ddc cDNA ORF clone, Danio rerio(zebrafish)

Gene
Clones
gRNAs

Summary

Gene Symbol	ddc
Entrez Gene ID	406651
Full Name	dopa decarboxylase
Synonyms	wu:fa56d05,wu:fd59h03,wu:fk20h01,zgc:65801,zgc:76929
General protein information	Preferred Names dopa decarboxylase Names aromatic-L-amino-acid decarboxylase aromatic amino acid decarboxylase
Gene Type	protein-coding
Organism	Danio rerio(zebrafish)

mRNA and Protein(s)

mRNA	Protein	Name
NM_213342.1	NP_998507.1	aromatic-L-amino-acid decarboxylase

Pathways from BioSystems

Homologies

	DDC	XP_001082132.1
Mus musculus (house mouse)	Ddc	NP_001177377.1
Rattus norvegicus (Norway rat)	Ddc	NP_036677.1
Danio rerio (zebrafish)	ddc	NP_998507.1
Homo sapiens (human)	DDC	NP_000781.1
Bos taurus (cattle)	DDC	NP_776332.1
Gallus gallus (chicken)	DDC	XP_419032.3
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP009091	XP_319841.3
Arabidopsis thaliana (thale cress)	AT2G20340	NP_849999.1
Oryza sativa (rice)	Os07g0437500	NP_001059509.1
Drosophila melanogaster (fruit fly)	Ddc	NP_724163.1
Pan troglodytes (chimpanzee)	DDC	XP_519096.2
Canis lupus familiaris (dog)	DDC	XP_848285.2
Neurospora crassa	NCU08275	XP_961903.1
Xenopus tropicalis (tropical clawed frog)	ddc	NP_001011289.1

Gene Ontology
Bibliography

Related articles in PubMed

Knockout of histamine receptor H3 alters adaptation to sudden darkness and monoamine levels in the zebrafish.
Puttonen HAJ, Sundvik M, Semenova S, Shirai Y, Chen YC, Panula P
Acta physiologica (Oxford, England)(2017 Oct)

Embryonic Atrazine Exposure Elicits Alterations in Genes Associated with Neuroendocrine Function in Adult Male Zebrafish.
Wirbisky SE, Sep?lveda MS, Weber GJ, Jannasch AS, Horzmann KA, Freeman JL
Toxicological sciences : an official journal of the Society of Toxicology153(1)149-64(2016 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Loss of Ddc appears to result in similar phenotypes as that of ADCC deficiency, thus zebrafish could be a good model for investigating pathogenetic mechanisms of AADC deficiency in children.
Title: Aromatic L-amino acid decarboxylase (AADC) is crucial for brain development and motor functions.

The following ddc gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ddc cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ODa01173	NM_213342.1 Latest version!	Danio rerio dopa decarboxylase (ddc), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$258.30 $369.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

ddc ( NM_213342.1 ) cDNA ORF clone, Danio rerio(zebrafish) -> NP_998507.1 Danio rerio dopa decarboxylase (ddc), mRNA.

Price & Availability↑

CloneID	ODa01173
Clone ID Related Accession (Same CDS sequence)	NM_213342.1
Accession Version	NM_213342.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1443bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-22
Organism	Danio rerio(zebrafish)
Product	aromatic-L-amino-acid decarboxylase
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC056292.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC056292.1, BC068188.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA2168446, SAMEA2168447 [ECO:0000350] ##Evidence-Data-END##

