TUSC2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	TUSC2
Entrez Gene ID	11334
Full Name	tumor suppressor candidate 2
Synonyms	C3orf11,FUS1,PAP,PDAP2
General protein information	Preferred Names tumor suppressor candidate 2 Names tumor suppressor candidate 2 PDGFA-associated protein 2 fus-1 protein fusion 1 protein
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 3 Map Location: 3p21.31
Summary	This gene is a highly conserved lung cancer candidate gene. No other information about this gene is currently available. [provided by RefSeq, Jul 2008].
Disorder MIM:	607052

mRNA and Protein(s)

mRNA	Protein	Name
NM_007275.2	NP_009206.1	tumor suppressor candidate 2

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	TUSC2	XP_003309854.1
Mus musculus (house mouse)	Tusc2	NP_062716.1
Rattus norvegicus (Norway rat)	Tusc2	NP_001102767.1
	TUSC2	XP_001101682.1
Danio rerio (zebrafish)	tusc2b	NP_001002402.1
Danio rerio (zebrafish)	tusc2a	NP_001070767.1
Xenopus tropicalis (tropical clawed frog)	tusc2	XP_002935667.1
Homo sapiens (human)	TUSC2	NP_009206.1
Bos taurus (cattle)	TUSC2	XP_003587685.1
Gallus gallus (chicken)	TUSC2	XP_414259.2

Gene Ontology
Bibliography

Related articles in PubMed

TUSC2(FUS1)-erlotinib Induced Vulnerabilities in Epidermal Growth Factor Receptor(EGFR) Wildtype Non-small Cell Lung Cancer(NSCLC) Targeted by the Repurposed Drug Auranofin.
Xiaobo C, Majidi M, Feng M, Shao R, Wang J, Zhao Y, Baladandayuthapani V, Song J, Fang B, Ji L, Mehran R, Roth JA
Scientific reports635741(2016 Nov)

TWIST1/miR-584/TUSC2 pathway induces resistance to apoptosis in thyroid cancer cells.
Orlandella FM, Di Maro G, Ugolini C, Basolo F, Salvatore G
Oncotarget7(43)70575-70588(2016 Oct)

Uncovering Direct Targets of MiR-19a Involved in Lung Cancer Progression.
Yamamoto K, Ito S, Hanafusa H, Shimizu K, Ouchida M
PloS one10(9)e0137887(2015)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The therapeutic activity of TUSC2 could extend the use of erlotinib to lung cancer patients with wildtype EGFR.
Title: Exogenous Restoration of TUSC2 Expression Induces Responsiveness to Erlotinib in Wildtype Epidermal Growth Factor Receptor (EGFR) Lung Cancer Cells through Context Specific Pathways Resulting in Enhanced Therapeutic Efficacy.

FOXP1, TP53INP1, TNFAIP3, and TUSC2 were identified as miR-19a targets.
Title: Uncovering Direct Targets of MiR-19a Involved in Lung Cancer Progression.

TUSC2P and TUSC2 3'-UTR expression inhibits cell proliferation, survival, migration, invasion and colony formation, and increases tumor cell death. TUSC2P and TUSC2 3'-UTR bind to miRNAs and arrest their functions, leading to increased TUSC2 translation.
Title: The pseudogene TUSC2P promotes TUSC2 function by binding multiple microRNAs.

The tumor suppressor gene TUSC2 (FUS1) sensitizes NSCLC to the AKT inhibitor MK2206 in LKB1-dependent manner.
Title: The tumor suppressor gene TUSC2 (FUS1) sensitizes NSCLC to the AKT inhibitor MK2206 in LKB1-dependent manner.

RNA sequence elements in FUS1 UTRs that regulate FUS1 protein express were identified.
Title: Regulation of tumor suppressor gene FUS1 expression by the untranslated regions of mRNA in human lung cancer cells.

