PTH2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	PTH2
Entrez Gene ID	113091
Full Name	parathyroid hormone 2
Synonyms	TIP39
General protein information	Preferred Names parathyroid hormone 2 Names tuberoinfundibular peptide of 39 residues tuberoinfundibular 39 residue protein
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 19 Map Location: 19q13.33
Summary	This gene encodes the precursor of a peptide hormone that shares sequence similarity with the parathyroid hormone. This gene is expressed in various regions of the brain where it plays a role in the release of pituitary hormones, anxiety and nociception. The encoded precursor protein is proteolytically processed to generate the biologically active neuropeptide. [provided by RefSeq, Jul 2015].
Disorder MIM:	608386

mRNA and Protein(s)

mRNA	Protein	Name
NM_178449.3	NP_848544.1	tuberoinfundibular peptide of 39 residues preproprotein
NM_178449.4	NP_848544.1	tuberoinfundibular peptide of 39 residues preproprotein

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	PTH2	XP_003638907.1
Bos taurus (cattle)	PTH2	NP_001193210.1
Homo sapiens (human)	PTH2	NP_848544.1
Rattus norvegicus (Norway rat)	Pth2	NP_001102614.1
	PTH2	XP_001114966.1
Mus musculus (house mouse)	Pth2	NP_444486.1

Gene Ontology
Bibliography

Related articles in PubMed

The parathyroid hormone family member TIP39 interacts with sarco/endoplasmic reticulum Ca
Sato E, Williams MR, Sanford JA, Sen GL, Nakama T, Imafuku S, Gallo RL
Experimental dermatology26(9)792-797(2017 Sep)

Bit1-a potential positive regulator of epithelial-mesenchymal transition in lens epithelial cells.
Wu X, Ruan J, Ma B, Luo M
Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie254(7)1311-8(2016 Jul)

Parathyroid hormone 2 receptor and its endogenous ligand tuberoinfundibular peptide of 39 residues are concentrated in endocrine, viscerosensory and auditory brain regions in macaque and human.
Bag? AG, Dimitrov E, Saunders R, Seress L, Palkovits M, Usdin TB, Dobolyi A
Neuroscience162(1)128-47(2009 Aug)

Reviews in molecular biology and biotechnology: transmembrane signaling by G protein-coupled receptors.
Luttrell LM
Molecular biotechnology39(3)239-64(2008 Jul)

Agonist-specific regulation of parathyroid hormone (PTH) receptor type 2 activity: structural and functional analysis of PTH- and tuberoinfundibular peptide (TIP) 39-stimulated desensitization and internalization.
Bisello A, Manen D, Pierroz DD, Usdin TB, Rizzoli R, Ferrari SL
Molecular endocrinology (Baltimore, Md.)18(6)1486-98(2004 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Bit1 promotes TGF-beta2 induced alpha-SMA expression and acts as an positive regulator of EMT.
Title: Bit1-a potential positive regulator of epithelial-mesenchymal transition in lens epithelial cells.

The results demonstrate that TIP39 and the PTH2R are expressed in the brain of primates in locations that suggest involvement in regulation of fear, anxiety, reproductive behaviors, release of pituitary hormones, and nociception.
Title: Parathyroid hormone 2 receptor and its endogenous ligand tuberoinfundibular peptide of 39 residues are concentrated in endocrine, viscerosensory and auditory brain regions in macaque and human.

The following PTH2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PTH2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu30716	NM_178449.4 Latest version!	Homo sapiens parathyroid hormone 2 (PTH2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu30716	NM_178449.3	Homo sapiens parathyroid hormone 2 (PTH2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

PTH2 ( NM_178449.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_848544.1 Homo sapiens parathyroid hormone 2 (PTH2), mRNA.

Price & Availability↑

CloneID	OHu30716
Clone ID Related Accession (Same CDS sequence)	NM_178449.3 , NM_178449.4
Accession Version	NM_178449.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 303bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-09-16
Organism	Homo sapiens(human)
Product	tuberoinfundibular peptide of 39 residues preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AY037555.1 and BC093997.1. On Sep 26, 2008 this sequence version replaced NM_178449.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AY037555.1, BC093997.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN02400289 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## CDS uses downstream in-frame AUG :: downstream AUG is associated with N-terminal localization signal (PMID:12098667) ##RefSeq-Attributes-END##

ATGGAGACCC GCCAGGTGTC CAGGAGCCCT CGGGTTCGGC TGCTGCTGCT GCTGCTGCTG 
CTGCTGGTGG TGCCCTGGGG CGTCCGCACT GCCTCGGGAG TCGCCCTGCC CCCGGTCGGG 
GTCCTCAGCC TCCGCCCCCC AGGACGGGCC TGGGCGGATC CCGCCACCCC CAGGCCGCGG 
AGGAGCCTGG CGCTGGCGGA CGACGCGGCC TTCCGGGAGC GCGCGCGGTT GCTGGCCGCC 
CTCGAGCGCC GCCACTGGCT GAACTCGTAC ATGCACAAGC TGCTGGTGTT GGATGCGCCC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_848544.1
CDS	103..405
Translation	METRQVSRSPRVRLLLLLLLLLVVPWGVRTASGVALPPVGVLSLRPPGRAWADPATPRPRRSLALADDAAFRERARLLAALERRHWLNSYMHKLLVLDAP

