KRT71 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	KRT71
Entrez Gene ID	112802
Full Name	keratin 71
Synonyms	HYPT13,K6IRS1,KRT6IRS,KRT6IRS1
General protein information	Preferred Names keratin 71 Names keratin, type II cytoskeletal 71 CK-71 K71 cytokeratin-71 hK6irs hK6irs1 keratin 6 irs keratin 71, type II type II inner root sheath-specific keratin-K6irs1 type-II keratin Kb34
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 12 Map Location: 12q13.13
Summary	Keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into epithelial keratins and hair keratins. This gene encodes a protein that is expressed in the inner root sheath of hair follicles. The type II keratins are clustered in a region of chromosome 12q13.[provided by RefSeq, Jun 2009].
Disorder MIM:	608245
Disorder Html:	?Hypotrichosis 13, 615896 (3)

mRNA and Protein(s)

mRNA	Protein	Name
XM_017018749.1	XP_016874238.1	keratin, type II cytoskeletal 71 isoform X1
NM_033448.2	NP_258259.1	keratin, type II cytoskeletal 71
NM_033448.3	NP_258259.1	keratin, type II cytoskeletal 71

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	KRT71	NP_001183958.1
Pan troglodytes (chimpanzee)	KRT71	XP_003313729.1
Gallus gallus (chicken)	KRT75L2	XP_428850.2
Homo sapiens (human)	KRT71	NP_258259.1
	LOC698941	XP_001097289.1
Bos taurus (cattle)	KRT71	NP_001069438.1
Mus musculus (house mouse)	Krt71	NP_064340.1
Rattus norvegicus (Norway rat)	Krt71	NP_001263369.1
Gallus gallus (chicken)	LOC768881	XP_001232027.2

Gene Ontology
Bibliography

Related articles in PubMed

A missense mutation within the helix initiation motif of the keratin K71 gene underlies autosomal dominant woolly hair/hypotrichosis.
Fujimoto A, Farooq M, Fujikawa H, Inoue A, Ohyama M, Ehama R, Nakanishi J, Hagihara M, Iwabuchi T, Aoki J, Ito M, Shimomura Y
The Journal of investigative dermatology132(10)2342-2349(2012 Oct)

New consensus nomenclature for mammalian keratins.
Schweizer J, Bowden PE, Coulombe PA, Langbein L, Lane EB, Magin TM, Maltais L, Omary MB, Parry DA, Rogers MA, Wright MW
The Journal of cell biology174(2)169-74(2006 Jul)

K6irs1, K6irs2, K6irs3, and K6irs4 represent the inner-root-sheath-specific type II epithelial keratins of the human hair follicle.
Langbein L, Rogers MA, Praetzel S, Winter H, Schweizer J
The Journal of investigative dermatology120(4)512-22(2003 Apr)

A novel epithelial keratin, hK6irs1, is expressed differentially in all layers of the inner root sheath, including specialized huxley cells (Fl?gelzellen) of the human hair follicle.
Langbein L, Rogers MA, Praetzel S, Aoki N, Winter H, Schweizer J
The Journal of investigative dermatology118(5)789-99(2002 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Demonstration of the heterozygous mutation c.422T>G (p.Phe141Cys) within the helix initiation motif of the inner root sheath-specific keratin K71 (KRT71) gene in affected family members with autosomal dominant woolly hair/hypotrichosis.
Title: A missense mutation within the helix initiation motif of the keratin K71 gene underlies autosomal dominant woolly hair/hypotrichosis.

A novel epithelial keratin, hK6irs1, is expressed differentially in all layers of the inner root sheath, including specialized huxley cells (Flugelzellen) of the human hair follicle.(HK6IRS1)
Title: A novel epithelial keratin, hK6irs1, is expressed differentially in all layers of the inner root sheath, including specialized huxley cells (Fl?gelzellen) of the human hair follicle.

The following KRT71 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the KRT71 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu18875	NM_033448.3 Latest version!	Homo sapiens keratin 71 (KRT71), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00
OHu83485	XM_017018749.1 Latest version!	Homo sapiens keratin 71 (KRT71), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00
View Old Accession Versions >>
OHu18875	NM_033448.2	Homo sapiens keratin 71 (KRT71), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

KRT71 ( NM_033448.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_258259.1 Homo sapiens keratin 71 (KRT71), mRNA.

