NLRP13 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	NLRP13
Entrez Gene ID	126204
Full Name	NLR family pyrin domain containing 13
Synonyms	CLR19.7,NALP13,NOD14,PAN13
General protein information	Preferred Names NLR family pyrin domain containing 13 Names NACHT, LRR and PYD domains-containing protein 13 NACHT, LRR and PYD containing protein 13 NACHT, leucine rich repeat and PYD containing 13 nucleotide-binding oligomerization domain protein 14 nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 13
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 19 Map Location: 19q13.43
Summary	This gene encodes a member of the NACHT, leucine rich repeat, and PYD containing (NLRP) protein family. It has an N-terminal pyrin domain, followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. NLRP proteins are implicated in the activation of proinflammatory caspases through multiprotein complexes called inflammasomes. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2016].
Disorder MIM:	609660

mRNA and Protein(s)

mRNA	Protein	Name
NM_176810.2	NP_789780.2	NACHT, LRR and PYD domains-containing protein 13 isoform 1
NM_001321057.1	NP_001307986.1	NACHT, LRR and PYD domains-containing protein 13 isoform 2

Pathways from BioSystems

Homologies

Homo sapiens (human)	NLRP13	NP_789780.2
	NLRP13	XP_001090672.1
Canis lupus familiaris (dog)	NLRP13	XP_541402.3
Pan troglodytes (chimpanzee)	NLRP13	XP_524405.2
Bos taurus (cattle)	NLRP13	XP_002695512.2

Gene Ontology
Bibliography

Related articles in PubMed

What do we know about the inflammasome in humans?
Amin J, Boche D, Rakic S
Brain pathology (Zurich, Switzerland)27(2)192-204(2017 Mar)

Genome-wide analysis of polymorphisms associated with cytokine responses in smallpox vaccine recipients.
Kennedy RB, Ovsyannikova IG, Pankratz VS, Haralambieva IH, Vierkant RA, Poland GA
Human genetics131(9)1403-21(2012 Sep)

The genetics of NOD-like receptors in Crohn's disease.
Cummings JR, Cooney RM, Clarke G, Beckly J, Geremia A, Pathan S, Hancock L, Guo C, Cardon LR, Jewell DP
Tissue antigens76(1)48-56(2010 Jul)

Genetic variants in apoptosis and immunoregulation-related genes are associated with risk of chronic lymphocytic leukemia.
Enjuanes A, Benavente Y, Bosch F, Mart?n-Guerrero I, Colomer D, P?rez-Alvarez S, Reina O, Ardanaz MT, Jares P, Garc?a-Orad A, Pujana MA, Montserrat E, de Sanjos? S, Campo E
Cancer research68(24)10178-86(2008 Dec)

The NLR gene family: a standard nomenclature.
Ting JP, Lovering RC, Alnemri ES, Bertin J, Boss JM, Davis BK, Flavell RA, Girardin SE, Godzik A, Harton JA, Hoffman HM, Hugot JP, Inohara N, Mackenzie A, Maltais LJ, Nunez G, Ogura Y, Otten LA, Philpott D, Reed JC, Reith W, Schreiber S, Steimle V, Ward PA
Immunity28(3)285-7(2008 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Observational study of gene-disease association. (HuGE Navigator)
Title: The genetics of NOD-like receptors in Crohn's disease.

Observational study of gene-disease association. (HuGE Navigator)
Title: Genetic variants in apoptosis and immunoregulation-related genes are associated with risk of chronic lymphocytic leukemia.

The following NLRP13 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the NLRP13 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu29939	NM_176810.2 Latest version!	Homo sapiens NLR family pyrin domain containing 13 (NLRP13), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	15-17	$559.30 $799.00
OHu52015	NM_001321057.1 Latest version!	Homo sapiens NLR family pyrin domain containing 13 (NLRP13), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	15-17	$559.30 $799.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

NLRP13 ( NM_176810.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_789780.2 Homo sapiens NLR family pyrin domain containing 13 (NLRP13), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu29939
Clone ID Related Accession (Same CDS sequence)	NM_176810.2
Accession Version	NM_176810.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3132bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-26
Organism	Homo sapiens(human)
Product	NACHT, LRR and PYD domains-containing protein 13 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BK001108.1, AY154468.1 and AC012310.5. On Jul 22, 2006 this sequence version replaced NM_176810.1. ##Evidence-Data-START## Transcript exon combination :: AY154468.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1968968, SAMEA2148093 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END##