ATGGATGCCG CAGAGTTTCG GAGACGCGGG AGGGAGATGG TTGATTATGT GGCGGATTAT 
ATAGAGAACA TTGAGAAAAG GCAGGTTTAC CCTGATGTGG AACCGGGATA TCTGAGGTCA 
CTGATTCCTG AGGAGGCCCC GGAGGAGCCA GAGAGCTATG AGGATGTGGT CAAAGACATC 
GAGAGGGTGA TCATGCCAGG GGTCACCCAC TGGCACAGCC CATACTTCTA TGCATATTTT 
CCCACTGCCC ACTCTTATCC TGCAATGCTC GCAGACATAC TGTGTGGAGC CATTGGCTGC 
ATTGGATTCT CTTGGGCTGC AAGTCCTGCC TGTACGGAGC TAGAGACAGT GATGCTGGAC 
TGGCTGGGAA AGATGCTGAA ACTACCGGAA GATTTTCTTG CTGGGACCAA AGGCAAAGGA 
GGTGGGGTCA TCCAGAGCAC TGCCAGTGAA GCCACTCTCA TAACCCTTCT TGCTGCTCGC 
TCCAAAATCG TCAGGCTGAT CCAGGCGGAC CATCCTGACC GATCTGAGAC TGACATTATA 
TCCAAACTAG TTGCCTATTC ATCTGATCAG GCACACTCAT CGGTGGAGAG GGCAGGGTTG 
ATAGGTGGAG TGAGAATGAA GAAAATTCCT ACCGACAGCA AGTTTTCTGT GCGAGGAGAT 
GCACTGGAGA GGATCCTGAA GGAGGATAAA GCTGCTGGAC TTATACCATT TTTTTTCTGT 
GCAACACTGG GAACAACTGC ATCCTGTGCA TTCGACTGCA TCACTGAGCT GGGCCCTATA 
TGCAATGCAG AGAAAATGTG GATGCACATC GATGCTGCAT ATGCCGGGAG TGCTTTTATC 
TGTCCGGAGT TCAGACCCCT GCTGAACGGC ATTGAGTTTG CAGACTCTTT CAATTTCAAT 
CCTCATAAAT GGCTCCTGAT CAACTTTGAT TGCTCGGCGA TGTGGGTAAA GAAAAGAGCA 
GACATTATTG GAGCATTTAA AATGGAGCCA CTTTATCTAA AGCATGATCA CCAAGAGTCA 
GGACTTGTCA CTGATTATAG ACACTGGCAG ATCCCGCTGG GTCGGAGGTT TCGCTCTCTC 
AAAATGTGGT TTGTGTTCCG CATGTACGGA CTCAAAGCTC TCCAAGCCTA CATCCGCAAG 
CATGTAGGAC TGGCTAAAGA GTTCGAGGCT TTCGTGAGAG CTGATCAACG CTTTGAGATC 
TCAGCTGATG TGGTGATGGG TCTCGTCTGC TTTAGACTCA AGGGCCCCAA TGAATTAAGT 
GAAAATCTGC TGAAGAGGAT CAACAGCGCA CGGAAGATTC ATCTGGTTCC TTGCCACCTG 
GCTGGCCTGT TTGTTCTGCG GTTTGCCGTG TGTGCCCGCG CTACTGAGTC ACGGCATGTC 
CAGGAGGCCT GGTGCCACAT CCGTCAGCTG GCATCAGAGC TGCTTCAGGA ACTGCTACAC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_998507.1
CDS	111..1553
Translation	MDAAEFRRRGREMVDYVADYIENIEKRQVYPDVEPGYLRSLIPEEAPEEPESYEDVVKDIERVIMPGVTHWHSPYFYAYFPTAHSYPAMLADILCGAIGCIGFSWAASPACTELETVMLDWLGKMLKLPEDFLAGTKGKGGGVIQSTASEATLITLLAARSKIVRLIQADHPDRSETDIISKLVAYSSDQAHSSVERAGLIGGVRMKKIPTDSKFSVRGDALERILKEDKAAGLIPFFFCATLGTTASCAFDCITELGPICNAEKMWMHIDAAYAGSAFICPEFRPLLNGIEFADSFNFNPHKWLLINFDCSAMWVKKRADIIGAFKMEPLYLKHDHQESGLVTDYRHWQIPLGRRFRSLKMWFVFRMYGLKALQAYIRKHVGLAKEFEAFVRADQRFEISADVVMGLVCFRLKGPNELSENLLKRINSARKIHLVPCHLAGLFVLRFAVCARATESRHVQEAWCHIRQLASELLQELLH

