JTB cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	JTB
Entrez Gene ID	10899
Full Name	jumping translocation breakpoint
Synonyms	HJTB,HSPC222,PAR,hJT
General protein information	Preferred Names jumping translocation breakpoint Names protein JTB jumping translocation breakpoint protein prostate androgen-regulated protein
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 1 Map Location: 1q21.3
Disorder MIM:	604671

mRNA and Protein(s)

mRNA	Protein	Name
NM_006694.4	NP_006685.1	protein JTB precursor
NM_006694.3	NP_006685.1	protein JTB precursor

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Jtb	NP_062086.1
	LOC718537	XP_001111373.2
Mus musculus (house mouse)	Jtb	NP_996807.1
Homo sapiens (human)	JTB	NP_006685.1
Pan troglodytes (chimpanzee)	JTB	XP_001149478.1
Canis lupus familiaris (dog)	JTB	XP_855136.1
Bos taurus (cattle)	JTB	NP_001093830.1

Gene Ontology
Bibliography

Related articles in PubMed

Jumping translocations in myelodysplastic syndromes.
Yeung CCS, Deeg HJ, Pritchard C, Wu D, Fang M
Cancer genetics209(9)395-402(2016 Sep)

[Downregulation of PAR expression induces the apoptosis of human prostate cancer PC3 cells and increases the Bcl-2/Bax ratio].
Xu XF, Zhou XM, Wei ZF, Zhang ZY, Ge JP, Wei W, Zhou WQ, Cheng W, Hou JQ, Gao JP
Zhonghua nan ke xue = National journal of andrology18(10)896-9(2012 Oct)

HBsAg inhibits the translocation of JTB into mitochondria in HepG2 cells and potentially plays a role in HCC progression.
Liu YP, Yang XN, Jazag A, Pan JS, Hu TH, Liu JJ, Guleng B, Ren JL
PloS one7(5)e36914(2012)

The structure of the extracellular domain of the jumping translocation breakpoint protein reveals a variation of the midkine fold.
Rousseau F, Pan B, Fairbrother WJ, Bazan JF, Lingel A
Journal of molecular biology415(1)22-8(2012 Jan)

PAR, a protein involved in the cell cycle, is functionally related to chromosomal passenger proteins.
Platica M, Ionescu A, Ivan E, Holland JF, Mandeli J, Platica O
International journal of oncology38(3)777-85(2011 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Downregulation of the PAR expression increases the Bax/Bcl-2 ratio and Bax expression, and thus induces the G2-M phase arrest and apoptosis of PC3 cells.
Title: [Downregulation of PAR expression induces the apoptosis of human prostate cancer PC3 cells and increases the Bcl-2/Bax ratio].

Silencing of the JTB resulted in an increase in the phosphorylation of p65 in HepG2 cells.
Title: HBsAg inhibits the translocation of JTB into mitochondria in HepG2 cells and potentially plays a role in HCC progression.

The JTB structure has a distant relationship to the midkine/pleiotrophin fold, particularly in the conservation of distinctive disulfide bridge patterns.
Title: The structure of the extracellular domain of the jumping translocation breakpoint protein reveals a variation of the midkine fold.

Due to its involvement in cell cycle and its overexpression in several human cancers PAR could represent an attractive target for therapeutic intervention.
Title: PAR, a protein involved in the cell cycle, is functionally related to chromosomal passenger proteins.

Overexpression of JTB conferred resistance to apoptosis induced by ultraviolet radiation
Title: Interacting with HBsAg compromises resistance of jumping translocation breakpoint protein to ultraviolet radiation-induced apoptosis in 293FT cells.

The following JTB gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the JTB cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu12568	NM_006694.4 Latest version!	Homo sapiens jumping translocation breakpoint (JTB), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu12568	NM_006694.3	Homo sapiens jumping translocation breakpoint (JTB), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

JTB ( NM_006694.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_006685.1 Homo sapiens jumping translocation breakpoint (JTB), mRNA.

