TOPBP1 gene cDNA ORF clone, Homo sapiens(human)

mRNA	Protein	Name
XM_017005636.1	XP_016861125.1	DNA topoisomerase 2-binding protein 1 isoform X1
XM_017005637.1	XP_016861126.1	DNA topoisomerase 2-binding protein 1 isoform X4
XM_017005637.2	XP_016861126.1	DNA topoisomerase 2-binding protein 1 isoform X4
XM_011512357.3	XP_011510659.1	DNA topoisomerase 2-binding protein 1 isoform X3
NM_001363889.2	NP_001350818.1	DNA topoisomerase 2-binding protein 1 isoform 2
XM_005247076.3	XP_005247133.1	DNA topoisomerase 2-binding protein 1 isoform X2
XM_017005636.2	XP_016861125.1	DNA topoisomerase 2-binding protein 1 isoform X1
XM_011512357.2	XP_011510659.1	DNA topoisomerase 2-binding protein 1 isoform X3
NM_001363889.1	NP_001350818.1	DNA topoisomerase 2-binding protein 1 isoform 2
NM_007027.3	NP_008958.2	DNA topoisomerase 2-binding protein 1 isoform 1
NM_007027.4	NP_008958.2	DNA topoisomerase 2-binding protein 1 isoform 1

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu16438	NM_007027.4 Latest version!	Homo sapiens DNA topoisomerase II binding protein 1 (TOPBP1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$579.50-$811.30 $1159.00
OHu16438	XM_017005636.2 Latest version!	Homo sapiens DNA topoisomerase II binding protein 1 (TOPBP1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$579.50-$811.30 $1159.00
OHu93765	XM_017005637.2 Latest version!	Homo sapiens DNA topoisomerase II binding protein 1 (TOPBP1), transcript variant X5, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	15-17	$559.30 $799.00
OHu64678	XM_011512357.3 Latest version!	Homo sapiens DNA topoisomerase II binding protein 1 (TOPBP1), transcript variant X4, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	20	$559.30 $799.00
OHu37681	NM_001363889.2 Latest version!	Homo sapiens DNA topoisomerase II binding protein 1 (TOPBP1), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	25	$811.30 $1159.00
OHu37681	XM_005247076.3 Latest version!	Homo sapiens topoisomerase (DNA) II binding protein 1 (TOPBP1), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	25	$811.30 $1159.00
View Old Accession Versions >>
OHu93765	XM_017005637.1	Homo sapiens topoisomerase (DNA) II binding protein 1 (TOPBP1), transcript variant X5, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	15-17	$559.30 $799.00
OHu16438	XM_017005636.1	Homo sapiens topoisomerase (DNA) II binding protein 1 (TOPBP1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$579.50-$811.30 $1159.00
OHu64678	XM_011512357.2	Homo sapiens topoisomerase (DNA) II binding protein 1 (TOPBP1), transcript variant X4, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	20	$559.30 $799.00
OHu37681	NM_001363889.1	Homo sapiens DNA topoisomerase II binding protein 1 (TOPBP1), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	25	$811.30 $1159.00
OHu16438	NM_007027.3	Homo sapiens DNA topoisomerase II binding protein 1 (TOPBP1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$579.50-$811.30 $1159.00
Hide Old Accession Versions >>

TOPBP1 ( NM_007027.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_008958.2 Homo sapiens DNA topoisomerase II binding protein 1 (TOPBP1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu16438
Clone ID Related Accession (Same CDS sequence)	XM_017005636.1 , XM_017005636.2 , NM_007027.3 , NM_007027.4
Accession Version	NM_007027.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 4569bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-17
Organism	Homo sapiens(human)
Product	DNA topoisomerase 2-binding protein 1 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC032633.1, BC126209.1 and BC151237.1. On Jul 25, 2008 this sequence version replaced NM_007027.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC151237.1, SRR1660803.23079.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTCCAGAA ATGACAAAGA ACCGTTTTTT GTGAAGTTTT TAAAGTCTTC AGACAATTCC 
AAATGTTTTT TTAAAGCTCT CGAGTCCATA AAAGAATTCC AATCAGAAGA ATATCTTCAG 
ATTATTACAG AAGAAGAGGC ATTGAAGATA AAGGAGAATG ATAGATCACT TTATATCTGT 
GACCCTTTTA GTGGCGTTGT CTTTGATCAC CTCAAAAAGC TTGGCTGCAG AATTGTTGGT 
CCTCAAGTAG TCATATTTTG TATGCACCAC CAGCGATGTG TCCCAAGAGC CGAACATCCA 
GTTTATAATA TGGTTATGTC TGATGTAACC ATATCTTGTA CAAGTCTGGA AAAAGAAAAA 
AGGGAAGAAG TTCATAAATA TGTACAAATG ATGGGCGGAC GAGTATACAG AGACCTTAAT 
GTATCAGTAA CTCACCTTAT TGCAGGAGAA GTTGGTAGCA AAAAATATTT AGTTGCTGCA 
AACCTGAAGA AACCTATTTT GCTTCCCTCT TGGATAAAAA CACTTTGGGA GAAGTCACAA 
GAGAAAAAAA TAACTAGATA TACTGATATA AACATGGAAG ATTTCAAGTG TCCTATTTTT 
CTTGGTTGCA TAATCTGTGT GACTGGCTTA TGTGGCTTAG ACAGGAAAGA AGTTCAGCAA 
CTCACAGTTA AGCATGGAGG TCAATACATG GGACAATTGA AAATGAATGA ATGTACACAC 
CTCATTGTGC AAGAACCAAA AGGTCAGAAG TATGAGTGTG CCAAGAGATG GAATGTACAC 
TGTGTGACCA CACAGTGGTT TTTTGACAGT ATTGAGAAAG GTTTTTGTCA GGATGAATCC 
ATATACAAGA CAGAACCTAG ACCAGAAGCA AAGACTATGC CCAATTCTTC AACTCCTACC 
AGCCAGATCA ACACAATTGA TAGTCGTACT CTTTCAGATG TCAGCAATAT TTCCAACATA 
AATGCAAGTT GCGTAAGTGA ATCAATATGT AATTCACTTA ACAGCAAACT GGAGCCTACA 
CTTGAAAATC TAGAAAATCT GGATGTCAGT GCATTTCAAG CACCTGAAGA TTTATTAGAT 
GGTTGTCGGA TATATCTTTG CGGTTTTAGT GGCAGAAAGC TAGATAAACT GAGAAGACTT 
ATTAACAGTG GAGGTGGAGT TCGTTTTAAC CAGCTAAATG AAGATGTAAC TCATGTTATT 
GTGGGAGATT ATGATGATGA ATTGAAGCAG TTTTGGAATA AATCAGCCCA CAGGCCTCAT 
GTAGTGGGAG CAAAGTGGTT GCTAGAGTGT TTCAGTAAAG GTTATATGCT TTCTGAAGAA 
CCATATATCC ATGCTAATTA CCAGCCAGTG GAAATTCCAG TTTCACATAA GCCTGAAAGT 
AAAGCAGCTC TTTTAAAAAA GAAGAACAGC AGCTTCTCTA AGAAAGACTT TGCTCCTAGT 
GAAAAGCATG AGCAAGCTGA TGAAGATCTG CTCTCTCAAT ATGAAAATGG TAGCTCCACA 
GTAGTTGAGG CTAAGACGTC TGAAGCCAGG CCCTTTAATG ATTCTACTCA TGCTGAGCCC 
TTGAATGATT CTACTCACAT TTCTTTGCAA GAAGAAAACC AGTCTTCTGT CAGTCATTGT 
GTCCCTGATG TTTCTACAAT TACTGAAGAA GGCTTATTTA GCCAAAAGAG TTTCCTTGTT 
TTGGGTTTTA GTAATGAAAA TGAATCTAAC ATCGCAAACA TCATAAAAGA AAATGCTGGG 
AAAATCATGT CCCTTCTGAG CAGAACTGTT GCGGATTATG CTGTGGTTCC TCTGCTGGGG 
TGTGAAGTGG AAGCCACTGT GGGAGAAGTT GTTACAAATA CATGGCTGGT TACTTGCATA 
GACTATCAGA CTTTGTTTGA TCCAAAGTCG AATCCTCTCT TCACACCAGT TCCAGTAATG 
ACAGGAATGA CTCCTTTAGA GGATTGTGTT ATTTCATTTA GCCAGTGTGC TGGAGCAGAA 
AAAGAGTCTT TAACATTCCT AGCAAACCTC CTTGGAGCAA GTGTTCAAGA ATACTTTGTT 
CGCAAATCCA ATGCAAAGAA AGGCATGTTT GCCAGTACTC ATCTTATACT GAAAGAACGT 
GGTGGCTCTA AATATGAAGC TGCAAAGAAG TGGAATTTAC CTGCCGTTAC TATAGCTTGG 
CTGTTGGAGA CTGCTAGAAC GGGAAAGAGA GCAGACGAAA GCCATTTTCT GATTGAAAAT 
TCAACTAAAG AAGAACGAAG TTTGGAAACA GAAATAACAA ATGGAATCAA TCTAAATTCA 
GATACTGCAG AGCATCCTGG CACACGCCTG CAAACTCACA GAAAAACCGT CGTTACACCT 
TTAGATATGA ACCGCTTTCA GAGTAAAGCT TTCCGTGCTG TGGTCTCACA ACATGCCAGA 
CAGGTCGCAG CCTCCCCAGC AGTAGGACAA CCACTTCAGA AGGAGCCCTC GTTACACCTG 
GATACACCAT CAAAATTCCT GTCCAAGGAC AAACTCTTCA AGCCTTCCTT TGATGTGAAG 
GATGCACTTG CAGCCTTGGA AACTCCAGGA CGTCCCAGCC AACAGAAAAG GAAACCGAGT 
ACGCCACTCT CAGAAGTTAT TGTCAAAAAC TTGCAACTTG CTTTGGCAAA TAGCTCTCGA 
AATGCTGTCG CTCTTTCTGC CAGCCCTCAA CTGAAAGAGG CCCAGTCAGA GAAGGAAGAA 
GCCCCAAAGC CACTTCACAA AGTAGTGGTA TGTGTTAGTA AAAAACTCAG TAAGAAGCAG 
AGTGAACTAA ATGGGATCGC AGCCTCTCTA GGAGCAGATT ACAGGTGGAG TTTTGATGAA 
ACAGTGACTC ATTTCATCTA TCAAGGGCGG CCAAATGACA CTAATCGGGA GTATAAATCT 
GTAAAAGAAA GAGGAGTACA CATTGTTTCC GAGCACTGGC TTTTAGATTG TGCCCAAGAG 
TGTAAACATC TTCCTGAATC TCTTTATCCA CATACTTATA ATCCCAAAAT GAGCTTGGAT 
ATCAGCGCAG TGCAAGATGG CCGGCTCTGT AATAGTCGAC TACTCTCAGC TGTGTCTTCA 
ACAAAGGATG ATGAGCCAGA TCCTTTGATT TTAGAAGAAA ATGATGTAGA CAATATGGCC 
ACCAATAATA AAGAGTCAGC ACCATCAAAT GGAAGTGGAA AGAATGACTC TAAAGGAGTT 
CTGACACAGA CCTTAGAGAT GAGAGAGAAC TTTCAGAAGC AGTTACAGGA GATAATGTCT 
GCAACATCAA TAGTGAAACC CCAAGGGCAG AGGACTTCCC TTTCAAGAAG TGGTTGTAAC 
AGCGCATCTT CAACCCCTGA CAGCACTCGC TCTGCTCGCA GTGGACGAAG TAGAGTCCTA 
GAGGCACTGA GGCAGTCTCG TCAGACAGTA CCTGATGTCA ACACAGAGCC TTCCCAAAAT 
GAACAGATCA TTTGGGATGA CCCTACAGCA AGGGAGGAGA GAGCAAGGCT TGCCAGCAAT 
TTGCAGTGGC CTAGTTGTCC CACACAATAC TCTGAGCTTC AGGTTGACAT TCAAAACTTG 
GAGGATTCTC CTTTTCAAAA GCCTTTACAT GATTCAGAAA TTGCTAAACA GGCTGTCTGT 
GATCCTGGAA ACATACGTGT GACTGAAGCT CCCAAACACC CAATCTCTGA AGAACTGGAA 
ACTCCCATAA AAGACAGCCA CCTGATCCCT ACGCCTCAAG CCCCCAGTAT TGCCTTTCCA 
CTCGCCAACC CCCCTGTGGC TCCGCACCCT AGAGAAAAGA TTATAACGAT AGAGGAGACT 
CATGAAGAAT TAAAAAAACA GTACATATTT CAGTTATCAT CTCTGAATCC TCAAGAACGT 
ATTGACTATT GTCATCTGAT TGAGAAACTA GGTGGATTGG TGATAGAAAA GCAGTGCTTT 
GATCCCACCT GTACACACAT TGTTGTGGGA CATCCACTTC GAAACGAGAA GTATTTAGCC 
TCAGTGGCAG CTGGGAAGTG GGTGCTTCAT CGCTCCTACC TTGAAGCCTG CAGGACTGCT 
GGACACTTCG TGCAGGAAGA AGACTATGAA TGGGGAAGTA GTTCCATACT TGATGTTCTG 
ACTGGAATCA ATGTACAGCA ACGAAGACTA GCACTTGCAG CAATGAGATG GAGAAAAAAA 
ATCCAGCAAA GACAAGAATC TGGCATTGTT GAGGGAGCAT TTAGTGGGTG GAAGGTTATT 
TTACATGTGG ATCAGTCTCG AGAAGCAGGC TTCAAACGCC TTCTTCAGTC AGGAGGAGCA 
AAGGTGCTAC CTGGTCATTC TGTACCTTTA TTTAAAGAGG CCACACATCT TTTTTCTGAC 
TTGAATAAAC TGAAACCAGA TGACTCAGGA GTTAATATAG CAGAAGCTGC TGCCCAGAAC 
GTGTACTGCT TGAGAACAGA ATACATTGCT GATTATCTCA TGCAGGAATC ACCTCCTCAT 
GTAGAAAATT ACTGTCTACC AGAAGCTATT TCATTTATTC AGAATAATAA GGAACTTGGG 
ACTGGATTAT CACAAAAGAG GAAAGCTCCT ACAGAAAAAA ATAAAATCAA ACGACCTAGA 
GTACACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_008958.2
CDS	133..4701
Translation	MSRNDKEPFFVKFLKSSDNSKCFFKALESIKEFQSEEYLQIITEEEALKIKENDRSLYICDPFSGVVFDHLKKLGCRIVGPQVVIFCMHHQRCVPRAEHPVYNMVMSDVTISCTSLEKEKREEVHKYVQMMGGRVYRDLNVSVTHLIAGEVGSKKYLVAANLKKPILLPSWIKTLWEKSQEKKITRYTDINMEDFKCPIFLGCIICVTGLCGLDRKEVQQLTVKHGGQYMGQLKMNECTHLIVQEPKGQKYECAKRWNVHCVTTQWFFDSIEKGFCQDESIYKTEPRPEAKTMPNSSTPTSQINTIDSRTLSDVSNISNINASCVSESICNSLNSKLEPTLENLENLDVSAFQAPEDLLDGCRIYLCGFSGRKLDKLRRLINSGGGVRFNQLNEDVTHVIVGDYDDELKQFWNKSAHRPHVVGAKWLLECFSKGYMLSEEPYIHANYQPVEIPVSHKPESKAALLKKKNSSFSKKDFAPSEKHEQADEDLLSQYENGSSTVVEAKTSEARPFNDSTHAEPLNDSTHISLQEENQSSVSHCVPDVSTITEEGLFSQKSFLVLGFSNENESNIANIIKENAGKIMSLLSRTVADYAVVPLLGCEVEATVGEVVTNTWLVTCIDYQTLFDPKSNPLFTPVPVMTGMTPLEDCVISFSQCAGAEKESLTFLANLLGASVQEYFVRKSNAKKGMFASTHLILKERGGSKYEAAKKWNLPAVTIAWLLETARTGKRADESHFLIENSTKEERSLETEITNGINLNSDTAEHPGTRLQTHRKTVVTPLDMNRFQSKAFRAVVSQHARQVAASPAVGQPLQKEPSLHLDTPSKFLSKDKLFKPSFDVKDALAALETPGRPSQQKRKPSTPLSEVIVKNLQLALANSSRNAVALSASPQLKEAQSEKEEAPKPLHKVVVCVSKKLSKKQSELNGIAASLGADYRWSFDETVTHFIYQGRPNDTNREYKSVKERGVHIVSEHWLLDCAQECKHLPESLYPHTYNPKMSLDISAVQDGRLCNSRLLSAVSSTKDDEPDPLILEENDVDNMATNNKESAPSNGSGKNDSKGVLTQTLEMRENFQKQLQEIMSATSIVKPQGQRTSLSRSGCNSASSTPDSTRSARSGRSRVLEALRQSRQTVPDVNTEPSQNEQIIWDDPTAREERARLASNLQWPSCPTQYSELQVDIQNLEDSPFQKPLHDSEIAKQAVCDPGNIRVTEAPKHPISEELETPIKDSHLIPTPQAPSIAFPLANPPVAPHPREKIITIEETHEELKKQYIFQLSSLNPQERIDYCHLIEKLGGLVIEKQCFDPTCTHIVVGHPLRNEKYLASVAAGKWVLHRSYLEACRTAGHFVQEEDYEWGSSSILDVLTGINVQQRRLALAAMRWRKKIQQRQESGIVEGAFSGWKVILHVDQSREAGFKRLLQSGGAKVLPGHSVPLFKEATHLFSDLNKLKPDDSGVNIAEAAAQNVYCLRTEYIADYLMQESPPHVENYCLPEAISFIQNNKELGTGLSQKRKAPTEKNKIKRPRVH

Target ORF information:

RefSeq Version	NM_007027.3
Organism	Homo sapiens(human)
Definition	Homo sapiens DNA topoisomerase II binding protein 1 (TOPBP1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_007027.3

ORF Insert Sequence:

ATGTCCAGAA ATGACAAAGA ACCGTTTTTT GTGAAGTTTT TAAAGTCTTC AGACAATTCC 
AAATGTTTTT TTAAAGCTCT CGAGTCCATA AAAGAATTCC AATCAGAAGA ATATCTTCAG 
ATTATTACAG AAGAAGAGGC ATTGAAGATA AAGGAGAATG ATAGATCACT TTATATCTGT 
GACCCTTTTA GTGGCGTTGT CTTTGATCAC CTCAAAAAGC TTGGCTGCAG AATTGTTGGT 
CCTCAAGTAG TCATATTTTG TATGCACCAC CAGCGATGTG TCCCAAGAGC CGAACATCCA 
GTTTATAATA TGGTTATGTC TGATGTAACC ATATCTTGTA CAAGTCTGGA AAAAGAAAAA 
AGGGAAGAAG TTCATAAATA TGTACAAATG ATGGGCGGAC GAGTATACAG AGACCTTAAT 
GTATCAGTAA CTCACCTTAT TGCAGGAGAA GTTGGTAGCA AAAAATATTT AGTTGCTGCA 
AACCTGAAGA AACCTATTTT GCTTCCCTCT TGGATAAAAA CACTTTGGGA GAAGTCACAA 
GAGAAAAAAA TAACTAGATA TACTGATATA AACATGGAAG ATTTCAAGTG TCCTATTTTT 
CTTGGTTGCA TAATCTGTGT GACTGGCTTA TGTGGCTTAG ACAGGAAAGA AGTTCAGCAA 
CTCACAGTTA AGCATGGAGG TCAATACATG GGACAATTGA AAATGAATGA ATGTACACAC 
CTCATTGTGC AAGAACCAAA AGGTCAGAAG TATGAGTGTG CCAAGAGATG GAATGTACAC 
TGTGTGACCA CACAGTGGTT TTTTGACAGT ATTGAGAAAG GTTTTTGTCA GGATGAATCC 
ATATACAAGA CAGAACCTAG ACCAGAAGCA AAGACTATGC CCAATTCTTC AACTCCTACC 
AGCCAGATCA ACACAATTGA TAGTCGTACT CTTTCAGATG TCAGCAATAT TTCCAACATA 
AATGCAAGTT GCGTAAGTGA ATCAATATGT AATTCACTTA ACAGCAAACT GGAGCCTACA 
CTTGAAAATC TAGAAAATCT GGATGTCAGT GCATTTCAAG CACCTGAAGA TTTATTAGAT 
GGTTGTCGGA TATATCTTTG CGGTTTTAGT GGCAGAAAGC TAGATAAACT GAGAAGACTT 
ATTAACAGTG GAGGTGGAGT TCGTTTTAAC CAGCTAAATG AAGATGTAAC TCATGTTATT 
GTGGGAGATT ATGATGATGA ATTGAAGCAG TTTTGGAATA AATCAGCCCA CAGGCCTCAT 
GTAGTGGGAG CAAAGTGGTT GCTAGAGTGT TTCAGTAAAG GTTATATGCT TTCTGAAGAA 
CCATATATCC ATGCTAATTA CCAGCCAGTG GAAATTCCAG TTTCACATAA GCCTGAAAGT 
AAAGCAGCTC TTTTAAAAAA GAAGAACAGC AGCTTCTCTA AGAAAGACTT TGCTCCTAGT 
GAAAAGCATG AGCAAGCTGA TGAAGATCTG CTCTCTCAAT ATGAAAATGG TAGCTCCACA 
GTAGTTGAGG CTAAGACGTC TGAAGCCAGG CCCTTTAATG ATTCTACTCA TGCTGAGCCC 
TTGAATGATT CTACTCACAT TTCTTTGCAA GAAGAAAACC AGTCTTCTGT CAGTCATTGT 
GTCCCTGATG TTTCTACAAT TACTGAAGAA GGCTTATTTA GCCAAAAGAG TTTCCTTGTT 
TTGGGTTTTA GTAATGAAAA TGAATCTAAC ATCGCAAACA TCATAAAAGA AAATGCTGGG 
AAAATCATGT CCCTTCTGAG CAGAACTGTT GCGGATTATG CTGTGGTTCC TCTGCTGGGG 
TGTGAAGTGG AAGCCACTGT GGGAGAAGTT GTTACAAATA CATGGCTGGT TACTTGCATA 
GACTATCAGA CTTTGTTTGA TCCAAAGTCG AATCCTCTCT TCACACCAGT TCCAGTAATG 
ACAGGAATGA CTCCTTTAGA GGATTGTGTT ATTTCATTTA GCCAGTGTGC TGGAGCAGAA 
AAAGAGTCTT TAACATTCCT AGCAAACCTC CTTGGAGCAA GTGTTCAAGA ATACTTTGTT 
CGCAAATCCA ATGCAAAGAA AGGCATGTTT GCCAGTACTC ATCTTATACT GAAAGAACGT 
GGTGGCTCTA AATATGAAGC TGCAAAGAAG TGGAATTTAC CTGCCGTTAC TATAGCTTGG 
CTGTTGGAGA CTGCTAGAAC GGGAAAGAGA GCAGACGAAA GCCATTTTCT GATTGAAAAT 
TCAACTAAAG AAGAACGAAG TTTGGAAACA GAAATAACAA ATGGAATCAA TCTAAATTCA 
GATACTGCAG AGCATCCTGG CACACGCCTG CAAACTCACA GAAAAACCGT CGTTACACCT 
TTAGATATGA ACCGCTTTCA GAGTAAAGCT TTCCGTGCTG TGGTCTCACA ACATGCCAGA 
CAGGTCGCAG CCTCCCCAGC AGTAGGACAA CCACTTCAGA AGGAGCCCTC GTTACACCTG 
GATACACCAT CAAAATTCCT GTCCAAGGAC AAACTCTTCA AGCCTTCCTT TGATGTGAAG 
GATGCACTTG CAGCCTTGGA AACTCCAGGA CGTCCCAGCC AACAGAAAAG GAAACCGAGT 
ACGCCACTCT CAGAAGTTAT TGTCAAAAAC TTGCAACTTG CTTTGGCAAA TAGCTCTCGA 
AATGCTGTCG CTCTTTCTGC CAGCCCTCAA CTGAAAGAGG CCCAGTCAGA GAAGGAAGAA 
GCCCCAAAGC CACTTCACAA AGTAGTGGTA TGTGTTAGTA AAAAACTCAG TAAGAAGCAG 
AGTGAACTAA ATGGGATCGC AGCCTCTCTA GGAGCAGATT ACAGGTGGAG TTTTGATGAA 
ACAGTGACTC ATTTCATCTA TCAAGGGCGG CCAAATGACA CTAATCGGGA GTATAAATCT 
GTAAAAGAAA GAGGAGTACA CATTGTTTCC GAGCACTGGC TTTTAGATTG TGCCCAAGAG 
TGTAAACATC TTCCTGAATC TCTTTATCCA CATACTTATA ATCCCAAAAT GAGCTTGGAT 
ATCAGCGCAG TGCAAGATGG CCGGCTCTGT AATAGTCGAC TACTCTCAGC TGTGTCTTCA 
ACAAAGGATG ATGAGCCAGA TCCTTTGATT TTAGAAGAAA ATGATGTAGA CAATATGGCC 
ACCAATAATA AAGAGTCAGC ACCATCAAAT GGAAGTGGAA AGAATGACTC TAAAGGAGTT 
CTGACACAGA CCTTAGAGAT GAGAGAGAAC TTTCAGAAGC AGTTACAGGA GATAATGTCT 
GCAACATCAA TAGTGAAACC CCAAGGGCAG AGGACTTCCC TTTCAAGAAG TGGTTGTAAC 
AGCGCATCTT CAACCCCTGA CAGCACTCGC TCTGCTCGCA GTGGACGAAG TAGAGTCCTA 
GAGGCACTGA GGCAGTCTCG TCAGACAGTA CCTGATGTCA ACACAGAGCC TTCCCAAAAT 
GAACAGATCA TTTGGGATGA CCCTACAGCA AGGGAGGAGA GAGCAAGGCT TGCCAGCAAT 
TTGCAGTGGC CTAGTTGTCC CACACAATAC TCTGAGCTTC AGGTTGACAT TCAAAACTTG 
GAGGATTCTC CTTTTCAAAA GCCTTTACAT GATTCAGAAA TTGCTAAACA GGCTGTCTGT 
GATCCTGGAA ACATACGTGT GACTGAAGCT CCCAAACACC CAATCTCTGA AGAACTGGAA 
ACTCCCATAA AAGACAGCCA CCTGATCCCT ACGCCTCAAG CCCCCAGTAT TGCCTTTCCA 
CTCGCCAACC CCCCTGTGGC TCCGCACCCT AGAGAAAAGA TTATAACGAT AGAGGAGACT 
CATGAAGAAT TAAAAAAACA GTACATATTT CAGTTATCAT CTCTGAATCC TCAAGAACGT 
ATTGACTATT GTCATCTGAT TGAGAAACTA GGTGGATTGG TGATAGAAAA GCAGTGCTTT 
GATCCCACCT GTACACACAT TGTTGTGGGA CATCCACTTC GAAACGAGAA GTATTTAGCC 
TCAGTGGCAG CTGGGAAGTG GGTGCTTCAT CGCTCCTACC TTGAAGCCTG CAGGACTGCT 
GGACACTTCG TGCAGGAAGA AGACTATGAA TGGGGAAGTA GTTCCATACT TGATGTTCTG 
ACTGGAATCA ATGTACAGCA ACGAAGACTA GCACTTGCAG CAATGAGATG GAGAAAAAAA 
ATCCAGCAAA GACAAGAATC TGGCATTGTT GAGGGAGCAT TTAGTGGGTG GAAGGTTATT 
TTACATGTGG ATCAGTCTCG AGAAGCAGGC TTCAAACGCC TTCTTCAGTC AGGAGGAGCA 
AAGGTGCTAC CTGGTCATTC TGTACCTTTA TTTAAAGAGG CCACACATCT TTTTTCTGAC 
TTGAATAAAC TGAAACCAGA TGACTCAGGA GTTAATATAG CAGAAGCTGC TGCCCAGAAC 
GTGTACTGCT TGAGAACAGA ATACATTGCT GATTATCTCA TGCAGGAATC ACCTCCTCAT 
GTAGAAAATT ACTGTCTACC AGAAGCTATT TCATTTATTC AGAATAATAA GGAACTTGGG 
ACTGGATTAT CACAAAAGAG GAAAGCTCCT ACAGAAAAAA ATAAAATCAA ACGACCTAGA 
GTACACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TOPBP1 ( NM_007027.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_008958.2 Homo sapiens DNA topoisomerase II binding protein 1 (TOPBP1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu16438
Clone ID Related Accession (Same CDS sequence)	XM_017005636.1 , XM_017005636.2 , NM_007027.3 , NM_007027.4
Accession Version	NM_007027.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 4569bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-15
Organism	Homo sapiens(human)
Product	DNA topoisomerase 2-binding protein 1 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC083905.20, BC032633.1, BC126209.1, BC151237.1 and AC016255.24. On May 17, 2019 this sequence version replaced NM_007027.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803614.145815.1, SRR1660803.23079.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000260810.10/ ENSP00000260810.5 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGTCCAGAA ATGACAAAGA ACCGTTTTTT GTGAAGTTTT TAAAGTCTTC AGACAATTCC 
AAATGTTTTT TTAAAGCTCT CGAGTCCATA AAAGAATTCC AATCAGAAGA ATATCTTCAG 
ATTATTACAG AAGAAGAGGC ATTGAAGATA AAGGAGAATG ATAGATCACT TTATATCTGT 
GACCCTTTTA GTGGCGTTGT CTTTGATCAC CTCAAAAAGC TTGGCTGCAG AATTGTTGGT 
CCTCAAGTAG TCATATTTTG TATGCACCAC CAGCGATGTG TCCCAAGAGC CGAACATCCA 
GTTTATAATA TGGTTATGTC TGATGTAACC ATATCTTGTA CAAGTCTGGA AAAAGAAAAA 
AGGGAAGAAG TTCATAAATA TGTACAAATG ATGGGCGGAC GAGTATACAG AGACCTTAAT 
GTATCAGTAA CTCACCTTAT TGCAGGAGAA GTTGGTAGCA AAAAATATTT AGTTGCTGCA 
AACCTGAAGA AACCTATTTT GCTTCCCTCT TGGATAAAAA CACTTTGGGA GAAGTCACAA 
GAGAAAAAAA TAACTAGATA TACTGATATA AACATGGAAG ATTTCAAGTG TCCTATTTTT 
CTTGGTTGCA TAATCTGTGT GACTGGCTTA TGTGGCTTAG ACAGGAAAGA AGTTCAGCAA 
CTCACAGTTA AGCATGGAGG TCAATACATG GGACAATTGA AAATGAATGA ATGTACACAC 
CTCATTGTGC AAGAACCAAA AGGTCAGAAG TATGAGTGTG CCAAGAGATG GAATGTACAC 
TGTGTGACCA CACAGTGGTT TTTTGACAGT ATTGAGAAAG GTTTTTGTCA GGATGAATCC 
ATATACAAGA CAGAACCTAG ACCAGAAGCA AAGACTATGC CCAATTCTTC AACTCCTACC 
AGCCAGATCA ACACAATTGA TAGTCGTACT CTTTCAGATG TCAGCAATAT TTCCAACATA 
AATGCAAGTT GCGTAAGTGA ATCAATATGT AATTCACTTA ACAGCAAACT GGAGCCTACA 
CTTGAAAATC TAGAAAATCT GGATGTCAGT GCATTTCAAG CACCTGAAGA TTTATTAGAT 
GGTTGTCGGA TATATCTTTG CGGTTTTAGT GGCAGAAAGC TAGATAAACT GAGAAGACTT 
ATTAACAGTG GAGGTGGAGT TCGTTTTAAC CAGCTAAATG AAGATGTAAC TCATGTTATT 
GTGGGAGATT ATGATGATGA ATTGAAGCAG TTTTGGAATA AATCAGCCCA CAGGCCTCAT 
GTAGTGGGAG CAAAGTGGTT GCTAGAGTGT TTCAGTAAAG GTTATATGCT TTCTGAAGAA 
CCATATATCC ATGCTAATTA CCAGCCAGTG GAAATTCCAG TTTCACATAA GCCTGAAAGT 
AAAGCAGCTC TTTTAAAAAA GAAGAACAGC AGCTTCTCTA AGAAAGACTT TGCTCCTAGT 
GAAAAGCATG AGCAAGCTGA TGAAGATCTG CTCTCTCAAT ATGAAAATGG TAGCTCCACA 
GTAGTTGAGG CTAAGACGTC TGAAGCCAGG CCCTTTAATG ATTCTACTCA TGCTGAGCCC 
TTGAATGATT CTACTCACAT TTCTTTGCAA GAAGAAAACC AGTCTTCTGT CAGTCATTGT 
GTCCCTGATG TTTCTACAAT TACTGAAGAA GGCTTATTTA GCCAAAAGAG TTTCCTTGTT 
TTGGGTTTTA GTAATGAAAA TGAATCTAAC ATCGCAAACA TCATAAAAGA AAATGCTGGG 
AAAATCATGT CCCTTCTGAG CAGAACTGTT GCGGATTATG CTGTGGTTCC TCTGCTGGGG 
TGTGAAGTGG AAGCCACTGT GGGAGAAGTT GTTACAAATA CATGGCTGGT TACTTGCATA 
GACTATCAGA CTTTGTTTGA TCCAAAGTCG AATCCTCTCT TCACACCAGT TCCAGTAATG 
ACAGGAATGA CTCCTTTAGA GGATTGTGTT ATTTCATTTA GCCAGTGTGC TGGAGCAGAA 
AAAGAGTCTT TAACATTCCT AGCAAACCTC CTTGGAGCAA GTGTTCAAGA ATACTTTGTT 
CGCAAATCCA ATGCAAAGAA AGGCATGTTT GCCAGTACTC ATCTTATACT GAAAGAACGT 
GGTGGCTCTA AATATGAAGC TGCAAAGAAG TGGAATTTAC CTGCCGTTAC TATAGCTTGG 
CTGTTGGAGA CTGCTAGAAC GGGAAAGAGA GCAGACGAAA GCCATTTTCT GATTGAAAAT 
TCAACTAAAG AAGAACGAAG TTTGGAAACA GAAATAACAA ATGGAATCAA TCTAAATTCA 
GATACTGCAG AGCATCCTGG CACACGCCTG CAAACTCACA GAAAAACCGT CGTTACACCT 
TTAGATATGA ACCGCTTTCA GAGTAAAGCT TTCCGTGCTG TGGTCTCACA ACATGCCAGA 
CAGGTCGCAG CCTCCCCAGC AGTAGGACAA CCACTTCAGA AGGAGCCCTC GTTACACCTG 
GATACACCAT CAAAATTCCT GTCCAAGGAC AAACTCTTCA AGCCTTCCTT TGATGTGAAG 
GATGCACTTG CAGCCTTGGA AACTCCAGGA CGTCCCAGCC AACAGAAAAG GAAACCGAGT 
ACGCCACTCT CAGAAGTTAT TGTCAAAAAC TTGCAACTTG CTTTGGCAAA TAGCTCTCGA 
AATGCTGTCG CTCTTTCTGC CAGCCCTCAA CTGAAAGAGG CCCAGTCAGA GAAGGAAGAA 
GCCCCAAAGC CACTTCACAA AGTAGTGGTA TGTGTTAGTA AAAAACTCAG TAAGAAGCAG 
AGTGAACTAA ATGGGATCGC AGCCTCTCTA GGAGCAGATT ACAGGTGGAG TTTTGATGAA 
ACAGTGACTC ATTTCATCTA TCAAGGGCGG CCAAATGACA CTAATCGGGA GTATAAATCT 
GTAAAAGAAA GAGGAGTACA CATTGTTTCC GAGCACTGGC TTTTAGATTG TGCCCAAGAG 
TGTAAACATC TTCCTGAATC TCTTTATCCA CATACTTATA ATCCCAAAAT GAGCTTGGAT 
ATCAGCGCAG TGCAAGATGG CCGGCTCTGT AATAGTCGAC TACTCTCAGC TGTGTCTTCA 
ACAAAGGATG ATGAGCCAGA TCCTTTGATT TTAGAAGAAA ATGATGTAGA CAATATGGCC 
ACCAATAATA AAGAGTCAGC ACCATCAAAT GGAAGTGGAA AGAATGACTC TAAAGGAGTT 
CTGACACAGA CCTTAGAGAT GAGAGAGAAC TTTCAGAAGC AGTTACAGGA GATAATGTCT 
GCAACATCAA TAGTGAAACC CCAAGGGCAG AGGACTTCCC TTTCAAGAAG TGGTTGTAAC 
AGCGCATCTT CAACCCCTGA CAGCACTCGC TCTGCTCGCA GTGGACGAAG TAGAGTCCTA 
GAGGCACTGA GGCAGTCTCG TCAGACAGTA CCTGATGTCA ACACAGAGCC TTCCCAAAAT 
GAACAGATCA TTTGGGATGA CCCTACAGCA AGGGAGGAGA GAGCAAGGCT TGCCAGCAAT 
TTGCAGTGGC CTAGTTGTCC CACACAATAC TCTGAGCTTC AGGTTGACAT TCAAAACTTG 
GAGGATTCTC CTTTTCAAAA GCCTTTACAT GATTCAGAAA TTGCTAAACA GGCTGTCTGT 
GATCCTGGAA ACATACGTGT GACTGAAGCT CCCAAACACC CAATCTCTGA AGAACTGGAA 
ACTCCCATAA AAGACAGCCA CCTGATCCCT ACGCCTCAAG CCCCCAGTAT TGCCTTTCCA 
CTCGCCAACC CCCCTGTGGC TCCGCACCCT AGAGAAAAGA TTATAACGAT AGAGGAGACT 
CATGAAGAAT TAAAAAAACA GTACATATTT CAGTTATCAT CTCTGAATCC TCAAGAACGT 
ATTGACTATT GTCATCTGAT TGAGAAACTA GGTGGATTGG TGATAGAAAA GCAGTGCTTT 
GATCCCACCT GTACACACAT TGTTGTGGGA CATCCACTTC GAAACGAGAA GTATTTAGCC 
TCAGTGGCAG CTGGGAAGTG GGTGCTTCAT CGCTCCTACC TTGAAGCCTG CAGGACTGCT 
GGACACTTCG TGCAGGAAGA AGACTATGAA TGGGGAAGTA GTTCCATACT TGATGTTCTG 
ACTGGAATCA ATGTACAGCA ACGAAGACTA GCACTTGCAG CAATGAGATG GAGAAAAAAA 
ATCCAGCAAA GACAAGAATC TGGCATTGTT GAGGGAGCAT TTAGTGGGTG GAAGGTTATT 
TTACATGTGG ATCAGTCTCG AGAAGCAGGC TTCAAACGCC TTCTTCAGTC AGGAGGAGCA 
AAGGTGCTAC CTGGTCATTC TGTACCTTTA TTTAAAGAGG CCACACATCT TTTTTCTGAC 
TTGAATAAAC TGAAACCAGA TGACTCAGGA GTTAATATAG CAGAAGCTGC TGCCCAGAAC 
GTGTACTGCT TGAGAACAGA ATACATTGCT GATTATCTCA TGCAGGAATC ACCTCCTCAT 
GTAGAAAATT ACTGTCTACC AGAAGCTATT TCATTTATTC AGAATAATAA GGAACTTGGG 
ACTGGATTAT CACAAAAGAG GAAAGCTCCT ACAGAAAAAA ATAAAATCAA ACGACCTAGA 
GTACACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_008958.2
CDS	181..4749
Translation	MSRNDKEPFFVKFLKSSDNSKCFFKALESIKEFQSEEYLQIITEEEALKIKENDRSLYICDPFSGVVFDHLKKLGCRIVGPQVVIFCMHHQRCVPRAEHPVYNMVMSDVTISCTSLEKEKREEVHKYVQMMGGRVYRDLNVSVTHLIAGEVGSKKYLVAANLKKPILLPSWIKTLWEKSQEKKITRYTDINMEDFKCPIFLGCIICVTGLCGLDRKEVQQLTVKHGGQYMGQLKMNECTHLIVQEPKGQKYECAKRWNVHCVTTQWFFDSIEKGFCQDESIYKTEPRPEAKTMPNSSTPTSQINTIDSRTLSDVSNISNINASCVSESICNSLNSKLEPTLENLENLDVSAFQAPEDLLDGCRIYLCGFSGRKLDKLRRLINSGGGVRFNQLNEDVTHVIVGDYDDELKQFWNKSAHRPHVVGAKWLLECFSKGYMLSEEPYIHANYQPVEIPVSHKPESKAALLKKKNSSFSKKDFAPSEKHEQADEDLLSQYENGSSTVVEAKTSEARPFNDSTHAEPLNDSTHISLQEENQSSVSHCVPDVSTITEEGLFSQKSFLVLGFSNENESNIANIIKENAGKIMSLLSRTVADYAVVPLLGCEVEATVGEVVTNTWLVTCIDYQTLFDPKSNPLFTPVPVMTGMTPLEDCVISFSQCAGAEKESLTFLANLLGASVQEYFVRKSNAKKGMFASTHLILKERGGSKYEAAKKWNLPAVTIAWLLETARTGKRADESHFLIENSTKEERSLETEITNGINLNSDTAEHPGTRLQTHRKTVVTPLDMNRFQSKAFRAVVSQHARQVAASPAVGQPLQKEPSLHLDTPSKFLSKDKLFKPSFDVKDALAALETPGRPSQQKRKPSTPLSEVIVKNLQLALANSSRNAVALSASPQLKEAQSEKEEAPKPLHKVVVCVSKKLSKKQSELNGIAASLGADYRWSFDETVTHFIYQGRPNDTNREYKSVKERGVHIVSEHWLLDCAQECKHLPESLYPHTYNPKMSLDISAVQDGRLCNSRLLSAVSSTKDDEPDPLILEENDVDNMATNNKESAPSNGSGKNDSKGVLTQTLEMRENFQKQLQEIMSATSIVKPQGQRTSLSRSGCNSASSTPDSTRSARSGRSRVLEALRQSRQTVPDVNTEPSQNEQIIWDDPTAREERARLASNLQWPSCPTQYSELQVDIQNLEDSPFQKPLHDSEIAKQAVCDPGNIRVTEAPKHPISEELETPIKDSHLIPTPQAPSIAFPLANPPVAPHPREKIITIEETHEELKKQYIFQLSSLNPQERIDYCHLIEKLGGLVIEKQCFDPTCTHIVVGHPLRNEKYLASVAAGKWVLHRSYLEACRTAGHFVQEEDYEWGSSSILDVLTGINVQQRRLALAAMRWRKKIQQRQESGIVEGAFSGWKVILHVDQSREAGFKRLLQSGGAKVLPGHSVPLFKEATHLFSDLNKLKPDDSGVNIAEAAAQNVYCLRTEYIADYLMQESPPHVENYCLPEAISFIQNNKELGTGLSQKRKAPTEKNKIKRPRVH

