| Gene Symbol | IL4 |
| Entrez Gene ID | 100034225 |
| Full Name | interleukin 4 |
| Synonyms | BSF-1,IL-4 |
| Gene Type | protein-coding |
| Organism | Equus caballus(horse) |
ORF » Species Summary » Equus caballus » IL4 cDNA ORF clone
| Gene Symbol | IL4 |
| Entrez Gene ID | 100034225 |
| Full Name | interleukin 4 |
| Synonyms | BSF-1,IL-4 |
| Gene Type | protein-coding |
| Organism | Equus caballus(horse) |
| mRNA | Protein | Name |
|---|---|---|
| NM_001082519.1 | NP_001075988.1 | interleukin-4 precursor |
Annotation of the Protein Coding Regions of the Equine Genome.
Hestand MS, Kalbfleisch TS, Coleman SJ, Zeng Z, Liu J, Orlando L, MacLeod JN
PloS one10(6)e0124375(2015)
Monoclonal antibodies to equine CD23 identify the low-affinity receptor for IgE on subpopulations of IgM+ and IgG1+ B-cells in horses.
Wagner B, Hillegas JM, Babasyan S
Veterinary immunology and immunopathology146(2)125-34(2012 Apr)
Interferon-gamma, interleukin-4 and interleukin-10 production by T helper cells reveals intact Th1 and regulatory TR1 cell activation and a delay of the Th2 cell response in equine neonates and foals.
Wagner B, Burton A, Ainsworth D
Veterinary research41(4)47(2010 Jul-Aug)
Clinical alterations and mRNA levels of IL-4 and IL-5 in bronchoalveolar cells of horses with transient pulmonary eosinophilia.
Riihim?ki M, Lillieh??k I, Raine A, Berg M, Pringle J
Research in veterinary science85(1)52-5(2008 Aug)
Molecular cloning and characterization of markers and cytokines for equid myeloid cells.
Steinbach F, Stark R, Ibrahim S, Gawad EA, Ludwig H, Walter J, Commandeur U, Mauel S
Veterinary immunology and immunopathology108(1-2)227-36(2005 Oct)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
The data suggested in foals there is an impaired Th2 response, the immune response is Th1 biased, interferon-gamma production is qualitatively similar to adult horses, and regulatory IL-10 production by T cells is mature.
Title: Interferon-gamma, interleukin-4 and interleukin-10 production by T helper cells reveals intact Th1 and regulatory TR1 cell activation and a delay of the Th2 cell response in equine neonates and foals.
This study showed that pronounced lung eosinophilia in horses can be transient, abate without specific treatment, and in this instance, lack correlation to upregulation of expression of either IL-4 or IL-5.
Title: Clinical alterations and mRNA levels of IL-4 and IL-5 in bronchoalveolar cells of horses with transient pulmonary eosinophilia.
The following IL4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the IL4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
| CloneID | OHb27979 | |
| Clone ID Related Accession (Same CDS sequence) | NM_001082519.1 | |
| Accession Version | NM_001082519.1 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 414bp) Protein sequence SNP |
|
| Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-09-21 | |
| Organism | Equus caballus(horse) | |
| Product | interleukin-4 precursor | |
| Comment | Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF305617.1. ##Evidence-Data-START## Transcript exon combination :: AF305617.1, EU000425.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2743238, SAMN00991830 [ECO:0000348] ##Evidence-Data-END## | |
1 | ATGGGTCTCA CCTACCAACT GATTCCAGCT CTGGTCTGCT TACTAGCATG TACCAGCAAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_001075988.1 |
| CDS | 1..414 |
| Translation |
Target ORF information:
Target ORF information:
|
NM_001082519.1 |
1 | ATGGGTCTCA CCTACCAACT GATTCCAGCT CTGGTCTGCT TACTAGCATG TACCAGCAAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Annotation of the Protein Coding Regions of the Equine Genome. |
Monoclonal antibodies to equine CD23 identify the low-affinity receptor for IgE on subpopulations of IgM+ and IgG1+ B-cells in horses. |
Interferon-gamma, interleukin-4 and interleukin-10 production by T helper cells reveals intact Th1 and regulatory TR1 cell activation and a delay of the Th2 cell response in equine neonates and foals. |
Clinical alterations and mRNA levels of IL-4 and IL-5 in bronchoalveolar cells of horses with transient pulmonary eosinophilia. |
Molecular cloning and characterization of markers and cytokines for equid myeloid cells. |