LMAN2 cDNA ORF clone, Canis lupus familiaris(dog)

Gene
Clones
gRNAs

Summary

Gene Symbol	LMAN2
Entrez Gene ID	403938
Full Name	lectin, mannose binding 2
Synonyms	VIP36
General protein information	Preferred Names lectin, mannose binding 2 Names vesicular integral-membrane protein VIP36 vesicular integral-membrane protein 36
Gene Type	protein-coding
Organism	Canis lupus familiaris(dog)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001003258.2	NP_001003258.1	vesicular integral-membrane protein VIP36 precursor
XM_022417332.1	XP_022273040.1	vesicular integral-membrane protein VIP36 isoform X1

Pathways from BioSystems

Homologies

Homo sapiens (human)	LMAN2	NP_006807.1
Pan troglodytes (chimpanzee)	LMAN2	XP_001141238.1
Gallus gallus (chicken)	LMAN2	XP_003642101.2
Danio rerio (zebrafish)	lman2	NP_001075216.2
Canis lupus familiaris (dog)	LMAN2	NP_001003258.1
Mus musculus (house mouse)	Lman2	NP_080104.2
Bos taurus (cattle)	LMAN2	NP_001094779.1
Xenopus tropicalis (tropical clawed frog)	lman2	NP_001072196.1
Rattus norvegicus (Norway rat)	Lman2	NP_001108496.1

Gene Ontology
Bibliography

Related articles in PubMed

Adaptor Protein CD2AP and L-type Lectin LMAN2 Regulate Exosome Cargo Protein Trafficking through the Golgi Complex.
Kwon SH, Oh S, Nacke M, Mostov KE, Lipschutz JH
The Journal of biological chemistry291(49)25462-25475(2016 Dec)

Use of fluorescence-activated vesicle sorting for isolation of Naked2-associated, basolaterally targeted exocytic vesicles for proteomics analysis.
Cao Z, Li C, Higginbotham JN, Franklin JL, Tabb DL, Graves-Deal R, Hill S, Cheek K, Jerome WG, Lapierre LA, Goldenring JR, Ham AJ, Coffey RJ
Molecular & cellular proteomics : MCP7(9)1651-67(2008 Sep)

Structural basis for recognition of high mannose type glycoproteins by mammalian transport lectin VIP36.
Satoh T, Cowieson NP, Hakamata W, Ideo H, Fukushima K, Kurihara M, Kato R, Yamashita K, Wakatsuki S
The Journal of biological chemistry282(38)28246-55(2007 Sep)

Involvement of VIP36 in intracellular transport and secretion of glycoproteins in polarized Madin-Darby canine kidney (MDCK) cells.
Hara-Kuge S, Ohkura T, Ideo H, Shimada O, Atsumi S, Yamashita K
The Journal of biological chemistry277(18)16332-9(2002 May)

VIP36 localisation to the early secretory pathway.
F?llekrug J, Scheiffele P, Simons K
Journal of cell science112 ( Pt 17)2813-21(1999 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

data thus reveal a Golgi-traversing pathway for exosomal release of the cargo protein GPRC5B in which CD2AP facilitates the entry and LMAN2 impedes the exit of the flux, respectively.
Title: Adaptor Protein CD2AP and L-type Lectin LMAN2 Regulate Exosome Cargo Protein Trafficking through the Golgi Complex.

The following LMAN2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the LMAN2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OCe00293	NM_001003258.2 Latest version!	Canis lupus familiaris lectin, mannose binding 2 (LMAN2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$258.30 $369.00
OCe287445	XM_022417332.1 Latest version!	Canis lupus familiaris lectin, mannose binding 2 (LMAN2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$174.30 $249.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

LMAN2 ( NM_001003258.2 ) cDNA ORF clone, Canis lupus familiaris(dog) -> NP_001003258.1 Canis lupus familiaris lectin, mannose binding 2 (LMAN2), mRNA.

