EMC8 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	EMC8
Entrez Gene ID	10328
Full Name	ER membrane protein complex subunit 8
Synonyms	C16orf2,C16orf4,COX4NB,FAM158B,NOC4
General protein information	Preferred Names ER membrane protein complex subunit 8 Names ER membrane protein complex subunit 8 COX4 neighbor family with sequence similarity 158, member B neighbor of COX4
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 16 Map Location: 16q24.1
Disorder MIM:	604886

mRNA and Protein(s)

mRNA	Protein	Name
NM_006067.4	NP_006058.1	ER membrane protein complex subunit 8 isoform 1
XM_011522813.3	XP_011521115.1	ER membrane protein complex subunit 8 isoform X2
XM_011522813.2	XP_011521115.1	ER membrane protein complex subunit 8 isoform X2
NM_001142288.1	NP_001135760.1	ER membrane protein complex subunit 8 isoform 2
NM_001142288.2	NP_001135760.1	ER membrane protein complex subunit 8 isoform 2
XM_017022867.1	XP_016878356.1	ER membrane protein complex subunit 8 isoform X1
NM_006067.5	NP_006058.1	ER membrane protein complex subunit 8 isoform 1

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	EMC8	XP_536760.2
Mus musculus (house mouse)	Emc8	NP_035056.1
Rattus norvegicus (Norway rat)	Emc8	NP_001012165.1
Gallus gallus (chicken)	EMC8	XP_414188.1
Oryza sativa (rice)	Os04g0270200	NP_001052342.1
Xenopus tropicalis (tropical clawed frog)	emc8	NP_989181.1
Pan troglodytes (chimpanzee)	COX4NB	XP_001153950.1
	COX4NB	XP_001083258.1
Bos taurus (cattle)	EMC8	NP_001033163.1
Homo sapiens (human)	EMC8	NP_006058.1
Danio rerio (zebrafish)	emc8	NP_998535.1
Arabidopsis thaliana (thale cress)	emb2731	NP_568832.1

Gene Ontology
Bibliography

Related articles in PubMed

Architecture of the human interactome defines protein communities and disease networks.
Huttlin EL, Bruckner RJ, Paulo JA, Cannon JR, Ting L, Baltier K, Colby G, Gebreab F, Gygi MP, Parzen H, Szpyt J, Tam S, Zarraga G, Pontano-Vaites L, Swarup S, White AE, Schweppe DK, Rad R, Erickson BK, Obar RA, Guruharsha KG, Li K, Artavanis-Tsakonas S, Gygi SP, Harper JW
Nature545(7655)505-509(2017 05)

A human interactome in three quantitative dimensions organized by stoichiometries and abundances.
Hein MY, Hubner NC, Poser I, Cox J, Nagaraj N, Toyoda Y, Gak IA, Weisswange I, Mansfeld J, Buchholz F, Hyman AA, Mann M
Cell163(3)712-23(2015 Oct)

Defining human ERAD networks through an integrative mapping strategy.
Christianson JC, Olzmann JA, Shaler TA, Sowa ME, Bennett EJ, Richter CM, Tyler RE, Greenblatt EJ, Harper JW, Kopito RR
Nature cell biology14(1)93-105(2011 Nov)

MicroRNA-related genetic variations as predictors for risk of second primary tumor and/or recurrence in patients with early-stage head and neck cancer.
Zhang X, Yang H, Lee JJ, Kim E, Lippman SM, Khuri FR, Spitz MR, Lotan R, Hong WK, Wu X
Carcinogenesis31(12)2118-23(2010 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
Title: MicroRNA-related genetic variations as predictors for risk of second primary tumor and/or recurrence in patients with early-stage head and neck cancer.

Observational study of gene-disease association. (HuGE Navigator)
Title: Association of genetic variants with hemorrhagic stroke in Japanese individuals.

Observational study of gene-disease association. (HuGE Navigator)
Title: Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals.