Price & Availability↑

CloneID	OHu18875
Clone ID Related Accession (Same CDS sequence)	NM_033448.2 , NM_033448.3
Accession Version	NM_033448.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1572bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-06-23
Organism	Homo sapiens(human)
Product	keratin, type II cytoskeletal 71
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK122795.1 and AJ308599.1. This sequence is a reference standard in the RefSeqGene project. On Apr 2, 2009 this sequence version replaced NM_033448.1. ##Evidence-Data-START## Transcript exon combination :: AK122795.1, BC103917.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1968968, SAMEA2144333 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAGCCGCC AATTCACCTG CAAGTCGGGA GCTGCCGCCA AGGGGGGCTT CAGTGGCTGC 
TCAGCTGTGC TCTCAGGGGG CAGCTCATCC TCCTTCCGGG CAGGGAGCAA AGGGCTCAGT 
GGGGGCTTTG GCAGCCGGAG CCTCTACAGC CTGGGGGGTG TCCGGAGCCT CAATGTGGCC 
AGTGGCAGCG GGAAGAGTGG AGGCTATGGA TTTGGCCGGG GCCGGGCCAG TGGCTTTGCT 
GGAAGCATGT TTGGCAGTGT GGCCCTGGGG CCTGTGTGCC CAACTGTATG CCCACCTGGA 
GGCATCCACC AGGTTACCGT CAATGAGAGC CTCCTGGCCC CCCTCAACGT GGAGCTGGAC 
CCCGAGATCC AGAAAGTGCG TGCCCAGGAG CGAGAGCAGA TCAAGGCTCT GAACAACAAG 
TTCGCCTCCT TCATCGACAA GGTGCGGTTC CTGGAGCAGC AGAACCAGGT ACTGGAGACC 
AAGTGGGAGC TGCTGCAGCA GCTGGACCTG AACAACTGCA AGAACAACCT GGAGCCCATC 
CTCGAGGGCT ACATCAGCAA CCTGCGGAAG CAGCTGGAGA CGCTGTCTGG GGACAGGGTG 
AGGCTGGACT CGGAGCTGAG GAATGTGCGG GACGTAGTGG AGGACTACAA GAAGAGGTAT 
GAGGAGGAAA TCAACAAGCG GACAGCAGCA GAGAACGAGT TTGTGCTGCT CAAGAAGGAT 
GTGGATGCTG CTTACGCCAA TAAGGTGGAA CTGCAGGCCA AGGTGGAATC CATGGACCAG 
GAGATCAAGT TCTTCAGGTG TCTCTTTGAA GCCGAGATCA CTCAGATCCA GTCCCACATC 
AGTGACATGT CTGTCATCCT GTCCATGGAC AACAACCGGA ACCTAGACCT GGACAGCATC 
ATTGACGAAG TCCGCACCCA GTATGAGGAG ATTGCCTTGA AGAGTAAGGC CGAGGCTGAG 
GCCCTGTACC AGACCAAGTT CCAAGAGCTT CAGCTGGCAG CTGGCAGGCA TGGGGACGAC 
CTCAAAAACA CCAAGAATGA AATCTCGGAG CTCACTCGGC TCATCCAGAG AATCCGCTCA 
GAGATCGAGA ACGTGAAGAA GCAGGCTTCC AACCTGGAGA CAGCCATCGC TGATGCTGAG 
CAGCGGGGAG ACAACGCCCT GAAGGATGCC CGGGCCAAGC TGGACGAGCT GGAGGGCGCC 
CTGCACCAGG CCAAGGAGGA GCTGGCGCGG ATGCTGCGCG AGTACCAGGA GCTCATGAGC 
CTGAAGCTGG CCCTGGACAT GGAGATCGCC ACCTATCGCA AGCTACTGGA GAGCGAGGAG 
TGCAGGATGT CAGGAGAATT TCCCTCCCCT GTCAGCATCT CCATCATCAG CAGCACCAGT 
GGCGGCAGTG TCTATGGCTT CCGGCCCAGC ATGGTCAGCG GTGGCTATGT GGCCAACAGC 
AGCAACTGCA TCTCTGGAGT GTGCAGCGTG AGAGGCGGGG AGGGCAGGAG CCGGGGCAGT 
GCCAACGATT ACAAAGACAC CCTAGGGAAG GGTTCCAGCC TGAGTGCACC CTCCAAGAAA 
ACCAGTCGGT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_258259.1
CDS	71..1642
Translation	MSRQFTCKSGAAAKGGFSGCSAVLSGGSSSSFRAGSKGLSGGFGSRSLYSLGGVRSLNVASGSGKSGGYGFGRGRASGFAGSMFGSVALGPVCPTVCPPGGIHQVTVNESLLAPLNVELDPEIQKVRAQEREQIKALNNKFASFIDKVRFLEQQNQVLETKWELLQQLDLNNCKNNLEPILEGYISNLRKQLETLSGDRVRLDSELRNVRDVVEDYKKRYEEEINKRTAAENEFVLLKKDVDAAYANKVELQAKVESMDQEIKFFRCLFEAEITQIQSHISDMSVILSMDNNRNLDLDSIIDEVRTQYEEIALKSKAEAEALYQTKFQELQLAAGRHGDDLKNTKNEISELTRLIQRIRSEIENVKKQASNLETAIADAEQRGDNALKDARAKLDELEGALHQAKEELARMLREYQELMSLKLALDMEIATYRKLLESEECRMSGEFPSPVSISIISSTSGGSVYGFRPSMVSGGYVANSSNCISGVCSVRGGEGRSRGSANDYKDTLGKGSSLSAPSKKTSR