Target ORF information:

RefSeq Version	NM_007027.4
Organism	Homo sapiens(human)
Definition	Homo sapiens DNA topoisomerase II binding protein 1 (TOPBP1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_007027.4

ORF Insert Sequence:

ATGTCCAGAA ATGACAAAGA ACCGTTTTTT GTGAAGTTTT TAAAGTCTTC AGACAATTCC 
AAATGTTTTT TTAAAGCTCT CGAGTCCATA AAAGAATTCC AATCAGAAGA ATATCTTCAG 
ATTATTACAG AAGAAGAGGC ATTGAAGATA AAGGAGAATG ATAGATCACT TTATATCTGT 
GACCCTTTTA GTGGCGTTGT CTTTGATCAC CTCAAAAAGC TTGGCTGCAG AATTGTTGGT 
CCTCAAGTAG TCATATTTTG TATGCACCAC CAGCGATGTG TCCCAAGAGC CGAACATCCA 
GTTTATAATA TGGTTATGTC TGATGTAACC ATATCTTGTA CAAGTCTGGA AAAAGAAAAA 
AGGGAAGAAG TTCATAAATA TGTACAAATG ATGGGCGGAC GAGTATACAG AGACCTTAAT 
GTATCAGTAA CTCACCTTAT TGCAGGAGAA GTTGGTAGCA AAAAATATTT AGTTGCTGCA 
AACCTGAAGA AACCTATTTT GCTTCCCTCT TGGATAAAAA CACTTTGGGA GAAGTCACAA 
GAGAAAAAAA TAACTAGATA TACTGATATA AACATGGAAG ATTTCAAGTG TCCTATTTTT 
CTTGGTTGCA TAATCTGTGT GACTGGCTTA TGTGGCTTAG ACAGGAAAGA AGTTCAGCAA 
CTCACAGTTA AGCATGGAGG TCAATACATG GGACAATTGA AAATGAATGA ATGTACACAC 
CTCATTGTGC AAGAACCAAA AGGTCAGAAG TATGAGTGTG CCAAGAGATG GAATGTACAC 
TGTGTGACCA CACAGTGGTT TTTTGACAGT ATTGAGAAAG GTTTTTGTCA GGATGAATCC 
ATATACAAGA CAGAACCTAG ACCAGAAGCA AAGACTATGC CCAATTCTTC AACTCCTACC 
AGCCAGATCA ACACAATTGA TAGTCGTACT CTTTCAGATG TCAGCAATAT TTCCAACATA 
AATGCAAGTT GCGTAAGTGA ATCAATATGT AATTCACTTA ACAGCAAACT GGAGCCTACA 
CTTGAAAATC TAGAAAATCT GGATGTCAGT GCATTTCAAG CACCTGAAGA TTTATTAGAT 
GGTTGTCGGA TATATCTTTG CGGTTTTAGT GGCAGAAAGC TAGATAAACT GAGAAGACTT 
ATTAACAGTG GAGGTGGAGT TCGTTTTAAC CAGCTAAATG AAGATGTAAC TCATGTTATT 
GTGGGAGATT ATGATGATGA ATTGAAGCAG TTTTGGAATA AATCAGCCCA CAGGCCTCAT 
GTAGTGGGAG CAAAGTGGTT GCTAGAGTGT TTCAGTAAAG GTTATATGCT TTCTGAAGAA 
CCATATATCC ATGCTAATTA CCAGCCAGTG GAAATTCCAG TTTCACATAA GCCTGAAAGT 
AAAGCAGCTC TTTTAAAAAA GAAGAACAGC AGCTTCTCTA AGAAAGACTT TGCTCCTAGT 
GAAAAGCATG AGCAAGCTGA TGAAGATCTG CTCTCTCAAT ATGAAAATGG TAGCTCCACA 
GTAGTTGAGG CTAAGACGTC TGAAGCCAGG CCCTTTAATG ATTCTACTCA TGCTGAGCCC 
TTGAATGATT CTACTCACAT TTCTTTGCAA GAAGAAAACC AGTCTTCTGT CAGTCATTGT 
GTCCCTGATG TTTCTACAAT TACTGAAGAA GGCTTATTTA GCCAAAAGAG TTTCCTTGTT 
TTGGGTTTTA GTAATGAAAA TGAATCTAAC ATCGCAAACA TCATAAAAGA AAATGCTGGG 
AAAATCATGT CCCTTCTGAG CAGAACTGTT GCGGATTATG CTGTGGTTCC TCTGCTGGGG 
TGTGAAGTGG AAGCCACTGT GGGAGAAGTT GTTACAAATA CATGGCTGGT TACTTGCATA 
GACTATCAGA CTTTGTTTGA TCCAAAGTCG AATCCTCTCT TCACACCAGT TCCAGTAATG 
ACAGGAATGA CTCCTTTAGA GGATTGTGTT ATTTCATTTA GCCAGTGTGC TGGAGCAGAA 
AAAGAGTCTT TAACATTCCT AGCAAACCTC CTTGGAGCAA GTGTTCAAGA ATACTTTGTT 
CGCAAATCCA ATGCAAAGAA AGGCATGTTT GCCAGTACTC ATCTTATACT GAAAGAACGT 
GGTGGCTCTA AATATGAAGC TGCAAAGAAG TGGAATTTAC CTGCCGTTAC TATAGCTTGG 
CTGTTGGAGA CTGCTAGAAC GGGAAAGAGA GCAGACGAAA GCCATTTTCT GATTGAAAAT 
TCAACTAAAG AAGAACGAAG TTTGGAAACA GAAATAACAA ATGGAATCAA TCTAAATTCA 
GATACTGCAG AGCATCCTGG CACACGCCTG CAAACTCACA GAAAAACCGT CGTTACACCT 
TTAGATATGA ACCGCTTTCA GAGTAAAGCT TTCCGTGCTG TGGTCTCACA ACATGCCAGA 
CAGGTCGCAG CCTCCCCAGC AGTAGGACAA CCACTTCAGA AGGAGCCCTC GTTACACCTG 
GATACACCAT CAAAATTCCT GTCCAAGGAC AAACTCTTCA AGCCTTCCTT TGATGTGAAG 
GATGCACTTG CAGCCTTGGA AACTCCAGGA CGTCCCAGCC AACAGAAAAG GAAACCGAGT 
ACGCCACTCT CAGAAGTTAT TGTCAAAAAC TTGCAACTTG CTTTGGCAAA TAGCTCTCGA 
AATGCTGTCG CTCTTTCTGC CAGCCCTCAA CTGAAAGAGG CCCAGTCAGA GAAGGAAGAA 
GCCCCAAAGC CACTTCACAA AGTAGTGGTA TGTGTTAGTA AAAAACTCAG TAAGAAGCAG 
AGTGAACTAA ATGGGATCGC AGCCTCTCTA GGAGCAGATT ACAGGTGGAG TTTTGATGAA 
ACAGTGACTC ATTTCATCTA TCAAGGGCGG CCAAATGACA CTAATCGGGA GTATAAATCT 
GTAAAAGAAA GAGGAGTACA CATTGTTTCC GAGCACTGGC TTTTAGATTG TGCCCAAGAG 
TGTAAACATC TTCCTGAATC TCTTTATCCA CATACTTATA ATCCCAAAAT GAGCTTGGAT 
ATCAGCGCAG TGCAAGATGG CCGGCTCTGT AATAGTCGAC TACTCTCAGC TGTGTCTTCA 
ACAAAGGATG ATGAGCCAGA TCCTTTGATT TTAGAAGAAA ATGATGTAGA CAATATGGCC 
ACCAATAATA AAGAGTCAGC ACCATCAAAT GGAAGTGGAA AGAATGACTC TAAAGGAGTT 
CTGACACAGA CCTTAGAGAT GAGAGAGAAC TTTCAGAAGC AGTTACAGGA GATAATGTCT 
GCAACATCAA TAGTGAAACC CCAAGGGCAG AGGACTTCCC TTTCAAGAAG TGGTTGTAAC 
AGCGCATCTT CAACCCCTGA CAGCACTCGC TCTGCTCGCA GTGGACGAAG TAGAGTCCTA 
GAGGCACTGA GGCAGTCTCG TCAGACAGTA CCTGATGTCA ACACAGAGCC TTCCCAAAAT 
GAACAGATCA TTTGGGATGA CCCTACAGCA AGGGAGGAGA GAGCAAGGCT TGCCAGCAAT 
TTGCAGTGGC CTAGTTGTCC CACACAATAC TCTGAGCTTC AGGTTGACAT TCAAAACTTG 
GAGGATTCTC CTTTTCAAAA GCCTTTACAT GATTCAGAAA TTGCTAAACA GGCTGTCTGT 
GATCCTGGAA ACATACGTGT GACTGAAGCT CCCAAACACC CAATCTCTGA AGAACTGGAA 
ACTCCCATAA AAGACAGCCA CCTGATCCCT ACGCCTCAAG CCCCCAGTAT TGCCTTTCCA 
CTCGCCAACC CCCCTGTGGC TCCGCACCCT AGAGAAAAGA TTATAACGAT AGAGGAGACT 
CATGAAGAAT TAAAAAAACA GTACATATTT CAGTTATCAT CTCTGAATCC TCAAGAACGT 
ATTGACTATT GTCATCTGAT TGAGAAACTA GGTGGATTGG TGATAGAAAA GCAGTGCTTT 
GATCCCACCT GTACACACAT TGTTGTGGGA CATCCACTTC GAAACGAGAA GTATTTAGCC 
TCAGTGGCAG CTGGGAAGTG GGTGCTTCAT CGCTCCTACC TTGAAGCCTG CAGGACTGCT 
GGACACTTCG TGCAGGAAGA AGACTATGAA TGGGGAAGTA GTTCCATACT TGATGTTCTG 
ACTGGAATCA ATGTACAGCA ACGAAGACTA GCACTTGCAG CAATGAGATG GAGAAAAAAA 
ATCCAGCAAA GACAAGAATC TGGCATTGTT GAGGGAGCAT TTAGTGGGTG GAAGGTTATT 
TTACATGTGG ATCAGTCTCG AGAAGCAGGC TTCAAACGCC TTCTTCAGTC AGGAGGAGCA 
AAGGTGCTAC CTGGTCATTC TGTACCTTTA TTTAAAGAGG CCACACATCT TTTTTCTGAC 
TTGAATAAAC TGAAACCAGA TGACTCAGGA GTTAATATAG CAGAAGCTGC TGCCCAGAAC 
GTGTACTGCT TGAGAACAGA ATACATTGCT GATTATCTCA TGCAGGAATC ACCTCCTCAT 
GTAGAAAATT ACTGTCTACC AGAAGCTATT TCATTTATTC AGAATAATAA GGAACTTGGG 
ACTGGATTAT CACAAAAGAG GAAAGCTCCT ACAGAAAAAA ATAAAATCAA ACGACCTAGA 
GTACACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TOPBP1 ( XM_017005636.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016861125.1 Homo sapiens topoisomerase (DNA) II binding protein 1 (TOPBP1), transcript variant X1, mRNA.

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CloneID	OHu16438
Clone ID Related Accession (Same CDS sequence)	XM_017005636.1 , XM_017005636.2 , NM_007027.3 , NM_007027.4
Accession Version	XM_017005636.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 4569bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-05
Organism	Homo sapiens(human)
Product	DNA topoisomerase 2-binding protein 1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000003.12) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTCCAGAA ATGACAAAGA ACCGTTTTTT GTGAAGTTTT TAAAGTCTTC AGACAATTCC 
AAATGTTTTT TTAAAGCTCT CGAGTCCATA AAAGAATTCC AATCAGAAGA ATATCTTCAG 
ATTATTACAG AAGAAGAGGC ATTGAAGATA AAGGAGAATG ATAGATCACT TTATATCTGT 
GACCCTTTTA GTGGCGTTGT CTTTGATCAC CTCAAAAAGC TTGGCTGCAG AATTGTTGGT 
CCTCAAGTAG TCATATTTTG TATGCACCAC CAGCGATGTG TCCCAAGAGC CGAACATCCA 
GTTTATAATA TGGTTATGTC TGATGTAACC ATATCTTGTA CAAGTCTGGA AAAAGAAAAA 
AGGGAAGAAG TTCATAAATA TGTACAAATG ATGGGCGGAC GAGTATACAG AGACCTTAAT 
GTATCAGTAA CTCACCTTAT TGCAGGAGAA GTTGGTAGCA AAAAATATTT AGTTGCTGCA 
AACCTGAAGA AACCTATTTT GCTTCCCTCT TGGATAAAAA CACTTTGGGA GAAGTCACAA 
GAGAAAAAAA TAACTAGATA TACTGATATA AACATGGAAG ATTTCAAGTG TCCTATTTTT 
CTTGGTTGCA TAATCTGTGT GACTGGCTTA TGTGGCTTAG ACAGGAAAGA AGTTCAGCAA 
CTCACAGTTA AGCATGGAGG TCAATACATG GGACAATTGA AAATGAATGA ATGTACACAC 
CTCATTGTGC AAGAACCAAA AGGTCAGAAG TATGAGTGTG CCAAGAGATG GAATGTACAC 
TGTGTGACCA CACAGTGGTT TTTTGACAGT ATTGAGAAAG GTTTTTGTCA GGATGAATCC 
ATATACAAGA CAGAACCTAG ACCAGAAGCA AAGACTATGC CCAATTCTTC AACTCCTACC 
AGCCAGATCA ACACAATTGA TAGTCGTACT CTTTCAGATG TCAGCAATAT TTCCAACATA 
AATGCAAGTT GCGTAAGTGA ATCAATATGT AATTCACTTA ACAGCAAACT GGAGCCTACA 
CTTGAAAATC TAGAAAATCT GGATGTCAGT GCATTTCAAG CACCTGAAGA TTTATTAGAT 
GGTTGTCGGA TATATCTTTG CGGTTTTAGT GGCAGAAAGC TAGATAAACT GAGAAGACTT 
ATTAACAGTG GAGGTGGAGT TCGTTTTAAC CAGCTAAATG AAGATGTAAC TCATGTTATT 
GTGGGAGATT ATGATGATGA ATTGAAGCAG TTTTGGAATA AATCAGCCCA CAGGCCTCAT 
GTAGTGGGAG CAAAGTGGTT GCTAGAGTGT TTCAGTAAAG GTTATATGCT TTCTGAAGAA 
CCATATATCC ATGCTAATTA CCAGCCAGTG GAAATTCCAG TTTCACATAA GCCTGAAAGT 
AAAGCAGCTC TTTTAAAAAA GAAGAACAGC AGCTTCTCTA AGAAAGACTT TGCTCCTAGT 
GAAAAGCATG AGCAAGCTGA TGAAGATCTG CTCTCTCAAT ATGAAAATGG TAGCTCCACA 
GTAGTTGAGG CTAAGACGTC TGAAGCCAGG CCCTTTAATG ATTCTACTCA TGCTGAGCCC 
TTGAATGATT CTACTCACAT TTCTTTGCAA GAAGAAAACC AGTCTTCTGT CAGTCATTGT 
GTCCCTGATG TTTCTACAAT TACTGAAGAA GGCTTATTTA GCCAAAAGAG TTTCCTTGTT 
TTGGGTTTTA GTAATGAAAA TGAATCTAAC ATCGCAAACA TCATAAAAGA AAATGCTGGG 
AAAATCATGT CCCTTCTGAG CAGAACTGTT GCGGATTATG CTGTGGTTCC TCTGCTGGGG 
TGTGAAGTGG AAGCCACTGT GGGAGAAGTT GTTACAAATA CATGGCTGGT TACTTGCATA 
GACTATCAGA CTTTGTTTGA TCCAAAGTCG AATCCTCTCT TCACACCAGT TCCAGTAATG 
ACAGGAATGA CTCCTTTAGA GGATTGTGTT ATTTCATTTA GCCAGTGTGC TGGAGCAGAA 
AAAGAGTCTT TAACATTCCT AGCAAACCTC CTTGGAGCAA GTGTTCAAGA ATACTTTGTT 
CGCAAATCCA ATGCAAAGAA AGGCATGTTT GCCAGTACTC ATCTTATACT GAAAGAACGT 
GGTGGCTCTA AATATGAAGC TGCAAAGAAG TGGAATTTAC CTGCCGTTAC TATAGCTTGG 
CTGTTGGAGA CTGCTAGAAC GGGAAAGAGA GCAGACGAAA GCCATTTTCT GATTGAAAAT 
TCAACTAAAG AAGAACGAAG TTTGGAAACA GAAATAACAA ATGGAATCAA TCTAAATTCA 
GATACTGCAG AGCATCCTGG CACACGCCTG CAAACTCACA GAAAAACCGT CGTTACACCT 
TTAGATATGA ACCGCTTTCA GAGTAAAGCT TTCCGTGCTG TGGTCTCACA ACATGCCAGA 
CAGGTCGCAG CCTCCCCAGC AGTAGGACAA CCACTTCAGA AGGAGCCCTC GTTACACCTG 
GATACACCAT CAAAATTCCT GTCCAAGGAC AAACTCTTCA AGCCTTCCTT TGATGTGAAG 
GATGCACTTG CAGCCTTGGA AACTCCAGGA CGTCCCAGCC AACAGAAAAG GAAACCGAGT 
ACGCCACTCT CAGAAGTTAT TGTCAAAAAC TTGCAACTTG CTTTGGCAAA TAGCTCTCGA 
AATGCTGTCG CTCTTTCTGC CAGCCCTCAA CTGAAAGAGG CCCAGTCAGA GAAGGAAGAA 
GCCCCAAAGC CACTTCACAA AGTAGTGGTA TGTGTTAGTA AAAAACTCAG TAAGAAGCAG 
AGTGAACTAA ATGGGATCGC AGCCTCTCTA GGAGCAGATT ACAGGTGGAG TTTTGATGAA 
ACAGTGACTC ATTTCATCTA TCAAGGGCGG CCAAATGACA CTAATCGGGA GTATAAATCT 
GTAAAAGAAA GAGGAGTACA CATTGTTTCC GAGCACTGGC TTTTAGATTG TGCCCAAGAG 
TGTAAACATC TTCCTGAATC TCTTTATCCA CATACTTATA ATCCCAAAAT GAGCTTGGAT 
ATCAGCGCAG TGCAAGATGG CCGGCTCTGT AATAGTCGAC TACTCTCAGC TGTGTCTTCA 
ACAAAGGATG ATGAGCCAGA TCCTTTGATT TTAGAAGAAA ATGATGTAGA CAATATGGCC 
ACCAATAATA AAGAGTCAGC ACCATCAAAT GGAAGTGGAA AGAATGACTC TAAAGGAGTT 
CTGACACAGA CCTTAGAGAT GAGAGAGAAC TTTCAGAAGC AGTTACAGGA GATAATGTCT 
GCAACATCAA TAGTGAAACC CCAAGGGCAG AGGACTTCCC TTTCAAGAAG TGGTTGTAAC 
AGCGCATCTT CAACCCCTGA CAGCACTCGC TCTGCTCGCA GTGGACGAAG TAGAGTCCTA 
GAGGCACTGA GGCAGTCTCG TCAGACAGTA CCTGATGTCA ACACAGAGCC TTCCCAAAAT 
GAACAGATCA TTTGGGATGA CCCTACAGCA AGGGAGGAGA GAGCAAGGCT TGCCAGCAAT 
TTGCAGTGGC CTAGTTGTCC CACACAATAC TCTGAGCTTC AGGTTGACAT TCAAAACTTG 
GAGGATTCTC CTTTTCAAAA GCCTTTACAT GATTCAGAAA TTGCTAAACA GGCTGTCTGT 
GATCCTGGAA ACATACGTGT GACTGAAGCT CCCAAACACC CAATCTCTGA AGAACTGGAA 
ACTCCCATAA AAGACAGCCA CCTGATCCCT ACGCCTCAAG CCCCCAGTAT TGCCTTTCCA 
CTCGCCAACC CCCCTGTGGC TCCGCACCCT AGAGAAAAGA TTATAACGAT AGAGGAGACT 
CATGAAGAAT TAAAAAAACA GTACATATTT CAGTTATCAT CTCTGAATCC TCAAGAACGT 
ATTGACTATT GTCATCTGAT TGAGAAACTA GGTGGATTGG TGATAGAAAA GCAGTGCTTT 
GATCCCACCT GTACACACAT TGTTGTGGGA CATCCACTTC GAAACGAGAA GTATTTAGCC 
TCAGTGGCAG CTGGGAAGTG GGTGCTTCAT CGCTCCTACC TTGAAGCCTG CAGGACTGCT 
GGACACTTCG TGCAGGAAGA AGACTATGAA TGGGGAAGTA GTTCCATACT TGATGTTCTG 
ACTGGAATCA ATGTACAGCA ACGAAGACTA GCACTTGCAG CAATGAGATG GAGAAAAAAA 
ATCCAGCAAA GACAAGAATC TGGCATTGTT GAGGGAGCAT TTAGTGGGTG GAAGGTTATT 
TTACATGTGG ATCAGTCTCG AGAAGCAGGC TTCAAACGCC TTCTTCAGTC AGGAGGAGCA 
AAGGTGCTAC CTGGTCATTC TGTACCTTTA TTTAAAGAGG CCACACATCT TTTTTCTGAC 
TTGAATAAAC TGAAACCAGA TGACTCAGGA GTTAATATAG CAGAAGCTGC TGCCCAGAAC 
GTGTACTGCT TGAGAACAGA ATACATTGCT GATTATCTCA TGCAGGAATC ACCTCCTCAT 
GTAGAAAATT ACTGTCTACC AGAAGCTATT TCATTTATTC AGAATAATAA GGAACTTGGG 
ACTGGATTAT CACAAAAGAG GAAAGCTCCT ACAGAAAAAA ATAAAATCAA ACGACCTAGA 
GTACACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016861125.1
CDS	203..4771
Translation	MSRNDKEPFFVKFLKSSDNSKCFFKALESIKEFQSEEYLQIITEEEALKIKENDRSLYICDPFSGVVFDHLKKLGCRIVGPQVVIFCMHHQRCVPRAEHPVYNMVMSDVTISCTSLEKEKREEVHKYVQMMGGRVYRDLNVSVTHLIAGEVGSKKYLVAANLKKPILLPSWIKTLWEKSQEKKITRYTDINMEDFKCPIFLGCIICVTGLCGLDRKEVQQLTVKHGGQYMGQLKMNECTHLIVQEPKGQKYECAKRWNVHCVTTQWFFDSIEKGFCQDESIYKTEPRPEAKTMPNSSTPTSQINTIDSRTLSDVSNISNINASCVSESICNSLNSKLEPTLENLENLDVSAFQAPEDLLDGCRIYLCGFSGRKLDKLRRLINSGGGVRFNQLNEDVTHVIVGDYDDELKQFWNKSAHRPHVVGAKWLLECFSKGYMLSEEPYIHANYQPVEIPVSHKPESKAALLKKKNSSFSKKDFAPSEKHEQADEDLLSQYENGSSTVVEAKTSEARPFNDSTHAEPLNDSTHISLQEENQSSVSHCVPDVSTITEEGLFSQKSFLVLGFSNENESNIANIIKENAGKIMSLLSRTVADYAVVPLLGCEVEATVGEVVTNTWLVTCIDYQTLFDPKSNPLFTPVPVMTGMTPLEDCVISFSQCAGAEKESLTFLANLLGASVQEYFVRKSNAKKGMFASTHLILKERGGSKYEAAKKWNLPAVTIAWLLETARTGKRADESHFLIENSTKEERSLETEITNGINLNSDTAEHPGTRLQTHRKTVVTPLDMNRFQSKAFRAVVSQHARQVAASPAVGQPLQKEPSLHLDTPSKFLSKDKLFKPSFDVKDALAALETPGRPSQQKRKPSTPLSEVIVKNLQLALANSSRNAVALSASPQLKEAQSEKEEAPKPLHKVVVCVSKKLSKKQSELNGIAASLGADYRWSFDETVTHFIYQGRPNDTNREYKSVKERGVHIVSEHWLLDCAQECKHLPESLYPHTYNPKMSLDISAVQDGRLCNSRLLSAVSSTKDDEPDPLILEENDVDNMATNNKESAPSNGSGKNDSKGVLTQTLEMRENFQKQLQEIMSATSIVKPQGQRTSLSRSGCNSASSTPDSTRSARSGRSRVLEALRQSRQTVPDVNTEPSQNEQIIWDDPTAREERARLASNLQWPSCPTQYSELQVDIQNLEDSPFQKPLHDSEIAKQAVCDPGNIRVTEAPKHPISEELETPIKDSHLIPTPQAPSIAFPLANPPVAPHPREKIITIEETHEELKKQYIFQLSSLNPQERIDYCHLIEKLGGLVIEKQCFDPTCTHIVVGHPLRNEKYLASVAAGKWVLHRSYLEACRTAGHFVQEEDYEWGSSSILDVLTGINVQQRRLALAAMRWRKKIQQRQESGIVEGAFSGWKVILHVDQSREAGFKRLLQSGGAKVLPGHSVPLFKEATHLFSDLNKLKPDDSGVNIAEAAAQNVYCLRTEYIADYLMQESPPHVENYCLPEAISFIQNNKELGTGLSQKRKAPTEKNKIKRPRVH