Price & Availability↑

CloneID	OCe00293
Clone ID Related Accession (Same CDS sequence)	NM_001003258.2
Accession Version	NM_001003258.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1071bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-22
Organism	Canis lupus familiaris(dog)
Product	vesicular integral-membrane protein VIP36 precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from X76392.1. On Aug 31, 2012 this sequence version replaced NM_001003258.1. ##Evidence-Data-START## Transcript exon combination :: X76392.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103936001, SAMEA103936002 [ECO:0000348] ##Evidence-Data-END##

ATGGCGGCGG AAGGCTGGAT TTGGCGCTGG GGCTGGGGCC GGCGGTGCCT GGGGAGGCCT 
GGGCTTCCCG GCCCCGGCCC TGGCCCCGCT ACACCTCTAT TTCTTCTCCT GTTGCTGGGG 
CCGGTTGTTG CTGATATAAC TGACGGTAAC AGTGAACACC TCAAGCGGGA GCATTCGCTT 
ATCAAGCCCT ACCAAGGGGT CGGTTCCAGC TCCATGCCCC TCTGGGACTT TCAAGGCAGC 
ACTATACTCA CGAGCCAGTA CGTGCGTTTG ACCCCGGATG AGCGCAGCAA AGAGGGCTCT 
ATCTGGAACC ACCAGCCTTG TTTCCTCAAG GACTGGGAGA TGCACGTCCA CTTTAAAGTC 
CATGGTACGG GGAAGAAAAA TCTCCATGGA GACGGCATTG CCTTGTGGTA CACCCGGGAC 
CGCCTTGTGC CAGGGCCTGT GTTTGGAAGC AAAGACAACT TCCATGGCTT AGCCATCTTC 
TTGGACACGT ATCCCAATGA TGAGACCACG GAGCGTGTGT TCCCGTACAT CTCGGTGATG 
GTGAACAATG GCTCCCTGTC CTACGACCAT AGCAAAGATG GCCGCTGGAC GGAGCTGGCA 
GGCTGCACGG CTGACTTCCG TAACCGTGAT CATGATACCT TCCTAGCTGT GCGCTACTCT 
CGGGGCCGGC TGACGGTAAT GACTGACCTA GAGGACAAGA ATGAGTGGAA GAATTGCATT 
GACATCACGG GAGTGCGCCT GCCCACTGGT TACTACTTTG GAGCCTCAGC TGGCACTGGT 
GACCTGTCTG ACAATCATGA CATCATTTCC ATGAAGCTGT TCCAGCTGAT GGTAGAACAC 
ACGCCTGACG AAGAGAACAT TGACTGGACC AAGATTGAGC CCAGTGTCAA TTTCCTCAAG 
TCACCCAAAG ACAATGTGGA TGACCCGACT GGAAACTTCC GAAGTGGGCC CCTGACCGGG 
TGGCGGGTGT TCCTGCTGCT GCTGTGTGCA CTCTTGGGCA TCATCGTGTG CGCTGTGGTG 
GGGGCCGTAG TGTTTCAGAA GCGGCAGGAG CGGAACAAGC GTTTCTACTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001003258.1
CDS	30..1100
Translation	MAAEGWIWRWGWGRRCLGRPGLPGPGPGPATPLFLLLLLGPVVADITDGNSEHLKREHSLIKPYQGVGSSSMPLWDFQGSTILTSQYVRLTPDERSKEGSIWNHQPCFLKDWEMHVHFKVHGTGKKNLHGDGIALWYTRDRLVPGPVFGSKDNFHGLAIFLDTYPNDETTERVFPYISVMVNNGSLSYDHSKDGRWTELAGCTADFRNRDHDTFLAVRYSRGRLTVMTDLEDKNEWKNCIDITGVRLPTGYYFGASAGTGDLSDNHDIISMKLFQLMVEHTPDEENIDWTKIEPSVNFLKSPKDNVDDPTGNFRSGPLTGWRVFLLLLCALLGIIVCAVVGAVVFQKRQERNKRFY

Target ORF information:

RefSeq Version	NM_001003258.2
Organism	Canis lupus familiaris(dog)
Definition	Canis lupus familiaris lectin, mannose binding 2 (LMAN2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001003258.2

ORF Insert Sequence:

ATGGCGGCGG AAGGCTGGAT TTGGCGCTGG GGCTGGGGCC GGCGGTGCCT GGGGAGGCCT 
GGGCTTCCCG GCCCCGGCCC TGGCCCCGCT ACACCTCTAT TTCTTCTCCT GTTGCTGGGG 
CCGGTTGTTG CTGATATAAC TGACGGTAAC AGTGAACACC TCAAGCGGGA GCATTCGCTT 
ATCAAGCCCT ACCAAGGGGT CGGTTCCAGC TCCATGCCCC TCTGGGACTT TCAAGGCAGC 
ACTATACTCA CGAGCCAGTA CGTGCGTTTG ACCCCGGATG AGCGCAGCAA AGAGGGCTCT 
ATCTGGAACC ACCAGCCTTG TTTCCTCAAG GACTGGGAGA TGCACGTCCA CTTTAAAGTC 
CATGGTACGG GGAAGAAAAA TCTCCATGGA GACGGCATTG CCTTGTGGTA CACCCGGGAC 
CGCCTTGTGC CAGGGCCTGT GTTTGGAAGC AAAGACAACT TCCATGGCTT AGCCATCTTC 
TTGGACACGT ATCCCAATGA TGAGACCACG GAGCGTGTGT TCCCGTACAT CTCGGTGATG 
GTGAACAATG GCTCCCTGTC CTACGACCAT AGCAAAGATG GCCGCTGGAC GGAGCTGGCA 
GGCTGCACGG CTGACTTCCG TAACCGTGAT CATGATACCT TCCTAGCTGT GCGCTACTCT 
CGGGGCCGGC TGACGGTAAT GACTGACCTA GAGGACAAGA ATGAGTGGAA GAATTGCATT 
GACATCACGG GAGTGCGCCT GCCCACTGGT TACTACTTTG GAGCCTCAGC TGGCACTGGT 
GACCTGTCTG ACAATCATGA CATCATTTCC ATGAAGCTGT TCCAGCTGAT GGTAGAACAC 
ACGCCTGACG AAGAGAACAT TGACTGGACC AAGATTGAGC CCAGTGTCAA TTTCCTCAAG 
TCACCCAAAG ACAATGTGGA TGACCCGACT GGAAACTTCC GAAGTGGGCC CCTGACCGGG 
TGGCGGGTGT TCCTGCTGCT GCTGTGTGCA CTCTTGGGCA TCATCGTGTG CGCTGTGGTG 
GGGGCCGTAG TGTTTCAGAA GCGGCAGGAG CGGAACAAGC GTTTCTACTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

LMAN2 ( XM_022417332.1 ) cDNA ORF clone, Canis lupus familiaris(dog) -> XP_022273040.1 Canis lupus familiaris lectin, mannose binding 2 (LMAN2), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OCe287445
Clone ID Related Accession (Same CDS sequence)	XM_022417332.1
Accession Version	XM_022417332.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 933bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-04
Organism	Canis lupus familiaris(dog)
Product	vesicular integral-membrane protein VIP36 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_006586.3) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Canis lupus familiaris Annotation Release 105 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.4 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCGGCGG AAGGCTGGAT TTGGCGCTGG GGCTGGGGCC GGCGGTGCCT GGGGAGGCCT 
GGGCTTCCCG GCCCCGGCCC TGGCCCCGCT ACACCTCTAT TTCTTCTCCT GTTGCTGGGG 
CCGGTTGTTG CTGATATAAC TGACGGTAAC AGTGAACACC TCAAGCGGGA GCATTCGCTT 
ATCAAGCCCT ACCAAGGGGT CGGTTCCAGC TCCATGCCCC TCTGGGACTT TCAAGGCAGC 
ACTATACTCA CGAGCCAGTA CGTGCGTTTG ACCCCGGATG AGCGCAGCAA AGAGGGCTCT 
ATCTGGAACC ACCAGCCTTG TTTCCTCAAG GACTGGGAGA TGCACGTCCA CTTTAAAGTC 
CATGGTACGG GGAAGAAAAA TCTCCATGGA GACGGCATTG CCTTGTGGTA CACCCGGGAC 
CGCCTTGTGC CAGGGCCTGT GTTTGGAAGC AAAGACAACT TCCATGGCTT AGCCATCTTC 
TTGGACACGT ATCCCAATGA TGAGACCACG GAGCGTGTGT TCCCGTACAT CTCGGTGATG 
GTGAACAATG GCTCCCTGTC CTACGACCAT AGCAAAGATG GCCGCTGGAC GGAGCTGGCA 
GGCTGCACGG CTGACTTCCG TAACCGTGAT CATGATACCT TCCTAGCTGT GCGCTACTCT 
CGGGGCCGGC TGACGGTAAT GACTGACCTA GAGGACAAGA ATGAGTGGAA GAATTGCATT 
GACATCACGG GAGTGCGCCT GCCCACTGGT TACTACTTTG GAGCCTCAGC TGGCACTGGT 
GACCTGTCTG ACAATCATGA CATCATTTCC ATGAAGCTGT TCCAGCTGAT GGTAGAACAC 
ACGCCTGACG AAGAGAACAT TGACTGGACC AAGATTGAGC CCAGTGTCAA TTTCCTCAAG 
TCACCCAAAG AACAAGGGCT CTGGCTGAAG TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_022273040.1
CDS	187..1119
Translation	MAAEGWIWRWGWGRRCLGRPGLPGPGPGPATPLFLLLLLGPVVADITDGNSEHLKREHSLIKPYQGVGSSSMPLWDFQGSTILTSQYVRLTPDERSKEGSIWNHQPCFLKDWEMHVHFKVHGTGKKNLHGDGIALWYTRDRLVPGPVFGSKDNFHGLAIFLDTYPNDETTERVFPYISVMVNNGSLSYDHSKDGRWTELAGCTADFRNRDHDTFLAVRYSRGRLTVMTDLEDKNEWKNCIDITGVRLPTGYYFGASAGTGDLSDNHDIISMKLFQLMVEHTPDEENIDWTKIEPSVNFLKSPKEQGLWLK