Target ORF information:

RefSeq Version	NM_033448.2
Organism	Homo sapiens(human)
Definition	Homo sapiens keratin 71 (KRT71), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_033448.2

ORF Insert Sequence:

ATGAGCCGCC AATTCACCTG CAAGTCGGGA GCTGCCGCCA AGGGGGGCTT CAGTGGCTGC 
TCAGCTGTGC TCTCAGGGGG CAGCTCATCC TCCTTCCGGG CAGGGAGCAA AGGGCTCAGT 
GGGGGCTTTG GCAGCCGGAG CCTCTACAGC CTGGGGGGTG TCCGGAGCCT CAATGTGGCC 
AGTGGCAGCG GGAAGAGTGG AGGCTATGGA TTTGGCCGGG GCCGGGCCAG TGGCTTTGCT 
GGAAGCATGT TTGGCAGTGT GGCCCTGGGG CCTGTGTGCC CAACTGTATG CCCACCTGGA 
GGCATCCACC AGGTTACCGT CAATGAGAGC CTCCTGGCCC CCCTCAACGT GGAGCTGGAC 
CCCGAGATCC AGAAAGTGCG TGCCCAGGAG CGAGAGCAGA TCAAGGCTCT GAACAACAAG 
TTCGCCTCCT TCATCGACAA GGTGCGGTTC CTGGAGCAGC AGAACCAGGT ACTGGAGACC 
AAGTGGGAGC TGCTGCAGCA GCTGGACCTG AACAACTGCA AGAACAACCT GGAGCCCATC 
CTCGAGGGCT ACATCAGCAA CCTGCGGAAG CAGCTGGAGA CGCTGTCTGG GGACAGGGTG 
AGGCTGGACT CGGAGCTGAG GAATGTGCGG GACGTAGTGG AGGACTACAA GAAGAGGTAT 
GAGGAGGAAA TCAACAAGCG GACAGCAGCA GAGAACGAGT TTGTGCTGCT CAAGAAGGAT 
GTGGATGCTG CTTACGCCAA TAAGGTGGAA CTGCAGGCCA AGGTGGAATC CATGGACCAG 
GAGATCAAGT TCTTCAGGTG TCTCTTTGAA GCCGAGATCA CTCAGATCCA GTCCCACATC 
AGTGACATGT CTGTCATCCT GTCCATGGAC AACAACCGGA ACCTAGACCT GGACAGCATC 
ATTGACGAAG TCCGCACCCA GTATGAGGAG ATTGCCTTGA AGAGTAAGGC CGAGGCTGAG 
GCCCTGTACC AGACCAAGTT CCAAGAGCTT CAGCTGGCAG CTGGCAGGCA TGGGGACGAC 
CTCAAAAACA CCAAGAATGA AATCTCGGAG CTCACTCGGC TCATCCAGAG AATCCGCTCA 
GAGATCGAGA ACGTGAAGAA GCAGGCTTCC AACCTGGAGA CAGCCATCGC TGATGCTGAG 
CAGCGGGGAG ACAACGCCCT GAAGGATGCC CGGGCCAAGC TGGACGAGCT GGAGGGCGCC 
CTGCACCAGG CCAAGGAGGA GCTGGCGCGG ATGCTGCGCG AGTACCAGGA GCTCATGAGC 
CTGAAGCTGG CCCTGGACAT GGAGATCGCC ACCTATCGCA AGCTACTGGA GAGCGAGGAG 
TGCAGGATGT CAGGAGAATT TCCCTCCCCT GTCAGCATCT CCATCATCAG CAGCACCAGT 
GGCGGCAGTG TCTATGGCTT CCGGCCCAGC ATGGTCAGCG GTGGCTATGT GGCCAACAGC 
AGCAACTGCA TCTCTGGAGT GTGCAGCGTG AGAGGCGGGG AGGGCAGGAG CCGGGGCAGT 
GCCAACGATT ACAAAGACAC CCTAGGGAAG GGTTCCAGCC TGAGTGCACC CTCCAAGAAA 
ACCAGTCGGT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

