OMA1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	OMA1
Entrez Gene ID	115209
Full Name	OMA1 zinc metallopeptidase
Synonyms	2010001O09Rik,DAB1,MPRP-1,MPRP1,YKR087C,ZMPOMA1,peptidase
General protein information	Preferred Names OMA1 zinc metallopeptidase Names metalloendopeptidase OMA1, mitochondrial OMA1 homolog, zinc metallopeptidase OMA1 zinc metallopeptidase homolog metalloprotease-related protein 1 overlapping activity with M-AAA protease overlapping with the m-AAA protease 1 homolog zinc metallopeptidase OMA1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 1 Map Location: 1p32.2-p32.1
Disorder MIM:	617081

mRNA and Protein(s)

mRNA	Protein	Name
NM_145243.5	NP_660286.1	metalloendopeptidase OMA1, mitochondrial precursor
NM_145243.4	NP_660286.1	metalloendopeptidase OMA1, mitochondrial precursor

Pathways from BioSystems

Homologies

	OMA1	XP_001114508.2
Canis lupus familiaris (dog)	OMA1	XP_546689.2
Mus musculus (house mouse)	Oma1	NP_080185.1
Homo sapiens (human)	OMA1	NP_660286.1
Gallus gallus (chicken)	OMA1	XP_422503.3
Xenopus tropicalis (tropical clawed frog)	oma1	XP_004914007.1
Bos taurus (cattle)	OMA1	NP_001030205.1
Schizosaccharomyces pombe (fission yeast)	oma1	NP_593540.1
Magnaporthe oryzae (rice blast fungus)	MGG_07052	XP_003715231.1
Rattus norvegicus (Norway rat)	Oma1	NP_001100139.1
Kluyveromyces lactis	KLLA0A07711g	XP_451343.1
Danio rerio (zebrafish)	LOC100331186	XP_002665718.3
Saccharomyces cerevisiae (baker's yeast)	OMA1	NP_013013.2

Gene Ontology
Bibliography

Related articles in PubMed

Reciprocal Degradation of YME1L and OMA1 Adapts Mitochondrial Proteolytic Activity during Stress.
Rainbolt TK, Lebeau J, Puchades C, Wiseman RL
Cell reports14(9)2041-2049(2016 Mar)

C11orf83, a mitochondrial cardiolipin-binding protein involved in bc1 complex assembly and supercomplex stabilization.
Desmurs M, Foti M, Raemy E, Vaz FM, Martinou JC, Bairoch A, Lane L
Molecular and cellular biology35(7)1139-56(2015 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

differential stress-induced degradation of YME1L and OMA1 as a mechanism for sensitively adapting mitochondrial inner membrane protease activity and function in response to distinct types of cellular insults.
Title: Reciprocal Degradation of YME1L and OMA1 Adapts Mitochondrial Proteolytic Activity during Stress.

The mitochondrial metalloprotease OMA1 was activated in a Bax- and Bak-dependent fashion.
Title: Activation of mitochondrial protease OMA1 by Bax and Bak promotes cytochrome c release during apoptosis.

These findings demonstrate that (a) p53 and Oma1 mediate L-Opa1 processing, (b) mitochondrial fragmentation is involved in CDDP-induced apoptosis in OVCA and CECA cells, and (c) dysregulated mitochondrial dynamics
Title: p53 is required for cisplatin-induced processing of the mitochondrial fusion protein L-Opa1 that is mediated by the mitochondrial metallopeptidase Oma1 in gynecologic cancers.

OMA1 is cleaved to a short form (S-OMA1) by itself upon mitochondrial membrane depolarization; S-OMA1 is degraded quickly but could be stabilized by CCCP treatment or Prohibitin knockdown in cells.
Title: Membrane depolarization activates the mitochondrial protease OMA1 by stimulating self-cleavage.