Target ORF information:

RefSeq Version	XM_022417332.1
Organism	Canis lupus familiaris(dog)
Definition	Canis lupus familiaris lectin, mannose binding 2 (LMAN2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_022417332.1

ORF Insert Sequence:

ATGGCGGCGG AAGGCTGGAT TTGGCGCTGG GGCTGGGGCC GGCGGTGCCT GGGGAGGCCT 
GGGCTTCCCG GCCCCGGCCC TGGCCCCGCT ACACCTCTAT TTCTTCTCCT GTTGCTGGGG 
CCGGTTGTTG CTGATATAAC TGACGGTAAC AGTGAACACC TCAAGCGGGA GCATTCGCTT 
ATCAAGCCCT ACCAAGGGGT CGGTTCCAGC TCCATGCCCC TCTGGGACTT TCAAGGCAGC 
ACTATACTCA CGAGCCAGTA CGTGCGTTTG ACCCCGGATG AGCGCAGCAA AGAGGGCTCT 
ATCTGGAACC ACCAGCCTTG TTTCCTCAAG GACTGGGAGA TGCACGTCCA CTTTAAAGTC 
CATGGTACGG GGAAGAAAAA TCTCCATGGA GACGGCATTG CCTTGTGGTA CACCCGGGAC 
CGCCTTGTGC CAGGGCCTGT GTTTGGAAGC AAAGACAACT TCCATGGCTT AGCCATCTTC 
TTGGACACGT ATCCCAATGA TGAGACCACG GAGCGTGTGT TCCCGTACAT CTCGGTGATG 
GTGAACAATG GCTCCCTGTC CTACGACCAT AGCAAAGATG GCCGCTGGAC GGAGCTGGCA 
GGCTGCACGG CTGACTTCCG TAACCGTGAT CATGATACCT TCCTAGCTGT GCGCTACTCT 
CGGGGCCGGC TGACGGTAAT GACTGACCTA GAGGACAAGA ATGAGTGGAA GAATTGCATT 
GACATCACGG GAGTGCGCCT GCCCACTGGT TACTACTTTG GAGCCTCAGC TGGCACTGGT 
GACCTGTCTG ACAATCATGA CATCATTTCC ATGAAGCTGT TCCAGCTGAT GGTAGAACAC 
ACGCCTGACG AAGAGAACAT TGACTGGACC AAGATTGAGC CCAGTGTCAA TTTCCTCAAG 
TCACCCAAAG AACAAGGGCT CTGGCTGAAG TGA