Observational study of gene-disease association. (HuGE Navigator)
Title: Association of gene polymorphisms with chronic kidney disease in Japanese individuals.

The following EMC8 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the EMC8 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu24473	NM_006067.5 Latest version!	Homo sapiens ER membrane protein complex subunit 8 (EMC8), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu24474	NM_001142288.2 Latest version!	Homo sapiens ER membrane protein complex subunit 8 (EMC8), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu63924	XM_011522813.3 Latest version!	Homo sapiens ER membrane protein complex subunit 8 (EMC8), transcript variant X3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OHu85813	XM_017022867.1 Latest version!	Homo sapiens ER membrane protein complex subunit 8 (EMC8), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
View Old Accession Versions >>
OHu63924	XM_011522813.2	Homo sapiens ER membrane protein complex subunit 8 (EMC8), transcript variant X3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OHu24474	NM_001142288.1	Homo sapiens ER membrane protein complex subunit 8 (EMC8), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu24473	NM_006067.4	Homo sapiens ER membrane protein complex subunit 8 (EMC8), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

EMC8 ( NM_006067.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_006058.1 Homo sapiens ER membrane protein complex subunit 8 (EMC8), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu24473
Clone ID Related Accession (Same CDS sequence)	NM_006067.4 , NM_006067.5
Accession Version	NM_006067.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 633bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	ER membrane protein complex subunit 8 isoform 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BP307869.1, BC020250.1 and AC018695.6. On Nov 25, 2008 this sequence version replaced NM_006067.3. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments. ##Evidence-Data-START## Transcript exon combination :: SRR1163655.404517.1, SRR1660805.244445.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCCCGGGG TGAAACTGAC CACCCAGGCC TACTGCAAGA TGGTGCTGCA CGGCGCCAAG 
TACCCGCACT GCGCCGTCAA CGGGCTCCTG GTGGCCGAGA AGCAGAAGCC GCGTAAGGAG 
CACCTCCCCC TGGGCGGCCC CGGCGCCCAC CACACCCTCT TCGTGGACTG CATCCCCCTC 
TTCCACGGCA CCCTGGCCCT CGCCCCCATG CTGGAGGTGG CTCTCACCCT GATTGATTCA 
TGGTGCAAAG ATCATAGCTA CGTGATTGCT GGTTATTATC AAGCTAATGA GCGAGTAAAG 
GATGCCAGTC CAAACCAGGT TGCAGAGAAG GTGGCCTCCA GAATCGCCGA GGGCTTCAGC 
GACACTGCGC TCATCATGGT AGACAACACC AAGTTTACGA TGGACTGCGT AGCGCCTACG 
ATCCACGTGT ACGAGCACCA TGAGAACAGA TGGCGGTGCA GAGACCCACA CCATGACTAC 
TGTGAAGACT GGCCAGAGGC ACAGAGGATC TCAGCCTCGC TCCTGGACAG CCGGTCCTAC 
GAGACGCTCG TGGATTTCGA TAACCACCTG GATGACATTC GGAATGACTG GACAAACCCA 
GAGATCAATA AAGCTGTCCT ACACTTGTGC TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006058.1
CDS	248..880
Translation	MPGVKLTTQAYCKMVLHGAKYPHCAVNGLLVAEKQKPRKEHLPLGGPGAHHTLFVDCIPLFHGTLALAPMLEVALTLIDSWCKDHSYVIAGYYQANERVKDASPNQVAEKVASRIAEGFSDTALIMVDNTKFTMDCVAPTIHVYEHHENRWRCRDPHHDYCEDWPEAQRISASLLDSRSYETLVDFDNHLDDIRNDWTNPEINKAVLHLC

Target ORF information:

RefSeq Version	NM_006067.4
Organism	Homo sapiens(human)
Definition	Homo sapiens ER membrane protein complex subunit 8 (EMC8), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006067.4

ORF Insert Sequence:

ATGCCCGGGG TGAAACTGAC CACCCAGGCC TACTGCAAGA TGGTGCTGCA CGGCGCCAAG 
TACCCGCACT GCGCCGTCAA CGGGCTCCTG GTGGCCGAGA AGCAGAAGCC GCGTAAGGAG 
CACCTCCCCC TGGGCGGCCC CGGCGCCCAC CACACCCTCT TCGTGGACTG CATCCCCCTC 
TTCCACGGCA CCCTGGCCCT CGCCCCCATG CTGGAGGTGG CTCTCACCCT GATTGATTCA 
TGGTGCAAAG ATCATAGCTA CGTGATTGCT GGTTATTATC AAGCTAATGA GCGAGTAAAG 
GATGCCAGTC CAAACCAGGT TGCAGAGAAG GTGGCCTCCA GAATCGCCGA GGGCTTCAGC 
GACACTGCGC TCATCATGGT AGACAACACC AAGTTTACGA TGGACTGCGT AGCGCCTACG 
ATCCACGTGT ACGAGCACCA TGAGAACAGA TGGCGGTGCA GAGACCCACA CCATGACTAC 
TGTGAAGACT GGCCAGAGGC ACAGAGGATC TCAGCCTCGC TCCTGGACAG CCGGTCCTAC 
GAGACGCTCG TGGATTTCGA TAACCACCTG GATGACATTC GGAATGACTG GACAAACCCA 
GAGATCAATA AAGCTGTCCT ACACTTGTGC TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

EMC8 ( NM_006067.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_006058.1 Homo sapiens ER membrane protein complex subunit 8 (EMC8), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu24473
Clone ID Related Accession (Same CDS sequence)	NM_006067.4 , NM_006067.5
Accession Version	NM_006067.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 633bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-10
Organism	Homo sapiens(human)
Product	ER membrane protein complex subunit 8 isoform 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC018695.6, BP307869.1 and BC020250.1. On Nov 22, 2018 this sequence version replaced NM_006067.4. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments. ##Evidence-Data-START## Transcript exon combination :: SRR3476690.611781.1, SRR3476690.1098539.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000253457.8/ ENSP00000253457.3 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGCCCGGGG TGAAACTGAC CACCCAGGCC TACTGCAAGA TGGTGCTGCA CGGCGCCAAG 
TACCCGCACT GCGCCGTCAA CGGGCTCCTG GTGGCCGAGA AGCAGAAGCC GCGTAAGGAG 
CACCTCCCCC TGGGCGGCCC CGGCGCCCAC CACACCCTCT TCGTGGACTG CATCCCCCTC 
TTCCACGGCA CCCTGGCCCT CGCCCCCATG CTGGAGGTGG CTCTCACCCT GATTGATTCA 
TGGTGCAAAG ATCATAGCTA CGTGATTGCT GGTTATTATC AAGCTAATGA GCGAGTAAAG 
GATGCCAGTC CAAACCAGGT TGCAGAGAAG GTGGCCTCCA GAATCGCCGA GGGCTTCAGC 
GACACTGCGC TCATCATGGT AGACAACACC AAGTTTACGA TGGACTGCGT AGCGCCTACG 
ATCCACGTGT ACGAGCACCA TGAGAACAGA TGGCGGTGCA GAGACCCACA CCATGACTAC 
TGTGAAGACT GGCCAGAGGC ACAGAGGATC TCAGCCTCGC TCCTGGACAG CCGGTCCTAC 
GAGACGCTCG TGGATTTCGA TAACCACCTG GATGACATTC GGAATGACTG GACAAACCCA 
GAGATCAATA AAGCTGTCCT ACACTTGTGC TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006058.1
CDS	250..882
Translation	MPGVKLTTQAYCKMVLHGAKYPHCAVNGLLVAEKQKPRKEHLPLGGPGAHHTLFVDCIPLFHGTLALAPMLEVALTLIDSWCKDHSYVIAGYYQANERVKDASPNQVAEKVASRIAEGFSDTALIMVDNTKFTMDCVAPTIHVYEHHENRWRCRDPHHDYCEDWPEAQRISASLLDSRSYETLVDFDNHLDDIRNDWTNPEINKAVLHLC