Target ORF information:

RefSeq Version	XM_017005636.1
Organism	Homo sapiens(human)
Definition	Homo sapiens topoisomerase (DNA) II binding protein 1 (TOPBP1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017005636.1

ORF Insert Sequence:

ATGTCCAGAA ATGACAAAGA ACCGTTTTTT GTGAAGTTTT TAAAGTCTTC AGACAATTCC 
AAATGTTTTT TTAAAGCTCT CGAGTCCATA AAAGAATTCC AATCAGAAGA ATATCTTCAG 
ATTATTACAG AAGAAGAGGC ATTGAAGATA AAGGAGAATG ATAGATCACT TTATATCTGT 
GACCCTTTTA GTGGCGTTGT CTTTGATCAC CTCAAAAAGC TTGGCTGCAG AATTGTTGGT 
CCTCAAGTAG TCATATTTTG TATGCACCAC CAGCGATGTG TCCCAAGAGC CGAACATCCA 
GTTTATAATA TGGTTATGTC TGATGTAACC ATATCTTGTA CAAGTCTGGA AAAAGAAAAA 
AGGGAAGAAG TTCATAAATA TGTACAAATG ATGGGCGGAC GAGTATACAG AGACCTTAAT 
GTATCAGTAA CTCACCTTAT TGCAGGAGAA GTTGGTAGCA AAAAATATTT AGTTGCTGCA 
AACCTGAAGA AACCTATTTT GCTTCCCTCT TGGATAAAAA CACTTTGGGA GAAGTCACAA 
GAGAAAAAAA TAACTAGATA TACTGATATA AACATGGAAG ATTTCAAGTG TCCTATTTTT 
CTTGGTTGCA TAATCTGTGT GACTGGCTTA TGTGGCTTAG ACAGGAAAGA AGTTCAGCAA 
CTCACAGTTA AGCATGGAGG TCAATACATG GGACAATTGA AAATGAATGA ATGTACACAC 
CTCATTGTGC AAGAACCAAA AGGTCAGAAG TATGAGTGTG CCAAGAGATG GAATGTACAC 
TGTGTGACCA CACAGTGGTT TTTTGACAGT ATTGAGAAAG GTTTTTGTCA GGATGAATCC 
ATATACAAGA CAGAACCTAG ACCAGAAGCA AAGACTATGC CCAATTCTTC AACTCCTACC 
AGCCAGATCA ACACAATTGA TAGTCGTACT CTTTCAGATG TCAGCAATAT TTCCAACATA 
AATGCAAGTT GCGTAAGTGA ATCAATATGT AATTCACTTA ACAGCAAACT GGAGCCTACA 
CTTGAAAATC TAGAAAATCT GGATGTCAGT GCATTTCAAG CACCTGAAGA TTTATTAGAT 
GGTTGTCGGA TATATCTTTG CGGTTTTAGT GGCAGAAAGC TAGATAAACT GAGAAGACTT 
ATTAACAGTG GAGGTGGAGT TCGTTTTAAC CAGCTAAATG AAGATGTAAC TCATGTTATT 
GTGGGAGATT ATGATGATGA ATTGAAGCAG TTTTGGAATA AATCAGCCCA CAGGCCTCAT 
GTAGTGGGAG CAAAGTGGTT GCTAGAGTGT TTCAGTAAAG GTTATATGCT TTCTGAAGAA 
CCATATATCC ATGCTAATTA CCAGCCAGTG GAAATTCCAG TTTCACATAA GCCTGAAAGT 
AAAGCAGCTC TTTTAAAAAA GAAGAACAGC AGCTTCTCTA AGAAAGACTT TGCTCCTAGT 
GAAAAGCATG AGCAAGCTGA TGAAGATCTG CTCTCTCAAT ATGAAAATGG TAGCTCCACA 
GTAGTTGAGG CTAAGACGTC TGAAGCCAGG CCCTTTAATG ATTCTACTCA TGCTGAGCCC 
TTGAATGATT CTACTCACAT TTCTTTGCAA GAAGAAAACC AGTCTTCTGT CAGTCATTGT 
GTCCCTGATG TTTCTACAAT TACTGAAGAA GGCTTATTTA GCCAAAAGAG TTTCCTTGTT 
TTGGGTTTTA GTAATGAAAA TGAATCTAAC ATCGCAAACA TCATAAAAGA AAATGCTGGG 
AAAATCATGT CCCTTCTGAG CAGAACTGTT GCGGATTATG CTGTGGTTCC TCTGCTGGGG 
TGTGAAGTGG AAGCCACTGT GGGAGAAGTT GTTACAAATA CATGGCTGGT TACTTGCATA 
GACTATCAGA CTTTGTTTGA TCCAAAGTCG AATCCTCTCT TCACACCAGT TCCAGTAATG 
ACAGGAATGA CTCCTTTAGA GGATTGTGTT ATTTCATTTA GCCAGTGTGC TGGAGCAGAA 
AAAGAGTCTT TAACATTCCT AGCAAACCTC CTTGGAGCAA GTGTTCAAGA ATACTTTGTT 
CGCAAATCCA ATGCAAAGAA AGGCATGTTT GCCAGTACTC ATCTTATACT GAAAGAACGT 
GGTGGCTCTA AATATGAAGC TGCAAAGAAG TGGAATTTAC CTGCCGTTAC TATAGCTTGG 
CTGTTGGAGA CTGCTAGAAC GGGAAAGAGA GCAGACGAAA GCCATTTTCT GATTGAAAAT 
TCAACTAAAG AAGAACGAAG TTTGGAAACA GAAATAACAA ATGGAATCAA TCTAAATTCA 
GATACTGCAG AGCATCCTGG CACACGCCTG CAAACTCACA GAAAAACCGT CGTTACACCT 
TTAGATATGA ACCGCTTTCA GAGTAAAGCT TTCCGTGCTG TGGTCTCACA ACATGCCAGA 
CAGGTCGCAG CCTCCCCAGC AGTAGGACAA CCACTTCAGA AGGAGCCCTC GTTACACCTG 
GATACACCAT CAAAATTCCT GTCCAAGGAC AAACTCTTCA AGCCTTCCTT TGATGTGAAG 
GATGCACTTG CAGCCTTGGA AACTCCAGGA CGTCCCAGCC AACAGAAAAG GAAACCGAGT 
ACGCCACTCT CAGAAGTTAT TGTCAAAAAC TTGCAACTTG CTTTGGCAAA TAGCTCTCGA 
AATGCTGTCG CTCTTTCTGC CAGCCCTCAA CTGAAAGAGG CCCAGTCAGA GAAGGAAGAA 
GCCCCAAAGC CACTTCACAA AGTAGTGGTA TGTGTTAGTA AAAAACTCAG TAAGAAGCAG 
AGTGAACTAA ATGGGATCGC AGCCTCTCTA GGAGCAGATT ACAGGTGGAG TTTTGATGAA 
ACAGTGACTC ATTTCATCTA TCAAGGGCGG CCAAATGACA CTAATCGGGA GTATAAATCT 
GTAAAAGAAA GAGGAGTACA CATTGTTTCC GAGCACTGGC TTTTAGATTG TGCCCAAGAG 
TGTAAACATC TTCCTGAATC TCTTTATCCA CATACTTATA ATCCCAAAAT GAGCTTGGAT 
ATCAGCGCAG TGCAAGATGG CCGGCTCTGT AATAGTCGAC TACTCTCAGC TGTGTCTTCA 
ACAAAGGATG ATGAGCCAGA TCCTTTGATT TTAGAAGAAA ATGATGTAGA CAATATGGCC 
ACCAATAATA AAGAGTCAGC ACCATCAAAT GGAAGTGGAA AGAATGACTC TAAAGGAGTT 
CTGACACAGA CCTTAGAGAT GAGAGAGAAC TTTCAGAAGC AGTTACAGGA GATAATGTCT 
GCAACATCAA TAGTGAAACC CCAAGGGCAG AGGACTTCCC TTTCAAGAAG TGGTTGTAAC 
AGCGCATCTT CAACCCCTGA CAGCACTCGC TCTGCTCGCA GTGGACGAAG TAGAGTCCTA 
GAGGCACTGA GGCAGTCTCG TCAGACAGTA CCTGATGTCA ACACAGAGCC TTCCCAAAAT 
GAACAGATCA TTTGGGATGA CCCTACAGCA AGGGAGGAGA GAGCAAGGCT TGCCAGCAAT 
TTGCAGTGGC CTAGTTGTCC CACACAATAC TCTGAGCTTC AGGTTGACAT TCAAAACTTG 
GAGGATTCTC CTTTTCAAAA GCCTTTACAT GATTCAGAAA TTGCTAAACA GGCTGTCTGT 
GATCCTGGAA ACATACGTGT GACTGAAGCT CCCAAACACC CAATCTCTGA AGAACTGGAA 
ACTCCCATAA AAGACAGCCA CCTGATCCCT ACGCCTCAAG CCCCCAGTAT TGCCTTTCCA 
CTCGCCAACC CCCCTGTGGC TCCGCACCCT AGAGAAAAGA TTATAACGAT AGAGGAGACT 
CATGAAGAAT TAAAAAAACA GTACATATTT CAGTTATCAT CTCTGAATCC TCAAGAACGT 
ATTGACTATT GTCATCTGAT TGAGAAACTA GGTGGATTGG TGATAGAAAA GCAGTGCTTT 
GATCCCACCT GTACACACAT TGTTGTGGGA CATCCACTTC GAAACGAGAA GTATTTAGCC 
TCAGTGGCAG CTGGGAAGTG GGTGCTTCAT CGCTCCTACC TTGAAGCCTG CAGGACTGCT 
GGACACTTCG TGCAGGAAGA AGACTATGAA TGGGGAAGTA GTTCCATACT TGATGTTCTG 
ACTGGAATCA ATGTACAGCA ACGAAGACTA GCACTTGCAG CAATGAGATG GAGAAAAAAA 
ATCCAGCAAA GACAAGAATC TGGCATTGTT GAGGGAGCAT TTAGTGGGTG GAAGGTTATT 
TTACATGTGG ATCAGTCTCG AGAAGCAGGC TTCAAACGCC TTCTTCAGTC AGGAGGAGCA 
AAGGTGCTAC CTGGTCATTC TGTACCTTTA TTTAAAGAGG CCACACATCT TTTTTCTGAC 
TTGAATAAAC TGAAACCAGA TGACTCAGGA GTTAATATAG CAGAAGCTGC TGCCCAGAAC 
GTGTACTGCT TGAGAACAGA ATACATTGCT GATTATCTCA TGCAGGAATC ACCTCCTCAT 
GTAGAAAATT ACTGTCTACC AGAAGCTATT TCATTTATTC AGAATAATAA GGAACTTGGG 
ACTGGATTAT CACAAAAGAG GAAAGCTCCT ACAGAAAAAA ATAAAATCAA ACGACCTAGA 
GTACACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TOPBP1 ( XM_017005636.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_016861125.1 Homo sapiens DNA topoisomerase II binding protein 1 (TOPBP1), transcript variant X1, mRNA.

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CloneID	OHu16438
Clone ID Related Accession (Same CDS sequence)	XM_017005636.1 , XM_017005636.2 , NM_007027.3 , NM_007027.4
Accession Version	XM_017005636.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 4569bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	DNA topoisomerase 2-binding protein 1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000003.12) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_017005636.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTCCAGAA ATGACAAAGA ACCGTTTTTT GTGAAGTTTT TAAAGTCTTC AGACAATTCC 
AAATGTTTTT TTAAAGCTCT CGAGTCCATA AAAGAATTCC AATCAGAAGA ATATCTTCAG 
ATTATTACAG AAGAAGAGGC ATTGAAGATA AAGGAGAATG ATAGATCACT TTATATCTGT 
GACCCTTTTA GTGGCGTTGT CTTTGATCAC CTCAAAAAGC TTGGCTGCAG AATTGTTGGT 
CCTCAAGTAG TCATATTTTG TATGCACCAC CAGCGATGTG TCCCAAGAGC CGAACATCCA 
GTTTATAATA TGGTTATGTC TGATGTAACC ATATCTTGTA CAAGTCTGGA AAAAGAAAAA 
AGGGAAGAAG TTCATAAATA TGTACAAATG ATGGGCGGAC GAGTATACAG AGACCTTAAT 
GTATCAGTAA CTCACCTTAT TGCAGGAGAA GTTGGTAGCA AAAAATATTT AGTTGCTGCA 
AACCTGAAGA AACCTATTTT GCTTCCCTCT TGGATAAAAA CACTTTGGGA GAAGTCACAA 
GAGAAAAAAA TAACTAGATA TACTGATATA AACATGGAAG ATTTCAAGTG TCCTATTTTT 
CTTGGTTGCA TAATCTGTGT GACTGGCTTA TGTGGCTTAG ACAGGAAAGA AGTTCAGCAA 
CTCACAGTTA AGCATGGAGG TCAATACATG GGACAATTGA AAATGAATGA ATGTACACAC 
CTCATTGTGC AAGAACCAAA AGGTCAGAAG TATGAGTGTG CCAAGAGATG GAATGTACAC 
TGTGTGACCA CACAGTGGTT TTTTGACAGT ATTGAGAAAG GTTTTTGTCA GGATGAATCC 
ATATACAAGA CAGAACCTAG ACCAGAAGCA AAGACTATGC CCAATTCTTC AACTCCTACC 
AGCCAGATCA ACACAATTGA TAGTCGTACT CTTTCAGATG TCAGCAATAT TTCCAACATA 
AATGCAAGTT GCGTAAGTGA ATCAATATGT AATTCACTTA ACAGCAAACT GGAGCCTACA 
CTTGAAAATC TAGAAAATCT GGATGTCAGT GCATTTCAAG CACCTGAAGA TTTATTAGAT 
GGTTGTCGGA TATATCTTTG CGGTTTTAGT GGCAGAAAGC TAGATAAACT GAGAAGACTT 
ATTAACAGTG GAGGTGGAGT TCGTTTTAAC CAGCTAAATG AAGATGTAAC TCATGTTATT 
GTGGGAGATT ATGATGATGA ATTGAAGCAG TTTTGGAATA AATCAGCCCA CAGGCCTCAT 
GTAGTGGGAG CAAAGTGGTT GCTAGAGTGT TTCAGTAAAG GTTATATGCT TTCTGAAGAA 
CCATATATCC ATGCTAATTA CCAGCCAGTG GAAATTCCAG TTTCACATAA GCCTGAAAGT 
AAAGCAGCTC TTTTAAAAAA GAAGAACAGC AGCTTCTCTA AGAAAGACTT TGCTCCTAGT 
GAAAAGCATG AGCAAGCTGA TGAAGATCTG CTCTCTCAAT ATGAAAATGG TAGCTCCACA 
GTAGTTGAGG CTAAGACGTC TGAAGCCAGG CCCTTTAATG ATTCTACTCA TGCTGAGCCC 
TTGAATGATT CTACTCACAT TTCTTTGCAA GAAGAAAACC AGTCTTCTGT CAGTCATTGT 
GTCCCTGATG TTTCTACAAT TACTGAAGAA GGCTTATTTA GCCAAAAGAG TTTCCTTGTT 
TTGGGTTTTA GTAATGAAAA TGAATCTAAC ATCGCAAACA TCATAAAAGA AAATGCTGGG 
AAAATCATGT CCCTTCTGAG CAGAACTGTT GCGGATTATG CTGTGGTTCC TCTGCTGGGG 
TGTGAAGTGG AAGCCACTGT GGGAGAAGTT GTTACAAATA CATGGCTGGT TACTTGCATA 
GACTATCAGA CTTTGTTTGA TCCAAAGTCG AATCCTCTCT TCACACCAGT TCCAGTAATG 
ACAGGAATGA CTCCTTTAGA GGATTGTGTT ATTTCATTTA GCCAGTGTGC TGGAGCAGAA 
AAAGAGTCTT TAACATTCCT AGCAAACCTC CTTGGAGCAA GTGTTCAAGA ATACTTTGTT 
CGCAAATCCA ATGCAAAGAA AGGCATGTTT GCCAGTACTC ATCTTATACT GAAAGAACGT 
GGTGGCTCTA AATATGAAGC TGCAAAGAAG TGGAATTTAC CTGCCGTTAC TATAGCTTGG 
CTGTTGGAGA CTGCTAGAAC GGGAAAGAGA GCAGACGAAA GCCATTTTCT GATTGAAAAT 
TCAACTAAAG AAGAACGAAG TTTGGAAACA GAAATAACAA ATGGAATCAA TCTAAATTCA 
GATACTGCAG AGCATCCTGG CACACGCCTG CAAACTCACA GAAAAACCGT CGTTACACCT 
TTAGATATGA ACCGCTTTCA GAGTAAAGCT TTCCGTGCTG TGGTCTCACA ACATGCCAGA 
CAGGTCGCAG CCTCCCCAGC AGTAGGACAA CCACTTCAGA AGGAGCCCTC GTTACACCTG 
GATACACCAT CAAAATTCCT GTCCAAGGAC AAACTCTTCA AGCCTTCCTT TGATGTGAAG 
GATGCACTTG CAGCCTTGGA AACTCCAGGA CGTCCCAGCC AACAGAAAAG GAAACCGAGT 
ACGCCACTCT CAGAAGTTAT TGTCAAAAAC TTGCAACTTG CTTTGGCAAA TAGCTCTCGA 
AATGCTGTCG CTCTTTCTGC CAGCCCTCAA CTGAAAGAGG CCCAGTCAGA GAAGGAAGAA 
GCCCCAAAGC CACTTCACAA AGTAGTGGTA TGTGTTAGTA AAAAACTCAG TAAGAAGCAG 
AGTGAACTAA ATGGGATCGC AGCCTCTCTA GGAGCAGATT ACAGGTGGAG TTTTGATGAA 
ACAGTGACTC ATTTCATCTA TCAAGGGCGG CCAAATGACA CTAATCGGGA GTATAAATCT 
GTAAAAGAAA GAGGAGTACA CATTGTTTCC GAGCACTGGC TTTTAGATTG TGCCCAAGAG 
TGTAAACATC TTCCTGAATC TCTTTATCCA CATACTTATA ATCCCAAAAT GAGCTTGGAT 
ATCAGCGCAG TGCAAGATGG CCGGCTCTGT AATAGTCGAC TACTCTCAGC TGTGTCTTCA 
ACAAAGGATG ATGAGCCAGA TCCTTTGATT TTAGAAGAAA ATGATGTAGA CAATATGGCC 
ACCAATAATA AAGAGTCAGC ACCATCAAAT GGAAGTGGAA AGAATGACTC TAAAGGAGTT 
CTGACACAGA CCTTAGAGAT GAGAGAGAAC TTTCAGAAGC AGTTACAGGA GATAATGTCT 
GCAACATCAA TAGTGAAACC CCAAGGGCAG AGGACTTCCC TTTCAAGAAG TGGTTGTAAC 
AGCGCATCTT CAACCCCTGA CAGCACTCGC TCTGCTCGCA GTGGACGAAG TAGAGTCCTA 
GAGGCACTGA GGCAGTCTCG TCAGACAGTA CCTGATGTCA ACACAGAGCC TTCCCAAAAT 
GAACAGATCA TTTGGGATGA CCCTACAGCA AGGGAGGAGA GAGCAAGGCT TGCCAGCAAT 
TTGCAGTGGC CTAGTTGTCC CACACAATAC TCTGAGCTTC AGGTTGACAT TCAAAACTTG 
GAGGATTCTC CTTTTCAAAA GCCTTTACAT GATTCAGAAA TTGCTAAACA GGCTGTCTGT 
GATCCTGGAA ACATACGTGT GACTGAAGCT CCCAAACACC CAATCTCTGA AGAACTGGAA 
ACTCCCATAA AAGACAGCCA CCTGATCCCT ACGCCTCAAG CCCCCAGTAT TGCCTTTCCA 
CTCGCCAACC CCCCTGTGGC TCCGCACCCT AGAGAAAAGA TTATAACGAT AGAGGAGACT 
CATGAAGAAT TAAAAAAACA GTACATATTT CAGTTATCAT CTCTGAATCC TCAAGAACGT 
ATTGACTATT GTCATCTGAT TGAGAAACTA GGTGGATTGG TGATAGAAAA GCAGTGCTTT 
GATCCCACCT GTACACACAT TGTTGTGGGA CATCCACTTC GAAACGAGAA GTATTTAGCC 
TCAGTGGCAG CTGGGAAGTG GGTGCTTCAT CGCTCCTACC TTGAAGCCTG CAGGACTGCT 
GGACACTTCG TGCAGGAAGA AGACTATGAA TGGGGAAGTA GTTCCATACT TGATGTTCTG 
ACTGGAATCA ATGTACAGCA ACGAAGACTA GCACTTGCAG CAATGAGATG GAGAAAAAAA 
ATCCAGCAAA GACAAGAATC TGGCATTGTT GAGGGAGCAT TTAGTGGGTG GAAGGTTATT 
TTACATGTGG ATCAGTCTCG AGAAGCAGGC TTCAAACGCC TTCTTCAGTC AGGAGGAGCA 
AAGGTGCTAC CTGGTCATTC TGTACCTTTA TTTAAAGAGG CCACACATCT TTTTTCTGAC 
TTGAATAAAC TGAAACCAGA TGACTCAGGA GTTAATATAG CAGAAGCTGC TGCCCAGAAC 
GTGTACTGCT TGAGAACAGA ATACATTGCT GATTATCTCA TGCAGGAATC ACCTCCTCAT 
GTAGAAAATT ACTGTCTACC AGAAGCTATT TCATTTATTC AGAATAATAA GGAACTTGGG 
ACTGGATTAT CACAAAAGAG GAAAGCTCCT ACAGAAAAAA ATAAAATCAA ACGACCTAGA 
GTACACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016861125.1
CDS	203..4771
Translation	MSRNDKEPFFVKFLKSSDNSKCFFKALESIKEFQSEEYLQIITEEEALKIKENDRSLYICDPFSGVVFDHLKKLGCRIVGPQVVIFCMHHQRCVPRAEHPVYNMVMSDVTISCTSLEKEKREEVHKYVQMMGGRVYRDLNVSVTHLIAGEVGSKKYLVAANLKKPILLPSWIKTLWEKSQEKKITRYTDINMEDFKCPIFLGCIICVTGLCGLDRKEVQQLTVKHGGQYMGQLKMNECTHLIVQEPKGQKYECAKRWNVHCVTTQWFFDSIEKGFCQDESIYKTEPRPEAKTMPNSSTPTSQINTIDSRTLSDVSNISNINASCVSESICNSLNSKLEPTLENLENLDVSAFQAPEDLLDGCRIYLCGFSGRKLDKLRRLINSGGGVRFNQLNEDVTHVIVGDYDDELKQFWNKSAHRPHVVGAKWLLECFSKGYMLSEEPYIHANYQPVEIPVSHKPESKAALLKKKNSSFSKKDFAPSEKHEQADEDLLSQYENGSSTVVEAKTSEARPFNDSTHAEPLNDSTHISLQEENQSSVSHCVPDVSTITEEGLFSQKSFLVLGFSNENESNIANIIKENAGKIMSLLSRTVADYAVVPLLGCEVEATVGEVVTNTWLVTCIDYQTLFDPKSNPLFTPVPVMTGMTPLEDCVISFSQCAGAEKESLTFLANLLGASVQEYFVRKSNAKKGMFASTHLILKERGGSKYEAAKKWNLPAVTIAWLLETARTGKRADESHFLIENSTKEERSLETEITNGINLNSDTAEHPGTRLQTHRKTVVTPLDMNRFQSKAFRAVVSQHARQVAASPAVGQPLQKEPSLHLDTPSKFLSKDKLFKPSFDVKDALAALETPGRPSQQKRKPSTPLSEVIVKNLQLALANSSRNAVALSASPQLKEAQSEKEEAPKPLHKVVVCVSKKLSKKQSELNGIAASLGADYRWSFDETVTHFIYQGRPNDTNREYKSVKERGVHIVSEHWLLDCAQECKHLPESLYPHTYNPKMSLDISAVQDGRLCNSRLLSAVSSTKDDEPDPLILEENDVDNMATNNKESAPSNGSGKNDSKGVLTQTLEMRENFQKQLQEIMSATSIVKPQGQRTSLSRSGCNSASSTPDSTRSARSGRSRVLEALRQSRQTVPDVNTEPSQNEQIIWDDPTAREERARLASNLQWPSCPTQYSELQVDIQNLEDSPFQKPLHDSEIAKQAVCDPGNIRVTEAPKHPISEELETPIKDSHLIPTPQAPSIAFPLANPPVAPHPREKIITIEETHEELKKQYIFQLSSLNPQERIDYCHLIEKLGGLVIEKQCFDPTCTHIVVGHPLRNEKYLASVAAGKWVLHRSYLEACRTAGHFVQEEDYEWGSSSILDVLTGINVQQRRLALAAMRWRKKIQQRQESGIVEGAFSGWKVILHVDQSREAGFKRLLQSGGAKVLPGHSVPLFKEATHLFSDLNKLKPDDSGVNIAEAAAQNVYCLRTEYIADYLMQESPPHVENYCLPEAISFIQNNKELGTGLSQKRKAPTEKNKIKRPRVH

Target ORF information:

RefSeq Version	XM_017005636.2
Organism	Homo sapiens(human)
Definition	Homo sapiens DNA topoisomerase II binding protein 1 (TOPBP1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017005636.2

ORF Insert Sequence:

ATGTCCAGAA ATGACAAAGA ACCGTTTTTT GTGAAGTTTT TAAAGTCTTC AGACAATTCC 
AAATGTTTTT TTAAAGCTCT CGAGTCCATA AAAGAATTCC AATCAGAAGA ATATCTTCAG 
ATTATTACAG AAGAAGAGGC ATTGAAGATA AAGGAGAATG ATAGATCACT TTATATCTGT 
GACCCTTTTA GTGGCGTTGT CTTTGATCAC CTCAAAAAGC TTGGCTGCAG AATTGTTGGT 
CCTCAAGTAG TCATATTTTG TATGCACCAC CAGCGATGTG TCCCAAGAGC CGAACATCCA 
GTTTATAATA TGGTTATGTC TGATGTAACC ATATCTTGTA CAAGTCTGGA AAAAGAAAAA 
AGGGAAGAAG TTCATAAATA TGTACAAATG ATGGGCGGAC GAGTATACAG AGACCTTAAT 
GTATCAGTAA CTCACCTTAT TGCAGGAGAA GTTGGTAGCA AAAAATATTT AGTTGCTGCA 
AACCTGAAGA AACCTATTTT GCTTCCCTCT TGGATAAAAA CACTTTGGGA GAAGTCACAA 
GAGAAAAAAA TAACTAGATA TACTGATATA AACATGGAAG ATTTCAAGTG TCCTATTTTT 
CTTGGTTGCA TAATCTGTGT GACTGGCTTA TGTGGCTTAG ACAGGAAAGA AGTTCAGCAA 
CTCACAGTTA AGCATGGAGG TCAATACATG GGACAATTGA AAATGAATGA ATGTACACAC 
CTCATTGTGC AAGAACCAAA AGGTCAGAAG TATGAGTGTG CCAAGAGATG GAATGTACAC 
TGTGTGACCA CACAGTGGTT TTTTGACAGT ATTGAGAAAG GTTTTTGTCA GGATGAATCC 
ATATACAAGA CAGAACCTAG ACCAGAAGCA AAGACTATGC CCAATTCTTC AACTCCTACC 
AGCCAGATCA ACACAATTGA TAGTCGTACT CTTTCAGATG TCAGCAATAT TTCCAACATA 
AATGCAAGTT GCGTAAGTGA ATCAATATGT AATTCACTTA ACAGCAAACT GGAGCCTACA 
CTTGAAAATC TAGAAAATCT GGATGTCAGT GCATTTCAAG CACCTGAAGA TTTATTAGAT 
GGTTGTCGGA TATATCTTTG CGGTTTTAGT GGCAGAAAGC TAGATAAACT GAGAAGACTT 
ATTAACAGTG GAGGTGGAGT TCGTTTTAAC CAGCTAAATG AAGATGTAAC TCATGTTATT 
GTGGGAGATT ATGATGATGA ATTGAAGCAG TTTTGGAATA AATCAGCCCA CAGGCCTCAT 
GTAGTGGGAG CAAAGTGGTT GCTAGAGTGT TTCAGTAAAG GTTATATGCT TTCTGAAGAA 
CCATATATCC ATGCTAATTA CCAGCCAGTG GAAATTCCAG TTTCACATAA GCCTGAAAGT 
AAAGCAGCTC TTTTAAAAAA GAAGAACAGC AGCTTCTCTA AGAAAGACTT TGCTCCTAGT 
GAAAAGCATG AGCAAGCTGA TGAAGATCTG CTCTCTCAAT ATGAAAATGG TAGCTCCACA 
GTAGTTGAGG CTAAGACGTC TGAAGCCAGG CCCTTTAATG ATTCTACTCA TGCTGAGCCC 
TTGAATGATT CTACTCACAT TTCTTTGCAA GAAGAAAACC AGTCTTCTGT CAGTCATTGT 
GTCCCTGATG TTTCTACAAT TACTGAAGAA GGCTTATTTA GCCAAAAGAG TTTCCTTGTT 
TTGGGTTTTA GTAATGAAAA TGAATCTAAC ATCGCAAACA TCATAAAAGA AAATGCTGGG 
AAAATCATGT CCCTTCTGAG CAGAACTGTT GCGGATTATG CTGTGGTTCC TCTGCTGGGG 
TGTGAAGTGG AAGCCACTGT GGGAGAAGTT GTTACAAATA CATGGCTGGT TACTTGCATA 
GACTATCAGA CTTTGTTTGA TCCAAAGTCG AATCCTCTCT TCACACCAGT TCCAGTAATG 
ACAGGAATGA CTCCTTTAGA GGATTGTGTT ATTTCATTTA GCCAGTGTGC TGGAGCAGAA 
AAAGAGTCTT TAACATTCCT AGCAAACCTC CTTGGAGCAA GTGTTCAAGA ATACTTTGTT 
CGCAAATCCA ATGCAAAGAA AGGCATGTTT GCCAGTACTC ATCTTATACT GAAAGAACGT 
GGTGGCTCTA AATATGAAGC TGCAAAGAAG TGGAATTTAC CTGCCGTTAC TATAGCTTGG 
CTGTTGGAGA CTGCTAGAAC GGGAAAGAGA GCAGACGAAA GCCATTTTCT GATTGAAAAT 
TCAACTAAAG AAGAACGAAG TTTGGAAACA GAAATAACAA ATGGAATCAA TCTAAATTCA 
GATACTGCAG AGCATCCTGG CACACGCCTG CAAACTCACA GAAAAACCGT CGTTACACCT 
TTAGATATGA ACCGCTTTCA GAGTAAAGCT TTCCGTGCTG TGGTCTCACA ACATGCCAGA 
CAGGTCGCAG CCTCCCCAGC AGTAGGACAA CCACTTCAGA AGGAGCCCTC GTTACACCTG 
GATACACCAT CAAAATTCCT GTCCAAGGAC AAACTCTTCA AGCCTTCCTT TGATGTGAAG 
GATGCACTTG CAGCCTTGGA AACTCCAGGA CGTCCCAGCC AACAGAAAAG GAAACCGAGT 
ACGCCACTCT CAGAAGTTAT TGTCAAAAAC TTGCAACTTG CTTTGGCAAA TAGCTCTCGA 
AATGCTGTCG CTCTTTCTGC CAGCCCTCAA CTGAAAGAGG CCCAGTCAGA GAAGGAAGAA 
GCCCCAAAGC CACTTCACAA AGTAGTGGTA TGTGTTAGTA AAAAACTCAG TAAGAAGCAG 
AGTGAACTAA ATGGGATCGC AGCCTCTCTA GGAGCAGATT ACAGGTGGAG TTTTGATGAA 
ACAGTGACTC ATTTCATCTA TCAAGGGCGG CCAAATGACA CTAATCGGGA GTATAAATCT 
GTAAAAGAAA GAGGAGTACA CATTGTTTCC GAGCACTGGC TTTTAGATTG TGCCCAAGAG 
TGTAAACATC TTCCTGAATC TCTTTATCCA CATACTTATA ATCCCAAAAT GAGCTTGGAT 
ATCAGCGCAG TGCAAGATGG CCGGCTCTGT AATAGTCGAC TACTCTCAGC TGTGTCTTCA 
ACAAAGGATG ATGAGCCAGA TCCTTTGATT TTAGAAGAAA ATGATGTAGA CAATATGGCC 
ACCAATAATA AAGAGTCAGC ACCATCAAAT GGAAGTGGAA AGAATGACTC TAAAGGAGTT 
CTGACACAGA CCTTAGAGAT GAGAGAGAAC TTTCAGAAGC AGTTACAGGA GATAATGTCT 
GCAACATCAA TAGTGAAACC CCAAGGGCAG AGGACTTCCC TTTCAAGAAG TGGTTGTAAC 
AGCGCATCTT CAACCCCTGA CAGCACTCGC TCTGCTCGCA GTGGACGAAG TAGAGTCCTA 
GAGGCACTGA GGCAGTCTCG TCAGACAGTA CCTGATGTCA ACACAGAGCC TTCCCAAAAT 
GAACAGATCA TTTGGGATGA CCCTACAGCA AGGGAGGAGA GAGCAAGGCT TGCCAGCAAT 
TTGCAGTGGC CTAGTTGTCC CACACAATAC TCTGAGCTTC AGGTTGACAT TCAAAACTTG 
GAGGATTCTC CTTTTCAAAA GCCTTTACAT GATTCAGAAA TTGCTAAACA GGCTGTCTGT 
GATCCTGGAA ACATACGTGT GACTGAAGCT CCCAAACACC CAATCTCTGA AGAACTGGAA 
ACTCCCATAA AAGACAGCCA CCTGATCCCT ACGCCTCAAG CCCCCAGTAT TGCCTTTCCA 
CTCGCCAACC CCCCTGTGGC TCCGCACCCT AGAGAAAAGA TTATAACGAT AGAGGAGACT 
CATGAAGAAT TAAAAAAACA GTACATATTT CAGTTATCAT CTCTGAATCC TCAAGAACGT 
ATTGACTATT GTCATCTGAT TGAGAAACTA GGTGGATTGG TGATAGAAAA GCAGTGCTTT 
GATCCCACCT GTACACACAT TGTTGTGGGA CATCCACTTC GAAACGAGAA GTATTTAGCC 
TCAGTGGCAG CTGGGAAGTG GGTGCTTCAT CGCTCCTACC TTGAAGCCTG CAGGACTGCT 
GGACACTTCG TGCAGGAAGA AGACTATGAA TGGGGAAGTA GTTCCATACT TGATGTTCTG 
ACTGGAATCA ATGTACAGCA ACGAAGACTA GCACTTGCAG CAATGAGATG GAGAAAAAAA 
ATCCAGCAAA GACAAGAATC TGGCATTGTT GAGGGAGCAT TTAGTGGGTG GAAGGTTATT 
TTACATGTGG ATCAGTCTCG AGAAGCAGGC TTCAAACGCC TTCTTCAGTC AGGAGGAGCA 
AAGGTGCTAC CTGGTCATTC TGTACCTTTA TTTAAAGAGG CCACACATCT TTTTTCTGAC 
TTGAATAAAC TGAAACCAGA TGACTCAGGA GTTAATATAG CAGAAGCTGC TGCCCAGAAC 
GTGTACTGCT TGAGAACAGA ATACATTGCT GATTATCTCA TGCAGGAATC ACCTCCTCAT 
GTAGAAAATT ACTGTCTACC AGAAGCTATT TCATTTATTC AGAATAATAA GGAACTTGGG 
ACTGGATTAT CACAAAAGAG GAAAGCTCCT ACAGAAAAAA ATAAAATCAA ACGACCTAGA 
GTACACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TOPBP1 ( XM_017005637.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016861126.1 Homo sapiens topoisomerase (DNA) II binding protein 1 (TOPBP1), transcript variant X5, mRNA.

Price & Availability↑

CloneID	OHu93765
Clone ID Related Accession (Same CDS sequence)	XM_017005637.1 , XM_017005637.2
Accession Version	XM_017005637.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3264bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-05
Organism	Homo sapiens(human)
Product	DNA topoisomerase 2-binding protein 1 isoform X4
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000003.12) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCTTTCTG AAGAACCATA TATCCATGCT AATTACCAGC CAGTGGAAAT TCCAGTTTCA 
CATAAGCCTG AAAGTAAAGC AGCTCTTTTA AAAAAGAAGA ACAGCAGCTT CTCTAAGAAA 
GACTTTGCTC CTAGTGAAAA GCATGAGCAA GCTGATGAAG ATCTGCTCTC TCAATATGAA 
AATGGTAGCT CCACAGTAGT TGAGGCTAAG ACGTCTGAAG CCAGGCCCTT TAATGATTCT 
ACTCATGCTG AGCCCTTGAA TGATTCTACT CACATTTCTT TGCAAGAAGA AAACCAGTCT 
TCTGTCAGTC ATTGTGTCCC TGATGTTTCT ACAATTACTG AAGAAGGCTT ATTTAGCCAA 
AAGAGTTTCC TTGTTTTGGG TTTTAGTAAT GAAAATGAAT CTAACATCGC AAACATCATA 
AAAGAAAATG CTGGGAAAAT CATGTCCCTT CTGAGCAGAA CTGTTGCGGA TTATGCTGTG 
GTTCCTCTGC TGGGGTGTGA AGTGGAAGCC ACTGTGGGAG AAGTTGTTAC AAATACATGG 
CTGGTTACTT GCATAGACTA TCAGACTTTG TTTGATCCAA AGTCGAATCC TCTCTTCACA 
CCAGTTCCAG TAATGACAGG AATGACTCCT TTAGAGGATT GTGTTATTTC ATTTAGCCAG 
TGTGCTGGAG CAGAAAAAGA GTCTTTAACA TTCCTAGCAA ACCTCCTTGG AGCAAGTGTT 
CAAGAATACT TTGTTCGCAA ATCCAATGCA AAGAAAGGCA TGTTTGCCAG TACTCATCTT 
ATACTGAAAG AACGTGGTGG CTCTAAATAT GAAGCTGCAA AGAAGTGGAA TTTACCTGCC 
GTTACTATAG CTTGGCTGTT GGAGACTGCT AGAACGGGAA AGAGAGCAGA CGAAAGCCAT 
TTTCTGATTG AAAATTCAAC TAAAGAAGAA CGAAGTTTGG AAACAGAAAT AACAAATGGA 
ATCAATCTAA ATTCAGATAC TGCAGAGCAT CCTGGCACAC GCCTGCAAAC TCACAGAAAA 
ACCGTCGTTA CACCTTTAGA TATGAACCGC TTTCAGAGTA AAGCTTTCCG TGCTGTGGTC 
TCACAACATG CCAGACAGGT CGCAGCCTCC CCAGCAGTAG GACAACCACT TCAGAAGGAG 
CCCTCGTTAC ACCTGGATAC ACCATCAAAA TTCCTGTCCA AGGACAAACT CTTCAAGCCT 
TCCTTTGATG TGAAGGATGC ACTTGCAGCC TTGGAAACTC CAGGACGTCC CAGCCAACAG 
AAAAGGAAAC CGAGTACGCC ACTCTCAGAA GTTATTGTCA AAAACTTGCA ACTTGCTTTG 
GCAAATAGCT CTCGAAATGC TGTCGCTCTT TCTGCCAGCC CTCAACTGAA AGAGGCCCAG 
TCAGAGAAGG AAGAAGCCCC AAAGCCACTT CACAAAGTAG TGGTATGTGT TAGTAAAAAA 
CTCAGTAAGA AGCAGAGTGA ACTAAATGGG ATCGCAGCCT CTCTAGGAGC AGATTACAGG 
TGGAGTTTTG ATGAAACAGT GACTCATTTC ATCTATCAAG GGCGGCCAAA TGACACTAAT 
CGGGAGTATA AATCTGTAAA AGAAAGAGGA GTACACATTG TTTCCGAGCA CTGGCTTTTA 
GATTGTGCCC AAGAGTGTAA ACATCTTCCT GAATCTCTTT ATCCACATAC TTATAATCCC 
AAAATGAGCT TGGATATCAG CGCAGTGCAA GATGGCCGGC TCTGTAATAG TCGACTACTC 
TCAGCTGTGT CTTCAACAAA GGATGATGAG CCAGATCCTT TGATTTTAGA AGAAAATGAT 
GTAGACAATA TGGCCACCAA TAATAAAGAG TCAGCACCAT CAAATGGAAG TGGAAAGAAT 
GACTCTAAAG GAGTTCTGAC ACAGACCTTA GAGATGAGAG AGAACTTTCA GAAGCAGTTA 
CAGGAGATAA TGTCTGCAAC ATCAATAGTG AAACCCCAAG GGCAGAGGAC TTCCCTTTCA 
AGAAGTGGTT GTAACAGCGC ATCTTCAACC CCTGACAGCA CTCGCTCTGC TCGCAGTGGA 
CGAAGTAGAG TCCTAGAGGC ACTGAGGCAG TCTCGTCAGA CAGTACCTGA TGTCAACACA 
GAGCCTTCCC AAAATGAACA GATCATTTGG GATGACCCTA CAGCAAGGGA GGAGAGAGCA 
AGGCTTGCCA GCAATTTGCA GTGGCCTAGT TGTCCCACAC AATACTCTGA GCTTCAGGTT 
GACATTCAAA ACTTGGAGGA TTCTCCTTTT CAAAAGCCTT TACATGATTC AGAAATTGCT 
AAACAGGCTG TCTGTGATCC TGGAAACATA CGTGTGACTG AAGCTCCCAA ACACCCAATC 
TCTGAAGAAC TGGAAACTCC CATAAAAGAC AGCCACCTGA TCCCTACGCC TCAAGCCCCC 
AGTATTGCCT TTCCACTCGC CAACCCCCCT GTGGCTCCGC ACCCTAGAGA AAAGATTATA 
ACGATAGAGG AGACTCATGA AGAATTAAAA AAACAGTACA TATTTCAGTT ATCATCTCTG 
AATCCTCAAG AACGTATTGA CTATTGTCAT CTGATTGAGA AACTAGGTGG ATTGGTGATA 
GAAAAGCAGT GCTTTGATCC CACCTGTACA CACATTGTTG TGGGACATCC ACTTCGAAAC 
GAGAAGTATT TAGCCTCAGT GGCAGCTGGG AAGTGGGTGC TTCATCGCTC CTACCTTGAA 
GCCTGCAGGA CTGCTGGACA CTTCGTGCAG GAAGAAGACT ATGAATGGGG AAGTAGTTCC 
ATACTTGATG TTCTGACTGG AATCAATGTA CAGCAACGAA GACTAGCACT TGCAGCAATG 
AGATGGAGAA AAAAAATCCA GCAAAGACAA GAATCTGGCA TTGTTGAGGG AGCATTTAGT 
GGGTGGAAGG TTATTTTACA TGTGGATCAG TCTCGAGAAG CAGGCTTCAA ACGCCTTCTT 
CAGTCAGGAG GAGCAAAGGT GCTACCTGGT CATTCTGTAC CTTTATTTAA AGAGGCCACA 
CATCTTTTTT CTGACTTGAA TAAACTGAAA CCAGATGACT CAGGAGTTAA TATAGCAGAA 
GCTGCTGCCC AGAACGTGTA CTGCTTGAGA ACAGAATACA TTGCTGATTA TCTCATGCAG 
GAATCACCTC CTCATGTAGA AAATTACTGT CTACCAGAAG CTATTTCATT TATTCAGAAT 
AATAAGGAAC TTGGGACTGG ATTATCACAA AAGAGGAAAG CTCCTACAGA AAAAAATAAA 
ATCAAACGAC CTAGAGTACA CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016861126.1
CDS	962..4225
Translation	MLSEEPYIHANYQPVEIPVSHKPESKAALLKKKNSSFSKKDFAPSEKHEQADEDLLSQYENGSSTVVEAKTSEARPFNDSTHAEPLNDSTHISLQEENQSSVSHCVPDVSTITEEGLFSQKSFLVLGFSNENESNIANIIKENAGKIMSLLSRTVADYAVVPLLGCEVEATVGEVVTNTWLVTCIDYQTLFDPKSNPLFTPVPVMTGMTPLEDCVISFSQCAGAEKESLTFLANLLGASVQEYFVRKSNAKKGMFASTHLILKERGGSKYEAAKKWNLPAVTIAWLLETARTGKRADESHFLIENSTKEERSLETEITNGINLNSDTAEHPGTRLQTHRKTVVTPLDMNRFQSKAFRAVVSQHARQVAASPAVGQPLQKEPSLHLDTPSKFLSKDKLFKPSFDVKDALAALETPGRPSQQKRKPSTPLSEVIVKNLQLALANSSRNAVALSASPQLKEAQSEKEEAPKPLHKVVVCVSKKLSKKQSELNGIAASLGADYRWSFDETVTHFIYQGRPNDTNREYKSVKERGVHIVSEHWLLDCAQECKHLPESLYPHTYNPKMSLDISAVQDGRLCNSRLLSAVSSTKDDEPDPLILEENDVDNMATNNKESAPSNGSGKNDSKGVLTQTLEMRENFQKQLQEIMSATSIVKPQGQRTSLSRSGCNSASSTPDSTRSARSGRSRVLEALRQSRQTVPDVNTEPSQNEQIIWDDPTAREERARLASNLQWPSCPTQYSELQVDIQNLEDSPFQKPLHDSEIAKQAVCDPGNIRVTEAPKHPISEELETPIKDSHLIPTPQAPSIAFPLANPPVAPHPREKIITIEETHEELKKQYIFQLSSLNPQERIDYCHLIEKLGGLVIEKQCFDPTCTHIVVGHPLRNEKYLASVAAGKWVLHRSYLEACRTAGHFVQEEDYEWGSSSILDVLTGINVQQRRLALAAMRWRKKIQQRQESGIVEGAFSGWKVILHVDQSREAGFKRLLQSGGAKVLPGHSVPLFKEATHLFSDLNKLKPDDSGVNIAEAAAQNVYCLRTEYIADYLMQESPPHVENYCLPEAISFIQNNKELGTGLSQKRKAPTEKNKIKRPRVH

Target ORF information:

RefSeq Version	XM_017005637.1
Organism	Homo sapiens(human)
Definition	Homo sapiens topoisomerase (DNA) II binding protein 1 (TOPBP1), transcript variant X5, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017005637.1

ORF Insert Sequence:

ATGCTTTCTG AAGAACCATA TATCCATGCT AATTACCAGC CAGTGGAAAT TCCAGTTTCA 
CATAAGCCTG AAAGTAAAGC AGCTCTTTTA AAAAAGAAGA ACAGCAGCTT CTCTAAGAAA 
GACTTTGCTC CTAGTGAAAA GCATGAGCAA GCTGATGAAG ATCTGCTCTC TCAATATGAA 
AATGGTAGCT CCACAGTAGT TGAGGCTAAG ACGTCTGAAG CCAGGCCCTT TAATGATTCT 
ACTCATGCTG AGCCCTTGAA TGATTCTACT CACATTTCTT TGCAAGAAGA AAACCAGTCT 
TCTGTCAGTC ATTGTGTCCC TGATGTTTCT ACAATTACTG AAGAAGGCTT ATTTAGCCAA 
AAGAGTTTCC TTGTTTTGGG TTTTAGTAAT GAAAATGAAT CTAACATCGC AAACATCATA 
AAAGAAAATG CTGGGAAAAT CATGTCCCTT CTGAGCAGAA CTGTTGCGGA TTATGCTGTG 
GTTCCTCTGC TGGGGTGTGA AGTGGAAGCC ACTGTGGGAG AAGTTGTTAC AAATACATGG 
CTGGTTACTT GCATAGACTA TCAGACTTTG TTTGATCCAA AGTCGAATCC TCTCTTCACA 
CCAGTTCCAG TAATGACAGG AATGACTCCT TTAGAGGATT GTGTTATTTC ATTTAGCCAG 
TGTGCTGGAG CAGAAAAAGA GTCTTTAACA TTCCTAGCAA ACCTCCTTGG AGCAAGTGTT 
CAAGAATACT TTGTTCGCAA ATCCAATGCA AAGAAAGGCA TGTTTGCCAG TACTCATCTT 
ATACTGAAAG AACGTGGTGG CTCTAAATAT GAAGCTGCAA AGAAGTGGAA TTTACCTGCC 
GTTACTATAG CTTGGCTGTT GGAGACTGCT AGAACGGGAA AGAGAGCAGA CGAAAGCCAT 
TTTCTGATTG AAAATTCAAC TAAAGAAGAA CGAAGTTTGG AAACAGAAAT AACAAATGGA 
ATCAATCTAA ATTCAGATAC TGCAGAGCAT CCTGGCACAC GCCTGCAAAC TCACAGAAAA 
ACCGTCGTTA CACCTTTAGA TATGAACCGC TTTCAGAGTA AAGCTTTCCG TGCTGTGGTC 
TCACAACATG CCAGACAGGT CGCAGCCTCC CCAGCAGTAG GACAACCACT TCAGAAGGAG 
CCCTCGTTAC ACCTGGATAC ACCATCAAAA TTCCTGTCCA AGGACAAACT CTTCAAGCCT 
TCCTTTGATG TGAAGGATGC ACTTGCAGCC TTGGAAACTC CAGGACGTCC CAGCCAACAG 
AAAAGGAAAC CGAGTACGCC ACTCTCAGAA GTTATTGTCA AAAACTTGCA ACTTGCTTTG 
GCAAATAGCT CTCGAAATGC TGTCGCTCTT TCTGCCAGCC CTCAACTGAA AGAGGCCCAG 
TCAGAGAAGG AAGAAGCCCC AAAGCCACTT CACAAAGTAG TGGTATGTGT TAGTAAAAAA 
CTCAGTAAGA AGCAGAGTGA ACTAAATGGG ATCGCAGCCT CTCTAGGAGC AGATTACAGG 
TGGAGTTTTG ATGAAACAGT GACTCATTTC ATCTATCAAG GGCGGCCAAA TGACACTAAT 
CGGGAGTATA AATCTGTAAA AGAAAGAGGA GTACACATTG TTTCCGAGCA CTGGCTTTTA 
GATTGTGCCC AAGAGTGTAA ACATCTTCCT GAATCTCTTT ATCCACATAC TTATAATCCC 
AAAATGAGCT TGGATATCAG CGCAGTGCAA GATGGCCGGC TCTGTAATAG TCGACTACTC 
TCAGCTGTGT CTTCAACAAA GGATGATGAG CCAGATCCTT TGATTTTAGA AGAAAATGAT 
GTAGACAATA TGGCCACCAA TAATAAAGAG TCAGCACCAT CAAATGGAAG TGGAAAGAAT 
GACTCTAAAG GAGTTCTGAC ACAGACCTTA GAGATGAGAG AGAACTTTCA GAAGCAGTTA 
CAGGAGATAA TGTCTGCAAC ATCAATAGTG AAACCCCAAG GGCAGAGGAC TTCCCTTTCA 
AGAAGTGGTT GTAACAGCGC ATCTTCAACC CCTGACAGCA CTCGCTCTGC TCGCAGTGGA 
CGAAGTAGAG TCCTAGAGGC ACTGAGGCAG TCTCGTCAGA CAGTACCTGA TGTCAACACA 
GAGCCTTCCC AAAATGAACA GATCATTTGG GATGACCCTA CAGCAAGGGA GGAGAGAGCA 
AGGCTTGCCA GCAATTTGCA GTGGCCTAGT TGTCCCACAC AATACTCTGA GCTTCAGGTT 
GACATTCAAA ACTTGGAGGA TTCTCCTTTT CAAAAGCCTT TACATGATTC AGAAATTGCT 
AAACAGGCTG TCTGTGATCC TGGAAACATA CGTGTGACTG AAGCTCCCAA ACACCCAATC 
TCTGAAGAAC TGGAAACTCC CATAAAAGAC AGCCACCTGA TCCCTACGCC TCAAGCCCCC 
AGTATTGCCT TTCCACTCGC CAACCCCCCT GTGGCTCCGC ACCCTAGAGA AAAGATTATA 
ACGATAGAGG AGACTCATGA AGAATTAAAA AAACAGTACA TATTTCAGTT ATCATCTCTG 
AATCCTCAAG AACGTATTGA CTATTGTCAT CTGATTGAGA AACTAGGTGG ATTGGTGATA 
GAAAAGCAGT GCTTTGATCC CACCTGTACA CACATTGTTG TGGGACATCC ACTTCGAAAC 
GAGAAGTATT TAGCCTCAGT GGCAGCTGGG AAGTGGGTGC TTCATCGCTC CTACCTTGAA 
GCCTGCAGGA CTGCTGGACA CTTCGTGCAG GAAGAAGACT ATGAATGGGG AAGTAGTTCC 
ATACTTGATG TTCTGACTGG AATCAATGTA CAGCAACGAA GACTAGCACT TGCAGCAATG 
AGATGGAGAA AAAAAATCCA GCAAAGACAA GAATCTGGCA TTGTTGAGGG AGCATTTAGT 
GGGTGGAAGG TTATTTTACA TGTGGATCAG TCTCGAGAAG CAGGCTTCAA ACGCCTTCTT 
CAGTCAGGAG GAGCAAAGGT GCTACCTGGT CATTCTGTAC CTTTATTTAA AGAGGCCACA 
CATCTTTTTT CTGACTTGAA TAAACTGAAA CCAGATGACT CAGGAGTTAA TATAGCAGAA 
GCTGCTGCCC AGAACGTGTA CTGCTTGAGA ACAGAATACA TTGCTGATTA TCTCATGCAG 
GAATCACCTC CTCATGTAGA AAATTACTGT CTACCAGAAG CTATTTCATT TATTCAGAAT 
AATAAGGAAC TTGGGACTGG ATTATCACAA AAGAGGAAAG CTCCTACAGA AAAAAATAAA 
ATCAAACGAC CTAGAGTACA CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TOPBP1 ( XM_017005637.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_016861126.1 Homo sapiens DNA topoisomerase II binding protein 1 (TOPBP1), transcript variant X5, mRNA.