ATGAACTTTT CTGTAATCAC CTGCCCCAAC GGTGGTACCA ACCAAGGGCT TCTGCCTTAC 
CTGATGGCCC TGGATCAGTA TCAGCTGGAG GAATTCAAGC TTTGCTTGGA ACCCCAGCAG 
CTGATGGACT TCTGGTCGGC CCCCCAGGGG CACTTCCCGC GTATCCCCTG GGCAAACTTG 
AGAGCTGCCG ACCCTTTGAA TCTGTCCTTT CTTTTGGATG AACACTTCCC AAAAGGTCAG 
GCATGGAAAG TGGTCCTCGG CATCTTCCAG ACAATGAATC TGACCTCACT GTGTGAGAAA 
GTTAGAGCCG AGATGAAAGA GAATGTGCAG ACCCAAGAGC TGCAAGATCC AACCCAGGAA 
GATCTAGAGA TGCTAGAAGC AGCAGCAGGG AATATGCAGA CCCAGGGATG CCAAGATCCA 
AACCAAGAAG AACTAGACGA GCTAGAAGAA GAAACAGGGA ATGTACAGGC CCAGGGATGC 
CAAGATCCAA ACCAAGAAGA ACCAGAGATG CTAGAGGAAG CAGACCACAG AAGAAAATAC 
AGAGAGAACA TGAAGGCTGA ACTACTGGAG ACATGGGACA ACATCAGTTG GCCTAAAGAC 
CACGTATATA TCCGTAATAC ATCAAAGGAC GAACATGAGG AACTGCAGCG CCTACTGGAT 
CCTAATAGGA CTAGAGCCCA GGCCCAGACG ATAGTCTTGG TGGGGAGGGC AGGGGTTGGG 
AAGACCACCT TGGCAATGCA GGCTATGCTG CACTGGGCAA ATGGAGTTCT CTTTCAGCAA 
AGGTTCTCCT ATGTTTTCTA TCTCAGCTGC CATAAAATAA GGTACATGAA GGAAACTACC 
TTTGCTGAAT TGATTTCTTT GGATTGGCCC GATTTTGATG CCCCCATTGA AGAGTTCATG 
TCTCAACCAG AGAAGCTCCT GTTTATTATT GATGGCTTTG AGGAAATAAT CATATCTGAG 
TCACGCTCTG AGAGCTTGGA TGATGGCTCG CCATGTACAG ACTGGTACCA GGAGCTCCCA 
GTGACCAAAA TCCTACACAG CTTGTTGAAG AAAGAATTGG TTCCCCTGGC TACCTTACTG 
ATCACGATCA AGACCTGGTT TGTGAGAGAT CTTAAGGCCT CATTAGTGAA TCCATGCTTT 
GTACAAATTA CAGGGTTCAC AGGGGACGAC CTACGGGTAT ATTTCATGAG ACACTTTGAT 
GACTCAAGTG AAGTTGAGAA AATCCTGCAG CAGCTAAGAA AAAACGAAAC TCTCTTTCAT 
TCCTGCAGTG CCCCCATGGT GTGTTGGACC GTATGTTCCT GTCTGAAGCA GCCGAAGGTG 
AGGTATTACG ATCTCCAGTC AATCACTCAG ACTACCACCA GTCTGTATGC CTATTTTTTC 
TCCAACTTGT TCTCCACAGC AGAGGTAGAT TTGGCAGATG ACAGCTGGCC AGGACAATGG 
AGGGCCCTCT GCAGTCTGGC CATAGAAGGG CTGTGGTCTA TGAACTTCAC GTTTAACAAA 
GAAGACACTG AGATCGAGGG CCTGGAAGTG CCTTTCATTG ATTCTCTCTA CGAGTTCAAT 
ATTCTTCAAA AGATCAATGA CTGTGGGGGT TGCACTACTT TCACCCACCT AAGTTTCCAG 
GAGTTTTTTG CAGCCATGTC CTTTGTGCTA GAGGAACCTA GAGAATTCCC TCCCCATTCC 
ACAAAGCCAC AAGAGATGAA GATGTTACTG CAACACGTCT TGCTTGACAA AGAAGCCTAC 
TGGACTCCAG TGGTTCTGTT CTTCTTTGGT CTTTTAAATA AAAACATAGC AAGAGAACTG 
GAAGATACTT TGCATTGTAA AATATCTCCC AGGGTAATGG AGGAATTATT AAAGTGGGGA 
GAAGAGTTAG GTAAGGCTGA AAGTGCCTCT CTCCAATTTC ACATTCTACG ACTTTTTCAC 
TGCCTACACG AGTCCCAGGA GGAAGACTTC ACAAAGAAGA TGTTGGGTCG TATCTTTGAA 
GTTGACCTTA ATATTTTGGA GGACGAAGAA CTCCAAGCTT CTTCATTTTG CCTAAAGCAC 
TGTAAAAGGT TAAATAAGCT AAGGCTTTCT GTTAGCAGTC ACATCCTTGA AAGGGACTTG 
