dtx4a cDNA ORF clone, Danio rerio(zebrafish)

Gene
Clones
gRNAs

Summary

Gene Symbol	dtx4a
Entrez Gene ID	570481
Full Name	si:ch211-119e14.2
Synonyms	dtx1
General protein information	Preferred Names si:ch211-119e14.2 Names si:ch211-119e14.2 deltex1
Gene Type	protein-coding
Organism	Danio rerio(zebrafish)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001127308.1	NP_001120780.1	deltex 4, E3 ubiquitin ligase a

Pathways from BioSystems

Homologies

Homo sapiens (human)	DTX4	NP_055992.1
Rattus norvegicus (Norway rat)	Dtx4	NP_001041320.1
Bos taurus (cattle)	DTX4	XP_002693867.2
Pan troglodytes (chimpanzee)	DTX4	XP_508449.3
	DTX4	XP_001088765.1
Canis lupus familiaris (dog)	DTX4	XP_005631774.1
Mus musculus (house mouse)	Dtx4	NP_766030.3
Danio rerio (zebrafish)	dtx1	NP_001120780.1
Gallus gallus (chicken)	DTX4	XP_423367.4
Danio rerio (zebrafish)	zgc:163052	XP_002660570.1

Gene Ontology
Bibliography

Related articles in PubMed

Transcriptional and histological alterations in gonad of adult zebrafish after exposure to the synthetic progestin norgestrel.
Shi WJ, Zhao JL, Jiang YX, Huang GY, Liu YS, Zhang JN, Ying GG
Environmental toxicology and chemistry36(12)3267-3276(2017 Dec)

Evolution of complexity in the zebrafish synapse proteome.
Bay?s ?, Collins MO, Reig-Viader R, Gou G, Goulding D, Izquierdo A, Choudhary JS, Emes RD, Grant SG
Nature communications814613(2017 Mar)

Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database.
Pasquier J, Cabau C, Nguyen T, Jouanno E, Severac D, Braasch I, Journot L, Pontarotti P, Klopp C, Postlethwait JH, Guiguen Y, Bobe J
BMC genomics17368(2016 05)

Deltex1 is inhibited by the Notch-Hairy/E(Spl) signaling pathway and induces neuronal and glial differentiation.
Cheng YC, Huang YC, Yeh TH, Shih HY, Lin CY, Lin SJ, Chiu CC, Huang CW, Jiang YJ
Neural development1028(2015 Dec)

Notch signaling expands a pre-malignant pool of T-cell acute lymphoblastic leukemia clones without affecting leukemia-propagating cell frequency.
Blackburn JS, Liu S, Raiser DM, Martinez SA, Feng H, Meeker ND, Gentry J, Neuberg D, Look AT, Ramaswamy S, Bernards A, Trede NS, Langenau DM
Leukemia26(9)2069-78(2012 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Our results demonstrated that Dtx1 is regulated by Notch-Hairy/E(Spl) signaling and is a major factor specifically regulating neural differentiation.
Title: Deltex1 is inhibited by the Notch-Hairy/E(Spl) signaling pathway and induces neuronal and glial differentiation.

The following dtx4a gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the dtx4a cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ODa35476	NM_001127308.1 Latest version!	Danio rerio deltex 4, E3 ubiquitin ligase a (dtx4a), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$426.30 $609.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

dtx4a ( NM_001127308.1 ) cDNA ORF clone, Danio rerio(zebrafish) -> NP_001120780.1 Danio rerio deltex 4, E3 ubiquitin ligase a (dtx4a), mRNA.

Price & Availability↑

CloneID	ODa35476
Clone ID Related Accession (Same CDS sequence)	NM_001127308.1
Accession Version	NM_001127308.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2115bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-07
Organism	Danio rerio(zebrafish)
Product	deltex 4, E3 ubiquitin ligase a
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from DQ497599.1. On Jul 31, 2008 this sequence version replaced XM_693966.3. ##Evidence-Data-START## Transcript exon combination :: DQ497599.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4476756, SAMEA4476788 [ECO:0000348] ##Evidence-Data-END##