Price & Availability↑

CloneID	OHu12568
Clone ID Related Accession (Same CDS sequence)	NM_006694.4 , NM_006694.3
Accession Version	NM_006694.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 441bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Homo sapiens(human)
Product	protein JTB precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AL358472.54. On Nov 23, 2018 this sequence version replaced NM_006694.3. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: SRR3476690.928683.1, SRR3476690.1070256.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2467146 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000271843.9/ ENSP00000271843.4 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGCTTGCGG GTGCCGGGAG GCCTGGCCTC CCCCAGGGCC GCCACCTCTG CTGGTTGCTC 
TGTGCTTTCA CCTTAAAGCT CTGCCAAGCA GAGGCTCCCG TGCAGGAAGA GAAGCTGTCA 
GCAAGCACCT CAAATTTGCC ATGCTGGCTG GTGGAAGAGT TTGTGGTAGC AGAAGAGTGC 
TCTCCATGCT CTAATTTCCG GGCTAAAACT ACCCCTGAGT GTGGTCCCAC AGGATATGTA 
GAGAAAATCA CATGCAGCTC ATCTAAGAGA AATGAGTTCA AAAGCTGCCG CTCAGCTTTG 
ATGGAACAAC GCTTATTTTG GAAGTTCGAA GGGGCTGTCG TGTGTGTGGC CCTGATCTTC 
GCTTGTCTTG TCATCATTCG TCAGCGACAA TTGGACAGAA AGGCTCTGGA AAAGGTCCGG 
AAGCAAATCG AGTCCATATA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006685.1
CDS	423..863
Translation	MLAGAGRPGLPQGRHLCWLLCAFTLKLCQAEAPVQEEKLSASTSNLPCWLVEEFVVAEECSPCSNFRAKTTPECGPTGYVEKITCSSSKRNEFKSCRSALMEQRLFWKFEGAVVCVALIFACLVIIRQRQLDRKALEKVRKQIESI

Target ORF information:

RefSeq Version	NM_006694.4
Organism	Homo sapiens(human)
Definition	Homo sapiens jumping translocation breakpoint (JTB), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006694.4

ORF Insert Sequence:

ATGCTTGCGG GTGCCGGGAG GCCTGGCCTC CCCCAGGGCC GCCACCTCTG CTGGTTGCTC 
TGTGCTTTCA CCTTAAAGCT CTGCCAAGCA GAGGCTCCCG TGCAGGAAGA GAAGCTGTCA 
GCAAGCACCT CAAATTTGCC ATGCTGGCTG GTGGAAGAGT TTGTGGTAGC AGAAGAGTGC 
TCTCCATGCT CTAATTTCCG GGCTAAAACT ACCCCTGAGT GTGGTCCCAC AGGATATGTA 
GAGAAAATCA CATGCAGCTC ATCTAAGAGA AATGAGTTCA AAAGCTGCCG CTCAGCTTTG 
ATGGAACAAC GCTTATTTTG GAAGTTCGAA GGGGCTGTCG TGTGTGTGGC CCTGATCTTC 
GCTTGTCTTG TCATCATTCG TCAGCGACAA TTGGACAGAA AGGCTCTGGA AAAGGTCCGG 
AAGCAAATCG AGTCCATATA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

JTB ( NM_006694.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_006685.1 Homo sapiens jumping translocation breakpoint (JTB), mRNA.

Price & Availability↑

CloneID	OHu12568
Clone ID Related Accession (Same CDS sequence)	NM_006694.4 , NM_006694.3
Accession Version	NM_006694.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 441bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	protein JTB precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AL358472.54. On Aug 16, 2007 this sequence version replaced NM_006694.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: SRR1163655.163706.1, SRR1163657.424806.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2467146 [ECO:0000348] ##Evidence-Data-END##

