GFRA1 cDNA ORF clone, Gallus gallus(chicken)

Gene
Clones
gRNAs

Summary

Gene Symbol	GFRA1
Entrez Gene ID	395994
Full Name	GDNF family receptor alpha 1
Synonyms	GDNFRALPHA
General protein information	Preferred Names GDNF family receptor alpha 1 Names GDNF family receptor alpha-1 GDNF receptor alpha GDNF receptor alpha-1 GDNFR-alpha-1 GFR-alpha-1 TGF-beta-related neurotrophic factor receptor 1
Gene Type	protein-coding
Organism	Gallus gallus(chicken)

mRNA and Protein(s)

mRNA	Protein	Name
NM_205102.1	NP_990433.1	GDNF family receptor alpha-1 precursor

Pathways from BioSystems

Homologies

Homo sapiens (human)	GFRA1	NP_005255.1
Pan troglodytes (chimpanzee)	GFRA1	XP_001150668.1
Danio rerio (zebrafish)	gfra1a	NP_571805.1
Danio rerio (zebrafish)	gfra1b	NP_571806.1
Canis lupus familiaris (dog)	GFRA1	XP_005637819.1
Mus musculus (house mouse)	Gfra1	NP_034409.1
Rattus norvegicus (Norway rat)	Gfra1	NP_037091.1
Xenopus tropicalis (tropical clawed frog)	gfra1	NP_001096555.1
Bos taurus (cattle)	GFRA1	NP_001098881.1
Gallus gallus (chicken)	GFRA1	NP_990433.1

Gene Ontology
Bibliography

Related articles in PubMed

Neurogenin2 expression together with NeuroM regulates GDNF family neurotrophic factor receptor ?1 (GFR?1) expression in the embryonic spinal cord.
Shimada T, Yaginuma H, Sato N, Homma S
Developmental biology370(2)250-63(2012 Oct)

Specificity in the crosstalk of TGFbeta/GDNF family members is determined by distinct GFR alpha receptors.
Peterziel H, Paech T, Strelau J, Unsicker K, Krieglstein K
Journal of neurochemistry103(6)2491-504(2007 Dec)

Neurturin responsiveness requires a GPI-linked receptor and the Ret receptor tyrosine kinase.
Buj-Bello A, Adu J, Pi??n LG, Horton A, Thompson J, Rosenthal A, Chinchetru M, Buchman VL, Davies AM
Nature387(6634)721-4(1997 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Ngn2 together with NeuroM serves as readout to regulate GFRalpha1 expression, which occurs in multiple subtypes of spinal neurons.
Title: Neurogenin2 expression together with NeuroM regulates GDNF family neurotrophic factor receptor ?1 (GFR?1) expression in the embryonic spinal cord.

We propose a model taking into account data from GFRalpha1 crystallization and ontogenetic development of the CG that may explain the differences in TGFbeta-dependence of GDNF and NRTN.
Title: Specificity in the crosstalk of TGFbeta/GDNF family members is determined by distinct GFR alpha receptors.

The following GFRA1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the GFRA1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OGa26692	NM_205102.1 Latest version!	Gallus gallus GDNF family receptor alpha 1 (GFRA1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$258.30 $369.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

GFRA1 ( NM_205102.1 ) cDNA ORF clone, Gallus gallus(chicken) -> NP_990433.1 Gallus gallus GDNF family receptor alpha 1 (GFRA1), mRNA.