ATGTTGTTAG CCTCGGCCGT GGTCGTCTGG GAATGGCTGA ACGAGCACGG GCGCTGGCGA 
CCCTACAGCC CAGCGGTGTC CCATCACATC GAGGCGGTGA TCCGCAGCGA CCCTCGCGGC 
GCCGGGAGCG TGGTGCTGGG CCAGGTCGAC TCACGTCTAT CGCCGTACAT CATTGACCTG 
CAGTCTATGC ACCAGTTTCG GCAAGACACC GGTACACTAA GACCTGTGCG GCGAAGTTTC 
TATGATCCAC GGTCGGCTCC AGGCCAGGGT TGGGTGTGGG AATGGGAGAA CGACTCTGGT 
TCATGGACGC CGTACGACAC CGAGGTGAGC ATCGCCATCC AGGCGGCTCG GGACCGGCAG 
CAGCCCTGGC TGGACTTAAC GCCGCTGGGC TTCTGCTACC TCATAGACCT GCAGAGTATG 
ACACAGATTA ATGGACAGAC GCAGCGGCGC CGGCGCATCC AGAGGCGCTC AGACTTGGCA 
TACCCCCTAG TCTCTGGCCC ACTTCCTAAA CCACATGCGT GGTCATCCGC TGGAAGTGGT 
GGACTGTTGG GTGTGGGCGT TTCAGGGGTC AGTGGAGGGA ATGGCAGTGC CTATCCCAGT 
GGAGCGCTCC CAGCTTCTGC TATTACTTCA CTGGGTCAGC CGTGTTCCTG CCAGCAGTGT 
ATGTTAGTCT TAGGTGTCAA GACCCCAAGC ATGGCACAAA CTCTTGGGCG GAAACCCCCG 
CCAATACCCA AGCCACCAAG TCCCAAAGCT CCATCAAGAG GACACTCATA CTCGCTAACC 
CTGCCTCACC CTCCTTCCCT TTCCCGAGTC CTCTCGCCAC ATAGGAACTC CACTTCGGGT 
GCTAGCGGAG GCTTCGGACA CTCCCTCTCC CTGTTGGGCT CAGCCACTGC CGCTTTGTCC 
ATATCCTCCA ACCGTCCTCC CCCACCTACT GTACCGCCAC CTCCGCCCCC ATCAACCACA 
CCTCATACCA CCTCCATGGC CAACCCTACA GCGCCTACAC CCTCTAGCAC CCTTATATCT 
ACAGCGACCA CCTGTGCTCC CACGCCCTCT GCTCGTGTTC TTGGTCCTGT GTCGACAGCG 
TCAGCAGCTT GTGCCGCCCC GGTGCCGCCT TGCAGTAGTC TGGCTGGTCT TAGCCGTCCC 
GCCCTACAGA GAATCGCAAT GGCACAGTCA CGGGCACTCA TTGCATCAGG AGTCCCCACC 
GTCCCTGTGA AGAACTTAAA TGGATCCAGT CCTGTTCATC CCGCTCTGGC AGGAATCACT 
GGTATTCTGA TGAGCGCTGC TGGACTGCCG GTCTGCTTGA CCCGCCCACC TAAACTGGTG 
CTCCACCCTC CACCTGTCAG CAAGAGTGAC ATCAAACCTG TGCCAGGCCT CGGCCACTGC 
TGCCGGAAAA CCACTAAAAA ACAAGCCCGC AAAGGTAGGA CTTCAGAAGA AGTTGTTAGG 
CGGTATCTTC AGAAAGTCCG CAACCCACCA GAGGAGGACT GCACAATTTG CATGGAGTCT 
CTGTGTGGGC CGTCCGGCTA TAAAGGACCA GGCGTGGGTG GTATTTCTCG GGCCGAGTCA 
GTGGGCCGTC TGTCTCAGTG CGGGCATCAG TACCACCTGC AGTGCCTGGT GGCCATGTAC 
AACAACGGCA ACAAGGACGG CAGCCTTCAG TGTCCCACCT GCAAGACCAT ATACGGTGTC 
AAAACCGGCA ACCAGCCACC AGGCAAGATG GAGTACCACG TCATTCCACA CTCGCTACCC 
GGACACCCCG ACTGCAAAAC CATTCGGATT ATCTACAACA TCCCCCCTGG CATTCAGGGT 
CCGGAGCATC CAAACCCCGG GAAACCCTTC ACCGCTCGTG GATTTCCCAG ACACTGCTAC 
CTCCCTGACA GTGAGAAAGG CCGTCTGGTG TTGAAGCTGT TGCTGGTTGC CTGGGACCGC 
CGGCTGATCT TCTCGGTGGG CACATCCAGC ACCACAGGCG AGACGGACAC AGTCATTTGG 
AACGAGGTGC ATCACAAAAC CGAATTCGGC TCCAATCTGA CGGGCCACGG TTACCCTGAC 
TCGGGCCACC TGGATAACGT CCTGAAGGAG CTGCGGGCGC AGGGCATCAC TGAGGAGGAG 
TGTCTGAGGG ACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001120780.1
CDS	335..2449
Translation	MLLASAVVVWEWLNEHGRWRPYSPAVSHHIEAVIRSDPRGAGSVVLGQVDSRLSPYIIDLQSMHQFRQDTGTLRPVRRSFYDPRSAPGQGWVWEWENDSGSWTPYDTEVSIAIQAARDRQQPWLDLTPLGFCYLIDLQSMTQINGQTQRRRRIQRRSDLAYPLVSGPLPKPHAWSSAGSGGLLGVGVSGVSGGNGSAYPSGALPASAITSLGQPCSCQQCMLVLGVKTPSMAQTLGRKPPPIPKPPSPKAPSRGHSYSLTLPHPPSLSRVLSPHRNSTSGASGGFGHSLSLLGSATAALSISSNRPPPPTVPPPPPPSTTPHTTSMANPTAPTPSSTLISTATTCAPTPSARVLGPVSTASAACAAPVPPCSSLAGLSRPALQRIAMAQSRALIASGVPTVPVKNLNGSSPVHPALAGITGILMSAAGLPVCLTRPPKLVLHPPPVSKSDIKPVPGLGHCCRKTTKKQARKGRTSEEVVRRYLQKVRNPPEEDCTICMESLCGPSGYKGPGVGGISRAESVGRLSQCGHQYHLQCLVAMYNNGNKDGSLQCPTCKTIYGVKTGNQPPGKMEYHVIPHSLPGHPDCKTIRIIYNIPPGIQGPEHPNPGKPFTARGFPRHCYLPDSEKGRLVLKLLLVAWDRRLIFSVGTSSTTGETDTVIWNEVHHKTEFGSNLTGHGYPDSGHLDNVLKELRAQGITEEECLRD