GAAATTCTGG AGACAAGCAA GTTTGATTCC AGGATGCACG CATGGAACAG CATTTGCTCT 
ACGTTGGTCA CAAATGAGAA TCTGCATGAG CTAGACCTGA GTAACAGCAA ACTTCATGCT 
TCCTCTGTGA AGGGTCTCTG TCTTGCACTG AAAAATCCAA GATGCAAAGT CCAGAAACTG 
ACGTGCAAAT CGGTAACTCC TGAGTGGGTT CTGCAGGACC TCATTATTGC CCTTCAGGGT 
AACAGCAAGC TGACCCATCT GAACTTCAGC TCTAACAAGC TGGGAATGAC TGTCCCCCTG 
ATTCTTAAAG CTTTGAGACA CTCAGCTTGC AACCTCAAGT ATCTGTGCCT GGAGAAATGC 
AACTTGTCGG CAGCCAGCTG TCAGGACCTA GCCTTGTTTC TCACCAGCAT CCAACACGTA 
ACTCGATTGT GCCTGGGATT TAATCGGCTC CAAGATGATG GCATAAAGCT ATTGTGTGCG 
GCCCTGACTC ACCCCAAGTG TGCCTTAGAG AGACTGGAGC TCTGGTTTTG CCAGCTGGCA 
GCACCCGCTT GCAAGCACTT GTCAGATGCT CTCCTGCAGA ACAGGAGCCT GACACACCTG 
AATCTGAGCA AGAACAGCCT GAGAGACGAG GGAGTCAAGT TCCTGTGTGA GGCCTTGGGT 
CGCCCAGATG GTAACCTGCA GAGCCTGAAT TTGTCAGGTT GTTCTTTCAC AAGAGAGGGC 
TGTGGAGAGC TGGCTAATGC CCTCAGCCAT AATCATAATG TGAAAATCTT GGATTTGGGA 
GAAAATGATC TTCAGGATGA TGGAGTGAAG CTACTGTGTG AGGCTCTGAA ACCACATCGT 
GCATTGCACA CACTTGGGTT GGCGAAATGC AATCTGACAA CTGCTTGCTG CCAGCATCTC 
TTCTCTGTTC TCAGCAGCAG TAAGAGCCTG GTCAATCTGA ACCTTCTAGG CAATGAATTG 
GATACTGATG GTGTCAAGAT GCTATGTAAG GCTTTGAAAA AGTCGACATG CAGGCTGCAG 
AAACTCGGGT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_789780.2
CDS	26..3157
Translation	MNFSVITCPNGGTNQGLLPYLMALDQYQLEEFKLCLEPQQLMDFWSAPQGHFPRIPWANLRAADPLNLSFLLDEHFPKGQAWKVVLGIFQTMNLTSLCEKVRAEMKENVQTQELQDPTQEDLEMLEAAAGNMQTQGCQDPNQEELDELEEETGNVQAQGCQDPNQEEPEMLEEADHRRKYRENMKAELLETWDNISWPKDHVYIRNTSKDEHEELQRLLDPNRTRAQAQTIVLVGRAGVGKTTLAMQAMLHWANGVLFQQRFSYVFYLSCHKIRYMKETTFAELISLDWPDFDAPIEEFMSQPEKLLFIIDGFEEIIISESRSESLDDGSPCTDWYQELPVTKILHSLLKKELVPLATLLITIKTWFVRDLKASLVNPCFVQITGFTGDDLRVYFMRHFDDSSEVEKILQQLRKNETLFHSCSAPMVCWTVCSCLKQPKVRYYDLQSITQTTTSLYAYFFSNLFSTAEVDLADDSWPGQWRALCSLAIEGLWSMNFTFNKEDTEIEGLEVPFIDSLYEFNILQKINDCGGCTTFTHLSFQEFFAAMSFVLEEPREFPPHSTKPQEMKMLLQHVLLDKEAYWTPVVLFFFGLLNKNIARELEDTLHCKISPRVMEELLKWGEELGKAESASLQFHILRLFHCLHESQEEDFTKKMLGRIFEVDLNILEDEELQASSFCLKHCKRLNKLRLSVSSHILERDLEILETSKFDSRMHAWNSICSTLVTNENLHELDLSNSKLHASSVKGLCLALKNPRCKVQKLTCKSVTPEWVLQDLIIALQGNSKLTHLNFSSNKLGMTVPLILKALRHSACNLKYLCLEKCNLSAASCQDLALFLTSIQHVTRLCLGFNRLQDDGIKLLCAALTHPKCALERLELWFCQLAAPACKHLSDALLQNRSLTHLNLSKNSLRDEGVKFLCEALGRPDGNLQSLNLSGCSFTREGCGELANALSHNHNVKILDLGENDLQDDGVKLLCEALKPHRALHTLGLAKCNLTTACCQHLFSVLSSSKSLVNLNLLGNELDTDGVKMLCKALKKSTCRLQKLG

