| Gene Symbol | IL1B |
| Entrez Gene ID | 768274 |
| Full Name | interleukin 1 beta |
| Gene Type | protein-coding |
| Organism | Felis catus(domestic cat) |
ORF » Species Summary » Felis catus » IL1B cDNA ORF clone
| Gene Symbol | IL1B |
| Entrez Gene ID | 768274 |
| Full Name | interleukin 1 beta |
| Gene Type | protein-coding |
| Organism | Felis catus(domestic cat) |
| mRNA | Protein | Name |
|---|---|---|
| NM_001077414.1 | NP_001070882.1 | interleukin-1 beta |
JNK activation is essential for activation of MEK/ERK signaling in IL-1?-induced COX-2 expression in synovial fibroblasts.
Kitanaka T, Nakano R, Kitanaka N, Kimura T, Okabayashi K, Narita T, Sugiya H
Scientific reports739914(2017 Jan)
Role of IL-1 beta and 5-HT2 receptors in midbrain periaqueductal gray (PAG) in potentiating defensive rage behavior in cat.
Bhatt S, Bhatt R, Zalcman SS, Siegel A
Brain, behavior, and immunity22(2)224-33(2008 Feb)
IL-1beta signaling in cat lower esophageal sphincter circular muscle.
Cao W, Cheng L, Behar J, Biancani P, Harnett KM
American journal of physiology. Gastrointestinal and liver physiology291(4)G672-80(2006 Oct)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
IL-beta in the dorsal periaqueductal gray, similar to the medial hypothalamus, potentiates defensive rage behavior and is mediated through a 5-HT(2C) receptor mechanism
Title: Role of IL-1 beta and 5-HT2 receptors in midbrain periaqueductal gray (PAG) in potentiating defensive rage behavior in cat.
data suggested that IL-1beta reduces lower esophageal sphincter tone by producing H(2)O(2), which may affect Ca(2+)-release mechanisms and increase the synthesis of COX-2 and PGE(2).
Title: IL-1beta signaling in cat lower esophageal sphincter circular muscle.
The following IL1B gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the IL1B cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
| CloneID | OFb00073 | |
| Clone ID Related Accession (Same CDS sequence) | NM_001077414.1 | |
| Accession Version | NM_001077414.1 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 804bp) Protein sequence SNP |
|
| Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-12-25 | |
| Organism | Felis catus(domestic cat) | |
| Product | interleukin-1 beta | |
| Comment | Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from M92060.1. ##Evidence-Data-START## Transcript exon combination :: M92060.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN04099974, SAMN04498518 [ECO:0000348] ##Evidence-Data-END## | |
1 | ATGGCACCAG TACCTGAACT CACCAGTGAA ATGATGGCTT ACTACAGTGA TGAGAATGAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_001070882.1 |
| CDS | 45..848 |
| Translation |
Target ORF information:
Target ORF information:
|
NM_001077414.1 |
1 | ATGGCACCAG TACCTGAACT CACCAGTGAA ATGATGGCTT ACTACAGTGA TGAGAATGAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
JNK activation is essential for activation of MEK/ERK signaling in IL-1?-induced COX-2 expression in synovial fibroblasts. |
Role of IL-1 beta and 5-HT2 receptors in midbrain periaqueductal gray (PAG) in potentiating defensive rage behavior in cat. |
IL-1beta signaling in cat lower esophageal sphincter circular muscle. |