| Gene Symbol | jnk-1 |
| Entrez Gene ID | 177460 |
| Full Name | Stress-activated protein kinase jnk-1 |
| Gene Type | protein-coding |
| Organism | Caenorhabditis elegans |
ORF » Species Summary » Caenorhabditis elegans » jnk-1 cDNA ORF clone
| Gene Symbol | jnk-1 |
| Entrez Gene ID | 177460 |
| Full Name | Stress-activated protein kinase jnk-1 |
| Gene Type | protein-coding |
| Organism | Caenorhabditis elegans |
| mRNA | Protein | Name |
|---|---|---|
| NM_171371.4 | NP_741434.2 | Stress-activated protein kinase jnk-1 |
| NM_171371.5 | NP_741434.2 | Stress-activated protein kinase jnk-1 |
| NM_001026099.3 | NP_001021270.1 | Stress-activated protein kinase jnk-1 |
| NM_001026099.4 | NP_001021270.1 | Stress-activated protein kinase jnk-1 |
| MAPK8 | XP_001108815.1 | |
| Canis lupus familiaris (dog) | MAPK8 | XP_005637524.1 |
| Rattus norvegicus (Norway rat) | Mapk8 | NP_446281.1 |
| Xenopus tropicalis (tropical clawed frog) | mapk8 | NP_001123415.1 |
| Homo sapiens (human) | MAPK8 | NP_001265476.1 |
| Bos taurus (cattle) | MAPK8 | NP_001179903.1 |
| Anopheles gambiae (African malaria mosquito) | AgaP_AGAP009461 | XP_310236.3 |
| Pan troglodytes (chimpanzee) | MAPK8 | XP_001136927.1 |
| Gallus gallus (chicken) | MAPK8 | XP_001233169.1 |
| Danio rerio (zebrafish) | mapk8a | NP_001103859.1 |
| Drosophila melanogaster (fruit fly) | bsk | NP_001162930.1 |
| Caenorhabditis elegans (roundworm) | jnk-1 | NP_001021270.1 |
| Mus musculus (house mouse) | Mapk8 | NP_057909.1 |
Genome sequence of the nematode C. elegans: a platform for investigating biology.
Science (New York, N.Y.)282(5396)2012-8(1998 Dec)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Our genetic study unravelled the underlying pathway where JNK-1 is acting independently of insulin-IGF-1 signalling (IIS) pathway to modulate longevity. In support of in vivo results in silico docking study of UA with C. elegans JNK-1 ATP-binding site suggested promising binding affinity exhibiting binding energy of -8.11 kcalmol(-1). UA induced JNK-1 activation in wild-type animals underlie the importance of pharmacologi
Title: 3?-Hydroxy-urs-12-en-28-oic acid prolongs lifespan in C.?elegans by modulating JNK-1.
the stress response is controlled by a c-Jun N-terminal kinase (JNK)-like mitogen-activated protein kinase (MAPK) signaling pathway, which is regulated by MLK-1 MAPK kinase kinase (MAPKKK), MEK-1 MAPK kinase (MAPKK), and KGB-1 JNK-like MAPK.
Title: Role of the Caenorhabditis elegans Shc adaptor protein in the c-Jun N-terminal kinase signaling pathway.
The present study shows in Caenorhabditis elegans that ambient temperature (1-37 degrees C) specifically influences the activation (phosphorylation) of the MAP kinase JNK-1 as well as the nuclear translocation of DAF-16.
Title: The MAP kinase JNK-1 of Caenorhabditis elegans: location, activation, and influences over temperature-dependent insulin-like signaling, stress responses, and fitness.
JNK-1 directly interacts with and phosphorylates DAF-16. Moreover, in response to heat stress, JNK-1 promotes the translocation of DAF-16 into the nucleus.
Title: JNK regulates lifespan in Caenorhabditis elegans by modulating nuclear translocation of forkhead transcription factor/DAF-16.
