version	XM_017003355.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 816bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	sphingosine-1-phosphate phosphatase 2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000002.12) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTATATTG GCCAAGTGGC CAAGGATGTC TTGAAGTGGC CCCGTCCCTC CTCCCCTCCA 
GTTGTAAAAC TGGAAAAGAG ACTGATCGCT GAATATGGAA TGCCATCCAC CCACGCCATG 
GCGGCCACTG CCATTGCCTT CACCCTCCTT ATCTCTACTA TGGACAGATA CCAGTATCCA 
TTTGTGTTGG GACTGGTGAT GGCCGTGGTG TTTTCCACCT TGGTGTGTCT CAGCAGGCTC 
TACACTGGGA TGCATACGGT CCTGGATGTG CTGGGTGGCG TCCTGATCAC CGCACTCCTC 
ATCGTCCTCA CCTACCCTGC CTGGACCTTC ATCGACTGCC TGGACTCGGC CAGCCCCCTC 
TTCCCCGTGT GTGTCATAGT TGTGCCATTC TTCCTGTGTT ACAATTACCC TGTTTCTGAT 
TACTACAGCC CAACCCGGGC GGACACCACC ACCATTCTGG CTGCCGGGGC TGGAGTGACC 
ATAGGATTCT GGATCAACCA TTTCTTCCAG CTTGTATCCA AGCCCGCTGA ATCTCTCCCT 
GTTATTCAGA ACATCCCACC ACTCACCACC TACATGTTAG TTTTGGGTCT GACCAAATTT 
GCAGTGGGAA TTGTGTTGAT CCTCTTGGTT CGTCAGCTTG TACAAAATCT CTCACTGCAA 
GTATTATACT CATGGTTCAA GGTGGTCACC AGGAACAAGG AGGCCAGGCG GAGACTGGAG 
ATTGAAGTGC CTTACAAGTT TGTTACCTAC ACATCTGTTG GCATCTGCGC TACAACCTTT 
GTGCCGATGC TTCACAGGTT TCTGGGATTA CCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016858844.1
CDS	383..1198
Translation	MYIGQVAKDVLKWPRPSSPPVVKLEKRLIAEYGMPSTHAMAATAIAFTLLISTMDRYQYPFVLGLVMAVVFSTLVCLSRLYTGMHTVLDVLGGVLITALLIVLTYPAWTFIDCLDSASPLFPVCVIVVPFFLCYNYPVSDYYSPTRADTTTILAAGAGVTIGFWINHFFQLVSKPAESLPVIQNIPPLTTYMLVLGLTKFAVGIVLILLVRQLVQNLSLQVLYSWFKVVTRNKEARRRLEIEVPYKFVTYTSVGICATTFVPMLHRFLGLP

Target ORF information:

RefSeq Version	XM_017003355.1
Organism	Homo sapiens(human)
Definition	Homo sapiens sphingosine-1-phosphate phosphatase 2 (SGPP2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017003355.1

ORF Insert Sequence:

ATGTATATTG GCCAAGTGGC CAAGGATGTC TTGAAGTGGC CCCGTCCCTC CTCCCCTCCA 
GTTGTAAAAC TGGAAAAGAG ACTGATCGCT GAATATGGAA TGCCATCCAC CCACGCCATG 
GCGGCCACTG CCATTGCCTT CACCCTCCTT ATCTCTACTA TGGACAGATA CCAGTATCCA 
TTTGTGTTGG GACTGGTGAT GGCCGTGGTG TTTTCCACCT TGGTGTGTCT CAGCAGGCTC 
TACACTGGGA TGCATACGGT CCTGGATGTG CTGGGTGGCG TCCTGATCAC CGCACTCCTC 
ATCGTCCTCA CCTACCCTGC CTGGACCTTC ATCGACTGCC TGGACTCGGC CAGCCCCCTC 
TTCCCCGTGT GTGTCATAGT TGTGCCATTC TTCCTGTGTT ACAATTACCC TGTTTCTGAT 
TACTACAGCC CAACCCGGGC GGACACCACC ACCATTCTGG CTGCCGGGGC TGGAGTGACC 
ATAGGATTCT GGATCAACCA TTTCTTCCAG CTTGTATCCA AGCCCGCTGA ATCTCTCCCT 
GTTATTCAGA ACATCCCACC ACTCACCACC TACATGTTAG TTTTGGGTCT GACCAAATTT 
GCAGTGGGAA TTGTGTTGAT CCTCTTGGTT CGTCAGCTTG TACAAAATCT CTCACTGCAA 
GTATTATACT CATGGTTCAA GGTGGTCACC AGGAACAAGG AGGCCAGGCG GAGACTGGAG 
ATTGAAGTGC CTTACAAGTT TGTTACCTAC ACATCTGTTG GCATCTGCGC TACAACCTTT 
GTGCCGATGC TTCACAGGTT TCTGGGATTA CCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SGPP2 ( NM_152386.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_689599.2 Homo sapiens sphingosine-1-phosphate phosphatase 2 (SGPP2), transcript variant 1, mRNA.