KRT71 ( NM_033448.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_258259.1 Homo sapiens keratin 71 (KRT71), mRNA.

Price & Availability↑

CloneID	OHu18875
Clone ID Related Accession (Same CDS sequence)	NM_033448.2 , NM_033448.3
Accession Version	NM_033448.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1572bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-25
Organism	Homo sapiens(human)
Product	keratin, type II cytoskeletal 71
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK122795.1 and AJ308599.1. This sequence is a reference standard in the RefSeqGene project. On May 17, 2019 this sequence version replaced NM_033448.2. ##Evidence-Data-START## Transcript exon combination :: AJ308599.1, AK122795.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1968968, SAMEA2144333 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000267119.6/ ENSP00000267119.5 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGAGCCGCC AATTCACCTG CAAGTCGGGA GCTGCCGCCA AGGGGGGCTT CAGTGGCTGC 
TCAGCTGTGC TCTCAGGGGG CAGCTCATCC TCCTTCCGGG CAGGGAGCAA AGGGCTCAGT 
GGGGGCTTTG GCAGCCGGAG CCTCTACAGC CTGGGGGGTG TCCGGAGCCT CAATGTGGCC 
AGTGGCAGCG GGAAGAGTGG AGGCTATGGA TTTGGCCGGG GCCGGGCCAG TGGCTTTGCT 
GGAAGCATGT TTGGCAGTGT GGCCCTGGGG CCTGTGTGCC CAACTGTATG CCCACCTGGA 
GGCATCCACC AGGTTACCGT CAATGAGAGC CTCCTGGCCC CCCTCAACGT GGAGCTGGAC 
CCCGAGATCC AGAAAGTGCG TGCCCAGGAG CGAGAGCAGA TCAAGGCTCT GAACAACAAG 
TTCGCCTCCT TCATCGACAA GGTGCGGTTC CTGGAGCAGC AGAACCAGGT ACTGGAGACC 
AAGTGGGAGC TGCTGCAGCA GCTGGACCTG AACAACTGCA AGAACAACCT GGAGCCCATC 
CTCGAGGGCT ACATCAGCAA CCTGCGGAAG CAGCTGGAGA CGCTGTCTGG GGACAGGGTG 
AGGCTGGACT CGGAGCTGAG GAATGTGCGG GACGTAGTGG AGGACTACAA GAAGAGGTAT 
GAGGAGGAAA TCAACAAGCG GACAGCAGCA GAGAACGAGT TTGTGCTGCT CAAGAAGGAT 