Price & Availability↑

CloneID	OHu93765
Clone ID Related Accession (Same CDS sequence)	XM_017005637.1 , XM_017005637.2
Accession Version	XM_017005637.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3264bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	DNA topoisomerase 2-binding protein 1 isoform X4
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000003.12) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_017005637.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCTTTCTG AAGAACCATA TATCCATGCT AATTACCAGC CAGTGGAAAT TCCAGTTTCA 
CATAAGCCTG AAAGTAAAGC AGCTCTTTTA AAAAAGAAGA ACAGCAGCTT CTCTAAGAAA 
GACTTTGCTC CTAGTGAAAA GCATGAGCAA GCTGATGAAG ATCTGCTCTC TCAATATGAA 
AATGGTAGCT CCACAGTAGT TGAGGCTAAG ACGTCTGAAG CCAGGCCCTT TAATGATTCT 
ACTCATGCTG AGCCCTTGAA TGATTCTACT CACATTTCTT TGCAAGAAGA AAACCAGTCT 
TCTGTCAGTC ATTGTGTCCC TGATGTTTCT ACAATTACTG AAGAAGGCTT ATTTAGCCAA 
AAGAGTTTCC TTGTTTTGGG TTTTAGTAAT GAAAATGAAT CTAACATCGC AAACATCATA 
AAAGAAAATG CTGGGAAAAT CATGTCCCTT CTGAGCAGAA CTGTTGCGGA TTATGCTGTG 
GTTCCTCTGC TGGGGTGTGA AGTGGAAGCC ACTGTGGGAG AAGTTGTTAC AAATACATGG 
CTGGTTACTT GCATAGACTA TCAGACTTTG TTTGATCCAA AGTCGAATCC TCTCTTCACA 
CCAGTTCCAG TAATGACAGG AATGACTCCT TTAGAGGATT GTGTTATTTC ATTTAGCCAG 
TGTGCTGGAG CAGAAAAAGA GTCTTTAACA TTCCTAGCAA ACCTCCTTGG AGCAAGTGTT 
CAAGAATACT TTGTTCGCAA ATCCAATGCA AAGAAAGGCA TGTTTGCCAG TACTCATCTT 
ATACTGAAAG AACGTGGTGG CTCTAAATAT GAAGCTGCAA AGAAGTGGAA TTTACCTGCC 
GTTACTATAG CTTGGCTGTT GGAGACTGCT AGAACGGGAA AGAGAGCAGA CGAAAGCCAT 
TTTCTGATTG AAAATTCAAC TAAAGAAGAA CGAAGTTTGG AAACAGAAAT AACAAATGGA 
ATCAATCTAA ATTCAGATAC TGCAGAGCAT CCTGGCACAC GCCTGCAAAC TCACAGAAAA 
ACCGTCGTTA CACCTTTAGA TATGAACCGC TTTCAGAGTA AAGCTTTCCG TGCTGTGGTC 
TCACAACATG CCAGACAGGT CGCAGCCTCC CCAGCAGTAG GACAACCACT TCAGAAGGAG 
CCCTCGTTAC ACCTGGATAC ACCATCAAAA TTCCTGTCCA AGGACAAACT CTTCAAGCCT 
TCCTTTGATG TGAAGGATGC ACTTGCAGCC TTGGAAACTC CAGGACGTCC CAGCCAACAG 
AAAAGGAAAC CGAGTACGCC ACTCTCAGAA GTTATTGTCA AAAACTTGCA ACTTGCTTTG 
GCAAATAGCT CTCGAAATGC TGTCGCTCTT TCTGCCAGCC CTCAACTGAA AGAGGCCCAG 
TCAGAGAAGG AAGAAGCCCC AAAGCCACTT CACAAAGTAG TGGTATGTGT TAGTAAAAAA 
CTCAGTAAGA AGCAGAGTGA ACTAAATGGG ATCGCAGCCT CTCTAGGAGC AGATTACAGG 
TGGAGTTTTG ATGAAACAGT GACTCATTTC ATCTATCAAG GGCGGCCAAA TGACACTAAT 
CGGGAGTATA AATCTGTAAA AGAAAGAGGA GTACACATTG TTTCCGAGCA CTGGCTTTTA 
GATTGTGCCC AAGAGTGTAA ACATCTTCCT GAATCTCTTT ATCCACATAC TTATAATCCC 
AAAATGAGCT TGGATATCAG CGCAGTGCAA GATGGCCGGC TCTGTAATAG TCGACTACTC 
TCAGCTGTGT CTTCAACAAA GGATGATGAG CCAGATCCTT TGATTTTAGA AGAAAATGAT 
GTAGACAATA TGGCCACCAA TAATAAAGAG TCAGCACCAT CAAATGGAAG TGGAAAGAAT 
GACTCTAAAG GAGTTCTGAC ACAGACCTTA GAGATGAGAG AGAACTTTCA GAAGCAGTTA 
CAGGAGATAA TGTCTGCAAC ATCAATAGTG AAACCCCAAG GGCAGAGGAC TTCCCTTTCA 
AGAAGTGGTT GTAACAGCGC ATCTTCAACC CCTGACAGCA CTCGCTCTGC TCGCAGTGGA 
CGAAGTAGAG TCCTAGAGGC ACTGAGGCAG TCTCGTCAGA CAGTACCTGA TGTCAACACA 
GAGCCTTCCC AAAATGAACA GATCATTTGG GATGACCCTA CAGCAAGGGA GGAGAGAGCA 
AGGCTTGCCA GCAATTTGCA GTGGCCTAGT TGTCCCACAC AATACTCTGA GCTTCAGGTT 
GACATTCAAA ACTTGGAGGA TTCTCCTTTT CAAAAGCCTT TACATGATTC AGAAATTGCT 
AAACAGGCTG TCTGTGATCC TGGAAACATA CGTGTGACTG AAGCTCCCAA ACACCCAATC 
TCTGAAGAAC TGGAAACTCC CATAAAAGAC AGCCACCTGA TCCCTACGCC TCAAGCCCCC 
AGTATTGCCT TTCCACTCGC CAACCCCCCT GTGGCTCCGC ACCCTAGAGA AAAGATTATA 
ACGATAGAGG AGACTCATGA AGAATTAAAA AAACAGTACA TATTTCAGTT ATCATCTCTG 
AATCCTCAAG AACGTATTGA CTATTGTCAT CTGATTGAGA AACTAGGTGG ATTGGTGATA 
GAAAAGCAGT GCTTTGATCC CACCTGTACA CACATTGTTG TGGGACATCC ACTTCGAAAC 
GAGAAGTATT TAGCCTCAGT GGCAGCTGGG AAGTGGGTGC TTCATCGCTC CTACCTTGAA 
GCCTGCAGGA CTGCTGGACA CTTCGTGCAG GAAGAAGACT ATGAATGGGG AAGTAGTTCC 
ATACTTGATG TTCTGACTGG AATCAATGTA CAGCAACGAA GACTAGCACT TGCAGCAATG 
AGATGGAGAA AAAAAATCCA GCAAAGACAA GAATCTGGCA TTGTTGAGGG AGCATTTAGT 
GGGTGGAAGG TTATTTTACA TGTGGATCAG TCTCGAGAAG CAGGCTTCAA ACGCCTTCTT 
CAGTCAGGAG GAGCAAAGGT GCTACCTGGT CATTCTGTAC CTTTATTTAA AGAGGCCACA 
CATCTTTTTT CTGACTTGAA TAAACTGAAA CCAGATGACT CAGGAGTTAA TATAGCAGAA 
GCTGCTGCCC AGAACGTGTA CTGCTTGAGA ACAGAATACA TTGCTGATTA TCTCATGCAG 
GAATCACCTC CTCATGTAGA AAATTACTGT CTACCAGAAG CTATTTCATT TATTCAGAAT 
AATAAGGAAC TTGGGACTGG ATTATCACAA AAGAGGAAAG CTCCTACAGA AAAAAATAAA 
ATCAAACGAC CTAGAGTACA CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016861126.1
CDS	1322..4585
Translation	MLSEEPYIHANYQPVEIPVSHKPESKAALLKKKNSSFSKKDFAPSEKHEQADEDLLSQYENGSSTVVEAKTSEARPFNDSTHAEPLNDSTHISLQEENQSSVSHCVPDVSTITEEGLFSQKSFLVLGFSNENESNIANIIKENAGKIMSLLSRTVADYAVVPLLGCEVEATVGEVVTNTWLVTCIDYQTLFDPKSNPLFTPVPVMTGMTPLEDCVISFSQCAGAEKESLTFLANLLGASVQEYFVRKSNAKKGMFASTHLILKERGGSKYEAAKKWNLPAVTIAWLLETARTGKRADESHFLIENSTKEERSLETEITNGINLNSDTAEHPGTRLQTHRKTVVTPLDMNRFQSKAFRAVVSQHARQVAASPAVGQPLQKEPSLHLDTPSKFLSKDKLFKPSFDVKDALAALETPGRPSQQKRKPSTPLSEVIVKNLQLALANSSRNAVALSASPQLKEAQSEKEEAPKPLHKVVVCVSKKLSKKQSELNGIAASLGADYRWSFDETVTHFIYQGRPNDTNREYKSVKERGVHIVSEHWLLDCAQECKHLPESLYPHTYNPKMSLDISAVQDGRLCNSRLLSAVSSTKDDEPDPLILEENDVDNMATNNKESAPSNGSGKNDSKGVLTQTLEMRENFQKQLQEIMSATSIVKPQGQRTSLSRSGCNSASSTPDSTRSARSGRSRVLEALRQSRQTVPDVNTEPSQNEQIIWDDPTAREERARLASNLQWPSCPTQYSELQVDIQNLEDSPFQKPLHDSEIAKQAVCDPGNIRVTEAPKHPISEELETPIKDSHLIPTPQAPSIAFPLANPPVAPHPREKIITIEETHEELKKQYIFQLSSLNPQERIDYCHLIEKLGGLVIEKQCFDPTCTHIVVGHPLRNEKYLASVAAGKWVLHRSYLEACRTAGHFVQEEDYEWGSSSILDVLTGINVQQRRLALAAMRWRKKIQQRQESGIVEGAFSGWKVILHVDQSREAGFKRLLQSGGAKVLPGHSVPLFKEATHLFSDLNKLKPDDSGVNIAEAAAQNVYCLRTEYIADYLMQESPPHVENYCLPEAISFIQNNKELGTGLSQKRKAPTEKNKIKRPRVH

Target ORF information:

RefSeq Version	XM_017005637.2
Organism	Homo sapiens(human)
Definition	Homo sapiens DNA topoisomerase II binding protein 1 (TOPBP1), transcript variant X5, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017005637.2

ORF Insert Sequence:

ATGCTTTCTG AAGAACCATA TATCCATGCT AATTACCAGC CAGTGGAAAT TCCAGTTTCA 
CATAAGCCTG AAAGTAAAGC AGCTCTTTTA AAAAAGAAGA ACAGCAGCTT CTCTAAGAAA 
GACTTTGCTC CTAGTGAAAA GCATGAGCAA GCTGATGAAG ATCTGCTCTC TCAATATGAA 
AATGGTAGCT CCACAGTAGT TGAGGCTAAG ACGTCTGAAG CCAGGCCCTT TAATGATTCT 
ACTCATGCTG AGCCCTTGAA TGATTCTACT CACATTTCTT TGCAAGAAGA AAACCAGTCT 
TCTGTCAGTC ATTGTGTCCC TGATGTTTCT ACAATTACTG AAGAAGGCTT ATTTAGCCAA 
AAGAGTTTCC TTGTTTTGGG TTTTAGTAAT GAAAATGAAT CTAACATCGC AAACATCATA 
AAAGAAAATG CTGGGAAAAT CATGTCCCTT CTGAGCAGAA CTGTTGCGGA TTATGCTGTG 
GTTCCTCTGC TGGGGTGTGA AGTGGAAGCC ACTGTGGGAG AAGTTGTTAC AAATACATGG 
CTGGTTACTT GCATAGACTA TCAGACTTTG TTTGATCCAA AGTCGAATCC TCTCTTCACA 
CCAGTTCCAG TAATGACAGG AATGACTCCT TTAGAGGATT GTGTTATTTC ATTTAGCCAG 
TGTGCTGGAG CAGAAAAAGA GTCTTTAACA TTCCTAGCAA ACCTCCTTGG AGCAAGTGTT 
CAAGAATACT TTGTTCGCAA ATCCAATGCA AAGAAAGGCA TGTTTGCCAG TACTCATCTT 
ATACTGAAAG AACGTGGTGG CTCTAAATAT GAAGCTGCAA AGAAGTGGAA TTTACCTGCC 
GTTACTATAG CTTGGCTGTT GGAGACTGCT AGAACGGGAA AGAGAGCAGA CGAAAGCCAT 
TTTCTGATTG AAAATTCAAC TAAAGAAGAA CGAAGTTTGG AAACAGAAAT AACAAATGGA 
ATCAATCTAA ATTCAGATAC TGCAGAGCAT CCTGGCACAC GCCTGCAAAC TCACAGAAAA 
ACCGTCGTTA CACCTTTAGA TATGAACCGC TTTCAGAGTA AAGCTTTCCG TGCTGTGGTC 
TCACAACATG CCAGACAGGT CGCAGCCTCC CCAGCAGTAG GACAACCACT TCAGAAGGAG 
CCCTCGTTAC ACCTGGATAC ACCATCAAAA TTCCTGTCCA AGGACAAACT CTTCAAGCCT 
TCCTTTGATG TGAAGGATGC ACTTGCAGCC TTGGAAACTC CAGGACGTCC CAGCCAACAG 
AAAAGGAAAC CGAGTACGCC ACTCTCAGAA GTTATTGTCA AAAACTTGCA ACTTGCTTTG 
GCAAATAGCT CTCGAAATGC TGTCGCTCTT TCTGCCAGCC CTCAACTGAA AGAGGCCCAG 
TCAGAGAAGG AAGAAGCCCC AAAGCCACTT CACAAAGTAG TGGTATGTGT TAGTAAAAAA 
CTCAGTAAGA AGCAGAGTGA ACTAAATGGG ATCGCAGCCT CTCTAGGAGC AGATTACAGG 
TGGAGTTTTG ATGAAACAGT GACTCATTTC ATCTATCAAG GGCGGCCAAA TGACACTAAT 
CGGGAGTATA AATCTGTAAA AGAAAGAGGA GTACACATTG TTTCCGAGCA CTGGCTTTTA 
GATTGTGCCC AAGAGTGTAA ACATCTTCCT GAATCTCTTT ATCCACATAC TTATAATCCC 
AAAATGAGCT TGGATATCAG CGCAGTGCAA GATGGCCGGC TCTGTAATAG TCGACTACTC 
TCAGCTGTGT CTTCAACAAA GGATGATGAG CCAGATCCTT TGATTTTAGA AGAAAATGAT 
GTAGACAATA TGGCCACCAA TAATAAAGAG TCAGCACCAT CAAATGGAAG TGGAAAGAAT 
GACTCTAAAG GAGTTCTGAC ACAGACCTTA GAGATGAGAG AGAACTTTCA GAAGCAGTTA 
CAGGAGATAA TGTCTGCAAC ATCAATAGTG AAACCCCAAG GGCAGAGGAC TTCCCTTTCA 
AGAAGTGGTT GTAACAGCGC ATCTTCAACC CCTGACAGCA CTCGCTCTGC TCGCAGTGGA 
CGAAGTAGAG TCCTAGAGGC ACTGAGGCAG TCTCGTCAGA CAGTACCTGA TGTCAACACA 
GAGCCTTCCC AAAATGAACA GATCATTTGG GATGACCCTA CAGCAAGGGA GGAGAGAGCA 
AGGCTTGCCA GCAATTTGCA GTGGCCTAGT TGTCCCACAC AATACTCTGA GCTTCAGGTT 
GACATTCAAA ACTTGGAGGA TTCTCCTTTT CAAAAGCCTT TACATGATTC AGAAATTGCT 
AAACAGGCTG TCTGTGATCC TGGAAACATA CGTGTGACTG AAGCTCCCAA ACACCCAATC 
TCTGAAGAAC TGGAAACTCC CATAAAAGAC AGCCACCTGA TCCCTACGCC TCAAGCCCCC 
AGTATTGCCT TTCCACTCGC CAACCCCCCT GTGGCTCCGC ACCCTAGAGA AAAGATTATA 
ACGATAGAGG AGACTCATGA AGAATTAAAA AAACAGTACA TATTTCAGTT ATCATCTCTG 
AATCCTCAAG AACGTATTGA CTATTGTCAT CTGATTGAGA AACTAGGTGG ATTGGTGATA 
GAAAAGCAGT GCTTTGATCC CACCTGTACA CACATTGTTG TGGGACATCC ACTTCGAAAC 
GAGAAGTATT TAGCCTCAGT GGCAGCTGGG AAGTGGGTGC TTCATCGCTC CTACCTTGAA 
GCCTGCAGGA CTGCTGGACA CTTCGTGCAG GAAGAAGACT ATGAATGGGG AAGTAGTTCC 
ATACTTGATG TTCTGACTGG AATCAATGTA CAGCAACGAA GACTAGCACT TGCAGCAATG 
AGATGGAGAA AAAAAATCCA GCAAAGACAA GAATCTGGCA TTGTTGAGGG AGCATTTAGT 
GGGTGGAAGG TTATTTTACA TGTGGATCAG TCTCGAGAAG CAGGCTTCAA ACGCCTTCTT 
CAGTCAGGAG GAGCAAAGGT GCTACCTGGT CATTCTGTAC CTTTATTTAA AGAGGCCACA 
CATCTTTTTT CTGACTTGAA TAAACTGAAA CCAGATGACT CAGGAGTTAA TATAGCAGAA 
GCTGCTGCCC AGAACGTGTA CTGCTTGAGA ACAGAATACA TTGCTGATTA TCTCATGCAG 
GAATCACCTC CTCATGTAGA AAATTACTGT CTACCAGAAG CTATTTCATT TATTCAGAAT 
AATAAGGAAC TTGGGACTGG ATTATCACAA AAGAGGAAAG CTCCTACAGA AAAAAATAAA 
ATCAAACGAC CTAGAGTACA CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TOPBP1 ( XM_011512357.3 ) cDNA ORF clone, Homo sapiens(human) -> XP_011510659.1 Homo sapiens DNA topoisomerase II binding protein 1 (TOPBP1), transcript variant X4, mRNA.

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CloneID	OHu64678
Clone ID Related Accession (Same CDS sequence)	XM_011512357.3 , XM_011512357.2
Accession Version	XM_011512357.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3381bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	DNA topoisomerase 2-binding protein 1 isoform X3
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000003.12) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_011512357.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTCCAGAA ATGACAAAGA ACCGTTTTTT GTGAAGTTTT TAAAGTCTTC AGACAATTCC 
AAATGTTTTT TTAAAGCTCT CGAGTCCATA AAAGAATTCC AATCAGAAGA ATATCTTCAG 
ATTATTACAG AAGAAGAGGC ATTGAAGATA AAGGAGAATG ATAGATCACT TTATATCTGT 
GACCCTTTTA GTGGCGTTGT CTTTGATCAC CTCAAAAAGC TTGGCTGCAG AATTGTTGGT 
CCTCAAGTAG TCATATTTTG TATGCACCAC CAGCGATGTG TCCCAAGAGC CGAACATCCA 
GTTTATAATA TGGTTATGTC TGATGTAACC ATATCTTGTA CAAGTCTGGA AAAAGAAAAA 
AGGGAAGAAG TTCATAAATA TGTACAAATG ATGGGCGGAC GAGTATACAG AGACCTTAAT 
GTATCAGTAA CTCACCTTAT TGCAGGAGAA GTTGGTAGCA AAAAATATTT AGTTGCTGCA 
AACCTGAAGA AACCTATTTT GCTTCCCTCT TGGATAAAAA CACTTTGGGA GAAGTCACAA 
GAGAAAAAAA TAACTAGATA TACTGATATA AACATGGAAG ATTTCAAGTG TCCTATTTTT 
CTTGGTTGCA TAATCTGTGT GACTGGCTTA TGTGGCTTAG ACAGGAAAGA AGTTCAGCAA 
CTCACAGTTA AGCATGGAGG TCAATACATG GGACAATTGA AAATGAATGA ATGTACACAC 
CTCATTGTGC AAGAACCAAA AGGTCAGAAG TATGAGTGTG CCAAGAGATG GAATGTACAC 
TGTGTGACCA CACAGTGGTT TTTTGACAGT ATTGAGAAAG GTTTTTGTCA GGATGAATCC 
ATATACAAGA CAGAACCTAG ACCAGAAGCA AAGACTATGC CCAATTCTTC AACTCCTACC 
AGCCAGATCA ACACAATTGA TAGTCGTACT CTTTCAGATG TCAGCAATAT TTCCAACATA 
AATGCAAGTT GCGTAAGTGA ATCAATATGT AATTCACTTA ACAGCAAACT GGAGCCTACA 
CTTGAAAATC TAGAAAATCT GGATGTCAGT GCATTTCAAG CACCTGAAGA TTTATTAGAT 
GGTTGTCGGA TATATCTTTG CGGTTTTAGT GGCAGAAAGC TAGATAAACT GAGAAGACTT 
ATTAACAGTG GAGGTGGAGT TCGTTTTAAC CAGCTAAATG AAGATGTAAC TCATGTTATT 
GTGGGAGATT ATGATGATGA ATTGAAGCAG TTTTGGAATA AATCAGCCCA CAGGCCTCAT 
GTAGTGGGAG CAAAGTGGTT GCTAGAGTGT TTCAGTAAAG GTTATATGCT TTCTGAAGAA 
CCATATATCC ATGCTAATTA CCAGCCAGTG GAAATTCCAG TTTCACATAA GCCTGAAAGT 
AAAGCAGCTC TTTTAAAAAA GAAGAACAGC AGCTTCTCTA AGAAAGACTT TGCTCCTAGT 
GAAAAGCATG AGCAAGCTGA TGAAGATCTG CTCTCTCAAT ATGAAAATGG TAGCTCCACA 
GTAGTTGAGG CTAAGACGTC TGAAGCCAGG CCCTTTAATG ATTCTACTCA TGCTGAGCCC 
TTGAATGATT CTACTCACAT TTCTTTGCAA GAAGAAAACC AGTCTTCTGT CAGTCATTGT 
GTCCCTGATG TTTCTACAAT TACTGAAGAA GGCTTATTTA GCCAAAAGAG TTTCCTTGTT 
TTGGGTTTTA GTAATGAAAA TGAATCTAAC ATCGCAAACA TCATAAAAGA AAATGCTGGG 
AAAATCATGT CCCTTCTGAG CAGAACTGTT GCGGATTATG CTGTGGTTCC TCTGCTGGGG 
TGTGAAGTGG AAGCCACTGT GGGAGAAGTT GTTACAAATA CATGGCTGGT TACTTGCATA 
GACTATCAGA CTTTGTTTGA TCCAAAGTCG AATCCTCTCT TCACACCAGT TCCAGTAATG 
ACAGGAATGA CTCCTTTAGA GGATTGTGTT ATTTCATTTA GCCAGTGTGC TGGAGCAGAA 
AAAGAGTCTT TAACATTCCT AGCAAACCTC CTTGGAGCAA GTGTTCAAGA ATACTTTGTT 
CGCAAATCCA ATGCAAAGAA AGGCATGTTT GCCAGTACTC ATCTTATACT GAAAGAACGT 
GGTGGCTCTA AATATGAAGC TGCAAAGAAG TGGAATTTAC CTGCCGTTAC TATAGCTTGG 
CTGTTGGAGA CTGCTAGAAC GGGAAAGAGA GCAGACGAAA GCCATTTTCT GATTGAAAAT 
TCAACTAAAG AAGAACGAAG TTTGGAAACA GAAATAACAA ATGGAATCAA TCTAAATTCA 
GATACTGCAG AGCATCCTGG CACACGCCTG CAAACTCACA GAAAAACCGT CGTTACACCT 
TTAGATATGA ACCGCTTTCA GAGTAAAGCT TTCCGTGCTG TGGTCTCACA ACATGCCAGA 
CAGGTCGCAG CCTCCCCAGC AGTAGGACAA CCACTTCAGA AGGAGCCCTC GTTACACCTG 
GATACACCAT CAAAATTCCT GTCCAAGGAC AAACTCTTCA AGCCTTCCTT TGATGTGAAG 
GATGCACTTG CAGCCTTGGA AACTCCAGGA CGTCCCAGCC AACAGAAAAG GAAACCGAGT 
ACGCCACTCT CAGAAGTTAT TGTCAAAAAC TTGCAACTTG CTTTGGCAAA TAGCTCTCGA 
AATGCTGTCG CTCTTTCTGC CAGCCCTCAA CTGAAAGAGG CCCAGTCAGA GAAGGAAGAA 
GCCCCAAAGC CACTTCACAA AGTAGTGGTA TGTGTTAGTA AAAAACTCAG TAAGAAGCAG 
AGTGAACTAA ATGGGATCGC AGCCTCTCTA GGAGCAGATT ACAGGTGGAG TTTTGATGAA 
ACAGTGACTC ATTTCATCTA TCAAGGGCGG CCAAATGACA CTAATCGGGA GTATAAATCT 
GTAAAAGAAA GAGGAGTACA CATTGTTTCC GAGCACTGGC TTTTAGATTG TGCCCAAGAG 
TGTAAACATC TTCCTGAATC TCTTTATCCA CATACTTATA ATCCCAAAAT GAGCTTGGAT 
ATCAGCGCAG TGCAAGATGG CCGGCTCTGT AATAGTCGAC TACTCTCAGC TGTGTCTTCA 
ACAAAGGATG ATGAGCCAGA TCCTTTGATT TTAGAAGAAA ATGATGTAGA CAATATGGCC 
ACCAATAATA AAGAGTCAGC ACCATCAAAT GGAAGTGGAA AGAATGACTC TAAAGGAGTT 
CTGACACAGA CCTTAGAGAT GAGAGAGAAC TTTCAGAAGC AGTTACAGGA GATAATGTCT 
GCAACATCAA TAGTGAAACC CCAAGGGCAG AGGACTTCCC TTTCAAGAAG TGGTTGTAAC 
AGCGCATCTT CAACCCCTGA CAGCACTCGC TCTGCTCGCA GTGGACGAAG TAGAGTCCTA 
GAGGCACTGA GCTGTCTGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011510659.1
CDS	99..3479
Translation	MSRNDKEPFFVKFLKSSDNSKCFFKALESIKEFQSEEYLQIITEEEALKIKENDRSLYICDPFSGVVFDHLKKLGCRIVGPQVVIFCMHHQRCVPRAEHPVYNMVMSDVTISCTSLEKEKREEVHKYVQMMGGRVYRDLNVSVTHLIAGEVGSKKYLVAANLKKPILLPSWIKTLWEKSQEKKITRYTDINMEDFKCPIFLGCIICVTGLCGLDRKEVQQLTVKHGGQYMGQLKMNECTHLIVQEPKGQKYECAKRWNVHCVTTQWFFDSIEKGFCQDESIYKTEPRPEAKTMPNSSTPTSQINTIDSRTLSDVSNISNINASCVSESICNSLNSKLEPTLENLENLDVSAFQAPEDLLDGCRIYLCGFSGRKLDKLRRLINSGGGVRFNQLNEDVTHVIVGDYDDELKQFWNKSAHRPHVVGAKWLLECFSKGYMLSEEPYIHANYQPVEIPVSHKPESKAALLKKKNSSFSKKDFAPSEKHEQADEDLLSQYENGSSTVVEAKTSEARPFNDSTHAEPLNDSTHISLQEENQSSVSHCVPDVSTITEEGLFSQKSFLVLGFSNENESNIANIIKENAGKIMSLLSRTVADYAVVPLLGCEVEATVGEVVTNTWLVTCIDYQTLFDPKSNPLFTPVPVMTGMTPLEDCVISFSQCAGAEKESLTFLANLLGASVQEYFVRKSNAKKGMFASTHLILKERGGSKYEAAKKWNLPAVTIAWLLETARTGKRADESHFLIENSTKEERSLETEITNGINLNSDTAEHPGTRLQTHRKTVVTPLDMNRFQSKAFRAVVSQHARQVAASPAVGQPLQKEPSLHLDTPSKFLSKDKLFKPSFDVKDALAALETPGRPSQQKRKPSTPLSEVIVKNLQLALANSSRNAVALSASPQLKEAQSEKEEAPKPLHKVVVCVSKKLSKKQSELNGIAASLGADYRWSFDETVTHFIYQGRPNDTNREYKSVKERGVHIVSEHWLLDCAQECKHLPESLYPHTYNPKMSLDISAVQDGRLCNSRLLSAVSSTKDDEPDPLILEENDVDNMATNNKESAPSNGSGKNDSKGVLTQTLEMRENFQKQLQEIMSATSIVKPQGQRTSLSRSGCNSASSTPDSTRSARSGRSRVLEALSCL

Target ORF information:

RefSeq Version	XM_011512357.3
Organism	Homo sapiens(human)
Definition	Homo sapiens DNA topoisomerase II binding protein 1 (TOPBP1), transcript variant X4, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011512357.3

ORF Insert Sequence:

ATGTCCAGAA ATGACAAAGA ACCGTTTTTT GTGAAGTTTT TAAAGTCTTC AGACAATTCC 
AAATGTTTTT TTAAAGCTCT CGAGTCCATA AAAGAATTCC AATCAGAAGA ATATCTTCAG 
ATTATTACAG AAGAAGAGGC ATTGAAGATA AAGGAGAATG ATAGATCACT TTATATCTGT 
GACCCTTTTA GTGGCGTTGT CTTTGATCAC CTCAAAAAGC TTGGCTGCAG AATTGTTGGT 
CCTCAAGTAG TCATATTTTG TATGCACCAC CAGCGATGTG TCCCAAGAGC CGAACATCCA 
GTTTATAATA TGGTTATGTC TGATGTAACC ATATCTTGTA CAAGTCTGGA AAAAGAAAAA 
AGGGAAGAAG TTCATAAATA TGTACAAATG ATGGGCGGAC GAGTATACAG AGACCTTAAT 
GTATCAGTAA CTCACCTTAT TGCAGGAGAA GTTGGTAGCA AAAAATATTT AGTTGCTGCA 
AACCTGAAGA AACCTATTTT GCTTCCCTCT TGGATAAAAA CACTTTGGGA GAAGTCACAA 
GAGAAAAAAA TAACTAGATA TACTGATATA AACATGGAAG ATTTCAAGTG TCCTATTTTT 
CTTGGTTGCA TAATCTGTGT GACTGGCTTA TGTGGCTTAG ACAGGAAAGA AGTTCAGCAA 
CTCACAGTTA AGCATGGAGG TCAATACATG GGACAATTGA AAATGAATGA ATGTACACAC 
CTCATTGTGC AAGAACCAAA AGGTCAGAAG TATGAGTGTG CCAAGAGATG GAATGTACAC 
TGTGTGACCA CACAGTGGTT TTTTGACAGT ATTGAGAAAG GTTTTTGTCA GGATGAATCC 
ATATACAAGA CAGAACCTAG ACCAGAAGCA AAGACTATGC CCAATTCTTC AACTCCTACC 
AGCCAGATCA ACACAATTGA TAGTCGTACT CTTTCAGATG TCAGCAATAT TTCCAACATA 
AATGCAAGTT GCGTAAGTGA ATCAATATGT AATTCACTTA ACAGCAAACT GGAGCCTACA 
CTTGAAAATC TAGAAAATCT GGATGTCAGT GCATTTCAAG CACCTGAAGA TTTATTAGAT 
GGTTGTCGGA TATATCTTTG CGGTTTTAGT GGCAGAAAGC TAGATAAACT GAGAAGACTT 
ATTAACAGTG GAGGTGGAGT TCGTTTTAAC CAGCTAAATG AAGATGTAAC TCATGTTATT 
GTGGGAGATT ATGATGATGA ATTGAAGCAG TTTTGGAATA AATCAGCCCA CAGGCCTCAT 
GTAGTGGGAG CAAAGTGGTT GCTAGAGTGT TTCAGTAAAG GTTATATGCT TTCTGAAGAA 
CCATATATCC ATGCTAATTA CCAGCCAGTG GAAATTCCAG TTTCACATAA GCCTGAAAGT 
AAAGCAGCTC TTTTAAAAAA GAAGAACAGC AGCTTCTCTA AGAAAGACTT TGCTCCTAGT 
GAAAAGCATG AGCAAGCTGA TGAAGATCTG CTCTCTCAAT ATGAAAATGG TAGCTCCACA 
GTAGTTGAGG CTAAGACGTC TGAAGCCAGG CCCTTTAATG ATTCTACTCA TGCTGAGCCC 
TTGAATGATT CTACTCACAT TTCTTTGCAA GAAGAAAACC AGTCTTCTGT CAGTCATTGT 
GTCCCTGATG TTTCTACAAT TACTGAAGAA GGCTTATTTA GCCAAAAGAG TTTCCTTGTT 
TTGGGTTTTA GTAATGAAAA TGAATCTAAC ATCGCAAACA TCATAAAAGA AAATGCTGGG 
AAAATCATGT CCCTTCTGAG CAGAACTGTT GCGGATTATG CTGTGGTTCC TCTGCTGGGG 
TGTGAAGTGG AAGCCACTGT GGGAGAAGTT GTTACAAATA CATGGCTGGT TACTTGCATA 
GACTATCAGA CTTTGTTTGA TCCAAAGTCG AATCCTCTCT TCACACCAGT TCCAGTAATG 
ACAGGAATGA CTCCTTTAGA GGATTGTGTT ATTTCATTTA GCCAGTGTGC TGGAGCAGAA 
AAAGAGTCTT TAACATTCCT AGCAAACCTC CTTGGAGCAA GTGTTCAAGA ATACTTTGTT 
CGCAAATCCA ATGCAAAGAA AGGCATGTTT GCCAGTACTC ATCTTATACT GAAAGAACGT 
GGTGGCTCTA AATATGAAGC TGCAAAGAAG TGGAATTTAC CTGCCGTTAC TATAGCTTGG 
CTGTTGGAGA CTGCTAGAAC GGGAAAGAGA GCAGACGAAA GCCATTTTCT GATTGAAAAT 
TCAACTAAAG AAGAACGAAG TTTGGAAACA GAAATAACAA ATGGAATCAA TCTAAATTCA 
GATACTGCAG AGCATCCTGG CACACGCCTG CAAACTCACA GAAAAACCGT CGTTACACCT 
TTAGATATGA ACCGCTTTCA GAGTAAAGCT TTCCGTGCTG TGGTCTCACA ACATGCCAGA 
CAGGTCGCAG CCTCCCCAGC AGTAGGACAA CCACTTCAGA AGGAGCCCTC GTTACACCTG 
GATACACCAT CAAAATTCCT GTCCAAGGAC AAACTCTTCA AGCCTTCCTT TGATGTGAAG 
GATGCACTTG CAGCCTTGGA AACTCCAGGA CGTCCCAGCC AACAGAAAAG GAAACCGAGT 
ACGCCACTCT CAGAAGTTAT TGTCAAAAAC TTGCAACTTG CTTTGGCAAA TAGCTCTCGA 
AATGCTGTCG CTCTTTCTGC CAGCCCTCAA CTGAAAGAGG CCCAGTCAGA GAAGGAAGAA 
GCCCCAAAGC CACTTCACAA AGTAGTGGTA TGTGTTAGTA AAAAACTCAG TAAGAAGCAG 
AGTGAACTAA ATGGGATCGC AGCCTCTCTA GGAGCAGATT ACAGGTGGAG TTTTGATGAA 
ACAGTGACTC ATTTCATCTA TCAAGGGCGG CCAAATGACA CTAATCGGGA GTATAAATCT 
GTAAAAGAAA GAGGAGTACA CATTGTTTCC GAGCACTGGC TTTTAGATTG TGCCCAAGAG 
TGTAAACATC TTCCTGAATC TCTTTATCCA CATACTTATA ATCCCAAAAT GAGCTTGGAT 
ATCAGCGCAG TGCAAGATGG CCGGCTCTGT AATAGTCGAC TACTCTCAGC TGTGTCTTCA 
ACAAAGGATG ATGAGCCAGA TCCTTTGATT TTAGAAGAAA ATGATGTAGA CAATATGGCC 
ACCAATAATA AAGAGTCAGC ACCATCAAAT GGAAGTGGAA AGAATGACTC TAAAGGAGTT 
CTGACACAGA CCTTAGAGAT GAGAGAGAAC TTTCAGAAGC AGTTACAGGA GATAATGTCT 
GCAACATCAA TAGTGAAACC CCAAGGGCAG AGGACTTCCC TTTCAAGAAG TGGTTGTAAC 
AGCGCATCTT CAACCCCTGA CAGCACTCGC TCTGCTCGCA GTGGACGAAG TAGAGTCCTA 
GAGGCACTGA GCTGTCTGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TOPBP1 ( XM_011512357.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_011510659.1 Homo sapiens topoisomerase (DNA) II binding protein 1 (TOPBP1), transcript variant X4, mRNA.

