| Gene Symbol | CISH |
| Entrez Gene ID | 1154 |
| Full Name | cytokine inducible SH2 containing protein |
| Synonyms | BACTS2,CIS,CIS-1,G18,SOCS |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Homo sapiens(human) |
| Genome | |
| Summary | The protein encoded by this gene contains a SH2 domain and a SOCS box domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by IL2, IL3, GM-CSF and EPO in hematopoietic cells. Proteasome-mediated degradation of this protein has been shown to be involved in the inactivation of the erythropoietin receptor. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]. |
| Disorder MIM: | |
| Disorder Html: | {Tuberculosis, susceptibility to}, 607948 (3); {Malaria, susceptibility to}, 611162 (3); {Bacteremia, susceptibility to}, 614383 (3) |








































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