Target ORF information:

RefSeq Version	NM_006067.5
Organism	Homo sapiens(human)
Definition	Homo sapiens ER membrane protein complex subunit 8 (EMC8), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006067.5

ORF Insert Sequence:

ATGCCCGGGG TGAAACTGAC CACCCAGGCC TACTGCAAGA TGGTGCTGCA CGGCGCCAAG 
TACCCGCACT GCGCCGTCAA CGGGCTCCTG GTGGCCGAGA AGCAGAAGCC GCGTAAGGAG 
CACCTCCCCC TGGGCGGCCC CGGCGCCCAC CACACCCTCT TCGTGGACTG CATCCCCCTC 
TTCCACGGCA CCCTGGCCCT CGCCCCCATG CTGGAGGTGG CTCTCACCCT GATTGATTCA 
TGGTGCAAAG ATCATAGCTA CGTGATTGCT GGTTATTATC AAGCTAATGA GCGAGTAAAG 
GATGCCAGTC CAAACCAGGT TGCAGAGAAG GTGGCCTCCA GAATCGCCGA GGGCTTCAGC 
GACACTGCGC TCATCATGGT AGACAACACC AAGTTTACGA TGGACTGCGT AGCGCCTACG 
ATCCACGTGT ACGAGCACCA TGAGAACAGA TGGCGGTGCA GAGACCCACA CCATGACTAC 
TGTGAAGACT GGCCAGAGGC ACAGAGGATC TCAGCCTCGC TCCTGGACAG CCGGTCCTAC 
GAGACGCTCG TGGATTTCGA TAACCACCTG GATGACATTC GGAATGACTG GACAAACCCA 
GAGATCAATA AAGCTGTCCT ACACTTGTGC TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

EMC8 ( NM_001142288.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001135760.1 Homo sapiens ER membrane protein complex subunit 8 (EMC8), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu24474
Clone ID Related Accession (Same CDS sequence)	NM_001142288.1 , NM_001142288.2
Accession Version	NM_001142288.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 381bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-02
Organism	Homo sapiens(human)
Product	ER membrane protein complex subunit 8 isoform 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BP307869.1, BE855452.1 and AC018695.6. Transcript Variant: This variant (2) lacks an alternate coding exon compared to variant 1, that causes a frameshift. The resulting isoform (2) has a shorter C-terminus compared to isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments. ##Evidence-Data-START## Transcript exon combination :: SRR1803611.156842.1, SRR1803616.140882.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2467146 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCCCGGGG TGAAACTGAC CACCCAGGCC TACTGCAAGA TGGTGCTGCA CGGCGCCAAG 
TACCCGCACT GCGCCGTCAA CGGGCTCCTG GTGGCCGAGA AGCAGAAGCC GCGTAAGGAG 
CACCTCCCCC TGGGCGGCCC CGGCGCCCAC CACACCCTCT TCGTGGACTG CATCCCCCTC 
TTCCACGGCA CCCTGGCCCT CGCCCCCATG CTGGAGGTGG CTCTCACCCT GATTGATTCA 
TGGTGCAAAG ATCATAGCTA CGTGATTGCT GGTTATTATC AAGCTAATGA GCGAGTAAAG 
GATGCCAGTC CAAACCAGGT TGCAGAGAAG GTGGCCTCCA GAATCGCCGA GGGCTTCAGC 
GACACTGCGC TCATCATGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001135760.1
CDS	248..628
Translation	MPGVKLTTQAYCKMVLHGAKYPHCAVNGLLVAEKQKPRKEHLPLGGPGAHHTLFVDCIPLFHGTLALAPMLEVALTLIDSWCKDHSYVIAGYYQANERVKDASPNQVAEKVASRIAEGFSDTALIM