Target ORF information:

RefSeq Version	NM_178449.3
Organism	Homo sapiens(human)
Definition	Homo sapiens parathyroid hormone 2 (PTH2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_178449.3

ORF Insert Sequence:

ATGGAGACCC GCCAGGTGTC CAGGAGCCCT CGGGTTCGGC TGCTGCTGCT GCTGCTGCTG 
CTGCTGGTGG TGCCCTGGGG CGTCCGCACT GCCTCGGGAG TCGCCCTGCC CCCGGTCGGG 
GTCCTCAGCC TCCGCCCCCC AGGACGGGCC TGGGCGGATC CCGCCACCCC CAGGCCGCGG 
AGGAGCCTGG CGCTGGCGGA CGACGCGGCC TTCCGGGAGC GCGCGCGGTT GCTGGCCGCC 
CTCGAGCGCC GCCACTGGCT GAACTCGTAC ATGCACAAGC TGCTGGTGTT GGATGCGCCC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PTH2 ( NM_178449.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_848544.1 Homo sapiens parathyroid hormone 2 (PTH2), mRNA.

Price & Availability↑

CloneID	OHu30716
Clone ID Related Accession (Same CDS sequence)	NM_178449.3 , NM_178449.4
Accession Version	NM_178449.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 303bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-25
Organism	Homo sapiens(human)
Product	tuberoinfundibular peptide of 39 residues preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AY037555.1 and BC093997.1. On May 17, 2019 this sequence version replaced NM_178449.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AY037555.1, BC093997.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN02400289 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## CDS uses downstream in-frame AUG :: downstream AUG is associated with N-terminal localization signal (PMID:12098667) MANE Ensembl match :: ENST00000270631.2/ ENSP00000270631.1 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##

ATGGAGACCC GCCAGGTGTC CAGGAGCCCT CGGGTTCGGC TGCTGCTGCT GCTGCTGCTG 
CTGCTGGTGG TGCCCTGGGG CGTCCGCACT GCCTCGGGAG TCGCCCTGCC CCCGGTCGGG 
GTCCTCAGCC TCCGCCCCCC AGGACGGGCC TGGGCGGATC CCGCCACCCC CAGGCCGCGG 
AGGAGCCTGG CGCTGGCGGA CGACGCGGCC TTCCGGGAGC GCGCGCGGTT GCTGGCCGCC 
CTCGAGCGCC GCCACTGGCT GAACTCGTAC ATGCACAAGC TGCTGGTGTT GGATGCGCCC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_848544.1
CDS	103..405
Translation	METRQVSRSPRVRLLLLLLLLLVVPWGVRTASGVALPPVGVLSLRPPGRAWADPATPRPRRSLALADDAAFRERARLLAALERRHWLNSYMHKLLVLDAP

Target ORF information:

RefSeq Version	NM_178449.4
Organism	Homo sapiens(human)
Definition	Homo sapiens parathyroid hormone 2 (PTH2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_178449.4

ORF Insert Sequence:

ATGGAGACCC GCCAGGTGTC CAGGAGCCCT CGGGTTCGGC TGCTGCTGCT GCTGCTGCTG 
CTGCTGGTGG TGCCCTGGGG CGTCCGCACT GCCTCGGGAG TCGCCCTGCC CCCGGTCGGG 
GTCCTCAGCC TCCGCCCCCC AGGACGGGCC TGGGCGGATC CCGCCACCCC CAGGCCGCGG 
AGGAGCCTGG CGCTGGCGGA CGACGCGGCC TTCCGGGAGC GCGCGCGGTT GCTGGCCGCC 
CTCGAGCGCC GCCACTGGCT GAACTCGTAC ATGCACAAGC TGCTGGTGTT GGATGCGCCC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The parathyroid hormone family member TIP39 interacts with sarco/endoplasmic reticulum Ca
Experimental dermatology26(9)792-797(2017 Sep)
Sato E,Williams MR,Sanford JA,Sen GL,Nakama T,Imafuku S,Gallo RL

Bit1-a potential positive regulator of epithelial-mesenchymal transition in lens epithelial cells.
Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie254(7)1311-8(2016 Jul)
Wu X,Ruan J,Ma B,Luo M

Parathyroid hormone 2 receptor and its endogenous ligand tuberoinfundibular peptide of 39 residues are concentrated in endocrine, viscerosensory and auditory brain regions in macaque and human.
Neuroscience162(1)128-47(2009 Aug)
Bag? AG,Dimitrov E,Saunders R,Seress L,Palkovits M,Usdin TB,Dobolyi A

Reviews in molecular biology and biotechnology: transmembrane signaling by G protein-coupled receptors.
Molecular biotechnology39(3)239-64(2008 Jul)
Luttrell LM

Agonist-specific regulation of parathyroid hormone (PTH) receptor type 2 activity: structural and functional analysis of PTH- and tuberoinfundibular peptide (TIP) 39-stimulated desensitization and internalization.
Molecular endocrinology (Baltimore, Md.)18(6)1486-98(2004 Jun)
Bisello A,Manen D,Pierroz DD,Usdin TB,Rizzoli R,Ferrari SL