GTGGATGCTG CTTACGCCAA TAAGGTGGAA CTGCAGGCCA AGGTGGAATC CATGGACCAG 
GAGATCAAGT TCTTCAGGTG TCTCTTTGAA GCCGAGATCA CTCAGATCCA GTCCCACATC 
AGTGACATGT CTGTCATCCT GTCCATGGAC AACAACCGGA ACCTAGACCT GGACAGCATC 
ATTGACGAAG TCCGCACCCA GTATGAGGAG ATTGCCTTGA AGAGTAAGGC CGAGGCTGAG 
GCCCTGTACC AGACCAAGTT CCAAGAGCTT CAGCTGGCAG CTGGCAGGCA TGGGGACGAC 
CTCAAAAACA CCAAGAATGA AATCTCGGAG CTCACTCGGC TCATCCAGAG AATCCGCTCA 
GAGATCGAGA ACGTGAAGAA GCAGGCTTCC AACCTGGAGA CAGCCATCGC TGATGCTGAG 
CAGCGGGGAG ACAACGCCCT GAAGGATGCC CGGGCCAAGC TGGACGAGCT GGAGGGCGCC 
CTGCACCAGG CCAAGGAGGA GCTGGCGCGG ATGCTGCGCG AGTACCAGGA GCTCATGAGC 
CTGAAGCTGG CCCTGGACAT GGAGATCGCC ACCTATCGCA AGCTACTGGA GAGCGAGGAG 
TGCAGGATGT CAGGAGAATT TCCCTCCCCT GTCAGCATCT CCATCATCAG CAGCACCAGT 
GGCGGCAGTG TCTATGGCTT CCGGCCCAGC ATGGTCAGCG GTGGCTATGT GGCCAACAGC 
AGCAACTGCA TCTCTGGAGT GTGCAGCGTG AGAGGCGGGG AGGGCAGGAG CCGGGGCAGT 
GCCAACGATT ACAAAGACAC CCTAGGGAAG GGTTCCAGCC TGAGTGCACC CTCCAAGAAA 
ACCAGTCGGT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_258259.1
CDS	69..1640
Translation	MSRQFTCKSGAAAKGGFSGCSAVLSGGSSSSFRAGSKGLSGGFGSRSLYSLGGVRSLNVASGSGKSGGYGFGRGRASGFAGSMFGSVALGPVCPTVCPPGGIHQVTVNESLLAPLNVELDPEIQKVRAQEREQIKALNNKFASFIDKVRFLEQQNQVLETKWELLQQLDLNNCKNNLEPILEGYISNLRKQLETLSGDRVRLDSELRNVRDVVEDYKKRYEEEINKRTAAENEFVLLKKDVDAAYANKVELQAKVESMDQEIKFFRCLFEAEITQIQSHISDMSVILSMDNNRNLDLDSIIDEVRTQYEEIALKSKAEAEALYQTKFQELQLAAGRHGDDLKNTKNEISELTRLIQRIRSEIENVKKQASNLETAIADAEQRGDNALKDARAKLDELEGALHQAKEELARMLREYQELMSLKLALDMEIATYRKLLESEECRMSGEFPSPVSISIISSTSGGSVYGFRPSMVSGGYVANSSNCISGVCSVRGGEGRSRGSANDYKDTLGKGSSLSAPSKKTSR

Target ORF information:

RefSeq Version	NM_033448.3
Organism	Homo sapiens(human)
Definition	Homo sapiens keratin 71 (KRT71), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_033448.3

ORF Insert Sequence:

ATGAGCCGCC AATTCACCTG CAAGTCGGGA GCTGCCGCCA AGGGGGGCTT CAGTGGCTGC 
TCAGCTGTGC TCTCAGGGGG CAGCTCATCC TCCTTCCGGG CAGGGAGCAA AGGGCTCAGT 
GGGGGCTTTG GCAGCCGGAG CCTCTACAGC CTGGGGGGTG TCCGGAGCCT CAATGTGGCC 
AGTGGCAGCG GGAAGAGTGG AGGCTATGGA TTTGGCCGGG GCCGGGCCAG TGGCTTTGCT 
GGAAGCATGT TTGGCAGTGT GGCCCTGGGG CCTGTGTGCC CAACTGTATG CCCACCTGGA 
GGCATCCACC AGGTTACCGT CAATGAGAGC CTCCTGGCCC CCCTCAACGT GGAGCTGGAC 
CCCGAGATCC AGAAAGTGCG TGCCCAGGAG CGAGAGCAGA TCAAGGCTCT GAACAACAAG 
TTCGCCTCCT TCATCGACAA GGTGCGGTTC CTGGAGCAGC AGAACCAGGT ACTGGAGACC 
AAGTGGGAGC TGCTGCAGCA GCTGGACCTG AACAACTGCA AGAACAACCT GGAGCCCATC 
CTCGAGGGCT ACATCAGCAA CCTGCGGAAG CAGCTGGAGA CGCTGTCTGG GGACAGGGTG 
AGGCTGGACT CGGAGCTGAG GAATGTGCGG GACGTAGTGG AGGACTACAA GAAGAGGTAT 
GAGGAGGAAA TCAACAAGCG GACAGCAGCA GAGAACGAGT TTGTGCTGCT CAAGAAGGAT 
GTGGATGCTG CTTACGCCAA TAAGGTGGAA CTGCAGGCCA AGGTGGAATC CATGGACCAG 
GAGATCAAGT TCTTCAGGTG TCTCTTTGAA GCCGAGATCA CTCAGATCCA GTCCCACATC 
AGTGACATGT CTGTCATCCT GTCCATGGAC AACAACCGGA ACCTAGACCT GGACAGCATC 
ATTGACGAAG TCCGCACCCA GTATGAGGAG ATTGCCTTGA AGAGTAAGGC CGAGGCTGAG 
GCCCTGTACC AGACCAAGTT CCAAGAGCTT CAGCTGGCAG CTGGCAGGCA TGGGGACGAC 
CTCAAAAACA CCAAGAATGA AATCTCGGAG CTCACTCGGC TCATCCAGAG AATCCGCTCA 
GAGATCGAGA ACGTGAAGAA GCAGGCTTCC AACCTGGAGA CAGCCATCGC TGATGCTGAG 
CAGCGGGGAG ACAACGCCCT GAAGGATGCC CGGGCCAAGC TGGACGAGCT GGAGGGCGCC 
CTGCACCAGG CCAAGGAGGA GCTGGCGCGG ATGCTGCGCG AGTACCAGGA GCTCATGAGC 
CTGAAGCTGG CCCTGGACAT GGAGATCGCC ACCTATCGCA AGCTACTGGA GAGCGAGGAG 
TGCAGGATGT CAGGAGAATT TCCCTCCCCT GTCAGCATCT CCATCATCAG CAGCACCAGT 
GGCGGCAGTG TCTATGGCTT CCGGCCCAGC ATGGTCAGCG GTGGCTATGT GGCCAACAGC 
AGCAACTGCA TCTCTGGAGT GTGCAGCGTG AGAGGCGGGG AGGGCAGGAG CCGGGGCAGT 
GCCAACGATT ACAAAGACAC CCTAGGGAAG GGTTCCAGCC TGAGTGCACC CTCCAAGAAA 
ACCAGTCGGT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