Price & Availability↑

CloneID	OGa26692
Clone ID Related Accession (Same CDS sequence)	NM_205102.1
Accession Version	NM_205102.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1410bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-25
Organism	Gallus gallus(chicken)
Product	GDNF family receptor alpha-1 precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from U90541.1. ##Evidence-Data-START## Transcript exon combination :: U90541.1 [ECO:0000332] ##Evidence-Data-END##

ATGTTCCTCG CGCTCCTCTA CTTGGCTCTG CCCTTAGCGG ACGTACTTCT GTCGGCAGAA 
GTCAGCGGGC TGCCCGGAGG GGACCGCCTC GACTGCGTGA AAGCCAGCGA TCAGTGTCTC 
AAGGAGCAGA GCTGTAGTAC TAAGTACAGG ACACTGAGGC AGTGTGTAGC CGGCAAAGAG 
AGCAACTTCA GCCGGGCGAC GGGCCTGGAG GCGAAGGATG AATGCAAAAG CGCCATGGAG 
GCTCTCAAGC AGAAATCTCT GTACAACTGC CGCTGCAAGA GGGGCATGAA GAAGGAGAAA 
AACTGCCTGC GCATTTACTG GAGCATGTAC CAGAGCTTAC AGGGAAATGA CTTGCTTGAG 
GATTCTCCCT ATGAACCAGT TAACAGCAGG CTATCAGACA TATTCAGGCT AGCACCGATT 
GTATCAGTGG AGCCAGTACT ATCAAAGGGG AACAACTGCT TGGATGCAGC AAAAGCTTGT 
AACCTAAATG ATACCTGCAA GAGGTTCAGA TCTGCTTACA TAACCCCCTG CACCAGCAGC 
ACGTCTAATG AAATCTGTAA CAAGCGGAAG TGTCATAAGG CCCTCCGGCT ATTTTTTGAC 
AAAGTTCCCC CAAAGCACAG CTACGGGATG CTCTTCTGCT CCTGTCGAGA CGTAGCCTGT 
ACAGAAAGGA GGCGGCAGAC TATTGTTCCT GTGTGTTCAT ATGAGGACAG GGAGAAACCA 
AACTGCCTGA ATTTACAAGA ATCCTGCAAG AAGAATTACA TCTGCAGATC TCGCCTTGCA 
GATTTTTTCA CAAACTGCCA GCCTGAGTCA CGCTCTGTTA GTAGCTGTCT GAAGGAGAAC 
TACGCTGACT GCCTCCTCGC TTACTCGGGG CTCATTGGCA CAGTGATGAC ACCGAACTAC 
ATAGACTCAA GTAGTCTCAG CGTTGCCCCA TGGTGTGACT GCAGCAACAG TGGTAATGAC 
ATAGATGAAT GCCGGAAATT TCTGAATTTC TTCCAGGACA ACACATGCCT TAAAAATGCA 
ATTCAGGCTT TCGGCAATGG TACTGATGTG AATGTGTGGC AGCCAATATT ACCGGTACAG 
ACCACTACAG CCACAACTAC AACAGCTTCC AGACTTAAAA ACACAGGTTC AGAGACCACC 
AACAATGAAA TACCCACCCA CAATGATTCA CCAGCATGTG CGAACCTGCA GGCACAGAAG 
AAGCGGAAAT CCAATGAATC TGTAGATACA GAACTCTGTC TTAATGAGAA TGCTATTGGG 
AAAGACAACA CACCAGGAGT CTCCACCAGC CACATATCCT CGGAGAATTC TTTTGCCCTT 
CCTACAAGCT TCTATCCAAG CACACCACTC ATTCTGATGA CAATTGCACT CTCACTCTTT 
TTGTTCCTAA GCTCATCAGT CGTCTTGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_990433.1
CDS	740..2149
Translation	MFLALLYLALPLADVLLSAEVSGLPGGDRLDCVKASDQCLKEQSCSTKYRTLRQCVAGKESNFSRATGLEAKDECKSAMEALKQKSLYNCRCKRGMKKEKNCLRIYWSMYQSLQGNDLLEDSPYEPVNSRLSDIFRLAPIVSVEPVLSKGNNCLDAAKACNLNDTCKRFRSAYITPCTSSTSNEICNKRKCHKALRLFFDKVPPKHSYGMLFCSCRDVACTERRRQTIVPVCSYEDREKPNCLNLQESCKKNYICRSRLADFFTNCQPESRSVSSCLKENYADCLLAYSGLIGTVMTPNYIDSSSLSVAPWCDCSNSGNDIDECRKFLNFFQDNTCLKNAIQAFGNGTDVNVWQPILPVQTTTATTTTASRLKNTGSETTNNEIPTHNDSPACANLQAQKKRKSNESVDTELCLNENAIGKDNTPGVSTSHISSENSFALPTSFYPSTPLILMTIALSLFLFLSSSVVL

