CXCR4 cDNA ORF clone, Felis catus(domestic cat)

Gene
Clones
gRNAs

Summary

Gene Symbol	CXCR4
Entrez Gene ID	493676
Full Name	C-X-C motif chemokine receptor 4
Gene Type	protein-coding
Organism	Felis catus(domestic cat)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001009826.1	NP_001009826.1	C-X-C chemokine receptor type 4

Pathways from BioSystems
Gene Ontology
Bibliography

Related articles in PubMed

CD134 and CXCR4 expression corresponds to feline immunodeficiency virus infection of lymphocytes, macrophages and dendritic cells.
Reggeti F, Ackerley C, Bienzle D
The Journal of general virology89(Pt 1)277-87(2008 Jan)

Sequential CD134-CXCR4 interactions in feline immunodeficiency virus (FIV): soluble CD134 activates FIV Env for CXCR4-dependent entry and reveals a cryptic neutralization epitope.
de Parseval A, Grant CK, Sastry KJ, Elder JH
Journal of virology80(6)3088-91(2006 Mar)

Preferential feline immunodeficiency virus (FIV) infection of CD4+ CD25+ T-regulatory cells correlates both with surface expression of CXCR4 and activation of FIV long terminal repeat binding cellular transcriptional factors.
Joshi A, Garg H, Tompkins MB, Tompkins WA
Journal of virology79(8)4965-76(2005 Apr)

Feline peripheral blood mononuclear cells express message for both CXC and CC type chemokine receptors.
Kovacs EM, Baxter GD, Robinson WF
Archives of virology144(2)273-85(1999)

Shared usage of the chemokine receptor CXCR4 by the feline and human immunodeficiency viruses.
Willett BJ, Picard L, Hosie MJ, Turner JD, Adema K, Clapham PR
Journal of virology71(9)6407-15(1997 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Expression of CD134 and CXCR4 on feline T and B and dendritic cells (and macrophages was examined and the kinetics of feline immunodeficiency virus replication were assessed.
Title: CD134 and CXCR4 expression corresponds to feline immunodeficiency virus infection of lymphocytes, macrophages and dendritic cells.

These findings provide direct evidence for a sequential interaction of FIV Env with CD134 and CXCR4 .
Title: Sequential CD134-CXCR4 interactions in feline immunodeficiency virus (FIV): soluble CD134 activates FIV Env for CXCR4-dependent entry and reveals a cryptic neutralization epitope.

CD4+ CD25- cells were less susceptible to FIV binding and entry which correlated with increased surface expression of FIV coreceptor CXCR4.
Title: Preferential feline immunodeficiency virus (FIV) infection of CD4+ CD25+ T-regulatory cells correlates both with surface expression of CXCR4 and activation of FIV long terminal repeat binding cellular transcriptional factors.

The following CXCR4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CXCR4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OFb24835	NM_001009826.1 Latest version!	Felis catus C-X-C motif chemokine receptor 4 (CXCR4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$258.30 $369.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CXCR4 ( NM_001009826.1 ) cDNA ORF clone, Felis catus(domestic cat) -> NP_001009826.1 Felis catus C-X-C motif chemokine receptor 4 (CXCR4), mRNA.

Price & Availability↑

CloneID	OFb24835
Clone ID Related Accession (Same CDS sequence)	NM_001009826.1
Accession Version	NM_001009826.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1062bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-25
Organism	Felis catus(domestic cat)
Product	C-X-C chemokine receptor type 4
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AJ009816.1. ##Evidence-Data-START## Transcript exon combination :: AJ009816.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN04498517, SAMN04498518 [ECO:0000348] ##Evidence-Data-END##