The following TUSC2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the TUSC2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu29763	NM_007275.2 Latest version!	Homo sapiens tumor suppressor 2, mitochondrial calcium regulator (TUSC2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

TUSC2 ( NM_007275.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_009206.1 Homo sapiens tumor suppressor 2, mitochondrial calcium regulator (TUSC2), mRNA.

Price & Availability↑

CloneID	OHu29763
Clone ID Related Accession (Same CDS sequence)	NM_007275.2
Accession Version	NM_007275.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 333bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-26
Organism	Homo sapiens(human)
Product	tumor suppressor candidate 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CA392689.1 and BC023976.2. On Jul 26, 2014 this sequence version replaced NM_007275.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163658.125991.1, AF055479.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2150385, SAMEA2467148 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology RefSeq Select criteria :: based on single protein-coding transcript regulatory uORF :: PMID: 21645495 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGGCGCCA GCGGGTCCAA AGCTCGGGGC CTGTGGCCCT TCGCCTCGGC GGCCGGAGGC 
GGCGGCTCAG AGGCAGCAGG AGCTGAGCAA GCTTTGGTGC GGCCTCGGGG CCGAGCTGTG 
CCCCCCTTCG TATTCACGCG CCGCGGCTCT ATGTTCTATG ATGAGGATGG GGATCTGGCT 
CACGAGTTCT ATGAGGAGAC AATCGTCACC AAGAACGGGC AGAAGCGGGC CAAGCTGAGG 
CGAGTGCATA AGAATCTGAT TCCTCAGGGC ATCGTGAAGC TGGATCACCC CCGCATCCAC 
GTGGATTTCC CTGTGATCCT CTATGAGGTG TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_009206.1
CDS	140..472
Translation	MGASGSKARGLWPFASAAGGGGSEAAGAEQALVRPRGRAVPPFVFTRRGSMFYDEDGDLAHEFYEETIVTKNGQKRAKLRRVHKNLIPQGIVKLDHPRIHVDFPVILYEV

Target ORF information:

RefSeq Version	NM_007275.2
Organism	Homo sapiens(human)
Definition	Homo sapiens tumor suppressor 2, mitochondrial calcium regulator (TUSC2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_007275.2

ORF Insert Sequence:

ATGGGCGCCA GCGGGTCCAA AGCTCGGGGC CTGTGGCCCT TCGCCTCGGC GGCCGGAGGC 
GGCGGCTCAG AGGCAGCAGG AGCTGAGCAA GCTTTGGTGC GGCCTCGGGG CCGAGCTGTG 
CCCCCCTTCG TATTCACGCG CCGCGGCTCT ATGTTCTATG ATGAGGATGG GGATCTGGCT 
CACGAGTTCT ATGAGGAGAC AATCGTCACC AAGAACGGGC AGAAGCGGGC CAAGCTGAGG 
CGAGTGCATA AGAATCTGAT TCCTCAGGGC ATCGTGAAGC TGGATCACCC CCGCATCCAC 
GTGGATTTCC CTGTGATCCT CTATGAGGTG TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

TUSC2(FUS1)-erlotinib Induced Vulnerabilities in Epidermal Growth Factor Receptor(EGFR) Wildtype Non-small Cell Lung Cancer(NSCLC) Targeted by the Repurposed Drug Auranofin.
Scientific reports635741(2016 Nov)
Xiaobo C,Majidi M,Feng M,Shao R,Wang J,Zhao Y,Baladandayuthapani V,Song J,Fang B,Ji L,Mehran R,Roth JA

TWIST1/miR-584/TUSC2 pathway induces resistance to apoptosis in thyroid cancer cells.
Oncotarget7(43)70575-70588(2016 Oct)
Orlandella FM,Di Maro G,Ugolini C,Basolo F,Salvatore G

Uncovering Direct Targets of MiR-19a Involved in Lung Cancer Progression.
PloS one10(9)e0137887(2015)
Yamamoto K,Ito S,Hanafusa H,Shimizu K,Ouchida M