aurka cDNA ORF clone, Danio rerio(zebrafish)

Gene
Clones
gRNAs

Summary

Gene Symbol	aurka
Entrez Gene ID	445246
Full Name	aurora kinase A
Synonyms	wu:fb37c10,wu:fc02c02,zgc:100912
General protein information	Preferred Names aurora kinase A Names aurora kinase A fb37c10 fc02c02 serine/threonine-protein kinase 6
Gene Type	protein-coding
Organism	Danio rerio(zebrafish)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001003640.2	NP_001003640.1	aurora kinase A

Pathways from BioSystems

Homologies

Bos taurus (cattle)	AURKA	NP_001033117.1
Danio rerio (zebrafish)	aurka	NP_001003640.1
Gallus gallus (chicken)	AURKA	XP_425725.1
Magnaporthe oryzae (rice blast fungus)	MGG_12408	XP_003715581.1
Arabidopsis thaliana (thale cress)	AUR2	NP_180159.2
Canis lupus familiaris (dog)	AURKA	XP_005635253.1
Rattus norvegicus (Norway rat)	Aurka	NP_695208.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP001793	XP_321274.5
Oryza sativa (rice)	Os01g0191800	NP_001042274.1
Xenopus tropicalis (tropical clawed frog)	aurka	NP_001016570.1
Homo sapiens (human)	AURKA	NP_940838.1
Pan troglodytes (chimpanzee)	AURKA	NP_001233545.1
Mus musculus (house mouse)	Aurka	NP_035627.1
Caenorhabditis elegans (roundworm)	air-2	NP_491714.1
	AURKA	XP_002798130.1
Drosophila melanogaster (fruit fly)	aur	NP_476749.1
Arabidopsis thaliana (thale cress)	AUR1	NP_195009.1

Gene Ontology
Bibliography

Related articles in PubMed

Rosmarinic acid plays a protective role in the embryogenesis of zebrafish exposed to food colours through its influence on aurora kinase A level.
Swarnalatha Y, Jerrine Joseph IS, Jayakrishna T
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie891166-1171(2017 May)

RFX transcription factors are essential for hearing in mice.
Elkon R, Milon B, Morrison L, Shah M, Vijayakumar S, Racherla M, Leitch CC, Silipino L, Hadi S, Weiss-Gayet M, Barras E, Schmid CD, Ait-Lounis A, Barnes A, Song Y, Eisenman DJ, Eliyahu E, Frolenkov GI, Strome SE, Durand B, Zaghloul NA, Jones SM, Reith W, Hertzano R
Nature communications68549(2015 Oct)

Early depletion of primordial germ cells in zebrafish promotes testis formation.
Tzung KW, Goto R, Saju JM, Sreenivasan R, Saito T, Arai K, Yamaha E, Hossain MS, Calvert ME, Orb?n L
Stem cell reports4(1)61-73(2015 Jan)

Microtubule-associated protein 9 (Map9/Asap) is required for the early steps of zebrafish development.
Fontenille L, Rouquier S, Lutfalla G, Giorgi D
Cell cycle (Georgetown, Tex.)13(7)1101-14(2014)

Depletion of Aurora-A in zebrafish causes growth retardation due to mitotic delay and p53-dependent cell death.
Jeon HY, Lee H
The FEBS journal280(6)1518-30(2013 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Zebrafish Aurora-A is critically required for embryonic proliferation during development.
Title: Depletion of Aurora-A in zebrafish causes growth retardation due to mitotic delay and p53-dependent cell death.

The following aurka gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the aurka cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ODa34871	NM_001003640.2 Latest version!	Danio rerio aurora kinase A (aurka), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$258.30 $369.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

aurka ( NM_001003640.2 ) cDNA ORF clone, Danio rerio(zebrafish) -> NP_001003640.1 Danio rerio aurora kinase A (aurka), mRNA.