Price & Availability↑

CloneID	OHu64678
Clone ID Related Accession (Same CDS sequence)	XM_011512357.3 , XM_011512357.2
Accession Version	XM_011512357.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3381bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-05
Organism	Homo sapiens(human)
Product	DNA topoisomerase 2-binding protein 1 isoform X3
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000003.12) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011512357.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTCCAGAA ATGACAAAGA ACCGTTTTTT GTGAAGTTTT TAAAGTCTTC AGACAATTCC 
AAATGTTTTT TTAAAGCTCT CGAGTCCATA AAAGAATTCC AATCAGAAGA ATATCTTCAG 
ATTATTACAG AAGAAGAGGC ATTGAAGATA AAGGAGAATG ATAGATCACT TTATATCTGT 
GACCCTTTTA GTGGCGTTGT CTTTGATCAC CTCAAAAAGC TTGGCTGCAG AATTGTTGGT 
CCTCAAGTAG TCATATTTTG TATGCACCAC CAGCGATGTG TCCCAAGAGC CGAACATCCA 
GTTTATAATA TGGTTATGTC TGATGTAACC ATATCTTGTA CAAGTCTGGA AAAAGAAAAA 
AGGGAAGAAG TTCATAAATA TGTACAAATG ATGGGCGGAC GAGTATACAG AGACCTTAAT 
GTATCAGTAA CTCACCTTAT TGCAGGAGAA GTTGGTAGCA AAAAATATTT AGTTGCTGCA 
AACCTGAAGA AACCTATTTT GCTTCCCTCT TGGATAAAAA CACTTTGGGA GAAGTCACAA 
GAGAAAAAAA TAACTAGATA TACTGATATA AACATGGAAG ATTTCAAGTG TCCTATTTTT 
CTTGGTTGCA TAATCTGTGT GACTGGCTTA TGTGGCTTAG ACAGGAAAGA AGTTCAGCAA 
CTCACAGTTA AGCATGGAGG TCAATACATG GGACAATTGA AAATGAATGA ATGTACACAC 
CTCATTGTGC AAGAACCAAA AGGTCAGAAG TATGAGTGTG CCAAGAGATG GAATGTACAC 
TGTGTGACCA CACAGTGGTT TTTTGACAGT ATTGAGAAAG GTTTTTGTCA GGATGAATCC 
ATATACAAGA CAGAACCTAG ACCAGAAGCA AAGACTATGC CCAATTCTTC AACTCCTACC 
AGCCAGATCA ACACAATTGA TAGTCGTACT CTTTCAGATG TCAGCAATAT TTCCAACATA 
AATGCAAGTT GCGTAAGTGA ATCAATATGT AATTCACTTA ACAGCAAACT GGAGCCTACA 
CTTGAAAATC TAGAAAATCT GGATGTCAGT GCATTTCAAG CACCTGAAGA TTTATTAGAT 
GGTTGTCGGA TATATCTTTG CGGTTTTAGT GGCAGAAAGC TAGATAAACT GAGAAGACTT 
ATTAACAGTG GAGGTGGAGT TCGTTTTAAC CAGCTAAATG AAGATGTAAC TCATGTTATT 
GTGGGAGATT ATGATGATGA ATTGAAGCAG TTTTGGAATA AATCAGCCCA CAGGCCTCAT 
GTAGTGGGAG CAAAGTGGTT GCTAGAGTGT TTCAGTAAAG GTTATATGCT TTCTGAAGAA 
CCATATATCC ATGCTAATTA CCAGCCAGTG GAAATTCCAG TTTCACATAA GCCTGAAAGT 
AAAGCAGCTC TTTTAAAAAA GAAGAACAGC AGCTTCTCTA AGAAAGACTT TGCTCCTAGT 
GAAAAGCATG AGCAAGCTGA TGAAGATCTG CTCTCTCAAT ATGAAAATGG TAGCTCCACA 
GTAGTTGAGG CTAAGACGTC TGAAGCCAGG CCCTTTAATG ATTCTACTCA TGCTGAGCCC 
TTGAATGATT CTACTCACAT TTCTTTGCAA GAAGAAAACC AGTCTTCTGT CAGTCATTGT 
GTCCCTGATG TTTCTACAAT TACTGAAGAA GGCTTATTTA GCCAAAAGAG TTTCCTTGTT 
TTGGGTTTTA GTAATGAAAA TGAATCTAAC ATCGCAAACA TCATAAAAGA AAATGCTGGG 
AAAATCATGT CCCTTCTGAG CAGAACTGTT GCGGATTATG CTGTGGTTCC TCTGCTGGGG 
TGTGAAGTGG AAGCCACTGT GGGAGAAGTT GTTACAAATA CATGGCTGGT TACTTGCATA 
GACTATCAGA CTTTGTTTGA TCCAAAGTCG AATCCTCTCT TCACACCAGT TCCAGTAATG 
ACAGGAATGA CTCCTTTAGA GGATTGTGTT ATTTCATTTA GCCAGTGTGC TGGAGCAGAA 
AAAGAGTCTT TAACATTCCT AGCAAACCTC CTTGGAGCAA GTGTTCAAGA ATACTTTGTT 
CGCAAATCCA ATGCAAAGAA AGGCATGTTT GCCAGTACTC ATCTTATACT GAAAGAACGT 
GGTGGCTCTA AATATGAAGC TGCAAAGAAG TGGAATTTAC CTGCCGTTAC TATAGCTTGG 
CTGTTGGAGA CTGCTAGAAC GGGAAAGAGA GCAGACGAAA GCCATTTTCT GATTGAAAAT 
TCAACTAAAG AAGAACGAAG TTTGGAAACA GAAATAACAA ATGGAATCAA TCTAAATTCA 
GATACTGCAG AGCATCCTGG CACACGCCTG CAAACTCACA GAAAAACCGT CGTTACACCT 
TTAGATATGA ACCGCTTTCA GAGTAAAGCT TTCCGTGCTG TGGTCTCACA ACATGCCAGA 
CAGGTCGCAG CCTCCCCAGC AGTAGGACAA CCACTTCAGA AGGAGCCCTC GTTACACCTG 
GATACACCAT CAAAATTCCT GTCCAAGGAC AAACTCTTCA AGCCTTCCTT TGATGTGAAG 
GATGCACTTG CAGCCTTGGA AACTCCAGGA CGTCCCAGCC AACAGAAAAG GAAACCGAGT 
ACGCCACTCT CAGAAGTTAT TGTCAAAAAC TTGCAACTTG CTTTGGCAAA TAGCTCTCGA 
AATGCTGTCG CTCTTTCTGC CAGCCCTCAA CTGAAAGAGG CCCAGTCAGA GAAGGAAGAA 
GCCCCAAAGC CACTTCACAA AGTAGTGGTA TGTGTTAGTA AAAAACTCAG TAAGAAGCAG 
AGTGAACTAA ATGGGATCGC AGCCTCTCTA GGAGCAGATT ACAGGTGGAG TTTTGATGAA 
ACAGTGACTC ATTTCATCTA TCAAGGGCGG CCAAATGACA CTAATCGGGA GTATAAATCT 
GTAAAAGAAA GAGGAGTACA CATTGTTTCC GAGCACTGGC TTTTAGATTG TGCCCAAGAG 
TGTAAACATC TTCCTGAATC TCTTTATCCA CATACTTATA ATCCCAAAAT GAGCTTGGAT 
ATCAGCGCAG TGCAAGATGG CCGGCTCTGT AATAGTCGAC TACTCTCAGC TGTGTCTTCA 
ACAAAGGATG ATGAGCCAGA TCCTTTGATT TTAGAAGAAA ATGATGTAGA CAATATGGCC 
ACCAATAATA AAGAGTCAGC ACCATCAAAT GGAAGTGGAA AGAATGACTC TAAAGGAGTT 
CTGACACAGA CCTTAGAGAT GAGAGAGAAC TTTCAGAAGC AGTTACAGGA GATAATGTCT 
GCAACATCAA TAGTGAAACC CCAAGGGCAG AGGACTTCCC TTTCAAGAAG TGGTTGTAAC 
AGCGCATCTT CAACCCCTGA CAGCACTCGC TCTGCTCGCA GTGGACGAAG TAGAGTCCTA 
GAGGCACTGA GCTGTCTGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011510659.1
CDS	204..3584
Translation	MSRNDKEPFFVKFLKSSDNSKCFFKALESIKEFQSEEYLQIITEEEALKIKENDRSLYICDPFSGVVFDHLKKLGCRIVGPQVVIFCMHHQRCVPRAEHPVYNMVMSDVTISCTSLEKEKREEVHKYVQMMGGRVYRDLNVSVTHLIAGEVGSKKYLVAANLKKPILLPSWIKTLWEKSQEKKITRYTDINMEDFKCPIFLGCIICVTGLCGLDRKEVQQLTVKHGGQYMGQLKMNECTHLIVQEPKGQKYECAKRWNVHCVTTQWFFDSIEKGFCQDESIYKTEPRPEAKTMPNSSTPTSQINTIDSRTLSDVSNISNINASCVSESICNSLNSKLEPTLENLENLDVSAFQAPEDLLDGCRIYLCGFSGRKLDKLRRLINSGGGVRFNQLNEDVTHVIVGDYDDELKQFWNKSAHRPHVVGAKWLLECFSKGYMLSEEPYIHANYQPVEIPVSHKPESKAALLKKKNSSFSKKDFAPSEKHEQADEDLLSQYENGSSTVVEAKTSEARPFNDSTHAEPLNDSTHISLQEENQSSVSHCVPDVSTITEEGLFSQKSFLVLGFSNENESNIANIIKENAGKIMSLLSRTVADYAVVPLLGCEVEATVGEVVTNTWLVTCIDYQTLFDPKSNPLFTPVPVMTGMTPLEDCVISFSQCAGAEKESLTFLANLLGASVQEYFVRKSNAKKGMFASTHLILKERGGSKYEAAKKWNLPAVTIAWLLETARTGKRADESHFLIENSTKEERSLETEITNGINLNSDTAEHPGTRLQTHRKTVVTPLDMNRFQSKAFRAVVSQHARQVAASPAVGQPLQKEPSLHLDTPSKFLSKDKLFKPSFDVKDALAALETPGRPSQQKRKPSTPLSEVIVKNLQLALANSSRNAVALSASPQLKEAQSEKEEAPKPLHKVVVCVSKKLSKKQSELNGIAASLGADYRWSFDETVTHFIYQGRPNDTNREYKSVKERGVHIVSEHWLLDCAQECKHLPESLYPHTYNPKMSLDISAVQDGRLCNSRLLSAVSSTKDDEPDPLILEENDVDNMATNNKESAPSNGSGKNDSKGVLTQTLEMRENFQKQLQEIMSATSIVKPQGQRTSLSRSGCNSASSTPDSTRSARSGRSRVLEALSCL

Target ORF information:

RefSeq Version	XM_011512357.2
Organism	Homo sapiens(human)
Definition	Homo sapiens topoisomerase (DNA) II binding protein 1 (TOPBP1), transcript variant X4, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011512357.2

ORF Insert Sequence:

ATGTCCAGAA ATGACAAAGA ACCGTTTTTT GTGAAGTTTT TAAAGTCTTC AGACAATTCC 
AAATGTTTTT TTAAAGCTCT CGAGTCCATA AAAGAATTCC AATCAGAAGA ATATCTTCAG 
ATTATTACAG AAGAAGAGGC ATTGAAGATA AAGGAGAATG ATAGATCACT TTATATCTGT 
GACCCTTTTA GTGGCGTTGT CTTTGATCAC CTCAAAAAGC TTGGCTGCAG AATTGTTGGT 
CCTCAAGTAG TCATATTTTG TATGCACCAC CAGCGATGTG TCCCAAGAGC CGAACATCCA 
GTTTATAATA TGGTTATGTC TGATGTAACC ATATCTTGTA CAAGTCTGGA AAAAGAAAAA 
AGGGAAGAAG TTCATAAATA TGTACAAATG ATGGGCGGAC GAGTATACAG AGACCTTAAT 
GTATCAGTAA CTCACCTTAT TGCAGGAGAA GTTGGTAGCA AAAAATATTT AGTTGCTGCA 
AACCTGAAGA AACCTATTTT GCTTCCCTCT TGGATAAAAA CACTTTGGGA GAAGTCACAA 
GAGAAAAAAA TAACTAGATA TACTGATATA AACATGGAAG ATTTCAAGTG TCCTATTTTT 
CTTGGTTGCA TAATCTGTGT GACTGGCTTA TGTGGCTTAG ACAGGAAAGA AGTTCAGCAA 
CTCACAGTTA AGCATGGAGG TCAATACATG GGACAATTGA AAATGAATGA ATGTACACAC 
CTCATTGTGC AAGAACCAAA AGGTCAGAAG TATGAGTGTG CCAAGAGATG GAATGTACAC 
TGTGTGACCA CACAGTGGTT TTTTGACAGT ATTGAGAAAG GTTTTTGTCA GGATGAATCC 
ATATACAAGA CAGAACCTAG ACCAGAAGCA AAGACTATGC CCAATTCTTC AACTCCTACC 
AGCCAGATCA ACACAATTGA TAGTCGTACT CTTTCAGATG TCAGCAATAT TTCCAACATA 
AATGCAAGTT GCGTAAGTGA ATCAATATGT AATTCACTTA ACAGCAAACT GGAGCCTACA 
CTTGAAAATC TAGAAAATCT GGATGTCAGT GCATTTCAAG CACCTGAAGA TTTATTAGAT 
GGTTGTCGGA TATATCTTTG CGGTTTTAGT GGCAGAAAGC TAGATAAACT GAGAAGACTT 
ATTAACAGTG GAGGTGGAGT TCGTTTTAAC CAGCTAAATG AAGATGTAAC TCATGTTATT 
GTGGGAGATT ATGATGATGA ATTGAAGCAG TTTTGGAATA AATCAGCCCA CAGGCCTCAT 
GTAGTGGGAG CAAAGTGGTT GCTAGAGTGT TTCAGTAAAG GTTATATGCT TTCTGAAGAA 
CCATATATCC ATGCTAATTA CCAGCCAGTG GAAATTCCAG TTTCACATAA GCCTGAAAGT 
AAAGCAGCTC TTTTAAAAAA GAAGAACAGC AGCTTCTCTA AGAAAGACTT TGCTCCTAGT 
GAAAAGCATG AGCAAGCTGA TGAAGATCTG CTCTCTCAAT ATGAAAATGG TAGCTCCACA 
GTAGTTGAGG CTAAGACGTC TGAAGCCAGG CCCTTTAATG ATTCTACTCA TGCTGAGCCC 
TTGAATGATT CTACTCACAT TTCTTTGCAA GAAGAAAACC AGTCTTCTGT CAGTCATTGT 
GTCCCTGATG TTTCTACAAT TACTGAAGAA GGCTTATTTA GCCAAAAGAG TTTCCTTGTT 
TTGGGTTTTA GTAATGAAAA TGAATCTAAC ATCGCAAACA TCATAAAAGA AAATGCTGGG 
AAAATCATGT CCCTTCTGAG CAGAACTGTT GCGGATTATG CTGTGGTTCC TCTGCTGGGG 
TGTGAAGTGG AAGCCACTGT GGGAGAAGTT GTTACAAATA CATGGCTGGT TACTTGCATA 
GACTATCAGA CTTTGTTTGA TCCAAAGTCG AATCCTCTCT TCACACCAGT TCCAGTAATG 
ACAGGAATGA CTCCTTTAGA GGATTGTGTT ATTTCATTTA GCCAGTGTGC TGGAGCAGAA 
AAAGAGTCTT TAACATTCCT AGCAAACCTC CTTGGAGCAA GTGTTCAAGA ATACTTTGTT 
CGCAAATCCA ATGCAAAGAA AGGCATGTTT GCCAGTACTC ATCTTATACT GAAAGAACGT 
GGTGGCTCTA AATATGAAGC TGCAAAGAAG TGGAATTTAC CTGCCGTTAC TATAGCTTGG 
CTGTTGGAGA CTGCTAGAAC GGGAAAGAGA GCAGACGAAA GCCATTTTCT GATTGAAAAT 
TCAACTAAAG AAGAACGAAG TTTGGAAACA GAAATAACAA ATGGAATCAA TCTAAATTCA 
GATACTGCAG AGCATCCTGG CACACGCCTG CAAACTCACA GAAAAACCGT CGTTACACCT 
TTAGATATGA ACCGCTTTCA GAGTAAAGCT TTCCGTGCTG TGGTCTCACA ACATGCCAGA 
CAGGTCGCAG CCTCCCCAGC AGTAGGACAA CCACTTCAGA AGGAGCCCTC GTTACACCTG 
GATACACCAT CAAAATTCCT GTCCAAGGAC AAACTCTTCA AGCCTTCCTT TGATGTGAAG 
GATGCACTTG CAGCCTTGGA AACTCCAGGA CGTCCCAGCC AACAGAAAAG GAAACCGAGT 
ACGCCACTCT CAGAAGTTAT TGTCAAAAAC TTGCAACTTG CTTTGGCAAA TAGCTCTCGA 
AATGCTGTCG CTCTTTCTGC CAGCCCTCAA CTGAAAGAGG CCCAGTCAGA GAAGGAAGAA 
GCCCCAAAGC CACTTCACAA AGTAGTGGTA TGTGTTAGTA AAAAACTCAG TAAGAAGCAG 
AGTGAACTAA ATGGGATCGC AGCCTCTCTA GGAGCAGATT ACAGGTGGAG TTTTGATGAA 
ACAGTGACTC ATTTCATCTA TCAAGGGCGG CCAAATGACA CTAATCGGGA GTATAAATCT 
GTAAAAGAAA GAGGAGTACA CATTGTTTCC GAGCACTGGC TTTTAGATTG TGCCCAAGAG 
TGTAAACATC TTCCTGAATC TCTTTATCCA CATACTTATA ATCCCAAAAT GAGCTTGGAT 
ATCAGCGCAG TGCAAGATGG CCGGCTCTGT AATAGTCGAC TACTCTCAGC TGTGTCTTCA 
ACAAAGGATG ATGAGCCAGA TCCTTTGATT TTAGAAGAAA ATGATGTAGA CAATATGGCC 
ACCAATAATA AAGAGTCAGC ACCATCAAAT GGAAGTGGAA AGAATGACTC TAAAGGAGTT 
CTGACACAGA CCTTAGAGAT GAGAGAGAAC TTTCAGAAGC AGTTACAGGA GATAATGTCT 
GCAACATCAA TAGTGAAACC CCAAGGGCAG AGGACTTCCC TTTCAAGAAG TGGTTGTAAC 
AGCGCATCTT CAACCCCTGA CAGCACTCGC TCTGCTCGCA GTGGACGAAG TAGAGTCCTA 
GAGGCACTGA GCTGTCTGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TOPBP1 ( NM_001363889.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001350818.1 Homo sapiens DNA topoisomerase II binding protein 1 (TOPBP1), transcript variant 2, mRNA.

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CloneID	OHu37681
Clone ID Related Accession (Same CDS sequence)	NM_001363889.2 , XM_005247076.3 , NM_001363889.1
Accession Version	NM_001363889.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 4554bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-15
Organism	Homo sapiens(human)
Product	DNA topoisomerase 2-binding protein 1 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC083905.20 and AC016255.24. On May 31, 2019 this sequence version replaced NM_001363889.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803614.22551.1, SRR1660807.143600.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END##

ATGTCCAGAA ATGACAAAGA ACCGTTTTTT GTGAAGTTTT TAAAGTCTTC AGACAATTCC 
AAATGTTTTT TTAAAGCTCT CGAGTCCATA AAAGAATTCC AATCAGAAGA ATATCTTCAG 
ATTATTACAG AAGAAGAGGC ATTGAAGATA AAGGAGAATG ATAGATCACT TTATATCTGT 
GACCCTTTTA GTGGCGTTGT CTTTGATCAC CTCAAAAAGC TTGGCTGCAG AATTGTTGGT 
CCTCAAGTAG TCATATTTTG TATGCACCAC CAGCGATGTG TCCCAAGAGC CGAACATCCA 
GTTTATAATA TGGTTATGTC TGATGTAACC ATATCTTGTA CAAGTCTGGA AAAAGAAAAA 
AGGGAAGAAG TTCATAAATA TGTACAAATG ATGGGCGGAC GAGTATACAG AGACCTTAAT 
GTATCAGTAA CTCACCTTAT TGCAGGAGAA GTTGGTAGCA AAAAATATTT AGTTGCTGCA 
AACCTGAAGA AACCTATTTT GCTTCCCTCT TGGATAAAAA CACTTTGGGA GAAGTCACAA 
GAGAAAAAAA TAACTAGATA TACTGATATA AACATGGAAG ATTTCAAGTG TCCTATTTTT 
CTTGGTTGCA TAATCTGTGT GACTGGCTTA TGTGGCTTAG ACAGGAAAGA AGTTCAGCAA 
CTCACAGTTA AGCATGGAGG TCAATACATG GGACAATTGA AAATGAATGA ATGTACACAC 
CTCATTGTGC AAGAACCAAA AGGTCAGAAG TATGAGTGTG CCAAGAGATG GAATGTACAC 
TGTGTGACCA CACAGTGGTT TTTTGACAGT ATTGAGAAAG GTTTTTGTCA GGATGAATCC 
ATATACAAGA CAGAACCTAG ACCAGAAGCA AAGACTATGC CCAATTCTTC AACTCCTACC 
AGCCAGATCA ACACAATTGA TAATGTCAGC AATATTTCCA ACATAAATGC AAGTTGCGTA 
AGTGAATCAA TATGTAATTC ACTTAACAGC AAACTGGAGC CTACACTTGA AAATCTAGAA 
AATCTGGATG TCAGTGCATT TCAAGCACCT GAAGATTTAT TAGATGGTTG TCGGATATAT 
CTTTGCGGTT TTAGTGGCAG AAAGCTAGAT AAACTGAGAA GACTTATTAA CAGTGGAGGT 
GGAGTTCGTT TTAACCAGCT AAATGAAGAT GTAACTCATG TTATTGTGGG AGATTATGAT 
GATGAATTGA AGCAGTTTTG GAATAAATCA GCCCACAGGC CTCATGTAGT GGGAGCAAAG 
TGGTTGCTAG AGTGTTTCAG TAAAGGTTAT ATGCTTTCTG AAGAACCATA TATCCATGCT 
AATTACCAGC CAGTGGAAAT TCCAGTTTCA CATAAGCCTG AAAGTAAAGC AGCTCTTTTA 
AAAAAGAAGA ACAGCAGCTT CTCTAAGAAA GACTTTGCTC CTAGTGAAAA GCATGAGCAA 
GCTGATGAAG ATCTGCTCTC TCAATATGAA AATGGTAGCT CCACAGTAGT TGAGGCTAAG 
ACGTCTGAAG CCAGGCCCTT TAATGATTCT ACTCATGCTG AGCCCTTGAA TGATTCTACT 
CACATTTCTT TGCAAGAAGA AAACCAGTCT TCTGTCAGTC ATTGTGTCCC TGATGTTTCT 
ACAATTACTG AAGAAGGCTT ATTTAGCCAA AAGAGTTTCC TTGTTTTGGG TTTTAGTAAT 
GAAAATGAAT CTAACATCGC AAACATCATA AAAGAAAATG CTGGGAAAAT CATGTCCCTT 
CTGAGCAGAA CTGTTGCGGA TTATGCTGTG GTTCCTCTGC TGGGGTGTGA AGTGGAAGCC 
ACTGTGGGAG AAGTTGTTAC AAATACATGG CTGGTTACTT GCATAGACTA TCAGACTTTG 
TTTGATCCAA AGTCGAATCC TCTCTTCACA CCAGTTCCAG TAATGACAGG AATGACTCCT 
TTAGAGGATT GTGTTATTTC ATTTAGCCAG TGTGCTGGAG CAGAAAAAGA GTCTTTAACA 
TTCCTAGCAA ACCTCCTTGG AGCAAGTGTT CAAGAATACT TTGTTCGCAA ATCCAATGCA 
AAGAAAGGCA TGTTTGCCAG TACTCATCTT ATACTGAAAG AACGTGGTGG CTCTAAATAT 
GAAGCTGCAA AGAAGTGGAA TTTACCTGCC GTTACTATAG CTTGGCTGTT GGAGACTGCT 
AGAACGGGAA AGAGAGCAGA CGAAAGCCAT TTTCTGATTG AAAATTCAAC TAAAGAAGAA 
CGAAGTTTGG AAACAGAAAT AACAAATGGA ATCAATCTAA ATTCAGATAC TGCAGAGCAT 
CCTGGCACAC GCCTGCAAAC TCACAGAAAA ACCGTCGTTA CACCTTTAGA TATGAACCGC 
TTTCAGAGTA AAGCTTTCCG TGCTGTGGTC TCACAACATG CCAGACAGGT CGCAGCCTCC 
CCAGCAGTAG GACAACCACT TCAGAAGGAG CCCTCGTTAC ACCTGGATAC ACCATCAAAA 
TTCCTGTCCA AGGACAAACT CTTCAAGCCT TCCTTTGATG TGAAGGATGC ACTTGCAGCC 
TTGGAAACTC CAGGACGTCC CAGCCAACAG AAAAGGAAAC CGAGTACGCC ACTCTCAGAA 
GTTATTGTCA AAAACTTGCA ACTTGCTTTG GCAAATAGCT CTCGAAATGC TGTCGCTCTT 
TCTGCCAGCC CTCAACTGAA AGAGGCCCAG TCAGAGAAGG AAGAAGCCCC AAAGCCACTT 
CACAAAGTAG TGGTATGTGT TAGTAAAAAA CTCAGTAAGA AGCAGAGTGA ACTAAATGGG 
ATCGCAGCCT CTCTAGGAGC AGATTACAGG TGGAGTTTTG ATGAAACAGT GACTCATTTC 
ATCTATCAAG GGCGGCCAAA TGACACTAAT CGGGAGTATA AATCTGTAAA AGAAAGAGGA 
GTACACATTG TTTCCGAGCA CTGGCTTTTA GATTGTGCCC AAGAGTGTAA ACATCTTCCT 
GAATCTCTTT ATCCACATAC TTATAATCCC AAAATGAGCT TGGATATCAG CGCAGTGCAA 
GATGGCCGGC TCTGTAATAG TCGACTACTC TCAGCTGTGT CTTCAACAAA GGATGATGAG 
CCAGATCCTT TGATTTTAGA AGAAAATGAT GTAGACAATA TGGCCACCAA TAATAAAGAG 
TCAGCACCAT CAAATGGAAG TGGAAAGAAT GACTCTAAAG GAGTTCTGAC ACAGACCTTA 
GAGATGAGAG AGAACTTTCA GAAGCAGTTA CAGGAGATAA TGTCTGCAAC ATCAATAGTG 
AAACCCCAAG GGCAGAGGAC TTCCCTTTCA AGAAGTGGTT GTAACAGCGC ATCTTCAACC 
CCTGACAGCA CTCGCTCTGC TCGCAGTGGA CGAAGTAGAG TCCTAGAGGC ACTGAGGCAG 
TCTCGTCAGA CAGTACCTGA TGTCAACACA GAGCCTTCCC AAAATGAACA GATCATTTGG 
GATGACCCTA CAGCAAGGGA GGAGAGAGCA AGGCTTGCCA GCAATTTGCA GTGGCCTAGT 
TGTCCCACAC AATACTCTGA GCTTCAGGTT GACATTCAAA ACTTGGAGGA TTCTCCTTTT 
CAAAAGCCTT TACATGATTC AGAAATTGCT AAACAGGCTG TCTGTGATCC TGGAAACATA 
CGTGTGACTG AAGCTCCCAA ACACCCAATC TCTGAAGAAC TGGAAACTCC CATAAAAGAC 
AGCCACCTGA TCCCTACGCC TCAAGCCCCC AGTATTGCCT TTCCACTCGC CAACCCCCCT 
GTGGCTCCGC ACCCTAGAGA AAAGATTATA ACGATAGAGG AGACTCATGA AGAATTAAAA 
AAACAGTACA TATTTCAGTT ATCATCTCTG AATCCTCAAG AACGTATTGA CTATTGTCAT 
CTGATTGAGA AACTAGGTGG ATTGGTGATA GAAAAGCAGT GCTTTGATCC CACCTGTACA 
CACATTGTTG TGGGACATCC ACTTCGAAAC GAGAAGTATT TAGCCTCAGT GGCAGCTGGG 
AAGTGGGTGC TTCATCGCTC CTACCTTGAA GCCTGCAGGA CTGCTGGACA CTTCGTGCAG 
GAAGAAGACT ATGAATGGGG AAGTAGTTCC ATACTTGATG TTCTGACTGG AATCAATGTA 
CAGCAACGAA GACTAGCACT TGCAGCAATG AGATGGAGAA AAAAAATCCA GCAAAGACAA 
GAATCTGGCA TTGTTGAGGG AGCATTTAGT GGGTGGAAGG TTATTTTACA TGTGGATCAG 
TCTCGAGAAG CAGGCTTCAA ACGCCTTCTT CAGTCAGGAG GAGCAAAGGT GCTACCTGGT 
CATTCTGTAC CTTTATTTAA AGAGGCCACA CATCTTTTTT CTGACTTGAA TAAACTGAAA 
CCAGATGACT CAGGAGTTAA TATAGCAGAA GCTGCTGCCC AGAACGTGTA CTGCTTGAGA 
ACAGAATACA TTGCTGATTA TCTCATGCAG GAATCACCTC CTCATGTAGA AAATTACTGT 
CTACCAGAAG CTATTTCATT TATTCAGAAT AATAAGGAAC TTGGGACTGG ATTATCACAA 
AAGAGGAAAG CTCCTACAGA AAAAAATAAA ATCAAACGAC CTAGAGTACA CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001350818.1
CDS	181..4734
Translation	MSRNDKEPFFVKFLKSSDNSKCFFKALESIKEFQSEEYLQIITEEEALKIKENDRSLYICDPFSGVVFDHLKKLGCRIVGPQVVIFCMHHQRCVPRAEHPVYNMVMSDVTISCTSLEKEKREEVHKYVQMMGGRVYRDLNVSVTHLIAGEVGSKKYLVAANLKKPILLPSWIKTLWEKSQEKKITRYTDINMEDFKCPIFLGCIICVTGLCGLDRKEVQQLTVKHGGQYMGQLKMNECTHLIVQEPKGQKYECAKRWNVHCVTTQWFFDSIEKGFCQDESIYKTEPRPEAKTMPNSSTPTSQINTIDNVSNISNINASCVSESICNSLNSKLEPTLENLENLDVSAFQAPEDLLDGCRIYLCGFSGRKLDKLRRLINSGGGVRFNQLNEDVTHVIVGDYDDELKQFWNKSAHRPHVVGAKWLLECFSKGYMLSEEPYIHANYQPVEIPVSHKPESKAALLKKKNSSFSKKDFAPSEKHEQADEDLLSQYENGSSTVVEAKTSEARPFNDSTHAEPLNDSTHISLQEENQSSVSHCVPDVSTITEEGLFSQKSFLVLGFSNENESNIANIIKENAGKIMSLLSRTVADYAVVPLLGCEVEATVGEVVTNTWLVTCIDYQTLFDPKSNPLFTPVPVMTGMTPLEDCVISFSQCAGAEKESLTFLANLLGASVQEYFVRKSNAKKGMFASTHLILKERGGSKYEAAKKWNLPAVTIAWLLETARTGKRADESHFLIENSTKEERSLETEITNGINLNSDTAEHPGTRLQTHRKTVVTPLDMNRFQSKAFRAVVSQHARQVAASPAVGQPLQKEPSLHLDTPSKFLSKDKLFKPSFDVKDALAALETPGRPSQQKRKPSTPLSEVIVKNLQLALANSSRNAVALSASPQLKEAQSEKEEAPKPLHKVVVCVSKKLSKKQSELNGIAASLGADYRWSFDETVTHFIYQGRPNDTNREYKSVKERGVHIVSEHWLLDCAQECKHLPESLYPHTYNPKMSLDISAVQDGRLCNSRLLSAVSSTKDDEPDPLILEENDVDNMATNNKESAPSNGSGKNDSKGVLTQTLEMRENFQKQLQEIMSATSIVKPQGQRTSLSRSGCNSASSTPDSTRSARSGRSRVLEALRQSRQTVPDVNTEPSQNEQIIWDDPTAREERARLASNLQWPSCPTQYSELQVDIQNLEDSPFQKPLHDSEIAKQAVCDPGNIRVTEAPKHPISEELETPIKDSHLIPTPQAPSIAFPLANPPVAPHPREKIITIEETHEELKKQYIFQLSSLNPQERIDYCHLIEKLGGLVIEKQCFDPTCTHIVVGHPLRNEKYLASVAAGKWVLHRSYLEACRTAGHFVQEEDYEWGSSSILDVLTGINVQQRRLALAAMRWRKKIQQRQESGIVEGAFSGWKVILHVDQSREAGFKRLLQSGGAKVLPGHSVPLFKEATHLFSDLNKLKPDDSGVNIAEAAAQNVYCLRTEYIADYLMQESPPHVENYCLPEAISFIQNNKELGTGLSQKRKAPTEKNKIKRPRVH