ATGCTTGCGG GTGCCGGGAG GCCTGGCCTC CCCCAGGGCC GCCACCTCTG CTGGTTGCTC 
TGTGCTTTCA CCTTAAAGCT CTGCCAAGCA GAGGCTCCCG TGCAGGAAGA GAAGCTGTCA 
GCAAGCACCT CAAATTTGCC ATGCTGGCTG GTGGAAGAGT TTGTGGTAGC AGAAGAGTGC 
TCTCCATGCT CTAATTTCCG GGCTAAAACT ACCCCTGAGT GTGGTCCCAC AGGATATGTA 
GAGAAAATCA CATGCAGCTC ATCTAAGAGA AATGAGTTCA AAAGCTGCCG CTCAGCTTTG 
ATGGAACAAC GCTTATTTTG GAAGTTCGAA GGGGCTGTCG TGTGTGTGGC CCTGATCTTC 
GCTTGTCTTG TCATCATTCG TCAGCGACAA TTGGACAGAA AGGCTCTGGA AAAGGTCCGG 
AAGCAAATCG AGTCCATATA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006685.1
CDS	724..1164
Translation	MLAGAGRPGLPQGRHLCWLLCAFTLKLCQAEAPVQEEKLSASTSNLPCWLVEEFVVAEECSPCSNFRAKTTPECGPTGYVEKITCSSSKRNEFKSCRSALMEQRLFWKFEGAVVCVALIFACLVIIRQRQLDRKALEKVRKQIESI

Target ORF information:

RefSeq Version	NM_006694.3
Organism	Homo sapiens(human)
Definition	Homo sapiens jumping translocation breakpoint (JTB), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006694.3

ORF Insert Sequence:

ATGCTTGCGG GTGCCGGGAG GCCTGGCCTC CCCCAGGGCC GCCACCTCTG CTGGTTGCTC 
TGTGCTTTCA CCTTAAAGCT CTGCCAAGCA GAGGCTCCCG TGCAGGAAGA GAAGCTGTCA 
GCAAGCACCT CAAATTTGCC ATGCTGGCTG GTGGAAGAGT TTGTGGTAGC AGAAGAGTGC 
TCTCCATGCT CTAATTTCCG GGCTAAAACT ACCCCTGAGT GTGGTCCCAC AGGATATGTA 
GAGAAAATCA CATGCAGCTC ATCTAAGAGA AATGAGTTCA AAAGCTGCCG CTCAGCTTTG 
ATGGAACAAC GCTTATTTTG GAAGTTCGAA GGGGCTGTCG TGTGTGTGGC CCTGATCTTC 
GCTTGTCTTG TCATCATTCG TCAGCGACAA TTGGACAGAA AGGCTCTGGA AAAGGTCCGG 
AAGCAAATCG AGTCCATATA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Jumping translocations in myelodysplastic syndromes.
Cancer genetics209(9)395-402(2016 Sep)
Yeung CCS,Deeg HJ,Pritchard C,Wu D,Fang M

[Downregulation of PAR expression induces the apoptosis of human prostate cancer PC3 cells and increases the Bcl-2/Bax ratio].
Zhonghua nan ke xue = National journal of andrology18(10)896-9(2012 Oct)
Xu XF,Zhou XM,Wei ZF,Zhang ZY,Ge JP,Wei W,Zhou WQ,Cheng W,Hou JQ,Gao JP

HBsAg inhibits the translocation of JTB into mitochondria in HepG2 cells and potentially plays a role in HCC progression.
PloS one7(5)e36914(2012)
Liu YP,Yang XN,Jazag A,Pan JS,Hu TH,Liu JJ,Guleng B,Ren JL

The structure of the extracellular domain of the jumping translocation breakpoint protein reveals a variation of the midkine fold.
Journal of molecular biology415(1)22-8(2012 Jan)
Rousseau F,Pan B,Fairbrother WJ,Bazan JF,Lingel A

PAR, a protein involved in the cell cycle, is functionally related to chromosomal passenger proteins.
International journal of oncology38(3)777-85(2011 Mar)
Platica M,Ionescu A,Ivan E,Holland JF,Mandeli J,Platica O