Cleavage of the inner membrane fusion factor L-OPA1 is prevented due to the failure to activate the inner membrane protease OMA1 in mitochondria that have a collapsed membrane potential.
Title: Impaired OMA1-dependent cleavage of OPA1 and reduced DRP1 fission activity combine to prevent mitophagy in cells that are dependent on oxidative phosphorylation.

The following OMA1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the OMA1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu74904	NM_145243.5 Latest version!	Homo sapiens OMA1 zinc metallopeptidase (OMA1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
View Old Accession Versions >>
OHu74904	NM_145243.4	Homo sapiens OMA1 zinc metallopeptidase (OMA1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

OMA1 ( NM_145243.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_660286.1 Homo sapiens OMA1 zinc metallopeptidase (OMA1), mRNA.

Price & Availability↑

CloneID	OHu74904
Clone ID Related Accession (Same CDS sequence)	NM_145243.5 , NM_145243.4
Accession Version	NM_145243.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1575bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-31
Organism	Homo sapiens(human)
Product	metalloendopeptidase OMA1, mitochondrial precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AL365187.19 and AL109845.8. On Nov 23, 2018 this sequence version replaced NM_145243.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC012915.1, AB048348.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000371226.8/ ENSP00000360270.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGAGCTTCA TCTGTGGATT GCAGTCTGCT GCTAGAAACC ATGTTTTCTT CCGATTTAAT 
TCACTGTCTA ACTGGAGAAA ATGTAACACA TTAGCATCCA CCTCACGGGG CTGTCATCAA 
GTACAAGTTA ACCATATAGT AAATAAGTAT CAGGGACTGG GAGTAAATCA GTGTGACAGG 
TGGAGTTTTC TGCCTGGAAA CTTTCATTTT TATAGTACTT TTAACAACAA AAGAACAGGA 
GGCCTCTCAA GTACCAAAAG TAAGGAAATT TGGAGGATTA CCAGCAAATG TACTGTATGG 
AATGATGCTT TTTCAAGACA GCTGCTAATA AAAGAAGTTA CAGCAGTCCC TAGTCTGTCA 