Target ORF information:

RefSeq Version	NM_176810.2
Organism	Homo sapiens(human)
Definition	Homo sapiens NLR family pyrin domain containing 13 (NLRP13), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_176810.2

ORF Insert Sequence:

ATGAACTTTT CTGTAATCAC CTGCCCCAAC GGTGGTACCA ACCAAGGGCT TCTGCCTTAC 
CTGATGGCCC TGGATCAGTA TCAGCTGGAG GAATTCAAGC TTTGCTTGGA ACCCCAGCAG 
CTGATGGACT TCTGGTCGGC CCCCCAGGGG CACTTCCCGC GTATCCCCTG GGCAAACTTG 
AGAGCTGCCG ACCCTTTGAA TCTGTCCTTT CTTTTGGATG AACACTTCCC AAAAGGTCAG 
GCATGGAAAG TGGTCCTCGG CATCTTCCAG ACAATGAATC TGACCTCACT GTGTGAGAAA 
GTTAGAGCCG AGATGAAAGA GAATGTGCAG ACCCAAGAGC TGCAAGATCC AACCCAGGAA 
GATCTAGAGA TGCTAGAAGC AGCAGCAGGG AATATGCAGA CCCAGGGATG CCAAGATCCA 
AACCAAGAAG AACTAGACGA GCTAGAAGAA GAAACAGGGA ATGTACAGGC CCAGGGATGC 
CAAGATCCAA ACCAAGAAGA ACCAGAGATG CTAGAGGAAG CAGACCACAG AAGAAAATAC 
AGAGAGAACA TGAAGGCTGA ACTACTGGAG ACATGGGACA ACATCAGTTG GCCTAAAGAC 
CACGTATATA TCCGTAATAC ATCAAAGGAC GAACATGAGG AACTGCAGCG CCTACTGGAT 
CCTAATAGGA CTAGAGCCCA GGCCCAGACG ATAGTCTTGG TGGGGAGGGC AGGGGTTGGG 
AAGACCACCT TGGCAATGCA GGCTATGCTG CACTGGGCAA ATGGAGTTCT CTTTCAGCAA 
AGGTTCTCCT ATGTTTTCTA TCTCAGCTGC CATAAAATAA GGTACATGAA GGAAACTACC 
TTTGCTGAAT TGATTTCTTT GGATTGGCCC GATTTTGATG CCCCCATTGA AGAGTTCATG 
TCTCAACCAG AGAAGCTCCT GTTTATTATT GATGGCTTTG AGGAAATAAT CATATCTGAG 
TCACGCTCTG AGAGCTTGGA TGATGGCTCG CCATGTACAG ACTGGTACCA GGAGCTCCCA 
GTGACCAAAA TCCTACACAG CTTGTTGAAG AAAGAATTGG TTCCCCTGGC TACCTTACTG 
ATCACGATCA AGACCTGGTT TGTGAGAGAT CTTAAGGCCT CATTAGTGAA TCCATGCTTT 
GTACAAATTA CAGGGTTCAC AGGGGACGAC CTACGGGTAT ATTTCATGAG ACACTTTGAT 
GACTCAAGTG AAGTTGAGAA AATCCTGCAG CAGCTAAGAA AAAACGAAAC TCTCTTTCAT 
TCCTGCAGTG CCCCCATGGT GTGTTGGACC GTATGTTCCT GTCTGAAGCA GCCGAAGGTG 
AGGTATTACG ATCTCCAGTC AATCACTCAG ACTACCACCA GTCTGTATGC CTATTTTTTC 
TCCAACTTGT TCTCCACAGC AGAGGTAGAT TTGGCAGATG ACAGCTGGCC AGGACAATGG 
AGGGCCCTCT GCAGTCTGGC CATAGAAGGG CTGTGGTCTA TGAACTTCAC GTTTAACAAA 
GAAGACACTG AGATCGAGGG CCTGGAAGTG CCTTTCATTG ATTCTCTCTA CGAGTTCAAT 
ATTCTTCAAA AGATCAATGA CTGTGGGGGT TGCACTACTT TCACCCACCT AAGTTTCCAG 
GAGTTTTTTG CAGCCATGTC CTTTGTGCTA GAGGAACCTA GAGAATTCCC TCCCCATTCC 
ACAAAGCCAC AAGAGATGAA GATGTTACTG CAACACGTCT TGCTTGACAA AGAAGCCTAC 
TGGACTCCAG TGGTTCTGTT CTTCTTTGGT CTTTTAAATA AAAACATAGC AAGAGAACTG 
GAAGATACTT TGCATTGTAA AATATCTCCC AGGGTAATGG AGGAATTATT AAAGTGGGGA 
GAAGAGTTAG GTAAGGCTGA AAGTGCCTCT CTCCAATTTC ACATTCTACG ACTTTTTCAC 
TGCCTACACG AGTCCCAGGA GGAAGACTTC ACAAAGAAGA TGTTGGGTCG TATCTTTGAA 
GTTGACCTTA ATATTTTGGA GGACGAAGAA CTCCAAGCTT CTTCATTTTG CCTAAAGCAC 
TGTAAAAGGT TAAATAAGCT AAGGCTTTCT GTTAGCAGTC ACATCCTTGA AAGGGACTTG 
GAAATTCTGG AGACAAGCAA GTTTGATTCC AGGATGCACG CATGGAACAG CATTTGCTCT 
ACGTTGGTCA CAAATGAGAA TCTGCATGAG CTAGACCTGA GTAACAGCAA ACTTCATGCT 
TCCTCTGTGA AGGGTCTCTG TCTTGCACTG AAAAATCCAA GATGCAAAGT CCAGAAACTG 
ACGTGCAAAT CGGTAACTCC TGAGTGGGTT CTGCAGGACC TCATTATTGC CCTTCAGGGT 
AACAGCAAGC TGACCCATCT GAACTTCAGC TCTAACAAGC TGGGAATGAC TGTCCCCCTG 
ATTCTTAAAG CTTTGAGACA CTCAGCTTGC AACCTCAAGT ATCTGTGCCT GGAGAAATGC 
AACTTGTCGG CAGCCAGCTG TCAGGACCTA GCCTTGTTTC TCACCAGCAT CCAACACGTA 
ACTCGATTGT GCCTGGGATT TAATCGGCTC CAAGATGATG GCATAAAGCT ATTGTGTGCG 
GCCCTGACTC ACCCCAAGTG TGCCTTAGAG AGACTGGAGC TCTGGTTTTG CCAGCTGGCA 
GCACCCGCTT GCAAGCACTT GTCAGATGCT CTCCTGCAGA ACAGGAGCCT GACACACCTG 
AATCTGAGCA AGAACAGCCT GAGAGACGAG GGAGTCAAGT TCCTGTGTGA GGCCTTGGGT 
CGCCCAGATG GTAACCTGCA GAGCCTGAAT TTGTCAGGTT GTTCTTTCAC AAGAGAGGGC 
TGTGGAGAGC TGGCTAATGC CCTCAGCCAT AATCATAATG TGAAAATCTT GGATTTGGGA 
GAAAATGATC TTCAGGATGA TGGAGTGAAG CTACTGTGTG AGGCTCTGAA ACCACATCGT 
GCATTGCACA CACTTGGGTT GGCGAAATGC AATCTGACAA CTGCTTGCTG CCAGCATCTC 
TTCTCTGTTC TCAGCAGCAG TAAGAGCCTG GTCAATCTGA ACCTTCTAGG CAATGAATTG 
GATACTGATG GTGTCAAGAT GCTATGTAAG GCTTTGAAAA AGTCGACATG CAGGCTGCAG 
AAACTCGGGT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