Target ORF information:

RefSeq Version	NM_001127308.1
Organism	Danio rerio(zebrafish)
Definition	Danio rerio deltex 4, E3 ubiquitin ligase a (dtx4a), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001127308.1

ORF Insert Sequence:

ATGTTGTTAG CCTCGGCCGT GGTCGTCTGG GAATGGCTGA ACGAGCACGG GCGCTGGCGA 
CCCTACAGCC CAGCGGTGTC CCATCACATC GAGGCGGTGA TCCGCAGCGA CCCTCGCGGC 
GCCGGGAGCG TGGTGCTGGG CCAGGTCGAC TCACGTCTAT CGCCGTACAT CATTGACCTG 
CAGTCTATGC ACCAGTTTCG GCAAGACACC GGTACACTAA GACCTGTGCG GCGAAGTTTC 
TATGATCCAC GGTCGGCTCC AGGCCAGGGT TGGGTGTGGG AATGGGAGAA CGACTCTGGT 
TCATGGACGC CGTACGACAC CGAGGTGAGC ATCGCCATCC AGGCGGCTCG GGACCGGCAG 
CAGCCCTGGC TGGACTTAAC GCCGCTGGGC TTCTGCTACC TCATAGACCT GCAGAGTATG 
ACACAGATTA ATGGACAGAC GCAGCGGCGC CGGCGCATCC AGAGGCGCTC AGACTTGGCA 
TACCCCCTAG TCTCTGGCCC ACTTCCTAAA CCACATGCGT GGTCATCCGC TGGAAGTGGT 
GGACTGTTGG GTGTGGGCGT TTCAGGGGTC AGTGGAGGGA ATGGCAGTGC CTATCCCAGT 
GGAGCGCTCC CAGCTTCTGC TATTACTTCA CTGGGTCAGC CGTGTTCCTG CCAGCAGTGT 
ATGTTAGTCT TAGGTGTCAA GACCCCAAGC ATGGCACAAA CTCTTGGGCG GAAACCCCCG 
CCAATACCCA AGCCACCAAG TCCCAAAGCT CCATCAAGAG GACACTCATA CTCGCTAACC 
CTGCCTCACC CTCCTTCCCT TTCCCGAGTC CTCTCGCCAC ATAGGAACTC CACTTCGGGT 
GCTAGCGGAG GCTTCGGACA CTCCCTCTCC CTGTTGGGCT CAGCCACTGC CGCTTTGTCC 
ATATCCTCCA ACCGTCCTCC CCCACCTACT GTACCGCCAC CTCCGCCCCC ATCAACCACA 
CCTCATACCA CCTCCATGGC CAACCCTACA GCGCCTACAC CCTCTAGCAC CCTTATATCT 
ACAGCGACCA CCTGTGCTCC CACGCCCTCT GCTCGTGTTC TTGGTCCTGT GTCGACAGCG 
TCAGCAGCTT GTGCCGCCCC GGTGCCGCCT TGCAGTAGTC TGGCTGGTCT TAGCCGTCCC 
GCCCTACAGA GAATCGCAAT GGCACAGTCA CGGGCACTCA TTGCATCAGG AGTCCCCACC 
GTCCCTGTGA AGAACTTAAA TGGATCCAGT CCTGTTCATC CCGCTCTGGC AGGAATCACT 
GGTATTCTGA TGAGCGCTGC TGGACTGCCG GTCTGCTTGA CCCGCCCACC TAAACTGGTG 
CTCCACCCTC CACCTGTCAG CAAGAGTGAC ATCAAACCTG TGCCAGGCCT CGGCCACTGC 
TGCCGGAAAA CCACTAAAAA ACAAGCCCGC AAAGGTAGGA CTTCAGAAGA AGTTGTTAGG 
CGGTATCTTC AGAAAGTCCG CAACCCACCA GAGGAGGACT GCACAATTTG CATGGAGTCT 