GTATTGCATC CTCTAAGCCC TGCTTCCATA AGAGCTATTA GGAATTTCCA TACTTCTCCA 
CGGTTTCAAG CTGCTCCGGT TCCTCTCTTG TTGATGATTC TTAAACCAGT ACAGAAGTTA 
TTTGCAATCA TTGTAGGCAG GGGCATAAGG AAATGGTGGC AGGCACTTCC TCCTAACAAG 
AAGGAAGTAG TTAAAGAAAA TATAAGGAAG AATAAATGGA AGCTATTCCT TGGTTTGAGT 
AGTTTTGGAT TGCTCTTTGT GGTGTTTTAT TTTACTCACC TGGAAGTAAG TCCAATCACA 
GGAAGGAGCA AGCTACTATT ATTGGGGAAA GAACAGTTCA GACTTTTATC GGAACTGGAA 
TATGAAGCAT GGATGGAAGA ATTTAAAAAT GATATGCTAA CTGAGAAAGA TGCCCGATAC 
CTGGCTGTTA AAGAAGTGCT TTGTCATCTA ATTGAATGCA ATAAAGATGT TCCAGGGATC 
TCTCAGATCA ATTGGGTTAT TCATGTGGTT GATTCCCCAA TTATTAATGC CTTCGTGCTT 
CCAAATGGAC AAATGTTTGT TTTCACTGGA TTTTTAAATA GTGTAACCGA TATTCATCAA 
CTTTCTTTCC TTCTGGGCCA TGAAATAGCA CATGCAGTAC TTGGGCATGC TGCAGAAAAG 
GCTGGCATGG TTCATTTGTT GGATTTCCTA GGTATGATTT TCCTCACAAT GATTTGGGCC 
ATTTGTCCTC GAGATAGCTT GGCACTTTTG TGCCAGTGGA TACAGTCTAA ATTGCAGGAG 
TATATGTTTA ATAGACCATA CAGCAGAAAA TTGGAGGCCG AAGCTGACAA AATTGGACTA 
CTGCTTGCTG CAAAGGCTTG TGCAGACATA AGAGCCAGTT CAGTGTTTTG GCAGCAAATG 
GAGTTCGTTG ATAGCCTGCA TGGCCAACCC AAGATGCCAG AATGGTTATC TACACACCCT 
TCTCATGGCA ATCGAGTTGA GTACTTGGAT AGACTTATAC CTCAGGCTCT CAAAATTAGA 
GAGATGTGTA ATTGTCCACC ACTGTCTAAT CCAGACCCTC GATTACTATT CAAACTCAGC 
ACGAAGCATT TTCTTGAAGA ATCAGAGAAA GAAGACCTAA ATATCACGAA GAAACAGAAA 
ATGGATACTC TTCCTATTCA AAAACAGGAG CAAATACCAT TAACATACAT AGTTGAGAAA 
AGAACGGGCA GTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_660286.1
CDS	41..1615
Translation	MSFICGLQSAARNHVFFRFNSLSNWRKCNTLASTSRGCHQVQVNHIVNKYQGLGVNQCDRWSFLPGNFHFYSTFNNKRTGGLSSTKSKEIWRITSKCTVWNDAFSRQLLIKEVTAVPSLSVLHPLSPASIRAIRNFHTSPRFQAAPVPLLLMILKPVQKLFAIIVGRGIRKWWQALPPNKKEVVKENIRKNKWKLFLGLSSFGLLFVVFYFTHLEVSPITGRSKLLLLGKEQFRLLSELEYEAWMEEFKNDMLTEKDARYLAVKEVLCHLIECNKDVPGISQINWVIHVVDSPIINAFVLPNGQMFVFTGFLNSVTDIHQLSFLLGHEIAHAVLGHAAEKAGMVHLLDFLGMIFLTMIWAICPRDSLALLCQWIQSKLQEYMFNRPYSRKLEAEADKIGLLLAAKACADIRASSVFWQQMEFVDSLHGQPKMPEWLSTHPSHGNRVEYLDRLIPQALKIREMCNCPPLSNPDPRLLFKLSTKHFLEESEKEDLNITKKQKMDTLPIQKQEQIPLTYIVEKRTGS