NLRP13 ( NM_001321057.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001307986.1 Homo sapiens NLR family pyrin domain containing 13 (NLRP13), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu52015
Clone ID Related Accession (Same CDS sequence)	NM_001321057.1
Accession Version	NM_001321057.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3111bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-29
Organism	Homo sapiens(human)
Product	NACHT, LRR and PYD domains-containing protein 13 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BK001108.1 and AY154468.1. This sequence is a reference standard in the RefSeqGene project. On Mar 18, 2016 this sequence version replaced XM_005258510.1. ##Evidence-Data-START## Transcript exon combination :: BK001108.1 [ECO:0000332] ##Evidence-Data-END##

ATGAACTTTT CTGTAATCAC CTGCCCCAAC GGTGGTACCA ACCAAGGGCT TCTGCCTTAC 
CTGATGGCCC TGGATCAGTA TCAGCTGGAG GAATTCAAGC TTTGCTTGGA ACCCCAGCAG 
CTGATGGACT TCTGGTCGGC CCCCCAGGGG CACTTCCCGC GTATCCCCTG GGCAAACTTG 
AGAGCTGCCG ACCCTTTGAA TCTGTCCTTT CTTTTGGATG AACACTTCCC AAAAGGTCAG 
GCATGGAAAG TGGTCCTCGG CATCTTCCAG ACAATGAATC TGACCTCACT GTGTGAGAAA 
GTTAGAGCCG AGATGAAAGA GAATGTGCAG ACCCAAGAGC TGCAAGATCC AACCCAGGAA 
GATCTAGAGA TGCTAGAAGC AGCAGCAGGG AATATGCAGA CCCAGGGATG CCAAGATCCA 
AACCAAGAAG AACTAGACGA GCTAGAAGAA GAAACAGGGA ATGTACAGGC CCAGGGATGC 
CAAGATCCAA ACCAAGAAGA ACCAGAGATG CTAGAGGAAG CAGACCACAG AAGAAAATAC 
AGAGAGAACA TGAAGGCTGA ACTACTGGAG ACATGGGACA ACATCAGTTG GCCTAAAGAC 
CACGTATATA TCCGTAATAC ATCAAAGGAC GAACATGAGG AACTGCAGCG CCTACTGGAT 
CCTAATAGGA CTAGAGCCCA GGCCCAGACG ATAGTCTTGG TGGGGAGGGC AGGGGTTGGG 
AAGACCACCT TGGCAATGCA GGCTATGCTG CACTGGGCAA ATGGAGTTCT CTTTCAGCAA 
AGGTTCTCCT ATGTTTTCTA TCTCAGCTGC CATAAAATAA GGTACATGAA GGAAACTACC 
TTTGCTGAAT TGATTTCTTT GGATTGGCCC GATTTTGATG CCCCCATTGA AGAGTTCATG 
TCTCAACCAG AGAAGCTCCT GTTTATTATT GATGGCTTTG AGGAAATAAT CATATCTGAG 
TCACGCTCTG AGAGCTTGGA TGATGGCTCG CCATGTACAG ACTGGTACCA GGAGCTCCCA 
GTGACCAAAA TCCTACACAG CTTGTTGAAG AAAGAATTGG TTCCCCTGGC TACCTTACTG 
ATCACGATCA AGACCTGGTT TGTGAGAGAT CTTAAGGCCT CATTAGTGAA TCCATGCTTT 
GTACAAATTA CAGGGTTCAC AGGGGACGAC CTACGGGTAT ATTTCATGAG ACACTTTGAT 
GACTCAAGTG AAGTTGAGAA AATCCTGCAG CAGCTAAGAA AAAACGAAAC TCTCTTTCAT 
TCCTGCAGTG CCCCCATGGT GTGTTGGACC GTATGTTCCT GTCTGAAGCA GCCGAAGGTG 
AGGTATTACG ATCTCCAGTC AATCACTCAG ACTACCACCA GTCTGTATGC CTATTTTTTC 
TCCAACTTGT TCTCCACAGC AGAGGTAGAT TTGGCAGATG ACAGCTGGCC AGGACAATGG 
AGGGCCCTCT GCAGTCTGGC CATAGAAGGG CTGTGGTCTA TGAACTTCAC GTTTAACAAA 
GAAGACACTG AGATCGAGGG CCTGGAAGTG CCTTTCATTG ATTCTCTCTA CGAGTTCAAT 
ATTCTTCAAA AGATCAATGA CTGTGGGGGT TGCACTACTT TCACCCACCT AAGTTTCCAG 
GAGTTTTTTG CAGCCATGTC CTTTGTGCTA GAGGAACCTA GAGAATTCCC TCCCCATTCC 