Target ORF information:

RefSeq Version	NM_213342.1
Organism	Danio rerio(zebrafish)
Definition	Danio rerio dopa decarboxylase (ddc), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_213342.1

ORF Insert Sequence:

ATGGATGCCG CAGAGTTTCG GAGACGCGGG AGGGAGATGG TTGATTATGT GGCGGATTAT 
ATAGAGAACA TTGAGAAAAG GCAGGTTTAC CCTGATGTGG AACCGGGATA TCTGAGGTCA 
CTGATTCCTG AGGAGGCCCC GGAGGAGCCA GAGAGCTATG AGGATGTGGT CAAAGACATC 
GAGAGGGTGA TCATGCCAGG GGTCACCCAC TGGCACAGCC CATACTTCTA TGCATATTTT 
CCCACTGCCC ACTCTTATCC TGCAATGCTC GCAGACATAC TGTGTGGAGC CATTGGCTGC 
ATTGGATTCT CTTGGGCTGC AAGTCCTGCC TGTACGGAGC TAGAGACAGT GATGCTGGAC 
TGGCTGGGAA AGATGCTGAA ACTACCGGAA GATTTTCTTG CTGGGACCAA AGGCAAAGGA 
GGTGGGGTCA TCCAGAGCAC TGCCAGTGAA GCCACTCTCA TAACCCTTCT TGCTGCTCGC 
TCCAAAATCG TCAGGCTGAT CCAGGCGGAC CATCCTGACC GATCTGAGAC TGACATTATA 
TCCAAACTAG TTGCCTATTC ATCTGATCAG GCACACTCAT CGGTGGAGAG GGCAGGGTTG 
ATAGGTGGAG TGAGAATGAA GAAAATTCCT ACCGACAGCA AGTTTTCTGT GCGAGGAGAT 
GCACTGGAGA GGATCCTGAA GGAGGATAAA GCTGCTGGAC TTATACCATT TTTTTTCTGT 
GCAACACTGG GAACAACTGC ATCCTGTGCA TTCGACTGCA TCACTGAGCT GGGCCCTATA 
TGCAATGCAG AGAAAATGTG GATGCACATC GATGCTGCAT ATGCCGGGAG TGCTTTTATC 
TGTCCGGAGT TCAGACCCCT GCTGAACGGC ATTGAGTTTG CAGACTCTTT CAATTTCAAT 
CCTCATAAAT GGCTCCTGAT CAACTTTGAT TGCTCGGCGA TGTGGGTAAA GAAAAGAGCA 
GACATTATTG GAGCATTTAA AATGGAGCCA CTTTATCTAA AGCATGATCA CCAAGAGTCA 
GGACTTGTCA CTGATTATAG ACACTGGCAG ATCCCGCTGG GTCGGAGGTT TCGCTCTCTC 
AAAATGTGGT TTGTGTTCCG CATGTACGGA CTCAAAGCTC TCCAAGCCTA CATCCGCAAG 
CATGTAGGAC TGGCTAAAGA GTTCGAGGCT TTCGTGAGAG CTGATCAACG CTTTGAGATC 
TCAGCTGATG TGGTGATGGG TCTCGTCTGC TTTAGACTCA AGGGCCCCAA TGAATTAAGT 
GAAAATCTGC TGAAGAGGAT CAACAGCGCA CGGAAGATTC ATCTGGTTCC TTGCCACCTG 
GCTGGCCTGT TTGTTCTGCG GTTTGCCGTG TGTGCCCGCG CTACTGAGTC ACGGCATGTC 
CAGGAGGCCT GGTGCCACAT CCGTCAGCTG GCATCAGAGC TGCTTCAGGA ACTGCTACAC 
TGA