Target ORF information:

RefSeq Version	NM_001142288.1
Organism	Homo sapiens(human)
Definition	Homo sapiens ER membrane protein complex subunit 8 (EMC8), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001142288.1

ORF Insert Sequence:

ATGCCCGGGG TGAAACTGAC CACCCAGGCC TACTGCAAGA TGGTGCTGCA CGGCGCCAAG 
TACCCGCACT GCGCCGTCAA CGGGCTCCTG GTGGCCGAGA AGCAGAAGCC GCGTAAGGAG 
CACCTCCCCC TGGGCGGCCC CGGCGCCCAC CACACCCTCT TCGTGGACTG CATCCCCCTC 
TTCCACGGCA CCCTGGCCCT CGCCCCCATG CTGGAGGTGG CTCTCACCCT GATTGATTCA 
TGGTGCAAAG ATCATAGCTA CGTGATTGCT GGTTATTATC AAGCTAATGA GCGAGTAAAG 
GATGCCAGTC CAAACCAGGT TGCAGAGAAG GTGGCCTCCA GAATCGCCGA GGGCTTCAGC 
GACACTGCGC TCATCATGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

EMC8 ( NM_001142288.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001135760.1 Homo sapiens ER membrane protein complex subunit 8 (EMC8), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu24474
Clone ID Related Accession (Same CDS sequence)	NM_001142288.1 , NM_001142288.2
Accession Version	NM_001142288.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 381bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-10
Organism	Homo sapiens(human)
Product	ER membrane protein complex subunit 8 isoform 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC018695.6, BP307869.1 and BE855452.1. On May 31, 2019 this sequence version replaced NM_001142288.1. Transcript Variant: This variant (2) lacks an alternate coding exon compared to variant 1, that causes a frameshift. The resulting isoform (2) has a shorter C-terminus compared to isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments. ##Evidence-Data-START## Transcript exon combination :: DRR138524.640512.1, DRR138506.60301.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2467146 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCCCGGGG TGAAACTGAC CACCCAGGCC TACTGCAAGA TGGTGCTGCA CGGCGCCAAG 
TACCCGCACT GCGCCGTCAA CGGGCTCCTG GTGGCCGAGA AGCAGAAGCC GCGTAAGGAG 
CACCTCCCCC TGGGCGGCCC CGGCGCCCAC CACACCCTCT TCGTGGACTG CATCCCCCTC 
TTCCACGGCA CCCTGGCCCT CGCCCCCATG CTGGAGGTGG CTCTCACCCT GATTGATTCA 
TGGTGCAAAG ATCATAGCTA CGTGATTGCT GGTTATTATC AAGCTAATGA GCGAGTAAAG 
GATGCCAGTC CAAACCAGGT TGCAGAGAAG GTGGCCTCCA GAATCGCCGA GGGCTTCAGC 
GACACTGCGC TCATCATGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001135760.1
CDS	250..630
Translation	MPGVKLTTQAYCKMVLHGAKYPHCAVNGLLVAEKQKPRKEHLPLGGPGAHHTLFVDCIPLFHGTLALAPMLEVALTLIDSWCKDHSYVIAGYYQANERVKDASPNQVAEKVASRIAEGFSDTALIM

Target ORF information:

RefSeq Version	NM_001142288.2
Organism	Homo sapiens(human)
Definition	Homo sapiens ER membrane protein complex subunit 8 (EMC8), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001142288.2

ORF Insert Sequence:

ATGCCCGGGG TGAAACTGAC CACCCAGGCC TACTGCAAGA TGGTGCTGCA CGGCGCCAAG 
TACCCGCACT GCGCCGTCAA CGGGCTCCTG GTGGCCGAGA AGCAGAAGCC GCGTAAGGAG 
CACCTCCCCC TGGGCGGCCC CGGCGCCCAC CACACCCTCT TCGTGGACTG CATCCCCCTC 
TTCCACGGCA CCCTGGCCCT CGCCCCCATG CTGGAGGTGG CTCTCACCCT GATTGATTCA 
TGGTGCAAAG ATCATAGCTA CGTGATTGCT GGTTATTATC AAGCTAATGA GCGAGTAAAG 
GATGCCAGTC CAAACCAGGT TGCAGAGAAG GTGGCCTCCA GAATCGCCGA GGGCTTCAGC 
GACACTGCGC TCATCATGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

EMC8 ( XM_011522813.3 ) cDNA ORF clone, Homo sapiens(human) -> XP_011521115.1 Homo sapiens ER membrane protein complex subunit 8 (EMC8), transcript variant X3, mRNA.

Price & Availability↑

CloneID	OHu63924
Clone ID Related Accession (Same CDS sequence)	XM_011522813.3 , XM_011522813.2
Accession Version	XM_011522813.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 441bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	ER membrane protein complex subunit 8 isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000016.10) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_011522813.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCCCGGGG TGAAACTGAC CACCCAGGCC TACTGCAAGA TGGTGCTGCA CGGCGCCAAG 
TACCCGCACT GCGCCGTCAA CGGGCTCCTG GTGGCCGAGA AGCAGAAGCC GCGTAAGGAG 
CACCTCCCCC TGGGCGGCCC CGGCGCCCAC CACACCCTCT TCGTGGACTG CATCCCCCTC 
TTCCACGGCA CCCTGGCCCT CGCCCCCATG CTGGAGGTGG CTCTCACCCT GATTGATTCA 
TGGTGCAAAG ATCATAGCTA CGTGATTGCT GGTTATTATC AAGCTAATGA GCGAGTAAAG 
GATGCCAGCA ATGCACAAGT GAAGAAACCA GCCGGAGAAG GTGGCTTCTC AGAGGCCACA 
CAGCTTGGGA GCTCAGGAGC TAGGATCATG CCAACTTCTG ACTTAAAAAT ATTGCCTCAT 
TCACAGTGTC TTGCAGCATG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011521115.1
CDS	261..701
Translation	MPGVKLTTQAYCKMVLHGAKYPHCAVNGLLVAEKQKPRKEHLPLGGPGAHHTLFVDCIPLFHGTLALAPMLEVALTLIDSWCKDHSYVIAGYYQANERVKDASNAQVKKPAGEGGFSEATQLGSSGARIMPTSDLKILPHSQCLAA

Target ORF information:

RefSeq Version	XM_011522813.3
Organism	Homo sapiens(human)
Definition	Homo sapiens ER membrane protein complex subunit 8 (EMC8), transcript variant X3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011522813.3

ORF Insert Sequence:

ATGCCCGGGG TGAAACTGAC CACCCAGGCC TACTGCAAGA TGGTGCTGCA CGGCGCCAAG 
TACCCGCACT GCGCCGTCAA CGGGCTCCTG GTGGCCGAGA AGCAGAAGCC GCGTAAGGAG 
CACCTCCCCC TGGGCGGCCC CGGCGCCCAC CACACCCTCT TCGTGGACTG CATCCCCCTC 
TTCCACGGCA CCCTGGCCCT CGCCCCCATG CTGGAGGTGG CTCTCACCCT GATTGATTCA 
TGGTGCAAAG ATCATAGCTA CGTGATTGCT GGTTATTATC AAGCTAATGA GCGAGTAAAG 
GATGCCAGCA ATGCACAAGT GAAGAAACCA GCCGGAGAAG GTGGCTTCTC AGAGGCCACA 
CAGCTTGGGA GCTCAGGAGC TAGGATCATG CCAACTTCTG ACTTAAAAAT ATTGCCTCAT 
TCACAGTGTC TTGCAGCATG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

EMC8 ( XM_011522813.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_011521115.1 Homo sapiens ER membrane protein complex subunit 8 (EMC8), transcript variant X3, mRNA.