Price & Availability↑

CloneID	ODa34871
Clone ID Related Accession (Same CDS sequence)	NM_001003640.2
Accession Version	NM_001003640.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1218bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-11-23
Organism	Danio rerio(zebrafish)
Product	aurora kinase A
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC078304.1. On Aug 30, 2012 this sequence version replaced NM_001003640.1. ##Evidence-Data-START## Transcript exon combination :: BC078304.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2168446, SAMEA2168447 [ECO:0000348] ##Evidence-Data-END##

ATGGACTCTG GTGCAAGAAG CAAATCAAGC AGAGATCTGA AGATTCATCG ACCTGAAAAT 
GAGAAGGTTT CTGCCGCTGG ACCCAAAAGA GTTCCTGTAA CCCAGAGCGT GCAGAAGCCA 
GTGTCGAACC CACACACGCG TGTTCTCGGC GCTGCACAGG GACCACAGCG TGTCCAACGT 
CCTGTTGGGA AAACCTCTTG TCCTGGAGAC CAGAACACCC GTCCAGAACA GCACAAACCA 
GCAGCGCACA GCAAACCACA GCCAAAACCA CCGCTGTCAG CGGAGACCAA CAAAACTGCA 
GAACCCAGCA AACAGGATAA ACCTCACCAA ACTCCTTCCA GTACTACTTC TACCTCCTCC 
AACACCAGTG GATCATCGAA GAGTTCAAAA AAAGCCTGGA CTTTGGAGAA TTTCGACATT 
GGCCGCGCTC TGGGCAAGGG GAAGTTTGGC AGCGTGTATC TGGCCAGAGA ACAGCAGACC 
AAGTTTATTC TGGCGCTCAA AGTTCTGTTC AAGAAGCAGC TGGAGAAAGC AGGAGTGGAG 
CATCAGCTGC GCAGGGAGGT GGAGATACAG TCACATCTCA GACATCCCAA TATCCTGCGT 
TTGTATGGTT ATTTCCACGA CGCGGCCCGT GTTTACCTCA TCCTAGAGTT TGCTCCTAAA 
GGAGAGCTGT ATGGAGAACT GCAGCGCTGC GGGACGTTCG ATGACCAGAG AAGCGCCACG 
TATATAATGG AGTTGGCGGA TGCTCTGAGA TACTGCCACT CGAAGGCTGT GATCCACAGA 
GATATTAAAC CTGAAAACCT GCTGCTGGGA GCCAATGGAG AGCTGAAGAT TGCAGATTTT 
GGCTGGTCCG TCCACACGCC CTCCTCCAGG AGGTCGACGC TGTGCGGCAC ACTGGACTAT 
CTTCCTCCAG AGATGATTGA AGGTAAAACA CATGATGAGA AGGTGGATCT CTGGAGTCTT 
GGAGTGCTCT GCTATGAGTT TCTGGTTGGC AGGCCACCTT TTGAAACAAA GAGTCATGAA 
GAGACGTACC GCAAGATTTC TAGAGTTGAG TTTACTTATC CAGCTCATGT GAGCAACGGC 
AGCAGAGACC TGATCAATCG ACTACTCAAG CACAACCCAA TGCACAGACT CCCCATCCAG 
GGAGTAATGG AGCACCCGTG GGTTGTGGAA AACTCCACCA AGAAACCAAC CACTTACACC 
GCCACCGCCA ACAACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001003640.1
CDS	208..1425
Translation	MDSGARSKSSRDLKIHRPENEKVSAAGPKRVPVTQSVQKPVSNPHTRVLGAAQGPQRVQRPVGKTSCPGDQNTRPEQHKPAAHSKPQPKPPLSAETNKTAEPSKQDKPHQTPSSTTSTSSNTSGSSKSSKKAWTLENFDIGRALGKGKFGSVYLAREQQTKFILALKVLFKKQLEKAGVEHQLRREVEIQSHLRHPNILRLYGYFHDAARVYLILEFAPKGELYGELQRCGTFDDQRSATYIMELADALRYCHSKAVIHRDIKPENLLLGANGELKIADFGWSVHTPSSRRSTLCGTLDYLPPEMIEGKTHDEKVDLWSLGVLCYEFLVGRPPFETKSHEETYRKISRVEFTYPAHVSNGSRDLINRLLKHNPMHRLPIQGVMEHPWVVENSTKKPTTYTATANN

Target ORF information:

RefSeq Version	NM_001003640.2
Organism	Danio rerio(zebrafish)
Definition	Danio rerio aurora kinase A (aurka), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001003640.2

ORF Insert Sequence:

ATGGACTCTG GTGCAAGAAG CAAATCAAGC AGAGATCTGA AGATTCATCG ACCTGAAAAT 
GAGAAGGTTT CTGCCGCTGG ACCCAAAAGA GTTCCTGTAA CCCAGAGCGT GCAGAAGCCA 
GTGTCGAACC CACACACGCG TGTTCTCGGC GCTGCACAGG GACCACAGCG TGTCCAACGT 
CCTGTTGGGA AAACCTCTTG TCCTGGAGAC CAGAACACCC GTCCAGAACA GCACAAACCA 
GCAGCGCACA GCAAACCACA GCCAAAACCA CCGCTGTCAG CGGAGACCAA CAAAACTGCA 
GAACCCAGCA AACAGGATAA ACCTCACCAA ACTCCTTCCA GTACTACTTC TACCTCCTCC 
AACACCAGTG GATCATCGAA GAGTTCAAAA AAAGCCTGGA CTTTGGAGAA TTTCGACATT 
GGCCGCGCTC TGGGCAAGGG GAAGTTTGGC AGCGTGTATC TGGCCAGAGA ACAGCAGACC 
AAGTTTATTC TGGCGCTCAA AGTTCTGTTC AAGAAGCAGC TGGAGAAAGC AGGAGTGGAG 
CATCAGCTGC GCAGGGAGGT GGAGATACAG TCACATCTCA GACATCCCAA TATCCTGCGT 
TTGTATGGTT ATTTCCACGA CGCGGCCCGT GTTTACCTCA TCCTAGAGTT TGCTCCTAAA 
GGAGAGCTGT ATGGAGAACT GCAGCGCTGC GGGACGTTCG ATGACCAGAG AAGCGCCACG 
TATATAATGG AGTTGGCGGA TGCTCTGAGA TACTGCCACT CGAAGGCTGT GATCCACAGA 
GATATTAAAC CTGAAAACCT GCTGCTGGGA GCCAATGGAG AGCTGAAGAT TGCAGATTTT 
GGCTGGTCCG TCCACACGCC CTCCTCCAGG AGGTCGACGC TGTGCGGCAC ACTGGACTAT 
CTTCCTCCAG AGATGATTGA AGGTAAAACA CATGATGAGA AGGTGGATCT CTGGAGTCTT 
GGAGTGCTCT GCTATGAGTT TCTGGTTGGC AGGCCACCTT TTGAAACAAA GAGTCATGAA 
GAGACGTACC GCAAGATTTC TAGAGTTGAG TTTACTTATC CAGCTCATGT GAGCAACGGC 
AGCAGAGACC TGATCAATCG ACTACTCAAG CACAACCCAA TGCACAGACT CCCCATCCAG 
GGAGTAATGG AGCACCCGTG GGTTGTGGAA AACTCCACCA AGAAACCAAC CACTTACACC 
GCCACCGCCA ACAACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Rosmarinic acid plays a protective role in the embryogenesis of zebrafish exposed to food colours through its influence on aurora kinase A level.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie891166-1171(2017 May)
Swarnalatha Y,Jerrine Joseph IS,Jayakrishna T

RFX transcription factors are essential for hearing in mice.
Nature communications68549(2015 Oct)
Elkon R,Milon B,Morrison L,Shah M,Vijayakumar S,Racherla M,Leitch CC,Silipino L,Hadi S,Weiss-Gayet M,Barras E,Schmid CD,Ait-Lounis A,Barnes A,Song Y,Eisenman DJ,Eliyahu E,Frolenkov GI,Strome SE,Durand B,Zaghloul NA,Jones SM,Reith W,Hertzano R

Early depletion of primordial germ cells in zebrafish promotes testis formation.
Stem cell reports4(1)61-73(2015 Jan)
Tzung KW,Goto R,Saju JM,Sreenivasan R,Saito T,Arai K,Yamaha E,Hossain MS,Calvert ME,Orb?n L

Microtubule-associated protein 9 (Map9/Asap) is required for the early steps of zebrafish development.
Cell cycle (Georgetown, Tex.)13(7)1101-14(2014)
Fontenille L,Rouquier S,Lutfalla G,Giorgi D

Depletion of Aurora-A in zebrafish causes growth retardation due to mitotic delay and p53-dependent cell death.
The FEBS journal280(6)1518-30(2013 Mar)
Jeon HY,Lee H