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CloneID	OHu13186
Clone ID Related Accession (Same CDS sequence)	NM_152386.4 , NM_152386.3
Accession Version	NM_152386.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1200bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-02
Organism	Homo sapiens(human)
Product	sphingosine-1-phosphate phosphatase 2 isoform a
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK314322.1, AF542512.1, AC097461.3 and BU676534.1. On Mar 9, 2016 this sequence version replaced NM_152386.2. Transcript Variant: This variant (1) encodes the longer isoform (a). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: AK314322.1, SRR1660805.197603.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCCGAGC TGCTGCGGAG CCTGCAGGAT TCCCAGCTCG TCGCCCGCTT CCAGCGCCGC 
TGCGGGCTCT TCCCCGCTCC GGATGAAGGC CCCCGGGAGA ACGGCGCGGA CCCCACGGAG 
CGCGCGGCGC GGGTCCCCGG GGTCGAGCAT CTCCCCGCAG CCAACGGCAA GGGCGGCGAG 
GCTCCGGCCA ACGGGCTGCG CAGAGCCGCG GCGCCGGAGG CTTATGTACA GAAGTACGTC 
GTGAAGAATT ATTTCTACTA TTACCTATTC CAATTTTCAG CTGCTTTGGG CCAAGAAGTG 
TTCTACATCA CGTTTCTTCC ATTCACTCAC TGGAATATTG ACCCTTATTT ATCCAGAAGA 
TTGATCATCA TATGGGTTTT GGTGATGTAT ATTGGCCAAG TGGCCAAGGA TGTCTTGAAG 
TGGCCCCGTC CCTCCTCCCC TCCAGTTGTA AAACTGGAAA AGAGACTGAT CGCTGAATAT 
GGAATGCCAT CCACCCACGC CATGGCGGCC ACTGCCATTG CCTTCACCCT CCTTATCTCT 
ACTATGGACA GATACCAGTA TCCATTTGTG TTGGGACTGG TGATGGCCGT GGTGTTTTCC 
ACCTTGGTGT GTCTCAGCAG GCTCTACACT GGGATGCATA CGGTCCTGGA TGTGCTGGGT 
GGCGTCCTGA TCACCGCACT CCTCATCGTC CTCACCTACC CTGCCTGGAC CTTCATCGAC 
TGCCTGGACT CGGCCAGCCC CCTCTTCCCC GTGTGTGTCA TAGTTGTGCC ATTCTTCCTG 
TGTTACAATT ACCCTGTTTC TGATTACTAC AGCCCAACCC GGGCGGACAC CACCACCATT 
CTGGCTGCCG GGGCTGGAGT GACCATAGGA TTCTGGATCA ACCATTTCTT CCAGCTTGTA 
TCCAAGCCCG CTGAATCTCT CCCTGTTATT CAGAACATCC CACCACTCAC CACCTACATG 
TTAGTTTTGG GTCTGACCAA ATTTGCAGTG GGAATTGTGT TGATCCTCTT GGTTCGTCAG 
CTTGTACAAA ATCTCTCACT GCAAGTATTA TACTCATGGT TCAAGGTGGT CACCAGGAAC 
AAGGAGGCCA GGCGGAGACT GGAGATTGAA GTGCCTTACA AGTTTGTTAC CTACACATCT 
GTTGGCATCT GCGCTACAAC CTTTGTGCCG ATGCTTCACA GGTTTCTGGG ATTACCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_689599.2
CDS	97..1296
Translation	MAELLRSLQDSQLVARFQRRCGLFPAPDEGPRENGADPTERAARVPGVEHLPAANGKGGEAPANGLRRAAAPEAYVQKYVVKNYFYYYLFQFSAALGQEVFYITFLPFTHWNIDPYLSRRLIIIWVLVMYIGQVAKDVLKWPRPSSPPVVKLEKRLIAEYGMPSTHAMAATAIAFTLLISTMDRYQYPFVLGLVMAVVFSTLVCLSRLYTGMHTVLDVLGGVLITALLIVLTYPAWTFIDCLDSASPLFPVCVIVVPFFLCYNYPVSDYYSPTRADTTTILAAGAGVTIGFWINHFFQLVSKPAESLPVIQNIPPLTTYMLVLGLTKFAVGIVLILLVRQLVQNLSLQVLYSWFKVVTRNKEARRRLEIEVPYKFVTYTSVGICATTFVPMLHRFLGLP

Target ORF information:

RefSeq Version	NM_152386.3
Organism	Homo sapiens(human)
Definition	Homo sapiens sphingosine-1-phosphate phosphatase 2 (SGPP2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_152386.3

ORF Insert Sequence:

ATGGCCGAGC TGCTGCGGAG CCTGCAGGAT TCCCAGCTCG TCGCCCGCTT CCAGCGCCGC 
TGCGGGCTCT TCCCCGCTCC GGATGAAGGC CCCCGGGAGA ACGGCGCGGA CCCCACGGAG 
CGCGCGGCGC GGGTCCCCGG GGTCGAGCAT CTCCCCGCAG CCAACGGCAA GGGCGGCGAG 
GCTCCGGCCA ACGGGCTGCG CAGAGCCGCG GCGCCGGAGG CTTATGTACA GAAGTACGTC 
GTGAAGAATT ATTTCTACTA TTACCTATTC CAATTTTCAG CTGCTTTGGG CCAAGAAGTG 
TTCTACATCA CGTTTCTTCC ATTCACTCAC TGGAATATTG ACCCTTATTT ATCCAGAAGA 
TTGATCATCA TATGGGTTTT GGTGATGTAT ATTGGCCAAG TGGCCAAGGA TGTCTTGAAG 
TGGCCCCGTC CCTCCTCCCC TCCAGTTGTA AAACTGGAAA AGAGACTGAT CGCTGAATAT 
GGAATGCCAT CCACCCACGC CATGGCGGCC ACTGCCATTG CCTTCACCCT CCTTATCTCT 
ACTATGGACA GATACCAGTA TCCATTTGTG TTGGGACTGG TGATGGCCGT GGTGTTTTCC 
ACCTTGGTGT GTCTCAGCAG GCTCTACACT GGGATGCATA CGGTCCTGGA TGTGCTGGGT 
GGCGTCCTGA TCACCGCACT CCTCATCGTC CTCACCTACC CTGCCTGGAC CTTCATCGAC 
TGCCTGGACT CGGCCAGCCC CCTCTTCCCC GTGTGTGTCA TAGTTGTGCC ATTCTTCCTG 
TGTTACAATT ACCCTGTTTC TGATTACTAC AGCCCAACCC GGGCGGACAC CACCACCATT 
CTGGCTGCCG GGGCTGGAGT GACCATAGGA TTCTGGATCA ACCATTTCTT CCAGCTTGTA 
TCCAAGCCCG CTGAATCTCT CCCTGTTATT CAGAACATCC CACCACTCAC CACCTACATG 
TTAGTTTTGG GTCTGACCAA ATTTGCAGTG GGAATTGTGT TGATCCTCTT GGTTCGTCAG 
CTTGTACAAA ATCTCTCACT GCAAGTATTA TACTCATGGT TCAAGGTGGT CACCAGGAAC 
AAGGAGGCCA GGCGGAGACT GGAGATTGAA GTGCCTTACA AGTTTGTTAC CTACACATCT 
GTTGGCATCT GCGCTACAAC CTTTGTGCCG ATGCTTCACA GGTTTCTGGG ATTACCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Sphingosine-1-phosphate Phosphatase 2 Regulates Pancreatic Islet ?-Cell Endoplasmic Reticulum Stress and Proliferation.
The Journal of biological chemistry291(23)12029-38(2016 Jun)
Taguchi Y,Allende ML,Mizukami H,Cook EK,Gavrilova O,Tuymetova G,Clarke BA,Chen W,Olivera A,Proia RL

Tumor suppressor microRNA-31 inhibits gastric carcinogenesis by targeting Smad4 and SGPP2.
Cancer gene therapy22(12)564-72(2015 Dec)
Ruoming W,Zhen Y,Tengteng Z,Jisheng H

Vitamin D-responsive SGPP2 variants associated with lung cell expression and lung function.
BMC medical genetics14122(2013 Nov)
Reardon BJ,Hansen JG,Crystal RG,Houston DK,Kritchevsky SB,Harris T,Lohman K,Liu Y,O'Connor GT,Wilk JB,Mezey J,Gao C,Cassano PA

Sphingosine pathway deregulation in endometriotic tissues.
Fertility and sterility97(4)904-11(2012 Apr)
Santulli P,Marcellin L,No?l JC,Borghese B,Fayt I,Vaiman D,Chapron C,M?hats C

Sphingosine 1-phosphate phosphatase 2 is induced during inflammatory responses.
Cellular signalling19(4)748-60(2007 Apr)
Mechtcheriakova D,Wlachos A,Sobanov J,Kopp T,Reuschel R,Bornancin F,Cai R,Zemann B,Urtz N,Stingl G,Zlabinger G,Woisetschl?ger M,Baumruker T,Billich A

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SGPP2 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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