The following jnk-1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the jnk-1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
| CloneID | OCa343309 | |
| Clone ID Related Accession (Same CDS sequence) | NM_001026099.3 , NM_001026099.4 | |
| Accession Version | NM_001026099.3 | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 1392bp) Protein sequence SNP |
|
| Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-04-08 | |
| Organism | Caenorhabditis elegans | |
| Product | Stress-activated protein kinase jnk-1 | |
| Comment | Comment: REVIEWED REFSEQ: This record has been curated by WormBase. This record is derived from an annotated genomic sequence (NC_003282). On Jun 26, 2012 this sequence version replaced NM_001026099.2. COMPLETENESS: incomplete on both ends. | |
1 | ATGGAGGAAC GATTATCCAC AACATCATCG TATCCGTCAC ATCCAGGTAG AAGCGTGGAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_001021270.1 |
| CDS | 1..1392 |
| Translation |
Target ORF information:
Target ORF information:
|
NM_001026099.3 |
1 | ATGGAGGAAC GATTATCCAC AACATCATCG TATCCGTCAC ATCCAGGTAG AAGCGTGGAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | OCa343309 | |
| Clone ID Related Accession (Same CDS sequence) | NM_001026099.3 , NM_001026099.4 | |
| Accession Version | NM_001026099.4 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 1392bp) Protein sequence SNP |
|
| Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-10-17 | |
| Organism | Caenorhabditis elegans | |
| Product | Stress-activated protein kinase jnk-1 | |
| Comment | Comment: REVIEWED REFSEQ: This record has been curated by WormBase. This record is derived from an annotated genomic sequence (NC_003282). On Sep 4, 2019 this sequence version replaced NM_001026099.3. | |
1 | ATGGAGGAAC GATTATCCAC AACATCATCG TATCCGTCAC ATCCAGGTAG AAGCGTGGAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_001021270.1 |
| CDS | 37..1428 |
| Translation |
Target ORF information:
Target ORF information:
|
NM_001026099.4 |
1 | ATGGAGGAAC GATTATCCAC AACATCATCG TATCCGTCAC ATCCAGGTAG AAGCGTGGAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | OCa343310 | |
| Clone ID Related Accession (Same CDS sequence) | NM_171371.4 , NM_171371.5 | |
| Accession Version | NM_171371.4 | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 1119bp) Protein sequence SNP |
|
| Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-04-08 | |
| Organism | Caenorhabditis elegans | |
| Product | Stress-activated protein kinase jnk-1 | |
| Comment | Comment: REVIEWED REFSEQ: This record has been curated by WormBase. This record is derived from an annotated genomic sequence (NC_003282). On Jun 26, 2012 this sequence version replaced NM_171371.3. COMPLETENESS: incomplete on both ends. | |
1 | ATGGAACCAT CCTCTATTCA TGTTCCCGAA AACTATTATT CGGTGACAAT AGGGGAAGCG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_741434.2 |
| CDS | 1..1119 |
| Translation |
Target ORF information:
Target ORF information:
|
NM_171371.4 |
1 | ATGGAACCAT CCTCTATTCA TGTTCCCGAA AACTATTATT CGGTGACAAT AGGGGAAGCG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | OCa343310 | |
| Clone ID Related Accession (Same CDS sequence) | NM_171371.4 , NM_171371.5 | |
| Accession Version | NM_171371.5 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 1119bp) Protein sequence SNP |
|
| Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-10-17 | |
| Organism | Caenorhabditis elegans | |
| Product | Stress-activated protein kinase jnk-1 | |
| Comment | Comment: REVIEWED REFSEQ: This record has been curated by WormBase. This record is derived from an annotated genomic sequence (NC_003282). On Sep 4, 2019 this sequence version replaced NM_171371.4. | |
1 | ATGGAACCAT CCTCTATTCA TGTTCCCGAA AACTATTATT CGGTGACAAT AGGGGAAGCG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_741434.2 |
| CDS | 228..1346 |
| Translation |
Target ORF information:
Target ORF information:
|
NM_171371.5 |
1 | ATGGAACCAT CCTCTATTCA TGTTCCCGAA AACTATTATT CGGTGACAAT AGGGGAAGCG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Genome sequence of the nematode C. elegans: a platform for investigating biology. |