CTGTGTGGGC CGTCCGGCTA TAAAGGACCA GGCGTGGGTG GTATTTCTCG GGCCGAGTCA 
GTGGGCCGTC TGTCTCAGTG CGGGCATCAG TACCACCTGC AGTGCCTGGT GGCCATGTAC 
AACAACGGCA ACAAGGACGG CAGCCTTCAG TGTCCCACCT GCAAGACCAT ATACGGTGTC 
AAAACCGGCA ACCAGCCACC AGGCAAGATG GAGTACCACG TCATTCCACA CTCGCTACCC 
GGACACCCCG ACTGCAAAAC CATTCGGATT ATCTACAACA TCCCCCCTGG CATTCAGGGT 
CCGGAGCATC CAAACCCCGG GAAACCCTTC ACCGCTCGTG GATTTCCCAG ACACTGCTAC 
CTCCCTGACA GTGAGAAAGG CCGTCTGGTG TTGAAGCTGT TGCTGGTTGC CTGGGACCGC 
CGGCTGATCT TCTCGGTGGG CACATCCAGC ACCACAGGCG AGACGGACAC AGTCATTTGG 
AACGAGGTGC ATCACAAAAC CGAATTCGGC TCCAATCTGA CGGGCCACGG TTACCCTGAC 
TCGGGCCACC TGGATAACGT CCTGAAGGAG CTGCGGGCGC AGGGCATCAC TGAGGAGGAG 
TGTCTGAGGG ACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Transcriptional and histological alterations in gonad of adult zebrafish after exposure to the synthetic progestin norgestrel.
Environmental toxicology and chemistry36(12)3267-3276(2017 Dec)
Shi WJ,Zhao JL,Jiang YX,Huang GY,Liu YS,Zhang JN,Ying GG

Evolution of complexity in the zebrafish synapse proteome.
Nature communications814613(2017 Mar)
Bay?s ?,Collins MO,Reig-Viader R,Gou G,Goulding D,Izquierdo A,Choudhary JS,Emes RD,Grant SG

Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database.
BMC genomics17368(2016 05)
Pasquier J,Cabau C,Nguyen T,Jouanno E,Severac D,Braasch I,Journot L,Pontarotti P,Klopp C,Postlethwait JH,Guiguen Y,Bobe J

Deltex1 is inhibited by the Notch-Hairy/E(Spl) signaling pathway and induces neuronal and glial differentiation.
Neural development1028(2015 Dec)
Cheng YC,Huang YC,Yeh TH,Shih HY,Lin CY,Lin SJ,Chiu CC,Huang CW,Jiang YJ

Notch signaling expands a pre-malignant pool of T-cell acute lymphoblastic leukemia clones without affecting leukemia-propagating cell frequency.
Leukemia26(9)2069-78(2012 Sep)
Blackburn JS,Liu S,Raiser DM,Martinez SA,Feng H,Meeker ND,Gentry J,Neuberg D,Look AT,Ramaswamy S,Bernards A,Trede NS,Langenau DM