Target ORF information:

RefSeq Version	NM_145243.5
Organism	Homo sapiens(human)
Definition	Homo sapiens OMA1 zinc metallopeptidase (OMA1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_145243.5

ORF Insert Sequence:

ATGAGCTTCA TCTGTGGATT GCAGTCTGCT GCTAGAAACC ATGTTTTCTT CCGATTTAAT 
TCACTGTCTA ACTGGAGAAA ATGTAACACA TTAGCATCCA CCTCACGGGG CTGTCATCAA 
GTACAAGTTA ACCATATAGT AAATAAGTAT CAGGGACTGG GAGTAAATCA GTGTGACAGG 
TGGAGTTTTC TGCCTGGAAA CTTTCATTTT TATAGTACTT TTAACAACAA AAGAACAGGA 
GGCCTCTCAA GTACCAAAAG TAAGGAAATT TGGAGGATTA CCAGCAAATG TACTGTATGG 
AATGATGCTT TTTCAAGACA GCTGCTAATA AAAGAAGTTA CAGCAGTCCC TAGTCTGTCA 
GTATTGCATC CTCTAAGCCC TGCTTCCATA AGAGCTATTA GGAATTTCCA TACTTCTCCA 
CGGTTTCAAG CTGCTCCGGT TCCTCTCTTG TTGATGATTC TTAAACCAGT ACAGAAGTTA 
TTTGCAATCA TTGTAGGCAG GGGCATAAGG AAATGGTGGC AGGCACTTCC TCCTAACAAG 
AAGGAAGTAG TTAAAGAAAA TATAAGGAAG AATAAATGGA AGCTATTCCT TGGTTTGAGT 
AGTTTTGGAT TGCTCTTTGT GGTGTTTTAT TTTACTCACC TGGAAGTAAG TCCAATCACA 
GGAAGGAGCA AGCTACTATT ATTGGGGAAA GAACAGTTCA GACTTTTATC GGAACTGGAA 
TATGAAGCAT GGATGGAAGA ATTTAAAAAT GATATGCTAA CTGAGAAAGA TGCCCGATAC 
CTGGCTGTTA AAGAAGTGCT TTGTCATCTA ATTGAATGCA ATAAAGATGT TCCAGGGATC 
TCTCAGATCA ATTGGGTTAT TCATGTGGTT GATTCCCCAA TTATTAATGC CTTCGTGCTT 
CCAAATGGAC AAATGTTTGT TTTCACTGGA TTTTTAAATA GTGTAACCGA TATTCATCAA 
CTTTCTTTCC TTCTGGGCCA TGAAATAGCA CATGCAGTAC TTGGGCATGC TGCAGAAAAG 
GCTGGCATGG TTCATTTGTT GGATTTCCTA GGTATGATTT TCCTCACAAT GATTTGGGCC 
ATTTGTCCTC GAGATAGCTT GGCACTTTTG TGCCAGTGGA TACAGTCTAA ATTGCAGGAG 
TATATGTTTA ATAGACCATA CAGCAGAAAA TTGGAGGCCG AAGCTGACAA AATTGGACTA 
CTGCTTGCTG CAAAGGCTTG TGCAGACATA AGAGCCAGTT CAGTGTTTTG GCAGCAAATG 
GAGTTCGTTG ATAGCCTGCA TGGCCAACCC AAGATGCCAG AATGGTTATC TACACACCCT 
TCTCATGGCA ATCGAGTTGA GTACTTGGAT AGACTTATAC CTCAGGCTCT CAAAATTAGA 
GAGATGTGTA ATTGTCCACC ACTGTCTAAT CCAGACCCTC GATTACTATT CAAACTCAGC 
ACGAAGCATT TTCTTGAAGA ATCAGAGAAA GAAGACCTAA ATATCACGAA GAAACAGAAA 
ATGGATACTC TTCCTATTCA AAAACAGGAG CAAATACCAT TAACATACAT AGTTGAGAAA 
AGAACGGGCA GTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

OMA1 ( NM_145243.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_660286.1 Homo sapiens OMA1 zinc metallopeptidase (OMA1), mRNA.

Price & Availability↑

CloneID	OHu74904
Clone ID Related Accession (Same CDS sequence)	NM_145243.5 , NM_145243.4
Accession Version	NM_145243.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1575bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-02
Organism	Homo sapiens(human)
Product	metalloendopeptidase OMA1, mitochondrial precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BU191827.1, AB048348.1 and BC012915.1. On Dec 16, 2014 this sequence version replaced NM_145243.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC012915.1, SRR1660809.195346.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END##