ACAAAGCCAC AAGAGATGAA GATGTTACTG CAACACGTCT TGCTTGACAA AGAAGCCTAC 
TGGACTCCAG TGGTTCTGTT CTTCTTTGGT CTTTTAAATA AAAACATAGC AAGAGAACTG 
GAAGATACTT TGCATTGTAA AATATCTCCC AGGGTAATGG AGGAATTATT AAAGTGGGGA 
GAAGAGTTAG GTAAGGCTGA AAGTGCCTCT CTCCAATTTC ACATTCTACG ACTTTTTCAC 
TGCCTACACG AGTCCCAGGA GGAAGACTTC ACAAAGAAGA TGTTGGGTCG TATCTTTGAA 
GTTGACCTTA ATATTTTGGA GGACGAAGAA CTCCAAGCTT CTTCATTTTG CCTAAAGCAC 
TGTAAAAGGT TAAATAAGCT AAGGCTTTCT GTTAGCAGTC ACATCCTTGA AAGGGACTTG 
GAAATTCTGG AGACAAGCAA GTTTGATTCC AGGATGCACG CATGGAACAG CATTTGCTCT 
ACGTTGGTCA CAAATGAGAA TCTGCATGAG CTAGACCTGA GTAACAGCAA ACTTCATGCT 
TCCTCTGTGA AGGGTCTCTG TCTTGCACTG AAAAATCCAA GATGCAAAGT CCAGAAACTG 
ACGTGCAAAT CGGTAACTCC TGAGTGGGTT CTGCAGGACC TCATTATTGC CCTTCAGGGT 
AACAGCAAGC TGACCCATCT GAACTTCAGC TCTAACAAGC TGGGAATGAC TGTCCCCCTG 
ATTCTTAAAG CTTTGAGACA CTCAGCTTGC AACCTCAAGT ATCTGTGCCT GGAGAAATGC 
AACTTGTCGG CAGCCAGCTG TCAGGACCTA GCCTTGTTTC TCACCAGCAT CCAACACGTA 
ACTCGATTGT GCCTGGGATT TAATCGGCTC CAAGATGATG GCATAAAGCT ATTGTGTGCG 
GCCCTGACTC ACCCCAAGTG TGCCTTAGAG AGACTGGAGC TCTGGTTTTG CCAGCTGGCA 
GCACCCGCTT GCAAGCACTT GTCAGATGCT CTCCTGCAGA ACAGGAGCCT GACACACCTG 
AATCTGAGCA AGAACAGCCT GAGAGACGAG GGAGTCAAGT TCCTGTGTGA GGCCTTGGGT 
CGCCCAGATG GTAACCTGCA GAGCCTGAAT TTGTCAGGTT GTTCTTTCAC AAGAGAGGGC 
TGTGGAGAGC TGGCTAATGC CCTCAGCCAT AATCATAATG TGAAAATCTT GGATTTGGGA 
GAAAATGATC TTCAGGATGA TGGAGTGAAG CTACTGTGTG AGGCTCTGAA ACCACATCGT 
GCATTGCACA CACTTGGGTT GGCGAAATGC AATCTGACAA CTGCTTGCTG CCAGCATCTC 
TTCTCTGTTC TCAGCAGCAG TAAGAGCCTG GTCAATCTGA ACCTTCTAGG CAATGAATTG 
GATACTGATG GTGTCAAGAT GCTATGCTTC AAAAAGACCT GCACAATGTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001307986.1
CDS	26..3136
Translation	MNFSVITCPNGGTNQGLLPYLMALDQYQLEEFKLCLEPQQLMDFWSAPQGHFPRIPWANLRAADPLNLSFLLDEHFPKGQAWKVVLGIFQTMNLTSLCEKVRAEMKENVQTQELQDPTQEDLEMLEAAAGNMQTQGCQDPNQEELDELEEETGNVQAQGCQDPNQEEPEMLEEADHRRKYRENMKAELLETWDNISWPKDHVYIRNTSKDEHEELQRLLDPNRTRAQAQTIVLVGRAGVGKTTLAMQAMLHWANGVLFQQRFSYVFYLSCHKIRYMKETTFAELISLDWPDFDAPIEEFMSQPEKLLFIIDGFEEIIISESRSESLDDGSPCTDWYQELPVTKILHSLLKKELVPLATLLITIKTWFVRDLKASLVNPCFVQITGFTGDDLRVYFMRHFDDSSEVEKILQQLRKNETLFHSCSAPMVCWTVCSCLKQPKVRYYDLQSITQTTTSLYAYFFSNLFSTAEVDLADDSWPGQWRALCSLAIEGLWSMNFTFNKEDTEIEGLEVPFIDSLYEFNILQKINDCGGCTTFTHLSFQEFFAAMSFVLEEPREFPPHSTKPQEMKMLLQHVLLDKEAYWTPVVLFFFGLLNKNIARELEDTLHCKISPRVMEELLKWGEELGKAESASLQFHILRLFHCLHESQEEDFTKKMLGRIFEVDLNILEDEELQASSFCLKHCKRLNKLRLSVSSHILERDLEILETSKFDSRMHAWNSICSTLVTNENLHELDLSNSKLHASSVKGLCLALKNPRCKVQKLTCKSVTPEWVLQDLIIALQGNSKLTHLNFSSNKLGMTVPLILKALRHSACNLKYLCLEKCNLSAASCQDLALFLTSIQHVTRLCLGFNRLQDDGIKLLCAALTHPKCALERLELWFCQLAAPACKHLSDALLQNRSLTHLNLSKNSLRDEGVKFLCEALGRPDGNLQSLNLSGCSFTREGCGELANALSHNHNVKILDLGENDLQDDGVKLLCEALKPHRALHTLGLAKCNLTTACCQHLFSVLSSSKSLVNLNLLGNELDTDGVKMLCFKKTCTM

