| Gene Symbol | chc-1 |
| Entrez Gene ID | 176434 |
| Full Name | Probable clathrin heavy chain 1 |
| Gene Type | protein-coding |
| Organism | Caenorhabditis elegans |
ORF » Species Summary » Caenorhabditis elegans » chc-1 cDNA ORF clone
| Gene Symbol | chc-1 |
| Entrez Gene ID | 176434 |
| Full Name | Probable clathrin heavy chain 1 |
| Gene Type | protein-coding |
| Organism | Caenorhabditis elegans |
| mRNA | Protein | Name |
|---|---|---|
| NM_066859.4 | NP_499260.1 | Probable clathrin heavy chain 1 |
| NM_066859.5 | NP_499260.1 | Probable clathrin heavy chain 1 |
| Danio rerio (zebrafish) | cltca | NP_001005391.2 |
| Anopheles gambiae (African malaria mosquito) | AgaP_AGAP003021 | XP_311856.3 |
| Magnaporthe oryzae (rice blast fungus) | MGG_07768 | XP_003712981.1 |
| Homo sapiens (human) | CLTC | NP_001275582.1 |
| Bos taurus (cattle) | CLTC | NP_776448.1 |
| Mus musculus (house mouse) | Cltc | NP_001003908.1 |
| Schizosaccharomyces pombe (fission yeast) | chc1 | NP_594148.1 |
| Arabidopsis thaliana (thale cress) | AT3G08530 | NP_187466.4 |
| Kluyveromyces lactis | KLLA0F09911g | XP_455531.1 |
| Eremothecium gossypii | AGOS_AER359W | NP_985215.2 |
| Xenopus tropicalis (tropical clawed frog) | cltc | NP_001011039.1 |
| Pan troglodytes (chimpanzee) | CLTC | XP_001136053.1 |
| CLTC | XP_001108647.2 | |
| Gallus gallus (chicken) | CLTC | NP_001073586.1 |
| Danio rerio (zebrafish) | cltcb | NP_001181907.1 |
| Drosophila melanogaster (fruit fly) | Chc | NP_996451.1 |
| Saccharomyces cerevisiae (baker's yeast) | CHC1 | NP_011309.1 |
| Arabidopsis thaliana (thale cress) | AT3G11130 | NP_187724.2 |
| Canis lupus familiaris (dog) | CLTC | XP_537700.2 |
| Rattus norvegicus (Norway rat) | Cltc | NP_062172.1 |
| Caenorhabditis elegans (roundworm) | chc-1 | NP_499260.1 |
| Neurospora crassa | NCU02510 | XP_965641.1 |
Genome sequence of the nematode C. elegans: a platform for investigating biology.
Science (New York, N.Y.)282(5396)2012-8(1998 Dec)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
The clathrin heavy chain CHC-1 negatively regulates pulling forces acting on centrosomes during interphase and on spindle poles during mitosis in one-cell C. elegans embryos.
Title: Clathrin regulates centrosome positioning by promoting acto-myosin cortical tension in C. elegans embryos.
Inactivating epn-1 or chc-1 disrupts engulfment by impairing actin polymerization. CHC-1 is enriched on extending pseudopods together with EPN-1, in an EPN-1-dependent manner.
Title: Phagocytic receptor signaling regulates clathrin and epsin-mediated cytoskeletal remodeling during apoptotic cell engulfment in C. elegans.
Loss of SNX-1, RME-8, or the clathrin chaperone Hsc70/HSP-1 leads to over-accumulation of endosomal clathrin, reduced clathrin dynamics, and missorting of MIG-14 to the lysosome.
Title: Regulation of endosomal clathrin and retromer-mediated endosome to Golgi retrograde transport by the J-domain protein RME-8.
These results indicate that a high level of CHC activity is required for receptor-mediated endocytosis in nonneuronal cells but is largely dispensable for maintenance of synaptic vesicle pools.
Title: Differential requirements for clathrin in receptor-mediated endocytosis and maintenance of synaptic vesicle pools.
The following chc-1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the chc-1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
| CloneID | OCa341854 | |
| Clone ID Related Accession (Same CDS sequence) | NM_066859.4 , NM_066859.5 | |
| Accession Version | NM_066859.4 | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 5046bp) Protein sequence SNP |
|
| Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-04-08 | |
| Organism | Caenorhabditis elegans | |
| Product | Probable clathrin heavy chain 1 | |
| Comment | Comment: REVIEWED REFSEQ: This record has been curated by WormBase. This record is derived from an annotated genomic sequence (NC_003281). On Jun 26, 2012 this sequence version replaced NM_066859.3. COMPLETENESS: incomplete on both ends. | |
1 | ATGGCGCTCC CAATCAAATT TCACGAGCAC CTGCAGCTTC CGAATGCTGG AATTCGGGTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_499260.1 |
| CDS | 1..5046 |
| Translation |
Target ORF information:
Target ORF information:
|
NM_066859.4 |
1 | ATGGCGCTCC CAATCAAATT TCACGAGCAC CTGCAGCTTC CGAATGCTGG AATTCGGGTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | OCa341854 | |
| Clone ID Related Accession (Same CDS sequence) | NM_066859.4 , NM_066859.5 | |
| Accession Version | NM_066859.5 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 5046bp) Protein sequence SNP |
|
| Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-10-17 | |
| Organism | Caenorhabditis elegans | |
| Product | Probable clathrin heavy chain 1 | |
| Comment | Comment: REVIEWED REFSEQ: This record has been curated by WormBase. This record is derived from an annotated genomic sequence (NC_003281). On Sep 4, 2019 this sequence version replaced NM_066859.4. | |
1 | ATGGCGCTCC CAATCAAATT TCACGAGCAC CTGCAGCTTC CGAATGCTGG AATTCGGGTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_499260.1 |
| CDS | 52..5097 |
| Translation |
Target ORF information:
Target ORF information:
|
NM_066859.5 |
1 | ATGGCGCTCC CAATCAAATT TCACGAGCAC CTGCAGCTTC CGAATGCTGG AATTCGGGTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Genome sequence of the nematode C. elegans: a platform for investigating biology. |