ATGAGCTTCA TCTGTGGATT GCAGTCTGCT GCTAGAAACC ATGTTTTCTT CCGATTTAAT 
TCACTGTCTA ACTGGAGAAA ATGTAACACA TTAGCATCCA CCTCACGGGG CTGTCATCAA 
GTACAAGTTA ACCATATAGT AAATAAGTAT CAGGGACTGG GAGTAAATCA GTGTGACAGG 
TGGAGTTTTC TGCCTGGAAA CTTTCATTTT TATAGTACTT TTAACAACAA AAGAACAGGA 
GGCCTCTCAA GTACCAAAAG TAAGGAAATT TGGAGGATTA CCAGCAAATG TACTGTATGG 
AATGATGCTT TTTCAAGACA GCTGCTAATA AAAGAAGTTA CAGCAGTCCC TAGTCTGTCA 
GTATTGCATC CTCTAAGCCC TGCTTCCATA AGAGCTATTA GGAATTTCCA TACTTCTCCA 
CGGTTTCAAG CTGCTCCGGT TCCTCTCTTG TTGATGATTC TTAAACCAGT ACAGAAGTTA 
TTTGCAATCA TTGTAGGCAG GGGCATAAGG AAATGGTGGC AGGCACTTCC TCCTAACAAG 
AAGGAAGTAG TTAAAGAAAA TATAAGGAAG AATAAATGGA AGCTATTCCT TGGTTTGAGT 
AGTTTTGGAT TGCTCTTTGT GGTGTTTTAT TTTACTCACC TGGAAGTAAG TCCAATCACA 
GGAAGGAGCA AGCTACTATT ATTGGGGAAA GAACAGTTCA GACTTTTATC GGAACTGGAA 
TATGAAGCAT GGATGGAAGA ATTTAAAAAT GATATGCTAA CTGAGAAAGA TGCCCGATAC 
CTGGCTGTTA AAGAAGTGCT TTGTCATCTA ATTGAATGCA ATAAAGATGT TCCAGGGATC 
TCTCAGATCA ATTGGGTTAT TCATGTGGTT GATTCCCCAA TTATTAATGC CTTCGTGCTT 
CCAAATGGAC AAATGTTTGT TTTCACTGGA TTTTTAAATA GTGTAACCGA TATTCATCAA 
CTTTCTTTCC TTCTGGGCCA TGAAATAGCA CATGCAGTAC TTGGGCATGC TGCAGAAAAG 
GCTGGCATGG TTCATTTGTT GGATTTCCTA GGTATGATTT TCCTCACAAT GATTTGGGCC 
ATTTGTCCTC GAGATAGCTT GGCACTTTTG TGCCAGTGGA TACAGTCTAA ATTGCAGGAG 
TATATGTTTA ATAGACCATA CAGCAGAAAA TTGGAGGCCG AAGCTGACAA AATTGGACTA 
CTGCTTGCTG CAAAGGCTTG TGCAGACATA AGAGCCAGTT CAGTGTTTTG GCAGCAAATG 
GAGTTCGTTG ATAGCCTGCA TGGCCAACCC AAGATGCCAG AATGGTTATC TACACACCCT 
TCTCATGGCA ATCGAGTTGA GTACTTGGAT AGACTTATAC CTCAGGCTCT CAAAATTAGA 
GAGATGTGTA ATTGTCCACC ACTGTCTAAT CCAGACCCTC GATTACTATT CAAACTCAGC 
ACGAAGCATT TTCTTGAAGA ATCAGAGAAA GAAGACCTAA ATATCACGAA GAAACAGAAA 
ATGGATACTC TTCCTATTCA AAAACAGGAG CAAATACCAT TAACATACAT AGTTGAGAAA 
AGAACGGGCA GTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_660286.1
CDS	114..1688
Translation	MSFICGLQSAARNHVFFRFNSLSNWRKCNTLASTSRGCHQVQVNHIVNKYQGLGVNQCDRWSFLPGNFHFYSTFNNKRTGGLSSTKSKEIWRITSKCTVWNDAFSRQLLIKEVTAVPSLSVLHPLSPASIRAIRNFHTSPRFQAAPVPLLLMILKPVQKLFAIIVGRGIRKWWQALPPNKKEVVKENIRKNKWKLFLGLSSFGLLFVVFYFTHLEVSPITGRSKLLLLGKEQFRLLSELEYEAWMEEFKNDMLTEKDARYLAVKEVLCHLIECNKDVPGISQINWVIHVVDSPIINAFVLPNGQMFVFTGFLNSVTDIHQLSFLLGHEIAHAVLGHAAEKAGMVHLLDFLGMIFLTMIWAICPRDSLALLCQWIQSKLQEYMFNRPYSRKLEAEADKIGLLLAAKACADIRASSVFWQQMEFVDSLHGQPKMPEWLSTHPSHGNRVEYLDRLIPQALKIREMCNCPPLSNPDPRLLFKLSTKHFLEESEKEDLNITKKQKMDTLPIQKQEQIPLTYIVEKRTGS

Target ORF information:

RefSeq Version	NM_145243.4
Organism	Homo sapiens(human)
Definition	Homo sapiens OMA1 zinc metallopeptidase (OMA1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_145243.4

ORF Insert Sequence:

ATGAGCTTCA TCTGTGGATT GCAGTCTGCT GCTAGAAACC ATGTTTTCTT CCGATTTAAT 
TCACTGTCTA ACTGGAGAAA ATGTAACACA TTAGCATCCA CCTCACGGGG CTGTCATCAA 
GTACAAGTTA ACCATATAGT AAATAAGTAT CAGGGACTGG GAGTAAATCA GTGTGACAGG 
TGGAGTTTTC TGCCTGGAAA CTTTCATTTT TATAGTACTT TTAACAACAA AAGAACAGGA 
GGCCTCTCAA GTACCAAAAG TAAGGAAATT TGGAGGATTA CCAGCAAATG TACTGTATGG 
AATGATGCTT TTTCAAGACA GCTGCTAATA AAAGAAGTTA CAGCAGTCCC TAGTCTGTCA 
GTATTGCATC CTCTAAGCCC TGCTTCCATA AGAGCTATTA GGAATTTCCA TACTTCTCCA 
CGGTTTCAAG CTGCTCCGGT TCCTCTCTTG TTGATGATTC TTAAACCAGT ACAGAAGTTA 
TTTGCAATCA TTGTAGGCAG GGGCATAAGG AAATGGTGGC AGGCACTTCC TCCTAACAAG 
AAGGAAGTAG TTAAAGAAAA TATAAGGAAG AATAAATGGA AGCTATTCCT TGGTTTGAGT 
AGTTTTGGAT TGCTCTTTGT GGTGTTTTAT TTTACTCACC TGGAAGTAAG TCCAATCACA 
GGAAGGAGCA AGCTACTATT ATTGGGGAAA GAACAGTTCA GACTTTTATC GGAACTGGAA 
TATGAAGCAT GGATGGAAGA ATTTAAAAAT GATATGCTAA CTGAGAAAGA TGCCCGATAC 
CTGGCTGTTA AAGAAGTGCT TTGTCATCTA ATTGAATGCA ATAAAGATGT TCCAGGGATC 
TCTCAGATCA ATTGGGTTAT TCATGTGGTT GATTCCCCAA TTATTAATGC CTTCGTGCTT 
CCAAATGGAC AAATGTTTGT TTTCACTGGA TTTTTAAATA GTGTAACCGA TATTCATCAA 
CTTTCTTTCC TTCTGGGCCA TGAAATAGCA CATGCAGTAC TTGGGCATGC TGCAGAAAAG 
GCTGGCATGG TTCATTTGTT GGATTTCCTA GGTATGATTT TCCTCACAAT GATTTGGGCC 
ATTTGTCCTC GAGATAGCTT GGCACTTTTG TGCCAGTGGA TACAGTCTAA ATTGCAGGAG 
TATATGTTTA ATAGACCATA CAGCAGAAAA TTGGAGGCCG AAGCTGACAA AATTGGACTA 
CTGCTTGCTG CAAAGGCTTG TGCAGACATA AGAGCCAGTT CAGTGTTTTG GCAGCAAATG 
GAGTTCGTTG ATAGCCTGCA TGGCCAACCC AAGATGCCAG AATGGTTATC TACACACCCT 
TCTCATGGCA ATCGAGTTGA GTACTTGGAT AGACTTATAC CTCAGGCTCT CAAAATTAGA 
GAGATGTGTA ATTGTCCACC ACTGTCTAAT CCAGACCCTC GATTACTATT CAAACTCAGC 
ACGAAGCATT TTCTTGAAGA ATCAGAGAAA GAAGACCTAA ATATCACGAA GAAACAGAAA 
ATGGATACTC TTCCTATTCA AAAACAGGAG CAAATACCAT TAACATACAT AGTTGAGAAA 
AGAACGGGCA GTTGA