KRT71 ( XM_017018749.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016874238.1 Homo sapiens keratin 71 (KRT71), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu83485
Clone ID Related Accession (Same CDS sequence)	XM_017018749.1
Accession Version	XM_017018749.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1326bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	keratin, type II cytoskeletal 71 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000012.12) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTTTGGCA GTGTGGCCCT GGGGCCTGTG TGCCCAACTG TATGCCCACC TGGAGGCATC 
CACCAGGTTA CCGTCAATGA GAGCCTCCTG GCCCCCCTCA ACGTGGAGCT GGACCCCGAG 
ATCCAGAAAG TGCGTGCCCA GGAGCGAGAG CAGATCAAGG CTCTGAACAA CAAGTTCGCC 
TCCTTCATCG ACAAGGTGCG GTTCCTGGAG CAGCAGAACC AGGTACTGGA GACCAAGTGG 
GAGCTGCTGC AGCAGCTGGA CCTGAACAAC TGCAAGAACA ACCTGGAGCC CATCCTCGAG 
GGCTACATCA GCAACCTGCG GAAGCAGCTG GAGACGCTGT CTGGGGACAG GGTGAGGCTG 
GACTCGGAGC TGAGGAATGT GCGGGACGTA GTGGAGGACT ACAAGAAGAG GTATGAGGAG 
GAAATCAACA AGCGGACAGC AGCAGAGAAC GAGTTTGTGC TGCTCAAGAA GGATGTGGAT 
GCTGCTTACG CCAATAAGGT GGAACTGCAG GCCAAGGTGG AATCCATGGA CCAGGAGATC 
AAGTTCTTCA GGTGTCTCTT TGAAGCCGAG ATCACTCAGA TCCAGTCCCA CATCAGTGAC 
ATGTCTGTCA TCCTGTCCAT GGACAACAAC CGGAACCTAG ACCTGGACAG CATCATTGAC 
GAAGTCCGCA CCCAGTATGA GGAGATTGCC TTGAAGAGTA AGGCCGAGGC TGAGGCCCTG 
TACCAGACCA AGTTCCAAGA GCTTCAGCTG GCAGCTGGCA GGCATGGGGA CGACCTCAAA 
AACACCAAGA ATGAAATCTC GGAGCTCACT CGGCTCATCC AGAGAATCCG CTCAGAGATC 
GAGAACGTGA AGAAGCAGGC TTCCAACCTG GAGACAGCCA TCGCTGATGC TGAGCAGCGG 
GGAGACAACG CCCTGAAGGA TGCCCGGGCC AAGCTGGACG AGCTGGAGGG CGCCCTGCAC 
CAGGCCAAGG AGGAGCTGGC GCGGATGCTG CGCGAGTACC AGGAGCTCAT GAGCCTGAAG 
CTGGCCCTGG ACATGGAGAT CGCCACCTAT CGCAAGCTAC TGGAGAGCGA GGAGTGCAGG 
ATGTCAGGAG AATTTCCCTC CCCTGTCAGC ATCTCCATCA TCAGCAGCAC CAGTGGCGGC 
AGTGTCTATG GCTTCCGGCC CAGCATGGTC AGCGGTGGCT ATGTGGCCAA CAGCAGCAAC 
TGCATCTCTG GAGTGTGCAG CGTGAGAGGC GGGGAGGGCA GGAGCCGGGG CAGTGCCAAC 
GATTACAAAG ACACCCTAGG GAAGGGTTCC AGCCTGAGTG CACCCTCCAA GAAAACCAGT 
CGGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016874238.1
CDS	190..1515
Translation	MFGSVALGPVCPTVCPPGGIHQVTVNESLLAPLNVELDPEIQKVRAQEREQIKALNNKFASFIDKVRFLEQQNQVLETKWELLQQLDLNNCKNNLEPILEGYISNLRKQLETLSGDRVRLDSELRNVRDVVEDYKKRYEEEINKRTAAENEFVLLKKDVDAAYANKVELQAKVESMDQEIKFFRCLFEAEITQIQSHISDMSVILSMDNNRNLDLDSIIDEVRTQYEEIALKSKAEAEALYQTKFQELQLAAGRHGDDLKNTKNEISELTRLIQRIRSEIENVKKQASNLETAIADAEQRGDNALKDARAKLDELEGALHQAKEELARMLREYQELMSLKLALDMEIATYRKLLESEECRMSGEFPSPVSISIISSTSGGSVYGFRPSMVSGGYVANSSNCISGVCSVRGGEGRSRGSANDYKDTLGKGSSLSAPSKKTSR

Target ORF information:

RefSeq Version	XM_017018749.1
Organism	Homo sapiens(human)
Definition	Homo sapiens keratin 71 (KRT71), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017018749.1

ORF Insert Sequence:

ATGTTTGGCA GTGTGGCCCT GGGGCCTGTG TGCCCAACTG TATGCCCACC TGGAGGCATC 
CACCAGGTTA CCGTCAATGA GAGCCTCCTG GCCCCCCTCA ACGTGGAGCT GGACCCCGAG 
ATCCAGAAAG TGCGTGCCCA GGAGCGAGAG CAGATCAAGG CTCTGAACAA CAAGTTCGCC 
TCCTTCATCG ACAAGGTGCG GTTCCTGGAG CAGCAGAACC AGGTACTGGA GACCAAGTGG 
GAGCTGCTGC AGCAGCTGGA CCTGAACAAC TGCAAGAACA ACCTGGAGCC CATCCTCGAG 
GGCTACATCA GCAACCTGCG GAAGCAGCTG GAGACGCTGT CTGGGGACAG GGTGAGGCTG 
GACTCGGAGC TGAGGAATGT GCGGGACGTA GTGGAGGACT ACAAGAAGAG GTATGAGGAG 
GAAATCAACA AGCGGACAGC AGCAGAGAAC GAGTTTGTGC TGCTCAAGAA GGATGTGGAT 
GCTGCTTACG CCAATAAGGT GGAACTGCAG GCCAAGGTGG AATCCATGGA CCAGGAGATC 
AAGTTCTTCA GGTGTCTCTT TGAAGCCGAG ATCACTCAGA TCCAGTCCCA CATCAGTGAC 
ATGTCTGTCA TCCTGTCCAT GGACAACAAC CGGAACCTAG ACCTGGACAG CATCATTGAC 
GAAGTCCGCA CCCAGTATGA GGAGATTGCC TTGAAGAGTA AGGCCGAGGC TGAGGCCCTG 
TACCAGACCA AGTTCCAAGA GCTTCAGCTG GCAGCTGGCA GGCATGGGGA CGACCTCAAA 
AACACCAAGA ATGAAATCTC GGAGCTCACT CGGCTCATCC AGAGAATCCG CTCAGAGATC 
GAGAACGTGA AGAAGCAGGC TTCCAACCTG GAGACAGCCA TCGCTGATGC TGAGCAGCGG 
GGAGACAACG CCCTGAAGGA TGCCCGGGCC AAGCTGGACG AGCTGGAGGG CGCCCTGCAC 
CAGGCCAAGG AGGAGCTGGC GCGGATGCTG CGCGAGTACC AGGAGCTCAT GAGCCTGAAG 
CTGGCCCTGG ACATGGAGAT CGCCACCTAT CGCAAGCTAC TGGAGAGCGA GGAGTGCAGG 
ATGTCAGGAG AATTTCCCTC CCCTGTCAGC ATCTCCATCA TCAGCAGCAC CAGTGGCGGC 
AGTGTCTATG GCTTCCGGCC CAGCATGGTC AGCGGTGGCT ATGTGGCCAA CAGCAGCAAC 
TGCATCTCTG GAGTGTGCAG CGTGAGAGGC GGGGAGGGCA GGAGCCGGGG CAGTGCCAAC 
GATTACAAAG ACACCCTAGG GAAGGGTTCC AGCCTGAGTG CACCCTCCAA GAAAACCAGT 
CGGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

A missense mutation within the helix initiation motif of the keratin K71 gene underlies autosomal dominant woolly hair/hypotrichosis.
The Journal of investigative dermatology132(10)2342-2349(2012 Oct)
Fujimoto A,Farooq M,Fujikawa H,Inoue A,Ohyama M,Ehama R,Nakanishi J,Hagihara M,Iwabuchi T,Aoki J,Ito M,Shimomura Y

New consensus nomenclature for mammalian keratins.
The Journal of cell biology174(2)169-74(2006 Jul)
Schweizer J,Bowden PE,Coulombe PA,Langbein L,Lane EB,Magin TM,Maltais L,Omary MB,Parry DA,Rogers MA,Wright MW

K6irs1, K6irs2, K6irs3, and K6irs4 represent the inner-root-sheath-specific type II epithelial keratins of the human hair follicle.
The Journal of investigative dermatology120(4)512-22(2003 Apr)
Langbein L,Rogers MA,Praetzel S,Winter H,Schweizer J

A novel epithelial keratin, hK6irs1, is expressed differentially in all layers of the inner root sheath, including specialized huxley cells (Fl?gelzellen) of the human hair follicle.
The Journal of investigative dermatology118(5)789-99(2002 May)
Langbein L,Rogers MA,Praetzel S,Aoki N,Winter H,Schweizer J