ATGGACGGGT TTCGTATATA CCCTTCAGAT AACTACACCG AAGATGACTT GGGCTCAGGC 
GACTATGACT CCATGAAGGA ACCCTGCTTC CGGGAGGAAA ATGCCCATTT CAACCGTATC 
TTTCTGCCCA CTGTCTACTC CATCATCTTC TTGACTGGCA TAGTGGGCAA TGGATTGGTC 
ATCCTGGTCA TGGGTTACCA GAAGAAACTG AGAAGCATGA CAGACAAGTA CAGATTGCAC 
CTATCTGTGG CAGACCTCCT CTTTGTCCTC ACACTTCCCT TCTGGGCAGT TGATGCTGTG 
GCAAACTGGT ATTTTGGAAA GTTTCTGTGC AAGGCAGTCC ATGTCATCTA CACAGTCAAC 
CTCTACAGCA GTGTCCTCAT CCTGGCCTTC ATCAGTCTGG ACCGGTACTT GGCTATTGTC 
CATGCCACCA ACAGTCAGAG GCCAAGGAAG CTGTTGGCTG AAAAGGTGGT CTATGTTGGT 
GTCTGGATAC CTGCCCTCCT GTTGACTATT CCTGATTTCA TCTTTGCTAA TGTCAGAGAG 
GCAGATGGGA GGTATATCTG TGACCGCTTC TATCCCAGTG ACTCGTGGTT GGTGGTATTC 
CAGTTTCAGC ACATCATGGT TGGCCTTATC CTGCCAGGTA TTGTCATCCT GTCCTGCTAT 
TGCATTATCA TCTCCAAGCT CTCCCACTCC AAGGGCTACC AGAAGCGCAA GGCCCTCAAG 
ACCACAGTTA TCCTCATTCT GGCTTTCTTT GCCTGCTGGC TCCCCTACTA CATAGGGATC 
AGCATCGATT CCTTCATCCT CCTGGAAATC ATCAAGCAAG GATGTGAGTT TGAGAGCACT 
GTGCACAAGT GGATTTCCAT CACCGAGGCC CTAGCCTTTT TCCACTGTTG CCTGAACCCC 
ATCCTCTATG CCTTCCTTGG AGCCAAATTT AAAACCTCTG CCCAGCATGC ACTCACCTCT 
GTGAGCAGAG GGTCCAGCCT CAAGATCCTT TCCAAAGGGA AGCGGGGAGG ACATTCTTCT 
GTTTCAACTG AGTCCGAGTC TTCCAGTTTT CACTCCAGCT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001009826.1
CDS	70..1131
Translation	MDGFRIYPSDNYTEDDLGSGDYDSMKEPCFREENAHFNRIFLPTVYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVLTLPFWAVDAVANWYFGKFLCKAVHVIYTVNLYSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIPDFIFANVREADGRYICDRFYPSDSWLVVFQFQHIMVGLILPGIVILSCYCIIISKLSHSKGYQKRKALKTTVILILAFFACWLPYYIGISIDSFILLEIIKQGCEFESTVHKWISITEALAFFHCCLNPILYAFLGAKFKTSAQHALTSVSRGSSLKILSKGKRGGHSSVSTESESSSFHSS

Target ORF information:

RefSeq Version	NM_001009826.1
Organism	Felis catus(domestic cat)
Definition	Felis catus C-X-C motif chemokine receptor 4 (CXCR4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001009826.1

ORF Insert Sequence:

ATGGACGGGT TTCGTATATA CCCTTCAGAT AACTACACCG AAGATGACTT GGGCTCAGGC 
GACTATGACT CCATGAAGGA ACCCTGCTTC CGGGAGGAAA ATGCCCATTT CAACCGTATC 
TTTCTGCCCA CTGTCTACTC CATCATCTTC TTGACTGGCA TAGTGGGCAA TGGATTGGTC 
ATCCTGGTCA TGGGTTACCA GAAGAAACTG AGAAGCATGA CAGACAAGTA CAGATTGCAC 
CTATCTGTGG CAGACCTCCT CTTTGTCCTC ACACTTCCCT TCTGGGCAGT TGATGCTGTG 
GCAAACTGGT ATTTTGGAAA GTTTCTGTGC AAGGCAGTCC ATGTCATCTA CACAGTCAAC 
CTCTACAGCA GTGTCCTCAT CCTGGCCTTC ATCAGTCTGG ACCGGTACTT GGCTATTGTC 
CATGCCACCA ACAGTCAGAG GCCAAGGAAG CTGTTGGCTG AAAAGGTGGT CTATGTTGGT 
GTCTGGATAC CTGCCCTCCT GTTGACTATT CCTGATTTCA TCTTTGCTAA TGTCAGAGAG 
GCAGATGGGA GGTATATCTG TGACCGCTTC TATCCCAGTG ACTCGTGGTT GGTGGTATTC 
CAGTTTCAGC ACATCATGGT TGGCCTTATC CTGCCAGGTA TTGTCATCCT GTCCTGCTAT 
TGCATTATCA TCTCCAAGCT CTCCCACTCC AAGGGCTACC AGAAGCGCAA GGCCCTCAAG 
ACCACAGTTA TCCTCATTCT GGCTTTCTTT GCCTGCTGGC TCCCCTACTA CATAGGGATC 
AGCATCGATT CCTTCATCCT CCTGGAAATC ATCAAGCAAG GATGTGAGTT TGAGAGCACT 
GTGCACAAGT GGATTTCCAT CACCGAGGCC CTAGCCTTTT TCCACTGTTG CCTGAACCCC 
ATCCTCTATG CCTTCCTTGG AGCCAAATTT AAAACCTCTG CCCAGCATGC ACTCACCTCT 
GTGAGCAGAG GGTCCAGCCT CAAGATCCTT TCCAAAGGGA AGCGGGGAGG ACATTCTTCT 
GTTTCAACTG AGTCCGAGTC TTCCAGTTTT CACTCCAGCT AA