Target ORF information:

RefSeq Version	NM_001363889.2
Organism	Homo sapiens(human)
Definition	Homo sapiens DNA topoisomerase II binding protein 1 (TOPBP1), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001363889.2

ORF Insert Sequence:

ATGTCCAGAA ATGACAAAGA ACCGTTTTTT GTGAAGTTTT TAAAGTCTTC AGACAATTCC 
AAATGTTTTT TTAAAGCTCT CGAGTCCATA AAAGAATTCC AATCAGAAGA ATATCTTCAG 
ATTATTACAG AAGAAGAGGC ATTGAAGATA AAGGAGAATG ATAGATCACT TTATATCTGT 
GACCCTTTTA GTGGCGTTGT CTTTGATCAC CTCAAAAAGC TTGGCTGCAG AATTGTTGGT 
CCTCAAGTAG TCATATTTTG TATGCACCAC CAGCGATGTG TCCCAAGAGC CGAACATCCA 
GTTTATAATA TGGTTATGTC TGATGTAACC ATATCTTGTA CAAGTCTGGA AAAAGAAAAA 
AGGGAAGAAG TTCATAAATA TGTACAAATG ATGGGCGGAC GAGTATACAG AGACCTTAAT 
GTATCAGTAA CTCACCTTAT TGCAGGAGAA GTTGGTAGCA AAAAATATTT AGTTGCTGCA 
AACCTGAAGA AACCTATTTT GCTTCCCTCT TGGATAAAAA CACTTTGGGA GAAGTCACAA 
GAGAAAAAAA TAACTAGATA TACTGATATA AACATGGAAG ATTTCAAGTG TCCTATTTTT 
CTTGGTTGCA TAATCTGTGT GACTGGCTTA TGTGGCTTAG ACAGGAAAGA AGTTCAGCAA 
CTCACAGTTA AGCATGGAGG TCAATACATG GGACAATTGA AAATGAATGA ATGTACACAC 
CTCATTGTGC AAGAACCAAA AGGTCAGAAG TATGAGTGTG CCAAGAGATG GAATGTACAC 
TGTGTGACCA CACAGTGGTT TTTTGACAGT ATTGAGAAAG GTTTTTGTCA GGATGAATCC 
ATATACAAGA CAGAACCTAG ACCAGAAGCA AAGACTATGC CCAATTCTTC AACTCCTACC 
AGCCAGATCA ACACAATTGA TAATGTCAGC AATATTTCCA ACATAAATGC AAGTTGCGTA 
AGTGAATCAA TATGTAATTC ACTTAACAGC AAACTGGAGC CTACACTTGA AAATCTAGAA 
AATCTGGATG TCAGTGCATT TCAAGCACCT GAAGATTTAT TAGATGGTTG TCGGATATAT 
CTTTGCGGTT TTAGTGGCAG AAAGCTAGAT AAACTGAGAA GACTTATTAA CAGTGGAGGT 
GGAGTTCGTT TTAACCAGCT AAATGAAGAT GTAACTCATG TTATTGTGGG AGATTATGAT 
GATGAATTGA AGCAGTTTTG GAATAAATCA GCCCACAGGC CTCATGTAGT GGGAGCAAAG 
TGGTTGCTAG AGTGTTTCAG TAAAGGTTAT ATGCTTTCTG AAGAACCATA TATCCATGCT 
AATTACCAGC CAGTGGAAAT TCCAGTTTCA CATAAGCCTG AAAGTAAAGC AGCTCTTTTA 
AAAAAGAAGA ACAGCAGCTT CTCTAAGAAA GACTTTGCTC CTAGTGAAAA GCATGAGCAA 
GCTGATGAAG ATCTGCTCTC TCAATATGAA AATGGTAGCT CCACAGTAGT TGAGGCTAAG 
ACGTCTGAAG CCAGGCCCTT TAATGATTCT ACTCATGCTG AGCCCTTGAA TGATTCTACT 
CACATTTCTT TGCAAGAAGA AAACCAGTCT TCTGTCAGTC ATTGTGTCCC TGATGTTTCT 
ACAATTACTG AAGAAGGCTT ATTTAGCCAA AAGAGTTTCC TTGTTTTGGG TTTTAGTAAT 
GAAAATGAAT CTAACATCGC AAACATCATA AAAGAAAATG CTGGGAAAAT CATGTCCCTT 
CTGAGCAGAA CTGTTGCGGA TTATGCTGTG GTTCCTCTGC TGGGGTGTGA AGTGGAAGCC 
ACTGTGGGAG AAGTTGTTAC AAATACATGG CTGGTTACTT GCATAGACTA TCAGACTTTG 
TTTGATCCAA AGTCGAATCC TCTCTTCACA CCAGTTCCAG TAATGACAGG AATGACTCCT 
TTAGAGGATT GTGTTATTTC ATTTAGCCAG TGTGCTGGAG CAGAAAAAGA GTCTTTAACA 
TTCCTAGCAA ACCTCCTTGG AGCAAGTGTT CAAGAATACT TTGTTCGCAA ATCCAATGCA 
AAGAAAGGCA TGTTTGCCAG TACTCATCTT ATACTGAAAG AACGTGGTGG CTCTAAATAT 
GAAGCTGCAA AGAAGTGGAA TTTACCTGCC GTTACTATAG CTTGGCTGTT GGAGACTGCT 
AGAACGGGAA AGAGAGCAGA CGAAAGCCAT TTTCTGATTG AAAATTCAAC TAAAGAAGAA 
CGAAGTTTGG AAACAGAAAT AACAAATGGA ATCAATCTAA ATTCAGATAC TGCAGAGCAT 
CCTGGCACAC GCCTGCAAAC TCACAGAAAA ACCGTCGTTA CACCTTTAGA TATGAACCGC 
TTTCAGAGTA AAGCTTTCCG TGCTGTGGTC TCACAACATG CCAGACAGGT CGCAGCCTCC 
CCAGCAGTAG GACAACCACT TCAGAAGGAG CCCTCGTTAC ACCTGGATAC ACCATCAAAA 
TTCCTGTCCA AGGACAAACT CTTCAAGCCT TCCTTTGATG TGAAGGATGC ACTTGCAGCC 
TTGGAAACTC CAGGACGTCC CAGCCAACAG AAAAGGAAAC CGAGTACGCC ACTCTCAGAA 
GTTATTGTCA AAAACTTGCA ACTTGCTTTG GCAAATAGCT CTCGAAATGC TGTCGCTCTT 
TCTGCCAGCC CTCAACTGAA AGAGGCCCAG TCAGAGAAGG AAGAAGCCCC AAAGCCACTT 
CACAAAGTAG TGGTATGTGT TAGTAAAAAA CTCAGTAAGA AGCAGAGTGA ACTAAATGGG 
ATCGCAGCCT CTCTAGGAGC AGATTACAGG TGGAGTTTTG ATGAAACAGT GACTCATTTC 
ATCTATCAAG GGCGGCCAAA TGACACTAAT CGGGAGTATA AATCTGTAAA AGAAAGAGGA 
GTACACATTG TTTCCGAGCA CTGGCTTTTA GATTGTGCCC AAGAGTGTAA ACATCTTCCT 
GAATCTCTTT ATCCACATAC TTATAATCCC AAAATGAGCT TGGATATCAG CGCAGTGCAA 
GATGGCCGGC TCTGTAATAG TCGACTACTC TCAGCTGTGT CTTCAACAAA GGATGATGAG 
CCAGATCCTT TGATTTTAGA AGAAAATGAT GTAGACAATA TGGCCACCAA TAATAAAGAG 
TCAGCACCAT CAAATGGAAG TGGAAAGAAT GACTCTAAAG GAGTTCTGAC ACAGACCTTA 
GAGATGAGAG AGAACTTTCA GAAGCAGTTA CAGGAGATAA TGTCTGCAAC ATCAATAGTG 
AAACCCCAAG GGCAGAGGAC TTCCCTTTCA AGAAGTGGTT GTAACAGCGC ATCTTCAACC 
CCTGACAGCA CTCGCTCTGC TCGCAGTGGA CGAAGTAGAG TCCTAGAGGC ACTGAGGCAG 
TCTCGTCAGA CAGTACCTGA TGTCAACACA GAGCCTTCCC AAAATGAACA GATCATTTGG 
GATGACCCTA CAGCAAGGGA GGAGAGAGCA AGGCTTGCCA GCAATTTGCA GTGGCCTAGT 
TGTCCCACAC AATACTCTGA GCTTCAGGTT GACATTCAAA ACTTGGAGGA TTCTCCTTTT 
CAAAAGCCTT TACATGATTC AGAAATTGCT AAACAGGCTG TCTGTGATCC TGGAAACATA 
CGTGTGACTG AAGCTCCCAA ACACCCAATC TCTGAAGAAC TGGAAACTCC CATAAAAGAC 
AGCCACCTGA TCCCTACGCC TCAAGCCCCC AGTATTGCCT TTCCACTCGC CAACCCCCCT 
GTGGCTCCGC ACCCTAGAGA AAAGATTATA ACGATAGAGG AGACTCATGA AGAATTAAAA 
AAACAGTACA TATTTCAGTT ATCATCTCTG AATCCTCAAG AACGTATTGA CTATTGTCAT 
CTGATTGAGA AACTAGGTGG ATTGGTGATA GAAAAGCAGT GCTTTGATCC CACCTGTACA 
CACATTGTTG TGGGACATCC ACTTCGAAAC GAGAAGTATT TAGCCTCAGT GGCAGCTGGG 
AAGTGGGTGC TTCATCGCTC CTACCTTGAA GCCTGCAGGA CTGCTGGACA CTTCGTGCAG 
GAAGAAGACT ATGAATGGGG AAGTAGTTCC ATACTTGATG TTCTGACTGG AATCAATGTA 
CAGCAACGAA GACTAGCACT TGCAGCAATG AGATGGAGAA AAAAAATCCA GCAAAGACAA 
GAATCTGGCA TTGTTGAGGG AGCATTTAGT GGGTGGAAGG TTATTTTACA TGTGGATCAG 
TCTCGAGAAG CAGGCTTCAA ACGCCTTCTT CAGTCAGGAG GAGCAAAGGT GCTACCTGGT 
CATTCTGTAC CTTTATTTAA AGAGGCCACA CATCTTTTTT CTGACTTGAA TAAACTGAAA 
CCAGATGACT CAGGAGTTAA TATAGCAGAA GCTGCTGCCC AGAACGTGTA CTGCTTGAGA 
ACAGAATACA TTGCTGATTA TCTCATGCAG GAATCACCTC CTCATGTAGA AAATTACTGT 
CTACCAGAAG CTATTTCATT TATTCAGAAT AATAAGGAAC TTGGGACTGG ATTATCACAA 
AAGAGGAAAG CTCCTACAGA AAAAAATAAA ATCAAACGAC CTAGAGTACA CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TOPBP1 ( NM_001363889.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001350818.1 Homo sapiens DNA topoisomerase II binding protein 1 (TOPBP1), transcript variant 2, mRNA.

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CloneID	OHu37681
Clone ID Related Accession (Same CDS sequence)	NM_001363889.2 , XM_005247076.3 , NM_001363889.1
Accession Version	NM_001363889.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 4554bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-27
Organism	Homo sapiens(human)
Product	DNA topoisomerase 2-binding protein 1 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC083905.20 and AC016255.24. On May 31, 2018 this sequence version replaced XM_005247076.4. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803614.22551.1, SRR1660809.149740.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END##

ATGTCCAGAA ATGACAAAGA ACCGTTTTTT GTGAAGTTTT TAAAGTCTTC AGACAATTCC 
AAATGTTTTT TTAAAGCTCT CGAGTCCATA AAAGAATTCC AATCAGAAGA ATATCTTCAG 
ATTATTACAG AAGAAGAGGC ATTGAAGATA AAGGAGAATG ATAGATCACT TTATATCTGT 
GACCCTTTTA GTGGCGTTGT CTTTGATCAC CTCAAAAAGC TTGGCTGCAG AATTGTTGGT 
CCTCAAGTAG TCATATTTTG TATGCACCAC CAGCGATGTG TCCCAAGAGC CGAACATCCA 
GTTTATAATA TGGTTATGTC TGATGTAACC ATATCTTGTA CAAGTCTGGA AAAAGAAAAA 
AGGGAAGAAG TTCATAAATA TGTACAAATG ATGGGCGGAC GAGTATACAG AGACCTTAAT 
GTATCAGTAA CTCACCTTAT TGCAGGAGAA GTTGGTAGCA AAAAATATTT AGTTGCTGCA 
AACCTGAAGA AACCTATTTT GCTTCCCTCT TGGATAAAAA CACTTTGGGA GAAGTCACAA 
GAGAAAAAAA TAACTAGATA TACTGATATA AACATGGAAG ATTTCAAGTG TCCTATTTTT 
CTTGGTTGCA TAATCTGTGT GACTGGCTTA TGTGGCTTAG ACAGGAAAGA AGTTCAGCAA 
CTCACAGTTA AGCATGGAGG TCAATACATG GGACAATTGA AAATGAATGA ATGTACACAC 
CTCATTGTGC AAGAACCAAA AGGTCAGAAG TATGAGTGTG CCAAGAGATG GAATGTACAC 
TGTGTGACCA CACAGTGGTT TTTTGACAGT ATTGAGAAAG GTTTTTGTCA GGATGAATCC 
ATATACAAGA CAGAACCTAG ACCAGAAGCA AAGACTATGC CCAATTCTTC AACTCCTACC 
AGCCAGATCA ACACAATTGA TAATGTCAGC AATATTTCCA ACATAAATGC AAGTTGCGTA 
AGTGAATCAA TATGTAATTC ACTTAACAGC AAACTGGAGC CTACACTTGA AAATCTAGAA 
AATCTGGATG TCAGTGCATT TCAAGCACCT GAAGATTTAT TAGATGGTTG TCGGATATAT 
CTTTGCGGTT TTAGTGGCAG AAAGCTAGAT AAACTGAGAA GACTTATTAA CAGTGGAGGT 
GGAGTTCGTT TTAACCAGCT AAATGAAGAT GTAACTCATG TTATTGTGGG AGATTATGAT 
GATGAATTGA AGCAGTTTTG GAATAAATCA GCCCACAGGC CTCATGTAGT GGGAGCAAAG 
TGGTTGCTAG AGTGTTTCAG TAAAGGTTAT ATGCTTTCTG AAGAACCATA TATCCATGCT 
AATTACCAGC CAGTGGAAAT TCCAGTTTCA CATAAGCCTG AAAGTAAAGC AGCTCTTTTA 
AAAAAGAAGA ACAGCAGCTT CTCTAAGAAA GACTTTGCTC CTAGTGAAAA GCATGAGCAA 
GCTGATGAAG ATCTGCTCTC TCAATATGAA AATGGTAGCT CCACAGTAGT TGAGGCTAAG 
ACGTCTGAAG CCAGGCCCTT TAATGATTCT ACTCATGCTG AGCCCTTGAA TGATTCTACT 
CACATTTCTT TGCAAGAAGA AAACCAGTCT TCTGTCAGTC ATTGTGTCCC TGATGTTTCT 
ACAATTACTG AAGAAGGCTT ATTTAGCCAA AAGAGTTTCC TTGTTTTGGG TTTTAGTAAT 
GAAAATGAAT CTAACATCGC AAACATCATA AAAGAAAATG CTGGGAAAAT CATGTCCCTT 
CTGAGCAGAA CTGTTGCGGA TTATGCTGTG GTTCCTCTGC TGGGGTGTGA AGTGGAAGCC 
ACTGTGGGAG AAGTTGTTAC AAATACATGG CTGGTTACTT GCATAGACTA TCAGACTTTG 
TTTGATCCAA AGTCGAATCC TCTCTTCACA CCAGTTCCAG TAATGACAGG AATGACTCCT 
TTAGAGGATT GTGTTATTTC ATTTAGCCAG TGTGCTGGAG CAGAAAAAGA GTCTTTAACA 
TTCCTAGCAA ACCTCCTTGG AGCAAGTGTT CAAGAATACT TTGTTCGCAA ATCCAATGCA 
AAGAAAGGCA TGTTTGCCAG TACTCATCTT ATACTGAAAG AACGTGGTGG CTCTAAATAT 
GAAGCTGCAA AGAAGTGGAA TTTACCTGCC GTTACTATAG CTTGGCTGTT GGAGACTGCT 
AGAACGGGAA AGAGAGCAGA CGAAAGCCAT TTTCTGATTG AAAATTCAAC TAAAGAAGAA 
CGAAGTTTGG AAACAGAAAT AACAAATGGA ATCAATCTAA ATTCAGATAC TGCAGAGCAT 
CCTGGCACAC GCCTGCAAAC TCACAGAAAA ACCGTCGTTA CACCTTTAGA TATGAACCGC 
TTTCAGAGTA AAGCTTTCCG TGCTGTGGTC TCACAACATG CCAGACAGGT CGCAGCCTCC 
CCAGCAGTAG GACAACCACT TCAGAAGGAG CCCTCGTTAC ACCTGGATAC ACCATCAAAA 
TTCCTGTCCA AGGACAAACT CTTCAAGCCT TCCTTTGATG TGAAGGATGC ACTTGCAGCC 
TTGGAAACTC CAGGACGTCC CAGCCAACAG AAAAGGAAAC CGAGTACGCC ACTCTCAGAA 
GTTATTGTCA AAAACTTGCA ACTTGCTTTG GCAAATAGCT CTCGAAATGC TGTCGCTCTT 
TCTGCCAGCC CTCAACTGAA AGAGGCCCAG TCAGAGAAGG AAGAAGCCCC AAAGCCACTT 
CACAAAGTAG TGGTATGTGT TAGTAAAAAA CTCAGTAAGA AGCAGAGTGA ACTAAATGGG 
ATCGCAGCCT CTCTAGGAGC AGATTACAGG TGGAGTTTTG ATGAAACAGT GACTCATTTC 
ATCTATCAAG GGCGGCCAAA TGACACTAAT CGGGAGTATA AATCTGTAAA AGAAAGAGGA 
GTACACATTG TTTCCGAGCA CTGGCTTTTA GATTGTGCCC AAGAGTGTAA ACATCTTCCT 
GAATCTCTTT ATCCACATAC TTATAATCCC AAAATGAGCT TGGATATCAG CGCAGTGCAA 
GATGGCCGGC TCTGTAATAG TCGACTACTC TCAGCTGTGT CTTCAACAAA GGATGATGAG 
CCAGATCCTT TGATTTTAGA AGAAAATGAT GTAGACAATA TGGCCACCAA TAATAAAGAG 
TCAGCACCAT CAAATGGAAG TGGAAAGAAT GACTCTAAAG GAGTTCTGAC ACAGACCTTA 
GAGATGAGAG AGAACTTTCA GAAGCAGTTA CAGGAGATAA TGTCTGCAAC ATCAATAGTG 
AAACCCCAAG GGCAGAGGAC TTCCCTTTCA AGAAGTGGTT GTAACAGCGC ATCTTCAACC 
CCTGACAGCA CTCGCTCTGC TCGCAGTGGA CGAAGTAGAG TCCTAGAGGC ACTGAGGCAG 
TCTCGTCAGA CAGTACCTGA TGTCAACACA GAGCCTTCCC AAAATGAACA GATCATTTGG 
GATGACCCTA CAGCAAGGGA GGAGAGAGCA AGGCTTGCCA GCAATTTGCA GTGGCCTAGT 
TGTCCCACAC AATACTCTGA GCTTCAGGTT GACATTCAAA ACTTGGAGGA TTCTCCTTTT 
CAAAAGCCTT TACATGATTC AGAAATTGCT AAACAGGCTG TCTGTGATCC TGGAAACATA 
CGTGTGACTG AAGCTCCCAA ACACCCAATC TCTGAAGAAC TGGAAACTCC CATAAAAGAC 
AGCCACCTGA TCCCTACGCC TCAAGCCCCC AGTATTGCCT TTCCACTCGC CAACCCCCCT 
GTGGCTCCGC ACCCTAGAGA AAAGATTATA ACGATAGAGG AGACTCATGA AGAATTAAAA 
AAACAGTACA TATTTCAGTT ATCATCTCTG AATCCTCAAG AACGTATTGA CTATTGTCAT 
CTGATTGAGA AACTAGGTGG ATTGGTGATA GAAAAGCAGT GCTTTGATCC CACCTGTACA 
CACATTGTTG TGGGACATCC ACTTCGAAAC GAGAAGTATT TAGCCTCAGT GGCAGCTGGG 
AAGTGGGTGC TTCATCGCTC CTACCTTGAA GCCTGCAGGA CTGCTGGACA CTTCGTGCAG 
GAAGAAGACT ATGAATGGGG AAGTAGTTCC ATACTTGATG TTCTGACTGG AATCAATGTA 
CAGCAACGAA GACTAGCACT TGCAGCAATG AGATGGAGAA AAAAAATCCA GCAAAGACAA 
GAATCTGGCA TTGTTGAGGG AGCATTTAGT GGGTGGAAGG TTATTTTACA TGTGGATCAG 
TCTCGAGAAG CAGGCTTCAA ACGCCTTCTT CAGTCAGGAG GAGCAAAGGT GCTACCTGGT 
CATTCTGTAC CTTTATTTAA AGAGGCCACA CATCTTTTTT CTGACTTGAA TAAACTGAAA 
CCAGATGACT CAGGAGTTAA TATAGCAGAA GCTGCTGCCC AGAACGTGTA CTGCTTGAGA 
ACAGAATACA TTGCTGATTA TCTCATGCAG GAATCACCTC CTCATGTAGA AAATTACTGT 
CTACCAGAAG CTATTTCATT TATTCAGAAT AATAAGGAAC TTGGGACTGG ATTATCACAA 
AAGAGGAAAG CTCCTACAGA AAAAAATAAA ATCAAACGAC CTAGAGTACA CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001350818.1
CDS	161..4714
Translation	MSRNDKEPFFVKFLKSSDNSKCFFKALESIKEFQSEEYLQIITEEEALKIKENDRSLYICDPFSGVVFDHLKKLGCRIVGPQVVIFCMHHQRCVPRAEHPVYNMVMSDVTISCTSLEKEKREEVHKYVQMMGGRVYRDLNVSVTHLIAGEVGSKKYLVAANLKKPILLPSWIKTLWEKSQEKKITRYTDINMEDFKCPIFLGCIICVTGLCGLDRKEVQQLTVKHGGQYMGQLKMNECTHLIVQEPKGQKYECAKRWNVHCVTTQWFFDSIEKGFCQDESIYKTEPRPEAKTMPNSSTPTSQINTIDNVSNISNINASCVSESICNSLNSKLEPTLENLENLDVSAFQAPEDLLDGCRIYLCGFSGRKLDKLRRLINSGGGVRFNQLNEDVTHVIVGDYDDELKQFWNKSAHRPHVVGAKWLLECFSKGYMLSEEPYIHANYQPVEIPVSHKPESKAALLKKKNSSFSKKDFAPSEKHEQADEDLLSQYENGSSTVVEAKTSEARPFNDSTHAEPLNDSTHISLQEENQSSVSHCVPDVSTITEEGLFSQKSFLVLGFSNENESNIANIIKENAGKIMSLLSRTVADYAVVPLLGCEVEATVGEVVTNTWLVTCIDYQTLFDPKSNPLFTPVPVMTGMTPLEDCVISFSQCAGAEKESLTFLANLLGASVQEYFVRKSNAKKGMFASTHLILKERGGSKYEAAKKWNLPAVTIAWLLETARTGKRADESHFLIENSTKEERSLETEITNGINLNSDTAEHPGTRLQTHRKTVVTPLDMNRFQSKAFRAVVSQHARQVAASPAVGQPLQKEPSLHLDTPSKFLSKDKLFKPSFDVKDALAALETPGRPSQQKRKPSTPLSEVIVKNLQLALANSSRNAVALSASPQLKEAQSEKEEAPKPLHKVVVCVSKKLSKKQSELNGIAASLGADYRWSFDETVTHFIYQGRPNDTNREYKSVKERGVHIVSEHWLLDCAQECKHLPESLYPHTYNPKMSLDISAVQDGRLCNSRLLSAVSSTKDDEPDPLILEENDVDNMATNNKESAPSNGSGKNDSKGVLTQTLEMRENFQKQLQEIMSATSIVKPQGQRTSLSRSGCNSASSTPDSTRSARSGRSRVLEALRQSRQTVPDVNTEPSQNEQIIWDDPTAREERARLASNLQWPSCPTQYSELQVDIQNLEDSPFQKPLHDSEIAKQAVCDPGNIRVTEAPKHPISEELETPIKDSHLIPTPQAPSIAFPLANPPVAPHPREKIITIEETHEELKKQYIFQLSSLNPQERIDYCHLIEKLGGLVIEKQCFDPTCTHIVVGHPLRNEKYLASVAAGKWVLHRSYLEACRTAGHFVQEEDYEWGSSSILDVLTGINVQQRRLALAAMRWRKKIQQRQESGIVEGAFSGWKVILHVDQSREAGFKRLLQSGGAKVLPGHSVPLFKEATHLFSDLNKLKPDDSGVNIAEAAAQNVYCLRTEYIADYLMQESPPHVENYCLPEAISFIQNNKELGTGLSQKRKAPTEKNKIKRPRVH

Target ORF information:

RefSeq Version	NM_001363889.1
Organism	Homo sapiens(human)
Definition	Homo sapiens DNA topoisomerase II binding protein 1 (TOPBP1), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001363889.1

ORF Insert Sequence:

ATGTCCAGAA ATGACAAAGA ACCGTTTTTT GTGAAGTTTT TAAAGTCTTC AGACAATTCC 
AAATGTTTTT TTAAAGCTCT CGAGTCCATA AAAGAATTCC AATCAGAAGA ATATCTTCAG 
ATTATTACAG AAGAAGAGGC ATTGAAGATA AAGGAGAATG ATAGATCACT TTATATCTGT 
GACCCTTTTA GTGGCGTTGT CTTTGATCAC CTCAAAAAGC TTGGCTGCAG AATTGTTGGT 
CCTCAAGTAG TCATATTTTG TATGCACCAC CAGCGATGTG TCCCAAGAGC CGAACATCCA 
GTTTATAATA TGGTTATGTC TGATGTAACC ATATCTTGTA CAAGTCTGGA AAAAGAAAAA 
AGGGAAGAAG TTCATAAATA TGTACAAATG ATGGGCGGAC GAGTATACAG AGACCTTAAT 
GTATCAGTAA CTCACCTTAT TGCAGGAGAA GTTGGTAGCA AAAAATATTT AGTTGCTGCA 
AACCTGAAGA AACCTATTTT GCTTCCCTCT TGGATAAAAA CACTTTGGGA GAAGTCACAA 
GAGAAAAAAA TAACTAGATA TACTGATATA AACATGGAAG ATTTCAAGTG TCCTATTTTT 
CTTGGTTGCA TAATCTGTGT GACTGGCTTA TGTGGCTTAG ACAGGAAAGA AGTTCAGCAA 
CTCACAGTTA AGCATGGAGG TCAATACATG GGACAATTGA AAATGAATGA ATGTACACAC 
CTCATTGTGC AAGAACCAAA AGGTCAGAAG TATGAGTGTG CCAAGAGATG GAATGTACAC 
TGTGTGACCA CACAGTGGTT TTTTGACAGT ATTGAGAAAG GTTTTTGTCA GGATGAATCC 
ATATACAAGA CAGAACCTAG ACCAGAAGCA AAGACTATGC CCAATTCTTC AACTCCTACC 
AGCCAGATCA ACACAATTGA TAATGTCAGC AATATTTCCA ACATAAATGC AAGTTGCGTA 
AGTGAATCAA TATGTAATTC ACTTAACAGC AAACTGGAGC CTACACTTGA AAATCTAGAA 
AATCTGGATG TCAGTGCATT TCAAGCACCT GAAGATTTAT TAGATGGTTG TCGGATATAT 
CTTTGCGGTT TTAGTGGCAG AAAGCTAGAT AAACTGAGAA GACTTATTAA CAGTGGAGGT 
GGAGTTCGTT TTAACCAGCT AAATGAAGAT GTAACTCATG TTATTGTGGG AGATTATGAT 
GATGAATTGA AGCAGTTTTG GAATAAATCA GCCCACAGGC CTCATGTAGT GGGAGCAAAG 
TGGTTGCTAG AGTGTTTCAG TAAAGGTTAT ATGCTTTCTG AAGAACCATA TATCCATGCT 
AATTACCAGC CAGTGGAAAT TCCAGTTTCA CATAAGCCTG AAAGTAAAGC AGCTCTTTTA 
AAAAAGAAGA ACAGCAGCTT CTCTAAGAAA GACTTTGCTC CTAGTGAAAA GCATGAGCAA 
GCTGATGAAG ATCTGCTCTC TCAATATGAA AATGGTAGCT CCACAGTAGT TGAGGCTAAG 
ACGTCTGAAG CCAGGCCCTT TAATGATTCT ACTCATGCTG AGCCCTTGAA TGATTCTACT 
CACATTTCTT TGCAAGAAGA AAACCAGTCT TCTGTCAGTC ATTGTGTCCC TGATGTTTCT 
ACAATTACTG AAGAAGGCTT ATTTAGCCAA AAGAGTTTCC TTGTTTTGGG TTTTAGTAAT 
GAAAATGAAT CTAACATCGC AAACATCATA AAAGAAAATG CTGGGAAAAT CATGTCCCTT 
CTGAGCAGAA CTGTTGCGGA TTATGCTGTG GTTCCTCTGC TGGGGTGTGA AGTGGAAGCC 
ACTGTGGGAG AAGTTGTTAC AAATACATGG CTGGTTACTT GCATAGACTA TCAGACTTTG 
TTTGATCCAA AGTCGAATCC TCTCTTCACA CCAGTTCCAG TAATGACAGG AATGACTCCT 
TTAGAGGATT GTGTTATTTC ATTTAGCCAG TGTGCTGGAG CAGAAAAAGA GTCTTTAACA 
TTCCTAGCAA ACCTCCTTGG AGCAAGTGTT CAAGAATACT TTGTTCGCAA ATCCAATGCA 
AAGAAAGGCA TGTTTGCCAG TACTCATCTT ATACTGAAAG AACGTGGTGG CTCTAAATAT 
GAAGCTGCAA AGAAGTGGAA TTTACCTGCC GTTACTATAG CTTGGCTGTT GGAGACTGCT 
AGAACGGGAA AGAGAGCAGA CGAAAGCCAT TTTCTGATTG AAAATTCAAC TAAAGAAGAA 
CGAAGTTTGG AAACAGAAAT AACAAATGGA ATCAATCTAA ATTCAGATAC TGCAGAGCAT 
CCTGGCACAC GCCTGCAAAC TCACAGAAAA ACCGTCGTTA CACCTTTAGA TATGAACCGC 
TTTCAGAGTA AAGCTTTCCG TGCTGTGGTC TCACAACATG CCAGACAGGT CGCAGCCTCC 
CCAGCAGTAG GACAACCACT TCAGAAGGAG CCCTCGTTAC ACCTGGATAC ACCATCAAAA 
TTCCTGTCCA AGGACAAACT CTTCAAGCCT TCCTTTGATG TGAAGGATGC ACTTGCAGCC 
TTGGAAACTC CAGGACGTCC CAGCCAACAG AAAAGGAAAC CGAGTACGCC ACTCTCAGAA 
GTTATTGTCA AAAACTTGCA ACTTGCTTTG GCAAATAGCT CTCGAAATGC TGTCGCTCTT 
TCTGCCAGCC CTCAACTGAA AGAGGCCCAG TCAGAGAAGG AAGAAGCCCC AAAGCCACTT 
CACAAAGTAG TGGTATGTGT TAGTAAAAAA CTCAGTAAGA AGCAGAGTGA ACTAAATGGG 
ATCGCAGCCT CTCTAGGAGC AGATTACAGG TGGAGTTTTG ATGAAACAGT GACTCATTTC 
ATCTATCAAG GGCGGCCAAA TGACACTAAT CGGGAGTATA AATCTGTAAA AGAAAGAGGA 
GTACACATTG TTTCCGAGCA CTGGCTTTTA GATTGTGCCC AAGAGTGTAA ACATCTTCCT 
GAATCTCTTT ATCCACATAC TTATAATCCC AAAATGAGCT TGGATATCAG CGCAGTGCAA 
GATGGCCGGC TCTGTAATAG TCGACTACTC TCAGCTGTGT CTTCAACAAA GGATGATGAG 
CCAGATCCTT TGATTTTAGA AGAAAATGAT GTAGACAATA TGGCCACCAA TAATAAAGAG 
TCAGCACCAT CAAATGGAAG TGGAAAGAAT GACTCTAAAG GAGTTCTGAC ACAGACCTTA 
GAGATGAGAG AGAACTTTCA GAAGCAGTTA CAGGAGATAA TGTCTGCAAC ATCAATAGTG 
AAACCCCAAG GGCAGAGGAC TTCCCTTTCA AGAAGTGGTT GTAACAGCGC ATCTTCAACC 
CCTGACAGCA CTCGCTCTGC TCGCAGTGGA CGAAGTAGAG TCCTAGAGGC ACTGAGGCAG 
TCTCGTCAGA CAGTACCTGA TGTCAACACA GAGCCTTCCC AAAATGAACA GATCATTTGG 
GATGACCCTA CAGCAAGGGA GGAGAGAGCA AGGCTTGCCA GCAATTTGCA GTGGCCTAGT 
TGTCCCACAC AATACTCTGA GCTTCAGGTT GACATTCAAA ACTTGGAGGA TTCTCCTTTT 
CAAAAGCCTT TACATGATTC AGAAATTGCT AAACAGGCTG TCTGTGATCC TGGAAACATA 
CGTGTGACTG AAGCTCCCAA ACACCCAATC TCTGAAGAAC TGGAAACTCC CATAAAAGAC 
AGCCACCTGA TCCCTACGCC TCAAGCCCCC AGTATTGCCT TTCCACTCGC CAACCCCCCT 
GTGGCTCCGC ACCCTAGAGA AAAGATTATA ACGATAGAGG AGACTCATGA AGAATTAAAA 
AAACAGTACA TATTTCAGTT ATCATCTCTG AATCCTCAAG AACGTATTGA CTATTGTCAT 
CTGATTGAGA AACTAGGTGG ATTGGTGATA GAAAAGCAGT GCTTTGATCC CACCTGTACA 
CACATTGTTG TGGGACATCC ACTTCGAAAC GAGAAGTATT TAGCCTCAGT GGCAGCTGGG 
AAGTGGGTGC TTCATCGCTC CTACCTTGAA GCCTGCAGGA CTGCTGGACA CTTCGTGCAG 
GAAGAAGACT ATGAATGGGG AAGTAGTTCC ATACTTGATG TTCTGACTGG AATCAATGTA 
CAGCAACGAA GACTAGCACT TGCAGCAATG AGATGGAGAA AAAAAATCCA GCAAAGACAA 
GAATCTGGCA TTGTTGAGGG AGCATTTAGT GGGTGGAAGG TTATTTTACA TGTGGATCAG 
TCTCGAGAAG CAGGCTTCAA ACGCCTTCTT CAGTCAGGAG GAGCAAAGGT GCTACCTGGT 
CATTCTGTAC CTTTATTTAA AGAGGCCACA CATCTTTTTT CTGACTTGAA TAAACTGAAA 
CCAGATGACT CAGGAGTTAA TATAGCAGAA GCTGCTGCCC AGAACGTGTA CTGCTTGAGA 
ACAGAATACA TTGCTGATTA TCTCATGCAG GAATCACCTC CTCATGTAGA AAATTACTGT 
CTACCAGAAG CTATTTCATT TATTCAGAAT AATAAGGAAC TTGGGACTGG ATTATCACAA 
AAGAGGAAAG CTCCTACAGA AAAAAATAAA ATCAAACGAC CTAGAGTACA CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TOPBP1 ( XM_005247076.3 ) cDNA ORF clone, Homo sapiens(human) -> XP_005247133.1 Homo sapiens topoisomerase (DNA) II binding protein 1 (TOPBP1), transcript variant X2, mRNA.

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CloneID	OHu37681
Clone ID Related Accession (Same CDS sequence)	NM_001363889.2 , XM_005247076.3 , NM_001363889.1
Accession Version	XM_005247076.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 4554bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-05
Organism	Homo sapiens(human)
Product	DNA topoisomerase 2-binding protein 1 isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000003.12) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_005247076.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTCCAGAA ATGACAAAGA ACCGTTTTTT GTGAAGTTTT TAAAGTCTTC AGACAATTCC 
AAATGTTTTT TTAAAGCTCT CGAGTCCATA AAAGAATTCC AATCAGAAGA ATATCTTCAG 
ATTATTACAG AAGAAGAGGC ATTGAAGATA AAGGAGAATG ATAGATCACT TTATATCTGT 
GACCCTTTTA GTGGCGTTGT CTTTGATCAC CTCAAAAAGC TTGGCTGCAG AATTGTTGGT 
CCTCAAGTAG TCATATTTTG TATGCACCAC CAGCGATGTG TCCCAAGAGC CGAACATCCA 
GTTTATAATA TGGTTATGTC TGATGTAACC ATATCTTGTA CAAGTCTGGA AAAAGAAAAA 
AGGGAAGAAG TTCATAAATA TGTACAAATG ATGGGCGGAC GAGTATACAG AGACCTTAAT 
GTATCAGTAA CTCACCTTAT TGCAGGAGAA GTTGGTAGCA AAAAATATTT AGTTGCTGCA 
AACCTGAAGA AACCTATTTT GCTTCCCTCT TGGATAAAAA CACTTTGGGA GAAGTCACAA 
GAGAAAAAAA TAACTAGATA TACTGATATA AACATGGAAG ATTTCAAGTG TCCTATTTTT 
CTTGGTTGCA TAATCTGTGT GACTGGCTTA TGTGGCTTAG ACAGGAAAGA AGTTCAGCAA 
CTCACAGTTA AGCATGGAGG TCAATACATG GGACAATTGA AAATGAATGA ATGTACACAC 
CTCATTGTGC AAGAACCAAA AGGTCAGAAG TATGAGTGTG CCAAGAGATG GAATGTACAC 
TGTGTGACCA CACAGTGGTT TTTTGACAGT ATTGAGAAAG GTTTTTGTCA GGATGAATCC 
ATATACAAGA CAGAACCTAG ACCAGAAGCA AAGACTATGC CCAATTCTTC AACTCCTACC 
AGCCAGATCA ACACAATTGA TAATGTCAGC AATATTTCCA ACATAAATGC AAGTTGCGTA 
AGTGAATCAA TATGTAATTC ACTTAACAGC AAACTGGAGC CTACACTTGA AAATCTAGAA 
AATCTGGATG TCAGTGCATT TCAAGCACCT GAAGATTTAT TAGATGGTTG TCGGATATAT 
CTTTGCGGTT TTAGTGGCAG AAAGCTAGAT AAACTGAGAA GACTTATTAA CAGTGGAGGT 
GGAGTTCGTT TTAACCAGCT AAATGAAGAT GTAACTCATG TTATTGTGGG AGATTATGAT 
GATGAATTGA AGCAGTTTTG GAATAAATCA GCCCACAGGC CTCATGTAGT GGGAGCAAAG 
TGGTTGCTAG AGTGTTTCAG TAAAGGTTAT ATGCTTTCTG AAGAACCATA TATCCATGCT 
AATTACCAGC CAGTGGAAAT TCCAGTTTCA CATAAGCCTG AAAGTAAAGC AGCTCTTTTA 
AAAAAGAAGA ACAGCAGCTT CTCTAAGAAA GACTTTGCTC CTAGTGAAAA GCATGAGCAA 
GCTGATGAAG ATCTGCTCTC TCAATATGAA AATGGTAGCT CCACAGTAGT TGAGGCTAAG 
ACGTCTGAAG CCAGGCCCTT TAATGATTCT ACTCATGCTG AGCCCTTGAA TGATTCTACT 
CACATTTCTT TGCAAGAAGA AAACCAGTCT TCTGTCAGTC ATTGTGTCCC TGATGTTTCT 
ACAATTACTG AAGAAGGCTT ATTTAGCCAA AAGAGTTTCC TTGTTTTGGG TTTTAGTAAT 
GAAAATGAAT CTAACATCGC AAACATCATA AAAGAAAATG CTGGGAAAAT CATGTCCCTT 
CTGAGCAGAA CTGTTGCGGA TTATGCTGTG GTTCCTCTGC TGGGGTGTGA AGTGGAAGCC 
ACTGTGGGAG AAGTTGTTAC AAATACATGG CTGGTTACTT GCATAGACTA TCAGACTTTG 
TTTGATCCAA AGTCGAATCC TCTCTTCACA CCAGTTCCAG TAATGACAGG AATGACTCCT 
TTAGAGGATT GTGTTATTTC ATTTAGCCAG TGTGCTGGAG CAGAAAAAGA GTCTTTAACA 
TTCCTAGCAA ACCTCCTTGG AGCAAGTGTT CAAGAATACT TTGTTCGCAA ATCCAATGCA 
AAGAAAGGCA TGTTTGCCAG TACTCATCTT ATACTGAAAG AACGTGGTGG CTCTAAATAT 
GAAGCTGCAA AGAAGTGGAA TTTACCTGCC GTTACTATAG CTTGGCTGTT GGAGACTGCT 
AGAACGGGAA AGAGAGCAGA CGAAAGCCAT TTTCTGATTG AAAATTCAAC TAAAGAAGAA 
CGAAGTTTGG AAACAGAAAT AACAAATGGA ATCAATCTAA ATTCAGATAC TGCAGAGCAT 
CCTGGCACAC GCCTGCAAAC TCACAGAAAA ACCGTCGTTA CACCTTTAGA TATGAACCGC 
TTTCAGAGTA AAGCTTTCCG TGCTGTGGTC TCACAACATG CCAGACAGGT CGCAGCCTCC 
CCAGCAGTAG GACAACCACT TCAGAAGGAG CCCTCGTTAC ACCTGGATAC ACCATCAAAA 
TTCCTGTCCA AGGACAAACT CTTCAAGCCT TCCTTTGATG TGAAGGATGC ACTTGCAGCC 
TTGGAAACTC CAGGACGTCC CAGCCAACAG AAAAGGAAAC CGAGTACGCC ACTCTCAGAA 
GTTATTGTCA AAAACTTGCA ACTTGCTTTG GCAAATAGCT CTCGAAATGC TGTCGCTCTT 
TCTGCCAGCC CTCAACTGAA AGAGGCCCAG TCAGAGAAGG AAGAAGCCCC AAAGCCACTT 
CACAAAGTAG TGGTATGTGT TAGTAAAAAA CTCAGTAAGA AGCAGAGTGA ACTAAATGGG 
ATCGCAGCCT CTCTAGGAGC AGATTACAGG TGGAGTTTTG ATGAAACAGT GACTCATTTC 
ATCTATCAAG GGCGGCCAAA TGACACTAAT CGGGAGTATA AATCTGTAAA AGAAAGAGGA 
GTACACATTG TTTCCGAGCA CTGGCTTTTA GATTGTGCCC AAGAGTGTAA ACATCTTCCT 
GAATCTCTTT ATCCACATAC TTATAATCCC AAAATGAGCT TGGATATCAG CGCAGTGCAA 
GATGGCCGGC TCTGTAATAG TCGACTACTC TCAGCTGTGT CTTCAACAAA GGATGATGAG 
CCAGATCCTT TGATTTTAGA AGAAAATGAT GTAGACAATA TGGCCACCAA TAATAAAGAG 
TCAGCACCAT CAAATGGAAG TGGAAAGAAT GACTCTAAAG GAGTTCTGAC ACAGACCTTA 
GAGATGAGAG AGAACTTTCA GAAGCAGTTA CAGGAGATAA TGTCTGCAAC ATCAATAGTG 
AAACCCCAAG GGCAGAGGAC TTCCCTTTCA AGAAGTGGTT GTAACAGCGC ATCTTCAACC 
CCTGACAGCA CTCGCTCTGC TCGCAGTGGA CGAAGTAGAG TCCTAGAGGC ACTGAGGCAG 
TCTCGTCAGA CAGTACCTGA TGTCAACACA GAGCCTTCCC AAAATGAACA GATCATTTGG 
GATGACCCTA CAGCAAGGGA GGAGAGAGCA AGGCTTGCCA GCAATTTGCA GTGGCCTAGT 
TGTCCCACAC AATACTCTGA GCTTCAGGTT GACATTCAAA ACTTGGAGGA TTCTCCTTTT 
CAAAAGCCTT TACATGATTC AGAAATTGCT AAACAGGCTG TCTGTGATCC TGGAAACATA 
CGTGTGACTG AAGCTCCCAA ACACCCAATC TCTGAAGAAC TGGAAACTCC CATAAAAGAC 
AGCCACCTGA TCCCTACGCC TCAAGCCCCC AGTATTGCCT TTCCACTCGC CAACCCCCCT 
GTGGCTCCGC ACCCTAGAGA AAAGATTATA ACGATAGAGG AGACTCATGA AGAATTAAAA 
AAACAGTACA TATTTCAGTT ATCATCTCTG AATCCTCAAG AACGTATTGA CTATTGTCAT 
CTGATTGAGA AACTAGGTGG ATTGGTGATA GAAAAGCAGT GCTTTGATCC CACCTGTACA 
CACATTGTTG TGGGACATCC ACTTCGAAAC GAGAAGTATT TAGCCTCAGT GGCAGCTGGG 
AAGTGGGTGC TTCATCGCTC CTACCTTGAA GCCTGCAGGA CTGCTGGACA CTTCGTGCAG 
GAAGAAGACT ATGAATGGGG AAGTAGTTCC ATACTTGATG TTCTGACTGG AATCAATGTA 
CAGCAACGAA GACTAGCACT TGCAGCAATG AGATGGAGAA AAAAAATCCA GCAAAGACAA 
GAATCTGGCA TTGTTGAGGG AGCATTTAGT GGGTGGAAGG TTATTTTACA TGTGGATCAG 
TCTCGAGAAG CAGGCTTCAA ACGCCTTCTT CAGTCAGGAG GAGCAAAGGT GCTACCTGGT 
CATTCTGTAC CTTTATTTAA AGAGGCCACA CATCTTTTTT CTGACTTGAA TAAACTGAAA 
CCAGATGACT CAGGAGTTAA TATAGCAGAA GCTGCTGCCC AGAACGTGTA CTGCTTGAGA 
ACAGAATACA TTGCTGATTA TCTCATGCAG GAATCACCTC CTCATGTAGA AAATTACTGT 
CTACCAGAAG CTATTTCATT TATTCAGAAT AATAAGGAAC TTGGGACTGG ATTATCACAA 
AAGAGGAAAG CTCCTACAGA AAAAAATAAA ATCAAACGAC CTAGAGTACA CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_005247133.1
CDS	620..5173
Translation	MSRNDKEPFFVKFLKSSDNSKCFFKALESIKEFQSEEYLQIITEEEALKIKENDRSLYICDPFSGVVFDHLKKLGCRIVGPQVVIFCMHHQRCVPRAEHPVYNMVMSDVTISCTSLEKEKREEVHKYVQMMGGRVYRDLNVSVTHLIAGEVGSKKYLVAANLKKPILLPSWIKTLWEKSQEKKITRYTDINMEDFKCPIFLGCIICVTGLCGLDRKEVQQLTVKHGGQYMGQLKMNECTHLIVQEPKGQKYECAKRWNVHCVTTQWFFDSIEKGFCQDESIYKTEPRPEAKTMPNSSTPTSQINTIDNVSNISNINASCVSESICNSLNSKLEPTLENLENLDVSAFQAPEDLLDGCRIYLCGFSGRKLDKLRRLINSGGGVRFNQLNEDVTHVIVGDYDDELKQFWNKSAHRPHVVGAKWLLECFSKGYMLSEEPYIHANYQPVEIPVSHKPESKAALLKKKNSSFSKKDFAPSEKHEQADEDLLSQYENGSSTVVEAKTSEARPFNDSTHAEPLNDSTHISLQEENQSSVSHCVPDVSTITEEGLFSQKSFLVLGFSNENESNIANIIKENAGKIMSLLSRTVADYAVVPLLGCEVEATVGEVVTNTWLVTCIDYQTLFDPKSNPLFTPVPVMTGMTPLEDCVISFSQCAGAEKESLTFLANLLGASVQEYFVRKSNAKKGMFASTHLILKERGGSKYEAAKKWNLPAVTIAWLLETARTGKRADESHFLIENSTKEERSLETEITNGINLNSDTAEHPGTRLQTHRKTVVTPLDMNRFQSKAFRAVVSQHARQVAASPAVGQPLQKEPSLHLDTPSKFLSKDKLFKPSFDVKDALAALETPGRPSQQKRKPSTPLSEVIVKNLQLALANSSRNAVALSASPQLKEAQSEKEEAPKPLHKVVVCVSKKLSKKQSELNGIAASLGADYRWSFDETVTHFIYQGRPNDTNREYKSVKERGVHIVSEHWLLDCAQECKHLPESLYPHTYNPKMSLDISAVQDGRLCNSRLLSAVSSTKDDEPDPLILEENDVDNMATNNKESAPSNGSGKNDSKGVLTQTLEMRENFQKQLQEIMSATSIVKPQGQRTSLSRSGCNSASSTPDSTRSARSGRSRVLEALRQSRQTVPDVNTEPSQNEQIIWDDPTAREERARLASNLQWPSCPTQYSELQVDIQNLEDSPFQKPLHDSEIAKQAVCDPGNIRVTEAPKHPISEELETPIKDSHLIPTPQAPSIAFPLANPPVAPHPREKIITIEETHEELKKQYIFQLSSLNPQERIDYCHLIEKLGGLVIEKQCFDPTCTHIVVGHPLRNEKYLASVAAGKWVLHRSYLEACRTAGHFVQEEDYEWGSSSILDVLTGINVQQRRLALAAMRWRKKIQQRQESGIVEGAFSGWKVILHVDQSREAGFKRLLQSGGAKVLPGHSVPLFKEATHLFSDLNKLKPDDSGVNIAEAAAQNVYCLRTEYIADYLMQESPPHVENYCLPEAISFIQNNKELGTGLSQKRKAPTEKNKIKRPRVH

Target ORF information:

RefSeq Version	XM_005247076.3
Organism	Homo sapiens(human)
Definition	Homo sapiens topoisomerase (DNA) II binding protein 1 (TOPBP1), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_005247076.3

ORF Insert Sequence:

ATGTCCAGAA ATGACAAAGA ACCGTTTTTT GTGAAGTTTT TAAAGTCTTC AGACAATTCC 
AAATGTTTTT TTAAAGCTCT CGAGTCCATA AAAGAATTCC AATCAGAAGA ATATCTTCAG 
ATTATTACAG AAGAAGAGGC ATTGAAGATA AAGGAGAATG ATAGATCACT TTATATCTGT 
GACCCTTTTA GTGGCGTTGT CTTTGATCAC CTCAAAAAGC TTGGCTGCAG AATTGTTGGT 
CCTCAAGTAG TCATATTTTG TATGCACCAC CAGCGATGTG TCCCAAGAGC CGAACATCCA 
GTTTATAATA TGGTTATGTC TGATGTAACC ATATCTTGTA CAAGTCTGGA AAAAGAAAAA 
AGGGAAGAAG TTCATAAATA TGTACAAATG ATGGGCGGAC GAGTATACAG AGACCTTAAT 
GTATCAGTAA CTCACCTTAT TGCAGGAGAA GTTGGTAGCA AAAAATATTT AGTTGCTGCA 
AACCTGAAGA AACCTATTTT GCTTCCCTCT TGGATAAAAA CACTTTGGGA GAAGTCACAA 
GAGAAAAAAA TAACTAGATA TACTGATATA AACATGGAAG ATTTCAAGTG TCCTATTTTT 
CTTGGTTGCA TAATCTGTGT GACTGGCTTA TGTGGCTTAG ACAGGAAAGA AGTTCAGCAA 
CTCACAGTTA AGCATGGAGG TCAATACATG GGACAATTGA AAATGAATGA ATGTACACAC 
CTCATTGTGC AAGAACCAAA AGGTCAGAAG TATGAGTGTG CCAAGAGATG GAATGTACAC 
TGTGTGACCA CACAGTGGTT TTTTGACAGT ATTGAGAAAG GTTTTTGTCA GGATGAATCC 
ATATACAAGA CAGAACCTAG ACCAGAAGCA AAGACTATGC CCAATTCTTC AACTCCTACC 
AGCCAGATCA ACACAATTGA TAATGTCAGC AATATTTCCA ACATAAATGC AAGTTGCGTA 
AGTGAATCAA TATGTAATTC ACTTAACAGC AAACTGGAGC CTACACTTGA AAATCTAGAA 
AATCTGGATG TCAGTGCATT TCAAGCACCT GAAGATTTAT TAGATGGTTG TCGGATATAT 
CTTTGCGGTT TTAGTGGCAG AAAGCTAGAT AAACTGAGAA GACTTATTAA CAGTGGAGGT 
GGAGTTCGTT TTAACCAGCT AAATGAAGAT GTAACTCATG TTATTGTGGG AGATTATGAT 
GATGAATTGA AGCAGTTTTG GAATAAATCA GCCCACAGGC CTCATGTAGT GGGAGCAAAG 
TGGTTGCTAG AGTGTTTCAG TAAAGGTTAT ATGCTTTCTG AAGAACCATA TATCCATGCT 
AATTACCAGC CAGTGGAAAT TCCAGTTTCA CATAAGCCTG AAAGTAAAGC AGCTCTTTTA 
AAAAAGAAGA ACAGCAGCTT CTCTAAGAAA GACTTTGCTC CTAGTGAAAA GCATGAGCAA 
GCTGATGAAG ATCTGCTCTC TCAATATGAA AATGGTAGCT CCACAGTAGT TGAGGCTAAG 
ACGTCTGAAG CCAGGCCCTT TAATGATTCT ACTCATGCTG AGCCCTTGAA TGATTCTACT 
CACATTTCTT TGCAAGAAGA AAACCAGTCT TCTGTCAGTC ATTGTGTCCC TGATGTTTCT 
ACAATTACTG AAGAAGGCTT ATTTAGCCAA AAGAGTTTCC TTGTTTTGGG TTTTAGTAAT 
GAAAATGAAT CTAACATCGC AAACATCATA AAAGAAAATG CTGGGAAAAT CATGTCCCTT 
CTGAGCAGAA CTGTTGCGGA TTATGCTGTG GTTCCTCTGC TGGGGTGTGA AGTGGAAGCC 
ACTGTGGGAG AAGTTGTTAC AAATACATGG CTGGTTACTT GCATAGACTA TCAGACTTTG 
TTTGATCCAA AGTCGAATCC TCTCTTCACA CCAGTTCCAG TAATGACAGG AATGACTCCT 
TTAGAGGATT GTGTTATTTC ATTTAGCCAG TGTGCTGGAG CAGAAAAAGA GTCTTTAACA 
TTCCTAGCAA ACCTCCTTGG AGCAAGTGTT CAAGAATACT TTGTTCGCAA ATCCAATGCA 
AAGAAAGGCA TGTTTGCCAG TACTCATCTT ATACTGAAAG AACGTGGTGG CTCTAAATAT 
GAAGCTGCAA AGAAGTGGAA TTTACCTGCC GTTACTATAG CTTGGCTGTT GGAGACTGCT 
AGAACGGGAA AGAGAGCAGA CGAAAGCCAT TTTCTGATTG AAAATTCAAC TAAAGAAGAA 
CGAAGTTTGG AAACAGAAAT AACAAATGGA ATCAATCTAA ATTCAGATAC TGCAGAGCAT 
CCTGGCACAC GCCTGCAAAC TCACAGAAAA ACCGTCGTTA CACCTTTAGA TATGAACCGC 
TTTCAGAGTA AAGCTTTCCG TGCTGTGGTC TCACAACATG CCAGACAGGT CGCAGCCTCC 
CCAGCAGTAG GACAACCACT TCAGAAGGAG CCCTCGTTAC ACCTGGATAC ACCATCAAAA 
TTCCTGTCCA AGGACAAACT CTTCAAGCCT TCCTTTGATG TGAAGGATGC ACTTGCAGCC 
TTGGAAACTC CAGGACGTCC CAGCCAACAG AAAAGGAAAC CGAGTACGCC ACTCTCAGAA 
GTTATTGTCA AAAACTTGCA ACTTGCTTTG GCAAATAGCT CTCGAAATGC TGTCGCTCTT 
TCTGCCAGCC CTCAACTGAA AGAGGCCCAG TCAGAGAAGG AAGAAGCCCC AAAGCCACTT 
CACAAAGTAG TGGTATGTGT TAGTAAAAAA CTCAGTAAGA AGCAGAGTGA ACTAAATGGG 
ATCGCAGCCT CTCTAGGAGC AGATTACAGG TGGAGTTTTG ATGAAACAGT GACTCATTTC 
ATCTATCAAG GGCGGCCAAA TGACACTAAT CGGGAGTATA AATCTGTAAA AGAAAGAGGA 
GTACACATTG TTTCCGAGCA CTGGCTTTTA GATTGTGCCC AAGAGTGTAA ACATCTTCCT 
GAATCTCTTT ATCCACATAC TTATAATCCC AAAATGAGCT TGGATATCAG CGCAGTGCAA 
GATGGCCGGC TCTGTAATAG TCGACTACTC TCAGCTGTGT CTTCAACAAA GGATGATGAG 
CCAGATCCTT TGATTTTAGA AGAAAATGAT GTAGACAATA TGGCCACCAA TAATAAAGAG 
TCAGCACCAT CAAATGGAAG TGGAAAGAAT GACTCTAAAG GAGTTCTGAC ACAGACCTTA 
GAGATGAGAG AGAACTTTCA GAAGCAGTTA CAGGAGATAA TGTCTGCAAC ATCAATAGTG 
AAACCCCAAG GGCAGAGGAC TTCCCTTTCA AGAAGTGGTT GTAACAGCGC ATCTTCAACC 
CCTGACAGCA CTCGCTCTGC TCGCAGTGGA CGAAGTAGAG TCCTAGAGGC ACTGAGGCAG 
TCTCGTCAGA CAGTACCTGA TGTCAACACA GAGCCTTCCC AAAATGAACA GATCATTTGG 
GATGACCCTA CAGCAAGGGA GGAGAGAGCA AGGCTTGCCA GCAATTTGCA GTGGCCTAGT 
TGTCCCACAC AATACTCTGA GCTTCAGGTT GACATTCAAA ACTTGGAGGA TTCTCCTTTT 
CAAAAGCCTT TACATGATTC AGAAATTGCT AAACAGGCTG TCTGTGATCC TGGAAACATA 
CGTGTGACTG AAGCTCCCAA ACACCCAATC TCTGAAGAAC TGGAAACTCC CATAAAAGAC 
AGCCACCTGA TCCCTACGCC TCAAGCCCCC AGTATTGCCT TTCCACTCGC CAACCCCCCT 
GTGGCTCCGC ACCCTAGAGA AAAGATTATA ACGATAGAGG AGACTCATGA AGAATTAAAA 
AAACAGTACA TATTTCAGTT ATCATCTCTG AATCCTCAAG AACGTATTGA CTATTGTCAT 
CTGATTGAGA AACTAGGTGG ATTGGTGATA GAAAAGCAGT GCTTTGATCC CACCTGTACA 
CACATTGTTG TGGGACATCC ACTTCGAAAC GAGAAGTATT TAGCCTCAGT GGCAGCTGGG 
AAGTGGGTGC TTCATCGCTC CTACCTTGAA GCCTGCAGGA CTGCTGGACA CTTCGTGCAG 
GAAGAAGACT ATGAATGGGG AAGTAGTTCC ATACTTGATG TTCTGACTGG AATCAATGTA 
CAGCAACGAA GACTAGCACT TGCAGCAATG AGATGGAGAA AAAAAATCCA GCAAAGACAA 
GAATCTGGCA TTGTTGAGGG AGCATTTAGT GGGTGGAAGG TTATTTTACA TGTGGATCAG 
TCTCGAGAAG CAGGCTTCAA ACGCCTTCTT CAGTCAGGAG GAGCAAAGGT GCTACCTGGT 
CATTCTGTAC CTTTATTTAA AGAGGCCACA CATCTTTTTT CTGACTTGAA TAAACTGAAA 
CCAGATGACT CAGGAGTTAA TATAGCAGAA GCTGCTGCCC AGAACGTGTA CTGCTTGAGA 
ACAGAATACA TTGCTGATTA TCTCATGCAG GAATCACCTC CTCATGTAGA AAATTACTGT 
CTACCAGAAG CTATTTCATT TATTCAGAAT AATAAGGAAC TTGGGACTGG ATTATCACAA 
AAGAGGAAAG CTCCTACAGA AAAAAATAAA ATCAAACGAC CTAGAGTACA CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Gene Symbol	TOPBP1
Entrez Gene ID	11073
Full Name	DNA topoisomerase II binding protein 1
Synonyms	TOP2BP1
General protein information	Preferred Names DNA topoisomerase II binding protein 1 Names DNA topoisomerase 2-binding protein 1 DNA topoisomerase II-beta-binding protein 1 topoisomerase (DNA) II binding protein 1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 3 Map Location: 3q22.1
Summary	This gene encodes a binding protein which interacts with the C-terminal region of topoisomerase II beta. This interaction suggests a supportive role for this protein in the catalytic reactions of topoisomerase II beta through transient breakages of DNA strands. [provided by RefSeq, Jul 2008].
Disorder MIM:	607760

Bos taurus (cattle)	TOPBP1	NP_001193695.1
Rattus norvegicus (Norway rat)	Topbp1	XP_236578.6
Homo sapiens (human)	TOPBP1	NP_008958.2
Danio rerio (zebrafish)	topbp1	NP_001186667.1
Xenopus tropicalis (tropical clawed frog)	topbp1	XP_004915426.1
	TOPBP1	XP_001112636.2
Mus musculus (house mouse)	Topbp1	NP_795953.2
Gallus gallus (chicken)	TOPBP1	XP_418794.1
Pan troglodytes (chimpanzee)	TOPBP1	XP_516761.3
Canis lupus familiaris (dog)	TOPBP1	XP_005634503.1

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TOPBP1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

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