Target ORF information:

RefSeq Version	NM_205102.1
Organism	Gallus gallus(chicken)
Definition	Gallus gallus GDNF family receptor alpha 1 (GFRA1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_205102.1

ORF Insert Sequence:

ATGTTCCTCG CGCTCCTCTA CTTGGCTCTG CCCTTAGCGG ACGTACTTCT GTCGGCAGAA 
GTCAGCGGGC TGCCCGGAGG GGACCGCCTC GACTGCGTGA AAGCCAGCGA TCAGTGTCTC 
AAGGAGCAGA GCTGTAGTAC TAAGTACAGG ACACTGAGGC AGTGTGTAGC CGGCAAAGAG 
AGCAACTTCA GCCGGGCGAC GGGCCTGGAG GCGAAGGATG AATGCAAAAG CGCCATGGAG 
GCTCTCAAGC AGAAATCTCT GTACAACTGC CGCTGCAAGA GGGGCATGAA GAAGGAGAAA 
AACTGCCTGC GCATTTACTG GAGCATGTAC CAGAGCTTAC AGGGAAATGA CTTGCTTGAG 
GATTCTCCCT ATGAACCAGT TAACAGCAGG CTATCAGACA TATTCAGGCT AGCACCGATT 
GTATCAGTGG AGCCAGTACT ATCAAAGGGG AACAACTGCT TGGATGCAGC AAAAGCTTGT 
AACCTAAATG ATACCTGCAA GAGGTTCAGA TCTGCTTACA TAACCCCCTG CACCAGCAGC 
ACGTCTAATG AAATCTGTAA CAAGCGGAAG TGTCATAAGG CCCTCCGGCT ATTTTTTGAC 
AAAGTTCCCC CAAAGCACAG CTACGGGATG CTCTTCTGCT CCTGTCGAGA CGTAGCCTGT 
ACAGAAAGGA GGCGGCAGAC TATTGTTCCT GTGTGTTCAT ATGAGGACAG GGAGAAACCA 
AACTGCCTGA ATTTACAAGA ATCCTGCAAG AAGAATTACA TCTGCAGATC TCGCCTTGCA 
GATTTTTTCA CAAACTGCCA GCCTGAGTCA CGCTCTGTTA GTAGCTGTCT GAAGGAGAAC 
TACGCTGACT GCCTCCTCGC TTACTCGGGG CTCATTGGCA CAGTGATGAC ACCGAACTAC 
ATAGACTCAA GTAGTCTCAG CGTTGCCCCA TGGTGTGACT GCAGCAACAG TGGTAATGAC 
ATAGATGAAT GCCGGAAATT TCTGAATTTC TTCCAGGACA ACACATGCCT TAAAAATGCA 
ATTCAGGCTT TCGGCAATGG TACTGATGTG AATGTGTGGC AGCCAATATT ACCGGTACAG 
ACCACTACAG CCACAACTAC AACAGCTTCC AGACTTAAAA ACACAGGTTC AGAGACCACC 
AACAATGAAA TACCCACCCA CAATGATTCA CCAGCATGTG CGAACCTGCA GGCACAGAAG 
AAGCGGAAAT CCAATGAATC TGTAGATACA GAACTCTGTC TTAATGAGAA TGCTATTGGG 
AAAGACAACA CACCAGGAGT CTCCACCAGC CACATATCCT CGGAGAATTC TTTTGCCCTT 
CCTACAAGCT TCTATCCAAG CACACCACTC ATTCTGATGA CAATTGCACT CTCACTCTTT 
TTGTTCCTAA GCTCATCAGT CGTCTTGTAG