Target ORF information:

RefSeq Version	NM_001321057.1
Organism	Homo sapiens(human)
Definition	Homo sapiens NLR family pyrin domain containing 13 (NLRP13), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001321057.1

ORF Insert Sequence:

ATGAACTTTT CTGTAATCAC CTGCCCCAAC GGTGGTACCA ACCAAGGGCT TCTGCCTTAC 
CTGATGGCCC TGGATCAGTA TCAGCTGGAG GAATTCAAGC TTTGCTTGGA ACCCCAGCAG 
CTGATGGACT TCTGGTCGGC CCCCCAGGGG CACTTCCCGC GTATCCCCTG GGCAAACTTG 
AGAGCTGCCG ACCCTTTGAA TCTGTCCTTT CTTTTGGATG AACACTTCCC AAAAGGTCAG 
GCATGGAAAG TGGTCCTCGG CATCTTCCAG ACAATGAATC TGACCTCACT GTGTGAGAAA 
GTTAGAGCCG AGATGAAAGA GAATGTGCAG ACCCAAGAGC TGCAAGATCC AACCCAGGAA 
GATCTAGAGA TGCTAGAAGC AGCAGCAGGG AATATGCAGA CCCAGGGATG CCAAGATCCA 
AACCAAGAAG AACTAGACGA GCTAGAAGAA GAAACAGGGA ATGTACAGGC CCAGGGATGC 
CAAGATCCAA ACCAAGAAGA ACCAGAGATG CTAGAGGAAG CAGACCACAG AAGAAAATAC 
AGAGAGAACA TGAAGGCTGA ACTACTGGAG ACATGGGACA ACATCAGTTG GCCTAAAGAC 
CACGTATATA TCCGTAATAC ATCAAAGGAC GAACATGAGG AACTGCAGCG CCTACTGGAT 
CCTAATAGGA CTAGAGCCCA GGCCCAGACG ATAGTCTTGG TGGGGAGGGC AGGGGTTGGG 
AAGACCACCT TGGCAATGCA GGCTATGCTG CACTGGGCAA ATGGAGTTCT CTTTCAGCAA 
AGGTTCTCCT ATGTTTTCTA TCTCAGCTGC CATAAAATAA GGTACATGAA GGAAACTACC 
TTTGCTGAAT TGATTTCTTT GGATTGGCCC GATTTTGATG CCCCCATTGA AGAGTTCATG 
TCTCAACCAG AGAAGCTCCT GTTTATTATT GATGGCTTTG AGGAAATAAT CATATCTGAG 
TCACGCTCTG AGAGCTTGGA TGATGGCTCG CCATGTACAG ACTGGTACCA GGAGCTCCCA 
GTGACCAAAA TCCTACACAG CTTGTTGAAG AAAGAATTGG TTCCCCTGGC TACCTTACTG 
ATCACGATCA AGACCTGGTT TGTGAGAGAT CTTAAGGCCT CATTAGTGAA TCCATGCTTT 
GTACAAATTA CAGGGTTCAC AGGGGACGAC CTACGGGTAT ATTTCATGAG ACACTTTGAT 
GACTCAAGTG AAGTTGAGAA AATCCTGCAG CAGCTAAGAA AAAACGAAAC TCTCTTTCAT 
TCCTGCAGTG CCCCCATGGT GTGTTGGACC GTATGTTCCT GTCTGAAGCA GCCGAAGGTG 
AGGTATTACG ATCTCCAGTC AATCACTCAG ACTACCACCA GTCTGTATGC CTATTTTTTC 
TCCAACTTGT TCTCCACAGC AGAGGTAGAT TTGGCAGATG ACAGCTGGCC AGGACAATGG 
AGGGCCCTCT GCAGTCTGGC CATAGAAGGG CTGTGGTCTA TGAACTTCAC GTTTAACAAA 
GAAGACACTG AGATCGAGGG CCTGGAAGTG CCTTTCATTG ATTCTCTCTA CGAGTTCAAT 
ATTCTTCAAA AGATCAATGA CTGTGGGGGT TGCACTACTT TCACCCACCT AAGTTTCCAG 
GAGTTTTTTG CAGCCATGTC CTTTGTGCTA GAGGAACCTA GAGAATTCCC TCCCCATTCC 
ACAAAGCCAC AAGAGATGAA GATGTTACTG CAACACGTCT TGCTTGACAA AGAAGCCTAC 
TGGACTCCAG TGGTTCTGTT CTTCTTTGGT CTTTTAAATA AAAACATAGC AAGAGAACTG 
GAAGATACTT TGCATTGTAA AATATCTCCC AGGGTAATGG AGGAATTATT AAAGTGGGGA 
GAAGAGTTAG GTAAGGCTGA AAGTGCCTCT CTCCAATTTC ACATTCTACG ACTTTTTCAC 
TGCCTACACG AGTCCCAGGA GGAAGACTTC ACAAAGAAGA TGTTGGGTCG TATCTTTGAA 
GTTGACCTTA ATATTTTGGA GGACGAAGAA CTCCAAGCTT CTTCATTTTG CCTAAAGCAC 
TGTAAAAGGT TAAATAAGCT AAGGCTTTCT GTTAGCAGTC ACATCCTTGA AAGGGACTTG 
GAAATTCTGG AGACAAGCAA GTTTGATTCC AGGATGCACG CATGGAACAG CATTTGCTCT 
ACGTTGGTCA CAAATGAGAA TCTGCATGAG CTAGACCTGA GTAACAGCAA ACTTCATGCT 
TCCTCTGTGA AGGGTCTCTG TCTTGCACTG AAAAATCCAA GATGCAAAGT CCAGAAACTG 
ACGTGCAAAT CGGTAACTCC TGAGTGGGTT CTGCAGGACC TCATTATTGC CCTTCAGGGT 
AACAGCAAGC TGACCCATCT GAACTTCAGC TCTAACAAGC TGGGAATGAC TGTCCCCCTG 
ATTCTTAAAG CTTTGAGACA CTCAGCTTGC AACCTCAAGT ATCTGTGCCT GGAGAAATGC 
AACTTGTCGG CAGCCAGCTG TCAGGACCTA GCCTTGTTTC TCACCAGCAT CCAACACGTA 
ACTCGATTGT GCCTGGGATT TAATCGGCTC CAAGATGATG GCATAAAGCT ATTGTGTGCG 
GCCCTGACTC ACCCCAAGTG TGCCTTAGAG AGACTGGAGC TCTGGTTTTG CCAGCTGGCA 
GCACCCGCTT GCAAGCACTT GTCAGATGCT CTCCTGCAGA ACAGGAGCCT GACACACCTG 
AATCTGAGCA AGAACAGCCT GAGAGACGAG GGAGTCAAGT TCCTGTGTGA GGCCTTGGGT 
CGCCCAGATG GTAACCTGCA GAGCCTGAAT TTGTCAGGTT GTTCTTTCAC AAGAGAGGGC 
TGTGGAGAGC TGGCTAATGC CCTCAGCCAT AATCATAATG TGAAAATCTT GGATTTGGGA 
GAAAATGATC TTCAGGATGA TGGAGTGAAG CTACTGTGTG AGGCTCTGAA ACCACATCGT 
GCATTGCACA CACTTGGGTT GGCGAAATGC AATCTGACAA CTGCTTGCTG CCAGCATCTC 
TTCTCTGTTC TCAGCAGCAG TAAGAGCCTG GTCAATCTGA ACCTTCTAGG CAATGAATTG 
GATACTGATG GTGTCAAGAT GCTATGCTTC AAAAAGACCT GCACAATGTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

