| Gene Symbol | IL6 |
| Entrez Gene ID | 100034196 |
| Full Name | interleukin 6 |
| Synonyms | IL-6 |
| Gene Type | protein-coding |
| Organism | Equus caballus(horse) |
ORF » Species Summary » Equus caballus » IL6 cDNA ORF clone
| Gene Symbol | IL6 |
| Entrez Gene ID | 100034196 |
| Full Name | interleukin 6 |
| Synonyms | IL-6 |
| Gene Type | protein-coding |
| Organism | Equus caballus(horse) |
| mRNA | Protein | Name |
|---|---|---|
| NM_001082496.2 | NP_001075965.2 | interleukin-6 precursor |
Annotation of the Protein Coding Regions of the Equine Genome.
Hestand MS, Kalbfleisch TS, Coleman SJ, Zeng Z, Liu J, Orlando L, MacLeod JN
PloS one10(6)e0124375(2015)
The production and distribution of IL-6 and TNF-a in subcutaneous adipose tissue and their correlation with serum concentrations in Welsh ponies with equine metabolic syndrome.
Basinska K, Marycz K, ?ieszek A, Nicpo? J
Journal of veterinary science16(1)113-20(2015)
Effects of interleukin-6 and interleukin-1? on expression of growth differentiation factor-5 and Wnt signaling pathway genes in equine chondrocytes.
Svala E, Thorfve AI, Ley C, Henriksson HK, Synnergren JM, Lindahl AH, Ekman S, Ski?ldebrand ES
American journal of veterinary research75(2)132-40(2014 Feb)
Enhanced IL-6 transcriptional response to adenosine receptor ligands in horses with lower airway inflammation.
Zhang L, Franchini M, Wehrli Eser M, Dip R
Equine veterinary journal44(1)81-7(2012 Jan)
A genetic variant near the equine interleukin 6 gene associated with copper:zinc ratio.
Beghelli D, Giacconi R, Mocchegiani E, Cipriano C, Malavolta M, Renieri C
Veterinary journal (London, England : 1997)190(2)e143-5(2011 Nov)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
These data suggest that IL-6 may play a key role in equine metabolic syndrome (EMS), and that pro-inflammatory cytokines levels in serum may serve as an additional tool for diagnosing EMS.
Title: The production and distribution of IL-6 and TNF-a in subcutaneous adipose tissue and their correlation with serum concentrations in Welsh ponies with equine metabolic syndrome.
IL-6 stimulation decreased chondrocyte expression of the canonical Wnt signaling pathway transactivator beta-catenin, induced expression of inhibitors of the Wnt pathway, and increased expression of GDF-5.
Title: Effects of interleukin-6 and interleukin-1? on expression of growth differentiation factor-5 and Wnt signaling pathway genes in equine chondrocytes.
study shows that IL-6 is rapidly induced in BAL-cells of airway-compromised horses in response to adenosine exposure, probably through A2BAR activation and that this effect can be modulated by A2AAR
Title: Enhanced IL-6 transcriptional response to adenosine receptor ligands in horses with lower airway inflammation.
Our data show the presence of a polymorphism downstream of the equine IL-6 gene that is associated with the basal Cu:Zn ratio in horses independent of breed.
Title: A genetic variant near the equine interleukin 6 gene associated with copper:zinc ratio.
Expression levels of IL-6 are significantly increased in peripheral blood mononuclear cells from trained horses compared to sedentary animals.
Title: Athletic humans and horses: comparative analysis of interleukin-6 (IL-6) and IL-6 receptor (IL-6R) expression in peripheral blood mononuclear cells in trained and untrained subjects at rest.
The following IL6 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the IL6 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
| CloneID | OHb28119 | |
| Clone ID Related Accession (Same CDS sequence) | NM_001082496.2 | |
| Accession Version | NM_001082496.2 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 627bp) Protein sequence SNP |
|
| Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-12-28 | |
| Organism | Equus caballus(horse) | |
| Product | interleukin-6 precursor | |
| Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AF005227.1 and U64794.1. On May 14, 2015 this sequence version replaced NM_001082496.1. ##Evidence-Data-START## Transcript exon combination :: U64794.1, EU438770.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2743238, SAMN00991820 [ECO:0000348] ##Evidence-Data-END## | |
1 | ATGAACTCCC TCTTCACAAG CACCGTCACT CCAGTTGCCT TCTCCCTGGG GCTGCTCCTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_001075965.2 |
| CDS | 1..627 |
| Translation |
Target ORF information:
Target ORF information:
|
NM_001082496.2 |
1 | ATGAACTCCC TCTTCACAAG CACCGTCACT CCAGTTGCCT TCTCCCTGGG GCTGCTCCTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Annotation of the Protein Coding Regions of the Equine Genome. |
The production and distribution of IL-6 and TNF-a in subcutaneous adipose tissue and their correlation with serum concentrations in Welsh ponies with equine metabolic syndrome. |
Effects of interleukin-6 and interleukin-1? on expression of growth differentiation factor-5 and Wnt signaling pathway genes in equine chondrocytes. |
Enhanced IL-6 transcriptional response to adenosine receptor ligands in horses with lower airway inflammation. |
A genetic variant near the equine interleukin 6 gene associated with copper:zinc ratio. |