Price & Availability↑

CloneID	OHu63924
Clone ID Related Accession (Same CDS sequence)	XM_011522813.3 , XM_011522813.2
Accession Version	XM_011522813.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 441bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-05
Organism	Homo sapiens(human)
Product	ER membrane protein complex subunit 8 isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000016.10) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011522813.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCCCGGGG TGAAACTGAC CACCCAGGCC TACTGCAAGA TGGTGCTGCA CGGCGCCAAG 
TACCCGCACT GCGCCGTCAA CGGGCTCCTG GTGGCCGAGA AGCAGAAGCC GCGTAAGGAG 
CACCTCCCCC TGGGCGGCCC CGGCGCCCAC CACACCCTCT TCGTGGACTG CATCCCCCTC 
TTCCACGGCA CCCTGGCCCT CGCCCCCATG CTGGAGGTGG CTCTCACCCT GATTGATTCA 
TGGTGCAAAG ATCATAGCTA CGTGATTGCT GGTTATTATC AAGCTAATGA GCGAGTAAAG 
GATGCCAGCA ATGCACAAGT GAAGAAACCA GCCGGAGAAG GTGGCTTCTC AGAGGCCACA 
CAGCTTGGGA GCTCAGGAGC TAGGATCATG CCAACTTCTG ACTTAAAAAT ATTGCCTCAT 
TCACAGTGTC TTGCAGCATG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011521115.1
CDS	450..890
Translation	MPGVKLTTQAYCKMVLHGAKYPHCAVNGLLVAEKQKPRKEHLPLGGPGAHHTLFVDCIPLFHGTLALAPMLEVALTLIDSWCKDHSYVIAGYYQANERVKDASNAQVKKPAGEGGFSEATQLGSSGARIMPTSDLKILPHSQCLAA

Target ORF information:

RefSeq Version	XM_011522813.2
Organism	Homo sapiens(human)
Definition	Homo sapiens ER membrane protein complex subunit 8 (EMC8), transcript variant X3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011522813.2

ORF Insert Sequence:

ATGCCCGGGG TGAAACTGAC CACCCAGGCC TACTGCAAGA TGGTGCTGCA CGGCGCCAAG 
TACCCGCACT GCGCCGTCAA CGGGCTCCTG GTGGCCGAGA AGCAGAAGCC GCGTAAGGAG 
CACCTCCCCC TGGGCGGCCC CGGCGCCCAC CACACCCTCT TCGTGGACTG CATCCCCCTC 
TTCCACGGCA CCCTGGCCCT CGCCCCCATG CTGGAGGTGG CTCTCACCCT GATTGATTCA 
TGGTGCAAAG ATCATAGCTA CGTGATTGCT GGTTATTATC AAGCTAATGA GCGAGTAAAG 
GATGCCAGCA ATGCACAAGT GAAGAAACCA GCCGGAGAAG GTGGCTTCTC AGAGGCCACA 
CAGCTTGGGA GCTCAGGAGC TAGGATCATG CCAACTTCTG ACTTAAAAAT ATTGCCTCAT 
TCACAGTGTC TTGCAGCATG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