What do we know about the inflammasome in humans?
Brain pathology (Zurich, Switzerland)27(2)192-204(2017 Mar)
Amin J,Boche D,Rakic S

Genome-wide analysis of polymorphisms associated with cytokine responses in smallpox vaccine recipients.
Human genetics131(9)1403-21(2012 Sep)
Kennedy RB,Ovsyannikova IG,Pankratz VS,Haralambieva IH,Vierkant RA,Poland GA

The genetics of NOD-like receptors in Crohn's disease.
Tissue antigens76(1)48-56(2010 Jul)
Cummings JR,Cooney RM,Clarke G,Beckly J,Geremia A,Pathan S,Hancock L,Guo C,Cardon LR,Jewell DP

Genetic variants in apoptosis and immunoregulation-related genes are associated with risk of chronic lymphocytic leukemia.
Cancer research68(24)10178-86(2008 Dec)
Enjuanes A,Benavente Y,Bosch F,Mart?n-Guerrero I,Colomer D,P?rez-Alvarez S,Reina O,Ardanaz MT,Jares P,Garc?a-Orad A,Pujana MA,Montserrat E,de Sanjos? S,Campo E

The NLR gene family: a standard nomenclature.
Immunity28(3)285-7(2008 Mar)
Ting JP,Lovering RC,Alnemri ES,Bertin J,Boss JM,Davis BK,Flavell RA,Girardin SE,Godzik A,Harton JA,Hoffman HM,Hugot JP,Inohara N,Mackenzie A,Maltais LJ,Nunez G,Ogura Y,Otten LA,Philpott D,Reed JC,Reith W,Schreiber S,Steimle V,Ward PA

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NLRP13 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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