EMC8 ( XM_017022867.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016878356.1 Homo sapiens ER membrane protein complex subunit 8 (EMC8), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu85813
Clone ID Related Accession (Same CDS sequence)	XM_017022867.1
Accession Version	XM_017022867.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 477bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	ER membrane protein complex subunit 8 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000016.10) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGACATTTT TCTGCTGGAA TTTGGTTGGG CCCTTGGAGT TTTCTTACAG GAATTTGTCC 
CTCAGCAGGC AAAATATTGA TTCATGGTGC AAAGATCATA GCTACGTGAT TGCTGGTTAT 
TATCAAGCTA ATGAGCGAGT AAAGGATGCC AGTCCAAACC AGGTTGCAGA GAAGGTGGCC 
TCCAGAATCG CCGAGGGCTT CAGCGACACT GCGCTCATCA TGGTAGACAA CACCAAGTTT 
ACGATGGACT GCGTAGCGCC TACGATCCAC GTGTACGAGC ACCATGAGAA CAGATGGCGG 
TGCAGAGACC CACACCATGA CTACTGTGAA GACTGGCCAG AGGCACAGAG GATCTCAGCC 
TCGCTCCTGG ACAGCCGGTC CTACGAGACG CTCGTGGATT TCGATAACCA CCTGGATGAC 
ATTCGGAATG ACTGGACAAA CCCAGAGATC AATAAAGCTG TCCTACACTT GTGCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016878356.1
CDS	95..571
Translation	MTFFCWNLVGPLEFSYRNLSLSRQNIDSWCKDHSYVIAGYYQANERVKDASPNQVAEKVASRIAEGFSDTALIMVDNTKFTMDCVAPTIHVYEHHENRWRCRDPHHDYCEDWPEAQRISASLLDSRSYETLVDFDNHLDDIRNDWTNPEINKAVLHLC

Target ORF information:

RefSeq Version	XM_017022867.1
Organism	Homo sapiens(human)
Definition	Homo sapiens ER membrane protein complex subunit 8 (EMC8), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017022867.1

ORF Insert Sequence:

ATGACATTTT TCTGCTGGAA TTTGGTTGGG CCCTTGGAGT TTTCTTACAG GAATTTGTCC 
CTCAGCAGGC AAAATATTGA TTCATGGTGC AAAGATCATA GCTACGTGAT TGCTGGTTAT 
TATCAAGCTA ATGAGCGAGT AAAGGATGCC AGTCCAAACC AGGTTGCAGA GAAGGTGGCC 
TCCAGAATCG CCGAGGGCTT CAGCGACACT GCGCTCATCA TGGTAGACAA CACCAAGTTT 
ACGATGGACT GCGTAGCGCC TACGATCCAC GTGTACGAGC ACCATGAGAA CAGATGGCGG 
TGCAGAGACC CACACCATGA CTACTGTGAA GACTGGCCAG AGGCACAGAG GATCTCAGCC 
TCGCTCCTGG ACAGCCGGTC CTACGAGACG CTCGTGGATT TCGATAACCA CCTGGATGAC 
ATTCGGAATG ACTGGACAAA CCCAGAGATC AATAAAGCTG TCCTACACTT GTGCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Architecture of the human interactome defines protein communities and disease networks.
Nature545(7655)505-509(2017 05)
Huttlin EL,Bruckner RJ,Paulo JA,Cannon JR,Ting L,Baltier K,Colby G,Gebreab F,Gygi MP,Parzen H,Szpyt J,Tam S,Zarraga G,Pontano-Vaites L,Swarup S,White AE,Schweppe DK,Rad R,Erickson BK,Obar RA,Guruharsha KG,Li K,Artavanis-Tsakonas S,Gygi SP,Harper JW

A human interactome in three quantitative dimensions organized by stoichiometries and abundances.
Cell163(3)712-23(2015 Oct)
Hein MY,Hubner NC,Poser I,Cox J,Nagaraj N,Toyoda Y,Gak IA,Weisswange I,Mansfeld J,Buchholz F,Hyman AA,Mann M

Defining human ERAD networks through an integrative mapping strategy.
Nature cell biology14(1)93-105(2011 Nov)
Christianson JC,Olzmann JA,Shaler TA,Sowa ME,Bennett EJ,Richter CM,Tyler RE,Greenblatt EJ,Harper JW,Kopito RR

MicroRNA-related genetic variations as predictors for risk of second primary tumor and/or recurrence in patients with early-stage head and neck cancer.
Carcinogenesis31(12)2118-23(2010 Dec)
Zhang X,Yang H,Lee JJ,Kim E,Lippman SM,Khuri FR,Spitz MR,Lotan R,Hong WK,Wu X

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EMC8 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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見積依頼

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FAX

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